Search

Your search keyword '"Kukkonen, Anna"' showing total 143 results
Start Over Author "Kukkonen, Anna"
143 results on '"Kukkonen, Anna"'

1. Human milk antibodies to global pathogens reveal geographic and interindividual variations in IgA and IgG

Author

Campo, Joseph J., Seppo, Antti E., Randall, Arlo Z., Pablo, Jozelyn, Hung, Chris, Teng, Andy, Shandling, Adam D., Truong, Johnathon, Oberai, Amit, Miller, James, Iqbal, Najeeha Talat, Yori, Pablo Penataro, Kukkonen, Anna Kaarina, Kuitunen, Mikael, Guterman, L. Beryl, Morris, Shaun K., Pell, Lisa G., Mahmud, Abdullah Al, Ramakrishan, Girija, Heinz, Eva, Kirkpatrick, Beth D., Faruque, Abu S.G., Haque, Rashidul, Looney, R. John, Kosek, Margaret N., Savilahti, Erkki, Omer, Saad B., Roth, Daniel E., Petri, William A., Jr., and Jarvinen, Kirsi M.

Subjects
Breast milk -- Composition -- Analysis, Immunoglobulin A -- Analysis, Immunoglobulin G -- Analysis, Health care industry
Abstract

BACKGROUND. The use of high-throughput technologies has enabled rapid advancement in the knowledge of host immune responses to pathogens. Our objective was to compare the repertoire, protection, and maternal factors associated with human milk antibodies to infectious pathogens in different economic and geographic locations. METHODS. Using multipathogen protein microarrays, 878 milk and 94 paired serum samples collected from 695 women in 5 high and low-to-middle income countries (Bangladesh, Finland, Peru, Pakistan, and the United States) were assessed for specific IgA and IgG antibodies to 1,607 proteins from 30 enteric, respiratory, and bloodborne pathogens. RESULTS. The antibody coverage across enteric and respiratory pathogens was highest in Bangladeshi and Pakistani cohorts and lowest in the U.S. and Finland. While some pathogens induced a dominant IgA response (Campylobacter, Klebsiella, Acinetobacter, Cryptosporidium, and pertussis), others elicited both IgA and IgG antibodies in milk and serum, possibly related to the invasiveness of the infection (Shigella, enteropathogenic E. coli 'EPEC', Streptococcus pneumoniae, Staphylococcus aureus, and Group B Streptococcus). Besides the differences between economic regions and decreases in concentrations over time, human milk IgA and IgG antibody concentrations were lower in mothers with high BMI and higher parity, respectively. In Bangladeshi infants, a higher specific IgA concentration in human milk was associated with delayed time to rotavirus infection, implying protective properties of antirotavirus antibodies, whereas a higher IgA antibody concentration was associated with greater incidence of Campylobacter infection. CONCLUSION. This comprehensive assessment of human milk antibody profiles may be used to guide the development of passive protection strategies against infant morbidity and mortality. FUNDING. Bill and Melinda Gates Foundation grant OPP1172222 (to KMJ); Bill and Melinda Gates Foundation grant OPP1066764 funded the MDIG trial (to DER); University of Rochester CTSI and Environmental Health Sciences Center funded the Rochester Lifestyle study (to RJL); and R01 AI043596 funded PROVIDE (to WAP)., Introduction In 2019, 5.3 million liveborn children died before 5 years of age worldwide, nearly half of whom died from infectious diseases, including lower respiratory infections and diarrhea (1). The [...]

Published
2024
Full Text
View/download PDF

6. A Cultural Approach to Politicization of Science: How the Forestry Coalition Challenged the Scientific Consensus in the Finnish News Media Debate on Increased Logging.

Author

Kukkonen, Anna and Malkamäki, Arttu

Subjects
*FORESTS & forestry, *FOREST policy, *LOGGING, *COALITIONS, *SOCIOCULTURAL factors, *ENVIRONMENTAL impact analysis
Abstract

Politicization of science is often described as the process of political actors overemphasizing scientific uncertainty to cast doubt on a scientific consensus. We argue that in addition to exploiting the inherent uncertainty of science, actors resort to so-called technical and national arguments to politicize science. Applying the pragmatic sociology of Boltanski and Thévenot and the method of discourse network analysis to Finnish news media debate on forest policy (2015–2020), we analyze the different modes of valuation used by the so-called forestry coalition to defend increased logging and politicize the broad scientific consensus on its harmful environmental impacts. Technical arguments appeal to the common principles of technical efficiency, productivity and expertise, while national arguments invoke shared, cultural ideas of Finnish forestry. We conclude that pragmatic sociology carries considerable potential to improve our understanding of the broader cultural factors that lay the foundation for successful politicization of science. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Early‐life environment and the risk of eczema at 2 years—Meta‐analyses of six Finnish birth cohorts

Author

Lukkarinen, Minna, primary, Kirjavainen, Pirkka V., additional, Backman, Katri, additional, Gonzales‐Inca, Carlos, additional, Hickman, Brandon, additional, Kallio, Sampo, additional, Karlsson, Hasse, additional, Karlsson, Linnea, additional, Keski‐Nisula, Leea, additional, Korhonen, Laura S., additional, Korpela, Katri, additional, Kuitunen, Mikael, additional, Kukkonen, Anna Kaarina, additional, Käyhkö, Niina, additional, Lagström, Hanna, additional, Lukkarinen, Heikki, additional, Peltola, Ville, additional, Pentti, Jaana, additional, Salonen, Anne, additional, Savilahti, Erkki, additional, Tuoresmäki, Pauli, additional, Täubel, Martin, additional, Vahtera, Jussi, additional, de Vos, Willem M., additional, Pekkanen, Juha, additional, and Karvonen, Anne M., additional

Published
2023
Full Text
View/download PDF

11. Long‐term changes in milk component immunoglobulins reflect milk oral immunotherapy outcomes in Finnish children.

Author

Kauppila, Tiina Kaisa, Hinkkanen, Victoria, Savinko, Terhi, Karisola, Piia, Kukkonen, Anna Kaarina, Paassilta, Marita, Pelkonen, Anna S., and Mäkelä, Mika J.

Subjects
GOAT milk, MILK proteins, IMMUNOGLOBULINS, MILK allergy, MILK consumption, MILK
Abstract

Background: Milk oral immunotherapy (OIT) may increase the amount of milk protein that can be ingested without triggering an allergic reaction. It is important to understand why some patients benefit from the treatment while others do not. Objective: The aim was to define the differences in the milk allergen component‐specific (casein, α‐lactalbumin, ß‐lactoglobulin) immunoglobulin (sIg [sIgE, sIgG4, and sIgA]) levels relative to the long‐term outcomes of milk OIT. Methods: In this long‐term, open‐label follow‐up study, 286 children started milk OIT between 2005 and 2015. Follow‐up data were collected at two points: the post‐buildup phase and long term (range 1–11 years, median 6 years). Comparisons of sIg levels were made among three outcome groups of self‐reported long‐term milk consumption (high‐milk dose, low‐milk dose, and avoidance). Results: A total of 168 (59%) of the 286 patients on OIT participated. Most patients (57%) were in the high‐dose group; here, 80% of these patients had a baseline casein sIgE value less than 28 kUA/L, they had the lowest casein sIgE levels at all time (p <.001), their casein sIgG4/IgE levels increased, and long‐term casein sIgA was highest compared with the low‐dose and avoidance groups (p =.02). Low‐milk dose group had the highest casein sIgG4/IgE levels in long term (p =.002). Conclusion: The baseline Ig profiles and responses to milk OIT differed depending on long‐term milk consumption. Lower casein sIgE levels were associated with better outcome. Milk casein sIgA differed in the long term among high‐milk consumers. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

13. Laukaisevat allergeenit ja anafylaksia

Author

Mäkelä, Mika, Kivistö, Juho, Kukkonen, Anna Kaarina, HUS Tulehduskeskus, Yliopiston johto, Ihotautien, allergologian ja sukupuolitautien osasto, HUS Lasten ja nuorten sairaudet, Lastenklinikka, Tampere University, and Keuhko-, iho- ja allergiasairauksien vastuualue

Subjects
Analgesics, Age Factors, Caseins, Wasp Venoms, Tropomyosin, Allergens, Ovomucin, Gliadin, Drug Hypersensitivity, +adverse effects, Bee Venoms, 3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet, Anti-Infective Agents, 3121 Sisätaudit, +etiology, Anaphylaxis, Food Hypersensitivity, Nut and Peanut Hypersensitivity
Abstract

Anafylaksian tärkeimmät laukaisijat ovat lasten osalta ruoka-aineet ja aikuisten osalta lääkkeet sekä ruoka. Suomessa 2-3 ihmistä kuolee vuosittain anafylaksiaan. He ovat lähinnä aikuisia, joiden anafylaksian laukaisevat lääkkeet tai pistiäiset. Lasten pähkinäanafylaksiat ovat lisääntyneet voimakkaasti viime vuosina. Molekyyliallergologiset diagnostiset menetelmät ja altistustutkimuksista kertynyt tieto reaktioon vaadittavasta proteiinimäärästä auttavat anafylaksiariskin arvioinnissa. Lääkeanafylaksioiden selvittämisessä tulisi huomioida valmisteiden apuaineet kuten povidoni ja makrogolit. Lääkeanafylaksiat eivät aina ole IgE-välitteisiä, ja niiden selvittely on vaikeampaa - uusien menetelmien tarve on ilmeinen. publishedVersion

Published
2021

14. The Science-Policy Interface as a Discourse Network: Finland's Climate Change Policy 2002-2015

Author

Kukkonen, Anna, Ylä-Anttila, Tuomas, Kukkonen, Anna, and Ylä-Anttila, Tuomas

Abstract

In this article, we argue that the science-policy interface can be understood as a discourse network constituted by discursive interaction between scientific organizations and other actors that both use scientific arguments in conjunction with other policy arguments. We use discourse network analysis to investigate the climate change policy process in Finland between 2002 and 2015, focusing on the role of and relationships between scientific actors and arguments in the discourse networks. Our data consist of policy actors' written testimonies on two law proposals, the ratification of the Kyoto Protocol (2002) and the enactment of the Finnish Climate Law (2015). Our results show that two competing discourse coalitions have influenced the development of climate change policy in the 2000s. In 2002, the dominant coalition was economic, prioritizing economic growth over climate change mitigation. In 2015, the climate coalition that argued for ambitious mitigation measures became dominant. The majority of scientific actors were part of the dominant economy coalition in 2002 and part of the dominant ecology coalition in 2015. The centrality of scientific arguments increased over time, and both discourse coalitions used them progressively more. These developments reflect the increasingly central position of science in Finnish climate policymaking. We contribute to the literature on the science-policy interface by operationalizing the interface as a set of connections in a discourse network and by showing how the analysis of discourse networks and their properties can help us understand the shifts in the role of science in policymaking over time.

