681 results on '"Kubota, Toru"'
Search Results
2. Severe mitral regurgitation in chronic adult T-cell leukemia/lymphoma with granulomatous valvular inflammation
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Sunagawa, Genya, Kato, Seiya, Sukehiro, Yuta, Minematsu, Noritoshi, Nagatomo, Daisuke, Nozoe, Masatsugu, Oi, Keiji, Ohshima, Koichi, Suematsu, Nobuhiro, and Kubota, Toru
- Subjects
Case Report ,Cardiology and Cardiovascular Medicine - Abstract
Adult T-cell leukemia/lymphoma (ATLL) is a mature peripheral T-cell neoplasm caused by human T-cell leukemia virus type I (HTLV-1) infection. Besides the oncogenic property, HTLV-1 causes HTLV-1-associated myelopathy/tropical spastic paraparesis and certain inflammatory diseases via a complex host immune response to latent virus infection. Cardiac involvement of ATLL is rare, with the majority of cases being disclosed in postmortem autopsy in patients with advanced subtypes. We herein report the case of a 64-year-old female patient with indolent chronic ATLL with severe mitral regurgitation. Although the condition of ATLL was stable, dyspnea on exertion gradually progressed over the course of three years and echocardiography revealed marked thickening of the mitral valve. Finally, the patient experienced hemodynamic collapse with atrial fibrillation and underwent surgical valve replacement. The removed mitral valve was grossly edematous and swollen. A histological examination revealed a granulomatous reaction mimicking the active phase of rheumatic valvulitis, with the infiltration of ATLL cells that were immunohistochemically positive for CD3, CD4, FoxP3, HLA-DRα, and CCR4. The postoperative course was uneventful, with the exception that Sjögren's syndrome was noted. The history of rheumatic fever was unclear, and such unique valvular pathology was presumably related to autoimmune mechanisms associated with HTLV-1 infection. LEARNING OBJECTIVE: We report a case of chronic adult T-cell leukemia/lymphoma (ATLL) with isolated valvular infiltration with a unique histology of granulomatous reaction. Human T-cell leukemia virus type I infection may accelerate autoimmune reactions and cardiac inflammation, irrespective of indolent clinical subtype. Among ATLL cases, possible progression of valvular insufficiency and heart failure in patients with cardiac symptoms should be carefully evaluated.
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- 2023
3. Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α
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Higuchi, Yoshihiro, Niidome, Takuro, Miyamoto, Yuji, Komohara, Yoshihiro, Tokunou, Tomotake, Kubota, Toru, and Horiuchi, Takahiko
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- 2019
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4. Left sinus of Valsalva aneurysm causing acute myocardial infarction with compression of the left main coronary trunk.
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Mizokami, Genryu, Nozoe, Masatsugu, Kato, Seiya, Nagatomo, Daisuke, Suematsu, Nobuhiro, Sukehiro, Yuta, Minematsu, Noritoshi, Sakata, Satoko, and Kubota, Toru
- Abstract
Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly that commonly originates from the right or noncoronary sinuses and rarely from the left sinus. SVA is usually diagnosed in the setting of clinical sequelae of a rupture. We herein report a case of an unruptured left SVA presenting as acute myocardial infarction. A 54-year-old woman with a history of radical operation for patent ductus arteriosus in childhood was transferred to our hospital. An electrocardiogram indicated extensive myocardial ischemia with ST elevation. Urgent coronary angiography was performed but was unable to identify the left coronary artery. Subsequent aortography and computed tomography revealed a large SVA originating from the left sinus and compressing the left coronary artery. The patient died after approximately one month of intensive care, including mechanical circulatory support and coronary artery bypass grafting. Autopsy confirmed that the left main coronary trunk was stretched and compressed by the SVA and revealed unexpected atherosclerosis in the left anterior descending artery. Although a left SVA is an extremely rare anomaly, it occasionally provokes fatal myocardial infarction. Since an SVA might hinder performing percutaneous coronary intervention, cardiac surgery should be considered when myocardial ischemia is recognized. We herein report a case of an unruptured left sinus of Valsalva aneurysm (SVA) with acute myocardial infarction. Urgent percutaneous coronary intervention (PCI) was unsuccessful, as the left coronary artery was compressed by the SVA. The patient died after intensive care, including coronary artery bypass grafting (CABG). SVA, especially from the left sinus, is extremely rare but occasionally provokes myocardial infarction by compressing the coronary arteries. Because SVA might hinder PCI, CABG should be considered when myocardial ischemia is recognized. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Abstract 13306: Impella Combined With Extracorporeal Membrane Oxygenation Synergistically Unloads the Left Ventricle and Reduces Infarct Size in a Model of Myocardial Infarction With Cardiogenic Shock
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Sunagawa, Genya, Saku, Keita, Nishikawa, Takuya, Suematsu, Nobuhiro, Kubota, Toru, Sunagawa, Kenji, and Tsutsui, Hiroyuki
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- 2020
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6. Increased pain after palliative radiotherapy: not only due to cancer progression
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Murakami, Satoshi, primary, Kitani, Akira, additional, Kubota, Toru, additional, and Uezono, Yasuhito, additional
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- 2023
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7. Severe mitral regurgitation in chronic adult T-cell leukemia/lymphoma with granulomatous valvular inflammation
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Sunagawa, Genya, primary, Kato, Seiya, additional, Sukehiro, Yuta, additional, Minematsu, Noritoshi, additional, Nagatomo, Daisuke, additional, Nozoe, Masatsugu, additional, Oi, Keiji, additional, Ohshima, Koichi, additional, Suematsu, Nobuhiro, additional, and Kubota, Toru, additional
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- 2022
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8. Efficacy and safety of the early use of V2 receptor antagonists in elderly patients with decompensated heart failure
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Matsukawa, Ryuichi, Kubota, Toru, Okabe, Masanori, Yamamoto, Yusuke, and Meno, Hiroshi
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- 2017
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9. Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation
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Kanaoka, Koshiro, primary, Onoue, Kenji, additional, Terasaki, Satoshi, additional, Nakano, Tomoya, additional, Nakai, Michikazu, additional, Sumita, Yoko, additional, Hatakeyama, Kinta, additional, Terasaki, Fumio, additional, Kawakami, Rika, additional, Iwanaga, Yoshitaka, additional, Miyamoto, Yoshihiro, additional, Saito, Yoshihiko, additional, Yuda, Satoshi, additional, Tanno, Masaya, additional, Takahashi, Toru, additional, Yokoshiki, Hisashi, additional, Toba, Masahiro, additional, Anzai, Toshihisa, additional, Nagai, Toshiyuki, additional, Sato, Takuma, additional, Takenaka, Takashi, additional, Yamazaki, Seiji, additional, Katagiri, Yuki, additional, Takeuchi, Toshiharu, additional, Sugitatsu, Kazuya, additional, Kakinoki, Shigeo, additional, Matsumoto, Tomoaki, additional, Urasawa, Kazushi, additional, Tan, Michinao, additional, Tsujino, Ichizo, additional, Kamigaki, Mitsunori, additional, Tomita, Hirofumi, additional, Hanada, Kenji, additional, Kushibiki, Motoi, additional, Nakamura, Akihiro, additional, Morino, Yoshihiro, additional, Nasu, Takahito, additional, Yasuda, Satoshi, additional, Suzuki, Hideaki, additional, Iwabuchi, Kaoru, additional, Tsuji, Kanako, additional, Namiuchi, Shigeto, additional, Komaru, Tatsuya, additional, Yagi, Masahiro, additional, Uematsu, Shoko, additional, Takahashi, Toshiaki, additional, Takeda, Satoru, additional, Nakanishi, Toru, additional, Watanabe, Masafumi, additional, Wanezaki, Masahiro, additional, Matsui, Motoyuki, additional, Sugawara, Shigeo, additional, Takeishi, Yasuchika, additional, Oikawa, Masayoshi, additional, Komatsu, Nobuo, additional, Suzuki, Satoshi, additional, Okamoto, Hiroshi, additional, Takeyasu, Noriyuki, additional, Akiyama, Daiki, additional, Eki, Yutaka, additional, Kakuta, Tsunekazu, additional, Sugiyama, Tomoyo, additional, Koizumi, Tomomi, additional, Ueno, Koji, additional, Kario, Kazuomi, additional, Taki, Mizuri, additional, Matsumoto, Yuri, additional, Yasu, Takanori, additional, Nishioka, Osamu, additional, Naito, Shigeto, additional, Murata, Makoto, additional, Tange, Shoichi, additional, Kaneko, Katsumi, additional, Muto, Makoto, additional, Inagaki, Hiroshi, additional, Hasegawa, Shuichi, additional, Tachibana, Eizo, additional, Atsumi, Wataru, additional, Suzuki, Masahiro, additional, Muramatsu, Toshihiro, additional, Yamada, Yoshihiro, additional, Taguchi, Isao, additional, Fukuda, Yoshiaki, additional, Matsui, Akihiro, additional, Kanda, Junji, additional, Hozawa, Koji, additional, Matsumura, Akihiko, additional, Shimizu, Wataru, additional, Yamamoto, Takeshi, additional, Komuro, Issei, additional, Hatano, Masaru, additional, Ikeda, Takanori, additional, Kiuchi, Shunsuke, additional, Chikamori, Taishiro, additional, Takei, Yasuyoshi, additional, Soejima, Kyoko, additional, Minamishima, Toshinori, additional, Tanaka, Hiroyuki, additional, Shimizu, Shigeo, additional, Kasao, Masashi, additional, Kadohira, Tadayuki, additional, Minamino, Tohru, additional, Shimada, Kazunori, additional, Iwata, Hiroshi, additional, Momiyama, Yukihiko, additional, Ashikaga, Takashi, additional, Nozato, Toshihiro, additional, Fujiwara, Yasumasa, additional, Inoue, Kenji, additional, Sasano, Tetsuo, additional, Matsuda, Junji, additional, Ishii, Yasuhiro, additional, Ono, Yuichi, additional, Tanabe, Kengo, additional, Horiuchi, Yu, additional, Shinke, Toshiro, additional, Kodama, Yusuke, additional, Moroi, Masao, additional, Yazaki, Yoshiyuki, additional, Mizumura, Taisuke, additional, Ohta, Hiroshi, additional, Akashi, Yoshihiro, additional, Kotoku, Nozomi, additional, Ikari, Yuji, additional, Maruyama, Mitsunori, additional, Sato, Yasuhiro, additional, Tamura, Koichi, additional, Konishi, Masaaki, additional, Suzuki, Hiroshi, additional, Ebato, Mio, additional, Fukui, Kazuki, additional, Yumoto, Kazuhiko, additional, Iwasawa, Takamasa, additional, Kashimura, Takeshi, additional, Takahashi, Kazuyoshi, additional, Okada, Yoshinobu, additional, Kaku, Bunji, additional, Usuda, Kazuo, additional, Maruyama, Michiro, additional, Kameyama, Tomoki, additional, Higashikata, Toshinori, additional, Hodatsu, Akihiko, additional, Osato, Kazuo, additional, Nagata, Yoji, additional, Maeno, Koji, additional, Satake, Kazuo, additional, Sawanobori, Takao, additional, Watanabe, Noboru, additional, Kuwahara, Koichiro, additional, Motoki, Hirohiko, additional, Kitabayashi, Hiroshi, additional, Otagiri, Kyuhachi, additional, Kono, Tsunesuke, additional, Yamagishi, Daisuke, additional, Yazaki, Yoshikazu, additional, Noda, Toshiyuki, additional, Morishima, Itsuro, additional, Watanabe, Naoki, additional, Tanaka, Shinichiro, additional, Onodera, Tomoya, additional, Nawada, Ryuzo, additional, Watanabe, Akinori, additional, Matsunaga, Masaki, additional, Suwa, Satoru, additional, Sakamoto, Hiroshi, additional, Sakamoto, Hiroki, additional, Aoyama, Takeshi, additional, Kanamori, Norio, additional, Muto, Masahiro, additional, Maekawa, Yuichiro, additional, Ohtani, Hayato, additional, Ozaki, Yukio, additional, Naruse, Kenshin, additional, Takemoto, Kenji, additional, Kamiya, Haruo, additional, Suzuki, Takeshi, additional, Tomita, Yasushi, additional, Suzuki, Susumu, additional, Kametani, Ryosuke, additional, Aoyama, Hidekazu, additional, Osanai, Hiroyuki, additional, Harada, Ken, additional, Kada, Kenji, additional, Saeki, Tomoaki, additional, Kobayashi, Koichi, additional, Ogawa, Yasuhiro, additional, Terasawa, Akihiro, additional, Shinoda, Masanori, additional, Oguri, Mitsutoshi, additional, Shimizu, Kiyokazu, additional, Sawamura, Akinori, additional, Sugiura, Atsushi, additional, Hattori, Kosuke, additional, Mokuno, Shinji, additional, Kondo, Kazuhisa, additional, Dohi, Kaoru, additional, Moriwaki, Keishi, additional, Kasai, Atsunobu, additional, Nakakuki, Tetsuya, additional, Kaitani, Kazuaki, additional, Jinnai, Toshikazu, additional, Yamamoto, Takashi, additional, Kurata, Hiroyuki, additional, Wada, Atsuyuki, additional, Akao, Masaharu, additional, Hamatani, Yasuhiro, additional, Ishibashi, Kazuya, additional, Akakabe, Yoshiki, additional, Asaumi, Yasuhide, additional, Matama, Hideo, additional, Sakata, Yasushi, additional, Kioka, Hidetaka, additional, Takaishi, Hiroshi, additional, Takase, Toru, additional, Matsuda, Mitsuo, additional, Sato, Fumi, additional, Hasegawa, Shinji, additional, Ishigami, Kenichi, additional, Ichikawa, Minoru, additional, Takagi, Takashi, additional, Inoko, Moriaki, additional, Hoshiga, Masaaki, additional, Fujita, Shuichi, additional, Takeda, Yoshihiro, additional, Kawarabayashi, Takahiko, additional, Takaoka, Hideyuki, additional, Nakajima, Kenji, additional, Yuguchi, Tadashi, additional, Kawasaki, Tatsuya, additional, Shinoda, Yukinori, additional, Sato, Yukihito, additional, Ishihara, Masaharu, additional, Matsumoto, Yuki, additional, Kawai, Hiroya, additional, Takaya, Tomofumi, additional, Matsuo, Kouki, additional, Mano, Toshiaki, additional, Hirata, Kenichi, additional, Hisamatsu, Eriko, additional, Inoue, Nobutaka, additional, Tamita, Koichi, additional, Mukohara, Naoki, additional, Shimoyama, Hisashi, additional, Miyajima, Toru, additional, Tamura, Toshihiro, additional, Tamaki, Yodo, additional, Suzuki, Megumi, additional, Yokota, Ryoji, additional, Horii, Manabu, additional, Yamanaka, Kazuo, additional, Kawata, Hiroyuki, additional, Hashimoto, Yukihiro, additional, Nakada, Yasuki, additional, Nakagawa, Hitoshi, additional, Ueda, Tomoya, additional, Nishida, Taku, additional, Seno