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3. A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

Author

Venema, Wouter J., primary, Hiddingh, Sanne, additional, van Loosdregt, Jorg, additional, Bowes, John, additional, Balliu, Brunilda, additional, de Boer, Joke H., additional, Ossewaarde-van Norel, Jeannette, additional, Thompson, Susan D., additional, Langefeld, Carl D., additional, de Ligt, Aafke, additional, van der Veken, Lars T., additional, Krijger, Peter H.L., additional, de Laat, Wouter, additional, and Kuiper, Jonas J.W., additional

Published
2023
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4. Elevated Plasma Complement Factors in CRB1-associated Inherited Retinal Dystrophies

Author

Moekotte, Lude, primary, Boer, Joke H., additional, Hiddingh, Sanne, additional, Ligt, Aafke, additional, Nguyen, Xuan-Thanh-An, additional, Hoyng, Carel B., additional, Inglehearn, Chris F., additional, McKibbin, Martin, additional, Lamey, Tina M., additional, Thompson, Jennifer A., additional, Chen, Fred K., additional, McLaren, Terri L., additional, AlTalbishi, Alaa, additional, Panneman, Daan M., additional, Boonen, Erica G.M., additional, Banfi, Sandro, additional, Bocquet, Beatrice, additional, Meunier, Isabelle, additional, Baere, Elfride, additional, Koenekoop, Robert, additional, Oldak, Monika, additional, Rivolta, Carlo, additional, Roberts, Lisa, additional, Ramesar, Raj, additional, Strupaite-Sileikiene, Rasa, additional, Kohl, Susanne, additional, Farrar, G. Jane, additional, Vugt, Marion, additional, Setten, Jessica, additional, Roosing, Susanne, additional, Born, L. Ingeborgh, additional, Boon, Camiel J.F., additional, Genderen, Maria M., additional, and Kuiper, Jonas J.W., additional

Published
2023
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7. Acis-regulatory element regulatesERAP2expression through autoimmune disease risk SNPs

Author

Venema, Wouter J., primary, Hiddingh, Sanne, additional, van Loosdregt, Jorg, additional, Bowes, John, additional, Balliu, Brunilda, additional, de Boer, Joke H., additional, Norel, Jeanette Ossewaarde-van, additional, Thompson, Susan. D., additional, Langefeld, Carl D., additional, van der Veken, Lars T., additional, Sofiadis, Konstantinos, additional, Krijger, Peter H.L., additional, de Laat, Wouter, additional, and Kuiper, Jonas J.W., additional

Published
2023
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8. Association of Risk Variants in the CFH Gene With Elevated Levels of Coagulation and Complement Factors in Idiopathic Multifocal Choroiditis

Author

de Groot, Evianne L., Ossewaarde-van Norel, Jeannette, de Boer, Joke H., Hiddingh, Sanne, Bakker, Bjorn, van Huet, Ramon A.C., Ten Dam-van Loon, Ninette H., Thiadens, Alberta A.H.J., Meester-Smoor, Magda A., de Jong-Hesse, Yvonne, Los, Leonoor I., den Hollander, Anneke I., Boon, Camiel J.F., Kiemeney, Lambertus A., van Eijk, Kristel R., Bakker, Mark K., Hoyng, Carel B., Kuiper, Jonas J.W., de Groot, Evianne L., Ossewaarde-van Norel, Jeannette, de Boer, Joke H., Hiddingh, Sanne, Bakker, Bjorn, van Huet, Ramon A.C., Ten Dam-van Loon, Ninette H., Thiadens, Alberta A.H.J., Meester-Smoor, Magda A., de Jong-Hesse, Yvonne, Los, Leonoor I., den Hollander, Anneke I., Boon, Camiel J.F., Kiemeney, Lambertus A., van Eijk, Kristel R., Bakker, Mark K., Hoyng, Carel B., and Kuiper, Jonas J.W.

