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2. Liver stiffness assessed by magnetic resonance elastography predicts clinical outcomes in patients with heart failure and without chronic liver disease

Author

Tada, Atsushi, Nagai, Toshiyuki, Kato, Yoshiya, Omote, Kazunori, Oyama-Manabe, Noriko, Tsuneta, Satonori, Kudo, Yusuke, Nishida, Mutsumi, Nakai, Michikazu, Takahashi, Yuki, Saiin, Kohei, Naito, Seiichiro, Kobayashi, Yuta, Takenaka, Sakae, Mizuguchi, Yoshifumi, Kamiya, Kiwamu, Konishi, Takao, Sato, Takuma, Kudo, Kohsuke, and Anzai, Toshihisa

Published
2023
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7. Baseline elevated serum angiopoietin-2 predicts long-term non-regression of liver fibrosis after direct-acting antiviral therapy for hepatitis C

Author

Kawagishi, Naoki, Suda, Goki, Kimura, Megumi, Maehara, Osamu, Yamada, Ren, Tokuchi, Yoshimasa, Kubo, Akinori, Kitagataya, Takashi, Shigesawa, Taku, Suzuki, Kazuharu, Ohara, Masatsugu, Nakai, Masato, Sho, Takuya, Natsuizaka, Mitsuteru, Morikawa, Kenichi, Ogawa, Koji, Kudo, Yusuke, Nishida, Mutsumi, and Sakamoto, Naoya

Published
2021
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20. Liver stiffness assessed by magnetic resonance elastography predicts clinical outcomes in patients with heart failure and without chronic liver disease

Author

Tada, Atsushi, primary, Nagai, Toshiyuki, additional, Kato, Yoshiya, additional, Omote, Kazunori, additional, Oyama-Manabe, Noriko, additional, Tsuneta, Satonori, additional, Kudo, Yusuke, additional, Nishida, Mutsumi, additional, Nakai, Michikazu, additional, Takahashi, Yuki, additional, Saiin, Kohei, additional, Naito, Seiichiro, additional, Kobayashi, Yuta, additional, Takenaka, Sakae, additional, Mizuguchi, Yoshifumi, additional, Kamiya, Kiwamu, additional, Konishi, Takao, additional, Sato, Takuma, additional, Kudo, Kohsuke, additional, and Anzai, Toshihisa, additional

Published
2022
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21. High serum angiopoietin-2 level predicts non-regression of liver stiffness measurement-based liver fibrosis stage after direct-acting antiviral therapy for hepatitis C

Author

Kawagishi, Naoki, Suda, Goki, Kimura, Megumi, Maehara, Osamu, Shimazaki, Tomoe, Yamada, Ren, Kitagataya, Takashi, Shigesawa, Taku, Suzuki, Kazuharu, Nakamura, Akihisa, Ohara, Masatsugu, Umemura, Machiko, Nakai, Masato, Sho, Takuya, Natsuizaka, Mitsuteru, Morikawa, Kenichi, Ogawa, Koji, Kudo, Yusuke, Nishida, Mutsumi, and Sakamoto, Naoya

Subjects
HCV, angiopoietin-2, liver stiffness measurement, DAA
Abstract

Aim Factors associated with improvement of liver fibrosis after successful hepatitis C virus (HCV) eradication by interferon (IFN)-free direct-acting antiviral agents (DAAs) have been not clarified well. Angiopoietin-2 (Ang2) is reported to be associated with vascular leak and inflammation observed in patients with advanced liver fibrosis. Methods In this retrospective study, patients treated with IFN-free DAAs who underwent transient elastography before and at 24-weeks post-treatment and achieved sustained viral response were enrolled. Baseline serum Ang2 was measured, and its relationship with other clinical factors was analyzed. Liver fibrosis stage was defined based on liver stiffness according to a previous report. Predictive factors for regression of liver fibrosis stage after DAA therapy were evaluated. Results Overall, 116 patients were analyzed. Baseline serum Ang2 levels were significantly associated with liver stiffness, spleen index, and liver stiffness-based liver fibrosis stage. Moreover, 75% of patients experienced regression of liver fibrosis stage after DAA therapy. Multivariate analysis revealed that advanced liver fibrosis stage and Ang2 levels were significantly associated with regression of liver fibrosis stage after DAA therapy. In patients with advanced liver fibrosis (F3/4), baseline Ang2 level alone could predict regression of liver fibrosis stage. A baseline Ang2 cut-off value (354?pg/ML) could predict regression of liver fibrosis stage after DAA therapy with high accuracy (sensitivity 0.882, specificity 0.733). Conclusions Evaluation of serum Ang2 levels before DAA therapy is important. Our results provide a novel mechanistic insight into non-regression of liver stiffness after DAA therapy. Long-term and larger studies are required.