, Ayako, additional, Watanabe, Makoto, additional, Akasaka, Takashi, additional, Tanimoto, Takashi, additional, Toyofuku, Mamoru, additional, Yamamoto, Kazuhiro, additional, Kinugasa, Yoshiharu, additional, Hirai, Masayuki, additional, Nasu, Hiroshi, additional, Shirota, Kinya, additional, Oda, Tsuyoshi, additional, Oka, Takefumi, additional, Kadota, Kazushige, additional, Ohya, Masanobu, additional, Ito, Hiroshi, additional, Nakamura, Kazufumi, additional, Ogura, Soichiro, additional, Fuke, Soichiro, additional, Uemura, Shiro, additional, Matsubara, Hiromi, additional, Watanabe, Atsuyuki, additional, Morishima, Nobuyuki, additional, Kihara, Yasuki, additional, Hidaka, Takayuki, additional, Ueda, Hironori, additional, Ono, Yujiro, additional, Muraoka, Yuji, additional, Hatanari, Miyo, additional, Miyamoto, Yoshinori, additional, Dote, Keigo, additional, Kato, Masaya, additional, Yano, Masafumi, additional, Mochizuki, Mamoru, additional, Ikeda, Yasuhiro, additional, Fujinaga, Hiroyuki, additional, Hosokawa, Shinobu, additional, Sata, Masataka, additional, Yamaguchi, Koji, additional, Aki, Naoko, additional, Minamino, Tetsuo, additional, Miyake, Yuichi, additional, Takagi, Yuichiro, additional, Doi, Masayuki, additional, Taketani, Yoshio, additional, Okayama, Hideki, additional, Shigematsu, Tatsuya, additional, Higaki, Akinori, additional, Yamaguchi, Osamu, additional, Inaba, Shinji, additional, Ikeda, Shuntaro, additional, Kawai, Kazuya, additional, Kitaoka, Hiroaki, additional, Kubo, Toru, additional, Ando, Kenji, additional, Inui, Kaoru, additional, Fukumoto, Yoshihiro, additional, Hori, Kensuke, additional, Homma, Takehiro, additional, Kawasaki, Tomohiro, additional, Mohri, Masahiro, additional, Fujiwara, Masaki, additional, Tsutsui, Hiroyuki, additional, Ide, Tomomi, additional, Miura, Shin-Ichiro, additional, Kuwano, Takashi, additional, Shimomura, Hideki, additional, Kadokami, Toshiaki, additional, Taba, Masanao, additional, Kondou, Katsuhiro, additional, Kubota, Toru, additional, Nagatomo, Daisuke, additional, Mukai, Yasushi, additional, Matsukawa, Ryuichi, additional, Tashiro, Hideki, additional, Shimomura, Mitsuhiro, additional, Maemura, Koji, additional, Kawano, Hiroaki, additional, Oku, Koji, additional, Yamasa, Toshihiko, additional, Kizaki, Yoshihisa, additional, Sakamoto, Tomohiro, additional, Tamura, Yudai, additional, Ito, Teruhiko, additional, Fujimoto, Kazuteru, additional, Tsujita, Kenichi, additional, Takashio, Seiji, additional, Kurokawa, Hirofumi, additional, Takahashi, Naohiko, additional, Saito, Shotaro, additional, Arikawa, Masaya, additional, Shibata, Yoshisato, additional, Nishihira, Kensaku, additional, Tsuruda, Toshihiro, additional, Sonoda, Masahiro, additional, Atsuchi, Nobuhiko, additional, Ohishi, Mitsuru, additional, Higuchi, Koji, additional, Miyata, Masaaki, additional, Oketani, Naoya, additional, Akimoto, Yoshinori, additional, Asahi, Tomohiro, additional, and Wake, Minoru, additional
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- 2022
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10. Inappropriate subcutaneous implantable cardioverter defibrillator shock due to incomplete sealing of the seal plug: a case report
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Ajimi, Tsuneki, primary, Nozoe, Masatsugu, additional, Suematsu, Nobuhiro, additional, and Kubota, Toru, additional
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- 2022
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11. Calibration of Relative Position between Manipulator and Work by Point-to-Face Touching Method