Abstract

Importance: Idiopathic multifocal choroiditis (MFC) is poorly understood, thereby hindering optimal treatment and monitoring of patients. Objective: To identify the genes and pathways associated with idiopathic MFC. Design, Setting, and Participants: This was a case-control genome-wide association study (GWAS) and protein study of blood plasma samples conducted from March 2006 to February 2022. This was a multicenter study involving 6 Dutch universities. Participants were grouped into 2 cohorts: cohort 1 consisted of Dutch patients with idiopathic MFC and controls, and cohort 2 consisted of patients with MFC and controls. Plasma samples from patients with idiopathic MFC who had not received treatment were subjected to targeted proteomics. Idiopathic MFC was diagnosed according to the Standardization of Uveitis Nomenclature (SUN) Working Group guidelines for punctate inner choroidopathy and multifocal choroiditis with panuveitis. Data were analyzed from July 2021 to October 2022. Main outcomes and measures: Genetic variants associated with idiopathic MFC and risk variants associated with plasma protein concentrations in patients. Results: This study included a total of 4437 participants in cohort 1 (170 [3.8%] Dutch patients with idiopathic MFC and 4267 [96.2%] controls; mean [SD] age, 55 [18] years; 2443 female [55%]) and 1344 participants in cohort 2 (52 [3.9%] patients with MFC and 1292 [96.1%] controls; 737 male [55%]). The primary GWAS association mapped to the CFH gene with genome-wide significance (lead variant the A allele of rs7535263; odds ratio [OR], 0.52; 95% CI, 0.41-0.64; P = 9.3 × 10-9). There was no genome-wide significant association with classical human leukocyte antigen (HLA) alleles (lead classical allele, HLA-A*31:01; P = .002). The association with rs7535263 showed consistent direction of effect in an independent cohort of 52 cases and 1292 control samples (combined meta-analysis OR, 0.58; 95% CI, 0.38-0.77; P = 3.0 × 10-8). In proteomic anal

Published
2023

9. CRB1-Associated Retinal Dystrophy Patients Have Expanded Lewis Glycoantigen-Positive T Cells

Author

Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Child Health, Moekotte, Lude, Kuiper, Jonas J.W., Hiddingh, Sanne, Nguyen, Xuan Thanh An, Boon, Camiel J.F., van den Born, L. Ingeborgh, de Boer, Joke H., van Genderen, Maria M., Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Child Health, Moekotte, Lude, Kuiper, Jonas J.W., Hiddingh, Sanne, Nguyen, Xuan Thanh An, Boon, Camiel J.F., van den Born, L. Ingeborgh, de Boer, Joke H., and van Genderen, Maria M.

Published
2023

10. Association of Risk Variants in the CFH Gene With Elevated Levels of Coagulation and Complement Factors in Idiopathic Multifocal Choroiditis

Author

MS Oogheelkunde, Infection & Immunity, Neurogenetica, CTI Eijkelkamp, de Groot, Evianne L., Ossewaarde-van Norel, Jeannette, de Boer, Joke H., Hiddingh, Sanne, Bakker, Bjorn, van Huet, Ramon A.C., Ten Dam-van Loon, Ninette H., Thiadens, Alberta A.H.J., Meester-Smoor, Magda A., de Jong-Hesse, Yvonne, Los, Leonoor I., den Hollander, Anneke I., Boon, Camiel J.F., Kiemeney, Lambertus A., van Eijk, Kristel R., Bakker, Mark K., Hoyng, Carel B., Kuiper, Jonas J.W., MS Oogheelkunde, Infection & Immunity, Neurogenetica, CTI Eijkelkamp, de Groot, Evianne L., Ossewaarde-van Norel, Jeannette, de Boer, Joke H., Hiddingh, Sanne, Bakker, Bjorn, van Huet, Ramon A.C., Ten Dam-van Loon, Ninette H., Thiadens, Alberta A.H.J., Meester-Smoor, Magda A., de Jong-Hesse, Yvonne, Los, Leonoor I., den Hollander, Anneke I., Boon, Camiel J.F., Kiemeney, Lambertus A., van Eijk, Kristel R., Bakker, Mark K., Hoyng, Carel B., and Kuiper, Jonas J.W.

