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2. Phase 3 Randomized Trial of Prophylactic Cranial Irradiation With or Without Hippocampus Avoidance in SCLC (NCT01780675)

Author

Belderbos, José S.A., De Ruysscher, Dirk K.M., De Jaeger, Katrien, Koppe, Friederike, Lambrecht, Maarten L.F., Lievens, Yolande N., Dieleman, Edith M.T., Jaspers, Jaap P.M., Van Meerbeeck, Jan P., Ubbels, Fred, Kwint, Margriet H., Kuenen, Marianne A., Deprez, Sabine, De Ruiter, Michiel B., Boogerd, Willem, Sikorska, Karolina, Van Tinteren, Harm, and Schagen, Sanne B.

Published
2021
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3. Decisional conflict in breast cancer patients considering immediate breast reconstruction

Author

ter Stege, Jacqueline A., Oldenburg, Hester S.A., Woerdeman, Leonie A.E., Witkamp, Arjen J., Kieffer, Jacobien M., van Huizum, Martine A., van Duijnhoven, Frederieke H., Hahn, Daniela E.E., Gerritsma, Miranda A., Kuenen, Marianne A., Kimmings, Nikola (A.N.), Ruhé, Quinten (P.Q.), Krabbe-Timmerman, Irene S., Riet, Martijne van’t, Corten, Eveline M.L., Sherman, Kerry A., and Bleiker, Eveline M.A.

Published
2021
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4. Efficacy of a decision aid in breast cancer patients considering immediate reconstruction: results of a randomized controlled trial

Author

ter Stege, Jacqueline A., primary, Woerdeman, Leonie A.E., additional, Kieffer, Jacobien M., additional, Sherman, Kerry A., additional, Agelink van Rentergem, Joost A., additional, van Duijnhoven, Frederieke H., additional, van Huizum, Martine A., additional, Gerritsma, Miranda A., additional, Kuenen, Marianne, additional, Corten, Eveline M.L., additional, Kimmings, Nikola (A.N.), additional, Ruhé, Quinten (P.Q.), additional, Krabbe-Timmerman, Irene S., additional, van ’t Riet, Martijne, additional, Hahn, Daniela E.E., additional, Witkamp, Arjen J., additional, Oldenburg, Hester S.A., additional, and Bleiker, Eveline M.A., additional

Published
2023
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5. Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance

Author

Konings, Ingrid C.A.W., Harinck, Femme, Kuenen, Marianne A., Sidharta, Grace N., Kieffer, Jacobien M., Aalfs, Cora M., Poley, Jan-Werner, Smets, Ellen M.A., Wagner, Anja, van Rens, Anja, Vleggaar, Frank P., Ausems, Margreet G.E.M., Fockens, Paul, van Hooft, Jeanin E., Bruno, Marco J., Bleiker, Eveline M.A., and On behalf of the Dutch research group on pancreatic cancer surveillance in high-risk individuals

Published
2017
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6. Rapid genetic counseling and testing in newly diagnosed breast cancer: Patients’ and health professionals’ attitudes, experiences, and evaluation of effects on treatment decision making

Author

Wevers, Marijke R., Aaronson, Neil K., Bleiker, Eveline M. A., Hahn, Daniela E. E., Brouwer, Titia, van Dalen, Thijs, Theunissen, Evert B., van Ooijen, Bart, de Roos, Marnix A., Borgstein, Paul J., Vrouenraets, Bart C., Vriens, Eline, Bouma, Wim H., Rijna, Herman, Vente, Johannes P., Kuenen, Marianne A., van der Sanden‐Melis, Jacoline, Witkamp, Arjen J., Rutgers, Emiel J. Th., Verhoef, Senno, and Ausems, Margreet G. E. M.