Published
2021

16. For hazelnut allergy, component testing of Cor a 9 and Cor a 14 is relevant also in birch-endemic areas

Author

Uotila, Riikka, Röntynen, Petteri, Pelkonen, Anna S., Voutilainen, Helena, Kaarina Kukkonen, Anna, Mäkelä, Mika J., Department of Dermatology, Allergology and Venereology, HUS Inflammation Center, Helsinki University Hospital Area, and Clinicum

Subjects
birch pollen sensitization, VALUES, education, CHILDREN, PROFILES, DIAGNOSIS, PEANUT, REACTIVITY, SENSITIZATION, 3121 General medicine, internal medicine and other clinical medicine, hazelnut allergy, IGE, Cor a 1, reintroduction, whole hazelnut extract
Abstract

Non

Published
2020

18. Topic modeling for frame analysis: A study of media debates on climate change in India and USA.

Author

Ylä-Anttila, Tuukka, Eranti, Veikko, and Kukkonen, Anna

Subjects
FRAMES (Social sciences), CLIMATE change, CLIMATE research, MEDIA studies, CLIMATE change denial
Abstract

We argue that 'topics' of topic models can be used as a useful proxy for frames if (1) frames are operationalized as connections between concepts; (2) theme-specific data are used; and (3) topics are validated in terms of frame analysis. Demonstrating this, we analyse 12 climate change frames used by NGOs, governments and experts in Indian and US media, gathered by topic modeling. We contribute methodologically to topic modeling in the social sciences and frame analysis of public debates, and empirically to research on climate change media debates. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

25. Peanut oral immunotherapy increases IgG4 to Ara h 1, 2, and 6 but does not affect IgG4 to other allergens

Author

Uotila, Riikka, Kukkonen, Anna Kaarina, Greco, Dario, Pelkonen, Anna Susanna, Mäkelä, Mika Juhani, Department of Dermatology, Allergology and Venereology, Clinicum, Institute of Biotechnology, and HUS Inflammation Center

Subjects
IgG4, cross-reactivity, immuno-solid phase allergen chip, 3121 General medicine, internal medicine and other clinical medicine, parasitic diseases, peanut allergens, food and beverages, immunotherapy, ige, sensitization
Abstract

Life-threatening allergic reactions are characterized by allergen-specific IgE antibodies, whereas IgG antibodies are a default response to an antigen exposure. Subclass 4 IgG antibodies function as blocking antibodies, which may suppress IgE-mediated reactions. Peanut oral immunotherapy (OIT), as other allergen immunotherapies, induces IgG4 antibodies. We have previously shown the increase of IgG4 to peanut seed storage proteins, and the dose-dependent increase of IgG4- IgE ratios in children and adolescents receiving peanut OIT. This article is protected by copyright. All rights reserved. Non

Published
2019

26. Pistiäisallergian siedätyshoito on turvallista ja tehokasta

Author

Kauppi, Paula, Kukkonen, Anna Kaarina, Alakoskela, Juha-Matti, Pelkonen, Anna, Mäkelä, Mika, Liippo, Jussi, HUS Tulehduskeskus, Ihotautien, allergologian ja sukupuolitautien osasto, Helsingin yliopisto, and Yliopiston johto

Subjects
+diagnosis, Wasps, Insect Bites and Stings, Wasp Venoms, Immunoglobulin E, Bees, Cross Reactions, Hymenoptera, Asthma, Bee Venoms, 3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet, Treatment Outcome, Desensitization, Immunologic, +therapy, Hypersensitivity, Tryptases, +prevention & control, Anaphylaxis, Mastocytosis, Skin
Abstract

Vertaisarvioitu Ampiainen aiheuttaa Suomessa suurimman osan pistiäisen pistoihin liittyvistä anafylaksioista. Diagnostiikka on tärkeää sekä pistiäisen tunnistamiseksi että herkistymisen osoittamiseksi. Allergian osoittamiseen käytetään immunoglobuliini E -luokan vasta-aineita ampiaisen ja mehiläisen myrkylle sekä niiden allergeenikomponenteille. Kaikilta yleisreaktion saaneilta tutkitaan seerumin tryptaasin perustaso mastosytoosin poissulkemiseksi. Siedätyshoitoa suositellaan niille, jotka ovat saaneet piston yhteydessä yleistyneen allergisen reaktion.

Published
2019

27. Discourse Networks and Justifications of Climate Change Policy : News Media Debates in Canada, the United States, Finland, France, Brazil and India

Author

Kukkonen, Anna, University of Helsinki, Faculty of Social Sciences, Doctoral Programme in Social Sciences, Helsingin yliopisto, valtiotieteellinen tiedekunta, Sosiaalitieteiden tohtoriohjelma, Helsingfors universitet, statsvetenskapliga fakulteten, Doktorandprogrammet i socialvetenskap, Heikkila, Tanya, Ylä-Anttila, Tuomas, and Gronow, Antti

Subjects
Sosiologia
Abstract

This dissertation examines the role of discourse networks—defined as networks of policy actors who are related through shared political discourse—in climate change policy in Canada, the US, Finland, France, Brazil and India. The research material consists of statements from policy actors in over 2700 articles from 14 newspapers. My approach is guided by recent developments in the study of public policy and climate change policy. First, public policy studies have increasingly stressed the role of political discourse in the policy process. These approaches emphasize how political problems such as climate change are socially constructed in a specific context, and how policy actors compete over the framing of policy problems in political arenas such as the media. Second, the importance of comparative approaches that increase understanding of how different contextual factors affect climate policymaking in different countries is emphasized in the study of climate change policy. This study examines the role of discourse networks, their variation and reasons for the variation in six countries: two high-income countries where greenhouse gas (GHG) emissions per capita are high, two European Union (EU) countries where GHG emissions per capita range from high to low, and two middle-income countries where GHG emissions per capita are low. The dissertation contributes to the study of climate change policy by using the methodology of discourse network analysis and three culturally oriented theoretical approaches to policymaking. The methodology is useful, as it allows the examination of political discourse as a network. This enables analysis of the relational dimension of the policy debate which, in this case, includes competing coalitions, and central policy actors and discourses. The culturally oriented approaches are the Advocacy Coalition Framework (ACF), the world society theory and the justification theory. The ACF examines how policy actors divide into competing advocacy coalitions based on shared beliefs in limited policy subsystems. World society theory investigates how international organizations (IOs) and global norms influence national policymaking. Justification theory examines how policy actors use different moral justifications to justify their arguments in a specific political context. Together these three theoretical approaches enable the analysis of discourse networks in ways that increase comparative knowledge on climate change policy. In Article I, we show how general beliefs concerning value priorities, the role of government and validity of climate science divide policy actors into three competing coalitions—the economy, environment and science coalition—in the US climate policy debate. Specific beliefs concerning policy instruments such as cap and trade do not divide policy actors into coalitions. Article II demonstrates how the role of IOs varies between high-income and middle-income countries. IOs have a stronger role in the policy debates in middle-income countries (Brazil and India) where GHG emissions per capita are low. In the high-income countries (Canada and the US) where GHG emissions per capita are high, IOs have a weaker role and the global norms face opposition from coalitions of national policy actors. Article III examines the Arctic climate change policy debate in Finland and Canada which represent different institutional and political-economic contexts. In both countries, market and ecological justifications are common and often in conflict. In corporatist Finland, where the fossil fuel industry is not as influential, policy actors use ecological justifications and civic justifications that value international cooperation more. In pluralist Canada, where the fossil fuel industry is influential, policy actors use civic justifications that underline national sovereignty and industrial justifications that emphasize climate science more. Article IV shows how the use of justifications varies across two different political cultures. Market justifications, that emphasize monetary value, are more common in the US climate change policy debate. Civic justifications, that underline the importance of state regulation and justice, are more prevalent in the French debate. As a whole, this dissertation argues that discourse networks play an important role in national climate change policy. Future studies should further analyze what types of climate policy instruments can find support among competing coalitions in different national contexts. This would generate valuable theoretical and practical knowledge on climate change policy in 21st century capitalist societies. Tämä väitöskirja tarkastelee diskurssiverkostojen roolia—määriteltynä poliittisten toimijoiden verkostoina, joissa poliittiset toimijat ovat yhteydessä jaettujen poliittisten diskurssien kautta—Kanadan, Yhdysvaltojen, Suomen, Ranskan, Brasilian ja Intian ilmastopolitiikassa. Tutkimusaineisto koostuu poliittisten toimijoiden lausunnoista yli 2700 artikkelista 14 sanomalehdessä. Näkökulmaani ohjaavat viimeaikaiset kehityskulut politiikan ja ilmastopolitiikan tutkimuksessa. Ensiksi, politiikan tutkimuksessa on alettu lisääntyvästi korostaa poliittisen diskurssin roolia poliittisessa prosessissa. Nämä näkökulmat korostavat, että poliittiset ongelmat kuten ilmastonmuutos ovat sosiaalisesti rakentuneita tietyssä kontekstissa, ja miten poliittiset toimijat kilpailevat poliittisten ongelmien kehystämisestä poliittisilla areenoilla kuten mediassa. Toiseksi, ilmastopolitiikan tutkimuksessa on alettu korostaa vertailevia lähestymistapoja, jotka parantavat ymmärrystä eri kontekstuaalisten tekijöiden vaikutuksesta ilmastopolitiikkaan eri maissa. Tämä tutkimus tarkastelee diskurssiverkostojen roolia, niiden vaihtelua ja syitä vaihtelulle kuudessa maassa: kahdessa korkean tulotason maassa, joissa kasvihuonekaasupäästöt asukasta kohden ovat korkeat (Kanada ja Yhdysvallat); kahdessa Euroopan Unionin (EU) maassa, joissa kasvihuonekaasupäästöt asukasta kohden vaihtelevat korkeasta matalaan (Suomi ja Ranska); ja kahdessa keskitulotason maassa, joissa kasvihuonekaasupäästöt asukasta kohden ovat matalat (Brasilia ja Intia). Tämä väitöskirja edistää ilmastopolitiikan tutkimusta käyttämällä diskurssiverkostoanalyysin menetelmää ja kolmea kulttuurisesti suuntautunutta teoreettista lähestymistapaa politiikantekoon. Menetelmä on hyödyllinen, koska sen avulla voi tarkastella poliittista diskurssia verkostona. Tämä mahdollistaa poliittisen keskustelun relationaalisen ulottuvuuden analyysin, joka, tässä tapauksessa, sisältää kilpailevat koalitiot, ja keskeiset poliittiset toimijat ja diskurssit. Kulttuurisesti suuntautuneet näkökulmat ovat the Advocacy Coalition Framework (ACF), maailmanyhteiskunnan teoria ja oikeuttamisteoria. ACF tutkii sitä, miten poliittiset toimijat jakaantuvat kilpaileviin koalitioihin yhteisten uskomusten perusteella rajatuissa politiikan alajärjestelmissä. Maailmanyhteiskunnan teoria tarkastelee sitä, miten kansainväliset organisaatiot ja globaalit normit vaikuttavat kansalliseen politiikkaan. Oikeuttamisteoria tutkii sitä, miten poliittiset toimijat käyttävät erilaisia moraalisia oikeutuksia perustellessaan argumenttejaan tietyssä poliittisessa kontekstissa. Yhdessä nämä kolme teoreettista lähestymistapaa mahdollistavat diskurssiverkostojen analyysin tavoilla, jotka lisäävät vertailevaa tietoa ilmastopolitiikasta. Artikkelissa I näytämme, miten yleiset uskomukset arvoprioriteeteista, valtion roolista ja ilmastotieteen oikeellisuudesta jakavat poliittiset toimijat kolmeen kilpailevaan koalitioon—talous-, ympäristö-, ja tiedekoalitioon—Yhdysvaltojen ilmastopoliittisessa keskustelussa. Spesifit uskomukset politiikan välineistä kuten päästökaupasta eivät jaa poliittisia toimijoita koalitioihin. Artikkeli II osoittaa, miten kansainvälisten organisaatioiden rooli vaihtelee korkean tulotason ja keskitulotason maissa. Keskitulotason maissa, joissa kasvihuonekaasupäästöt asukasta kohden ovat alhaiset, kansainvälisillä organisaatioilla on vahvempi rooli. Korkean tulotason maissa, joissa kasvihuonekaasupäästöt asukasta kohden ovat korkeat, kansainvälisillä organisaatioilla on heikompi rooli ja globaalit normit kohtaavat vastustusta kansallisista toimijoista koostuvista koalitioista. Artikkeli III tarkastelee Arktista ilmastopolitiikkaa koskevaa keskustelua Suomessa ja Kanadassa, jotka edustavat eri institutionaalisia ja poliittis-taloudellisia konteksteja. Molemmissa maissa markkinaoikeutukset ja ekologiset oikeutukset ovat yleisiä ja usein ristiriidassa. Korporatistisessa Suomessa, jossa fossiiliteollisuus ei ole yhtä vaikutusvaltainen, poliittiset toimijat käyttävät ekologisia oikeutuksia ja kansainvälistä yhteistyötä arvostavia kansalaisuuden maailman oikeutuksia enemmän. Pluralistisessa Kanadassa, jossa fossiiliteollisuus on vaikutusvaltainen, poliittiset toimijat käyttävät kansallista suvereniteettia arvostavia kansalaisuuden maailman oikeutuksia ja ilmastotiedettä arvostavia teollisuuden maailman oikeutuksia enemmän. Artikkeli IV näyttää, miten oikeutusten käyttö vaihtelee kahden eri poliittisen kulttuurin välillä. Markkinaoikeutukset, jotka korostavat rahallista arvoa, ovat yleisempiä Yhdysvaltojen ilmastopoliittisessa keskustelussa. Kansalaisuuden maailmaan pohjautuvat oikeutukset, jotka alleviivaavat valtion sääntelyn ja oikeudenmukaisuuden tärkeyttä, ovat vallitsevia Ranskan keskustelussa. Kokonaisuudessaan tämä väitöskirja esittää, että diskurssiverkostoilla on tärkeä rooli kansallisessa ilmastopolitiikassa. Jatkotutkimuksissa tulisi analysoida sitä, millaiset ilmastopolitiikan välineet voivat saada kannatusta kilpailevien koalitioiden välillä eri kansallisissa konteksteissa. Tämä synnyttäisi arvokasta teoreettista ja käytännöllistä tietoa ilmastopolitiikasta 2000-luvun kapitalistisissa yhteiskunnissa.