Published
2023

12. Systems genomics in age-related macular degeneration

Author

den Hollander, Anneke I., primary, Mullins, Robert F., additional, Orozco, Luz D., additional, Voigt, Andrew P., additional, Chen, Hsu-Hsin, additional, Strunz, Tobias, additional, Grassmann, Felix, additional, Haines, Jonathan L., additional, Kuiper, Jonas J.W., additional, Tumminia, Santa J., additional, Allikmets, Rando, additional, Hageman, Gregory S., additional, Stambolian, Dwight, additional, Klaver, Caroline C.W., additional, Boeke, Jef D., additional, Chen, Hao, additional, Honigberg, Lee, additional, Katti, Suresh, additional, Frazer, Kelly A., additional, Weber, Bernhard H.F., additional, and Gorin, Michael B., additional

Published
2022
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14. Systems genomics in age-related macular degeneration

Author

den Hollander, Anneke I., Mullins, Robert F., Orozco, Luz D., Voigt, Andrew P., Chen, Hsu Hsin, Strunz, Tobias, Grassmann, Felix, Haines, Jonathan L., Kuiper, Jonas J.W., Tumminia, Santa J., Allikmets, Rando, Hageman, Gregory S., Stambolian, Dwight, Klaver, Caroline C.W., Boeke, Jef D., Chen, Hao, Honigberg, Lee, Katti, Suresh, Frazer, Kelly A., Weber, Bernhard H.F., Gorin, Michael B., den Hollander, Anneke I., Mullins, Robert F., Orozco, Luz D., Voigt, Andrew P., Chen, Hsu Hsin, Strunz, Tobias, Grassmann, Felix, Haines, Jonathan L., Kuiper, Jonas J.W., Tumminia, Santa J., Allikmets, Rando, Hageman, Gregory S., Stambolian, Dwight, Klaver, Caroline C.W., Boeke, Jef D., Chen, Hao, Honigberg, Lee, Katti, Suresh, Frazer, Kelly A., Weber, Bernhard H.F., and Gorin, Michael B.

Abstract

Genomic studies in age-related macular degeneration (AMD) have identified genetic variants that account for the majority of AMD risk. An important next step is to understand the functional consequences and downstream effects of the identified AMD-associated genetic variants. Instrumental for this next step are ‘omics’ technologies, which enable high-throughput characterization and quantification of biological molecules, and subsequent integration of genomics with these omics datasets, a field referred to as systems genomics. Single cell sequencing studies of the retina and choroid demonstrated that the majority of candidate AMD genes identified through genomic studies are expressed in non-neuronal cells, such as the retinal pigment epithelium (RPE), glia, myeloid and choroidal cells, highlighting that many different retinal and choroidal cell types contribute to the pathogenesis of AMD. Expression quantitative trait locus (eQTL) studies in retinal tissue have identified putative causal genes by demonstrating a genetic overlap between gene regulation and AMD risk. Linking genetic data to complement measurements in the systemic circulation has aided in understanding the effect of AMD-associated genetic variants in the complement system, and supports that protein QTL (pQTL) studies in plasma or serum samples may aid in understanding the effect of genetic variants and pinpointing causal genes in AMD. A recent epigenomic study fine-mapped AMD causal variants by determing regulatory regions in RPE cells differentiated from induced pluripotent stem cells (iPSC-RPE). Another approach that is being employed to pinpoint causal AMD genes is to produce synthetic DNA assemblons representing risk and protective haplotypes, which are then delivered to cellular or animal model systems. Pinpointing causal genes and understanding disease mechanisms is crucial for the next step towards clinical translation. Clinical trials targeting proteins encoded by the AMD-associated genomic lo