Published
2017
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7. Reaction on the Interpretation of the Hippocampus Avoidance Prophylactic Cranial Irradiation Trial in SCLC (NCT01780675)

Author

Belderbos, José S.A., De Ruysscher, Dirk K.M., De Jaeger, Katrien, Koppe, Friederike, Lambrecht, Maarten L.F., Lievens, Yolande N., Dieleman, Edith M.T., Jaspers, Jaap P.M., Van Meerbeeck, Jan P., Ubbels, Fred, Kwint, Margriet H., Kuenen, Marianne A., Deprez, Sabine, De Ruiter, Michiel B., Boogerd, Willem, Sikorska, Karolina, Van Tinteren, Harm, and Schagen, Sanne B.

Published
2021
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8. Why Did the Randomized Trial of Prophylactic Cranial Irradiation With or Without Hippocampus Avoidance in SCLC Not Reveal a Difference?

Author

Belderbos, José S.A., De Ruysscher, Dirk K.M., De Jaeger, Katrien, Koppe, Friederike, Lambrecht, Maarten L.F., Lievens, Yolande, Dieleman, Edith M.T., Jaspers, Jaap P.M., Van Meerbeeck, Jan P., Ubbels, Fred, Kwint, Magriet, Kuenen, Marianne, Deprez, Sabine, De Ruiter, Michiel B., Boogerd, Willem, Sikorska, Karolina, Van Tinteren, Harm, and Schagen, Sanne B.

Published
2021
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9. Decisional conflict in breast cancer patients considering immediate breast reconstruction

Author

MS CGO, Cancer, ter Stege, Jacqueline A., Oldenburg, Hester S.A., Woerdeman, Leonie A.E., Witkamp, Arjen J., Kieffer, Jacobien M., van Huizum, Martine A., van Duijnhoven, Frederieke H., Hahn, Daniela E.E., Gerritsma, Miranda A., Kuenen, Marianne A., Kimmings, Nikola (A N.)., Ruhé, Quinten (P Q.)., Krabbe-Timmerman, Irene S., Riet, Martijne van t., Corten, Eveline M.L., Sherman, Kerry A., Bleiker, Eveline M.A., MS CGO, Cancer, ter Stege, Jacqueline A., Oldenburg, Hester S.A., Woerdeman, Leonie A.E., Witkamp, Arjen J., Kieffer, Jacobien M., van Huizum, Martine A., van Duijnhoven, Frederieke H., Hahn, Daniela E.E., Gerritsma, Miranda A., Kuenen, Marianne A., Kimmings, Nikola (A N.)., Ruhé, Quinten (P Q.)., Krabbe-Timmerman, Irene S., Riet, Martijne van t., Corten, Eveline M.L., Sherman, Kerry A., and Bleiker, Eveline M.A.

Published
2021

11. Patient-reported burden of intensified surveillance and surgery in high-risk individuals under pancreatic cancer surveillance

Author

Child Health, Cancer, Genetica Klinische Genetica, MS MDL 1, Overbeek, Kasper A, Cahen, Djuna L, Kamps, Anne, Konings, Ingrid C A W, Harinck, Femme, Kuenen, Marianne A, Koerkamp, Bas Groot, Besselink, Marc G, van Eijck, Casper H, Wagner, Anja, Ausems, Margreet G E, van der Vlugt, Manon, Fockens, Paul, Vleggaar, Frank P, Poley, Jan-Werner, van Hooft, Jeanin E, Bleiker, Eveline M A, Bruno, Marco J, Dutch Familial Pancreatic Cancer Surveillance Study Group, Child Health, Cancer, Genetica Klinische Genetica, MS MDL 1, Overbeek, Kasper A, Cahen, Djuna L, Kamps, Anne, Konings, Ingrid C A W, Harinck, Femme, Kuenen, Marianne A, Koerkamp, Bas Groot, Besselink, Marc G, van Eijck, Casper H, Wagner, Anja, Ausems, Margreet G E, van der Vlugt, Manon, Fockens, Paul, Vleggaar, Frank P, Poley, Jan-Werner, van Hooft, Jeanin E, Bleiker, Eveline M A, Bruno, Marco J, and Dutch Familial Pancreatic Cancer Surveillance Study Group