Published
2018

28. Topic Modeling as a Method for Frame Analysis: Data Mining the Climate Change Debate in India and the USA

Author

Ylä-Anttila, Tuukka, Eranti, Veikko, and Kukkonen, Anna

Subjects
SocArXiv|Social and Behavioral Sciences|Sociology|Methodology, Methodology, bepress|Social and Behavioral Sciences|Sociology|Civic and Community Engagement, Political Sociology, Social and Behavioral Sciences, SocArXiv|Social and Behavioral Sciences|Sociology|Environmental Sociology, FOS: Sociology, bepress|Social and Behavioral Sciences|Sociology, SocArXiv|Social and Behavioral Sciences|Sociology, bepress|Social and Behavioral Sciences|Sociology|Quantitative, Qualitative, Comparative, and Historical Methodologies, Sociology, Environmental Sociology, bepress|Social and Behavioral Sciences, bepress|Social and Behavioral Sciences|Sociology|Place and Environment, SocArXiv|Social and Behavioral Sciences, SocArXiv|Social and Behavioral Sciences|Sociology|Political Sociology
Abstract

This article proposes an operationalization of topic modeling as a data mining method for studying framing in public debates. We argue that 'topics' can be interpreted as frames, if 1) frames are operationalized as connections between concepts, 2) subject-specific data is selected, and 3) topics are adequately validated as frames, for which we suggest a practical procedure. As an empirical example, we study the global climate change debate in the media, by comparing frames used by NGO's, governments and experts in India and the USA. Our model identifies 12 framings of climate change, used in varied proportions by the different actors in the two countries. Topic modeling frames enables the usage of larger datasets and facilitates discovery of previously unnoticed framing patterns. It does not replace qualitative interpretation, but rather complements it by enabling a degree of automated classification before the interpretive stage.

Published
2018
Full Text
View/download PDF

34. Actors and justifications in media debates on Arctic climate change in Finland and Canada: A network approach.

Author

Kukkonen, Anna, Stoddart, Mark CJ, and Ylä-Anttila, Tuomas

Subjects
*CLIMATE change, *MASS media, *SUSTAINABILITY, *SOVEREIGNTY
Abstract

In this paper, we examine the centrality of policy actors and moral justifications in media debates on Arctic climate change in Finland and Canada from 2011–2015. We take a network approach on the media debates by analysing relations between the actors and justifications, using discourse network analysis on a dataset of 745 statements from four newspapers. We find that in both countries, governments and universities are the most central actors, whereas business actors are the least central. Justifications that value environmental sustainability and scientific knowledge are most central and used across actor types. However, ecological justifications are sometimes in conflict with market justifications. Government actors emphasize new economic possibilities in the Arctic whereas environmental organizations demand greater protection of the vulnerable Arctic. Ecological justifications and justifications that value international cooperation are more central in the Finnish debate, whereas justifications valuing sustainability and science, as well as those valuing national sovereignty, are more central in the Canadian debate. We conclude that in addition to the centrality of specific policy actors in media debates, the use of different types of moral justifications also reflects political power in the media sphere. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

35. Advocacy coalitions, beliefs and climate change policy in the United States

Author

Kukkonen, Anna Kristiina, Ylä-Anttila, Matti Tuomas, Broadbent, Jeffrey, Sociology, and Department of Social Research (2010-2017)

Subjects
517 Political science
Abstract

The Advocacy Coalition Framework (ACF) asserts that disagreement over policy core beliefs divides organizations into competing coalitions. We apply Discourse Network Analysis to 1,410 statements in the Wall Street Journal, New York Times and USA Today to investigate what kinds of beliefs contribute to coalition formation in the climate change policy debate in the news media in the United States. We find that the beliefs concerning the reality of anthropogenic climate change, the importance of ecology over economy and desirability of governmental regulation divide organizations into three advocacy coalitions: the economy, ecology and science coalitions. Policy preferences such as cap and trade do not; they find support across coalition lines. Based on these findings, we suggest that ACF theory could be clarified to better account for how beliefs concerning policy instruments contribute to coalition formation. In some policy domains, policy instruments are where opposing coalitions find agreement. In others, they are more divisive.

Published
2017

36. Kenelle siedätyshoitoa?

Author

Kauppi, Paula, Kukkonen, Anna Kaarina, Ihotautien, allergologian ja sukupuolitautien osasto, Clinicum, and HUS Tulehduskeskus

Subjects
Mites, 3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet, Dander, Desensitization, Immunologic, Hypersensitivity, Pollen, Rhinitis, Allergic, Seasonal, +prevention & control, Hymenoptera, Food Hypersensitivity
Abstract

Jos allergiset nuha-, silmä- ja astmaoireet ovat vaikeita vuodesta toiseen tavanomaisesta lääkityksestä ¬huolimatta, IgE-välitteiseen allergiaan voidaan antaa siedätyshoitoa. Yleisimmät hoidon aiheet ovat koivu- ja timoteiallergia. Myös eläimille voidaan siedättää, jos tavanomaisen allergialääkityksen teho on riittämätön eikä kontaktia eläimiin pysty kohtuudella välttämään tai jos jo epäsuora kontakti aiheuttaa oireita. Pistiäisallergia on harvinainen, mutta erityinen siedätyshoidon aihe, sillä ampiaisen tai mehiläisen piston aiheuttama anafylaktinen reaktio voi olla hengenvaarallinen.

