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344 results on '"Kubota, Toshiaki"'

1. Association of the CYP39A1 G204E Genetic Variant with Increased Risk of Glaucoma and Blindness in Patients with Exfoliation Syndrome

Author

Bell, Katharina, Ozaki, Mineo, Mori, Kazuhiko, Mizoguchi, Takanori, Nakano, Satoko, Porporato, Natalia, Ikeda, Yoko, Chihara, Etsuo, Inoue, Kenji, Manabe, Shinichi, Hayashi, Ken, Higashide, Tomomi, Ideta, Ryuichi, Tokumo, Kana, Kiuchi, Yoshiaki, Nakano, Masakazu, Ueno, Morio, Kinoshita, Shigeru, Tashiro, Kei, Sotozono, Chie, Inatani, Masaru, Sugiyama, Kazuhisa, Kubota, Toshiaki, Li, Zheng, Wang, Zhenxun, Khor, Chiea Chuen, and Aung, Tin

Published
2022
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7. Successful Treatment of Hemi-Retinal Vein Occlusion with Macular Edema following Spinal Surgery Using Intravitreal Aflibercept and Retinal Photocoagulation: A Case Report.

Author

Nakatake, Shunji, Sato, Yoshiki, Itotani, Maho, Kimoto, Kenichi, Kubota, Toshiaki, and Takeda, Atsunobu

Subjects
RETINAL vein occlusion, RETINAL surgery, LASER photocoagulation, SPINAL surgery, MACULAR edema, TREATMENT effectiveness, AFLIBERCEPT, LIGHT coagulation
Abstract

Introduction: Perioperative visual loss (POVL) owing to hemi-retinal vein occlusion (HRVO) following prone positioning during spinal surgery is rare. Here, we report a case of HRVO with macular edema (ME) after spinal surgery that was successfully treated with intravitreal aflibercept (IVA) injections and retinal photocoagulation (RP). Case Presentation: A 63-year-old Japanese man underwent spinal surgery for lumbar spinal canal stenosis. Surgery was performed with the patient in the prone position under general anesthesia; the operation time was 305 min. No complications were associated with intraoperative anesthesia. On postoperative day 4, the patient noticed decreased visual acuity in his left eye and visited the Department of Ophthalmology on postoperative day 9. The best-corrected visual acuity (BCVA) in the left eye was 0.1. Fundus and optical coherence tomography revealed HRVO and ME in the left eye. IVA injections and RP were performed in the eye, which substantially decreased the ME and improved the patient's BCVA to 0.8. Conclusions: HRVO can cause POVL after prone positioning during spinal surgery. This is the first case of HRVO with ME after spinal surgery, which was successfully treated with IVA injections and RP. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Associations of Diabetic Retinopathy Severity With High Ambulatory Blood Pressure and Suppressed Serum Renin Levels

Author

Sada, Kentaro, primary, Yoshida, Yuichi, additional, Shibuta, Kanako, additional, Kimoto, Kenichi, additional, Miyamoto, Shotaro, additional, Ozeki, Yoshinori, additional, Okamoto, Mitsuhiro, additional, Gotoh, Koro, additional, Masaki, Takayuki, additional, Yokoyama, Katsuhiko, additional, Kubota, Toshiaki, additional, and Shibata, Hirotaka, additional

Published
2023
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10. Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study

Author

Fujiwara, Kohta, Ueda, Emi, Hata, Jun, Nakano, Satoko, Hashimoto, Sawako, Nakamura, Shun, Murakami, Yusuke, Kubota, Toshiaki, Yoshitomi, Takeshi, Ninomiya, Toshiharu, and Sonoda, Koh-Hei

Abstract

AimsTo investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population.MethodsWe analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of corneal hysteresis, which had been measured with an ocular response analyzer. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. We conducted a logistic regression analysis to determine the ORs and their 95% CIs for the presence of outcomes according to the corneal hysteresis quartiles.ResultsGlaucoma was diagnosed in 154 participants: primary open-angle glaucoma (POAG), n=115; primary angle-closure glaucoma, n=17; exfoliation glaucoma, n=21 and secondary glaucoma without exfoliation glaucoma, n=1. After adjustment for confounders, the OR for prevalent glaucoma was significantly increased in the participants in the first corneal-hysteresis quartile compared with those in the fourth quartile (OR: 1.80; 95% CI: 1.03 to 3.17). Regarding glaucoma subtypes, the first-quartile participants had significantly greater likelihoods of the presence of POAG (OR: 1.63; 95% CI: 1.02 to 2.61) and exfoliation glaucoma (OR: 6.49; 95% CI: 1.44 to 29.30) compared with those in the third and fourth quartiles after adjustment for potential confounders.ConclusionsThese results demonstrated a significant inverse association between corneal hysteresis and the likelihood of glaucoma, suggesting that the measurement of corneal hysteresis would provide useful information for elucidating the aetiology of glaucoma.

