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1. SUCCOR morbidity: complications in minimally invasive versus open radical hysterectomy in early cervical cancer

Author

Vázquez-Vicente, Daniel, Boria, Felix, Castellanos, Teresa, Gutierrez, Monica, Chacon, Enrique, Manzour, Nabil, Minguez, Jose Angel, Martin-Calvo, Nerea, Alcazar, Juan Luis, Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Arévalo-Serrano, Juan, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Aliyev, Shamistan, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Abdalla, Nabil, Akbayir, Özgür, Akgöl, Sedat, Aksahin, Elif, Alonso-Espias, Maria, Aluloski, Igor, Andrade, Claudia, Badzakov, Nikola, Barrachina, Rosa, Bogani, Giorgio, Bonci, Eduard-Aexandru, Bonsang-Kitzis, Hélène, Brucker, Cosima, Cárdenas, Laura, Casajuana, Andrea, Cavalle, Pere, Cea, Jorge, Chiofalo, Benito, Cordeiro, Gloria, Coronado, Pluvio, Cuadra, Maria, Díez, Javier, Costa, Teresa Diniz da, Domingo, Santiago, Dostalek, Lukas, Demirkiran, Fuat, Erasun, Diego, Fehr, Mathias, Fernandez-Gonzalez, Sergi, Ferrero, Annamaria, Fidalgo, Soledad, Fiol, Gabriel, Galaal, Khadra, García, José, Gebauer, Gerhard, Ghezzi, Fabio, Gilabert, Juan, Gomes, Nana, Gonçalves, Elisabete, Gonzalez, Virginia, Grandjean, Frederic, Guijarro, Miriam, Guyon, Frédéric, Haesen, Jolien, Hernandez-Cortes, Gines, Herrero, Sofía, Pete, Imre, Kalogiannidis, Ioannis, Karaman, Erbil, Kavallaris, Andreas, Klasa, Lukasz, Kotsopoulos, Ioannis, Kovachev, Stefan, Leht, Meelis, Lekuona, Arantxa, Luyckx, Mathieu, Mallmann, Michael, Mancebo, Gemma, Mandic, Aljosa, Marina, Tiermes, Martin, Victor, Martín-Salamanca, María Belén, Martinez, Alejandra, Meili, Gesine, Mendinhos, Gustavo, Mereu, Liliana, Mitrovic, Milena, Morales, Sara, Moratalla, Enrique, Morillas, Bibiana, Myriokefalitaki, Eva, PakižImre, Maja, Petousis, Stamatios, Pirtea, Laurentiu, Povolotskaya, Natalia, Prader, Sonia, Quesada, Alfonso, Redecha, Mikuláš, Roldan, Fernando, Rolland, Philip, Saaron, Reeli, Sarac, Cosmin-Paul, Scharf, Jens-Peter, Smrkolj, Špela, Sousa, Rita, Stepanyan, Artem, Študent, Vladimír, Tauste, Carmen, Trum, Hans, Turan, Taner, Undurraga, Manuela, Uppin, Arno, Vázquez, Alicia, Vergote, Ignace, Vorgias, George, Zapardiel, Ignacio, and Campillo, Francisco

Published
2024
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2. SUCCOR quality: validation of ESGO quality indicators for surgical treatment of cervical cancer

Author

Boria, Felix, Chiva, Luis, Chacon, Enrique, Zanagnolo, Vanna, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Zusterzeel, Petra L M, Aluloski, Igor, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Bernardino, Margarida, Bharathan, Rasiah, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Demirkiran, Fuat, Vorgias, George, Povolotskaya, Natalia, Coronado Martín, Pluvio J, Marina, Tiermes, Zapardiel, Ignacio, Bizzarri, Nicolò, Gorostidi, Mikel, Gutierrez, Monica, Manzour, Nabil, Berasaluce, Arantxa, and Martin-Calvo, Nerea

Published
2022
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3. SUCCOR cone study: conization before radical hysterectomy

