Author: "Kuiper LM" - Searchworks@Jio Institute Digital Library Search Results

12 results on '"Kuiper LM"'

1. Past or Present; Which Exposures Predict Metabolomic Aging Better?:The Doetinchem Cohort Study

Author: Smit, AP, Herber, GCM, Kuiper, LM, Loef, B, Picavet, HSJ, Verschuren, WMM, Smit, AP, Herber, GCM, Kuiper, LM, Loef, B, Picavet, HSJ, and Verschuren, WMM
Abstract: People age differently. Differences in aging might be reflected by metabolites, also known as metabolomic aging. Predicting metabolomic aging is of interest in public health research. However, the added value of longitudinal over cross-sectional predictors of metabolomic aging is unknown. We studied exposome-related exposures as potential predictors of metabolomic aging, both cross-sectionally and longitudinally in men and women. We used data from 4 459 participants, aged 36–75 of Round 4 (2003–2008) of the long-running Doetinchem Cohort Study (DCS). Metabolomic age was calculated with the MetaboHealth algorithm. Cross-sectional exposures were demographic, biological, lifestyle, and environmental at Round 4. Longitudinal exposures were based on the average exposure over 15 years (Round 1 [1987–1991] to 4), and trend in these exposure over time. Random Forest was performed to identify model performance and important predictors. Prediction performances were similar for cross-sectional and longitudinal exposures in both men (R2 6.8 and 5.8, respectively) and women (R2 14.8 and 14.4, respectively). Biological and diet exposures were most predictive for metabolomic aging in both men and women. Other important predictors were smoking behavior for men and contraceptive use and menopausal status for women. Taking into account history of exposure levels (longitudinal) had no added value over cross-sectionally measured exposures in predicting metabolomic aging in the current study. However, the prediction performances of both models were rather low. The most important predictors for metabolomic aging were from the biological and lifestyle domain and differed slightly between men and women.
Published: 2024