Published
2020

23. Transabdominal Ultrasonography for Preoperative Diagnosis of Lymph Node Metastasis in Colon Cancer: A Retrospective Cohort Study

Author

IMAIZUMI, KEN, primary, HOMMA, SHIGENORI, additional, NISHIDA, MUTSUMI, additional, SOYAMA, TAKESHI, additional, SHIMURA, RYOSUKE, additional, KUDO, YUSUKE, additional, OMOTEHARA, SATOMI, additional, YOKOTA, ISAO, additional, TAKAGI, RYO, additional, MATSUI, HIROKI, additional, MIYAOKA, YOICHI, additional, ICHIKAWA, NOBUKI, additional, YOSHIDA, TADASHI, additional, TAKAHASHI, NORIHIKO, additional, and TAKETOMI, AKINOBU, additional

Published
2022
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25. Transabdominal ultrasonography for the preoperative diagnosis of advanced lymph node metastasis in patients with colon cancer: A retrospective cohort study

Author

Imaizumi, Ken, primary, Homma, Shigenori, additional, Nishida, Mutsumi, additional, Soyama, Takeshi, additional, Shimura, Ryosuke, additional, Kudo, Yusuke, additional, Omotehara, Satomi, additional, Yokota, Isao, additional, Takagi, Ryo, additional, Matsui, Hiroki, additional, Miyaoka, Yoichi, additional, Ichikawa, Nobuki, additional, Yoshida, Tadashi, additional, Takahashi, Norihiko, additional, and Taketomi, Akinobu, additional

Published
2021
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27. The impact of elastography with virtual touch quantification of future remnant liver before major hepatectomy

Author

Shimada, Shingo, Kamiyama, Toshiya, Kakisaka, Tatsuhiko, Orimo, Tatsuya, Nagatsu, Akihisa, Asahi, Yoh, Sakamoto, Yuzuru, Kamachi, Hirofumi, Kudo, Yusuke, Nishida, Mutsumi, 1000070363364, Taketomi, Akinobu, Shimada, Shingo, Kamiyama, Toshiya, Kakisaka, Tatsuhiko, Orimo, Tatsuya, Nagatsu, Akihisa, Asahi, Yoh, Sakamoto, Yuzuru, Kamachi, Hirofumi, Kudo, Yusuke, Nishida, Mutsumi, 1000070363364, and Taketomi, Akinobu

Abstract

Background: Liver elastography with virtual touch quantification (VTQ) measures the velocity of the shear wave generated by a short-duration acoustic force impulse, with values expressed in units of velocity (m/s). VTQ can evaluate right or left hepatic lobes separately. VTQ might be appropriate for the evaluation of future remnant liver after hepatectomy. Methods: We analyzed 95 patients underwent liver elastography with VTQ and both future remnant liver and resected side before hepatectomy of more than two sections, except for central bisectionectomy. We divided the patients into a high VTQ group (>= 1.52 m/s, n=37, 39%) and a low VTQ group (<1.52 m/s, n=58, 61%) according to the VTQ of future remnant liver. Transient elastography could not be performed in 22 cases due to tumor size. We defined the group with liver stiffness measurement (LSM) >= 7.9 kPa as the high LSM group (n=29, 40%) and those with LSM <7.9 kPa as the low LSM group (n=44, 60%). We investigated the outcome after hepatectomy and the correlations between the VTQ of future remnant liver and other indicators for hepatic fibrosis. Results: The high VTQ group showed significantly higher postoperative ascites (19% vs. 3%; P=0.01), pathological fibrosis (19% vs. 5%; P=0.03), and rates of patients with postoperative T-bil >= 2.0 mg/dL (70% vs. 40%; P<0.01). The high LSM group showed no significant postoperative outcomes compared to the low LSM group. The high VTQ group showed a higher frequency of male gender (78% vs. 57%; P=0.03), higher indocyanine green retention rate at 15 min (ICGR15) (10.5% vs. 6.3%; P<0.01), hyaluronic acid (100 vs. 67 ng/mL; P=0.02), type IV collagen 7S (7.6 vs. 5.1 ng/mL; P<0.01), Mac-2 binding protein glycan isomer (M2BPGi) (1.19 vs. 1.00; P=0.01), Fibrosis-4 (FIB-4) index (2.25 vs. 1.76; P=0.01), and aspartate aminotransferase to platelet ratio index (APRI) score (0.64 vs. 0.41; P<0.01). We also observed an especially strong positive correlation betw