Published
2020

12. Phase III Randomized Trial of Prophylactic Cranial Irradiation With or Without Hippocampus Avoidance in SCLC

Author

Belderbos, Jose, primary, de Ruysscher, D., additional, de Jaeger, Katrien, additional, Koppe, Friederike, additional, Lambrecht, M., additional, Lievens, Yolande, additional, Dieleman, Edith, additional, Jaspers, Jaap, additional, van Meerbeeck, Jan, additional, Ubbels, J., additional, Kwint, Margriet, additional, Kuenen, Marianne, additional, Deprez, Sabine, additional, de Ruiter, Michiel, additional, Boogerd, Willem, additional, Sikorska, Karolina, additional, van Tinteren, Harm, additional, and Schagen, Sanne, additional

Published
2020
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13. Patient-reported burden of intensified surveillance and surgery in high-risk individuals under pancreatic cancer surveillance

Author

Overbeek, Kasper, primary, Cahen, Djuna, additional, Kamps, Anne, additional, Konings, Ingrid, additional, Harinck, Femme, additional, Kuenen, Marianne, additional, Koerkamp, Bas Groot, additional, Besselink, Marc G., additional, van Eijck, Casper, additional, Wagner, Anja, additional, Ausems, Margreet, additional, van der Vlugt, Manon, additional, Fockens, Paul, additional, Vleggaar, Frank, additional, Poley, Jan-Werner, additional, van Hooft, Jeanin E., additional, Bleiker, Eveline, additional, and Bruno, Marco J., additional

Published
2019
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14. Sa1365 – Patient-Reported Burden of Intensified Surveillance and Surgery in High-Risk Individuals Under Pancreatic Cancer Surveillance

Author

Overbeek, Kasper A., primary, Cahen, Djuna, additional, Kamps, Anne, additional, Konings, Ingrid C., additional, Harinck, Femme, additional, Kuenen, Marianne A., additional, Koerkamp, B. Groot, additional, Besselink, Marc, additional, Wagner, Anja, additional, Ausems, Margreet G., additional, van der Vlugt, Manon, additional, Fockens, Paul, additional, Vleggaar, Frank P., additional, Poley, Jan-Werner, additional, van Hooft, Jeanin E., additional, Bleiker, Eveline M., additional, and Bruno, Marco J., additional

Published
2019
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15. Efficacy of Internet-Based Cognitive Behavioral Therapy for Treatment-Induced Menopausal Symptoms in Breast Cancer Survivors: Results of a Randomized Controlled Trial

Author

Atema, Vera, primary, van Leeuwen, Marieke, additional, Kieffer, Jacobien M., additional, Oldenburg, Hester S.A., additional, van Beurden, Marc, additional, Gerritsma, Miranda A., additional, Kuenen, Marianne A., additional, Plaisier, Peter W., additional, Lopes Cardozo, Alexander M.F., additional, van Riet, Yvonne E.A., additional, Heuff, Gijsbert, additional, Rijna, Herman, additional, van der Meij, Suzan, additional, Noorda, Eva M., additional, Timmers, Gert-Jan, additional, Vrouenraets, Bart C., additional, Bollen, Matthé, additional, van der Veen, Henk, additional, Bijker, Nina, additional, Hunter, Myra S., additional, and Aaronson, Neil K., additional

Published
2019
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16. Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance

Author

Konings, Ingrid C A W, Harinck, Femme, Kuenen, Marianne A, Sidharta, Grace N, Kieffer, Jacobien M, Aalfs, Cora M, Poley, Jan-Werner, Smets, Ellen M A, Wagner, Anja, van Rens, Anja, Vleggaar, Frank P, Ausems, Margreet G E M, Fockens, Paul, van Hooft, Jeanin E, Bruno, Marco J, Bleiker, Eveline M A, and Dutch research group on pancreatic cancer surveillance in high-risk individuals

Subjects
Surveillance, Cancer worries, High-risk individuals, Journal Article, Pancreatic cancer, Psychosocial burden, Predictive factors
Abstract

