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9 results on '"Kuhn Samantha"'

1. Antibody Screening Results for Anti-Nucleocapsid Antibodies Toward the Development of a Lateral Flow Assay to Detect SARS-CoV-2 Nucleocapsid Protein

Author

Cate, David M., primary, Bishop, Joshua D., additional, Hsieh, Helen V., additional, Glukhova, Veronika A., additional, Alonzo, Luis F., additional, Hermansky, H. Gleda, additional, Barrios-Lopez, Brianda, additional, Grant, Benjamin D., additional, Anderson, Caitlin E., additional, Spencer, Ethan, additional, Kuhn, Samantha, additional, Gallagher, Ryan, additional, Rivera, Rafael, additional, Bennett, Crissa, additional, Byrnes, Samantha A., additional, Connelly, John T., additional, Dewan, Puneet K., additional, Boyle, David S., additional, Weigl, Bernhard H., additional, and Nichols, Kevin P., additional

Published
2021
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2. Screening Antibodies Raised against the Spike Glycoprotein of SARS-CoV-2 to Support the Development of Rapid Antigen Assays

Author

Cantera, Jason L., primary, Cate, David M., additional, Golden, Allison, additional, Peck, Roger B., additional, Lillis, Lorraine L., additional, Domingo, Gonzalo J., additional, Murphy, Eileen, additional, Barnhart, Bryan C., additional, Anderson, Caitlin A., additional, Alonzo, Luis F., additional, Glukhova, Veronika, additional, Hermansky, Gleda, additional, Barrios-Lopez, Brianda, additional, Spencer, Ethan, additional, Kuhn, Samantha, additional, Islam, Zeba, additional, Grant, Benjamin D., additional, Kraft, Lucas, additional, Herve, Karine, additional, de Puyraimond, Valentine, additional, Hwang, Yuri, additional, Dewan, Puneet K., additional, Weigl, Bernhard H., additional, Nichols, Kevin P., additional, and Boyle, David S., additional

Published
2021
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3. Antibody Screening Results for Anti-Nucleocapsid Antibodies Towards the Development of a SARS-CoV-2 Nucleocapsid Protein Antigen Detecting Lateral Flow Assay

Author

Kuhn Samantha, Bishop Joshua D, Nichols Kevin P, Byrnes Sam A, Spencer Ethan, Glukhova Veronika, Weigl Bernhard H, Cate David, Rivera Rafael, Hermansky H Gleda, Hsieh Helen, Anderson Caitlin E, Dewan Puneet K, Connelly John T, S. Boyle David, Barrios-Lopez Brianda, Gallagher Ryan, Bennett Crissa, and Grant Ben D

Subjects
Antigen, Coronavirus disease 2019 (COVID-19), biology, Chemistry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), biology.protein, Protein antigen, Antibody, Antibody screening, Virology, Epitope, Lateral flow immunoassay
Abstract

The global COVID-19 pandemic has created an urgent demand for accurate rapid point of care diagnostic tests. Antigen-based assays are suitably inexpensive and can be rapidly mass-produced, but sufficiently accurate performance requires highly-optimized antibodies and assay conditions. An automated liquid handling system, customized to handle lateral flow immunoassay (LFA) arrays, was used for high-throughput antibody screening of anti-nucleocapsid antibodies that will perform optimally on an LFA. Six hundred seventy-three anti-nucleocapsid antibody pairs were tested as both capture and detection reagents with the goal of finding those pairs that have the greatest affinity for unique epitopes of the nucleocapsid protein of SARS-CoV-2 while also performing optimally in an LFA format. In contrast to traditional antibody screening methods (e.g. ELISA, bio-layer interferometry), the methods described here integrate real-time LFA reaction kinetics and binding directly on nitrocellulose. We have identified several candidate antibody pairs that are suitable for further development of an LFA for SARS-CoV-2.