Author

Chacon, Enrique, Manzour, Nabil, Zanagnolo, Vanna, Querleu, Denis, Núñez-Córdoba, Jorge M, Martin-Calvo, Nerea, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Gil Moreno, Antonio, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Boria, Felix, Alcazar, Juan Luis, Chiva, Luis, Abdalla, Nabil, Akgöl, Sedat, Aksahin, Demirkiran, Aliyev, Shamistan, Alonso-Espias, Maria, Aluloski, Igor, Andrade, Claudia, Badzakov, Nikola, Barrachina, Rosa, Bogani, Giorgio, Bonci, Eduard-Aexandru, Bonsang-Kitzis, Hélène, Brucker, Cosima, Cárdenas, Laura, Casajuana, Andrea, Cavalle, Pere, Cea, Jorge, Chiofalo, Benito, Cordeiro, Gloria, Coronado, Pluvio, Cuadra, Maria, Díez, Javier, Costa, Teresa Diniz da, Domingo, Santiago, Dostalek, Lukas, Elif, Fuat, Erasun, Diego, Fehr, Mathias, Fernandez-Gonzalez, Sergi, Ferrero, Annamaria, Fidalgo, Soledad, Fiol, Gabriel, Galaal, Khadra, García, José, Gebauer, Gerhard, Ghezzi, Fabio, Gilabert, Juan, Gomes, Nana, Gonçalves, Elisabete, Gonzalez, Virginia, Grandjean, Frederic, Guijarro, Miriam, Guyon, Frédéric, Haesen, Jolien, Hernandez-Cortes, Gines, Herrero, Sofía, Pete, Imre, Kalogiannidis, Ioannis, Karaman, Erbil, Kavallaris, Andreas, Klasa, Lukasz, Kotsopoulos, Ioannis, Kovachev, Stefan, Leht, Uppin Arno, Lekuona, Arantxa, Luyckx, Mathieu, Mallmann, Michael, Mancebo, Gemma, Mandic, Aljosa, Marina, Tiermes, Martin, Victor, Martín-Salamanca, María Belén, Lago, Víctor, Martinez, Alejandra, Meili, Gesine, Mendinhos, Gustavo, Mereu, Liliana, Mitrovic, Milena, Morales, Sara, Moratalla, Enrique, Gómez-Hidalgo, Natalia R, Morillas, Bibiana, Myriokefalitaki, Eva, PakižImre, Maja, Petousis, Stamatios, Pirtea, Laurentiu, Povolotskaya, Natalia, Prader, Sonia, Quesada, Alfonso, Redecha, Mikuláš, Roldan, Fernando, Rolland, Philip, Saaron, Reeli, Sarac, Cosmin-Paul, Scharf, Jens-Peter, Smrkolj, Špela, Sousa, Rita, Stepanyan, Artem, Študent, Vladimír, Tauste, Carmen, Trum, Hans, Turan, Taner, Undurraga, Manuela, Vázquez, Alicia, Vergote, Ignace, Vorgias, George, and Zapardiel, Ignacio

Published
2022
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4. Radical hysterectomy in early cervical cancer in Europe: characteristics, outcomes and evaluation of ESGO quality indicators

Author

Boria, Felix, Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Martin-Calvo, Nerea, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Alonso-Espías, María, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Manzour, Nabil, Jurado, Matias, Castellanos, Teresa, Chacon, Enrique, and Alcazar, Juan Luis

Published
2021
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5. SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer

Author

Abdalla, Nabil, Akbayir, Özgür, Akgöl, Sedat, Aksahin, Elif, Aliyev, Shamistan, Alonso-Espias, Maria, Aluloski, Igor, Andrade, Claudia, Badzakov, Nikola, Barrachina, Rosa, Bogani, Giorgio, Bonci, Eduard-Aexandru, Bonsang-Kitzis, Hélène, Boria, Felix, Brucker, Cosima, Cárdenas, Laura, Casajuana, Andrea, Cavalle, Pere, Cea, Jorge, Chiofalo, Benito, Cordeiro, Gloria, Coronado, Pluvio, Cuadra, Maria, Díez, Javier, Costa, Teresa Diniz da, Domingo, Santiago, Dostalek, Lukas, Demirkiran, Fuat, Erasun, Diego, Fehr, Mathias, Fernandez-Gonzalez, Sergi, Ferrero, Annamaria, Fidalgo, Soledad, Fiol, Gabriel, Galaal, Khadra, García, José, Gebauer, Gerhard, Ghezzi, Fabio, Gilabert, Juan, Gomes, Nana, Gonçalves, Elisabete, Gonzalez, Virginia, Grandjean, Frederic, Guijarro, Miriam, Guyon, Frédéric, Haesen, Jolien, Hernandez-Cortes, Gines, Herrero, Sofía, Pete, Imre, Kalogiannidis, Ioannis, Karaman, Erbil, Kavallaris, Andreas, Klasa, Lukasz, Kotsopoulos, Ioannis, Kovachev, Stefan, Leht, Meelis, Lekuona, Arantxa, Luyckx, Mathieu, Mallmann, Michael, Mancebo, Gemma, Mandic, Aljosa, Manzour, Nabil, Marina, Tiermes, Martin, Victor, Martín-Salamanca, María Belén, Martinez, Alejandra, Meili, Gesine, Mendinhos, Gustavo, Mereu, Liliana, Mitrovic, Milena, Morales, Sara, Moratalla, Enrique, Morillas, Bibiana, Myriokefalitaki, Eva, PakižImre, Maja, ImrePete, Stamatios Petousis, Pirtea, Laurentiu, Povolotskaya, Natalia, Prader, Sonia, Quesada, Alfonso, Redecha, Mikuláš, Roldan, Fernando, Rolland, Philip, Saaron, Reeli, Sarac, Cosmin-Paul, Scharf, Jens-Peter, Smrkolj, Špela, Sousa, Rita, Stepanyan, Artem, Študent, Vladimír, Tauste, Carmen, Trum, Hans, Turan, Taner, Undurraga, Manuela, Uppin, Arno, Vázquez, Alicia, Vergote, Ignace, Vorgias, George, Zapardiel, Ignacio, Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Martin-Calvo, Nerea, Arévalo-Serrano, Juan, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Chacon, Enrique, and Alcazar, Juan Luis

Published
2020
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6. SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer

Author

Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Martin-Calvo, Nerea, Arévalo-Serrano, Juan, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Aliyev, Shamistan, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Chacon, Enrique, and Alcazar, Juan Luis

Published
2020
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7. SUCCOR cone study: conization before radical hysterectomy

Author

Chacon, E, Manzour, N, Zanagnolo, V, Querleu, D, Núñez-Córdoba, J, Martin-Calvo, N, Căpîlna, M, Fagotti, A, Kucukmetin, A, Mom, C, Chakalova, G, Shamistan, A, Gil Moreno, A, Malzoni, M, Narducci, F, Arencibia, O, Raspagliesi, F, Toptas, T, Cibula, D, Kaidarova, D, Meydanli, M, Tavares, M, Golub, D, Perrone, A, Poka, R, Tsolakidis, D, Vujić, G, Jedryka, M, Zusterzeel, P, Beltman, J, Goffin, F, Haidopoulos, D, Haller, H, Jach, R, Yezhova, I, Berlev, I, Bernardino, M, Bharathan, R, Lanner, M, Maenpaa, M, Sukhin, V, Feron, J, Fruscio, R, Kukk, K, Ponce, J, Minguez, J, Vázquez-Vicente, D, Castellanos, T, Boria, F, Alcazar, J, Chiva, L, Chacon, Enrique, Manzour, Nabil, Zanagnolo, Vanna, Querleu, Denis, Núñez-Córdoba, Jorge M, Martin-Calvo, Nerea, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Gil Moreno, Antonio, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Boria, Felix, Alcazar, Juan Luis, Chiva, Luis, Chacon, E, Manzour, N, Zanagnolo, V, Querleu, D, Núñez-Córdoba, J, Martin-Calvo, N, Căpîlna, M, Fagotti, A, Kucukmetin, A, Mom, C, Chakalova, G, Shamistan, A, Gil Moreno, A, Malzoni, M, Narducci, F, Arencibia, O, Raspagliesi, F, Toptas, T, Cibula, D, Kaidarova, D, Meydanli, M, Tavares, M, Golub, D, Perrone, A, Poka, R, Tsolakidis, D, Vujić, G, Jedryka, M, Zusterzeel, P, Beltman, J, Goffin, F, Haidopoulos, D, Haller, H, Jach, R, Yezhova, I, Berlev, I, Bernardino, M, Bharathan, R, Lanner, M, Maenpaa, M, Sukhin, V, Feron, J, Fruscio, R, Kukk, K, Ponce, J, Minguez, J, Vázquez-Vicente, D, Castellanos, T, Boria, F, Alcazar, J, Chiva, L, Chacon, Enrique, Manzour, Nabil, Zanagnolo, Vanna, Querleu, Denis, Núñez-Córdoba, Jorge M, Martin-Calvo, Nerea, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Gil Moreno, Antonio, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Boria, Felix, Alcazar, Juan Luis, and Chiva, Luis