Published
2022

15. A Blood Protein Signature Stratifies Clinical Response to csDMARD Therapy in Pediatric Uveitis

Author

Oogheelkunde Onderzoek, CTI Luminex, MS Oogheelkunde, Infection & Immunity, CTI Bont, Wennink, Roos A.W., Ayuso, Viera Kalinina, Tao, Weiyang, Delemarre, Eveline M., de Boer, Joke H., Kuiper, Jonas J.W., Oogheelkunde Onderzoek, CTI Luminex, MS Oogheelkunde, Infection & Immunity, CTI Bont, Wennink, Roos A.W., Ayuso, Viera Kalinina, Tao, Weiyang, Delemarre, Eveline M., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2022

17. A serum protein network predicts the need for systemic immunomodulatory therapy in autoimmune uveitis

Author

Kuiper, Jonas J.W., primary, Verhagen, Fleurieke H., additional, Hiddingh, Sanne, additional, Wennink, Roos A.W., additional, Hansen, Anna M., additional, Casey, Kerry A., additional, Haitjema, Saskia, additional, Hoefer, Imo E., additional, Yakin, Mehmet, additional, Sen, Nida, additional, Radstake, Timothy R.D.J., additional, and de Boer, Joke H., additional

Published
2021
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18. A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

Author

Kuiper, Jonas J.W., Van Setten, Jessica, Ripke, Stephan, Van ‘T Slot, Ruben, Mulder, Flip, Missotten, Tom, Baarsma, G. Seerp, Francioli, Laurent C., Pulit, Sara L., De Kovel, Carolien G.F., Ten Dam-Van Loon, Ninette, Den Hollander, Anneke I., Huis het Veld, Paulien, Hoyng, Carel B., Cordero-Coma, Miguel, Martín, Javier, Llorenç, Victor, Arya, Bharti, Thomas, Dhanes, Bakker, Steven C., Ophoff, Roel A., Rothova, Aniki, De Bakker, Paul I.W., Mutis, Tuna, and Koeleman, Bobby P.C.

Published
2014
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19. Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

Author

Oogheelkunde Onderzoek, Translationele immunologie, Infection & Immunity, MS Oogheelkunde, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Regenerative Medicine and Stem Cells, CTI Van Loosdregt, Immuno/reuma onderzoek 5 (Vastert2), Wennink, Roos A.W., Pandit, Aridaman, Haasnoot, Anne Mieke J.W., Hiddingh, Sanne, Kalinina Ayuso, Viera, Wulffraat, Nico M., Vastert, Bas J., Radstake, Timothy R.D.J., de Boer, Joke H., Kuiper, Jonas J.W., Oogheelkunde Onderzoek, Translationele immunologie, Infection & Immunity, MS Oogheelkunde, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Regenerative Medicine and Stem Cells, CTI Van Loosdregt, Immuno/reuma onderzoek 5 (Vastert2), Wennink, Roos A.W., Pandit, Aridaman, Haasnoot, Anne Mieke J.W., Hiddingh, Sanne, Kalinina Ayuso, Viera, Wulffraat, Nico M., Vastert, Bas J., Radstake, Timothy R.D.J., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2020

20. cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation

Author

Oogheelkunde Onderzoek, Infection & Immunity, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Laban, Kamil G., Rijken, Rianne, Hiddingh, Sanne, Mertens, Jorre S., van der Veen, Rob L.P., Eenhorst, Christine A.E., Pandit, Aridaman, Radstake, Timothy R.D.J., de Boer, Joke H., Kalmann, Rachel, Kuiper, Jonas J.W., Oogheelkunde Onderzoek, Infection & Immunity, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Laban, Kamil G., Rijken, Rianne, Hiddingh, Sanne, Mertens, Jorre S., van der Veen, Rob L.P., Eenhorst, Christine A.E., Pandit, Aridaman, Radstake, Timothy R.D.J., de Boer, Joke H., Kalmann, Rachel, and Kuiper, Jonas J.W.

