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194 results on '"Kujawska, Małgorzata"'

8. Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson’s Disease: a Comprehensive Review

Author

Zamanian, Mohammad Yasin, primary, Golmohammadi, Maryam, additional, Amin, Rana Sherdil, additional, Bustani, Ghadeer Sabah, additional, Romero-Parra, Rosario Mireya, additional, Zabibah, Rahman S., additional, Oz, Tuba, additional, Jalil, Abduladheem Turki, additional, Soltani, Afsaneh, additional, and Kujawska, Małgorzata, additional

Published
2023
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12. Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects

Author

Rahmani, Mohammad Reza, primary, Zamanian, Mohammad Yassin, additional, Karimvandi, Mahdi Najafiani, additional, Nikbakhtzadeh, Marjan, additional, Zahedi, Elham, additional, Bokov, Dmitry Olegovich, additional, Kujawska, Małgorzata, additional, and Heidari, Mahsa, additional

Published
2023
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13. miR‐221 and Parkinson's disease: A biomarker with therapeutic potential.

Author

Zamanian, Mohammad Yasin, Ivraghi, Mehraveh Sadeghi, Gupta, Reena, Prasad, K. D. V., Alsaab, Hashem O., Hussien, Beneen M., Ahmed, Hazem, Ramadan, Montather F., Golmohammadi, Maryam, Nikbakht, Nikta, Oz, Tuba, and Kujawska, Małgorzata

Subjects
PARKINSON'S disease, MICRORNA, MESSENGER RNA, GENETIC regulation, SUBSTANTIA nigra
Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to various motor and non‐motor symptoms. Several cellular and molecular mechanisms such as alpha‐synuclein (α‐syn) accumulation, mitochondrial dysfunction, oxidative stress and neuroinflammation are involved in the pathogenesis of this disease. MicroRNAs (miRNAs) play important roles in post‐transcriptional gene regulation. They are typically about 21–25 nucleotides in length and are involved in the regulation of gene expression by binding to the messenger RNA (mRNA) molecules. miRNAs like miR‐221 play important roles in various biological processes, including development, cell proliferation, differentiation and apoptosis. miR‐221 promotes neuronal survival against oxidative stress and neurite outgrowth and neuronal differentiation. Additionally, the role of miR‐221 in PD has been investigated in several studies. According to the results of these studies, (1) miR‐221 protects PC12 cells against oxidative stress induced by 6‐hydroxydopamine; (2) miR‐221 prevents Bax/caspase‐3 signalling activation by stopping Bim; (3) miR‐221 has moderate predictive power for PD; (4) miR‐221 directly targets PTEN, and PTEN over‐expression eliminates the protective action of miR‐221 on p‐AKT expression in PC12 cells; and (5) miRNA‐221 controls cell viability and apoptosis by manipulating the Akt signalling pathway in PD. This review study suggested that miR‐221 has the potential to be used as a clinical biomarker for PD diagnosis and stage assignment. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Neuroprotective and anti-inflammatory effects of pioglitazone on Parkinson's disease: A comprehensive narrative review of clinical and experimental findings

Author

Alesaeidi, Samira, primary, Zamanian, Mohammad Yassin, additional, Terefe, Ermias Mergia, additional, Taheri, Niloofar, additional, Kujawska, Małgorzata, additional, Tork, Yekta Jahedi, additional, Abdelbasset, Walid Kamal, additional, Shoukat, Shehla, additional, Catalan Opulencia, Maria Jade, additional, and Heidari, Mahsa, additional

Published
2022
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26. Potential Anti-inflammatory Activity of Brown Propolis Against Brain Ischemia Damage in Mice.

Author

Allahtavakoli, Mohammad, Kamiab, Zahra, Zamanian, Mohammad Yassin, Kujawska, Małgorzata, Boroushaki, Mohammad Taher, Rahmani, Mohammad Reza, Gholamrezapour, Mohammadreza, Pakvojoud, Fatemeh, and Bazmandegan, Gholamreza

Subjects
CEREBRAL ischemia, BRAIN damage, PROPOLIS, ANTI-inflammatory agents, CEREBRAL edema, ELLAGIC acid
Abstract