Published
2024
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11. Prevalence of Glaucoma and Its Systemic Risk Factors in a General Japanese Population: The Hisayama Study

Author

Fujiwara, Kohta, primary, Yasuda, Miho, additional, Hata, Jun, additional, Nakano, Satoko, additional, Hashimoto, Sawako, additional, Ueda, Emi, additional, Nakamura, Shun, additional, Murakami, Yusuke, additional, Nakamuro, Takako, additional, Iwase, Aiko, additional, Araie, Makoto, additional, Tawara, Akihiko, additional, Kubota, Toshiaki, additional, Yoshitomi, Takeshi, additional, Ninomiya, Toshiharu, additional, and Sonoda, Koh-Hei, additional

Published
2022
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13. Efficacy of predetermined therapeutic measures against bleb‐related infection in the Collaborative Bleb‐related Infection Incidence and Treatment Study

Author

Shoji, Nobuyuki, Arakaki, Yoshikuni, Nakamoto, Kenji, Yamamoto, Tetsuya, Kuwayama, Yasuaki, Aoyama, Yumiko, Kawase, Kazuhide, Ban, Takahiro, Sawada, Akira, Mochizuki, Kiyofumi, Futa, Ryusuke, Yasuda, Noriko, Nakajima, Masayuki, Sugiyama, Tetsuya, Kojima, Shota, Hirotsuji, Norihiko, Kano, Kiyoshi, Ohura, Atsushi, Kawai, Eriko, Nakata, Atsuko, Kuwamura, Rika, Okuno, Kensuke, Yawata, Kenji, Matsumoto, Shun, Abe, Haruki, Fukuchi, Takeo, Shirakashi, Motohiro, Ueda, Jun, Tanaka, Takayuki, Negi, Akira, Nakamura, Makoto, Kanamori, Akiyasu, Yamada, Yuko, Tawara, Akihiko, Kubota, Toshiaki, Tou, Norihiko, Kimura, Tairo, Furusawa, Chiaki, Inoue, Naoki, Kawabata, Kiho, Tachibana, Nobuhiko, Matsuda, Akira, Seto, Takahiko, Kimura, Satoshi, Ueno, Satoki, Tokuda, Naoto, Inoue, Jun, Sugiyama, Kazuhisa, Ohkubo, Shinji, Higashide, Tomomi, Saito, Yoshiaki, Takeda, Hisashi, Nagata, Atsushi, Uji, Yukitaka, Tsukitome, Hideyuki, Ito, Kunio, Ikesugi, Kengo, Matsumura, Miyo, Nambu, Hiroyuki, Hamanaka, Teruhiko, Omata, Takayasu, Watanabe, Yukiko, Sakuma, Keiko, Amari, Yoko, Takahashi, Genichiro, Noro, Takahiko, Miyata, Hiroshi, Hirasawa, Manabu, Ohtake, Yuichiro, Yuki, Kenya, Araie, Makoto, Tomita, Goji, Aihara, Makoto, Tomidokoro, Atsuo, Matsuo, Hiroshi, Atarashi, Takuya, Mayama, Chihiro, Yamagami, Junkichi, Okinami, Satoshi, Ishikawa, Shinichiro, Morita, Tetsuya, Otsuki, Tomohiro, Suzuki, Hiromasa, Naruse, Ryoko, Yamakawa, Yayoi, Kasahara, Masayuki, Yoshitomi, Takeshi, Kashiwagi, Kenji, Mabuchi, Fumihiko, Chiba, Tatsuya, Suzuki, Yasuyuki, Shimizu, Satoko, Mishima, Hiromu K, Kiuchi, Yoshiaki, Mochizuki, Hideki, Sone, Takashi, Tsukamoto, Hidetoshi, Okada, Koji, Sawaguchi, Shoichi, Sakai, Hiroshi, Ishikawa, Shusaku, Tanihara, Hidenobu, Inatani, Masaru, Inoue, Toshihiro, Koga, Takahisa, Aoyama, Akira, Yamazaki, Yoshio, Okajima, Yasuhiko, Mizuki, Kenji, Hayamizu, Fukuko, Nakagami, Takako, Mori, Kazuhiko, Ikeda, Yoko, Ueno, Morio, Imai, Kojiro, Suzumura, Hirotaka, Kawai, Kenji, Sueno, Toshiharu, Saito, Nobuo, Otori, Yasumasa, Iwase, Aiko, Katsushima, Harumi, Kitazawa, Yoshiaki, Shimizu, Hiroshi, Shirato, Shiroaki, Matsumoto, Chota, Yoshikawa, Keiji, Inoue, Yoshitsugu, Kondo, Akira, and Yamamoto, Kimiko

