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6. How prevalent is a cancer-protective lifestyle? Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations in Switzerland.

Author

Karavasiloglou, Nena, Pestoni, Giulia, Pannen, Sarah Theresa, Schönenberger, Katja Angela, Kuhn, Tilman, and Rohrmann, Sabine

Subjects
TUMOR prevention, LIFESTYLES, CROSS-sectional method, RISK assessment, SOCIOECONOMIC factors, RESEARCH funding, DESCRIPTIVE statistics, TUMORS, LOGISTIC regression analysis
Abstract

Population monitoring of lifestyle behaviours that are crucial as risk and protective factors for major chronic diseases is vital for the identification of priority areas for public health. In this study, we aimed to investigate the prevalence of adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations in Switzerland, overall and by selected sociodemographic and lifestyle characteristics. Data from the population-based, cross-sectional survey menuCH were used. We constructed a score reflecting adherence to the 2018 WCRF/AICR cancer prevention recommendations. Multinomial logistic regression models were fitted to investigate the association of sociodemographic and lifestyle characteristics with the level of adherence to the WCRF/AICR cancer prevention recommendations. The least frequently met cancer prevention recommendations were the ones on fibre intake (met by 13·7 %), red and processed meat (25·4 %), and ultra-processed food (33·3 %) consumption, while the recommendation on physical activity was met by almost 80 %. Women and individuals with tertiary education were more likely to have a score of ≥ 5 (as a reflection of adherence to the cancer prevention recommendations), compared with men or those who completed secondary education, respectively. Current smokers were less likely to have a score of ≥ 5, compared with never smokers. A high proportion of the population in Switzerland was found to not adhere closely to the WCRF/AICR cancer prevention recommendations. Differences were detected based on sociodemographic characteristics. Education and policy actions are needed to facilitate the adoption of a cancer-protective lifestyle. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

Author

Karavasiloglou, Nena, primary, Hughes, David J., additional, Murphy, Neil, additional, Schomburg, Lutz, additional, Sun, Qian, additional, Seher, Vartiter, additional, Rohrmann, Sabine, additional, Weiderpass, Elisabete, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Mancini, Francesca Romana, additional, Mahamat-Saleh, Yahya, additional, Kaaks, Rudolf, additional, Kuhn, Tilman, additional, Schulze, Matthias B., additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Sacerdote, Carlotta, additional, Derksen, Jeroen W.G., additional, Skeie, Guri, additional, Hjartåker, Anette, additional, Lasheras, Cristina, additional, Agudo, Antonio, additional, Sánchez, Maria-José, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Van Guelpen, Bethany, additional, Gylling, Björn, additional, Bradbury, Kathryn E., additional, Papier, Keren, additional, Freisling, Heinz, additional, Aglago, Elom K., additional, Cross, Amanda J., additional, Riboli, Elio, additional, Aune, Dagfinn, additional, Gunter, Marc J., additional, and Jenab, Mazda, additional

Published
2022
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11. Estimating the Level of Asymptomatic COVID-19 Infections in Northern Ireland in 2020

Author

Hall, Peter A., Kiss, Gabor, Kuhn, Tilman, Moutari, Salissou, Patterson, Ellen, and Smith, Emily

Subjects
SDG 3 - Good Health and Well-being, General Medicine
Abstract

The identification and understanding of COVID-19 potential routes of transmission are fundamental to informing policies and strategies to successfully control the outbreak. Various studies highlighted asymptomatic infections as one of the silent drivers of the epidemic. An accurate estimation of the asymptomatic cases and the understanding of their contribution to the spread of the disease could enhance the effectiveness of current control strategies, mainly based on the symptom onset, to curb transmission. We investigate the dynamics of the COVID-19 epidemic in Northern Ireland during the period 1st March 25th to December 2020 to estimate the proportion of the asymptomatic infections in the country. We extended our previous model to include the stage of the asymptomatic infection, and we implement the corresponding deterministic model using a publicly available dataset. We partition the data into 11 sets over the period of study and fit the model parameters on the consecutive intervals using the cumulative number of confirmed positive cases for each interval. Moreover, we assess numerically the impacts of uncertainty in testing and we provide estimates of the reproduction numbers using the fitted parameters. We found that the proportion of asymptomatically infectious subpopulations, in Northern Ireland during the period of study, ranged between 5% and 25% of exposed individuals. Also, the estimate of the basic reproduction number, R0, is 3.3089. The lower and upper estimates for herd immunity are (0.6181, 0.7243) suggesting that around 70% of the population of Northern Ireland should acquire immunity via infection or vaccination, which is in line with estimates reported in other studies.

Published
2022

12. Gebäudeintegrierte Solartechnik

Author

Krippner, Roland, primary, Becker, Gerd, additional, Maslaton, Martin, additional, Maurer, Christoph, additional, Kuhn, Tilman E., additional, Kämpfen, Beat, additional, Reinberg, Georg W., additional, Reyelts, Hinrich, additional, Haselhuhn, Ralf, additional, and Hemmerle, Claudia, additional

Published
2016
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13. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts.

Author

Karavasiloglou, Nena, Hughes, David J., Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B., Tumino, Rosario, Panico, Salvatore, and Masala, Giovanna

Subjects
CONFIDENCE intervals, TISSUE banks, META-analysis, COLON (Anatomy), MULTIVARIATE analysis, COLORECTAL cancer, RESEARCH funding, CALCIUM, DIETARY calcium, LOGISTIC regression analysis, ODDS ratio, LONGITUDINAL method, DISEASE risk factors
Abstract

Background: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk. Objectives: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies. Methods: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts. Results: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum. Conclusions: In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Author

Bamia, Christina, Lagiou, Pagona, Jenab, Mazda, Trichopoulou, Antonia, Fedirko, Veronika, Aleksandrova, Krasimira, Pischon, Tobias, Overvad, Kim, Olsen, Anja, Tjnneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Kuhn, Tilman, Boeing, Heiner, Floegel, Anna, Benetou, Vasiliki, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. B(as), Dik, Vincent K., Bhoo-Pathy, Nirmala, Uiterwaal, Cuno S. P. M., Weiderpass, Elisabete, Lund, Eiliv, Quirós, Ramón J., Zamora-Ros, Raul, Molina-Montes, Esther, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Björn, Wallström, Peter, Nilsson, Lena Maria, Sund, Malin, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Travis, Ruth C., Ferrari, Pietro, Duarte-Salles, Talita, Stepien, Magdalena, Gunter, Marc, Murphy, Neil, Riboli, Elio, and Trichopoulos, Dimitrios

Published
2015
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17. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author