2. The LOFT mission concept: a status update

Author: Feroci, M, Bozzo, E, Brandt, S, Hernanz, M, Van Der Klis, M, Liu, L, Orleanski, P, Pohl, M, Santangelo, A, Schanne, S, Stella, L, Takahashi, T, Tamura, H, Watts, A, Wilms, J, Zane, S, Zhang, S, Bhattacharyya, S, Agudo, I, Ahangarianabhari, M, Albertus, C, Alford, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Artigues, B, Atteia, J, Azzarello, P, Bakala, P, Ballantyne, Dr, Baldazzi, G, Baldo, M, Balman, S, Barbera, M, Van Baren, C, Barret, D, Baykal, A, Begelman, M, Behar, E, Behar, O, Belloni, T, Bellutti, P, Bernardini, F, Bertuccio, G, Bianchi, S, Bianchini, A, Binko, P, Blay, P, Bocchino, F, Bode, M, Bodin, P, Bombaci, I, Bonnet Bidaud, J, Borghi, G, Boutloukos, S, Bouyjou, F, Bradley, L, Braga, J, Briggs, Ms, Brown, E, Buballa, M, Bucciantini, N, Burderi, L, Burgay, M, Bursa, M, Budtz-Jorgensen, C, Cackett, E, Cadoux, Fr, Cais, P, Caliandro, Ga, Campana, R, Campana, S, Cao, X, Capitanio, F, Casares, J, Casella, P, Castro-Tirado, Aj, Cavazzuti, E, Cavechi, Y, Celestin, S, Cerda-Duran, P, Chakrabarty, D, Chamel, N, Chateau, F, Chen, C, Chen, Y, Chenevez, J, Chernyakova, M, Coker, J, Cole, R, Collura, A, Coriat, M, Cornelisse, R, Costamante, L, Cros, A, Cui, W, Cumming, A, Cusumano, G, Czerny, B, D'Ai, A, D'Ammando, F, D'Elia, V, Dai, Z, Del Monte, E, De Luca, A, De Martino, D, Dercksen, Jpc, De Pasquale, M, De Rosa, A, Del Santo, M, Di Cosimo, S, Degenaar, N, Den Herder, Jw, Diebold, S, Di Salvo, T, Dong, Y, Donnarumma, I, Doroshenko, V, Doyle, G, Drake, Sa, Durant, M, Emmanoulopoulos, D, Enoto, T, Erkut, Mh, Esposito, P, Evangelista, Y, Fabian, A, Falanga, M, Favre, Y, Feldman, C, Fender, R, Feng, H, Ferrari, V, Ferrigno, C, Ficorella, F, Finger, M, Finger, Mh, Fraser, Gw, Frericks, M, Fullekrug, M, Fuschino, F, Gabler, M, Galloway, Dk, Galvez Sanchez, Jl, Gandhi, P, Gao, Z, Garcia-Berro, E, Gendre, B, Gevin, O, Gezari, S, Giles, Ab, Gilfanov, M, Giommi, P, Giovannini, G, Giroletti, M, Gogus, E, Goldwurm, A, Goluchova, K, Gotz, D, Gou, L, Gouiffes, C, Grandi, P, Grassi, M, Greiner, J, Grinberg, V, Groot, P, Gschwender, M, Gualtieri, L, Guedel, M, Guidorzi, C, Guy, L, Haas, D, Haensel, P, Hailey, M, Hamuguchi, K, Hansen, F, Hartmann, Dh, Haswell, Ca, Hebeler, K, Heger, A, Hempel, M, Hermsen, W, Homan, J, Hornstrup, A, Hudec, R, Huovelin, J, Huppenkothen, D, Inam, Sc, Ingram, A, In'Tzand, Jjm, Israel, G, Iwasawa, K, Izzo, L, Jacobs, Hm, Jetter, F, Johannsen, T, Jenke, Pa, Jonker, P, Jose, J, Kaaret, P, Kalamkar, M, Kalemci, E, Kanbach, G, Karas, V, Karelin, D, Kataria, D, Keek, L, Kennedy, T, Klochkov, D, Kluzniak, W, Koerding, E, Kokkotas, K, Komossa, S, Korpela, S, Kouveliotou, C, Kowalski, Af, Kreykenbohm, I, Kuiper, Lm, Kunneriath, D, Kurkela, A, Kuvvetli, I, La Franca, F, Labanti, C, Lai, D, Lamb, Fk, Lachaud, C, Laubert, Pp, Lebrun, F, Li, X, Liang, E, Limousin, O, Lin, D, Linares, M, Linder, D, Lodato, G, Longo, F, Lu, F, Lund, N, Maccarone, Tj, Macera, D, Maestre, S, Mahmoodifar, S, Maier, D, Malcovati, P, Malzac, J, Malone, C, Mandel, I, Mangano, V, Manousakis, A, Marelli, M, Margueron, J, Marisaldi, M, Markoff, Sb, Markowitz, A, Marinucci, A, Martindale, A, Martinez, G, Mchardy, Im, Medina-Tanco, G, Mehdipour, M, Melatos, A, Mendez, M, Mereghetti, S, Migliari, S, Mignani, R, Michalska, M, Mihara, T, Miller, Mc, Miller, Jm, Mineo, T, Miniutti, G, Morsink, S, Motch, C, Motta, S, Mouchet, M, Mouret, G, Mulacova, J, Muleri, F, Munoz-Darias, T, Negueruela, I, Neilsen, J, Neubert, T, Norton, Aj, Nowak, M, Nucita, A, O'Brien, P, Oertel, M, Olsen, Peh, Orienti, M, Orio, M, Orlandini, M, Osborne, Jp, Osten, R, Ozel, F, Pacciani, L, Paerels, F, Paltani, S, Paolillo, M, Papadakis, I, Papitto, A, Paragi, Z, Paredes, Jm, Patruno, A, Paul, B, Pederiva, F, Perinati, E, Pellizzoni, A, Penacchioni, Av, Peretz, U, Perez, Ma, Perez-Torres, M, Peterson, Bm, Petracek, V, Picciotto, A, Piemonte, C, Pittori, C, Pons, J, Portell, J, Possenti, A, Postnov, K, Poutanen, J, Prakash, M, Prandoni, I, Le Provost, H, Psaltis, D, Pye, J, Qu, J, Rambaud, D, Ramon, P, Ramsay, G, Rapisarda, M, Rachevski, A, Rashevskaya, I, Ray, Ps, Rea, N, Reddy, S, Reig, P, Reina Aranda, M, Remillard, R, Reynolds, C, Rezzolla, L, Ribo, M, De La Rie, R, Riggio, A, Rios, A, Rischke, Dh, Rodriguez-Gil, P, Rodriguez, J, Rohlfs, R, Romano, P, Rossi, Emr, Rozanska, A, Rousseau, A, Rudak, B, Russell, Dm, Ryde, F, Sabau-Graziati, L, Sakamoto, T, Sala, G, Salvaterra, R, Salvetti, D, Sanna, A, Sandberg, J, Savolainen, T, Scaringi, S, Schaffner-Bielich, J, Schatz, H, Schee, J, Schmid, C, Serino, M, Shakura, N, Shore, S, Schnittman, Jd, Schneider, R, Schwenk, A, Schwope, Ad, Sedrakian, A, Seyler, J, Shearer, A, Slowikowska, A, Sims, M, Smith, A, Smith, Dm, Smith, Pj, Sobolewska, M, Sochora, V, Soffitta, P, Soleri, P, Song, L, Spencer, A, Stamerra, A, Stappers, B, Staubert, R, Steiner, Aw, Stergioulas, N, Stevens, Al, Stratta, G, Strohmayer, Te, Stuchlik, Z, Suchy, S, Suleimanov, V, Tamburini, F, Tauris, T, Tavecchio, F, Tenzer, C, Thielemann, Fk, Tiengo, A, Tolos, L, Tombesi, F, Tomsick, J, Torok, G, Torrejon, Jm, Torres, Df, Torresi, E, Tramacere, A, Traulsen, I, Trois, A, Turolla, R, Turriziani, S, Typel, S, Uter, P, Uttley, P, Vacchi, A, Varniere, P, Vaughan, S, Vercellone, S, Vietri, M, Vincent, Fh, Vrba, V, Walton, D, Wang, J, Wang, Z, Watanabe, S, Wawrzaszek, R, Webb, N, Weinberg, N, Wende, H, Wheatley, P, Wijers, R, Wijnands, R, Wille, M, Wilson-Hodge, Ca, Winter, B, Walk, Sj, Wood, K, Woosley, Se, Wu, X, Xiao, L, Xu, R, Yu, W, Yuan, F, Yuan, W, Yuan, Y, Zampa, G, Zampa, N, Zampieri, L, Zdunik, L, Zdziarski, A, Zech, A, Zhang, B, Zhang, C, Zingale, M, Zorzi, N, Zwart, F, High Energy Astrophys. & Astropart. Phys (API, FNWI), ISDC Data Centre for Astrophysics, Université de Genève = University of Geneva (UNIGE), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Rutgers, The State University of New Jersey [New Brunswick] (RU), Rutgers University System (Rutgers), Institut für Astronomie und Astrophysik [Tübingen] (IAAT), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze e Tecnologie Chimiche, Università degli Studi di Roma Tor Vergata [Roma], Graduate School of the Natural Science and Technology [Kanazawa], Kanazawa University (KU), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Tampere University of Technology [Tampere] (TUT), University of Maryland [College Park], University of Maryland System, Department of Biological Sciences [Mississippi], University of Southern Mississippi (USM), School of Physics and Astronomy [Southampton], University of Southampton, Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano (IASF-MI), Istituto Nazionale di Astrofisica (INAF), Università di Roma La Sapienza, Università di Roma Tor Vergata, Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Laboratoire d'Astrophysique de l'Observatoire Midi-Pyrénées (LATT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Swedish Institute of Space Physics [Uppsala] (IRF), INAF - Osservatorio Astronomico di Brera (OAB), Department of Computer Sciences [Scheffield], University of Sheffield [Sheffield], Colgate University, Bibliothèque nationale de France (BnF), Istituto di Astrofisica Spaziale e Fisica cosmica - Palermo (IASF-Pa), ARC Centre of Excellence for Environmental Decisions (ARC CEED), The University of Western Australia (UWA)-Australian National University (ANU)-University of Queensland [Brisbane]-Royal Melbourne Institute of Technology University (RMIT University)-School of BioSciences [Melbourne], Faculty of Science [Melbourne], University of Melbourne-University of Melbourne-Faculty of Science [Melbourne], University of Melbourne-University of Melbourne, ARC Centre of Excellence for Coral Reef Studies (CoralCoE), James Cook University (JCU), Lund University [Lund], Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de synthèse organique (DCSO), École polytechnique (X)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Alabama at Birmingham [ Birmingham] (UAB), INAF - Osservatorio Astronomico di Cagliari (OAC), ELECTRONIQUE 2016, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), School of Geosciences, Monash University [Clayton], Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université libre de Bruxelles (ULB), National Oceanography Centre [Southampton] (NOC), Dublin Institute for Advanced Studies (DIAS), Dublin City University [Dublin] (DCU), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Institut Parisien de Chimie Moléculaire (IPCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chinese Academy of Sciences [Beijing] (CAS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), China Information Technology Security Evaluation Center (CNITSEC), Department of Applied Mathematics and Computer Science [Lyngby] (DTU