Published
2020

21. A pan-inflammatory microRNA-cluster is associated with orbital non-Hodgkin lymphoma and idiopathic orbital inflammation

Author

Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Other research (not in main researchprogram), Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, CDL Arcadia, Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P.J., Hiddingh, Sanne, van der Veen, Rob L.P., Eenhorst, Christine A.E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F.A., Haitjema, Saskia, de Groot, Mark C.H., Radstake, Timothy R.D.J., de Boer, Joke H., Kuiper, Jonas J.W., Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Other research (not in main researchprogram), Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, CDL Arcadia, Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P.J., Hiddingh, Sanne, van der Veen, Rob L.P., Eenhorst, Christine A.E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F.A., Haitjema, Saskia, de Groot, Mark C.H., Radstake, Timothy R.D.J., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2020

22. Aqueous Humor Analysis Identifies Higher Branched Chain Amino Acid Metabolism as a Marker for Human Leukocyte Antigen-B27 Acute Anterior Uveitis and Disease Activity

Author

Verhagen, Fleurieke H., Stigter, Edwin C.A., Pras-Raves, Mia L., Burgering, Boudewijn M.T., Imhof, Saskia M., Radstake, Timothy R.D.J., de Boer, Joke H., Kuiper, Jonas J.W., Verhagen, Fleurieke H., Stigter, Edwin C.A., Pras-Raves, Mia L., Burgering, Boudewijn M.T., Imhof, Saskia M., Radstake, Timothy R.D.J., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2019

25. Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome

Author

Other research (not in main researchprogram), UMC Utrecht, Guasp, Pablo, Lorente, Elena, Martín-Esteban, Adrian, Barnea, Eilon, Romania, Paolo, Fruci, Doriana, Kuiper, Jonas J.W., Admon, Arie, López de Castro, José A., Other research (not in main researchprogram), UMC Utrecht, Guasp, Pablo, Lorente, Elena, Martín-Esteban, Adrian, Barnea, Eilon, Romania, Paolo, Fruci, Doriana, Kuiper, Jonas J.W., Admon, Arie, and López de Castro, José A.

Published
2019

26. Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas

Author

MS Oogheelkunde, UMC Utrecht, Infection & Immunity, Other research (not in main researchprogram), CTI Radstake, Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, Wisse, Robert P.L., Kuiper, Jonas J.W., Radstake, Timothy R.D., Broen, Jasper C.A., MS Oogheelkunde, UMC Utrecht, Infection & Immunity, Other research (not in main researchprogram), CTI Radstake, Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, Wisse, Robert P.L., Kuiper, Jonas J.W., Radstake, Timothy R.D., and Broen, Jasper C.A.

Published
2019

27. Aqueous Humor Analysis Identifies Higher Branched Chain Amino Acid Metabolism as a Marker for Human Leukocyte Antigen-B27 Acute Anterior Uveitis and Disease Activity

Author

Polisecretariaat Oogheelkunde, Infection & Immunity, CMM Groep Burgering, Cancer, Genetica Sectie Metabole Diagnostiek, CMM Sectie Molecular Cancer Research, Translationele immunologie, Other research (not in main researchprogram), Verhagen, Fleurieke H., Stigter, Edwin C.A., Pras-Raves, Mia L., Burgering, Boudewijn M.T., Imhof, Saskia M., Radstake, Timothy R.D.J., de Boer, Joke H., Kuiper, Jonas J.W., Polisecretariaat Oogheelkunde, Infection & Immunity, CMM Groep Burgering, Cancer, Genetica Sectie Metabole Diagnostiek, CMM Sectie Molecular Cancer Research, Translationele immunologie, Other research (not in main researchprogram), Verhagen, Fleurieke H., Stigter, Edwin C.A., Pras-Raves, Mia L., Burgering, Boudewijn M.T., Imhof, Saskia M., Radstake, Timothy R.D.J., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2019