Huyghe, Jeroen R. Harrison, Tabitha A. Bien, Stephanie A. and Hampel, Heather Figueiredo, Jane C. Schmit, Stephanie L. and Conti, V, David Chen, Sai Qu, Conghui Lin, Yi Barfield, Richard Baron, John A. Cross, Amanda J. Diergaarde, Brenda and Duggan, David Harlid, Sophia Imaz, Liher Kang, Hyun Min and Levine, David M. Perduca, Vittorio Perez-Cornago, Aurora and Sakoda, Lori C. Schumacher, Fredrick R. Slattery, Martha L. and Toland, Amanda E. van Duijnhoven, Franzel J. B. Van Guelpen, Bethany Agudo, Antonio Albanes, Demetrius Alonso, M. Henar and Anderson, Kristin Arnau-Collell, Coral Arndt, Volker and Banbury, Barbara L. Bassik, Michael C. Berndt, I, Sonja and Bezieau, Stephane Bishop, D. Timothy Boehm, Juergen Boeing, Heiner Boutron-Ruault, Marie-Christine Brenner, Hermann and Brezina, Stefanie Buch, Stephan Buchanan, Daniel D. and Burnett-Hartman, Andrea Caan, Bette J. Campbell, Peter T. and Carr, Prudence R. Castells, Antoni Castellvi-Bel, Sergi and Chan, Andrew T. Chang-Claude, Jenny Chanock, Stephen J. and Curtis, Keith R. de la Chapelle, Albert Easton, Douglas F. and English, Dallas R. Feskens, Edith J. M. Gala, Manish and Gallinger, Steven J. Gauderman, W. James Giles, Graham G. and Goodman, Phyllis J. Grady, William M. Grove, John S. Gsur, Andrea Gunter, Marc J. Haile, Robert W. Hampe, Jochen and Hoffmeister, Michael Hopper, John L. Hsu, Wan-Ling Huang, Wen-Yi Hudson, Thomas J. Jenab, Mazda Jenkins, Mark A. and Joshi, Amit D. Keku, Temitope O. Kooperberg, Charles Kuhn, Tilman Kury, Sebastien Le Marchand, Loic Lejbkowicz, Flavio and Li, I, Christopher Li, Li Lieb, Wolfgang Lindblom, Annika Lindor, Noralane M. Mannisto, Satu Markowitz, Sanford D. Milne, Roger L. Moreno, Lorena Murphy, Neil Nassir, Rami Offit, Kenneth Ogino, Shuji Panico, Salvatore and Parfrey, Patrick S. Pearlman, Rachel Pharoah, Paul D. P. and Phipps, I, Amanda Platz, Elizabeth A. Potter, John D. and Prentice, Ross L. Qi, Lihong Raskin, Leon Rennert, Gad and Rennert, Hedy S. Riboli, Elio Schafmayer, Clemens Schoen, Robert E. Seminara, Daniela Song, Mingyang Su, Yu-Ru and Tangen, Catherine M. Thibodeau, Stephen N. Thomas, Duncan C. and Trichopoulou, Antonia Ulrich, Cornelia M. Visvanathan, Kala and Vodicka, Pavel Vodickova, Ludmila Vymetalkova, Veronika and Weigl, Korbinian Weinstein, Stephanie J. White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Abecasis, Goncalo R. and Nickerson, Deborah A. Scacheri, Peter C. Kundaje, Anshul and Casey, Graham Gruber, Stephen B. Hsu, Li Moreno, Victor and Hayes, Richard B. Newcomb, Polly A. Peters, Ulrike

Subjects
digestive system diseases
Abstract

Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined. Design To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling. Results We identified 13 loci that reached genome-wide significance (p

Published
2021

18. Tea and coffee consumption and risk of esophageal cancer: The European prospective investigation into cancer and nutrition study

Author

Zamora-Ros, Raul, Luján-Barroso, Leila, Bueno-de-Mesquita, H. B(as), Dik, Vincent K., Boeing, Heiner, Steffen, Annika, Tjnneland, Anne, Olsen, Anja, Bech, Bodil Hammer, Overvad, Kim, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuhn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Tumino, Rosario, Panico, Salvatore, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Weiderpass, Elisabete, Skeie, Guri, Huerta, José María, Sánchez, María-José, Argüelles, Marcial, Amiano, Pilar, Ardanaz, Eva, Nilsson, Lena, Wallner, Bengt, Lindkvist, Björn, Wallström, Peter, Peeters, Petra H.M., Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Freisling, Heinz, Stepien, Magdalena, Ferrari, Pietro, Gunter, Marc J., Murphy, Neil, Riboli, Elio, and González, Carlos A.

Published
2014
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19. Diabetes und Krebs: Epidemiologische Zusammenhänge und biologische Mechanismen

Author

Katzke, Verena A, Kaaks, Rudolf, Kneisel, Jutta, and Kuhn, Tilman

Subjects
SDG 3 - Good Health and Well-being
Abstract

The results from experimental and epidemiologic studies suggest higher risks for certain gynaecological and gastrointestinal cancers in persons with diabetes. The strongest associations between diabetes and cancer risk have been observed for individuals with type 2 diabetes, while similar tendencies have been reported with respect to prediabetes, gestational diabetes and type 1 diabetes. In addition to other obesity-related mechanisms such as chronic inflammation, an upregulated insulin–IGF1 axis (IGF: insulin-like growth factor) and hyperglycaemia may underlie such associations. Data from cohort studies indicating lower cancer risks under metformin vs. insulin therapy have to be interpreted with caution, and randomized trials on potential anticancer effects of metformin among cancer patients with and without diabetes are ongoing. Generally, lifestyle interventions and successful drug therapy in early phases of diabetes development are considered as important means of cancer prevention.

Published
2020

22. Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a 1 case-control study nested within a European prospective cohort

Author

Aglago, Elom K., Rinaldi, Sabina, Freisling, Heinz, Jiao, Li, Hughes, David J., Fedirko, Veronika, Schalkwijk, Casper C, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Eriksen, Anne Kirstine, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Kuhn, Tilman, Schulze, Matthias B., Krasimira, Aleksandrova, Masala, Giovanna, Krogh, Vittorio, Panico, Salavatore, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, Bas, van Gils, Carla H., Sandanger, Torkjel M, Gram, Inger Torhild, Skeie, Guri, Quiros, J. Ramon, Jakszyn, Rachel, Sanchez, Maria-Jose, Amiano, Pilar, Huerta, Jose Maria, Ardanaz, Eva, Johansson, Ingegerd, Harlid, Sophia, Perez-Cornago, Aurora, Mayén, Ana-Lucia, Cordova, Reynalda, Gunter, Marc J., Vineis, Paolo, Cross, Amanda J., Riboli, Elio, and Jenab, Mazda

Subjects
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762
Abstract

Background: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. Methods: To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case–control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively. Results: Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59–1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42–0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68–1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82–0.99). Conclusions: Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk. Impact: Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development.