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Kubota, Toru, Aiyama, Yasumichi, Lee, Sukhan, editor, Suárez, Raúl, editor, and Choi, Byung-Wook, editor
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- 2010
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12. Early use of V2 receptor antagonists is associated with a shorter hospital stay and reduction in in-hospital death in patients with decompensated heart failure
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Matsukawa, Ryuichi, Kubota, Toru, Okabe, Masanori, and Yamamoto, Yusuke
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- 2016
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13. Animal Model of Cardiomyopathy Due to Overexpression of TNF-α
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Kubota, Toru and Matsumori, Akira, editor
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- 2003
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14. Abstract 12372: Sudden Cardiac Death Risk Model Recommended by European Society of Cardiology May Not Be Applicable to Japanese Patients With Hypertrophic Cardiomyopathy
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Yamamoto, Ko, Kubota, Toru, Nozoe, Masatsugu, Suematsu, Nobuhiro, Okabe, Masanori, and Yamamoto, Yusuke
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- 2017
15. Predictive factors for bile leakage after hepatectomy for hepatic tumors: a retrospective multicenter study with 631 cases at Yokohama Clinical Oncology Group (YCOG)
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Nakagawa, Kazuya, Tanaka, Kuniya, Nojiri, Kazunori, Sawada, Yu, Kumamoto, Takafumi, Ueda, Michio, Minami, Yuta, Mochizuki, Yasuhisa, Morioka, Daisuke, Kubota, Toru, Kamiya, Noriyuki, Yoshida, Kenichi, Yonemoto, Naohiro, and Endo, Itaru
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- 2017
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16. Nonylphenol polyethoxylates induce phosphorylation of histone H2AX
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Toyooka, Tatsushi, Kubota, Toru, and Ibuki, Yuko
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- 2012
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17. Ventricular premature complexes successfully ablated from the non-coronary cusp: a case report
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Tanaka, Atsushi, primary, Nozoe, Masatsugu, additional, Tsutsumi, Takaki, additional, and Kubota, Toru, additional
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- 2022
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18. Effects of Patient Background and Treatment Strategy on Clinical Outcomes After Coronary Intervention for Calcified Nodule Lesions
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Nozoe, Masatsugu, primary, Nishioka, Shinki, additional, Oi, Keiji, additional, Suematsu, Nobuhiro, additional, and Kubota, Toru, additional
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- 2021
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19. Optimal Left Ventricle Versus Optimal Afterload
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Sunagawa, Kenji, Hayashida, Kiyoshi, Sugimachi, Masaru, Todaka, Koji, Kubota, Toru, Itaya, Ryoichi, Akiko, Chishaki, Takeshita, Akira, Sasayama, Shigetake, editor, and Suga, Hiroyuki, editor
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- 1991
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20. Antiviral Activity of CD437 Against Mumps Virus