Published
2017

43. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

Author

Pouessel, Guillaume, Claverie, Claire, Labreuche, Julien, Renaudin, Jean-Marie, Dorkenoo, Aimée, Eb, Mireille, Moneret-Vautrin, Anne, Deschildre, Antoine, Leteurtre, Stephane, Grabenhenrich, Linus, Worm, Margitta, Dölle, Sabine, Scherer, Kathrin, Hutteger, Isidor, Christensen, Morten, Bindslev-Jensen, Carsten, Mortz, Charlotte, Eller, Esben, Kjaer, Henrik F, Carneiro-Leão, Leonor, Badas, Jenny, Coimbra, Alice, Levy, Dikla P, Ben-Shoshan, Moshe, Rimon, Ayelet, Benor, Shira, Arends, Nicolette J T, Edelbroek, Nikki, de Groot, Hans, Emons, Joyce A M, Brand, H. K A, Verhoeven, Dirk, van Veen, Leonieke N, de Jong, Nicolette W, Noh, Geunwoong, Jang, Eun H, Pascal, Mariona, Dominguez, Olga, Piquer, Mònica, Alvaro, Montserrat, Jimenez-Feijoo, Rosa, Lozano, Jaime, Machinena, Adriana, del Mar Folqué, Maria, Giner, Maria T, Plaza, Ana M, Turner, Paul, Patel, Nandinee, Vazquez-Ortiz, Marta, Lindsley, Sarah, Walker, Lucy, Rosenberg, Simon, Mari, Adriano, Alessandri, Claudia, Giangrieco, Ivana, Tuppo, Lisa, Rafaiani, Chiara, Mitterer, Georg, Ciancamerla, Michela, Ferrara, Rosetta, Bernardi, Maria L, Zennaro, Danila, Tamburrini, Maurizio, Ciardiello, Maria A, Harwanegg, Christian, Fernandez, Antonio, Selb, Regina, Egenmann, Philippe, Epstein, Michelle, Hoffmann-Sommergruber, Karin, Koning, Frits, Lovik, Martinus, Clare Mills, E. N, Moreno, Javier, van Loveren, Henk, Wal, Jean-Michel, Diesner, Susanne, Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera E, Starkl, Philipp, Endesfelder, David, Eiwegger, Thomas, Szepfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, Untersmayr, Eva, Wille, Soren, Meyer, Peter, Klingebiel, Caroline, Lidholm, Jonas, Ehrenberg, Angelica, Östling, Jonas, Cleach, Isabelle, Mège, Jean-Louis, Vitte, Joana, Aina, Roberta, Dubiela, Pawel, Pfeifer, Sabine, Bublin, Merima, Radauer, Christian, Humeniuk, Piotr, Kabasser, Stefan, Asero, Riccardo, Bogas, Gador, Gomez, Francisca, Campo, Paloma, Salas, Maria, Doña, Inmaculada, Barrionuevo, Esther, Guerrero, Maria A, Mayorga, Cristobalina, Prieto, Ana, Barber, Domingo, Torres, Maria J, Jamin, Annette, Wangorsch, Andrea, Ballmer, Barbara, Vieths, Stefan, Scheurer, Stephan, Apostolovic, Danijela, Mihailovic, Jelena, Krstic, Maja, Starkhammar, Maria, Velickovic, Tanja C, Hamsten, Carl, van Hage, Marianne, van Erp, Francine C, Knol, Edward F, Kansen, Hannah M, Pontoppidan, Bo, Meijer, Yolanda, van der Ent, Cornelis K, Knulst, André C, Sayers, Rebekah, Brown, Helen, Custovic, Adnan, Simpson, Angela, Mills, Claire, Schulz, Juliane, Akkerdaas, Jaap, Totis, Muriel, Capt, Annabelle, Herouet-Guicheney, Corinne, van Ree, Ronald, Banerjee, Tushar, Banerjee, Antima, Claude, Mathilde, Bouchaud, Grégory, Lupi, Roberta, Castan, Laure, Tranquet, Olivier, Denery-Papini, Sandra, Bodinier, Marie, Brossard, Chantal, De Poi, Rosella, Gritti, Elisa, De Dominicis, Emiliano, Popping, Bert, de Laureto, Patrizia P, Palosuo, Kati, Kukkonen, Anna K, Pelkonen, Anna, Mäkelä, Mika, Lee, Nanju A, Rost, Johanna, Muralidharan, Sridevi, Campbell, Dianne, Mehr, Sam, Nock, Catherine, Baumert, Joseph, Taylor, Steve, Mastrorilli, Carla, Tripodi, Salvatore, Caffarelli, Carlo, Perna, Serena, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Dondi, Arianna, Bianchi, Annamaria, Dascola, Carlotta P, Ricci, Giampaolo, Cipriani, Francesca, Maiello, Nunzia, del Giudice, Michele M, Frediani, Tullio, Frediani, Simone, Macrì, Francesco, Pistoletti, Chiara, Iacono, Iride D, Patria, Maria F, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Olcese, Roberta, Moretti, Matteo, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Verga, Maria C, Calvani, Mauro, Giordani, Paolo, Matricardi, Paolo M, Ontiveros, Noe, Cabrera-Chavez, Francisco, Galand, Julie, Beaudouin, Etienne, Pineau, Florence, Sakai, Shinobu, Matsunaga, Kayoko, Teshima, Reiko, Larré, Colette, Denery, Sandra, Tschirner, Sebastian, Trendelenburg, Valérie, Schulz, Gabriele, Niggemann, Bodo, Beyer, Kirsten, Bouferkas, Youcef, Belabbas, Younes, Saidi, Djamel, Kheroua, Omar, Mecherfi, Kamel E E, Guendouz, Malika, Haddi, Abir, Kaddouri, Hanane, Amaral, Luis, Pereira, Ana, Rodrigues, Susana, Datema, Mareen, Jongejan, Laurian, Clausen, Michael, Knulst, Andre, Papadopoulos, Nikolaos, Kowalski, Marek, de Blay, Frédéric, Zwinderman, Aeilko, Hoffman-Sommergruber, Karin, Ballmer-Weber, Barbara, Fernandez-Rivas, Montserrat, Deng, Shan, Yin, Jia, Eisenmann, Charlotte, Nassiri, Maria, Reinert, Rabea, van der Valk, Johanna P M, van Wijk, Roy G, Vergouwe, Yvonne, Steyerberg, Ewout W, Reitsma, Marit, Wichers, Harry J, Savelkoul, Huub F J, Vlieg-Boerstra, Berber, Dubois, Anthony E J, Carolino, Fabrícia, Rodolfo, Ana, Cernadas, Josefina, Roa-Medellín, Dasha, Rodriguez-Fernandez, Ana, Navarro, Joaquín, Albendiz, Vicente, Baeza, María L, Intente-Herrero, Sonsoles, Mikkelsen, Andrea, Mehlig, Kirsten, Lissner, Lauren, Verrill, Linda, Luccioli, Stefano, van Bilsen, Jolanda, Kuper, Frieke, Wolterbeek, André, Rankouhi, Tanja R, Verschuren, Lars, Cnossen, Hilde, Jeurink, Prescilla, Garssen, Johan, Knippels, Léon, Garthoff, Jossie, Houben, Geert, Leeman, Winfried, Eleonore Pettersson, M., Schins, Afke M M, Koppelman, Gerard H, Kollen, Boudewjin J, Zubchenko, Svitlana, Kuntz, Sarah, Mérida, Pablo, Álvaro, Montserrat, Piquer, Monica, Riggioni, Carmen, Castellanos, Juan H, Jimenez, Rosa, Cap, Melanie, Drumez, Elodie, Lejeune, Stéphanie, Thumerelle, Caroline, Mordacq, Clémence, Nève, Véronique, Ricò, Sonia, Varini, Margherita, Nocerino, Rita, Cosenza, Linda, Amoroso, Antonio, Di Costanzo, Margherita, Di Scala, Carmen, Bedogni, Giorgio, Canani, Roberto B, Turner, Paul J, Poza-Guedes, Paloma, González-Pérez, Ruperto, Sánchez-Machín, Inmaculada, Matheu-Delgado, Victor, Wambre, Erik, Ballegaard, Anne-Sofie, Madsen, Charlotte, Gregersen, Juliane, Bøgh, Katrine L, Aubert, Philippe, Neunlist, Michel, Magnan, Antoine, Lozano-Ojalvo, Daniel, Pablos-Tanarro, Alba, Pérez-Rodríguez, Leticia, Molina, Elena, López-Fandiño, Rosina, Rekima, Akila, Macchiaverni, Patricia, Turfkruyer, Mathilde, Holvoet, Sebastien, Dupuis, Lénaïck, Baiz, Nour, Annesi-Maesano, Isabella, Mercenier, Annick, Nutten, Sophie, Verhasselt, Valérie, Mrakovcic-Sutic, Ines, Banac, Srdan, Sutic, Ivana, Baricev-Novakovic, Zdenka, Sutic, Ingrid, Pavisic, Valentino, Muñoz-Cano, Rosa, Jiménez-Rodríguez, Teodoríkez, Corbacho, Daniel, Roca-Ferrer, Jordi, Bartra, Joan, Bulog, Aleksandar, Micovic, Vladimir, Markiewicz, Lidia, Szymkiewicz, Agata, Szyc, Anna, Wróblewska, Barbara, Harvey, Bryan M, Harthoorn, Lucien F, Wesley Burks, A., Rentzos, Georgios, Björk, Anna-Lena B, Bengtsson, Ulf, Barber, Colin, Kalicinsky, Chrystyna, Breynaert, Christine, Coorevits, Lieve, Jansen, Cornelia, Van Hoeyveld, Erna, Verbeke, Kristin, Kochuyt, Anne-Marie, Schrijvers, Rik, Deleanu, Diana, Muntean, Adriana, Konstantakopoulou, Maria, Pasioti, Maria, Papadopoulou, Anastasia, Iliopoulou, Anna, Mikos, Nikolaos, Kompoti, Evangelia, de Castro, Eunice D, Bartalomé, Borja, Ue, Kok L, Griffiths, Elizabeth, Till, Stephen, Grimshaw, Kate, Roberts, Graham, Selby, Anna, Butiene, Indre, Larco, Jose I, Dubakiene, Ruta, Fiandor, Ana, Fiocchi, Alessandro, Papadopoulos, Nikos, Sigurdardottir, Sigurveig, Sprikkelman, Aline, Schoemaker, Anne-Fleur, Xepapadaki, Paraskevi, Keil, Thomas, Cojocariu, Zizi, Barbado, Beatriz S, Iancu, Vasti, Arroabarren, Esozia, Esarte, Marta G, Arteaga, Miren, Andrade, Mayra C, Borges, Denise, Kalil, Jorge, Bianchi, Pedro G, Agondi, Rosana C, Gupta, Rinkesh K, Sharma, Akanksha, Gupta, Kriti, Das, Mukul, Dwivedi, Premendra, Karseladze, Rusudan, Jorjoliani, Liana, Saginadze, Lali, Tskhakaia, Mariam, Basello, Katia, Piuri, Gabriele, Speciani, Attilio F, Speciani, Michela C, Camerotto, Carla, Zinno, Francesco, Pakholchuk, Olga, Nedelska, Svitlana, Pattini, Stefano, Costantino, Maria T, Peveri, Silvia, Villalta, Danilo, Savi, Eleonora, Costanzi, Andrea, Revyakina, Vera A, Kiseleva, Marina A, Kuvshinova, Elena D, Larkova, Inna A, Shekhetov, Anton A, Silva, Diana, Moreira, André, Plácido, José, van der Kleij, Hanneke, van Twuijver, Esther, Sutorius, Robbert, de Kam, Pieter-Jan, van Odijk, Jenny, Lindqvist, Helen, Lustig, Elin, Jácome, Amyra A A, Aguilar, Karla L B, Domínguez, Miguel G, Hernández, David A M, Caruso, Cristiano, Casale, Cono, Rapaccini, Gian L, Romano, Antonino, De Vitis, Italo, Cocco, Renata R, Aranda, Carolina, Mallozi, Marcia