Published
2020

24. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author

Huyghe, Jeroen R, primary, Harrison, Tabitha A, additional, Bien, Stephanie A, additional, Hampel, Heather, additional, Figueiredo, Jane C, additional, Schmit, Stephanie L, additional, Conti, David V, additional, Chen, Sai, additional, Qu, Conghui, additional, Lin, Yi, additional, Barfield, Richard, additional, Baron, John A, additional, Cross, Amanda J, additional, Diergaarde, Brenda, additional, Duggan, David, additional, Harlid, Sophia, additional, Imaz, Liher, additional, Kang, Hyun Min, additional, Levine, David M, additional, Perduca, Vittorio, additional, Perez-Cornago, Aurora, additional, Sakoda, Lori C, additional, Schumacher, Fredrick R, additional, Slattery, Martha L, additional, Toland, Amanda E, additional, van Duijnhoven, Franzel JB, additional, Van Guelpen, Bethany, additional, Arndt, Volker, additional, Agudo, Antonio, additional, Albanes, Demetrius, additional, Alonso, M Henar, additional, Anderson, Kristin, additional, Arnau-Collell, Coral, additional, Banbury, Barbara, additional, Bassik, Michael C, additional, Berndt, Sonja I, additional, Bézieau, Stéphane, additional, Bishop, D Timothy, additional, Boehm, Juergen, additional, Boeing, Heiner, additional, Boutron-Ruault, Marie-Christine, additional, Brenner, Hermann, additional, Brezina, Stefanie, additional, Buch, Stephan, additional, Buchanan, Daniel D, additional, Burnett-Hartman, Andrea, additional, Caan, Bette J, additional, Campbell, Peter T, additional, Carr, Prudence, additional, Castells, Antoni, additional, Castellví-Bel, Sergi, additional, Chan, Andrew T, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J, additional, Curtis, Keith R, additional, de la Chapelle, Albert, additional, Easton, Douglas F, additional, English, Dallas R, additional, Feskens, Edith JM, additional, Gala, Manish, additional, Gallinger, Steven J, additional, Gauderman, W James, additional, Giles, Graham G, additional, Goodman, Phyllis J, additional, Grady, William M, additional, Grove, John S, additional, Gsur, Andrea, additional, Gunter, Marc J, additional, Haile, Robert W, additional, Hampe, Jochen, additional, Hoffmeister, Michael, additional, Hopper, John L, additional, Hsu, Wan-Ling, additional, Huang, Wen-Yi, additional, Hudson, Thomas J, additional, Jenab, Mazda, additional, Jenkins, Mark A, additional, Joshi, Amit D, additional, Keku, Temitope O, additional, Kooperberg, Charles, additional, Kuhn, Tilman, additional, Küry, Sébastien, additional, Le Marchand, Loic, additional, Lejbkowicz, Flavio, additional, Li, Christopher I, additional, Li, Li, additional, Lieb, Wolfgang, additional, Lindblom, Annika, additional, Lindor, Noralane M, additional, Männistö, Satu, additional, Markowitz, Sanford D, additional, Milne, Roger L, additional, Moreno, Lorena, additional, Murphy, Neil, additional, Nassir, Rami, additional, Offit, Kenneth, additional, Ogino, Shuji, additional, Panico, Salvatore, additional, Parfrey, Patrick S, additional, Pearlman, Rachel, additional, Pharoah, Paul D P, additional, Phipps, Amanda I, additional, Platz, Elizabeth A, additional, Potter, John D, additional, Prentice, Ross L, additional, Qi, Lihong, additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S, additional, Riboli, Elio, additional, Schafmayer, Clemens, additional, Schoen, Robert E, additional, Seminara, Daniela, additional, Song, Mingyang, additional, Su, Yu-Ru, additional, Tangen, Catherine M, additional, Thibodeau, Stephen N, additional, Thomas, Duncan C, additional, Trichopoulou, Antonia, additional, Ulrich, Cornelia M, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Vymetalkova, Veronika, additional, Weigl, Korbinian, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O, additional, Wu, Anna H, additional, Abecasis, Goncalo R, additional, Nickerson, Deborah A, additional, Scacheri, Peter C, additional, Kundaje, Anshul, additional, Casey, Graham, additional, Gruber, Stephen B, additional, Hsu, Li, additional, Moreno, Victor, additional, Hayes, Richard B, additional, Newcomb, Polly A, additional, and Peters, Ulrike, additional

Published
2020
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27. Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort

Author

Assi, Nada Gunter, Marc J. Thomas, Duncan C. Leitzmann, Michael Stepien, Magdalena Chajes, Veronique Philip, Thierry and Vineis, Paolo Bamia, Christina Boutron-Ruault, Marie-Christine Sandanger, Torkjel M. Molinuevo, Amaia and Boshuizen, Hendriek Sundkvist, Anneli Kuhn, Tilman Travis, Ruth Overvad, Kim Riboli, Elio Scalbert, Augustin Jenab, Mazda Viallon, Vivian Ferrari, Pietro

Abstract

Background: Studies using metabolomic data have identified metabolites from several compound classes that are associated with disease-related lifestyle factors. Objective: In this study, we identified metabolic signatures reflecting lifestyle patterns and related them to the risk of hepatocellular carcinoma (HCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Design: Within a nested case-control study of 147 incident HCC cases and 147 matched controls, partial least squares (PLS) analysis related 7 modified healthy lifestyle index (HLI) variables (diet, BMI, physical activity, lifetime alcohol, smoking, diabetes, and hepatitis) to 132 targeted serum-measured metabolites and a liver function score. The association between the resulting PLS scores and HCC risk was examined in multivariable conditional logistic regression models, where ORs and 95% CIs were computed. Results: The lifestyle component’s PLS score was negatively associated with lifetime alcohol, BMI, smoking, and diabetes, and positively associated with physical activity. Its metabolic counterpart was positively related to the metabolites sphingomyelin (SM)(OH) C14: 1, C16: 1, and C22: 2 and negatively related to glutamate, hexoses, and the diacyl-phosphatidylcholine PC aaC32: 1. The lifestyle and metabolomics components were inversely associated with HCC risk, with the ORs for a 1-SD increase in scores equal to 0.53 (95% CI: 0.38, 0.74) and 0.28 (0.18, 0.43), and the associated AUCs equal to 0.64 (0.57, 0.70) and 0.74 (0.69, 0.80), respectively. Conclusions: This study identified a metabolic signature reflecting a healthy lifestyle pattern which was inversely associated with HCC risk. The metabolic profile displayed a stronger association with HCC than did the modified HLI derived from questionnaire data. Measuring a specific panel of metabolites may identify strata of the population at higher risk for HCC and can add substantial discrimination compared with questionnaire data.

Published
2018

28. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study

Author

Fedirko, Veronika Hao Quang Tran Gewirtz, Andrew T. Stepien, Magdalena Trichopoulou, Antonia Aleksandrova, Krasimira and Olsen, Anja Tjonneland, Anne Overvad, Kim Carbonnel, Franck and Boutron-Ruault, Marie-Christine Severi, Gianluca Kuhn, Tilman Kaaks, Rudolf Boeing, Heiner Bamia, Christina and Lagiou, Pagona Grioni, Sara Panico, Salvatore Palli, Domenico Tumino, Rosario Naccarati, Alessio Peeters, Petra H. Bueno-de-Mesquita, H. B. Weiderpass, Elisabete Castano, Jose Maria Huerta Barricarte, Aurelio Sanchez, Maria-Jose and Dorronsoro, Miren Quiros, J. Ramon Agudo, Antonio Sjoberg, Klas Ohlsson, Bodil Hemmingsson, Oskar Werner, Marten and Bradbury, Kathryn E. Khaw, Kay-Tee Wareham, Nick Tsilidis, Konstantinos K. Aune, Dagfinn Scalbert, Augustin Romieu, Isabelle Riboli, Elio Jenab, Mazda

Abstract

Background: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking. Methods: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression. Results: Antibody response to LPS and flagellin was associated with a statistically significant increase in the risk of hepatocellular carcinoma (highest vs. lowest quartile: RR = 11.76, 95% confidence interval = 1.70-81.40; P-trend = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses. Conclusions: These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted.

Published
2017

31. Tea and coffee consumption and risk of esophageal cancer:the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Luján-Barroso, Leila, Bueno-de-Mesquita, H Bas, Dik, Vincent K, Boeing, Heiner, Steffen, Annika, Tjønneland, Anne, Olsen, Anja Viendahl, Bech, Bodil Hammer, Overvad, Kim, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuhn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Tumino, Rosario, Panico, Salvatore, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Weiderpass, Elisabete, Skeie, Guri, Huerta, José María, Sánchez, María-José, Argüelles, Marcial, Amiano, Pilar, Ardanaz, Eva, Nilsson, Lena, Wallner, Bengt, Lindkvist, Björn, Wallström, Peter, Peeters, Petra H M, Key, Timothy J, Khaw, Kay-Thee, Wareham, Nicholas J, Freisling, Heinz, Stepien, Magdalena, Ferrari, Pietro, Gunter, Marc J, Murphy, Neil, Riboli, Elio, and González, Carlos A

Abstract

Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; P-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; P-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; P-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases. © 2014 Wiley Periodicals, Inc.