Compute), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), PCAS, Anton Pannekoek Institute for Astronomy, Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), International Space Science Institute [Bern] (ISSI), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CALVIN research group [Edinburgh], Institute of Perception, Action and Behaviour (IPAB), University of Edinburgh-University of Edinburgh, Department of Electronics and Electrical Engineering [Bath], University of Bath [Bath], United States Geological Survey [Reston] (USGS), Sr. PLM Consultant, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Dept Ind Engn & Informat Techonolgy, Università degli studi di Trieste = University of Trieste, Max-Planck-Institut für Extraterrestrische Physik (MPE), MIT Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology (MIT), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Wisconsin Regional Primate Research Center, University of Wisconsin-Madison, SRON Netherlands Institute for Space Research (SRON), Opole University of Technology, University of Technology (Opole), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Astrophysics [Nijmegen], Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud University [Nijmegen]-Radboud University [Nijmegen], Radboud University [Nijmegen], NASA Goddard Space Flight Center (GSFC), Dept Fis Aplicada, Universidad de Granada = University of Granada (UGR), Victoria University [Melbourne], The Hong Kong Polytechnic University [Hong Kong] (POLYU), Chinese Academy of Sciences [Changchun Branch] (CAS), Department of Physics, Chemistry and Biology [Linköping] (IFM), Linköping University (LIU), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Erlangen Centre for Astroparticle Physics (ECAP), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Centre de recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institute of Astronomy, University of Zielona Góra, Department of Electronics and Computer Systems, Takushoku University, Instituto Nacional de Pesquisas da Amazônia (INPA), Università degli studi di Catania = University of Catania (Unict), Centre d'Ecologie et des Sciences de la COnservation (CESCO), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de Physico-Chimie de l'Atmosphère (LPCA), Université du Littoral Côte d'Opale (ULCO)-Centre National de la Recherche Scientifique (CNRS), HEPL, Solar Physics, Stanford University, Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Space Telescope Science Institute (STSci), Dipartimento di Scienze Fisiche [Naples], University of Naples Federico II = Università degli studi di Napoli Federico II, Columbia University [New York], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Department of Anthropology [University of Arkansas], University of Arkansas [Fayetteville], Hu county ventre for disease control and prevention of Shaanxi province, Istituto Nazionale di Fisica Nucleare, Sezione di Trieste (INFN, Sezione di Trieste), Istituto Nazionale di Fisica Nucleare (INFN), Institut Jean le Rond d'Alembert (DALEMBERT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut de Ciencies de l'Espai [Barcelona] (ICE-CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Reading (UOR), Departamento de Matemática Aplicada, Universidade de Santiago de Compostela [Spain] (USC ), Osservatorio Astrofisico di Catania, Équipe Robotique et InteractionS (LAAS-RIS), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Centro Euro-Mediterraneo per i Cambiamenti Climatici [Bologna] (CMCC), Institut für Theoretische Physik, Universität Heidelberg [Heidelberg] = Heidelberg University, Augsburg Hospital, Leibniz-Institut für Astrophysik Potsdam (AIP), Daimler Chrysler AG (Daimler), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Montserrat Volcano Observatory (MVO), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Jodrell Bank Centre for Astrophysics, University of Manchester [Manchester], FICLIT, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Max-Planck-Institut für Radioastronomie (MPIFR), Argelander-Institut für Astronomie (AlfA), Rheinische Friedrich-Wilhelms-Universität Bonn, Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Christian-Albrechts-Universität zu Kiel (CAU), Dipartimento di Fisica e Astronomia 'Galileo Galilei', Università degli Studi di Padova = University of Padua (Unipd), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Cahill Center for Astronomy and Astrophysics, California Institute of Technology (CALTECH), Xinjiang Astronomical Observatory, Mitsubishi Electric Research Laboratories (MERL), Mitsubishi Research Institute, Inc., School of Urban and Regional Planning, University of Southern California (USC), National University of Defense Technology [China], Princeton University, Department of Microtechnology and Nanoscience (MC2), Chalmers University of Technology [Gothenburg, Sweden], Feroci, M., Bozzo, E., Brandt, S., Hernanz, M., van der Klis, M., Liu, L., Orleanski, P., Pohl, M., Santangelo, A., Schanne, S., Stella, L., Takahashi, T., Tamura, H., Watts, A., Wilms, J., Zane, S., Zhang, S., Bhattacharyya, S., Agudo, I., Ahangarianabhari, M., Albertus, C., Alford, M., Alpar, A., Altamirano, D., Alvarez, L., Amati, L., Amoros, C., Andersson, N., Antonelli, A., Argan, A., Artigue, R., Artigues, B., Atteia, J., Azzarello, P., Bakala, P., Ballantyne, D., Baldazzi, G., Baldo, M., Balman, S., Barbera, M., van Baren, C., Barret, D., Baykal, A., Begelman, M., Behar, E., Behar, O., Belloni, T., Bernardini, F., Bertuccio, G., Bianchi, S., Bianchini, A., Binko, P., Blay, P., Bocchino, F., Bode, M., Bodin, P., Bombaci, I., Bonnet Bidaud, J., Boutloukos, S., Bouyjou, F., Bradley, L., Braga, J., Briggs, M., Brown, E., Buballa, M., Bucciantini, N., Burderi, L., Burgay, M., Bursa, M., Budtz Jørgensen, C., Cackett, E., Cadoux, F., Cais, P., Caliandro, G., Campana, R., Campana, S., Cao, X., Capitanio, F., Casares, J., Casella, P., Castro Tirado, A., Cavazzuti, E., Cavechi, Y., Celestin, S., Cerda Duran, P., Chakrabarty, D., Chamel, N., Château, F., Chen, C., Chen, Y., Chenevez, J., Chernyakova, M., Coker, J., Cole, R., Collura, A., Coriat, M., Cornelisse, R., Costamante, L., Cros, A., Cui, W., Cumming, A., Cusumano, G., Czerny, B., D'Aì, A., D'Ammando, F., D'Elia, V., Dai, Z., Del Monte, E., De Luca, A., De Martino, D., Dercksen, J., De Pasquale, M., De Rosa, A., Del Santo, M., Di Cosimo, S., Degenaar, N., den Herder, J., Diebold, S., DI SALVO, T., Dong, Y., Donnarumma, I., Doroshenko, V., Doyle, G., Drake, S., Durant, M., Emmanoulopoulos, D., Enoto, T., Erkut, M., Esposito, P., Evangelista, Y., Fabian, A., Falanga, M., Favre, Y., Feldman, C., Fender, R., Feng, H., Ferrari, V., Ferrigno, C., Finger, M., Fraser, G., Frericks, M., Fullekrug, M., Fuschino, F., Gabler, M., Galloway, D., Gálvez Sanchez, J., Gandhi, P., Gao, Z., Garcia Berro, E., Gendre, B., Gevin, O., Gezari, S., Giles, A., Gilfanov, M., Giommi, P., Giovannini, G., Giroletti, M., Gogus, E., Goldwurm, A., Goluchová, K., Götz, D., Gou, L., Gouiffes, C., Grandi, P., Grassi, M., Greiner, J., Grinberg, V., Groot, P., Gschwender, M., Gualtieri, L., Guedel, M., Guidorzi, C., Guy, L., Haas, D., Haensel, P., Hailey, M., Hamuguchi, K., Hansen, F., Hartmann, D., Haswell, C., Hebeler, K., Heger, A., Hempel, M., Hermsen, W., Homan, J., Hornstrup, A., Hudec, R., Huovelin, J., Huppenkothen, D., Inam, S., Ingram, A., In't Zand, J., Israel, G., Iwasawa, K., Izzo, L., Jacobs, H., Jetter, F., Johannsen, T., Jenke, P., Jonker, P., Josè, J., Kaaret, P., Kalamkar, K., Kalemci, E., Kanbach, G., Karas, V., Karelin, D., Kataria, D., Keek, L., Kennedy, T., Klochkov, D., Kluzniak, W., Koerding, E., Kokkotas, K., Komossa, S., Korpela, S., Kouveliotou, C., Kowalski, A., Kreykenbohm, I., Kuiper, L., Kunneriath, D., Kurkela, A., Kuvvetli, I., La Franca, F., Labanti, C., Lai, D., Lamb, F., Lachaud, C., Laubert, P., Lebrun, F., Li, X., Liang, E., Limousin, O., Lin, D., Linares, M., Linder, D., Lodato, G., Longo, F., Lu, F., Lund, N., Maccarone, T., Macera, D., Maestre, S., Mahmoodifar, S., Maier, D., Malcovati, P., Malzac, J., Malone, C., Mandel, I., Mangano, V., Manousakis, A., Marelli, M., Margueron, J., Marisaldi, M., Markoff, S., Markowitz, A., Marinucci, A., Martindale, A., Martínez, G., Mchardy, I., Medina Tanco, G., Mehdipour, M., Melatos, A., Mendez, M., Mereghetti, S., Migliari, S., Mignani, R., Michalska, M., Mihara, T., Miller, M., Miller, J., Mineo, T., Miniutti, G., Morsink, S., Motch, C., Motta, S., Mouchet, M., Mouret, G., Mulačová, J., Muleri, F., Muñoz Darias, T., Negueruela, I., Neilsen, J., Neubert, T., Norton, A., Nowak, M., Nucita, A., O'Brien, P., Oertel, M., Olsen, P., Orienti, M., Orio, M., Orlandini, M., Osborne, J., Osten, R., Ozel, F., Pacciani, L., Paerels, F., Paltani, S., Paolillo, M., Papadakis, I., Papitto, A., Paragi, Z., Paredes, J., Patruno, A., Paul, B., Pederiva, F., Perinati, E., Pellizzoni, A., Penacchioni, A., Peretz, U., Perez, M., Perez