It is important to adequately and timely identify individuals with cancer worries amongst participants in a pancreatic ductal adenocarcinoma (PDAC) surveillance program, because they could benefit from psychosocial support to decrease distress. Therefore, the aim of this study was to assess both psychosocial and clinical factors associated with cancer worries. High-risk individuals participating in PDAC-surveillance were invited to annually complete a cancer worry scale (CWS) questionnaire which was sent after counseling by the clinical geneticist (T0), after intake for participation in PDAC-surveillance (T1), and then annually after every MRI and endoscopic ultrasonography (EUS) (T2 and further). Analyses were performed to identify factors associated with cancer worries in the second year of surveillance (T3). We found a significant intra-individual decrease in cancer worries (β = -0.84, P < 0.001), nevertheless, 33 % of individuals had a CWS-score ≥14 at T3. We found one factor significantly associated with cancer worries at T3: having a family member affected by PDAC

Published
2017

17. Patient-reported burden of intensified surveillance and surgery in high-risk individuals under pancreatic cancer surveillance.

Author

Overbeek, Kasper A., Cahen, Djuna L., Kamps, Anne, Konings, Ingrid C. A. W., Harinck, Femme, Kuenen, Marianne A., Koerkamp, Bas Groot, Besselink, Marc G., van Eijck, Casper H., Wagner, Anja, Ausems, Margreet G. E., van der Vlugt, Manon, Fockens, Paul, Vleggaar, Frank P., Poley, Jan-Werner, van Hooft, Jeanin E., Bleiker, Eveline M. A., Bruno, Marco J., the Dutch Familial Pancreatic Cancer Surveillance Study Group, and Bruno, M. J.

Subjects
PANCREATIC cancer, PATIENTS' attitudes, EXOCRINE pancreatic insufficiency, PANCREATIC surgery, SURGERY
Abstract

In high-risk individuals participating in a pancreatic cancer surveillance program, worrisome features warrant for intensified surveillance or, occasionally, surgery. Our objectives were to determine the patient-reported burden of intensified surveillance and/or surgery, and to assess post-operative quality of life and opinion of surgery. Participants in our pancreatic cancer surveillance program completed questionnaires including the Cancer Worry Scale (CWS) and the Hospital Anxiety and Depression Scale (HADS). For individuals who underwent intensified surveillance, questionnaires before, during, and ≥ 3 weeks after were analyzed. In addition, subjects who underwent intensified surveillance in the past 3 years or underwent surgery at any time, were invited for an interview, that included the Short-Form 12 (SF-12). A total of 31 high-risk individuals were studied. During the intensified surveillance period, median CWS scores were higher (14, IQR 7), as compared to before (12, IQR 9, P = 0.007) and after (11, IQR 7, P = 0.014), but eventually returned back to baseline (P = 0.823). Median HADS scores were low: 5 (IQR 6) for anxiety and 3 (IQR 5) for depression, and they were unaffected by the intensified surveillance period. Of the 10 operated patients, 1 (10%) developed diabetes and 7 (70%) pancreatic exocrine insufficiency. The interviews yielded median quality-of-life scores comparable to the general population. Also, after surgery, patients' attitudes towards surveillance were unchanged (5/10, 50%) or became more positive (4/10, 40%). Although patients were aware of the (sometimes benign) pathological outcome, when asked if surgery had been justified, only 20% (2/10) disagreed, and all would again have chosen to undergo surgery. In conclusion, in individuals at high risk for pancreatic cancer, intensified surveillance temporarily increased cancer worries, without affecting general anxiety or depression. Although pancreatic surgery led to substantial co-morbidity, quality of life was similar to the general population, and surgery did not negatively affect the attitude towards surveillance. [ABSTRACT FROM AUTHOR]

Published
2020
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18. Sexual Functioning and Relationship Satisfaction of Partners of Breast Cancer Survivors Who Receive Internet-Based Sex Therapy