Published
2021

30. Baseline Elevated Serum Angiopoietin-2 Predicts Long-Term Non-Regression of Liver Fibrosis After Direct-Acting Antiviral Therapy for Hepatitis C

Author

Suda, Goki, primary, Kawagishi, Naoki, additional, Kimura, Megumi, additional, Maehara, Osamu, additional, Yamada, Ren, additional, Tokuchi, Yoshimasa, additional, Kubo, Akinori, additional, Kitagataya, Takashi, additional, Shigesawa, Taku, additional, Suzuki, Kazuharu, additional, Ohara, Masatsugu, additional, Nakai, Masato, additional, Sho, Takuya, additional, Natsuizaka, Mitsuteru, additional, Morikawa, Kenichi, additional, Ogawa, Koji, additional, Kudo, Yusuke, additional, Nishida, Mutsumi, additional, and Sakamoto, Naoya, additional

Published
2021
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36. Case with long-standing gout showing various ultrasonographic features caused by monosodium urate monohydrate crystal deposition

Author

Murayama, Michito, primary, Nishida, Mutsumi, additional, Kudo, Yusuke, additional, Deguchi, Takahiro, additional, Marukawa, Katsuji, additional, Fujieda, Yuichiro, additional, Abe, Nobuya, additional, Kato, Masaru, additional, Shibuya, Hitoshi, additional, Matsuno, Yoshihiro, additional, and Atsumi, Tatsuya, additional

Published
2019
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37. Assessing the risk of hepatocellular carcinoma by combining liver stiffness and the controlled attenuation parameter

Author

Izumi, Takaaki, primary, Sho, Takuya, additional, Morikawa, Kenichi, additional, Shigesawa, Taku, additional, Suzuki, Kazuharu, additional, Nakamura, Akihisa, additional, Ohara, Masatsugu, additional, Kawagishi, Naoki, additional, Umemura, Machiko, additional, Shimazaki, Tomoe, additional, Kimura, Megumi, additional, Nakai, Masato, additional, Suda, Goki, additional, Natsuizaka, Mitsuteru, additional, Ogawa, Koji, additional, Kudo, Yusuke, additional, Nishida, Mutsumi, additional, Ono, Kota, additional, Baba, Masaru, additional, Furuya, Ken, additional, and Sakamoto, Naoya, additional

Published
2019
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39. Liver steatosis and dyslipidemia after HCV eradication by direct acting antiviral agents are synergistic risks of atherosclerosis

Author

Kawagishi, Naoki, primary, Suda, Goki, additional, Nakamura, Akinobu, additional, Kimura, Megumi, additional, Maehara, Osamu, additional, Suzuki, Kazuharu, additional, Nakamura, Akihisa, additional, Ohara, Masatsugu, additional, Izumi, Takaaki, additional, Umemura, Machiko, additional, Nakai, Masato, additional, Sho, Takuya, additional, Natsuizaka, Mitsuteru, additional, Morikawa, Kenichi, additional, Ogawa, Koji, additional, Kudo, Yusuke, additional, Nishida, Mutsumi, additional, Miyoshi, Hideaki, additional, and Sakamoto, Naoya, additional