Torres, M., Peterson, B., Petracek, V., Pittori, C., Pons, J., Portell, J., Possenti, A., Postnov, K., Poutanen, J., Prakash, M., Prandoni, I., Le Provost, H., Psaltis, D., Pye, J., Qu, J., Rambaud, D., Ramon, P., Ramsay, G., Rapisarda, M., Rashevski, A., Rashevskaya, I., Ray, P., Rea, N., Reddy, S., Reig, P., Reina Aranda, M., Remillard, R., Reynolds, C., Rezzolla, L., Ribo, M., de la Rie, R., Riggio, A., Rios, A., Rischke, D., Rodríguez Gil, P., Rodriguez, J., Rohlfs, R., Romano, P., Rossi, E., Rozanska, A., Rousseau, A., Rudak, B., Russell, D., Ryde, F., Sabau Graziati, L., Sakamoto, T., Sala, G., Salvaterra, R., Salvetti, D., Sanna, A., Sandberg, J., Savolainen, T., Scaringi, S., Schaffner Bielich, J., Schatz, H., Schee, J., Schmid, C., Serino, M., Shakura, N., Shore, S., Schnittman, J., Schneider, R., Schwenk, A., Schwope, A., Sedrakian, A., Seyler, J., Shearer, A., Slowikowska, A., Sims, M., Smith, A., Smith, D., Smith, P., Sobolewska, M., Sochora, V., Soffitta, P., Soleri, P., Song, L., Spencer, A., Stamerra, A., Stappers, B., Staubert, R., Steiner, A., Stergioulas, N., Stevens, A., Stratta, G., Strohmayer, T., Stuchlik, Z., Suchy, S., Suleimanov, V., Tamburini, F., Tauris, T., Tavecchio, F., Tenzer, C., Thielemann, F., Tiengo, A., Tolos, L., Tombesi, F., Tomsick, J., Torok, G., Torrejon, J., Torres, D., Torresi, E., Tramacere, A., Traulsen, I., Trois, A., Turolla, R., Turriziani, S., Typel, S., Uter, P., Uttley, P., Vacchi, A., Varniere, P., Vaughan, S., Vercellone, S., Vietri, M., Vincent, F., Vrba, V., Walton, D., Wang, J., Wang, Z., Watanabe, S., Wawrzaszek, R., Webb, N., Weinberg, N., Wende, H., Wheatley, P., Wijers, R., Wijnands, R., Wille, M., Wilson Hodge, C., Winter, B., Walk, S., Wood, K., Woosley, S., Wu, X., Xu, R., Yu, W., Yuan, F., Yuan, W., Yuan, Y., Zampa, G., Zampa, N., Zampieri, L., Zdunik, L., Zdziarski, A., Zech, A., Zhang, B., Zhang, C., Zingale, M., Zwart, F., University of Geneva [Switzerland], Eberhard Karls Universität Tübingen, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Graduate School of the Natural Science and Technology, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), School of BioSciences [Melbourne], University of Melbourne-University of Melbourne-Royal Melbourne Institute of Technology University (RMIT University)-University of Queensland [Brisbane]-Australian National University (ANU)-The University of Western Australia (UWA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Centre National d’Études Spatiales [Paris] (CNES), Université Libre de Bruxelles [Bruxelles] (ULB), Dublin City University, Dublin 9, Ireland, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), China Information Technology Security Evaluation Center, Technical University of Denmark [Lyngby] (DTU), Université Grenoble Alpes (UGA), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Trieste, Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Intégrative de la Cellule (I2BC), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Università degli Studi di Roma 'La Sapienza' [Rome], Radboud university [Nijmegen]-Radboud university [Nijmegen], Radboud university [Nijmegen], Universidad de Granada (UGR), Centre National de la Recherche Scientifique (CNRS), Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Catania [Catania], Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS)-Université du Littoral Côte d'Opale, Stanford University [Stanford], Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Università degli studi di Napoli Federico II, IFP Energies nouvelles (IFPEN), National Institute for Nuclear Physics (INFN), Institut Jean Le Rond d'Alembert (DALEMBERT), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J), Ingénierie des Matériaux Polymères (IMP), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Centro Euro-Mediterraneo per i Cambiamenti Climatici (CMCC), Universität Heidelberg [Heidelberg], Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Università di Bologna [Bologna] (UNIBO), University of California [Berkeley], University of California-University of California, Universita degli Studi di Padova, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Chalmers University of Technology [Göteborg], Astronomy, Jan-Willem A. den Herder, Shouleh Nikzad, Kazuhiro Nakazawa, Van Der Klis, M., Liu, L. -P., Zhang, S. -N., Atteia, J. -L., Ballantyne, D. R., Van Baren, C., Bellutti, P., Bonnet Bidaud, J. -M., Borghi, G., Briggs, M. S., Budtz-Jorgensen, C., Cadoux, F. R., Caliandro, G. A., Castro-Tirado, A. J., Cerda-Duran, P., Chateau, F., D'Ai, A., Dercksen, J. P. C., Den Herder, J. W., Di Salvo, T., Drake, S. A., Erkut, M. H., Ficorella, F., Finger, M. H., Fraser, G. W., Galloway, D. K., Galvez Sanchez, J. L., Garcia-Berro, E., Giles, A. B., Goluchova, K., Gotz, D., Hartmann, D. H., Haswell, C. A., Inam, S. C., In'Tzand, J. J. M., Jacobs, H. M., Jenke, P. A., Jose, J., Kalamkar, M., Kowalski, A. F., Kuiper, L. M., Lamb, F. K., Laubert, P. P., Maccarone, T. J., Markoff, S. B., Martinez, G., Mchardy, I. M., Medina-Tanco, G., Miller, M. C., Miller, J. M., Mulacova, J., Munoz-Darias, T., Norton, A. J., Olsen, P. E. H., Osborne, J. P., Paredes, J. M., Penacchioni, A. V., Perez, M. A., Perez-Torres, M., Peterson, B. M., Picciotto, A., Piemonte, C., Rachevski, A., Ray, P. S., De La Rie, R., Rischke, D. H., Rodriguez-Gil, P., Rossi, E. M. R., Russell, D. M., Sabau-Graziati, L., Schaffner-Bielich, J., Schnittman, J. D., Schwope, A. D., Seyler, J. -Y., Smith, D. M., Smith, P. J., Steiner, A. W., Stevens, A. L., Strohmayer, T. E., Thielemann, F. K., Torrejon, J. M., Torres, D. F., Vincent, F. H., Wilson-Hodge, C. A., Walk, S. J., Woosley, S. E., Xiao, L., Zorzi, N., Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Department of Psychiatry (Icahn School of Medicine at Mount Sinai) ( ISMMS ), Rutgers, The State University of New Jersey [New Brunswick] ( RUTGERS ), Institut fur Astronomie und Astrophysik, Astrophysique Interactions Multi-échelles ( AIM - UMR 7158 - UMR E 9005 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ), Kanazawa University ( KU ), Department of Earth Sciences, University of Oxford [Oxford], Centre Interdisciplinaire de Nanoscience de Marseille ( CINaM ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Tampere University of Technology [Tampere] ( TUT ), University of Southern Mississippi ( USM ), University of Southampton [Southampton], Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano ( IASF-MI ), Istituto Nazionale di Astrofisica ( INAF ), Istituto di Astrofisica e Planetologia Spaziali ( IAPS ), Laboratoire d'Astrophysique de l'Observatoire Midi-Pyrénées ( LATT ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Swedish Institute of Space Physics [Uppsala] ( IRF ), Osservatorio Astronomico di Brera ( INAF ), Bibliothèque nationale de France ( BnF ), Istituto di Astrofisica Spaziale e Fisica cosmica - Palermo ( IASF-Pa ), ARC Centre of Excellence for Environmental Decisions ( ARC CEED ), The University of Western Australia ( UWA ) -Australian National University ( ANU ) -University of Queensland [Brisbane]-RMIT University [Melbourne]-University of Melbourne, ARC Centre of Excellence for Coral Reef Studies ( CoralCoE ), James Cook University ( JCU ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Anthropologie Moléculaire et Imagerie de Synthèse ( AMIS ), PRES Université de Toulouse-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de synthèse organique ( DCSO ), École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Pathology, University of Alabama at Birmingham, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, INAF-Osservatorio di Cagliari, Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Théorique et Modèles Statistiques ( LPTMS ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace ( LPC2E ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Université Libre de Bruxelles [Bruxelles] ( ULB ), Ocean and Earth Sciences, National Oceanography Centre Southampton, Dublin Institute for advanced studies, 31 Fitzwilliam Place, Dublin 2, Ireland, Mullard Space Science Laboratory ( MSSL ), University College of London [London] ( UCL ), Institut Parisien de Chimie Moléculaire ( IPCM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Chinese Academy of Sciences [Beijing] ( CAS ), Laboratoire Univers et Théories ( LUTH ), Institut national des sciences de l'Univers ( INSU - 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P., Zhang, S. N., Atteia, J. L., Bonnet Bidaud, J. M., Castro Tirado, A. J., D'Aı, A., den Herder, J. W., Gálvez Sanchez, J. L., In't Zand, J. J. M., Nucita, Achille, Seyler, J. Y., Wilson