C, Motta, Jackeline F, Moraes, Lilian, Pastorino, Antonio, Rosario, Nelson, Goudouris, Ekaterini, Porto, Arnaldo, Wandalsen, Neusa F, Sarinho, Emanuel, Sano, Flavio, Solé, Dirceu, Pitsios, Constantinos, Petrodimopoulou, Maria, Papadopoulou, Ekaterini, Passioti, Maria, Kontogianni, Meropi, Adamia, Nino, Khaleva, Ekaterina, del Prado, Ana P, Du Toit, George, Krzych, Edyta, Samolinska-Zawisza, Urszula, Furmanczyk, Konrad, Tomaszewska, Aneta, Raciborski, Filip, Lipiec, Agnieszka, Samel-Kowalik, Piotr, Walkiewicz, Artur, Borowicz, Jacek, Samolinski, Boleslaw, Nano, Aimee L, Recto, Marysia, Somoza, Maria L, López, Natalia B, Alzate, Diana P, Ruano, Francisco J, Garcimartín, Maria I, Haroun, Elisa, de la Torre, Maria V, Rojas, Antonia, Onieva, Montserrat L, Canto, Gabriela, Rodrigues, Alexandra, Forno, Andreia, Cabral, António J, Gonçalves, Rute, Vorozhko, Ilya, Sentsova, Tatyana, Chernyak, Olga, Denisova, Svetlana, Ilènko, Lidia, Muhortnich, Valery, Zimmermann, Caroline, Rohrbach, Alexander, Bakhsh, Faisal R, Boudewijn, Kollen, Oomkes-Pilon, Anne-Marie, Van Ginkle, Dorien, Šilar, Mira, Jeverica, Anja, Vesel, Tina, Avčin, Tadej, Korošec, Peter, van der Valk, Johanna, Berends, Irene, Arends, Nicolette, van Maaren, Maurits, Wichers, Harry, Emons, Joyce, Dubois, Anthony, de Jong, Nicolette, Matsyura, Oksana, Besh, Lesya, Huang, Chung-Hsiung, Jan, Tong-Rong, Stiefel, Gary, Tratt, Jean, Kirk, Kerrie, Carolino, Fabricia, Arasi, Stefania, Caminiti, Lucia, Crisafulli, Giuseppe, Fiamingo, Chiara, Fresta, Jlenia, Pajno, Giovanni, Remington, Ben, Kruizinga, Astrid, Marty Blom, W., Westerhout, Joost, Bijlsma, Sabina, Baumert, Joe, Blankestijn, Mark, Otten, Henny, Klemans, Rob, Michelsen-Huisman, Anouska D, van Os-Medendorp, Harmieke, Kruizinga, Astrid G, Versluis, Astrid, van Duijn, Gert, de Zeeuw-Brouwer, H. M, Castenmiller, Jacqueline J M, Noteborn, Hub P J M, Houben, Geert F, Bravin, Kristian, Luyt, David, Javed, Bushra, Couch, Phil, Munro, Christopher, Padfield, Phil, Sperrin, Matt, Byrne, Aideen, Oosthuizen, Lizalet, Kelleher, Carina, Ward, Fiona, Brosnan, Niamh, King, Graham, Corbet, Eva, Guzmán, Josué A H, García, Montserrat B, Asensio, Oscar, Navarrete, Laura V, Larramona, Helena, Miró, Xavier D, Pyrz, Katarzyna, Austin, Moira, Boloh, Yanne, Couch, Philip, Galloway, Deirdre, Hernandez, Pilar, Hourihane, Jonathan O, Kenna, Fiona, Majkowska-Wojciechowska, Barbara, Regent, Lynne, Themisb, Marina, Schnadt, Sabine, Semic-Jusufagic, Aida, Galvin, Audrey D, Kauppila, Tiina, Kuitunen, Mikael, Kitsioulis, Nikolaos A, Douladiris, Nikolaos, Kostoudi, Sofia, Manolaraki, Ioanna, Mitsias, Dimitris, Manousakis, Emmanouil, Papadopoulos, Nikolaos G, Knibb, Rebecca, Hammond, Jennifer, Cooke, Richard, Yrjänä, Jaakko, Hanni, Anna-Maija, Vähäsarja, Päivi, Mustonen, Oona, Dunder, Teija, Kulmala, Petri, Lasa, Eva, D’Amelio, Carmen, Martínez, Sara, Joral, Alejandro, Gastaminza, Gabriel, Goikoetxea, Maria J, Candy, David C A, Van Ampting, Marleen T J, Oude Nijhuis, Manon M, Butt, Assad M, Peroni, Diego G, Fox, Adam T, Knol, Jan, Michaelis, Louise J, Padua, Ines, Padrao, Patricia, Moreira, Pedro, Barros, Renata, Sharif, Hanan, Ahmed, Manzoor, Gomaa, Nehad, Mens, Joris, Smit, Koen, Timmermans, Frans, Poredoš, Tomaž, Jeverica, Anja K, Sedmak, Marjeta, Benedik, Evgen, Accetto, Meta, Zupančič, Mirjana, Yonamine, Glauce, Soldateli, Gustavo, Aquilante, Bruna, Pastorino, Antonio C, de Moraes Beck, Cleonir L, Gushken, Andrea K, de Barros Dorna, Mayra, dos Santos, Cristiane N, Castro, Ana P M, Al-Qahtani, Abdulhadi, Arnaout, Rand, Khaliq, Agha R, Amin, Rashid, Sheikh, Farrukh, Alvarez, Jorge, Anda, Marta, Palacios, Miriam, De Prada, Montserrat, Ponce, Carmen, Balbino, Bianca, Sibilano, Riccardo, Marichal, Thomas, Gaudenzio, Nicolas, Karasuyama, Hajime, Bruhns, Pierre, Tsai, Mindy, Reber, Laurent L, Galli, Stephen J, Ferreira, Ana R, Cernadas, Josefina R, del Campo García, Aida, Fernández, Sara P, Carrera, Nerea S, Sánchez-Cruz, Fernando B, Lorenzo, José R F, Claus, Stephanie, Pföhler, Claudia, Ruëff, Franziska, Treudler, Regina, Jaume, Mercedes E, Madroñero, Agustin, Perez, Maria T G, Julia, Juan C, Plovdiv, Charlotte H, Gethings, Lee, Langridge, Jim, Adel-Patient, Karine, Bernard, Hervé, Barcievic-Jones, Ivona, Sokolova, Raditsa, Yankova, Rumyana, Ivanovska, Mariya, Murdjeva, Marianna, Popova, Tatyana, Dermendzhiev, Svetlan, Karjalainen, Martin, Lehnigk, Ulrike, Brown, Duncan, Locklear, Julie C, Locklear, Julie, Maris, Ioana, Hourihane, Jonathan, Ornelas, Cristina, Caiado, Joana, Ferreira, Manuel B, Pereira-Barbosa, Manuel, Puente, Yolanda, Daza, Juan C, Monteseirin, Francisco J, Ukleja-Sokolowska, Natalia, Gawronska-Ukleja, Ewa, Zbikowska-Gotz, Magdalena, Bartuzi, Zbigniew, Sokolowski, Lukasz, Adams, Aine, Mahon, Bernard, English, Karen, Gourdon-Dubois, Nelly, Sellam, Laetitia, Pereira, Bruno, Michaud, Elodie, Messaoudi, Khaled, Evrard, Bertrand, Fauquert, Jean-Luc, Palomares, Francisca, Gomez, Gador, Rodriguez, Maria J, Galindo, Luisa, Molina, Ana, Paparo, Lorella, Mennini, Maurizio, Aitoro, Rosita, Wawrzeńczyk, Adam, Przybyszewski, Michał, Wawrzeńczyk, Anna, Sarıcoban, Hulya E, Ugras, Meltem, Yalvac, Zerrin, Flokstra-de Blok, Bertine M J, van der Velde, J. L, Vereda, Andrea, Ippolito, Clara, Traversa, Amaranta, Adriano, Daniela, Bianchi, Daniela M, Gallina, Silvia, Decastelli, Lucia, Makatsori, Melina, Miles, Anne, Devetak, Sonja P, Devetak, Iztok, Tabet, Soraya A, Trandbohus, Jeanette F, Winther, Pernille, Malling, Hans-Jørgen, Hansen, Kirsten S, Garvey, Lene H, Wang, Chia-Chi, Cheng, Yin-Hua, Tung, Chun-Wei, Dietrich, Mariola, Marenholz, Ingo, Kalb, Birgit, Grosche, Sarah, Blümchen, Katharina, Schlags, Rupert, Price, Mareike, Rietz, Sylke, Esparza-Gordillo, Jorge, Lau, Susanne, Lee, Young-Ae, Almontasheri, Ali, Bahkali, Mohammad A, Elshorbagi, Sahar, Alfhaid, Abdullah, Altamimi, Mashary, Madbouly, Eman, Al-Dhekri, Hassan, Arnaout, Rand K, Basagaña, Maria, Miquel, Sira, Bartolomé, Borja, Brix, Bettina, Rohwer, Stefanie, Brandhoff, Sandra, Berger, Alena, Suer, Waltraud, Weimann, Alf, Bueno, Cristina, Martín-Pedraza, Laura, Abián, Sara, Segundo-Acosta, Pablo S, López-Rodríguez, Juan C, Barderas, Rodrigo, Batanero, Eva, Cuesta-Herranz, Javier, Villalba, María T, Correia, Magna, Benito-Garcia, Filipe, Arêde, Cristina, Piedade, Susana, Morais-Almeida, Mário, Hindley, James, Yarham, Ross, Kuklinska-Pijanka, Anna, Gillick, David, Patient, Karine, Chapman, Martin D, Miranda, Ana, Matos, Eugénia, Sokolova, Anna, Rao, Huan, Baricevic-Jones, Ivona, Smith, Frances, Xue, Wentong, Magnusdottir, Helga, Vidarsdottir, Anna G, Lund, Sigrun, Jensen, Anders B, Ludviksson, Bjorn R, Simon, Reyna, Elfont, Robert, Bennett, Sean, Voyksner, Robert, de Lurdes Torre, Maria, Yürek, Songül, Faber, Margaretha A, Bastiaensen, Annick, Mangodt, Evelyne, van Gasse, Athina, Decuyper, Ine, Sabato, Vito, Hagendorens, Margo M, Bridts, Chris H, De Clerck, Luc S, Ebo, Didier, Schwarz, Susanne, Ziegert, Mandy, Albroscheit, Saskia, Schwager, Christian, Kull, Skadi, Behrends, Jochen, Röckendorf, Niels, Schocker, Frauke, Frey, Andreas, Homann, Arne, Becker, Wolf-Meinhard, Jappe, Uta, Zaabat, Nesrine, Osscini, Sylvia, Agabriel, Chantal, Sterling, Benoît, Carsin, Ania, Liabeuf, Valérie, Maćków, Monica, Zbróg, Alina, Bronkowska, Monica, Courtois, Justine, Gadisseur, Romy, Bertholet, Catherine, Lukas, Pierre, Cavalier, Etienne, Delahaut, Philippe, Quinting, Birgit, Gertmo, Margareta B, Hasseus, Ewa T, Barzylovych, Vladyslava, Oliveira, Júlio, Ensina, Luis F, Aranda, Carolina S, Dopazo, Leire, Lopez, Rebeca, Perez, Raquel, Santos-Diez, Laura, Bilbao, Agurtzane, Garcia, Juan M, Núñez, Ignacio G, Mármol, María Á A, Villarejo, María J B, Martos, José A B, Vergara, Marina S, García, José M I, Michalska, Agata, Sergiejko, Grzegorz, Zacniewski, Robert, Ghiordanescu, Ileana-Maria, Deaconu, Cristina, Popescu, Mihaela, Bumbacea, Roxana S, Ibranji, Alkerta, Nikolla, Elida, Loloci, Gjustina, Juel-Berg, Nanna, Larsen, Lau F, Poulsen, Lars K, Marcelino, João, Prata, Ricardo, Costa, Ana C, Duarte, Fátima, Neto, Marta, Santos, Jennifer, Pestana, Luís C, Sampaio, Daniel, Minale, Paola, Dignetti, Paola, Bignardi, Donatella, Nedelea, Irena, Popescu, Florin-Dan, Vieru, Mariana, Secureanu, Florin-Adrian, Ganea, Carmen S, Vieira, Miguel, Silva, José P