Published
2018
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14. Branch Retinal Artery Occlusions, Paracentral Acute Middle Maculopathy and Acute Macular Neuroretinopathy After COVID-19 Vaccinations

Author

Ishibashi,Koki, Yatsuka,Hiroyuki, Haruta,Masatoshi, Kimoto,Kenichi, Yoshida,Shigeo, Kubota,Toshiaki, Ishibashi,Koki, Yatsuka,Hiroyuki, Haruta,Masatoshi, Kimoto,Kenichi, Yoshida,Shigeo, and Kubota,Toshiaki

Abstract

Koki Ishibashi,1,2 Hiroyuki Yatsuka,3 Masatoshi Haruta,1 Kenichi Kimoto,3 Shigeo Yoshida,1 Toshiaki Kubota3 1Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan; 2Department of Ophthalmology, Yame General Hospital, Yame, Japan; 3Department of Ophthalmology, Faculty of Medicine, Oita University, Yufu, JapanCorrespondence: Masatoshi Haruta, Department of Ophthalmology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan, Tel +81 942 31 7574, Fax +81 942 37 0324, Email haruta_masatoshi@med.kurume-u.ac.jpPurpose: Potential retinal adverse events after COVID-19 vaccinations reported previously include paracentral acute middle maculopathy (PAMM), acute macular neuroretinopathy (AMN), and central serous chorioretinopathy. We report four cases of branch retinal artery occlusion (BRAO), one case of PAMM, and one case of AMN that occurred after administration of the Pfizer-BioNTech COVID-19 vaccine.Patients and Methods: We retrospectively reviewed the medical records of six patients who presented to Yame General Hospital or Oita University Hospital from July through October 2021.Results: Four patients (2 males) presented with visual field defects associated with BRAO, one male patient with PAMM, and one female patient with AMN after receiving the Pfizer-BioNTech COVID-19 vaccine. The mean age was 59.3 years; the mean best-corrected visual acuity was 20/21. The mean time from the last vaccination to the onset of visual field defect was 22.8 days. Five patients had received two doses of the vaccine and one patient one dose. Patients’ medical history included diabetes mellitus in case 2, hypertension in cases 2, 3 and 6, and Alport syndrome and end-stage renal disease in case 6 for which the patient was undergoing regular hemodialysis.Conclusion: Although rare, retinal adverse events may occur after COVID-19 vaccinations. Further studies with a larger sample size should determine whether these retinal abnormalitie

Published
2022

18. Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus

Author

Hauser, Michael A., Aboobakar, Inas F., Liu, Yutao, Miura, Shiroh, Whigham, Benjamin T., Challa, Pratap, Wheeler, Joshua, Williams, Andrew, Santiago-Turla, Cecelia, Qin, Xuejun, Rautenbach, Robyn M., Ziskind, Ari, Ramsay, Michèle, Uebe, Steffen, Song, Lingyun, Safi, Alexias, Vithana, Eranga N., Mizoguchi, Takanori, Nakano, Satoko, Kubota, Toshiaki, Hayashi, Ken, Manabe, Shin-ichi, Kazama, Shigeyasu, Mori, Yosai, Miyata, Kazunori, Yoshimura, Nagahisa, Reis, Andre, Crawford, Gregory E., Pasutto, Francesca, Carmichael, Trevor R., Williams, Susan E. I., Ozaki, Mineo, Aung, Tin, Khor, Chiea-Chuen, Stamer, W. Daniel, Ashley-Koch, Allison E., and Allingham, R. Rand

Published
2015
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20. Association of Rare CYP39A1 Variants with Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Author