Hodge, C. A., Baldazzi, Giuseppe, Fuschino, Fabio, Bianchi, Stefano, Casella, Piergiorgio, DE ROSA, Alessandra, Giovannini, Gabriele, LA FRANCA, Fabio, Marinucci, Andrea, Paredes, M. J., Schneider, Raffaella, Vietri, Mario, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), M., Feroci, E., Bozzo, S., Brandt, M., Hernanz, M., van der Kli, L. P., Liu, P., Orleanski, M., Pohl, A., Santangelo, S., Schanne, L., Stella, T., Takahashi, H., Tamura, A., Watt, J., Wilm, S., Zane, S. N., Zhang, S., Bhattacharyya, I., Agudo, M., Ahangarianabhari, C., Albertu, M., Alford, A., Alpar, D., Altamirano, L., Alvarez, L., Amati, C., Amoro, N., Andersson, A., Antonelli, A., Argan, R., Artigue, B., Artigue, J. L., Atteia, P., Azzarello, P., Bakala, D., Ballantyne, G., Baldazzi, M., Baldo, S., Balman, M., Barbera, C., van Baren, D., Barret, A., Baykal, M., Begelman, E., Behar, O., Behar, T., Belloni, F., Bernardini, G., Bertuccio, S., Bianchi, A., Bianchini, P., Binko, P., Blay, F., Bocchino, M., Bode, P., Bodin, I., Bombaci, J. M., Bonnet Bidaud, S., Boutlouko, F., Bouyjou, L., Bradley, J., Braga, M. S., Brigg, E., Brown, M., Buballa, N., Bucciantini, L., Burderi, M., Burgay, M., Bursa, C., Budtz Jørgensen, E., Cackett, F., Cadoux, P., Cai, G. A., Caliandro, R., Campana, S., Campana, X., Cao, F., Capitanio, J., Casare, P., Casella, A. J., Castro Tirado, E., Cavazzuti, Y., Cavechi, S., Celestin, P., Cerda Duran, D., Chakrabarty, N., Chamel, F., Château, C., Chen, Y., Chen, J., Chenevez, M., Chernyakova, J., Coker, R., Cole, A., Collura, M., Coriat, R., Cornelisse, L., Costamante, A., Cro, W., Cui, A., Cumming, G., Cusumano, B., Czerny, A., D'Aì, F., D'Ammando, V., D'Elia, Z., Dai, E., Del Monte, A., De Luca, D., De Martino, J. P. C., Dercksen, M., De Pasquale, A., De Rosa, M., Del Santo, S., Di Cosimo, N., Degenaar, J. W., den Herder, S., Diebold, T., Di Salvo, Y., Dong, I., Donnarumma, V., Doroshenko, G., Doyle, S. A., Drake, M., Durant, D., Emmanoulopoulo, T., Enoto, M. H., Erkut, P., Esposito, Y., Evangelista, A., Fabian, M., Falanga, Y., Favre, C., Feldman, R., Fender, H., Feng, V., Ferrari, C., Ferrigno, M., Finger, M. H., Finger, G. W., Fraser, M., Frerick, M., Fullekrug, F., Fuschino, M., Gabler, D. K., Galloway, J. L., Gálvez Sanchez, P., Gandhi, Z., Gao, E., Garcia Berro, B., Gendre, O., Gevin, S., Gezari, A. B., Gile, M., Gilfanov, P., Giommi, G., Giovannini, M., Giroletti, E., Gogu, A., Goldwurm, K., Goluchová, D., Götz, L., Gou, C., Gouiffe, P., Grandi, M., Grassi, J., Greiner, V., Grinberg, P., Groot, M., Gschwender, L., Gualtieri, M., Guedel, C., Guidorzi, L., Guy, D., Haa, P., Haensel, M., Hailey, K., Hamuguchi, F., Hansen, D. H., Hartmann, C. A., Haswell, K., Hebeler, A., Heger, M., Hempel, W., Hermsen, J., Homan, A., Hornstrup, R., Hudec, J., Huovelin, D., Huppenkothen, S. C., Inam, A., Ingram, J. J. M., In't Zand, G., Israel, K., Iwasawa, L., Izzo, H. M., Jacob, F., Jetter, T., Johannsen, P. A., Jenke, P., Jonker, J., Josè, P., Kaaret, K., Kalamkar, E., Kalemci, G., Kanbach, V., Kara, D., Karelin, D., Kataria, L., Keek, T., Kennedy, D., Klochkov, W., Kluzniak, E., Koerding, K., Kokkota, S., Komossa, S., Korpela, C., Kouveliotou, A. F., Kowalski, I., Kreykenbohm, L. M., Kuiper, D., Kunneriath, A., Kurkela, I., Kuvvetli, F., La Franca, C., Labanti, D., Lai, F. K., Lamb, C., Lachaud, P. P., Laubert, F., Lebrun, X., Li, E., Liang, O., Limousin, D., Lin, M., Linare, D., Linder, G., Lodato, F., Longo, F., Lu, N., Lund, T. J., Maccarone, D., Macera, S., Maestre, S., Mahmoodifar, D., Maier, P., Malcovati, J., Malzac, C., Malone, I., Mandel, V., Mangano, A., Manousaki, M., Marelli, J., Margueron, M., Marisaldi, S. B., Markoff, A., Markowitz, A., Marinucci, A., Martindale, G., Martínez, I. M., Mchardy, G., Medina Tanco, M., Mehdipour, A., Melato, M., Mendez, S., Mereghetti, S., Migliari, R., Mignani, M., Michalska, T., Mihara, M. C., Miller, J. M., Miller, T., Mineo, G., Miniutti, S., Morsink, C., Motch, S., Motta, M., Mouchet, G., Mouret, J., Mulačová, F., Muleri, T., Muñoz Daria, I., Negueruela, J., Neilsen, T., Neubert, A. J., Norton, M., Nowak, A., Nucita, P., O'Brien, M., Oertel, P. E. H., Olsen, M., Orienti, M., Orio, M., Orlandini, J. P., Osborne, R., Osten, F., Ozel, L., Pacciani, F., Paerel, S., Paltani, Paolillo, Maurizio, I., Papadaki, A., Papitto, Z., Paragi, J. M., Parede, A., Patruno, B., Paul, F., Pederiva, E., Perinati, A., Pellizzoni, A. V., Penacchioni, U., Peretz, M. A., Perez, M., Perez Torre, B. M., Peterson, V., Petracek, C., Pittori, J., Pon, J., Portell, A., Possenti, K., Postnov, J., Poutanen, M., Prakash, I., Prandoni, H., Le Provost, D., Psalti, J., Pye, J., Qu, D., Rambaud, P., Ramon, G., Ramsay, M., Rapisarda, A., Rashevski, I., Rashevskaya, P. S., Ray, N., Rea, S., Reddy, P., Reig, M., Reina Aranda, R., Remillard, C., Reynold, L., Rezzolla, M., Ribo, R., de la Rie, A., Riggio, A., Rio, D. H., Rischke, P., Rodríguez Gil, J., Rodriguez, R., Rohlf, P., Romano, E. M. R., Rossi, A., Rozanska, A., Rousseau, B., Rudak, D. M., Russell, F., Ryde, L., Sabau Graziati, T., Sakamoto, G., Sala, R., Salvaterra, D., Salvetti, A., Sanna, J., Sandberg, T., Savolainen, S., Scaringi, J., Schaffner Bielich, H., Schatz, J., Schee, C., Schmid, M., Serino, N., Shakura, S., Shore, J. D., Schnittman, R., Schneider, A., Schwenk, A. D., Schwope, A., Sedrakian, J. Y., Seyler, A., Shearer, A., Slowikowska, M., Sim, A., Smith, D. M., Smith, P. J., Smith, M., Sobolewska, V., Sochora, P., Soffitta, P., Soleri, L., Song, A., Spencer, A., Stamerra, B., Stapper, R., Staubert, A. W., Steiner, N., Stergioula, A. L., Steven, G., Stratta, T. E., Strohmayer, Z., Stuchlik, S., Suchy, V., Suleimanov, F., Tamburini, T., Tauri, F., Tavecchio, C., Tenzer, F. K., Thielemann, A., Tiengo, L., Tolo, F., Tombesi, J., Tomsick, G., Torok, J. M., Torrejon, D. F., Torre, E., Torresi, A., Tramacere, I., Traulsen, A., Troi, R., Turolla, S., Turriziani, S., Typel, P., Uter, P., Uttley, A., Vacchi, P., Varniere, S., Vaughan, S., Vercellone, M., Vietri, F. H., Vincent, V., Vrba, D., Walton, J., Wang, Z., Wang, S., Watanabe, R., Wawrzaszek, N., Webb, N., Weinberg, H., Wende, P., Wheatley, R., Wijer, R., Wijnand, M., Wille, C. A., Wilson Hodge, B., Winter, S. J., Walk, K., Wood, S. E., Woosley, X., Wu, R., Xu, W., Yu, F., Yuan, W., Yuan, Y., Yuan, G., Zampa, N., Zampa, L., Zampieri, L., Zdunik, A., Zdziarski, A., Zech, B., Zhang, C., Zhang, S., Zhang, M., Zingale, and F., Zwart
Subjects: X-ray timing, [ SDU.ASTR.GA ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Field of view, Astrophysics, 01 natural sciences, law.invention, law, Observatory, timing, 010303 astronomy & astrophysics, QB, Physics, microchannel plates. PROPORTIONAL COUNTER ARRAY, CALIBRATION, X-ray astronomy, Electronic, Optical and Magnetic Material, Applied Mathematics, Astrophysics::Instrumentation and Methods for Astrophysics, Computer Science Applications1707 Computer Vision and Pattern Recognition, X-ray detectors, Condensed Matter Physics, compact objects, X-ray spectroscopy, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], spectroscopy, Cosmic Vision, [ INFO ] Computer Science [cs], Silicon detector, Astrophysics::High Energy Astrophysical Phenomena, Condensed Matter Physic, Telescope, X-ray, Silicon detectors, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, Electronic, [INFO]Computer Science [cs], Optical and Magnetic Materials, Spectral resolution, DETECTOR, ta115, X-ray astronomy, Silicon detectors, timing, spectroscopy, 010308 nuclear & particles physics, X-ray imaging, Applied Mathematic, Neutron star, QB460-466 Astrophysics, Large Observatory For x-ray Timing (LOFT), Large Area Detector (LAD), Wide Field Monitor (WFM), Large Area Silicon Drift Detectors (SDD), Gamma-ray burst
Abstract: The Large Observatory For x-ray Timing (LOFT) is a mission concept which was proposed to ESA as M3 and M4 candidate in the framework of the Cosmic Vision 2015-2025 program. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument and the uniquely large field of view of its wide field monitor, LOFT will be able to study the behaviour of matter in extreme conditions such as the strong gravitational field in the innermost regions close to black holes and neutron stars and the supra-nuclear densities in the interiors of neutron stars. The science payload is based on a Large Area Detector (LAD, >8m2 effective area, 2-30 keV, 240 eV spectral resolution, 1 degree collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g., GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the current technical and programmatic status of the mission. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Published: 2016
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3. The Large Observatory For x-ray Timing