M, Watts, Timothy, Watts, Sophia, Lomikovska, Marta, Peredelskaya, Marina, Nenasheva, Natalia, Filipovic, Ivana, Zivkovic, Zorica, Filipovic, Djordje, Higgs, Jennette, Warner, Amena, Jones, Carla, Pouessel, Guillaume, Claverie, Claire, Labreuche, Julien, Renaudin, Jean-Marie, Dorkenoo, Aimée, Eb, Mireille, Moneret-Vautrin, Anne, Deschildre, Antoine, Leteurtre, Stephane, Grabenhenrich, Linus, Worm, Margitta, Dölle, Sabine, Scherer, Kathrin, Hutteger, Isidor, Christensen, Morten, Bindslev-Jensen, Carsten, Mortz, Charlotte, Eller, Esben, Kjaer, Henrik F, Carneiro-Leão, Leonor, Badas, Jenny, Coimbra, Alice, Levy, Dikla P, Ben-Shoshan, Moshe, Rimon, Ayelet, Benor, Shira, Arends, Nicolette J T, Edelbroek, Nikki, de Groot, Hans, Emons, Joyce A M, Brand, H. K A, Verhoeven, Dirk, van Veen, Leonieke N, de Jong, Nicolette W, Noh, Geunwoong, Jang, Eun H, Pascal, Mariona, Dominguez, Olga, Piquer, Mònica, Alvaro, Montserrat, Jimenez-Feijoo, Rosa, Lozano, Jaime, Machinena, Adriana, del Mar Folqué, Maria, Giner, Maria T, Plaza, Ana M, Turner, Paul, Patel, Nandinee, Vazquez-Ortiz, Marta, Lindsley, Sarah, Walker, Lucy, Rosenberg, Simon, Mari, Adriano, Alessandri, Claudia, Giangrieco, Ivana, Tuppo, Lisa, Rafaiani, Chiara, Mitterer, Georg, Ciancamerla, Michela, Ferrara, Rosetta, Bernardi, Maria L, Zennaro, Danila, Tamburrini, Maurizio, Ciardiello, Maria A, Harwanegg, Christian, Fernandez, Antonio, Selb, Regina, Egenmann, Philippe, Epstein, Michelle, Hoffmann-Sommergruber, Karin, Koning, Frits, Lovik, Martinus, Clare Mills, E. N, Moreno, Javier, van Loveren, Henk, Wal, Jean-Michel, Diesner, Susanne, Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera E, Starkl, Philipp, Endesfelder, David, Eiwegger, Thomas, Szepfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, Untersmayr, Eva, Wille, Soren, Meyer, Peter, Klingebiel, Caroline, Lidholm, Jonas, Ehrenberg, Angelica, Östling, Jonas, Cleach, Isabelle, Mège, Jean-Louis, Vitte, Joana, Aina, Roberta, Dubiela, Pawel, Pfeifer, Sabine, Bublin, Merima, Radauer, Christian, Humeniuk, Piotr, Kabasser, Stefan, Asero, Riccardo, Bogas, Gador, Gomez, Francisca, Campo, Paloma, Salas, Maria, Doña, Inmaculada, Barrionuevo, Esther, Guerrero, Maria A, Mayorga, Cristobalina, Prieto, Ana, Barber, Domingo, Torres, Maria J, Jamin, Annette, Wangorsch, Andrea, Ballmer, Barbara, Vieths, Stefan, Scheurer, Stephan, Apostolovic, Danijela, Mihailovic, Jelena, Krstic, Maja, Starkhammar, Maria, Velickovic, Tanja C, Hamsten, Carl, van Hage, Marianne, van Erp, Francine C, Knol, Edward F, Kansen, Hannah M, Pontoppidan, Bo, Meijer, Yolanda, van der Ent, Cornelis K, Knulst, André C, Sayers, Rebekah, Brown, Helen, Custovic, Adnan, Simpson, Angela, Mills, Claire, Schulz, Juliane, Akkerdaas, Jaap, Totis, Muriel, Capt, Annabelle, Herouet-Guicheney, Corinne, van Ree, Ronald, Banerjee, Tushar, Banerjee, Antima, Claude, Mathilde, Bouchaud, Grégory, Lupi, Roberta, Castan, Laure, Tranquet, Olivier, Denery-Papini, Sandra, Bodinier, Marie, Brossard, Chantal, De Poi, Rosella, Gritti, Elisa, De Dominicis, Emiliano, Popping, Bert, de Laureto, Patrizia P, Palosuo, Kati, Kukkonen, Anna K, Pelkonen, Anna, Mäkelä, Mika, Lee, Nanju A, Rost, Johanna, Muralidharan, Sridevi, Campbell, Dianne, Mehr, Sam, Nock, Catherine, Baumert, Joseph, Taylor, Steve, Mastrorilli, Carla, Tripodi, Salvatore, Caffarelli, Carlo, Perna, Serena, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Dondi, Arianna, Bianchi, Annamaria, Dascola, Carlotta P, Ricci, Giampaolo, Cipriani, Francesca, Maiello, Nunzia, del Giudice, Michele M, Frediani, Tullio, Frediani, Simone, Macrì, Francesco, Pistoletti, Chiara, Iacono, Iride D, Patria, Maria F, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Olcese, Roberta, Moretti, Matteo, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Verga, Maria C, Calvani, Mauro, Giordani, Paolo, Matricardi, Paolo M, Ontiveros, Noe, Cabrera-Chavez, Francisco, Galand, Julie, Beaudouin, Etienne, Pineau, Florence, Sakai, Shinobu, Matsunaga, Kayoko, Teshima, Reiko, Larré, Colette, Denery, Sandra, Tschirner, Sebastian, Trendelenburg, Valérie, Schulz, Gabriele, Niggemann, Bodo, Beyer, Kirsten, Bouferkas, Youcef, Belabbas, Younes, Saidi, Djamel, Kheroua, Omar, Mecherfi, Kamel E E, Guendouz, Malika, Haddi, Abir, Kaddouri, Hanane, Amaral, Luis, Pereira, Ana, Rodrigues, Susana, Datema, Mareen, Jongejan, Laurian, Clausen, Michael, Knulst, Andre, Papadopoulos, Nikolaos, Kowalski, Marek, de Blay, Frédéric, Zwinderman, Aeilko, Hoffman-Sommergruber, Karin, Ballmer-Weber, Barbara, Fernandez-Rivas, Montserrat, Deng, Shan, Yin, Jia, Eisenmann, Charlotte, Nassiri, Maria, Reinert, Rabea, van der Valk, Johanna P M, van Wijk, Roy G, Vergouwe, Yvonne, Steyerberg, Ewout W, Reitsma, Marit, Wichers, Harry J, Savelkoul, Huub F J, Vlieg-Boerstra, Berber, Dubois, Anthony E J, Carolino, Fabrícia, Rodolfo, Ana, Cernadas, Josefina, Roa-Medellín, Dasha, Rodriguez-Fernandez, Ana, Navarro, Joaquín, Albendiz, Vicente, Baeza, María L, Intente-Herrero, Sonsoles, Mikkelsen, Andrea, Mehlig, Kirsten, Lissner, Lauren, Verrill, Linda, Luccioli, Stefano, van Bilsen, Jolanda, Kuper, Frieke, Wolterbeek, André, Rankouhi, Tanja R, Verschuren, Lars, Cnossen, Hilde, Jeurink, Prescilla, Garssen, Johan, Knippels, Léon, Garthoff, Jossie, Houben, Geert, Leeman, Winfried, Eleonore Pettersson, M., Schins, Afke M M, Koppelman, Gerard H, Kollen, Boudewjin J, Zubchenko, Svitlana, Kuntz, Sarah, Mérida, Pablo, Álvaro, Montserrat, Piquer, Monica, Riggioni, Carmen, Castellanos, Juan H, Jimenez, Rosa, Cap, Melanie, Drumez, Elodie, Lejeune, Stéphanie, Thumerelle, Caroline, Mordacq, Clémence, Nève, Véronique, Ricò, Sonia, Varini, Margherita, Nocerino, Rita, Cosenza, Linda, Amoroso, Antonio, Di Costanzo, Margherita, Di Scala, Carmen, Bedogni, Giorgio, Canani, Roberto B, Turner, Paul J, Poza-Guedes, Paloma, González-Pérez, Ruperto, Sánchez-Machín, Inmaculada, Matheu-Delgado, Victor, Wambre, Erik, Ballegaard, Anne-Sofie, Madsen, Charlotte, Gregersen, Juliane, Bøgh, Katrine L, Aubert, Philippe, Neunlist, Michel, Magnan, Antoine, Lozano-Ojalvo, Daniel, Pablos-Tanarro, Alba, Pérez-Rodríguez, Leticia, Molina, Elena, López-Fandiño, Rosina, Rekima, Akila, Macchiaverni, Patricia, Turfkruyer, Mathilde, Holvoet, Sebastien, Dupuis, Lénaïck, Baiz, Nour, Annesi-Maesano, Isabella, Mercenier, Annick, Nutten, Sophie, Verhasselt, Valérie, Mrakovcic-Sutic, Ines, Banac, Srdan, Sutic, Ivana, Baricev-Novakovic, Zdenka, Sutic, Ingrid, Pavisic, Valentino, Muñoz-Cano, Rosa, Jiménez-Rodríguez, Teodoríkez, Corbacho, Daniel, Roca-Ferrer, Jordi, Bartra, Joan, Bulog, Aleksandar, Micovic, Vladimir, Markiewicz, Lidia, Szymkiewicz, Agata, Szyc, Anna, Wróblewska, Barbara, Harvey, Bryan M, Harthoorn, Lucien F, Wesley Burks, A., Rentzos, Georgios, Björk, Anna-Lena B, Bengtsson, Ulf, Barber, Colin, Kalicinsky, Chrystyna, Breynaert, Christine, Coorevits, Lieve, Jansen, Cornelia, Van Hoeyveld, Erna, Verbeke, Kristin, Kochuyt, Anne-Marie, Schrijvers, Rik, Deleanu, Diana, Muntean, Adriana, Konstantakopoulou, Maria, Pasioti, Maria, Papadopoulou, Anastasia, Iliopoulou, Anna, Mikos, Nikolaos, Kompoti, Evangelia, de Castro, Eunice D, Bartalomé, Borja, Ue, Kok L, Griffiths, Elizabeth, Till, Stephen, Grimshaw, Kate, Roberts, Graham, Selby, Anna, Butiene, Indre, Larco, Jose I, Dubakiene, Ruta, Fiandor, Ana, Fiocchi, Alessandro, Papadopoulos, Nikos, Sigurdardottir, Sigurveig, Sprikkelman, Aline, Schoemaker, Anne-Fleur, Xepapadaki, Paraskevi, Keil, Thomas, Cojocariu, Zizi, Barbado, Beatriz S, Iancu, Vasti, Arroabarren, Esozia, Esarte, Marta G, Arteaga, Miren, Andrade, Mayra C, Borges, Denise, Kalil, Jorge, Bianchi, Pedro G, Agondi, Rosana C, Gupta, Rinkesh K, Sharma, Akanksha, Gupta, Kriti, Das, Mukul, Dwivedi, Premendra, Karseladze, Rusudan, Jorjoliani, Liana, Saginadze, Lali, Tskhakaia, Mariam, Basello, Katia, Piuri, Gabriele, Speciani, Attilio F, Speciani, Michela C, Camerotto, Carla, Zinno, Francesco, Pakholchuk, Olga, Nedelska, Svitlana, Pattini, Stefano, Costantino, Maria T, Peveri, Silvia, Villalta, Danilo, Savi, Eleonora, Costanzi, Andrea, Revyakina, Vera A, Kiseleva, Marina A, Kuvshinova, Elena D, Larkova, Inna A, Shekhetov, Anton A, Silva, Diana, Moreira, André, Plácido, José, van der Kleij, Hanneke, van Twuijver, Esther, Sutorius, Robbert, de Kam, Pieter-Jan, van Odijk, Jenny, Lindqvist, Helen, Lustig, Elin, Jácome, Amyra A A, Aguilar, Karla L B, Domínguez, Miguel G, Hernández, David A M, Caruso, Cristiano, Casale, Cono, Rapaccini, Gian L, Romano, Antonino, De Vitis, Italo, Cocco, Renata R, Aranda, Carolina, Mallozi, Marcia C, Motta, Jackeline