Li, Zheng, Wang, Zhenxun, Lee, Mei Chin, Zenkel, Matthias, Peh, Esther, Ozaki, Mineo, Topouzis, Fotis, Nakano, Satoko, Chan, Anita, Chen, Shuwen, Williams, Susan E.I., Orr, Andrew, Nakano, Masakazu, Kobakhidze, Nino, Zarnowski, Tomasz, Popa-Cherecheanu, Alina, Mizoguchi, Takanori, Manabe, Shin Ichi, Hayashi, Ken, Kazama, Shigeyasu, Inoue, Kenji, Mori, Yosai, Miyata, Kazunori, Sugiyama, Kazuhisa, Higashide, Tomomi, Chihara, Etsuo, Ideta, Ryuichi, Ishiko, Satoshi, Yoshida, Akitoshi, Tokumo, Kana, Kiuchi, Yoshiaki, Ohashi, Tsutomu, Sakurai, Toshiya, Sugimoto, Takako, Chuman, Hideki, Aihara, Makoto, Inatani, Masaru, Mori, Kazuhiko, Ikeda, Yoko, Ueno, Morio, Gaston, Daniel, Rafuse, Paul, Shuba, Lesya, Saunders, Joseph, Nicolela, Marcelo, Chichua, George, Tabagari, Sergo, Founti, Panayiota, Sim, Kar Seng, Meah, Wee Yang, Soo, Hui Meng, Chen, Xiao Yin, Chatzikyriakidou, Anthi, Keskini, Christina, Pappas, Theofanis, Anastasopoulos, Eleftherios, Lambropoulos, Alexandros, Panagiotou, Evangelia S., Mikropoulos, Dimitrios G., Kosior-Jarecka, Ewa, Cheong, Augustine, Li, Yuanhan, Lukasik, Urszula, Nongpiur, Monisha E., Husain, Rahat, Perera, Shamira A., Álvarez, Lydia, García, Montserrat, González-Iglesias, Héctor, Cueto, Andrés F.V., Cueto, Luis F.V., Martinón-Torres, Federico, Salas, Antonio, Oguz, Çilingir, Tamcelik, Nevbahar, Atalay, Eray, Batu, Bilge, Irkec, Murat, Aktas, Dilek, Kasim, Burcu, Astakhov, Yury S., Astakhov, Sergei Y., Akopov, Eugeny L., Giessl, Andreas, Mardin, Christian, Hellerbrand, Claus, Cooke Bailey, Jessica N., Igo, Robert P., Haines, Jonathan L., Edward, Deepak P., Heegaard, Steffen, Davila, Sonia, Tan, Patrick, Kang, Jae H., Pasquale, Louis R., Kruse, Friedrich E., Reis, André, Carmichael, Trevor R., Hauser, Michael, Ramsay, Michele, Mossböck, Georg, Yildirim, Nilgun, Tashiro, Kei, Konstas, Anastasios G.P., Coca-Prados, Miguel, Foo, Jia Nee, Kinoshita, Shigeru, Sotozono, Chie, Kubota, Toshiaki, Dubina, Michael, Ritch, Robert, Wiggs, Janey L., Pasutto, Francesca, Schlötzer-Schrehardt, Ursula, Ho, Ying Swan, Aung, Tin, Tam, Wai Leong, Khor, Chiea Chuen, Li, Zheng, Wang, Zhenxun, Lee, Mei Chin, Zenkel, Matthias, Peh, Esther, Ozaki, Mineo, Topouzis, Fotis, Nakano, Satoko, Chan, Anita, Chen, Shuwen, Williams, Susan E.I., Orr, Andrew, Nakano, Masakazu, Kobakhidze, Nino, Zarnowski, Tomasz, Popa-Cherecheanu, Alina, Mizoguchi, Takanori, Manabe, Shin Ichi, Hayashi, Ken, Kazama, Shigeyasu, Inoue, Kenji, Mori, Yosai, Miyata, Kazunori, Sugiyama, Kazuhisa, Higashide, Tomomi, Chihara, Etsuo, Ideta, Ryuichi, Ishiko, Satoshi, Yoshida, Akitoshi, Tokumo, Kana, Kiuchi, Yoshiaki, Ohashi, Tsutomu, Sakurai, Toshiya, Sugimoto, Takako, Chuman, Hideki, Aihara, Makoto, Inatani, Masaru, Mori, Kazuhiko, Ikeda, Yoko, Ueno, Morio, Gaston, Daniel, Rafuse, Paul, Shuba, Lesya, Saunders, Joseph, Nicolela, Marcelo, Chichua, George, Tabagari, Sergo, Founti, Panayiota, Sim, Kar Seng, Meah, Wee Yang, Soo, Hui Meng, Chen, Xiao Yin, Chatzikyriakidou, Anthi, Keskini, Christina, Pappas, Theofanis, Anastasopoulos, Eleftherios, Lambropoulos, Alexandros, Panagiotou, Evangelia S., Mikropoulos, Dimitrios G., Kosior-Jarecka, Ewa, Cheong, Augustine, Li, Yuanhan, Lukasik, Urszula, Nongpiur, Monisha E., Husain, Rahat, Perera, Shamira A., Álvarez, Lydia, García, Montserrat, González-Iglesias, Héctor, Cueto, Andrés F.V., Cueto, Luis F.V., Martinón-Torres, Federico, Salas, Antonio, Oguz, Çilingir, Tamcelik, Nevbahar, Atalay, Eray, Batu, Bilge, Irkec, Murat, Aktas, Dilek, Kasim, Burcu, Astakhov, Yury S., Astakhov, Sergei Y., Akopov, Eugeny L., Giessl, Andreas, Mardin, Christian, Hellerbrand, Claus, Cooke Bailey, Jessica N., Igo, Robert P., Haines, Jonathan L., Edward, Deepak P., Heegaard, Steffen, Davila, Sonia, Tan, Patrick, Kang, Jae H., Pasquale, Louis R., Kruse, Friedrich E., Reis, André, Carmichael, Trevor R., Hauser, Michael, Ramsay, Michele, Mossböck, Georg, Yildirim, Nilgun, Tashiro, Kei, Konstas, Anastasios G.P., Coca-Prados, Miguel, Foo, Jia Nee, Kinoshita, Shigeru, Sotozono, Chie, Kubota, Toshiaki, Dubina, Michael, Ritch, Robert, Wiggs, Janey L., Pasutto, Francesca, Schlötzer-Schrehardt, Ursula, Ho, Ying Swan, Aung, Tin, Tam, Wai Leong, and Khor, Chiea Chuen