Author: Feroci, M, den Herder, JW, Bozzo, E, Barret, D, Brandt, S, Hernanz, M, van der Klis, M, Pohl, M, Santangelo, A, Stella, L, Watts, A, Wilms, J, Zane, S, Ahangarianabhari, M, Albertus, C, Alford, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Artigues, B, Atteia, J-L, Azzarello, P, Bakala, P, Baldazzi, G, Balman, S, Barbera, M, van Baren, C, Bhattacharyya, S, Baykal, A, Belloni, T, Bernardini, F, Bertuccio, G, Bianchi, S, Bianchini, A, Binko, P, Blay, P, Bocchino, F, Bodin, P, Bombaci, I, Bidaud, J-MB, Boutloukos, S, Bradley, L, Braga, J, Brown, E, Bucciantini, N, Burderi, L, Burgay, M, Bursa, M, Budtz-Jorgensen, C, Cackett, E, Cadoux, FR, Cais, P, Caliandro, GA, Campana, R, Campana, S, Capitanio, F, Casares, J, Casella, P, Castro-Tirado, AJ, Cavazzuti, E, Cerda-Duran, P, Chakrabarty, D, Chateau, F, Chenevez, J, Coker, J, Cole, R, Collura, A, Cornelisse, R, Courvoisier, T, Cros, A, Cumming, A, Cusumano, G, D'Ai, A, D'Elia, V, Del Monte, E, De Luca, A, De Martino, D, Dercksen, JPC, De Pasquale, M, De Rosa, A, Del Santo, M, Di Cosimo, S, Diebold, S, Di Salvo, T, Donnarumma, I, Drago, A, Durant, M, Emmanoulopoulos, D, Erkut, MH, Esposito, P, Evangelista, Y, Fabian, A, Falanga, M, Favre, Y, Feldman, C, Ferrari, V, Ferrigno, C, Finger, M, Finger, MH, Fraser, GW, Frericks, M, Fuschino, F, Gabler, M, Galloway, DK, Sanchez, JLG, Garcia-Berro, E, Gendrel, B, Gezari, S, Giles, AB, Gilfanov, M, Giommi, P, Giovannini, G, Giroletti, M, Gogus, E, Goldwurm, A, Goluchova, K, Goetz, D, Gouiffes, C, Grassi, M, Groot, P, Gschwender, M, Gualtieri, L, Guidorzi, C, Guy, L, Haas, D, Haense, P, Hailey, M, Hansen, F, Hartmann, DH, Haswell, CA, Hebeler, K, Heger, A, Hermsen, W, Homan, J, Hornstrup, A, Hudec, R, Huovelin, J, Ingram, A, in't Zand, JJM, Israel, G, Iwasawa, K, Izzo, L, Jacobs, HM, Jetter, F, Johannsen, T, Jonker, P, Jose, J, Kaaret, P, Kanbach, G, Karas, V, Karelin, D, Kataria, D, Keek, L, Kennedy, T, Klochkov, D, Kluzniak, W, Kokkotas, K, Korpela, S, Kouveliotou, C, Kreykenbohm, I, Kuiper, LM, Kuvvetli, I, Labanti, C, Lai, D, Lamb, FK, Laubert, PP, Lebrun, F, Lin, D, Linder, D, Lodato, G, Longo, F, Lund, N, Maccarone, TJ, Macera, D, Maestre, S, Mahmoodifar, S, Maier, D, Malcovati, P, Mandel, I, Mangano, V, Manousakis, A, Marisaldi, M, Markowitz, A, Martindale, A, Matt, G, McHardy, IM, Melatos, A, Mendez, M, Mereghetti, S, Michalska, M, Migliari, S, Mignani, R, Miller, MC, Miller, JM, Mineo, T, Miniutti, G, Morsink, S, Motch, C, Motta, S, Mouchet, M, Mouret, G, Mulacova, J, Muleri, F, Munoz-Darias, T, Negueruela, I, Neilsen, J, Norton, AJ, Nowak, M, O'Brien, P, Olsen, PEH, Orientil, M, Orio, M, Orlandini, M, Orleanski, P, Osborne, JP, Osten, R, Ozel, F, Pacciani, L, Paolillo, M, Papitto, A, Paredes, JM, Patruno, A, Paul, B, Perinati, E, Pellizzoni, A, Penacchioni, AV, Perez, MA, Petracek, V, Pittori, C, Pons, J, Portell, J, Possenti, A, Poutanen, J, Prakash, M, Le Provost, P, Psaltis, D, Rambaud, D, Ramon, P, Ramsay, G, Rapisarda, M, Rachevski, A, Rashevskaya, I, Ray, PS, Rea, N, Reddy, S, Reig, P, Aranda, MR, Remillard, R, Reynolds, C, Rezzolla, L, Ribo, M, de la Rie, R, Riggio, A, Rios, A, Rodriguez-Gil, P, Rodriguez, J, Rohlfs, R, Romano, P, Rossi, EMR, Rozanska, A, Rousseau, A, Ryde, F, Sabau-Graziati, L, Sala, G, Salvaterra, R, Sanna, A, Sandberg, J, Scaringi, S, Schanne, S, Schee, J, Schmid, C, Shore, S, Schneider, R, Schwenk, A, Schwope, AD, Seyler, J-Y, Shearer, A, Smith, A, Smith, DM, Smith, PJ, Sochora, V, Soffitta, P, Soleri, P, Spencer, A, Stappers, B, Steiner, AW, Stergioulas, N, Stratta, G, Strohmayer, TE, Stuchlik, Z, Suchy, S, Sulemainov, V, Takahashi, T, Tamburini, F, Tauris, T, Tenzer, C, Tolos, L, Tombesi, F, Tomsick, J, Torok, G, Torrejon, JM, Torres, DF, Tramacere, A, Trois, A, Turolla, R, Turriziani, S, Uter, P, Uttley, P, Vacchi, A, Varniere, P, Vaughan, S, Vercellone, S, Vrba, V, Walton, D, Watanabe, S, Wawrzaszek, R, Webb, N, Weinberg, N, Wende, H, Wheatley, P, Wijers, R, Wijnands, R, Wie, M, Wilson-Hodge, CA, Winter, B, Wood, K, Zampa, G, Zampa, N, Zampieri, L, Zdunik, L, Zdziarski, A, Zhang, B, Zwart, F, Ayre, M, Boenke, T, van Damme, CC, Kuulkers, E, Lumb, D, Feroci, M, den Herder, JW, Bozzo, E, Barret, D, Brandt, S, Hernanz, M, van der Klis, M, Pohl, M, Santangelo, A, Stella, L, Watts, A, Wilms, J, Zane, S, Ahangarianabhari, M, Albertus, C, Alford, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Artigues, B, Atteia, J-L, Azzarello, P, Bakala, P, Baldazzi, G, Balman, S, Barbera, M, van Baren, C, Bhattacharyya, S, Baykal, A, Belloni, T, Bernardini, F, Bertuccio, G, Bianchi, S, Bianchini, A, Binko, P, Blay, P, Bocchino, F, Bodin, P, Bombaci, I, Bidaud, J-MB, Boutloukos, S, Bradley, L, Braga, J, Brown, E, Bucciantini, N, Burderi, L, Burgay, M, Bursa, M, Budtz-Jorgensen, C, Cackett, E, Cadoux, FR, Cais, P, Caliandro, GA, Campana, R, Campana, S, Capitanio, F, Casares, J, Casella, P, Castro-Tirado, AJ, Cavazzuti, E, Cerda-Duran, P, Chakrabarty, D, Chateau, F, Chenevez, J, Coker, J, Cole, R, Collura, A, Cornelisse, R, Courvoisier, T, Cros, A, Cumming, A, Cusumano, G, D'Ai, A, D'Elia, V, Del Monte, E, De Luca, A, De Martino, D, Dercksen, JPC, De Pasquale, M, De Rosa, A, Del Santo, M, Di Cosimo, S, Diebold, S, Di Salvo, T, Donnarumma, I, Drago, A, Durant, M, Emmanoulopoulos, D, Erkut, MH, Esposito, P, Evangelista, Y, Fabian, A, Falanga, M, Favre, Y, Feldman, C, Ferrari, V, Ferrigno, C, Finger, M, Finger, MH, Fraser, GW, Frericks, M, Fuschino, F, Gabler, M, Galloway, DK, Sanchez, JLG, Garcia-Berro, E, Gendrel, B, Gezari, S, Giles, AB, Gilfanov, M, Giommi, P, Giovannini, G, Giroletti, M, Gogus, E, Goldwurm, A, Goluchova, K, Goetz, D, Gouiffes, C, Grassi, M, Groot, P, Gschwender, M, Gualtieri, L, Guidorzi, C, Guy, L, Haas, D, Haense, P, Hailey, M, Hansen, F, Hartmann, DH, Haswell, CA, Hebeler, K, Heger, A, Hermsen, W, Homan, J, Hornstrup, A, Hudec, R, Huovelin, J, Ingram, A, in't Zand, JJM, Israel, G, Iwasawa, K, Izzo, L, Jacobs, HM, Jetter, F, Johannsen, T, Jonker, P, Jose, J, Kaaret, P, Kanbach, G, Karas, V, Karelin, D, Kataria, D, Keek, L, Kennedy, T, Klochkov, D, Kluzniak, W, Kokkotas, K, Korpela, S, Kouveliotou, C, Kreykenbohm, I, Kuiper, LM, Kuvvetli, I, Labanti, C, Lai, D, Lamb, FK, Laubert, PP, Lebrun, F, Lin, D, Linder, D, Lodato, G, Longo, F, Lund, N, Maccarone, TJ, Macera, D, Maestre, S, Mahmoodifar, S, Maier, D, Malcovati, P, Mandel, I, Mangano, V, Manousakis, A, Marisaldi, M, Markowitz, A, Martindale, A, Matt, G, McHardy, IM, Melatos, A, Mendez, M, Mereghetti, S, Michalska, M, Migliari, S, Mignani, R, Miller, MC, Miller, JM, Mineo, T, Miniutti, G, Morsink, S, Motch, C, Motta, S, Mouchet, M, Mouret, G, Mulacova, J, Muleri, F, Munoz-Darias, T, Negueruela, I, Neilsen, J, Norton, AJ, Nowak, M, O'Brien, P, Olsen, PEH, Orientil, M, Orio, M, Orlandini, M, Orleanski, P, Osborne, JP, Osten, R, Ozel, F, Pacciani, L, Paolillo, M, Papitto, A, Paredes, JM, Patruno, A, Paul, B, Perinati, E, Pellizzoni, A, Penacchioni, AV, Perez, MA, Petracek, V, Pittori, C, Pons, J, Portell, J, Possenti, A, Poutanen, J, Prakash, M, Le Provost, P, Psaltis, D, Rambaud, D, Ramon, P, Ramsay, G, Rapisarda, M, Rachevski, A, Rashevskaya, I, Ray, PS, Rea, N, Reddy, S, Reig, P, Aranda, MR, Remillard, R, Reynolds, C, Rezzolla, L, Ribo, M, de la Rie, R, Riggio, A, Rios, A, Rodriguez-Gil, P, Rodriguez, J, Rohlfs, R, Romano, P, Rossi, EMR, Rozanska, A, Rousseau, A, Ryde, F, Sabau-Graziati, L, Sala, G, Salvaterra, R, Sanna, A, Sandberg, J, Scaringi, S, Schanne, S, Schee, J, Schmid, C, Shore, S, Schneider, R, Schwenk, A, Schwope, AD, Seyler, J-Y, Shearer, A, Smith, A, Smith, DM, Smith, PJ, Sochora, V, Soffitta, P, Soleri, P, Spencer, A, Stappers, B, Steiner, AW, Stergioulas, N, Stratta, G, Strohmayer, TE, Stuchlik, Z, Suchy, S, Sulemainov, V, Takahashi, T, Tamburini, F, Tauris, T, Tenzer, C, Tolos, L, Tombesi, F, Tomsick, J, Torok, G, Torrejon, JM, Torres, DF, Tramacere, A, Trois, A, Turolla, R, Turriziani, S, Uter, P, Uttley, P, Vacchi, A, Varniere, P, Vaughan, S, Vercellone, S, Vrba, V, Walton, D, Watanabe, S, Wawrzaszek, R, Webb, N, Weinberg, N, Wende, H, Wheatley, P, Wijers, R, Wijnands, R, Wie, M, Wilson-Hodge, CA, Winter, B, Wood, K, Zampa, G, Zampa, N, Zampieri, L, Zdunik, L, Zdziarski, A, Zhang, B, Zwart, F, Ayre, M, Boenke, T, van Damme, CC, Kuulkers, E, and Lumb, D
Abstract: The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study
Published: 2014