Abstract

OBJECTIVE: To evaluate disease-free survival of cervical conization prior to radical hysterectomy in patients with stage IB1 cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) 2009). METHODS: A multicenter retrospective observational cohort study was conducted including patients from the Surgery in Cervical Cancer Comparing Different Surgical Aproaches in Stage IB1 Cervical Cancer (SUCCOR) database with FIGO 2009 IB1 cervical carcinoma treated with radical hysterectomy between January 1, 2013, and December 31, 2014. We used propensity score matching to minimize the potential allocation biases arising from the retrospective design. Patients who underwent conization but were similar for other measured characteristics were matched 1:1 to patients from the non-cone group using a caliper width ≤0.2 standard deviations of the logit odds of the estimated propensity score. RESULTS: We obtained a weighted cohort of 374 patients (187 patients with prior conization and 187 non-conization patients). We found a 65% reduction in the risk of relapse for patients who had cervical conization prior to radical hysterectomy (hazard ratio (HR) 0.35, 95% confidence interval (CI) 0.16 to 0.75, p=0.007) and a 75% reduction in the risk of death for the same sample (HR 0.25, 95% CI 0.07 to 0.90, p=0.033). In addition, patients who underwent minimally invasive surgery without prior conization had a 5.63 times higher chance of relapse compared with those who had an open approach and previous conization (HR 5.63, 95% CI 1.64 to 19.3, p=0.006). Patients who underwent minimally invasive surgery with prior conization and those who underwent open surgery without prior conization showed no differences in relapse rates compared with those who underwent open surgery with prior cone biopsy (reference) (HR 1.94, 95% CI 0.49 to 7.76, p=0.349 and HR 2.94, 95% CI 0.80 to 10.86, p=0.106 respectively). CONCLUSIONS: In this retrospective study, patients undergoing cervical conizatio

Published
2022

8. SUCCOR cone study: conization before radical hysterectomy

Author

Chacon, Enrique Manzour, Nabil Zanagnolo, Vanna Querleu, Denis Nunez-Cordoba, Jorge M. Martin-Calvo, Nerea Capilna, Mihai Emil Fagotti, Anna Kucukmetin, Ali Mom, Constantijne and Chakalova, Galina Shamistan, Aliyev Gil Moreno, Antonio and Malzoni, Mario Narducci, Fabrice Arencibia, Octavio and Raspagliesi, Francesco Toptas, Tayfun Cibula, David and Kaidarova, Dilyara Meydanli, Mehmet Mutlu Tavares, Mariana and Golub, Dmytro Perrone, Anna Myriam Poka, Robert Tsolakidis, Dimitrios Vujic, Goran Jedryka, Marcin A. Zusterzeel, Petra L. M. Beltman, Jogchum Jan Goffin, Frederic Haidopoulos, Dimitrios Haller, Herman Jach, Robert Yezhova, Iryna and Berlev, Igor Bernardino, Margarida Bharathan, Rasiah Lanner, Maximilian Maenpaa, Minna M. Sukhin, Vladyslav Feron, Jean-Guillaume Fruscio, Robert Kukk, Kersti Ponce, Jordi and Angel Minguez, Jose Vazquez-Vicente, Daniel Castellanos, Teresa and Boria, Felix Luis Alcazar, Juan Chiva, Luis SUCCOR Study Grp

Abstract

Objective To evaluate disease-free survival of cervical conization prior to radical hysterectomy in patients with stage IB1 cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) 2009). Methods A multicenter retrospective observational cohort study was conducted including patients from the Surgery in Cervical Cancer Comparing Different Surgical Aproaches in Stage IB1 Cervical Cancer (SUCCOR) database with FIGO 2009 IB1 cervical carcinoma treated with radical hysterectomy between January 1, 2013, and December 31, 2014. We used propensity score matching to minimize the potential allocation biases arising from the retrospective design. Patients who underwent conization but were similar for other measured characteristics were matched 1:1 to patients from the non-cone group using a caliper width