Author

Hummel, Susanna B., primary, van Lankveld, Jacques J.D.M., additional, Oldenburg, Hester S.A., additional, Hahn, Daniela E.E., additional, Kieffer, Jacobien M., additional, Gerritsma, Miranda A., additional, Kuenen, Marianne A., additional, Bijker, Nina, additional, Borgstein, Paul J., additional, Heuff, Gijsbert, additional, Lopes Cardozo, Alexander M.F., additional, Plaisier, Peter W., additional, Rijna, Herman, additional, van der Meij, Suzan, additional, van Dulken, Eric J., additional, Vrouenraets, Bart C., additional, Broomans, Eva, additional, and Aaronson, Neil K., additional

Published
2018
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19. Internet-Based Cognitive Behavioral Therapy Realizes Long-Term Improvement in the Sexual Functioning and Body Image of Breast Cancer Survivors

Author

Hummel, Susanna B., primary, van Lankveld, Jacques J. D. M., additional, Oldenburg, Hester S. A., additional, Hahn, Daniela E. E., additional, Kieffer, Jacobien M., additional, Gerritsma, Miranda A., additional, Kuenen, Marianne A., additional, Bijker, Nina, additional, Borgstein, Paul J., additional, Heuff, Gijsbert, additional, Cardozo, Alexander M. F. Lopes, additional, Plaisier, Peter W., additional, Rijna, Herman, additional, van der Meij, Suzan, additional, van Dulken, Eric J., additional, Vrouenraets, Bart C., additional, Broomans, Eva, additional, and Aaronson, Neil K., additional

Published
2018
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20. Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance

Author

MS MDL Oncologie, Cancer, MS MDL 1, Genetica Sectie Oncogenetica, Child Health, Konings, Ingrid C A W, Harinck, Femme, Kuenen, Marianne A, Sidharta, Grace N, Kieffer, Jacobien M, Aalfs, Cora M, Poley, Jan-Werner, Smets, Ellen M A, Wagner, Anja, van Rens, Anja, Vleggaar, Frank P, Ausems, Margreet G E M, Fockens, Paul, van Hooft, Jeanin E, Bruno, Marco J, Bleiker, Eveline M A, Dutch Research Group on Pancreatic Cancer Surveillance in High-Risk Individuals, MS MDL Oncologie, Cancer, MS MDL 1, Genetica Sectie Oncogenetica, Child Health, Konings, Ingrid C A W, Harinck, Femme, Kuenen, Marianne A, Sidharta, Grace N, Kieffer, Jacobien M, Aalfs, Cora M, Poley, Jan-Werner, Smets, Ellen M A, Wagner, Anja, van Rens, Anja, Vleggaar, Frank P, Ausems, Margreet G E M, Fockens, Paul, van Hooft, Jeanin E, Bruno, Marco J, Bleiker, Eveline M A, and Dutch Research Group on Pancreatic Cancer Surveillance in High-Risk Individuals

Published
2017

21. Repeated participation in pancreatic cancer surveillance by high-risk individuals imposes low psychological burden

Author

Konings, Ingrid C. A. W., Sidharta, Grace N., Harinck, Femme, Aalfs, Cora M., Poley, Jan-Werner, Kieffer, Jacobien M., Kuenen, Marianne A., Smets, Ellen M. A., Wagner, Anja, van Hooft, Jeanin E., van Rens, Anja, Fockens, Paul, Bruno, Marco J., Bleiker, Eveline M. A., Gastroenterology & Hepatology, Clinical Genetics, Other departments, Human Genetics, Medical Psychology, and Gastroenterology and Hepatology