Published
2014

32. Tea and coffee consumption and risk of esophageal cancer: The European prospective investigation into cancer and nutrition study

Author

Zamora-Ros, Raul Lujan-Barroso, Leila Bueno-de-Mesquita, H. B(as) Dik, Vincent K. Boeing, Heiner Steffen, Annika and Tjonneland, Anne Olsen, Anja Bech, Bodil Hammer Overvad, Kim and Boutron-Ruault, Marie-Christine Racine, Antoine Fagherazzi, Guy Kuhn, Tilman Katzke, Verena Trichopoulou, Antonia and Lagiou, Pagona Trichopoulos, Dimitrios Tumino, Rosario and Panico, Salvatore Vineis, Paolo Grioni, Sara Palli, Domenico and Weiderpass, Elisabete Skeie, Guri Maria Huerta, Jose and Sanchez, Maria-Jose Argueelles, Marcial Amiano, Pilar and Ardanaz, Eva Nilsson, Lena Wallner, Bengt Lindkvist, Bjorn and Wallstrom, Peter Peeters, Petra H. M. Key, Timothy J. and Khaw, Kay-Thee Wareham, Nicholas J. Freisling, Heinz and Stepien, Magdalena Ferrari, Pietro Gunter, Marc J. Murphy, Neil Riboli, Elio Gonzalez, Carlos A.

Abstract

Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition. Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; p-trend = 0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; p-trend = 0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; p-trend = 0.011). However, no statistically significant findings were observed using the continuous variable (per 100 mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases.

Published
2014

33. Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Author

Fages, Anne, primary, Duarte-Salles, Talita, additional, Stepien, Magdalena, additional, Ferrari, Pietro, additional, Fedirko, Veronika, additional, Pontoizeau, Clément, additional, Trichopoulou, Antonia, additional, Aleksandrova, Krasimira, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Kuhn, Tilman, additional, Floegel, Anna, additional, Boeing, Heiner, additional, Lagiou, Pagona, additional, Bamia, Christina, additional, Trichopoulos, Dimitrios, additional, Palli, Domenico, additional, Pala, Valeria, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H., additional, Weiderpass, Elisabete, additional, Agudo, Antonio, additional, Molina-Montes, Esther, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Sjöberg, Klas, additional, Ohlsson, Bodil, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Travis, Ruth C., additional, Schmidt, Julie A., additional, Cross, Amanda, additional, Gunter, Marc, additional, Riboli, Elio, additional, Scalbert, Augustin, additional, Romieu, Isabelle, additional, Elena-Herrmann, Benedicte, additional, and Jenab, Mazda, additional

Published
2015
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34. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Author

Bamia, Christina, primary, Lagiou, Pagona, additional, Jenab, Mazda, additional, Trichopoulou, Antonia, additional, Fedirko, Veronika, additional, Aleksandrova, Krasimira, additional, Pischon, Tobias, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Fagherazzi, Guy, additional, Racine, Antoine, additional, Kuhn, Tilman, additional, Boeing, Heiner, additional, Floegel, Anna, additional, Benetou, Vasiliki, additional, Palli, Domenico, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Bueno-de-Mesquita, H.Bas, additional, Dik, Vincent K., additional, Bhoo-Pathy, Nirmala, additional, Uiterwaal, Cuno S. P. M., additional, Weiderpass, Elisabete, additional, Lund, Eiliv, additional, Quirós, J. Ramón, additional, Zamora-Ros, Raul, additional, Molina-Montes, Esther, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Lindkvist, Björn, additional, Wallström, Peter, additional, Nilsson, Lena Maria, additional, Sund, Malin, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Bradbury, Kathryn E., additional, Travis, Ruth C., additional, Ferrari, Pietro, additional, Duarte-Salles, Talita, additional, Stepien, Magdalena, additional, Gunter, Marc, additional, Murphy, Neil, additional, Riboli, Elio, additional, and Trichopoulos, Dimitrios, additional

Published
2014
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35. Implementation of a new bi-directional solar modelling method for complex facades within the ESP-r building simulation program

Author

Frontini, Francesco, Kuhn, Tilman E., Heikel, Sebastian, Strachan, Paul, and Kokogiannakis, Georgios

Subjects
TJ
Abstract

This paper provides an overview of a new method for modelling the total solar energy transmittance. It is implemented in the ESP-r building simulation program to model complex façades such as double glazed façades with external, internal or integrated shading devices. This new model has been validated and tested for several cases. The new model required changes to the solar control simulation algorithm and the user interface, so a new “Advanced optics menu” was also introduced into ESP-r. The paper presents the interface development and application of the new technique to different simulation configurations (especially different complex façades with shading devices) in a standard office building.

Published
2009

37. Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort.

Author

Bakker, Marije F., Peeters, Petra H. M., Klaasen, Veronique M., Bueno-de-Mesquita, H. Bas, Jansen, Eugene H. J. M., Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie-Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, and Kuhn, Tilman

Subjects
SMOKING, BREAST tumor risk factors, AGE factors in disease, DIET therapy for cancer patients, CAROTENOIDS, CONFIDENCE intervals, STATISTICAL correlation, ALCOHOL drinking, LONGITUDINAL method, LYCOPENE, MEDICAL cooperation, PROBABILITY theory, RESEARCH, RESEARCH funding, STATISTICAL hypothesis testing, STATISTICS, T-test (Statistics), VITAMIN A, VITAMIN C, VITAMIN E, WOMEN'S health, LOGISTIC regression analysis, DATA analysis, BODY mass index, CASE-control method, PHYSICAL activity, HORMONE-dependent tumors, DATA analysis software, DESCRIPTIVE statistics, ZEAXANTHIN, LUTEIN, ODDS ratio
Abstract

Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. Objective: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. Design: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER2) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for α-carotene, β-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin, retinol, α-tocopherol, γ-tocopherol, and vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided. Results: In quintile 5 compared with quintile 1, α-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and β-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER2 breast tumors. The other analytes were not statistically associated with ER2 breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER2 and ER+ tumors was statistically significant only for β-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER2/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution). Conclusion: Our results indicate that higher concentrations of plasma β-carotene and α-carotene are associated with lower breast cancer risk of ER2 tumors. [ABSTRACT FROM AUTHOR]

Published
2016
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38. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition.