Background: Inflammation plays a major part in brain ischemia. Propolis is a polyphenol-rich hive product with a set of pharmaceutical properties. Objectives: This research aims to investigate the impact of water extracts of brown propolis (WEPs) on stroke outcomes and inflammatory responses in a rat model of permanent middle cerebral artery occlusion (MCAO). Materials & Methods: This experimental study was conducted in Rafsanjan, Iran, in 2017. WEPs were experimentally prepared from two regions in Iran. Gas chromatography-mass spectrometry and Folin-Ciocalteu assays were used to determine chemical portrayal and the total polyphenol content, respectively. A total of 66 male adult mice were divided randomly into the surgical sham, control (vehicle-treated), and four WEPs-treated animal groups. WEPs-treated groups received doses of 100 and 200 (mg/kg, IP) four times, and their behavioral tests, brain edema, infarct volume, and tumor necrosis factor-alpha (TNF-a) level were evaluated. Results: The samples were not significantly different in terms of the concentration of the total polyphenol content. Compared to the control, WEPs led to a substantial decrease in the TNF-a level (P<0.05) as well as a subsequent reduction in the brain edema and infarct volume (P<0.001) in all treatment groups. Furthermore, there was a significant improvement in neurological deficits and sensory-motor impairments level (P<0.05). Conclusion: According to the study findings, WEPs reduce brain ischemia damage, perhaps by exerting a neuroprotective effect on stroke-induced neuroinflammatory responses. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Calcium dobesilate protects against d‐galactose‐induced hepatic and renal dysfunction, oxidative stress, and pathological damage

Author

Hakimizadeh, Elham, primary, Zamanian, Mohammad Yassin, additional, Damankhorshid, Morteza, additional, Giménez‐Llort, Lydia, additional, Sciorati, Clara, additional, Nikbakhtzadeh, Marjan, additional, Moradbeygi, Khadijeh, additional, Kujawska, Małgorzata, additional, Kaeidi, Ayat, additional, Taghipour, Zahra, additional, and Fatemi, Iman, additional

Published
2022
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29. How to optimize the effectiveness and safety of Parkinson's disease therapy? : a systematic review of drugs interactions with food and dietary supplements

Author

Kujawska Małgorzata, Paśko Paweł, and Wiesner Agnieszka

Subjects
Parkinson's disease, Monoamine Oxidase Inhibitors, Pimavanserin, Pharmacology, Antiparkinson Agents, Levodopa, chemistry.chemical_compound, Cabergoline, Selegiline, medicine, Humans, Pharmacology (medical), Monoamine Oxidase, Safinamide, Rasagiline, Tolcapone, business.industry, Parkinson Disease, General Medicine, medicine.disease, Psychiatry and Mental health, Ropinirole, Neurology, chemistry, Dietary Supplements, Neurology (clinical), business, medicine.drug
Abstract

Background: Despite increasing worldwide incidence of Parkinson’s disease, the therapy is still suboptimal due to the diversified clinical manifestations, lack of sufficient treatment, the poor adherence in advanced patients, and varied response. Proper intake of medications regarding food and managing drug-food interactions may optimize Parkinson’s disease treatment. Objectives: We investigated potential effects that food, beverages, and dietary supplements may have on the pharmacokinetics and pharmacodynamics of drugs used by parkinsonian patients; identified the most probable interactions; and shaped recommendations for the optimal intake of drugs regarding food. Methods: We performed a systematic review in adherence to PRISMA guidelines, and included a total of 81 studies in the qualitative synthesis. Results and Conclusions: We found evidence for levodopa positive interaction with coffee, fiber and vitamin C, as well as for the potential beneficial impact of low-fat and protein redistribution diet. Contrastingly, high-protein diet and ferrous sulfate supplements can negatively affect levodopa pharmacokinetics and effectiveness. For other drugs, the data of food impact are scarce. Based on the available limited evidence, all dopamine agonists (bromocriptine, cabergoline, ropinirole), tolcapone, rasagiline, selegiline in tablets, safinamide, amantadine and pimavanserin can be taken with or without a meal. Opicapone and orally disintegrating selegiline tablets should be administered on an empty stomach. Of monoamine oxidase B inhibitors, safinamide is the least susceptible for interaction with the tyramine-rich food, whereas selegiline and rasagiline may lose selectivity to monoamine oxidase B when administered in supratherapeutic doses. The level of presented evidence is low due to the poor studies design, their insufficient actuality, and missing data.