Subjects
SDG 3 - Good Health and Well-being
Abstract

Background: When assessing the feasibility of surveillance for pancreatic cancer (PC), it is important to address its psychological burden. The aim of this ongoing study is to evaluate the psychological burden of annual pancreatic surveillance for individuals at high risk to develop PC. Methods: This is a multicenter prospective study. High-risk individuals who undergo annual pancreatic surveillance with magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) were invited to complete questionnaires to assess motivations for participating in surveillance, experiences with participation, perceived PC risk, topics of concern, and psychological distress. Questionnaires were sent after intake for participation (Ti), after the first MRI and EUS (T2), and after the MRI and EUS 1 (T3), 2 (T4), and 3 years (T5) after first surveillance. Results: In total, 140 out of 152 individuals returned one or more of the questionnaires (response 92%); 477 questionnaires were analyzed. The most frequently reported motivation for participating in surveillance was the possible early detection of (a precursor stage oi) cancer (95-100%). Only a minority of respondents experienced MRI and EUS as uncomfortable (10% and 11%, respectively), and respondents dreaded their next EUS investigation less as surveillance progressed. Respondents' cancer worries decreased significantly over time, and both their anxiety and depression scores remained stable and low over the 3-year period of follow-up. Conclusions: The psychological burden of pancreatic surveillance is low at all assessments. Therefore, from a psychological point of view, participation of high-risk individuals in an annual pancreatic surveillance program is feasible. Copyright (C) 2015 John Wiley & Sons, Ltd.

Published
2016

22. Efficacy of Internet-Based Cognitive Behavioral Therapy in Improving Sexual Functioning of Breast Cancer Survivors: Results of a Randomized Controlled Trial

Author

Hummel, Susanna B., primary, van Lankveld, Jacques J.D.M., additional, Oldenburg, Hester S.A., additional, Hahn, Daniela E.E., additional, Kieffer, Jacobien M., additional, Gerritsma, Miranda A., additional, Kuenen, Marianne A., additional, Bijker, Nina, additional, Borgstein, Paul J., additional, Heuff, Gijsbert, additional, Lopes Cardozo, Alexander M.F., additional, Plaisier, Peter W., additional, Rijna, Herman, additional, van der Meij, Suzan, additional, van Dulken, Eric J., additional, Vrouenraets, Bart C., additional, Broomans, Eva, additional, and Aaronson, Neil K., additional

Published
2017
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23. Sexual Functioning and Relationship Satisfaction of Partners of Breast Cancer Survivors Who Receive Internet-Based Sex Therapy.

Author

Hummel, Susanna B., van Lankveld, Jacques J.D.M., Oldenburg, Hester S.A., Hahn, Daniela E.E., Kieffer, Jacobien M., Gerritsma, Miranda A., Kuenen, Marianne A., Bijker, Nina, Borgstein, Paul J., Heuff, Gijsbert, Lopes Cardozo, Alexander M.F., Plaisier, Peter W., Rijna, Herman, van der Meij, Suzan, van Dulken, Eric J., Vrouenraets, Bart C., Broomans, Eva, and Aaronson, Neil K.

Subjects
SEX therapy, SEXUAL excitement, BREAST cancer, CANCER patients, BEHAVIOR therapy
Abstract

As part of a larger, randomized controlled trial, we evaluated longitudinally the sexual functioning and relationship satisfaction of 69 partners of breast cancer (BC) survivors who received Internet-based cognitive behavioral therapy (CBT) for sexual dysfunction. The findings suggest that Internet-based CBT positively affects the partners' immediate post-CBT and longer-term overall sexual satisfaction, sexual intimacy, and sexual relationship satisfaction. No sustained changes in other areas of sexual functioning were observed. Our CBT program was focused primarily on the sexual health of the BC survivors. We recommend that future programs include more psychoeducational and behavioral elements targeted at the partners. [ABSTRACT FROM AUTHOR]

Published
2019
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24. Sa1773 Factors Associated With Cancer Worries in Individuals Participating in Annual Pancreatic Cancer Surveillance

Author

Konings, Ingrid C., primary, Harinck, Femme, additional, Kuenen, Marianne A., additional, Kieffer, Jacobien M., additional, Aalfs, Cora M., additional, Poley, Jan-Werner, additional, Smets, Ellen M., additional, Wagner, Anja, additional, van Rens, Anja, additional, Vleggaar, Frank P., additional, Ausems, Margreet G., additional, Fockens, Paul, additional, van Hooft, Jeanin E., additional, Bruno, Marco J., additional, and Bleiker, Eveline M., additional

Published
2016
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25. Repeated participation in pancreatic cancer surveillance by high-risk individuals imposes low psychological burden