Author

Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-de-Mesquita, H. Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kuhn, Tilman, Tsironis, Christos, and Papatesta, Eleni-Maria

Subjects
IRON metabolism, LIVER injuries, SMOKING, HEPATOCELLULAR carcinoma, ANTHROPOMETRY, ASPARTATE aminotransferase, BILIRUBIN, BIOMARKERS, DIET therapy for cancer patients, COFFEE, CONFIDENCE intervals, DOSE-response relationship in biochemistry, ALCOHOL drinking, ENZYMES, FATTY liver, HEPATITIS, INFLAMMATION, INGESTION, INTERLEUKINS, LONGITUDINAL method, METABOLISM, MULTIVARIATE analysis, NOSOLOGY, NUTRITIONAL assessment, PROBABILITY theory, REGRESSION analysis, RESEARCH evaluation, RESEARCH funding, STATISTICAL hypothesis testing, STATISTICS, T-test (Statistics), LOGISTIC regression analysis, DATA analysis, STATISTICAL significance, ALANINE aminotransferase, RELATIVE medical risk, CASE-control method, DATA analysis software, DESCRIPTIVE statistics, DISEASE risk factors
Abstract

Background: Higher coffee intake has been purportedly related to a lower risk of liver cancer. However, it remains unclear whether this association may be accounted for by specific biological mechanisms. Objective: We aimed to evaluate the potential mediating roles of inflammatory, metabolic, liver injury, and iron metabolism biomarkers on the association between coffee intake and the primary form of liver cancer--hepatocellular carcinoma (HCC). Design: We conducted a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition among 125 incident HCC cases matched to 250 controls using an incidence-density sampling procedure. The association of coffee intake with HCC risk was evaluated by using multivariable-adjusted conditional logistic regression that accounted for smoking, alcohol consumption, hepatitis infection, and other established liver cancer risk factors. The mediating effects of 21 biomarkers were evaluated on the basis of percentage changes and associated 95% CIs in the estimated regression coefficients of models with and without adjustment for biomarkers individually and in combination. Results: The multivariable-adjusted RR of having ≥4 cups (600 mL) coffee/d compared with,2 cups (300 mL)/d was 0.25 (95% CI: 0.11, 0.62; P-trend = 0.006). A statistically significant attenuation of the association between coffee intake and HCC risk and thereby suspected mediation was confirmed for the inflammatory biomarker IL-6 and for the biomarkers of hepatocellular injury glutamate dehydrogenase, alanine aminotransferase, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and total bilirubin, which--in combination--attenuated the regression coefficients by 72% (95% CI: 7%, 239%). Of the investigated biomarkers, IL-6, AST, and GGT produced the highest change in the regression coefficients: 40%, 56%, and 60%, respectively. Conclusion: These data suggest that the inverse association of coffee intake with HCC risk was partly accounted for by biomarkers of inflammation and hepatocellular injury. [ABSTRACT FROM AUTHOR]

Published
2015
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39. Energieoptimierte Beleuchtung bei gleichzeitiger Verbesserung der Lebensqualität durch Nutzung von Tageslicht und neuer Lampen‐ und Vorschalttechnik

Author

Kaase, Heinrich, primary, Aydınlı, Sırrı, additional, Gramm, Stefan, additional, Thiel, Stefan, additional, de Boer, Jan, additional, Erhorn, Hans, additional, Kuhn, Tilman, additional, Wienold, Jan, additional, Hillmann, Gustav, additional, Korolkow, Margarethe, additional, and Piazena, Helmut, additional

Published
2012
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41. The gut microbiome modulates associations between adherence to a Mediterranean-style diet, abdominal adiposity, and C-reactive protein in population-level analysis

Author

Jennings, Amy, Kuhn, Tilman, Bondonno, Nicola P., Waniek, Sabina, Bang, Corinna, Franke, Andre, Kassubek, Jan, Müller, Hans-Peter, Both, Marcus, Weber, Katharina S., Lieb, Wolfgang, and Cassidy, Aedín

Abstract

Adherence to a Mediterranean-style dietary pattern is likely to have variable effects on body composition, but the impact of gut microbiome on this relationship is unknown.

Published
2023
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43. Additional file 1: of Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Author

Fages, Anne, Talita Duarte-Salles, Stepien, Magdalena, Ferrari, Pietro, Fedirko, Veronika, Pontoizeau, Clément, Trichopoulou, Antonia, Aleksandrova, Krasimira, Tjønneland, Anne, Olsen, Anja, Clavel-Chapelon, Françoise, Marie-Christine Boutron-Ruault, Severi, Gianluca, Kaaks, Rudolf, Kuhn, Tilman, Floegel, Anna, Boeing, Heiner, Lagiou, Pagona, Bamia, Christina, Trichopoulos, Dimitrios, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, H. Bueno-De-Mesquita, Peeters, Petra, Weiderpass, Elisabete, Agudo, Antonio, Molina-Montes, Esther, Huerta, José, Ardanaz, Eva, Dorronsoro, Miren, Sjöberg, Klas, Ohlsson, Bodil, Kay-Tee Khaw, Wareham, Nick, Travis, Ruth, Schmidt, Julie, Cross, Amanda, Gunter, Marc, Riboli, Elio, Scalbert, Augustin, Romieu, Isabelle, Elena-Herrmann, Benedicte, and Mazda Jenab

Subjects
3. Good health
Abstract

Supplementary methods for NMR metabolomics data acquisition, additional table (Table S1. Metabolites identified in serum samples) and additional figures (Figure S1. Validation (1000 resampling) of the O-PLS model based on 1H CPMG spectra and O-PLS metabolic signature obtained from the analysis of 1H NOESY NMR spectra. Figure S2. Validation (1000 resampling) of the O-PLS models stratified by hepatitis infection status of the cases, and liver function score. Figure S3. Validation (1000 resampling) of the O-PLS models stratified by lag time between blood collection and diagnosis). (PDF 684 kb)

44. Additional file 1: of Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Author

Fages, Anne, Talita Duarte-Salles, Stepien, Magdalena, Ferrari, Pietro, Fedirko, Veronika, Pontoizeau, Clément, Trichopoulou, Antonia, Aleksandrova, Krasimira, Tjønneland, Anne, Olsen, Anja, Clavel-Chapelon, Françoise, Marie-Christine Boutron-Ruault, Severi, Gianluca, Kaaks, Rudolf, Kuhn, Tilman, Floegel, Anna, Boeing, Heiner, Lagiou, Pagona, Bamia, Christina, Trichopoulos, Dimitrios, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, H. Bueno-De-Mesquita, Peeters, Petra, Weiderpass, Elisabete, Agudo, Antonio, Molina-Montes, Esther, Huerta, José, Ardanaz, Eva, Dorronsoro, Miren, Sjöberg, Klas, Ohlsson, Bodil, Kay-Tee Khaw, Wareham, Nick, Travis, Ruth, Schmidt, Julie, Cross, Amanda, Gunter, Marc, Riboli, Elio, Scalbert, Augustin, Romieu, Isabelle, Elena-Herrmann, Benedicte, and Mazda Jenab

Subjects
3. Good health
Abstract

Supplementary methods for NMR metabolomics data acquisition, additional table (Table S1. Metabolites identified in serum samples) and additional figures (Figure S1. Validation (1000 resampling) of the O-PLS model based on 1H CPMG spectra and O-PLS metabolic signature obtained from the analysis of 1H NOESY NMR spectra. Figure S2. Validation (1000 resampling) of the O-PLS models stratified by hepatitis infection status of the cases, and liver function score. Figure S3. Validation (1000 resampling) of the O-PLS models stratified by lag time between blood collection and diagnosis). (PDF 684 kb)

45. Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study

Author

Ricci, Cristian, Wood, Angela, Muller, David, Gunter, Marc J, Agudo, Antonio, Boeing, Heiner, van der Schouw, Yvonne T, Warnakula, Samantha, Saieva, Calogero, Spijkerman, Annemieke, Sluijs, Ivonne, Tjønneland, Anne, Kyrø, Cecilie, Weiderpass, Elisabete, Kuhn, Tilman, Kaaks, Rudolf, Sánchez, Maria-Jose, Panico, Salvatore, Agnoli, Claudia, Palli, Domenico, Tumino, Rosario, Engstrom, Gunnar, Melander, Olle, Bonnet, Fabrice, Boer, Jolanda M A, Key, Timothy J, Travis, Ruth C, Overvad, Kim, Verschuren, W M Monique, Quiráóós, J Ramáón, Trichopoulou, Antonia, Papatesta, Eleni-Maria, Peppa, Eleni, Iribas, Conchi Moreno, Gavrila, Diana, Forslund, Ann-Sofie, Jansson, Jan-Háóóåkan, Matullo, Giuseppe, Arriola, Larraitz, Freisling, Heinz, Lassale, Camille, Tzoulaki, Ioanna, Sharp, Stephen J, Forouhi, Nita G, Langenberg, Claudia, Saracci, Rodolfo, Sweeting, Michael, Brennan, Paul, Butterworth, Adam S, Riboli, Elio, Wareham, Nick J, Danesh, John, and Ferrari, Pietro

Abstract

ObjectiveTo investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke.DesignMulticentre case-cohort study.SettingA study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries.Participants32 549 participants without baseline CVD, comprised of incident CVD cases and a subcohort for comparison.Main outcome measuresNon-fatal and fatal CHD and stroke (including ischaemic and haemorrhagic stroke).ResultsThere were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated with non-fatal CHD, with a hazard ratio of 0.94 (95% confidence interval 0.92 to 0.96) per 12 g/day higher intake. There was a J shaped association between baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and 0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake, respectively, compared with 0.1-4.9 g/day. In contrast, hazard ratios for non-fatal and fatal stroke risk were 1.04 (1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day increase in baseline alcohol intake, respectively, including broadly similar findings for ischaemic and haemorrhagic stroke. Associations with cardiovascular outcomes were broadly similar with average lifetime alcohol consumption as for baseline alcohol intake, and across the eight countries studied. There was no strong evidence for interactions of alcohol consumption with smoking status on the risk of CVD events.ConclusionsAlcohol intake was inversely associated with non-fatal CHD risk but positively associated with the risk of different stroke subtypes. This highlights the opposing associations of alcohol intake with different CVD types and strengthens the evidence for policies to reduce alcohol consumption.

Published
2018
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46. Added value of serum hormone measurements in risk prediction models for breast cancer for women not using exogenous hormones: Results from the EPIC cohort

Author

Tilman Kühn, Anika Hüsing, Pilar Amiano, Rosario Tumino, Ruth C. Travis, Kay-Tee Khaw, Antonio Agudo, Kim Overvad, Ioanna Tzoulaki, Philippos Orfanos, H. Bas Bueno de Mesquita, Petra H.M. Peeters, Giovanna Masala, Kuanrong Li, Agnès Fournier, Vassiliki Benetou, Elio Riboli, J. Ramón Quirós, Anja Olsen, Salvatore Panico, Gianluca Severi, Valeria Pala, Pietro Ferrari, Francesca Fasanelli, Antonia Trichopoulou, Rudolf Kaaks, Melissa A. Merritt, Carla H. Van Gills, Anne Tjønneland, Laure Dossus, María José Sánchez, René T. Fortner, Maria Dolores Chirlaque, Aurelio Barricarte, Marie-Christine Boutron-Ruault, Heiner Boeing, University Medical Center Utrecht, Husing, Anika, Fortner, Renee T, Kuhn, Tilman, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Boutron Ruault, Marie Christine, Severi, Gianluca, Fournier, Agne, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, Orfanos, Philippo, Masala, Giovanna, Pala, Valeria, Tumino, Rosario, Fasanelli, Francesca, Panico, Salvatore, Bueno de Mesquita, H. Ba, Peeters, Petra, van Gils, Carla H, Quiros, J. Ramon, Agudo, Antonio, Sanchez, Maria Jose, Chirlaque, Maria Dolore, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay Tee, Travis, Ruth C, Dossus, Laure, Li, Kuanrong, Ferrari, Pietro, Merritt, Melissa A, Tzoulaki, Ioanna, Riboli, Elio, and Kaaks, Rudolf

Subjects
Oncology, Cancer Research, PERIOD, 0302 clinical medicine, Sex hormone-binding globulin, Risk Factors, REPRODUCIBILITY, Sex Hormone-Binding Globulin, Testosterone, 030212 general & internal medicine, Insulin-Like Growth Factor I, 10. No inequality, Gonadal Steroid Hormones, Framingham Risk Score, biology, Estradiol, ASSOCIATION, Middle Aged, Prognosis, Postmenopause, POSTMENOPAUSAL WOMEN, PREMENOPAUSAL WOMEN, 030220 oncology & carcinogenesis, Cohort, NUTRITION, Female, Life Sciences & Biomedicine, medicine.medical_specialty, medicine.drug_class, Concordance, Breast Neoplasms, SEX STEROIDS, 03 medical and health sciences, Breast cancer, Internal medicine, medicine, Journal Article, Biomarkers, Tumor, Humans, Oncology & Carcinogenesis, Aged, Gynecology, Science & Technology, business.industry, Case-control study, Cancer, medicine.disease, Prolactin, Insulin-Like Growth Factor Binding Protein 3, Premenopause, Estrogen, Case-Control Studies, biology.protein, business, 1112 Oncology And Carcinogenesis
Abstract

Purpose: Circulating hormone concentrations are associated with breast cancer risk, with well-established associations for postmenopausal women. Biomarkers may represent minimally invasive measures to improve risk prediction models. Experimental Design: We evaluated improvements in discrimination gained by adding serum biomarker concentrations to risk estimates derived from risk prediction models developed by Gail and colleagues and Pfeiffer and colleagues using a nested case–control study within the EPIC cohort, including 1,217 breast cancer cases and 1,976 matched controls. Participants were pre- or postmenopausal at blood collection. Circulating sex steroids, prolactin, insulin-like growth factor (IGF) I, IGF-binding protein 3, and sex hormone–binding globulin (SHBG) were evaluated using backward elimination separately in women pre- and postmenopausal at blood collection. Improvement in discrimination was evaluated as the change in concordance statistic (C-statistic) from a modified Gail or Pfeiffer risk score alone versus models, including the biomarkers and risk score. Internal validation with bootstrapping (1,000-fold) was used to adjust for overfitting. Results: Among women postmenopausal at blood collection, estradiol, testosterone, and SHBG were selected into the prediction models. For breast cancer overall, model discrimination after including biomarkers was 5.3 percentage points higher than the modified Gail model alone, and 3.4 percentage points higher than the Pfeiffer model alone, after accounting for overfitting. Discrimination was more markedly improved for estrogen receptor–positive disease (percentage point change in C-statistic: 7.2, Gail; 4.8, Pfeiffer). We observed no improvement in discrimination among women premenopausal at blood collection. Conclusions: Integration of hormone measurements in clinical risk prediction models may represent a strategy to improve breast cancer risk stratification. Clin Cancer Res; 23(15); 4181–9. ©2017 AACR.