Published
2022

37. Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

Author

Hakimizadeh, Elham, Zamanian, Mohammad, Gimenez-Llort, Lydia, Sciorati, Clara, Nikbakhtzadeh, Marjan, Kujawska, Małgorzata, Kaeidi, Ayat, Hassanshahi, Jalal, Fatemi, Iman, and Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal

Subjects
0301 basic medicine, medicine.medical_specialty, Aging, Antioxidant, mice, Physiology, medicine.medical_treatment, Clinical Biochemistry, D-galactose, Calcium dobesilate, antioxidant activity, Doxium, RM1-950, medicine.disease_cause, Biochemistry, Article, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Antioxidant activity, Internal medicine, medicine, oxidative stress, Molecular Biology, chemistry.chemical_classification, Reactive oxygen species, biology, business.industry, Glutathione peroxidase, aging, Cell Biology, Malondialdehyde, 030104 developmental biology, Endocrinology, calcium dobesilate, chemistry, Catalase, Oxidative stress, biology.protein, Therapeutics. Pharmacology, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Funding: This work was supported by grant no. 97175 from the Vice-Chancellor for Research and Technology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. It also received support from Memorial Mercè Llort Sender 2021/80/092421.1. The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative stress-linked cognitive disorders in physiological aging. Calcium dobesilate (CaD, Doxium®) is an established vasoactive and angioprotective drug commonly used for the clinical treatment of diabetic retinopathy and chronic venous insufficiency. It has antioxidant properties and controls vascular permeability. In the current study, we evaluated the protective effects of CaD (50 and 100 mg/kg/day p.o.) in male mice treated with D-gal (500 mg/kg/day p.o.) for six weeks. Results demonstrated that body weight loss, anxiety-like and cognitive impairments of D-gal-treated animals were reversed by CaD administration as evaluated by the measurement of mice performance in elevated plus-maze, Y-maze, and shuttle box tests. CaD treatment also inhibited the oxidative stress in aging mouse brains by decreasing malondialdehyde (MDA) levels and increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) enzyme activities. These results could open new perspectives for the clinical use of CaD in treating and preventing cognitive impairment in older people.

Published
2021

39. Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects

Author

Zamanian, Mohammad Yassin, Karimvandi, Mahdi Najafiani, Nikbakhtzadeh, Marjan, Zahedi, Elham, Bokov, Dmitry Olegovich, Kujawska, Małgorzata, Heidari, Mahsa, and Rahmani, Mohammad Reza

Abstract

Modafinil (MOD, 2‐diphenyl‐methyl‐sulphinil‐2‐acetamide) is a stimulant-like medicine used to treat narcolepsy. Off-label uses include improving cognitive ability in the course of other diseases. This review aims to discuss findings demonstrating the memory and learningenhancing activity of MOD in experimental and clinical studies. We included behavioral evaluations alongside the effects of MOD at the cellular and molecular level. MOD in different animal disease models exerted beneficial effects on induced memory and learning impairment, which in some cases were accompanied by modulation of neurotransmitter pathways or neuroplastic capabilities, reducing oxidative stress, or expression of synaptic proteins. Individuals treated with MOD showed improved memory and learning skills in different conditions. These effects were associated with regulating brain activity in some participants, confirmed by functional magnetic resonance imaging. Presented herein, data support the use of MOD in treating memory and learning deficits in various disease conditions.

Published
2023
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46. Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

Author

Kujawska, Małgorzata, primary, Jourdes, Michael, additional, Kurpik, Monika, additional, Szulc, Michał, additional, Szaefer, Hanna, additional, Chmielarz, Piotr, additional, Kreiner, Grzegorz, additional, Krajka-Kuźniak, Violetta, additional, Mikołajczak, Przemyslaw Łukasz, additional, Teissedre, Pierre-Louis, additional, and Jodynis-Liebert, Jadwiga, additional

Published
2019
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48. Selective sorption of diethyl phthalate on pH-responsive, molecularly imprinted polymeric adsorbents.

Author

Wolska, Joanna, Kujawska, Małgorzata, and Cyganowski, Piotr

Subjects
*DIETHYL phthalate, *METHYL methacrylate, *SORPTION, *ACRYLIC acid, *PHTHALATE esters, *IMPRINTED polymers, *ETHYLENE glycol, *PHTHALIC acid
Abstract

A novel synthetic route for preparation of pH-responsive molecularly imprinted adsorbents for separation of diethyl phthalate (DEP) is proposed. Polymers were synthesized using acrylic acid (AAc) and methyl methacrylate (MMA) crosslinked using ethylene glycol dimethacrylate (EGDMA) or divinylbenzene (DVB). The carried out tests revealed the pH-driven recognition of synthesized sorbents toward DEP. It was found that sorbents derived from mixture of 30% AAc:MMA (1:1) and 70 wt.% of DVB in the presence of 7 wt.% of template were the best. The DEP sorption took the highest value (85 mg g−1) at pH = 5, while desorption with extent of 92% was the most efficient at pH = 8. [ABSTRACT FROM AUTHOR]

Published
2020
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