Published
2018
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40. Impact of admission liver stiffness on long-term clinical outcomes in patients with acute decompensated heart failure

Author

Omote, Kazunori, primary, Nagai, Toshiyuki, additional, Asakawa, Naoya, additional, Kamiya, Kiwamu, additional, Tokuda, Yusuke, additional, Aikawa, Tadao, additional, Fukushima, Arata, additional, Noguchi, Keiji, additional, Kato, Yoshiya, additional, Komoriyama, Hirokazu, additional, Nishida, Mutsumi, additional, Kudo, Yusuke, additional, Iwano, Hiroyuki, additional, Yokota, Takashi, additional, and Anzai, Toshihisa, additional

Published
2018
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42. Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

Author

1000090404722, Nishida, Mutsumi, Kahata, Kaoru, Hayase, Eiko, Shigematsu, Akio, Sato, Megumi, Kudo, Yusuke, Omotehara, Satomi, Iwai, Takahito, Sugita, Junichi, Shibuya, Hitoshi, 1000000292029, Shimizu, Chikara, 1000040284096, Teshima, Takanori, 1000090404722, Nishida, Mutsumi, Kahata, Kaoru, Hayase, Eiko, Shigematsu, Akio, Sato, Megumi, Kudo, Yusuke, Omotehara, Satomi, Iwai, Takahito, Sugita, Junichi, Shibuya, Hitoshi, 1000000292029, Shimizu, Chikara, 1000040284096, and Teshima, Takanori

Abstract

Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables the visualization of blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel US diagnostic scoring system of SOS/VOD based on US findings. We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT. Among 106 patients, 10 patients (9.4%) were diagnosed as SOS/VOD by Baltimore or Seattle criteria. According to uni-variate analysis of 17 US findings (US-17 screening), we established a novel scoring system (HokUS-10) consisting of 10 parameters, such as gallbladder wall thickening, ascites, and blood flow signal in the paraumbilical vein. The sensitivity and specificity were 100% and 95.8%, respectively. Diagnostic performance of the HokUS-10 was significantly better than US-17 screening. In 4 of 10 patients US detection of SOS/VOD preceded to clinical diagnosis. The HokUS-10 scoring system is useful in the diagnosis of SOS/VOD; however, our results should be validated in other cohorts.

Published
2018

43. Liver steatosis and dyslipidemia after HCV eradication by direct acting antiviral agents are synergistic risks of atherosclerosis

Author

Kawagishi, Naoki, 1000020447460, Suda, Goki, 1000070552420, Nakamura, Akinobu, Kimura, Megumi, Maehara, Osamu, Suzuki, Kazuharu, Nakamura, Akihisa, Ohara, Masatsugu, Izumi, Takaaki, Umemura, Machiko, Nakai, Masato, Sho, Takuya, 1000080642446, Natsuizaka, Mitsuteru, Morikawa, Kenichi, 1000020735188, Ogawa, Koji, Kudo, Yusuke, 1000090404722, Nishida, Mutsumi, 1000030360902, Miyoshi, Hideaki, 1000010334418, Sakamoto, Naoya, Kawagishi, Naoki, 1000020447460, Suda, Goki, 1000070552420, Nakamura, Akinobu, Kimura, Megumi, Maehara, Osamu, Suzuki, Kazuharu, Nakamura, Akihisa, Ohara, Masatsugu, Izumi, Takaaki, Umemura, Machiko, Nakai, Masato, Sho, Takuya, 1000080642446, Natsuizaka, Mitsuteru, Morikawa, Kenichi, 1000020735188, Ogawa, Koji, Kudo, Yusuke, 1000090404722, Nishida, Mutsumi, 1000030360902, Miyoshi, Hideaki, 1000010334418, and Sakamoto, Naoya