Published
2017

47. Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Author

Amanda J. Cross, Petra H.M. Peeters, Pietro Ferrari, Françoise Clavel-Chapelon, Salvatore Panico, Augustin Scalbert, Anja Olsen, José María Huerta, Paolo Vineis, Gianluca Severi, Eva Ardanaz, H. Bas Bueno-de-Mesquita, Ruth C. Travis, Bénédicte Elena-Herrmann, Nicholas J. Wareham, Pagona Lagiou, Talita Duarte-Salles, Christina Bamia, Anne Tjønneland, Rudolf Kaaks, Bodil Ohlsson, Magdalena Stepien, Antonio Agudo, Krasimira Aleksandrova, Heiner Boeing, Isabelle Romieu, Kay-Tee Khaw, Veronika Fedirko, Domenico Palli, Julie A. Schmidt, Anne Fages, Rosario Tumino, Valeria Pala, Anna Floegel, Dimitrios Trichopoulos, Miren Dorronsoro, Marc J. Gunter, Klas Sjöberg, Clément Pontoizeau, Marie-Christine Boutron-Ruault, Elisabete Weiderpass, Tilman Kühn, Elio Riboli, Mazda Jenab, Antonia Trichopoulou, Esther Molina-Montes, Fages, Anne, Duarte Salles, Talita, Stepien, Magdalena, Ferrari, Pietro, Fedirko, Veronika, Pontoizeau, Clément, Trichopoulou, Antonia, Aleksandrova, Krasimira, Tjønneland, Anne, Olsen, Anja, Clavel Chapelon, Françoise, Boutron Ruault, Marie Christine, Severi, Gianluca, Kaaks, Rudolf, Kuhn, Tilman, Floegel, Anna, Boeing, Heiner, Lagiou, Pagona, Bamia, Christina, Trichopoulos, Dimitrio, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno de Mesquita, H. Ba, Peeters, Petra H, Weiderpass, Elisabete, Agudo, Antonio, Molina Montes, Esther, Huerta, José María, Ardanaz, Eva, Dorronsoro, Miren, Sjöberg, Kla, Ohlsson, Bodil, Khaw, Kay Tee, Wareham, Nick, Travis, Ruth C, Schmidt, Julie A, Cross, Amanda, Gunter, Marc, Riboli, Elio, Scalbert, Augustin, Romieu, Isabelle, Elena Herrmann, Benedicte, Jenab, Mazda, ISA NMR Methods for Metabolism - Methodes RMN en métabolomique (2014-2018), Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), ISA - Centre de RMN à très hauts champs, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), parent, International Agency for Cancer Research (IACR), Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School [Athens], Department of Epidemiology, Deutsches Institut für Ernahrungsforschung Potsdam-Rehbrücke (DIFE), Institute of Cancer Epidemiology, Danish Cancer Society, Department of Food Science [Copenhagen] (UCPH FOOD), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Gustave Roussy (IGR), Human Genetics Foundation (HuGeF), Università degli studi di Torino (UNITO), Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Thermo Fisher Scientific, Thermo Fisher Scientific Inc., German Institute of Human Nutrition Potsdam-Rehbruecke, German Institute of Human Nutrition, Harvard School of Public Health, WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Nutritional Epidemiology Unit, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH)-IRCCS Foundation, Department of Clinical and Experimental Medicine, Università degli studi di Napoli Federico II, Cancer Registry and Histopathology Unit, Civile - M.P.Arezzo Hospital, Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Julius Center for Health Sciences and Primary Care, VU University Medical Center [Amsterdam], Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Department of Community Medicine, University of Tromsø (UiT), Department of Research, Cancer Registry of Norway-Samfundet Folkhälsan, Helsinki, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet [Stockholm], Institut Català d'Oncologia, Spain Institute of Oncology, Andalusian School of Public Health [Granada], Consortium for Biomedical Research in Epidemiology and Public Health, CIBER de Epidemiología y Salud Pública (CIBERESP), Danish Cancer Society Research Center, Murcia Regional Health Council, Sección de Epidemiología de Enfermedades No Transmisibles, Navarre Public Health Institute, Epidemiology and Health Information, Public Health Department of Gipuzkoa, Volvo, VOLVO-VOLVO, Skane University Hospital [Lund], University of Cambridge School of Clinical Medicine, MRC epidemiology Unit, Addenbrooke's Hospital, Cancer Epidemiology Unit, University of Oxford [Oxford], Laboratoire d'informatique Fondamentale de Marseille (LIF), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), School of Public Health [London, UK] (Faculty of Medicine), Imperial College London, Department of Chemistry, University of Cambridge [UK] (CAM), Nutrition and Metabolism Section, Biomarkers Group, Nutrition and Metabolism Section, This work was supported by the French National Cancer Institute (L'Institut National du Cancer, INCA, grant number 2009-139, PI: M. Jenab). AF received financial support (BDI fellowship) from the Centre National de la Recherche Scientifique (CNRS) and Bruker Biospin. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, and Institut National de la Sante et de la Recherche Medicale (INSERM) (France), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ), and Federal Ministry of Education and Research (Germany), Hellenic Health Foundation (Greece), Italian Association for Research on Cancer (AIRC), National Research Council, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, and AIRE-ONLUS Ragusa, AVIS Ragusa, Sicilian Government (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (the Netherlands), European Research Council (ERC, grant number ERC-2009-AdG 232997) and Nordforsk, and Nordic Center of Excellence Programme on Food, Nutrition and Health (Norway), Health Research Fund (FIS), Regional Governments of Andalucia, Asturias, Basque Country, Murcia (No. 6236) and Navarra, and ISCIII RETIC (RD06/0020) (Spain), Swedish Cancer Society, Swedish Scientific Council, and Regional Government of Skane and Vasterbotten (Sweden), Cancer Research UK, Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, and Wellcome Trust (UK). The funders had no role in the study design, data collection, analysis, and interpretation presented in this article. They were neither involved in the writing of the manuscript, nor in the decision to submit it for publication., Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Centre Européen de Résonance Magnétique Nucléaire à Très Hauts Champs (CERMNTHC), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), 'Civile M. P. Arezzo' Hospital, Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), [Fages,A, Pontoizeau,C, Elena-Herrmann,B] Institut des Sciences Analytiques, Centre de RMN à très hauts champs, CNRS/ENS Lyon/UCB Lyon-1, Université de Lyon, Villeurbanne, France. [Duarte-Salles,T, Stepien,M, Ferrari,P, Scalbert,A, Romieu,I, Jenab,M] International Agency for Research on Cancer (IARC-WHO), Lyon, France. [Fedirko,V] Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, USA. [Trichopoulou,A] Hellenic Health Foundation, Athens, Greece. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [Aleksandrova,K, Floegel,A, Boeing,H] Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany. [Tjønneland,A, Olsen,A] Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. [Clavel-Chapelon,F, Boutron-Ruault,M] INSERM, Centre for Research in Epidemiology and Population Health (CESP), nutrition, Hormones and Women’s Health Team, Villejuif, France. Université Paris Sud, Villejuif, France. Institut Gustave Roussy, Villejuif, France. [Severi,G, Vineis,P] Human Genetics Foundation (HuGeF), Torino, Italy. [Kaaks,R, Kuhn,T] Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany. [Lagiou,P, Bamia,C] Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens Medical School, Goudi, Athens, Greece. [Lagiou,P, Trichopoulos,D] Department of Epidemiology, Harvard School of Public Health, Boston, USA. [Palli,D] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy. [Pala,V] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. [Panico,S] Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. [Tumino,R] Cancer Registry and Histopathology Unit, 'Civic - M.P. Arezzo' Hospital, Ragusa, Italy. [Vineis,P, Peeters,PH] MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. [Bueno-de-Mesquita,HB] Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Bueno-de-Mesquita,HB, Cross,A, Gunter,M, RibolI,E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [Peeters,PH] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. [Weiderpass,E] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Samfundet Folkhälsan, Helsinki, Finland. [Agudo,A] Unit of Nutrition and Cancer, IDIBELL, Catalan Institute of Oncology-ICO, L’Hospitalet de Llobregat, Barcelona, Spain. [Molina-Montes,E] Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. [Molina-Montes,E, Huerta,JM, Ardanaz, E] CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Ardanaz,E] Navarre Public Health Institute, Pamplona, Spain. [Dorronsoro,M] Public Health Direction and Biodonostia CIBERESP, Basque Regional Health Department, San Sebastian, Spain. [Sjöberg,K] Department of Clinical Sciences, Lund University, Malmö, Sweden. Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden. [Ohlsson,B] Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö, Sweden. [Khaw,K] University of Cambridge School of Clinical Medicine, Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, UK. [Wareham,N] MRC Epidemiology Unit, University of Cambridge, Cambridge, UK. [Travis,RC, Schmidt,JA] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., This work was supported by the French National Cancer Institute (L’Institut National du Cancer, Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santé et de la Recherche Médicale (INSERM) (France), Health Research Fund (FIS), Regional Governments of Andalucía, Asturias, Basque Country, Murcia (No. 6236) and Navarra, and ISCIII RETIC (RD06/0020) (Spain), Swedish Cancer Society, Swedish Scientific Council, and Regional Government of Skåne and Västerbotten (Sweden), Cancer Research UK, Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, and Wellcome Trust (UK). The funders had no role in the study design, data collection, analysis, and interpretation presented in this article. They were neither involved in the writing of the manuscript, nor in the decision to submit it for publication, Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Torino = University of Turin (UNITO), University of Naples Federico II = Università degli studi di Napoli Federico II, and University of Oxford

Subjects
Oncology, Male, Neoplasias Hepáticas, Cirrhosis, Magnetic Resonance Spectroscopy, Epidemiology, Hepatocellular carcinoma, Nuclear magnetic resonance, Cohort Studies, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Hepatocellular [Medical Subject Headings], 0302 clinical medicine, Risk Factors, Prospective Studies, Prospective cohort study, CIRRHOSIS, Early Detection of Cancer, Medicine(all), 0303 health sciences, Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms [Medical Subject Headings], Liver Neoplasms, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Metabolomics [Medical Subject Headings], Metabolómica, Estudios Prospectivos, General Medicine, Middle Aged, CANCER, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Liver Neoplasm, 030220 oncology & carcinogenesis, Female, Liver cancer, Case-Control Studie, Life Sciences & Biomedicine, Metabolomics, Carcinoma Hepatocelular, Research Article, Human, Adult, medicine.medical_specialty, Carcinoma, Hepatocellular, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], TISSUE METABOLOMICS, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Smoking [Medical Subject Headings], Metabolomic, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [Medical Subject Headings], Càncer de fetge, 03 medical and health sciences, Medicine, General & Internal, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, IDENTIFY SERUM BIOMARKERS, Internal medicine, General & Internal Medicine, medicine, Humans, Obesity, Epidemiologia, 030304 developmental biology, FATTY LIVER-DISEASE, Aged, Hepatitis, Science & Technology, business.industry, Case-control study, METABONOMICS, Cancer, MASS-SPECTROMETRY, medicine.disease, NMR, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings], Prospective Studie, Case-Control Studies, DISCOVERY, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings], Immunology, RISK-FACTORS, Cohort Studie, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer., This work was supported by the French National Cancer Institute (L’Institut National du Cancer; INCA; grant number 2009-139; PI: M. Jenab). AF received financial support (BDI fellowship) from the Centre National de la Recherche Scientifique (CNRS) and Bruker Biospin. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ), and Federal Ministry of Education and Research (Germany); Hellenic Health Foundation (Greece); Italian Association for Research on Cancer (AIRC), National Research Council, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, and AIRE-ONLUS Ragusa, AVIS Ragusa, Sicilian Government (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (the Netherlands); European Research Council (ERC; grant number ERC-2009-AdG 232997) and Nordforsk, and Nordic Center of Excellence Programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), Regional Governments of Andalucía, Asturias, Basque Country, Murcia (No. 6236) and Navarra, and ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Scientific Council, and Regional Government of Skåne and Västerbotten (Sweden); Cancer Research UK, Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, and Wellcome Trust (UK).

Published
2015

48. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population : Multicentre, prospective cohort study

Author

Christina, Bamia, Pagona, Lagiou, Mazda, Jenab, Antonia, Trichopoulou, Veronika, Fedirko, Krasimira, Aleksandrova, Tobias, Pischon, Kim, Overvad, Anja, Olsen, Anne, Tjønneland, Marie-Christine, Boutron-Ruault, Guy, Fagherazzi, Antoine, Racine, Tilman, Kuhn, Heiner, Boeing, Anna, Floegel, Vasiliki, Benetou, Domenico, Palli, Sara, Grioni, Salvatore, Panico, Rosario, Tumino, Paolo, Vineis, H B, Bueno-de-Mesquita, Vincent K, Dik, Nirmala, Bhoo-Pathy, Cuno S P M, Uiterwaal, Elisabete, Weiderpass, Eiliv, Lund, J Ramón, Quirós, Raul, Zamora-Ros, Esther, Molina-Montes, Maria-Dolores, Chirlaque, Eva, Ardanaz, Miren, Dorronsoro, Björn, Lindkvist, Peter, Wallström, Lena Maria, Nilsson, Malin, Sund, Kay-Tee, Khaw, Nick, Wareham, Kathryn E, Bradbury, Ruth C, Travis, Pietro, Ferrari, Talita, Duarte-Salles, Magdalena, Stepien, Marc, Gunter, Neil, Murphy, Elio, Riboli, Dimitrios, Trichopoulos, Bamia, Christina, Lagiou, Pagona, Jenab, Mazda, Trichopoulou, Antonia, Fedirko, Veronika, Aleksandrova, Krasimira, Pischon, Tobia, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, Racine, Antoine, Kuhn, Tilman, Boeing, Heiner, Floegel, Anna, Benetou, Vasiliki, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno de Mesquita, H. B, Dik, Vincent K, Bhoo Pathy, Nirmala, Uiterwaal, Cuno S. P. M, Weiderpass, Elisabete, Lund, Eiliv, Quirós, J. Ramón, Zamora Ros, Raul, Molina Montes, Esther, Chirlaque, Maria Dolore, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Björn, Wallström, Peter, Nilsson, Lena Maria, Sund, Malin, Khaw, Kay Tee, Wareham, Nick, Bradbury, Kathryn E, Travis, Ruth C, Ferrari, Pietro, Duarte Salles, Talita, Stepien, Magdalena, Gunter, Marc, Murphy, Neil, Riboli, Elio, and Trichopoulos, Dimitrios

Subjects
Male, Risk, Carcinoma, Hepatocellular, tea, coffee, Risk Assessment, Article, Beverages, liver cancer, CHRONIC LIVER-DISEASE, DRINKING, Risk Factors, Caffeine, Journal Article, Humans, EPIDEMIOLOGY, Prospective Studies, Beverage, METAANALYSIS, JAPAN, Incidence, Risk Factor, Research Support, Non-U.S. Gov't, Liver Neoplasms, CONSUMPTION, hepatocellular carcinoma, ASSOCIATION, Middle Aged, digestive system diseases, Europe, Multicenter Study, Prospective Studie, Liver Neoplasm, Cardiovascular and Metabolic Diseases, CANCER INCIDENCE, Case-Control Studies, RISK-FACTORS, Female, Case-Control Studie, EPIC, Human, GREEN TEA
Abstract

Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend

Published
2015

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