Published
2022

9. Radical hysterectomy in early cervical cancer in Europe: characteristics, outcomes and evaluation of ESGO quality indicators

Author

Boria, Felix Chiva, Luis Zanagnolo, Vanna Querleu, Denis and Martin-Calvo, Nerea Capilna, Mihai Emil Fagotti, Anna and Kucukmetin, Ali Mom, Constantijne Chakalova, Galina and Shamistan, Aliyev Malzoni, Mario Narducci, Fabrice and Arencibia, Octavio Raspagliesi, Francesco Toptas, Tayfun and Cibula, David Kaidarova, Dilyara Meydanli, Mehmet Mutlu and Tavares, Mariana Golub, Dmytro Perrone, Anna Myriam Poka, Robert Tsolakidis, Dimitrios Vujic, Goran Jedryka, Marcin A. and Zusterzeel, Petra L. M. Beltman, Jogchum Jan Goffin, Frederic Haidopoulos, Dimitrios Haller, Herman Jach, Robert and Yezhova, Iryna Berlev, Igor Bernardino, Margarida and Bharathan, Rasiah Lanner, Maximilian Maenpaa, Minna M. and Sukhin, Vladyslav Feron, Jean-Guillaume Fruscio, Robert and Kukk, Kersti Ponce, Jordi Alonso-Espias, Maria Angel Minguez, Jose Vazquez-Vicente, Daniel Manzour, Nabil Jurado, Matias Castellanos, Teresa Chacon, Enrique Luis Alcazar, Juan

Abstract

Introduction Comprehensive updated information on cervical cancer surgical treatment in Europe is scarce. Objective To evaluate baseline characteristics of women with early cervical cancer and to analyze the outcomes of the ESGO quality indicators after radical hysterectomy in the SUCCOR database. Methods The SUCCOR database consisted of 1272 patients who underwent radical hysterectomy for stage IB1 cervical cancer (FIGO 2009) between January 2013 and December 2014. After exclusion criteria, the final sample included 1156 patients. This study first described the clinical, surgical, pathological, and follow-up variables of this population and then analyzed the outcomes (disease-free survival and overall survival) after radical hysterectomy. Surgical-related ESGO quality indicators were assessed and the accomplishment of the stated recommendations was verified. Results The mean age of the patients was 47.1 years (SD 10.8), with a mean body mass index of 25.4 kg/m(2) (SD 4.9). A total of 423 (36.6%) patients had a previous cone biopsy. Tumor size (clinical examination)

Published
2021

10. Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe

Author

Tjalma, Wiebren A., Fiander, Alison, Reich, Olaf, Powell, Ned, Nowakowski, Andrzej M., Kirschner, Benny, Koiss, Robert, OʼLeary, John, Joura, Elmar A., Rosenlund, Mats, Colau, Brigitte, Schledermann, Doris, Kukk, Kersti, Damaskou, Vasileia, Repanti, Maria, Vladareanu, Radu, Kolomiets, Larisa, Savicheva, Alevtina, Shipitsyna, Elena, Ordi, Jaume, Molijn, Anco, Quint, Wim, Raillard, Alice, Rosillon, Dominique, De Souza, Sabrina Collas, Jenkins, David, and Holl, Katsiaryna

Published
2013
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11. SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer

Author

Chiva, L, Zanagnolo, V, Querleu, D, Martin-Calvo, N, Arévalo-Serrano, J, Căpîlna, M, Fagotti, A, Kucukmetin, A, Mom, C, Chakalova, G, Aliyev, S, Malzoni, M, Narducci, F, Arencibia, O, Raspagliesi, F, Toptas, T, Cibula, D, Kaidarova, D, Meydanli, M, Tavares, M, Golub, D, Perrone, A, Poka, R, Tsolakidis, D, Vujić, G, Jedryka, M, Zusterzeel, P, Beltman, J, Goffin, F, Haidopoulos, D, Haller, H, Jach, R, Yezhova, I, Berlev, I, Bernardino, M, Bharathan, R, Lanner, M, Maenpaa, M, Sukhin, V, Feron, J, Fruscio, R, Kukk, K, Ponce, J, Minguez, J, Vázquez-Vicente, D, Castellanos, T, Chacon, E, Alcazar, J, Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Martin-Calvo, Nerea, Arévalo-Serrano, Juan, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Aliyev, Shamistan, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Chacon, Enrique, Alcazar, Juan Luis, Chiva, L, Zanagnolo, V, Querleu, D, Martin-Calvo, N, Arévalo-Serrano, J, Căpîlna, M, Fagotti, A, Kucukmetin, A, Mom, C, Chakalova, G, Aliyev, S, Malzoni, M, Narducci, F, Arencibia, O, Raspagliesi, F, Toptas, T, Cibula, D, Kaidarova, D, Meydanli, M, Tavares, M, Golub, D, Perrone, A, Poka, R, Tsolakidis, D, Vujić, G, Jedryka, M, Zusterzeel, P, Beltman, J, Goffin, F, Haidopoulos, D, Haller, H, Jach, R, Yezhova, I, Berlev, I, Bernardino, M, Bharathan, R, Lanner, M, Maenpaa, M, Sukhin, V, Feron, J, Fruscio, R, Kukk, K, Ponce, J, Minguez, J, Vázquez-Vicente, D, Castellanos, T, Chacon, E, Alcazar, J, Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Martin-Calvo, Nerea, Arévalo-Serrano, Juan, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Aliyev, Shamistan, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Chacon, Enrique, and Alcazar, Juan Luis

Abstract

Background: Minimally invasive surgery in cervical cancer has demonstrated in recent publications worse outcomes than open surgery. The primary objective of the SUCCOR study, a European, multicenter, retrospective, observational cohort study was to evaluate disease-free survival in patients with stage IB1 (FIGO 2009) cervical cancer undergoing open vs minimally invasive radical hysterectomy. As a secondary objective, we aimed to investigate the association between protective surgical maneuvers and the risk of relapse. Methods: We obtained data from 1272 patients that underwent a radical hysterectomy by open or minimally invasive surgery for stage IB1 cervical cancer (FIGO 2009) from January 2013 to December 2014. After applying all the inclusion-exclusion criteria, we used an inverse probability weighting to construct a weighted cohort of 693 patients to compare outcomes (minimally invasive surgery vs open). The first endpoint compared disease-free survival at 4.5 years in both groups. Secondary endpoints compared overall survival among groups and the impact of the use of a uterine manipulator and protective closure of the colpotomy over the tumor in the minimally invasive surgery group. Results: Mean age was 48.3 years (range; 23-83) while the mean BMI was 25.7 kg/m2 (range; 15-49). The risk of recurrence for patients who underwent minimally invasive surgery was twice as high as that in the open surgery group (HR, 2.07; 95% CI, 1.35 to 3.15; P=0.001). Similarly, the risk of death was 2.42-times higher than in the open surgery group (HR, 2.45; 95% CI, 1.30 to 4.60, P=0.005). Patients that underwent minimally invasive surgery using a uterine manipulator had a 2.76-times higher hazard of relapse (HR, 2.76; 95% CI, 1.75 to 4.33; P<0.001) and those without the use of a uterine manipulator had similar disease-free-survival to the open surgery group (HR, 1.58; 95% CI, 0.79 to 3.15; P=0.20). Moreover, patients that underwent minimally invasive surgery with protective va

Published
2020

12. Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe

Author

Tjalma, Wiebren A., Fiander, Alison, Reich, Olaf, Powell, Ned, Nowakowski, Andrzej Marcin, Kirschner, Benny, Koiss, Robert, O'Leary, John, Joura, Elmar A., Rosenlund, Mats, Colau, Brigitte, Schledermann, Doris, Kukk, Kersti, Damaskou, Vasileia, Repanti, Maria, Vladareanu, Radu, Kolomiets, Larisa, Savicheva, Alevtina, Shipitsyna, Elena, Ordi, Jaume, Molijn, Anco, Quint, Wim, Raillard, Alice, Rosillon, Dominique, De Souza, Sabrina Collas, Jenkins, David, Holl, Katsiaryna, The HERACLES/SCALE Study Group, Basta, Antoni, Jach, Robert, Tomaszewska, Romana, and HERACLES/SCALE Study Group

