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9 results on '"Kucera, Gary"'

5. Concentration-Dependent Recruitment of Mammalian Odorant Receptors

Author

Hu, Xiaoyang Serene, primary, Ikegami, Kentaro, additional, Vihani, Aashutosh, additional, Zhu, Kevin W., additional, Zapata, Marcelo, additional, de March, Claire A., additional, Do, Matthew, additional, Vaidya, Natasha, additional, Kucera, Gary, additional, Bock, Cheryl, additional, Jiang, Yue, additional, Yohda, Masafumi, additional, and Matsunami, Hiroaki, additional

Published
2020
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6. Overexpression of an agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants

Author

Kucera, Gary T., Bortner, Donna M., and Rosenberg, Michael P.

Subjects
Genetically modified mice -- Research, Color of animals -- Genetic aspects, Obesity -- Genetic aspects, Diabetes -- Genetic aspects, Biological sciences
Abstract

Expression of the classical Agouti gene cause mice to vary in their coat phenotype by regulating the synthesis of the yellow pigment phaeomelanin. However, information about the effects of the overexpression of this gene is lacking. In this study, the agoutic protein was expressed in high levels in the skin of transgenic mice to determine whether it can cause obesity and diabetes. The mice showed no changes that could be linked to obesity or hyperglycemia. However, many founder mice exhibited coat color patterns that resembled the agouti allele responsible for the variegated or striped phenotype. These results suggest that the agouti gene has no endocrine function.

Published
1996

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