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2. PEGylation of Phosphatidylglycerol/Docosahexaenoic Acid Hexosomes with d-α-Tocopheryl Succinate Poly(ethylene glycol)

Author

Gizem, Bor, Jen-Hao, Lin, Kui-Yu, Lin, Hung-Chih, Chen, Ray Putra, Prajnamitra, Stefan, Salentinig, Patrick C H, Hsieh, Seyed Moein, Moghimi, and Anan, Yaghmur

Subjects
Mice, Docosahexaenoic Acids, alpha-Tocopherol, Humans, Animals, Nanoparticles, Phosphatidylglycerols, Tissue Distribution, Succinates, Polyethylene Glycols
Abstract

Considering the broad therapeutic potential of omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), here we study the effect of PEGylation of DHA-incorporated hexosomes on their physicochemical characteristics and biodistribution following intravenous injection into mice. Hexosomes were formed from phosphatidylglycerol and DHA with a weight ratio of 3:2. PEGylation was achieved through the incorporation of either d-α-tocopheryl succinate poly(ethylene glycol)

Published
2022

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