F, Moraes, Lilian, Pastorino, Antonio, Rosario, Nelson, Goudouris, Ekaterini, Porto, Arnaldo, Wandalsen, Neusa F, Sarinho, Emanuel, Sano, Flavio, Solé, Dirceu, Pitsios, Constantinos, Petrodimopoulou, Maria, Papadopoulou, Ekaterini, Passioti, Maria, Kontogianni, Meropi, Adamia, Nino, Khaleva, Ekaterina, del Prado, Ana P, Du Toit, George, Krzych, Edyta, Samolinska-Zawisza, Urszula, Furmanczyk, Konrad, Tomaszewska, Aneta, Raciborski, Filip, Lipiec, Agnieszka, Samel-Kowalik, Piotr, Walkiewicz, Artur, Borowicz, Jacek, Samolinski, Boleslaw, Nano, Aimee L, Recto, Marysia, Somoza, Maria L, López, Natalia B, Alzate, Diana P, Ruano, Francisco J, Garcimartín, Maria I, Haroun, Elisa, de la Torre, Maria V, Rojas, Antonia, Onieva, Montserrat L, Canto, Gabriela, Rodrigues, Alexandra, Forno, Andreia, Cabral, António J, Gonçalves, Rute, Vorozhko, Ilya, Sentsova, Tatyana, Chernyak, Olga, Denisova, Svetlana, Ilènko, Lidia, Muhortnich, Valery, Zimmermann, Caroline, Rohrbach, Alexander, Bakhsh, Faisal R, Boudewijn, Kollen, Oomkes-Pilon, Anne-Marie, Van Ginkle, Dorien, Šilar, Mira, Jeverica, Anja, Vesel, Tina, Avčin, Tadej, Korošec, Peter, van der Valk, Johanna, Berends, Irene, Arends, Nicolette, van Maaren, Maurits, Wichers, Harry, Emons, Joyce, Dubois, Anthony, de Jong, Nicolette, Matsyura, Oksana, Besh, Lesya, Huang, Chung-Hsiung, Jan, Tong-Rong, Stiefel, Gary, Tratt, Jean, Kirk, Kerrie, Carolino, Fabricia, Arasi, Stefania, Caminiti, Lucia, Crisafulli, Giuseppe, Fiamingo, Chiara, Fresta, Jlenia, Pajno, Giovanni, Remington, Ben, Kruizinga, Astrid, Marty Blom, W., Westerhout, Joost, Bijlsma, Sabina, Baumert, Joe, Blankestijn, Mark, Otten, Henny, Klemans, Rob, Michelsen-Huisman, Anouska D, van Os-Medendorp, Harmieke, Kruizinga, Astrid G, Versluis, Astrid, van Duijn, Gert, de Zeeuw-Brouwer, H. M, Castenmiller, Jacqueline J M, Noteborn, Hub P J M, Houben, Geert F, Bravin, Kristian, Luyt, David, Javed, Bushra, Couch, Phil, Munro, Christopher, Padfield, Phil, Sperrin, Matt, Byrne, Aideen, Oosthuizen, Lizalet, Kelleher, Carina, Ward, Fiona, Brosnan, Niamh, King, Graham, Corbet, Eva, Guzmán, Josué A H, García, Montserrat B, Asensio, Oscar, Navarrete, Laura V, Larramona, Helena, Miró, Xavier D, Pyrz, Katarzyna, Austin, Moira, Boloh, Yanne, Couch, Philip, Galloway, Deirdre, Hernandez, Pilar, Hourihane, Jonathan O, Kenna, Fiona, Majkowska-Wojciechowska, Barbara, Regent, Lynne, Themisb, Marina, Schnadt, Sabine, Semic-Jusufagic, Aida, Galvin, Audrey D, Kauppila, Tiina, Kuitunen, Mikael, Kitsioulis, Nikolaos A, Douladiris, Nikolaos, Kostoudi, Sofia, Manolaraki, Ioanna, Mitsias, Dimitris, Manousakis, Emmanouil, Papadopoulos, Nikolaos G, Knibb, Rebecca, Hammond, Jennifer, Cooke, Richard, Yrjänä, Jaakko, Hanni, Anna-Maija, Vähäsarja, Päivi, Mustonen, Oona, Dunder, Teija, Kulmala, Petri, Lasa, Eva, D’Amelio, Carmen, Martínez, Sara, Joral, Alejandro, Gastaminza, Gabriel, Goikoetxea, Maria J, Candy, David C A, Van Ampting, Marleen T J, Oude Nijhuis, Manon M, Butt, Assad M, Peroni, Diego G, Fox, Adam T, Knol, Jan, Michaelis, Louise J, Padua, Ines, Padrao, Patricia, Moreira, Pedro, Barros, Renata, Sharif, Hanan, Ahmed, Manzoor, Gomaa, Nehad, Mens, Joris, Smit, Koen, Timmermans, Frans, Poredoš, Tomaž, Jeverica, Anja K, Sedmak, Marjeta, Benedik, Evgen, Accetto, Meta, Zupančič, Mirjana, Yonamine, Glauce, Soldateli, Gustavo, Aquilante, Bruna, Pastorino, Antonio C, de Moraes Beck, Cleonir L, Gushken, Andrea K, de Barros Dorna, Mayra, dos Santos, Cristiane N, Castro, Ana P M, Al-Qahtani, Abdulhadi, Arnaout, Rand, Khaliq, Agha R, Amin, Rashid, Sheikh, Farrukh, Alvarez, Jorge, Anda, Marta, Palacios, Miriam, De Prada, Montserrat, Ponce, Carmen, Balbino, Bianca, Sibilano, Riccardo, Marichal, Thomas, Gaudenzio, Nicolas, Karasuyama, Hajime, Bruhns, Pierre, Tsai, Mindy, Reber, Laurent L, Galli, Stephen J, Ferreira, Ana R, Cernadas, Josefina R, del Campo García, Aida, Fernández, Sara P, Carrera, Nerea S, Sánchez-Cruz, Fernando B, Lorenzo, José R F, Claus, Stephanie, Pföhler, Claudia, Ruëff, Franziska, Treudler, Regina, Jaume, Mercedes E, Madroñero, Agustin, Perez, Maria T G, Julia, Juan C, Plovdiv, Charlotte H, Gethings, Lee, Langridge, Jim, Adel-Patient, Karine, Bernard, Hervé, Barcievic-Jones, Ivona, Sokolova, Raditsa, Yankova, Rumyana, Ivanovska, Mariya, Murdjeva, Marianna, Popova, Tatyana, Dermendzhiev, Svetlan, Karjalainen, Martin, Lehnigk, Ulrike, Brown, Duncan, Locklear, Julie C, Locklear, Julie, Maris, Ioana, Hourihane, Jonathan, Ornelas, Cristina, Caiado, Joana, Ferreira, Manuel B, Pereira-Barbosa, Manuel, Puente, Yolanda, Daza, Juan C, Monteseirin, Francisco J, Ukleja-Sokolowska, Natalia, Gawronska-Ukleja, Ewa, Zbikowska-Gotz, Magdalena, Bartuzi, Zbigniew, Sokolowski, Lukasz, Adams, Aine, Mahon, Bernard, English, Karen, Gourdon-Dubois, Nelly, Sellam, Laetitia, Pereira, Bruno, Michaud, Elodie, Messaoudi, Khaled, Evrard, Bertrand, Fauquert, Jean-Luc, Palomares, Francisca, Gomez, Gador, Rodriguez, Maria J, Galindo, Luisa, Molina, Ana, Paparo, Lorella, Mennini, Maurizio, Aitoro, Rosita, Wawrzeńczyk, Adam, Przybyszewski, Michał, Wawrzeńczyk, Anna, Sarıcoban, Hulya E, Ugras, Meltem, Yalvac, Zerrin, Flokstra-de Blok, Bertine M J, van der Velde, J. L, Vereda, Andrea, Ippolito, Clara, Traversa, Amaranta, Adriano, Daniela, Bianchi, Daniela M, Gallina, Silvia, Decastelli, Lucia, Makatsori, Melina, Miles, Anne, Devetak, Sonja P, Devetak, Iztok, Tabet, Soraya A, Trandbohus, Jeanette F, Winther, Pernille, Malling, Hans-Jørgen, Hansen, Kirsten S, Garvey, Lene H, Wang, Chia-Chi, Cheng, Yin-Hua, Tung, Chun-Wei, Dietrich, Mariola, Marenholz, Ingo, Kalb, Birgit, Grosche, Sarah, Blümchen, Katharina, Schlags, Rupert, Price, Mareike, Rietz, Sylke, Esparza-Gordillo, Jorge, Lau, Susanne, Lee, Young-Ae, Almontasheri, Ali, Bahkali, Mohammad A, Elshorbagi, Sahar, Alfhaid, Abdullah, Altamimi, Mashary, Madbouly, Eman, Al-Dhekri, Hassan, Arnaout, Rand K, Basagaña, Maria, Miquel, Sira, Bartolomé, Borja, Brix, Bettina, Rohwer, Stefanie, Brandhoff, Sandra, Berger, Alena, Suer, Waltraud, Weimann, Alf, Bueno, Cristina, Martín-Pedraza, Laura, Abián, Sara, Segundo-Acosta, Pablo S, López-Rodríguez, Juan C, Barderas, Rodrigo, Batanero, Eva, Cuesta-Herranz, Javier, Villalba, María T, Correia, Magna, Benito-Garcia, Filipe, Arêde, Cristina, Piedade, Susana, Morais-Almeida, Mário, Hindley, James, Yarham, Ross, Kuklinska-Pijanka, Anna, Gillick, David, Patient, Karine, Chapman, Martin D, Miranda, Ana, Matos, Eugénia, Sokolova, Anna, Rao, Huan, Baricevic-Jones, Ivona, Smith, Frances, Xue, Wentong, Magnusdottir, Helga, Vidarsdottir, Anna G, Lund, Sigrun, Jensen, Anders B, Ludviksson, Bjorn R, Simon, Reyna, Elfont, Robert, Bennett, Sean, Voyksner, Robert, de Lurdes Torre, Maria, Yürek, Songül, Faber, Margaretha A, Bastiaensen, Annick, Mangodt, Evelyne, van Gasse, Athina, Decuyper, Ine, Sabato, Vito, Hagendorens, Margo M, Bridts, Chris H, De Clerck, Luc S, Ebo, Didier, Schwarz, Susanne, Ziegert, Mandy, Albroscheit, Saskia, Schwager, Christian, Kull, Skadi, Behrends, Jochen, Röckendorf, Niels, Schocker, Frauke, Frey, Andreas, Homann, Arne, Becker, Wolf-Meinhard, Jappe, Uta, Zaabat, Nesrine, Osscini, Sylvia, Agabriel, Chantal, Sterling, Benoît, Carsin, Ania, Liabeuf, Valérie, Maćków, Monica, Zbróg, Alina, Bronkowska, Monica, Courtois, Justine, Gadisseur, Romy, Bertholet, Catherine, Lukas, Pierre, Cavalier, Etienne, Delahaut, Philippe, Quinting, Birgit, Gertmo, Margareta B, Hasseus, Ewa T, Barzylovych, Vladyslava, Oliveira, Júlio, Ensina, Luis F, Aranda, Carolina S, Dopazo, Leire, Lopez, Rebeca, Perez, Raquel, Santos-Diez, Laura, Bilbao, Agurtzane, Garcia, Juan M, Núñez, Ignacio G, Mármol, María Á A, Villarejo, María J B, Martos, José A B, Vergara, Marina S, García, José M I, Michalska, Agata, Sergiejko, Grzegorz, Zacniewski, Robert, Ghiordanescu, Ileana-Maria, Deaconu, Cristina, Popescu, Mihaela, Bumbacea, Roxana S, Ibranji, Alkerta, Nikolla, Elida, Loloci, Gjustina, Juel-Berg, Nanna, Larsen, Lau F, Poulsen, Lars K, Marcelino, João, Prata, Ricardo, Costa, Ana C, Duarte, Fátima, Neto, Marta, Santos, Jennifer, Pestana, Luís C, Sampaio, Daniel, Minale, Paola, Dignetti, Paola, Bignardi, Donatella, Nedelea, Irena, Popescu, Florin-Dan, Vieru, Mariana, Secureanu, Florin-Adrian, Ganea, Carmen S, Vieira, Miguel, Silva, José P M, Watts, Timothy, Watts, Sophia, Lomikovska, Marta, Peredelskaya, Marina, Nenasheva, Natalia, Filipovic, Ivana, Zivkovic, Zorica, Filipovic, Djordje, Higgs, Jennette, Warner, Amena, and Jones, Carla

