Search

Your search keyword '"Kucuk, Mutlu"' showing total 28 results
Start Over Author "Kucuk, Mutlu"
28 results on '"Kucuk, Mutlu"'

5. Targeted delivery of lacosamide-conjugated gold nanoparticles into the brain in temporal lobe epilepsy in rats

Author

Yilmaz, Canan Ugur, Emik, Serkan, Orhan, Nurcan, Temizyurek, Arzu, Atis, Muge, Akcan, Ugur, Khodadust, Rouhollah, Arican, Nadir, Kucuk, Mutlu, Gurses, Candan, Ahishali, Bulent, Kaya, Mehmet, Yilmaz, Canan Ugur, Emik, Serkan, Orhan, Nurcan, Temizyurek, Arzu, Atis, Muge, Akcan, Ugur, Khodadust, Rouhollah, Arican, Nadir, Kucuk, Mutlu, Gurses, Candan, Ahishali, Bulent, and Kaya, Mehmet

Abstract

Temporal lobe epilepsy (TLE) is the most common form of epilepsy with focal seizures, and currently available drugs may fail to provide a thorough treatment of the patients. The present study demonstrates the utility of glucose-coated gold nanoparticles (GNPs) as selective carriers of an antiepileptic drug, lacosamide (LCM), in developing a strategy to cross the blood-brain barrier to overcome drug resistance. Intravenous administration of LCM-loaded GNPs to epileptic animals yielded significantly higher nanoparticle levels in the hippocampus compared to the nanoparticle administration to intact animals. The amplitude and frequency of EEG-waves in both ictal and interictal stages decreased significantly after LCM-GNP administration to animals with TLE, while a decrease in the number of seizures was also observed though statistically insignificant. In these animals, malondialdehyde was unaffected, and glutathione levels were lower in the hippocampus compared to sham. Ultrastructurally, LCM-GNPs were observed in the brain parenchyma after intravenous injection to animals with TLE. We conclude that glucose-coated GNPs can be efficient in transferring effective doses of LCM into the brain enabling elimination of the need to administer high doses of the drug, and hence, may represent a new approach in the treatment of drug-resistant TLE.

Published
2020
Full Text
View/download PDF

22. Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia

Author

Gurses, Candan, primary, Ekizoglu, Oguzhan, additional, Orhan, Nurcan, additional, Ustek, Duran, additional, Arican, Nadir, additional, Ahishali, Bulent, additional, Elmas, Imdat, additional, Kucuk, Mutlu, additional, Bilgic, Bilge, additional, Kemikler, Gonul, additional, Kalayci, Rivaze, additional, Karadeniz, Ahmet, additional, and Kaya, Mehmet, additional

Published
2009
Full Text
View/download PDF

23. Morphological and functional changes of blood–brain barrier in kindled rats with cortical dysplasia

Author

Kaya, Mehmet, primary, Gurses, Candan, additional, Kalayci, Rivaze, additional, Ekizoglu, Oguzhan, additional, Ahishali, Bulent, additional, Orhan, Nurcan, additional, Oku, Basar, additional, Arican, Nadir, additional, Ustek, Duran, additional, Bilgic, Bilge, additional, Elmas, Imdat, additional, Kucuk, Mutlu, additional, and Kemikler, Gonul, additional

Published
2008
Full Text
View/download PDF

25. Effects of lipopolysaccharide on the radiation-induced changes in the blood–brain barrier and the astrocytes

Author

Kaya, Mehmet, primary, Palanduz, Ayse, additional, Kalayci, Rivaze, additional, Kemikler, Gonul, additional, Simsek, Gonul, additional, Bilgic, Bilge, additional, Ahishali, Bulent, additional, Arican, Nadir, additional, Kocyildiz, Zuhal Celebi, additional, Elmas, Imdat, additional, Kucuk, Mutlu, additional, and Karadeniz, Ahmet, additional

Published
2004
Full Text
View/download PDF

28. Catalase andα-tocopherol attenuate blood–brain barrier breakdown in pentylenetetrazole-induced epileptic seizures in acute hyperglycaemic rats

Author

Kaya, Mehmet, Cimen, Vedat, Kalayci, Rivaze, Kucuk, Mutlu, Gurses, Candan, Arican, Nadir, and Elmas, Imdat

Subjects
*BLOOD-brain barrier, *HYPERGLYCEMIA, *VITAMIN E, *CATALASE
Abstract

Experimental data indicate that acute hyperglycaemia can aggravate the consequences of epileptic seizures on the permeability of the blood–brain barrier (BBB). The purpose of this study was to examine the effects of chronic administration of α -tocopherol (vitamin E) and acute catalase administration on the disrupted BBB during experimentally pentylenetetrazole-induced status epilepticus in acute hyperglycaemic rats. The integrity of the BBB was tested using the Evans Blue (EB) dye extravasation. The concentration of EB dye was measured in four regions of the brain. Epileptic seizures induced a significant increase in EB dye extravasation in the brain regions compared with that of the groups of rats treated with saline, glucose, catalase and α -tocopherol (P< 0.01). The content of EB dye in the brain regions of animals in the acute hyperglycaemia plus epileptic group was higher than that of the saline, glucose, catalase, α -tocopherol and epileptic groups (P< 0.01). The increased EB dye transfer from blood to the brain in status epilepticus and acute hyperglycaemia plus status epilepticus was attenuated by the treatment with catalase and α -tocopherol. These data suggest that a partial reduction in the production of reactive oxygen species by catalase and α -tocopherol contributes to decreases in the content of EB dye across the BBB during pentylenetetrazole-induced status epilepticus in acute hyperglycaemic rats. [Copyright &y& Elsevier]

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results