4. Time to nursing home admission and death in people with dementia: systematic review and meta-analysis.

Author: Brück CC, Mooldijk SS, Kuiper LM, Sambou ML, Licher S, Mattace-Raso F, and Wolters FJ
Subjects: Humans, Male, Aged, Time Factors, Female, Patient Admission statistics & numerical data, Aged, 80 and over, Prognosis, Nursing Homes statistics & numerical data, Dementia mortality
Abstract: Objective: To summarise available evidence on time to nursing home admission and death among people with dementia, and to explore prognostic indicators., Design: Systematic review and meta-analysis., Data Sources: Medline, Embase, Web of Science, Cochrane, and Google Scholar from inception to 4 July 2024., Eligibility Criteria for Selecting Studies: Longitudinal studies on survival or nursing home admission in people with dementia. Studies with fewer than 150 participants, recruitment during acute hospital admission, or less than one year of follow-up were excluded., Results: 19 307 articles were identified and 261 eligible studies included. 235 reported on survival among 5 553 960 participants and 79 reported on nursing home admission among 352 990 participants. Median survival from diagnosis appeared to be strongly dependent on age, ranging from 8.9 years at mean age 60 for women to 2.2 years at mean age 85 for men. Women overall had shorter survival than men (mean difference 4.1 years (95% confidence interval 2.1 to 6.1)), which was attributable to later age at diagnosis in women. Median survival was 1.2 to 1.4 years longer in Asia than in the US and Europe, and 1.4 years longer for Alzheimer's disease compared with other types of dementia. Compared with studies before 2000, survival was longer in contemporary clinic based studies (P trend =0.02), but not in community based studies. Taken together, variation in reported clinical characteristics and study methodology explained 51% of heterogeneity in survival. Median time to nursing home admission was 3.3 years (interquartile range 1.9 to 4.0). 13% of people were admitted in the first year after diagnosis, increasing to 57% at five years, but few studies appropriately accounted for competing mortality risk when assessing admission rates., Conclusions: The average life expectancy of people with dementia at time of diagnosis ranged from 5.7 years at age 65 to 2.2 at age 85 in men and from 8.0 to 4.5, respectively, in women. About one third of remaining life expectancy was lived in nursing homes, with more than half of people moving to a nursing home within five years after a dementia diagnosis. Prognosis after a dementia diagnosis is highly dependent on personal and clinical characteristics, offering potential for individualised prognostic information and care planning., Systematic Review Registration: PROSPERO CRD42022341507., Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: FJW was supported by a research fellowship from the Alzheimer’s Association; no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2025
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5. Advanced glycation end-products and metabolomics are independently associated with frailty: the longitudinal Doetinchem Cohort Study.

Author: Kuiper LM, Picavet HSJ, Rietman ML, Dollé MET, and Verschuren WMM
Abstract: Skin autofluorescence (SAF), reflecting advanced glycation end-products' accumulation in tissue, has been proposed as a non-invasive aging biomarker. Yet, SAF has not been compared to well-established blood-based aging biomarkers such as MetaboHealth in association with frailty. Furthermore, no previous study determined the longitudinal association of SAF with frailty. We used 2382 Doetinchem Cohort Study participants' (aged 46.0 to 85.4) cross-sectional data, of whom 1654 had longitudinal SAF measurements. SAF was measured using the AGE reader™. MetaboHealth was calculated on 1H-NMR-metabolomics. Linear regressions were used for the associations of SAF and MetaboHealth on the 36-deficit frailty index and logistic regressions for being pre-frail or frail as determined by the frailty phenotype. Longitudinal associations were determined by an interaction term between age and SAF in a linear mixed model. SAF and MetaboHealth were associated with higher odds of pre-frailty (odd ratios per standard deviation SAF: 1.21(1.10;1.32), MetaboHealth: 1.35(1.24;1.49)) and frailty (SAF: 1.70(1.41;2.06), MetaboHealth: 1.90(1.57;2.32)). When mutually adjusted, both aging biomarkers remained associated with pre-frailty (SAF: 1.16(1.05;1.27), MetaboHealth 1.33(1.21;1.46)) and frailty (SAF: 1.52(1.25;1.85), MetaboHealth: 1.75(1.43;2.14)). Additionally, SAF and MetaboHealth were associated with higher frailty index scores (percentage increase per standard deviation SAF:1.35(1.00;1.70), MetaboHealth: 1.87(1.54;2.20)), also after mutual adjustment (SAF: 1.02(0.68;1.37), MetaboHealth: 1.69(1.35;2.02)). SAF was also longitudinally associated with the frailty index (percentage per unit/year increase 0.12(0.07;0.16)). The mutual independence of SAF and MetaboHealth implies they capture distinct aspects of the aging process. Altogether, these findings emphasize SAF's clinical potential as an age-related decline biomarker, which could be further enhanced when combined with MetaboHealth., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.)
Published: 2024
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6. Association between metabolomics-based biomarker scores and 10-year cognitive decline in men and women. The Doetinchem Cohort Study.

Author: Smit AP, Herber GM, Kuiper LM, Rietman ML, Wesenhagen KEJ, Picavet HSJ, Slagboom PE, and Verschuren WMM
Subjects: Humans, Male, Female, Middle Aged, Aged, Sex Factors, Age Factors, Netherlands epidemiology, Cognitive Aging psychology, Time Factors, Aging psychology, Risk Factors, Longitudinal Studies, Metabolomics methods, Biomarkers blood, Cognitive Dysfunction diagnosis, Cognitive Dysfunction psychology, Cognitive Dysfunction epidemiology, Cognition
Abstract: Background: Metabolomic scores based on age (MetaboAge) and mortality (MetaboHealth) are considered indicators of overall health, but their association with cognition in the general population is unknown. Therefore, the association between MetaboAge/MetaboHealth and level and decline in cognition was studied, as were differences between men and women., Methods: Data of 2821 participants (50% women, age range 45-75) from the Doetinchem Cohort Study was used. MetaboAge and MetaboHealth were calculated from 1H-NMR metabolomics data at baseline. Cognitive domain scores (memory, flexibility and processing speed) and global cognitive functioning were available over a 10-year period. The association between MetaboAge/MetaboHealth and level of cognitive functioning was studied using linear regressions while for the association between MetaboAge/MetaboHealth and cognitive decline longitudinal linear mixed models were used. Analyses were adjusted for demographics and lifestyle factors., Results: Higher MetaboAge, indicating poorer metabolomic ageing, was only associated with lower levels of processing speed in men. Higher MetaboHealth, indicating poorer immune-metabolic health, was associated with lower levels of cognitive functioning for all three domains and global cognitive functioning in both men and women. Only in men, MetaboHealth was also associated with 10-year decline in flexibility, processing speed and global cognition. Metabolites that contributed to the observed associations were in men mainly markers of protein metabolism, and in women mainly markers of lipid metabolism and inflammatory metabolites., Conclusions: MetaboHealth, not MetaboAge, was associated with cognitive functioning independent of conventional risk factors. Individual metabolites affect cognitive functioning differently in men and women, suggesting sex-specific pathophysiological pathways underlying cognitive functioning., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society.)
Published: 2024
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7. Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts.

Author: Kuiper LM, Smit AP, Bizzarri D, van den Akker EB, Reinders MJT, Ghanbari M, van Rooij JGJ, Voortman T, Rivadeneira F, Dollé MET, Herber GCM, Rietman ML, Picavet HSJ, van Meurs JBJ, and Verschuren WMM
Subjects: Humans, Male, Female, Middle Aged, Cross-Sectional Studies, Longitudinal Studies, Prospective Studies, Metabolomics methods, Aged, Exercise physiology, Life Style, Biomarkers blood, Biomarkers metabolism, Aging metabolism, Aging physiology
Abstract: Biological age uses biophysiological information to capture a person's age-related risk of adverse outcomes. MetaboAge and MetaboHealth are metabolomics-based biomarkers of biological age trained on chronological age and mortality risk, respectively. Lifestyle factors contribute to the extent chronological and biological age differ. The association of lifestyle factors with MetaboAge and MetaboHealth, potential sex differences in these associations, and MetaboAge's and MetaboHealth's sensitivity to lifestyle changes have not been studied yet. Linear regression analyses and mixed-effect models were used to examine the cross-sectional and longitudinal associations of scaled lifestyle factors with scaled MetaboAge and MetaboHealth in 24,332 middle-aged participants from the Doetinchem Cohort Study, Rotterdam Study, and UK Biobank. Random-effect meta-analyses were performed across cohorts. Repeated metabolomics measurements had a ten-year interval in the Doetinchem Cohort Study and a five-year interval in the UK Biobank. In the first study incorporating longitudinal information on MetaboAge and MetaboHealth, we demonstrate associations between current smoking, sleeping ≥8 hours/day, higher BMI, and larger waist circumference were associated with higher MetaboHealth, the latter two also with higher MetaboAge. Furthermore, adhering to the dietary and physical activity guidelines were inversely associated with MetaboHealth. Lastly, we observed sex differences in the associations between alcohol use and MetaboHealth., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests., (Copyright © 2024. Published by Elsevier B.V.)
Published: 2024
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8. Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants.