30. Identification of an Amino Acid Motif in HLA–DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis

Author

Haasnoot, Anne Mieke J.W., Schilham, Marco W., Kamphuis, Sylvia, Hissink Muller, Petra C.E., Heiligenhaus, Arnd, Foell, Dirk, Minden, Kirsten, Ophoff, Roel A., Radstake, Timothy R.D.J., Den Hollander, Anneke I., Reinards, Tjitske H.C.M., Hiddingh, Sanne, Schalij-Delfos, Nicoline E., Hoppenreijs, Esther P.A.H., van Rossum, Marion A.J., Wouters, Carine, Saurenmann, Rotraud K., van den Berg, J. Merlijn, Wulffraat, Nico M., ten Cate, Rebecca, de Boer, Joke H., Pulit, Sara L., Kuiper, Jonas J.W., ICON-JIA Study Group, Haasnoot, Anne Mieke J.W., Schilham, Marco W., Kamphuis, Sylvia, Hissink Muller, Petra C.E., Heiligenhaus, Arnd, Foell, Dirk, Minden, Kirsten, Ophoff, Roel A., Radstake, Timothy R.D.J., Den Hollander, Anneke I., Reinards, Tjitske H.C.M., Hiddingh, Sanne, Schalij-Delfos, Nicoline E., Hoppenreijs, Esther P.A.H., van Rossum, Marion A.J., Wouters, Carine, Saurenmann, Rotraud K., van den Berg, J. Merlijn, Wulffraat, Nico M., ten Cate, Rebecca, de Boer, Joke H., Pulit, Sara L., Kuiper, Jonas J.W., and ICON-JIA Study Group

Published
2018

31. Potential Diagnosis of Vitreoretinal Lymphoma by Detection of MYD88 Mutation in Aqueous Humor with Ultrasensitive Droplet Digital Polymerase Chain Reaction

Author

Hiemcke-Jiwa, Laura S., Ten Dam-Van Loon, Ninette H., Leguit, Roos J., Nierkens, Stefan, Ossewaarde-Van Norel, Jeannette, De Boer, Joke H., Roholl, Floor F., De Weger, Roel A., Huibers, Manon M.H., De Groot-Mijnes, Jolanda D.F., Kuiper, Jonas J.W., Hiemcke-Jiwa, Laura S., Ten Dam-Van Loon, Ninette H., Leguit, Roos J., Nierkens, Stefan, Ossewaarde-Van Norel, Jeannette, De Boer, Joke H., Roholl, Floor F., De Weger, Roel A., Huibers, Manon M.H., De Groot-Mijnes, Jolanda D.F., and Kuiper, Jonas J.W.

Published
2018

32. High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis

Author

Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

33. A disease-associated microRNA cluster links inflammatory pathways and an altered composition of leukocyte subsets to noninfectious uveitis

Author

Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

34. Potential Diagnosis of Vitreoretinal Lymphoma by Detection of MYD88 Mutation in Aqueous Humor with Ultrasensitive Droplet Digital Polymerase Chain Reaction

Author

Pathologie Opleiding, Zorgeenheid Oogheelkunde Zorg, MS Oogheelkunde, Infection & Immunity, Pathologie Pathologen staf, Cancer, CDL Patiëntenzorg MI, Pathologie Laboratorium diagnostiek, Circulatory Health, MMB Infectiepreventie, Other research (not in main researchprogram), Hiemcke-Jiwa, Laura S., Ten Dam-Van Loon, Ninette H., Leguit, Roos J., Nierkens, Stefan, Ossewaarde-Van Norel, Jeannette, De Boer, Joke H., Roholl, Floor F., De Weger, Roel A., Huibers, Manon M.H., De Groot-Mijnes, Jolanda D.F., Kuiper, Jonas J.W., Pathologie Opleiding, Zorgeenheid Oogheelkunde Zorg, MS Oogheelkunde, Infection & Immunity, Pathologie Pathologen staf, Cancer, CDL Patiëntenzorg MI, Pathologie Laboratorium diagnostiek, Circulatory Health, MMB Infectiepreventie, Other research (not in main researchprogram), Hiemcke-Jiwa, Laura S., Ten Dam-Van Loon, Ninette H., Leguit, Roos J., Nierkens, Stefan, Ossewaarde-Van Norel, Jeannette, De Boer, Joke H., Roholl, Floor F., De Weger, Roel A., Huibers, Manon M.H., De Groot-Mijnes, Jolanda D.F., and Kuiper, Jonas J.W.