Author

Konings, Ingrid C. A. W., primary, Sidharta, Grace N., additional, Harinck, Femme, additional, Aalfs, Cora M., additional, Poley, Jan-Werner, additional, Kieffer, Jacobien M., additional, Kuenen, Marianne A., additional, Smets, Ellen M. A., additional, Wagner, Anja, additional, van Hooft, Jeanin E., additional, van Rens, Anja, additional, Fockens, Paul, additional, Bruno, Marco J., additional, and Bleiker, Eveline M. A., additional

Published
2015
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27. Late cardiotoxicity after treatment for Hodgkin lymphoma

Author

Aleman, Berthe M. P., primary, van den Belt-Dusebout, Alexandra W., additional, De Bruin, Marie L., additional, van 't Veer, Mars B., additional, Baaijens, Margreet H. A., additional, Boer, Jan Paul de, additional, Hart, Augustinus A. M., additional, Klokman, Willem J., additional, Kuenen, Marianne A., additional, Ouwens, Gabey M., additional, Bartelink, Harry, additional, and van Leeuwen, Flora E., additional

Published
2006
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29. Late cardiotoxicity after treatment for Hodgkin lymphoma

Author

Aleman, Berthe M. P., van den Belt-Dusebout, Alexandra W., De Bruin, Marie L., van 't Veer, Mars B., Baaijens, Margreet H. A., Boer, Jan Paul de, Hart, Augustinus A. M., Klokman, Willem J., Kuenen, Marianne A., Ouwens, Gabey M., Bartelink, Harry, and van Leeuwen, Flora E.

Abstract

We assessed cardiovascular disease (CVD) incidence in 1474 survivors of Hodgkin lymphoma (HL) younger than 41 years at treatment (1965-1995). Multivariable Cox regression and competing risk analyses were used to quantify treatment effects on CVD risk. After a median follow-up of 18.7 years, risks of myocardial infarction (MI) and congestive heart failure (CHF) were strongly increased compared with the general population (standardized incidence ratios [SIRs] = 3.6 and 4.9, respectively), resulting in 35.7 excess cases of MI and 25.6 excess cases of CHF per 10 000 patients/year. SIRs of all CVDs combined remained increased for at least 25 years and were more strongly elevated in younger patients. Mediastinal radiotherapy significantly increased the risks of MI, angina pectoris, CHF, and valvular disorders (2- to 7-fold). Anthracyclines significantly added to the elevated risks of CHF and valvular disorders from mediastinal RT (hazard ratios [HRs] were 2.81 and 2.10, respectively). The 25-year cumulative incidence of CHF after mediastinal radiotherapy and anthracyclines in competing risk analyses was 7.9%. In conclusion, risks of several CVDs are 3- to 5-fold increased in survivors of HL compared with the general population, even after prolonged follow-up, leading to increasing absolute excess risks over time. Anthracyclines further increase the elevated risks of CHF and valvular disorders from mediastinal radiotherapy.

Published
2007
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30. Phase III randomized trial of Prophylactic Cranial Irradiation with or without Hippocampus Avoidance in SCLC (NCT01780675)

Author

Belderbos, Jose, De Ruysscher, Dirk, De Jaeger, Katrien, Koppe, Friederike, Lambrecht, Maarten, Lievens, Yolande, Dieleman, Edith, Jaspers, Jaap, Van Meerbeeck, Jan, Ubbels, Fred, Kwint, Magriet, Kuenen, Marianne, Deprez, Sabine, De Ruiter, Michiel, Boogerd, Willem, Sikorska, Karolina, Van Tinteren, Harm, and Schagen, Sanne B.

Abstract

To compare neurocognitive functioning in Small Cell Lung Cancer patients(SCLC) who received prophylactic cranial irradiation(PCI) with or without hippocampus avoidance (HA).

Published
2021
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31. Efficacy of a Decision Aid in Breast Cancer Patients Considering Immediate Reconstruction: Results of a Randomized Controlled Trial.