Published
2017

46. Perinatal probiotic intervention prevented allergic disease in a Caesarean‐delivered subgroup at 13‐year follow‐up.

Author

Kallio, Sampo, Kukkonen, Anna Kaarina, Savilahti, Erkki, and Kuitunen, Mikael

Subjects
*ALLERGIES, *WHEEZE, *PREGNANT women, *DISEASE prevalence, *PREVENTIVE medicine, *BLOOD sampling
Abstract

Summary: Background: The long‐term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial. Objective: To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age. Methods: Pregnant women (n = 1223) carrying a child at a high risk of allergy (at least one parent with allergic disease) were randomized to receive a mixture of probiotics (Lactobacillus rhamnosusGG and LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii) or placebo in a double‐blind manner from 36 weeks of gestation until birth. Their infants received the same product for the first six months (registration number NCT00298337). At 13‐year follow‐up, the participants were requested to return a questionnaire and to provide a blood sample. Results: A questionnaire was returned by 642 participants (63.1% of intention‐to‐treat infants), and 459 provided a blood sample. In the whole cohort, there were no statistically significant differences in doctor‐diagnosed allergic disease (55.2% and 59.0%, probiotic and placebo group, respectively) or allergic disease (47.9% and 51.6%) based on the ISAAC questionnaire data. Inhalant‐specific IgE sensitization (>0.7 kU/L) was 59.3% in the probiotic group and 49.8% in the placebo group (P = 0.040). In a post hoc analysis made in Caesarean‐delivered subgroup, allergy was reported in 41.5% of the probiotic group and 67.9% of the placebo group (P = 0.006), and eczema in 18.9% and 37.5%, respectively (P = 0.031). In the whole cohort, 8.5% of the probiotic group had suffered from wheezing attacks during the previous 12 months vs 14.7% in the placebo group (P = 0.013). There were no statistically significant differences discovered between the characteristics of the participating group and the dropout group. Conclusions: Probiotic intervention protected Caesarean‐delivered subgroup from allergic disease and eczema, but not the total cohort. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

48. Autovasta-aineiden esiintyvyys epilepsiaa sairastavilla lapsilla

Author

KUKKONEN, ANNA, Lääketieteen yksikkö - School of Medicine, and University of Tampere

Subjects
immuunijärjestelmä, kohtausoire, antifosfolipidi, Lääketiede - Medicine, epileptogeneesi
Abstract

Epilepsia on monitekijäinen aivojen kohtauksellinen sairaus, ja sen syntyyn on liitetty monia geneettisiä ja ympäristö-riippuvaisia tekijöitä. Immuunijärjestelmän toimintahäiriöiden ja epilepsian välistä yhteyttä on tutkittu, ja tavoitteena on ollut löytää epilepsian ilmaantumista ja vaikeahoitoisuutta ennustavia tekijöitä immuunijärjestelmän mitattavissa olevista parametreista. Tämän tutkimuksen tarkoituksena oli selvittää immuunijärjestelmän toimintahäiriöiden merkitystä lapsuusiän epilepsian etiologiana ja vaikeahoitoisuutta ennustavana tekijänä. Tutkimuksessa pyrittiin selvittämään mm. autovasta-aineiden ja immuunijärjestelmän toimintahäiriöiden ilmaantumisajankohtaa ja pysyvyyttä. Tutkimus on osa tutkimuskokonaisuutta, jonka ensimmäisessä jo julkaistussa osassa (Eriksson et al. 2001) selvitettiin tiettyjen immuunijärjestelmän toimintaa kuvaavien muuttujien esiintymistä epilepsiaa sairastavilla lapsilla. Tässä tutkimuksen seuraavassa osassa on käsitelty ensimmäisessä osassa olleiden tutkimuspotilaiden seurantanäytteitä. Osaan 1. osallistuneista tutkimuspotilaista otettiin seurantanäytteet n. yhden ja kahden vuoden kuluttua (=kevät 2000 ja kevät 2001) ensimmäisistä näytteistä. Tässä seurantatutkimuksessa arvioitiin siis 1. osan luotettavuutta vertailemalla saatuja tuloksia, eli seurantanäytteitä. Tutkimusaineistossa eli 49 lapsipotilaan joukossa vähintään yhden vasta-aineen muutos tutkimusajan puitteissa havaittiin 26:lla lapsella, ja 13:lla oli enemmän kuin yksi poikkeava arvo. Vasta-ainetasoissa tapahtunutta muutosta tutkittiin mittaamalla kardiolipiini-, beta-2-glykoproteiini- 1- ja tumavasta-aineet lasten seeruminäytteistä yhden ja kahden vuoden päästä ensimmäisestä näytteestä. Edellä mainittujen vasta-ainetasojen muutoksia tarkasteltaessa käytettiin ristiintaulukointimenetelmää muutosten ja erilaisten muuttujien mahdollisten korrelaatioiden selvittämiseksi. Kardiolipiinivasta-aineet muuttuivat viidellä potilaalla seurannassa negatiivisiksi. Koko joukon tasolla merkittävää oli, että muutoksen negatiivinen suunta tai negatiivisena pysyminen korreloi matalaan epileptiseen kohtausaktiivisuuteen. Negatiivinen vasta-ainetaso seurannassa oli myös yhteydessä MRI-kuvien löydöksettömyyteen. B2GP1-vasta-aineet pysyivät seurannassa lähes koko populaatiolla negatiivisina. Negatiivisina pysyneiden vasta-aineiden ja kohtausfrekvenssin välillä havaittiin samankaltainen yhteys kuin aCL-vasta-aineillakin. Tumavasta-aineiden muutokset olivat aineistossa satunnaisia, mutta muutoksen suunta näytti merkitsevästi korreloivan potilaan sukupuoleen. Kokonaisuudessaan vasta-aineiden pysyvyydestä on tutkimuksen perusteella vaikea tehdä luotettavia johtopäätöksiä aineiston pienen koon takia. Mielenkiintoista kuitenkin on, että lapsuusiän epilepsian harva kohtausfrekvenssi näytti korreloivan vasta-ainenegatiivisuuden kanssa. Todennäköistä kuitenkin on, että lapsuusiän epilepsioissa havaittujen korkeiden vasta-ainetasojen merkitys epilepsian synnyssä ja tautiaktiivisuuden osoittajana on assosiatiivinen, ja liittyy vain joihinkin tiettyihin epilepsiasyndroomiin.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results