Author: Kuiper LM, Shi W, Verlouw J, Hong YS, Arp P, Puiu D, Broer L, Xie J, Newcomb C, Rich SS, Taylor KD, Rotter JI, Bader JS, Guallar E, van Meurs JBJ, and Arking DE
Abstract: A common feature of human aging is the acquisition of somatic mutations, and mitochondria are particularly prone to mutation due to their inefficient DNA repair and close proximity to reactive oxygen species, leading to a state of mitochondrial DNA heteroplasmy 1,2 . Cross-sectional studies have demonstrated that detection of heteroplasmy increases with participant age 3 , a phenomenon that has been attributed to genetic drift 4-7 . In this first large-scale longitudinal study, we measured heteroplasmy in two prospective cohorts (combined n=1405) at two timepoints (mean time between visits, 8.6 years), demonstrating that deleterious heteroplasmies were more likely to increase in variant allele fraction (VAF). We further demonstrated that increase in VAF was associated with increased risk of overall mortality. These results challenge the claim that somatic mtDNA mutations arise mainly due to genetic drift, instead demonstrating positive selection for predicted deleterious mutations at the cellular level, despite an negative impact on overall mortality.
Published: 2024
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9. Past or Present; Which Exposures Predict Metabolomic Aging Better? The Doetinchem Cohort Study.

Author: Smit AP, Herber GM, Kuiper LM, Loef B, Picavet HSJ, and Verschuren WMM
Subjects: Male, Humans, Female, Cohort Studies, Cross-Sectional Studies, Smoking, Aging, Metabolomics
Abstract: People age differently. Differences in aging might be reflected by metabolites, also known as metabolomic aging. Predicting metabolomic aging is of interest in public health research. However, the added value of longitudinal over cross-sectional predictors of metabolomic aging is unknown. We studied exposome-related exposures as potential predictors of metabolomic aging, both cross-sectionally and longitudinally in men and women. We used data from 4 459 participants, aged 36-75 of Round 4 (2003-2008) of the long-running Doetinchem Cohort Study (DCS). Metabolomic age was calculated with the MetaboHealth algorithm. Cross-sectional exposures were demographic, biological, lifestyle, and environmental at Round 4. Longitudinal exposures were based on the average exposure over 15 years (Round 1 [1987-1991] to 4), and trend in these exposure over time. Random Forest was performed to identify model performance and important predictors. Prediction performances were similar for cross-sectional and longitudinal exposures in both men (R2 6.8 and 5.8, respectively) and women (R2 14.8 and 14.4, respectively). Biological and diet exposures were most predictive for metabolomic aging in both men and women. Other important predictors were smoking behavior for men and contraceptive use and menopausal status for women. Taking into account history of exposure levels (longitudinal) had no added value over cross-sectionally measured exposures in predicting metabolomic aging in the current study. However, the prediction performances of both models were rather low. The most important predictors for metabolomic aging were from the biological and lifestyle domain and differed slightly between men and women., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America.)
Published: 2024
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10. Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk.

Author: Kuiper LM, Polinder-Bos HA, Bizzarri D, Vojinovic D, Vallerga CL, Beekman M, Dollé ET, Ghanbari M, Voortman T, Reinders MJT, Verschuren WMM, Slagboom PE, van den Akker EB, and van Meurs JBJ
Subjects: Humans, Aged, Prospective Studies, Biomarkers, Aging genetics, Epigenesis, Genetic, DNA Methylation, Frailty genetics
Abstract: Biological age captures a person's age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but here we present a large-scale study comparing them. In 2 prospective cohorts (n = 3 222), we compared epigenetic (DNAm Horvath, DNAm Hannum, DNAm Lin, DNAm epiTOC, DNAm PhenoAge, DNAm DunedinPoAm, DNAm GrimAge, and DNAm Zhang) and metabolomic-based (MetaboAge and MetaboHealth) biomarkers in reflection of biological age, as represented by 5 frailty measures and overall mortality. Biomarkers trained on outcomes with biophysiological and/or mortality information outperformed age-trained biomarkers in frailty reflection and mortality prediction. DNAm GrimAge and MetaboHealth, trained on mortality, showed the strongest association with these outcomes. The associations of DNAm GrimAge and MetaboHealth with frailty and mortality were independent of each other and of the frailty score mimicking clinical geriatric assessment. Epigenetic, metabolomic, and clinical biological age markers seem to capture different aspects of aging. These findings suggest that mortality-trained molecular markers may provide novel phenotype reflecting biological age and strengthen current clinical geriatric health and well-being assessment., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America.)
Published: 2023
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11. C-factor: a summary measure for systemic arterial calcifications.

Author: Kuiper LM, Ikram MK, Kavousi M, Vernooij MW, Ikram MA, and Bos D
Subjects: Aged, Aortic Diseases mortality, Carotid Artery Diseases mortality, Coronary Artery Disease mortality, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Principal Component Analysis, Prognosis, Risk Assessment, Risk Factors, Severity of Illness Index, Vascular Calcification mortality, Vertebrobasilar Insufficiency mortality, Aortic Diseases diagnostic imaging, Aortography, Carotid Artery Diseases diagnostic imaging, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Multidetector Computed Tomography, Vascular Calcification diagnostic imaging, Vertebrobasilar Insufficiency diagnostic imaging
Abstract: Background: Arterial calcification, the hallmark of arteriosclerosis, has a widespread distribution in the human body with only moderate correlation among sites. Hitherto, a single measure capturing the systemic burden of arterial calcification was lacking. In this paper, we propose the C-factor as an overall measure of calcification burden., Methods: To quantify calcification in the coronary arteries, aortic arch, extra- and intracranial carotid arteries, and vertebrobasilar arteries, 2384 Rotterdam Study participants underwent cardiac and extra-cardiac non-enhanced CT. We performed principal component analyses on the calcification volumes of all twenty-six possible combinations of these vessel beds. Each analysis' first principal component represents the C-factor. Subsequently, we determined the correlation between the C-factor derived from all vessel beds and the other C-factors with intraclass correlation coefficient (ICC) analyses. Finally, we examined the association of the C-factor and calcification in the separate vessel beds with cardiovascular, non-cardiovascular, and overall mortality using Cox-regression analyses., Results: The ICCs ranged from 0.80 to 0.99. Larger calcification volumes and a higher C-factor were all individually associated with higher risk of cardiovascular, non-cardiovascular, and overall mortality. When included simultaneously in a model, the C-factor was still associated with all three mortality types (adjusted hazard ratio per standard deviation increase (HR) > 1.52), whereas associations of the separate vessel beds with mortality attenuated substantially (HR < 1.26)., Conclusions: The C-factor summarizes the systemic component of arterial calcification on an individual level and appears robust among different combinations of vessel beds. Importantly, when mutually adjusted, the C-factor retains its strength of association with mortality while the site-specific associations attenuate.
Published: 2021
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12. Displaying chest X-ray by beamer or monitor: comparison of diagnostic accuracy for subtle abnormalities.

Author: Kuiper LM, Thijs A, and Smulders YM
Subjects: Confidence Intervals, Humans, Radiography, Thoracic instrumentation, Reference Values, Sensitivity and Specificity, Lung diagnostic imaging, Radiography, Thoracic methods, Thoracic Diseases diagnostic imaging
Abstract: Background: The advent of beamer projection of radiological images raises the issue of whether such projection compromises diagnostic accuracy. The purpose of this study was to evaluate whether beamer projection of chest X-rays is inferior to monitor display., Methods: We selected 53 chest X-rays with subtle abnormalities and 15 normal X-rays. The images were independently judged by a senior radiologist and a senior pulmonologist with a state-of-art computer monitor. We used their unanimous or consensus judgment as the reference test. Subsequently, four observers (one senior pulmonologist, one senior radiologist and one resident from each speciality) judged these X-rays on a standard clinical computer monitor and with beamer projection. We compared the number of correct results for each method., Results: Overall, the sensitivity and specificity did not differ between monitor and beamer projection. Separate analyses in senior and junior examiners suggested that senior examiners had a moderate loss of diagnostic accuracy (8% lower sensitivity, pp<0.05, and 6% lower specificity, p=ns) associated with the use of beamer projection, whereas juniors showed similar performance on both imaging modalities., Conclusion: These initial data suggest that beamer projection may be associated with a small loss of diagnostic accuracy in specific subgroups of physicians. This finding illustrates the need for more extensive studies.
Published: 2012

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12 results on '"Kuiper LM"'

1. Past or Present; Which Exposures Predict Metabolomic Aging Better?:The Doetinchem Cohort Study

2. The LOFT mission concept: a status update

3. The Large Observatory For x-ray Timing

4. Time to nursing home admission and death in people with dementia: systematic review and meta-analysis.

5. Advanced glycation end-products and metabolomics are independently associated with frailty: the longitudinal Doetinchem Cohort Study.

6. Association between metabolomics-based biomarker scores and 10-year cognitive decline in men and women. The Doetinchem Cohort Study.

7. Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts.

8. Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants.

9. Past or Present; Which Exposures Predict Metabolomic Aging Better? The Doetinchem Cohort Study.

10. Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk.

11. C-factor: a summary measure for systemic arterial calcifications.

12. Displaying chest X-ray by beamer or monitor: comparison of diagnostic accuracy for subtle abnormalities.

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