Author

Ter Stege JA, Woerdeman LAE, Kieffer JM, Sherman KA, Agelink van Rentergem JA, van Duijnhoven FH, van Huizum MA, Gerritsma MA, Kuenen M, Corten EML, Kimmings NAN, Ruhé QPQ, Krabbe-Timmerman IS, Van't Riet M, Hahn DEE, Witkamp AJ, Oldenburg HSA, and Bleiker EMA

Subjects
Humans, Female, Middle Aged, Adult, Decision Making, Aged, Breast Neoplasms surgery, Breast Neoplasms psychology, Mammaplasty methods, Mammaplasty psychology, Mastectomy, Decision Support Techniques, Patient Satisfaction
Abstract

Background: Breast cancer patients face complex decisions about immediate breast reconstruction (BR) after mastectomy. The authors evaluated the efficacy of an online decision aid in improving the decision-making process, decision quality, and health outcomes in breast cancer patients considering immediate BR., Methods: In a multicenter, randomized, controlled trial, patients were allocated to either the intervention group, receiving care as usual with access to an online decision aid, or the control group, receiving care as usual with an information leaflet. The primary outcome was decisional conflict. Secondary outcomes assessed the process of decision-making (eg, preparation for decision-making, satisfaction with information), decision quality (decision regret, knowledge), and health outcomes (eg, satisfaction with BR outcomes, body image). Patients completed questionnaires at time (T) 0 (baseline); T1 (1 week after consultation with a plastic surgeon); and T2 (3 months) and T3 (12 months) after surgery., Results: The authors included 250 patients. Decisional conflict decreased over time in both groups, with no between-group differences. Intervention participants felt better prepared for decision-making than controls ( P = 0.002). At T2, 87% of intervention participants were very satisfied with the information about BR, compared with 73% of control participants ( P = 0.011). No significant between-group differences were observed in any other outcome., Conclusions: The authors' online decision aid was as effective in reducing decisional conflict as an information leaflet about immediate BR after mastectomy. However, the decision aid substantially improved the decision-making process by better preparing breast cancer patients for decisions about immediate BR., Clinical Question/level of Evidence: Therapeutic, II., (Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Plastic Surgeons.)

Published
2024
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32. Repeated participation in pancreatic cancer surveillance by high-risk individuals imposes low psychological burden.

Author

Konings IC, Sidharta GN, Harinck F, Aalfs CM, Poley JW, Kieffer JM, Kuenen MA, Smets EM, Wagner A, van Hooft JE, van Rens A, Fockens P, Bruno MJ, and Bleiker EM

Subjects
Aged, Anxiety psychology, Depression psychology, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Risk Factors, Surveys and Questionnaires, Cost of Illness, Early Detection of Cancer psychology, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms psychology
Abstract

Background: When assessing the feasibility of surveillance for pancreatic cancer (PC), it is important to address its psychological burden. The aim of this ongoing study is to evaluate the psychological burden of annual pancreatic surveillance for individuals at high risk to develop PC., Methods: This is a multicenter prospective study. High-risk individuals who undergo annual pancreatic surveillance with magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) were invited to complete questionnaires to assess motivations for participating in surveillance, experiences with participation, perceived PC risk, topics of concern, and psychological distress. Questionnaires were sent after intake for participation (T1), after the first MRI and EUS (T2), and after the MRI and EUS 1 (T3), 2 (T4), and 3 years (T5) after first surveillance., Results: In total, 140 out of 152 individuals returned one or more of the questionnaires (response 92%); 477 questionnaires were analyzed. The most frequently reported motivation for participating in surveillance was the possible early detection of (a precursor stage of) cancer (95-100%). Only a minority of respondents experienced MRI and EUS as uncomfortable (10% and 11%, respectively), and respondents dreaded their next EUS investigation less as surveillance progressed. Respondents' cancer worries decreased significantly over time, and both their anxiety and depression scores remained stable and low over the 3-year period of follow-up., Conclusions: The psychological burden of pancreatic surveillance is low at all assessments. Therefore, from a psychological point of view, participation of high-risk individuals in an annual pancreatic surveillance program is feasible.Copyright © 2015 John Wiley & Sons, Ltd., (Copyright © 2015 John Wiley & Sons, Ltd.)

Published
2016
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