Subjects
Adult, HPV, Cancer Research, medicine.medical_specialty, food.ingredient, Adolescent, cervical cancer, Cross-sectional study, viruses, Uterine Cervical Neoplasms, Cervix Uteri, cervical intraepithelial neoplasia, Alphapapillomavirus, Cervical intraepithelial neoplasia, Young Adult, food, medicine, Humans, CIN, Young adult, human papillomavirus, neoplasms, Aged, Gynecology, Cervical cancer, Aged, 80 and over, business.industry, Papillomavirus Infections, virus diseases, Middle Aged, medicine.disease, Uterine Cervical Dysplasia, female genital diseases and pregnancy complications, Natural history, Europe, Cross-Sectional Studies, Oncology, High Grade Cervical Intraepithelial Neoplasia, DNA, Viral, Histopathology, Female, Human medicine, Neoplasm Grading, business
Abstract

Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected cervical lesions and the potential impact of HPV vaccination on cervical cancer prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled in two parallel cross-sectional studies (108288/108290). Centralised histopathology review and standardised HPV-DNA typing were applied to formalin-fixed paraffin-embedded cervical specimens dated 20012008. The pooled prevalence of individual HPV types was estimated using meta-analytic methods. A total of 3,103 women were diagnosed with HG-CIN and a total of 3,162 with ICC (median ages: 34 and 49 years, respectively), of which 98.5 and 91.8% were HPV-positive, respectively. The most common HPV types in women with HG-CIN were HPV16/33/31 (59.9/10.5/9.0%) and in ICC were HPV16/18/45 (63.3/15.2/5.3%). In squamous cell carcinomas, HPV16/18/33 were most frequent (66.2/10.8/5.3%), and in adenocarcinomas, HPV16/18/45 (54.2/40.4/8.3%). The prevalence of HPV16/18/45 was 1.1/3.5/2.5 times higher in ICC than in HG-CIN. The difference in age at diagnosis between CIN3 and squamous cervical cancer for HPV18 (9 years) was significantly less compared to HPV31/33/other (23/20/17 years), and for HPV45 (1 year) than HPV16/31/33/other (15/23/20/17 years). In Europe, HPV16 predominates in both HG-CIN and ICC, whereas HPV18/45 are associated with a low median age of ICC. HPV18/45 are more frequent in ICC than HG-CIN and associated with a high median age of HG-CIN, with a narrow age interval between HG-CIN and ICC detection. These findings support the need for primary prevention of HPV16/18/45-related cervical lesions.

Published
2011
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13. Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe

Author

Tjalma, Wiebren A, Fiander, Alison, Reich, Olaf, Powell, Ned, Nowakowski, Andrzej M, Kirschner, Benny, Koiss, Robert, O'Leary, John, Joura, Elmar A, Rosenlund, Mats, Colau, Brigitte, Schledermann, Doris, Kukk, Kersti, Damaskou, Vasileia, Repanti, Maria, Vladareanu, Radu, Kolomiets, Larisa, Savicheva, Alevtina, Shipitsyna, Elena, Ordi, Jaume, Molijn, Anco, Quint, Wim, Raillard, Alice, Rosillon, Dominique, De Souza, Sabrina Collas, Jenkins, David, Holl, Katsiaryna, Group, HERACLES/SCALE Study, Tjalma, Wiebren A, Fiander, Alison, Reich, Olaf, Powell, Ned, Nowakowski, Andrzej M, Kirschner, Benny, Koiss, Robert, O'Leary, John, Joura, Elmar A, Rosenlund, Mats, Colau, Brigitte, Schledermann, Doris, Kukk, Kersti, Damaskou, Vasileia, Repanti, Maria, Vladareanu, Radu, Kolomiets, Larisa, Savicheva, Alevtina, Shipitsyna, Elena, Ordi, Jaume, Molijn, Anco, Quint, Wim, Raillard, Alice, Rosillon, Dominique, De Souza, Sabrina Collas, Jenkins, David, Holl, Katsiaryna, and Group, HERACLES/SCALE Study

Published
2013

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