Abstract

Importance: Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness. Objective: To determine if exfoliation syndrome is associated with rare, protein-changing variants predicted to impair protein function. Design, Setting, and Participants: A 2-stage, case-control, whole-exome sequencing association study with a discovery cohort and 2 independently ascertained validation cohorts. Study participants from 14 countries were enrolled between February 1999 and December 2019. The date of last clinical follow-up was December 2019. Affected individuals had exfoliation material on anterior segment structures of at least 1 eye as visualized by slit lamp examination. Unaffected individuals had no signs of exfoliation syndrome. Exposures: Rare, coding-sequence genetic variants predicted to be damaging by bioinformatic algorithms trained to recognize alterations that impair protein function. Main Outcomes and Measures: The primary outcome was the presence of exfoliation syndrome. Exome-wide significance for detected variants was defined as P < 2.5 × 10-6. The secondary outcomes included biochemical enzymatic assays and gene expression analyses. Results: The discovery cohort included 4028 participants with exfoliation syndrome (median age, 78 years [interquartile range, 73-83 years]; 2377 [59.0%] women) and 5638 participants without exfoliation syndrome (median age, 72 years [interquartile range, 65-78 years]; 3159 [56.0%] women). In the discovery cohort, persons with exfoliation syndrome, compared with those without exfoliation syndrome, were significantly more likely to carry damaging CYP39A1 variants (1.3% vs 0.30%, respectively; odds ratio, 3.55 [95% CI, 2.07-6.10]; P = 6.1 × 10-7). This outcome was validated in 2 independent cohorts. The fi

Published
2021

28. Corrigendum to “Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish”

Author

Yatsuka, Hiroyuki, primary, Hada, Kazumasa, additional, Shiraishi, Hiroshi, additional, Umeda, Ryohei, additional, Morisaki, Ikuko, additional, Urushibata, Hirotaro, additional, Shimizu, Nobuyuki, additional, Sebastian, Wulan Apridita, additional, Hikida, Takatoshi, additional, Ishitani, Tohru, additional, Hanada, Reiko, additional, Shimada, Tatsuo, additional, Kimoto, Kenichi, additional, Kubota, Toshiaki, additional, and Hanada, Toshikatsu, additional

Published
2021
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