Published
2020
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4. Antibody Screening Results for Anti-Nucleocapsid Antibodies Towards the Development of a SARS-CoV-2 Nucleocapsid Protein Antigen Detecting Lateral Flow Assay

Author

Cate, David, primary, Hsieh, Helen, primary, Glukhova, Veronika, primary, Bishop, Joshua D, primary, Hermansky, H Gleda, primary, Barrios-Lopez, Brianda, primary, Grant, Ben D, primary, Anderson, Caitlin E, primary, Spencer, Ethan, primary, Kuhn, Samantha, primary, Gallagher, Ryan, primary, Rivera, Rafael, primary, Bennett, Crissa, primary, Byrnes, Sam A, primary, Connelly, John T, primary, Dewan, Puneet K, primary, S. Boyle, David, primary, Weigl, Bernhard H, primary, and Nichols, Kevin P, primary

Published
2021
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5. Screening Antibodies Raised Against the Spike Glycoprotein of SARS-CoV-2 to Support the Development of Rapid Antigen Assays

Author

Cantera, Jason, primary, Cate, David, additional, Golden, Allison, additional, Peck, Roger, additional, Lillis, Lorraine, additional, Domingo, Gonzalo, additional, Murphy, Eileen, additional, Barnhart, Bryan, additional, Anderson, Caitlin E, additional, Alonzo, Luis F, additional, Glukhova, Veronika, additional, Hermansky, Gleda, additional, Barrios-Lopez, Brianda, additional, Spencer, Ethan, additional, Kuhn, Samantha, additional, Islam, Zeba, additional, Grant, Benjamin, additional, Kraft, Lucas, additional, Herve, Karine, additional, de Puyraimond, Valentine, additional, Hwang, Yuri, additional, Dewan, Puneet K, additional, Weigl, Bernhard H, additional, Nichols, Kevin P, additional, and Boyle, David, additional

Published
2020
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6. Antibody Screening Results for Anti-Nucleocapsid Antibodies Towards the Development of a SARS-CoV-2 Nucleocapsid Protein Antigen Detecting Lateral Flow Assay

Author

Cate, David, primary, Hsieh, Helen, additional, Glukhova, Veronika, additional, Bishop, Joshua D, additional, Hermansky, H Gleda, additional, Barrios-Lopez, Brianda, additional, Grant, Ben D, additional, Anderson, Caitlin E, additional, Spencer, Ethan, additional, Kuhn, Samantha, additional, Gallagher, Ryan, additional, Rivera, Rafael, additional, Bennett, Crissa, additional, Byrnes, Sam A, additional, Connelly, John T, additional, Dewan, Puneet K, additional, S. Boyle, David, additional, Weigl, Bernhard H, additional, and Nichols, Kevin P, additional

Published
2020
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8. Optimization of Nurse Staffing under Varying Preferences.

Author

Millard, Derek, Mesmer, Bryan, Gholston, Sampson, and Kuhn, Samantha

Subjects
HOSPITAL emergency services, HEALTH services administration, NURSES
Abstract

Staff scheduling in hospital emergency departments is challenging due to the uncertainty involved in the work needed to be performed, the high impact if the work is not performed, and the non-traditional working hours. Also, the desires of the stakeholder on what should be optimized may not be clear. This paper addresses the impacts of preferences in the staffing of emergency department nurses. The research uses data collected from a local hospital on patient flow to model nurse staffing. This model is used in an optimization framework where objective functions and constraints are varied to determine their impact on scheduling. Value models of patient care and wasted funds, as well as four constraints are explored in this research. The research concludes that understanding and representing the stakeholder's preference properly is critical in determining an optimal schedule. [ABSTRACT FROM AUTHOR]

Published
2018

9. Costume Design and Production for The Mystery of Edwin Drood by Rupert Holmes

Author

Kuhn, Samantha Anne

Subjects
Theater
Abstract

The purpose of this paper is to document the costume design and production process for Rupert Holmes’ musical The Mystery of Edwin Drood, as produced by the Department of Theatre and the School of Music at The Ohio State University and directed by A. Scott Parry, the School of Music’s Director of Lyric Theatre. The musical was presented in the Thurber Theatre at Ohio State, November 7 through November 11, 2012.The Mystery of Edwin Drood is a musical in which a Victorian Music Hall troupe in 1892 England performs a dramatization of Charles Dickens’ final, unfinished novel, The Mystery of Edwin Drood. Told in the vaudevillian manner of English Music Hall Theatre of the late nineteenth century, the piece utilizes song, dance, bawdy humor and audience participation to tell and ultimately discover an ending to Dickens’ story. Research and designs for the production were derived from photographs, historical research and artwork of Music Hall performers and everyday English citizens from the late nineteenth century. The scenic design transformed the Thurber Theatre into a nineteenth century Music Hall, necessitating that the costume design also transform the actors into Victorian performers to support the historical demands of the script and to create an authentic experience for the audience. The lighting design aided the melodramatic nature of the piece and the sound was all produced live, as it would have been in the 1890’s.

Published
2013

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