Abstract

Aim: We comprehensively analyzed how hepatitis C virus (HCV) eradication by interferon (IFN)-free direct-acting-antiviral-agents (DAAs) affects liver steatosis and atherogenic risk. Methods: Patients treated with IFN-free-DAAs who underwent transient elastography before and at 24-weeks post-treatment, including controlled attenuation parameter (CAP), and achieved sustained viral response (SVR) were enrolled. The association between changes in liver steatosis, lipid-metabolism, and genetic and clinical factors was analyzed. Results: A total of 117 patients were included. The mean CAP and low-density lipoprotein cholesterol (LDL-C) levels were significantly elevated at SVR24. However, baseline LDL-C and CAP values were significantly negatively correlated with changes in these values after HCV eradication, indicating that in patients with high baseline values, the values generally decreased after HCV eradication. Mean small-dense LDL-C (sdLDL-C), which has greater atherogenic potential, was significantly elevated only in patients with both dyslipidemia (LDL-C >140 mg/dL) and liver steatosis (CAP >248 dB/m) at SVR24. Those patients had significant higher baseline BMI, LDL-C, and total-cholesterol levels. Conclusions: Generally, successful HCV eradication by IFN-free-DAAs decreases CAP and LDL-C in patients with high baseline values. However, elevated LDL-C was accompanied with elevated sdLDL-C only in patients with liver steatosis and dyslipidemia at SVR24; therefore, those patients may require closer monitoring.

Published
2018

47. Case with long-standing gout showing various ultrasonographic features caused by monosodium urate monohydrate crystal deposition.

Author

Murayama, Michito, Nishida, Mutsumi, Kudo, Yusuke, Deguchi, Takahiro, Marukawa, Katsuji, Fujieda, Yuichiro, Abe, Nobuya, Kato, Masaru, Shibuya, Hitoshi, Matsuno, Yoshihiro, and Atsumi, Tatsuya

Subjects
SYNOVIAL fluid, ULTRASONIC imaging, GOUT diagnosis, PATIENTS, ARTHRITIS
Abstract

Gout, which is characterized by the deposition of monosodium urate monohydrate (MSU) in the synovial fluid and other tissues, is the most common form of inflammatory arthritis. Unlike the easily recognized acute and monoarticular gouty arthritis, advanced gout induces multiple finger joint disorders and may sometimes mimic rheumatoid arthritis (RA) or vice versa. The gold standard for gout diagnosis is the identification of MSU crystals via aspiration in the symptomatic joints or nodules; however, its feasibility and specificity may be inadequate. Recently, there have been important advances in imaging techniques, assisting in the non-invasive diagnosis of gout. Ultrasonography (US) has been known to have the ability to detect deposition of MSU crystals in patients with gout. Herein, we report an evocative case of long-standing gout with precisely detected specific US features indicating MSU crystal deposition and inflammation in multiple joints. Comprehensive US assessment included the bone, hyaline cartilage, soft tissue, subcutaneous nodules and tendon; we also discriminated gouty arthritis from RA. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Corelation between Organic Electroluminescent Characteristics and Surface Composition of Oxygen-Plasma treated Indium-Tin-Oxide

Author

Kudo, Yusuke and Kusabiraki, Minoru

Subjects
O_2-plasma treatment, Organic EL device, Operating voltage, XPS spectra, digestive system, ITO
Abstract

Organic electroluminescent (EL) device was fabricated on the oxygen (0_2) - plasma treated indiumtin-oxide (ITO) surface. The corelation between the device performance and the chemical composition of the 0_2-plasma treated ITO surface was investigated. The operating voltage of the devices were decreased by 0_2-plasma exposure. This reduction is due to the change of surface composition with exposure time.

Published
2004

49. The Effectiveness of Noninvasive Transabdominal Ultrasound Evaluation in the Diagnosis of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

Author

Nishida, Mutsumi, primary, Kahata, Kaoru, additional, Sato, Megumi, additional, Kudo, Yusuke, additional, Omotehara, Satomi, additional, Iwai, Takahito, additional, Iguchi, Akihiro, additional, Sugita, Junichi, additional, Teshima, Takanori, additional, and Shimizu, Chikara, additional

Published
2017
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50. User Generated Agent

Author

Kudo, Yusuke, primary, Kayano, Wataru, additional, Sato, Takuya, additional, and Osawa, Hirotaka, additional

Published
2016
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