Published
2018

35. High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis

Author

MS Oogheelkunde, Infection & Immunity, Translationele immunologie, CDL Patiëntenzorg MI, Other research (not in main researchprogram), Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., MS Oogheelkunde, Infection & Immunity, Translationele immunologie, CDL Patiëntenzorg MI, Other research (not in main researchprogram), Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

36. A disease-associated microRNA cluster links inflammatory pathways and an altered composition of leukocyte subsets to noninfectious uveitis

Author

Planning en Opnamebureau, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., Planning en Opnamebureau, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

38. Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis

Author

Kuiper, Jonas J.W., primary, van Setten, Jessica, additional, Devall, Matthew, additional, Cretu-Stancu, Mircea, additional, Hiddingh, Sanne, additional, Ophoff, Roel A., additional, Missotten, Tom O.A.R., additional, van Velthoven, Mirjam, additional, Den Hollander, Anneke I, additional, Hoyng, Carel B, additional, James, Edward, additional, Reeves, Emma, additional, Cordero-Coma, Miguel, additional, Fonollosa, Alejandro, additional, Adán, Alfredo, additional, Martín, Javier, additional, Koeleman, Bobby P.C., additional, de Boer, Joke H., additional, Pulit, Sara L., additional, Márquez, Ana, additional, and Radstake, Timothy R. D. J., additional

Published
2018
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39. Electrolyte composition of retro-oil fluid and silicone oil-related visual loss

Author

Oogheelkunde Onderzoek, Infection & Immunity, Zorgeenheid Oogheelkunde Medisch, Other research (not in main researchprogram), MS Oogheelkunde, Scheerlinck, Laura M.E., Kuiper, Jonas J.W., Liem, Albert T.A., Schellekens, Peter A.W.J.F., van Leeuwen, Redmer, Oogheelkunde Onderzoek, Infection & Immunity, Zorgeenheid Oogheelkunde Medisch, Other research (not in main researchprogram), MS Oogheelkunde, Scheerlinck, Laura M.E., Kuiper, Jonas J.W., Liem, Albert T.A., Schellekens, Peter A.W.J.F., and van Leeuwen, Redmer

Published
2016

42. Detection of choroid- and retina-antigen reactive CD8+ and CD4+ T lymphocytes in the vitreous fluid of patients with birdshot chorioretinopathy.

Author

Kuiper, Jonas J.W., Rothova, Aniki, Schellekens, Peter A.W., Ossewaarde-van Norel, Annette, Bloem, Andries C., and Mutis, Tuna

Subjects
*CD8 antigen, *CD4 antigen, *T cells, *VITREOUS body, *UVEITIS, *HLA histocompatibility antigens, *PATIENTS
Abstract

Abstract: Birdshot chorioretinopathy (BSCR), a progressive form of non-infectious uveitis, is the strongest HLA-associated disease described to date, with >95% of the patients displaying HLA-A29. Since indirect evidence indicates the involvement of T cells in the etiopathology of the disease, we now isolated, cultured and analyzed the vitreous fluid-infiltrating T cells from two BSCR patients with respect to their phenotype, cytokine profile, clonal distribution and antigen specificity. Phenotypic analyses revealed the predominant presence of both CD4+ and CD8+ T cells in vitreous fluid. Further analyses on short term expanded and cloned T cells suggested that eye-infiltrating T cells generally displayed a Th1 like cytokine profile with secretion of high levels of IFN-γ and TNF-α. In one patient an oligoclonal CD4+ and CD8+ T cell infiltration, with a moderate to strongly skewed TCR Vβ usage was suggestive for an antigen driven infiltration/expansion. Indeed, a number of intraocular CD4+ and CD8+ T cells responded to crude retinal and choroidal lysates. These results, which demonstrate for the first time the existence of eye-antigen-specific T cells in the vitreous fluid of BSCR patients, substantiate the current view on the role of eye-antigen specific T cells in the etiopathology of BSCR. [Copyright &y& Elsevier]

Published
2014
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