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Kato, Fumihiro, primary, Nakatsu, Yuichiro, additional, Murano, Keiko, additional, Wakata, Aika, additional, Kubota, Toru, additional, Hishiki, Takayuki, additional, Yamaji, Toshiyuki, additional, Kidokoro, Minoru, additional, Katoh, Hiroshi, additional, and Takeda, Makoto, additional
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- 2021
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21. Usefulness of Absorbable Sutures in Preventing Surgical Site Infection in Hepatectomy
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Togo, Shinji, Kubota, Toru, Takahashi, Takuji, Yoshida, Kenichi, Matsuo, Kenichi, Morioka, Daisuke, Tanaka, Kuniya, and Shimada, Hiroshi
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- 2008
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22. Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
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Teerlink, John R., Diaz, Rafael, Felker, G. Michael, McMurray, John J.V., Metra, Marco, Solomon, Scott D., Adams, Kirkwood F., Anand, Inder, Arias‐Mendoza, Alexandra, Biering‐Sørensen, Tor, Böhm, Michael, Bonderman, Diana, Cleland, John G.F., Corbalan, Ramon, Crespo‐Leiro, Maria G., Dahlström, Ulf, Echeverria Correa, Luis E., Fang, James C., Filippatos, Gerasimos, Fonseca, Cândida, Goncalvesova, Eva, Goudev, Assen R., Howlett, Jonathan G., Lanfear, David E., Lund, Mayanna, Macdonald, Peter, Mareev, Vyacheslav, Momomura, Shin‐ichi, O'Meara, Eileen, Parkhomenko, Alexander, Ponikowski, Piotr, Ramires, Felix J. A., Serpytis, Pranas, Sliwa, Karen, Spinar, Jindrich, Suter, Thomas M., Tomcsanyi, Janos, Vandekerckhove, Hans, Vinereanu, Dragos, Voors, Adriaan A., Yilmaz, Mehmet B., Zannad, Faiez, Sharpsten, Lucie, Legg, Jason C., Abbasi, Siddique A., Varin, Claire, Malik, Fady I., Kurtz, Christopher E., Besada, Diego Alejandro, Majul, Claudio Rodolfo, Bruno, Marco Raul Litvak, Sassone, Sonia, Avaca, Horacio Alberto, Rasmussen, Mariela, Aiub, Jorge Roberto, Hominal, Miguel Angel, Perna, Eduardo, Duran, Ruben Omar Garcia, Schiavi, Lilia, Marquez, Lilia Luz Lobo, Vilamajo, Oscar Alberto Gomez, Mackinnon, Ignacio, Fuente, Ricardo Alfonso Leon, Montana, Oscar Romano, Novaretto, Leonardo, Guerrero, Rodolfo Andres Ahuad, Brasca, Daniela Garcia, Prado, Aldo, Garrido, Marcelo Alejandro, Luquez, Hugo, Martinez, Diego Felipe, Nicolosi, Liliana, Parody, Maria Leonor, Zaidman, Cesar, Berra, Fernando Colombo, Ibañez, Julio, Zapata, Gerardo, Caccavo, Alberto, Colque, Roberto, Diez, Mirta, Poy, Carlos, Salomone, Oscar Alejandro, Vogel, Daniel, Bordonava, Anselmo Paulino, Fernandez, Alberto, French, John, Atherton, John, Hamilton, Andrew, Begg, Alistair, Abhayaratna, Walter, Judkins, Christopher, De Pasquale, Carmine, McKenzie, Scott, Amerena, John, Szto, Gregory, Kearney, Leighton, Zimmet, Hendrik, Sverdlov, Aaron, Beltrame, John, Korczyk, Dariusz, Sindone, Andrew, Moertl, Deddo, Huber, Kurt, Huelsmann, Martin, Ablasser, Klemens, Ebner, Christian, Siostrzonek, Peter, Drexel, Heinz, Poelzl, Gerhard, Dujardin, Karl, Dupont, Matthias, Buysschaert, Ian, Lancellotti, Patrizio, Droogne, Walter, Chouchane, Iman, Silveira, Fabio, Rassi, Salvador, Reis, Gilmar, Filho, Pedro Pimentel, Simoes, Marcus Vinicius, Braga, Joao Carlos, Giorgeto, Flavio Eduardo, Ferraz, Almir, Jaeger, Cristiano Pederneiras, Saraiva, Jose Francisco, Tognon, Alexandre, Cardoso, Juliano, Greco, Oswaldo, Paiva, Maria Sanali, Paolino, Bruno, Filho, Otavio Coelho, Maia, Lilia Nigro, Silva, Rodrigo, Canesin, Manoel, Rossi, Paulo Roberto Ferreira, Fortes, Jose Augusto Ribas, Cerci, Rodrigo Julio, Manenti, Euler Roberto Fernandes, Leaes, Paulo Ernesto, Silva Neto, Luis Beck, Souza, Weimar Kunz Barroso, Bacal, Fernando, Chaves, Renato, Ramires, Felix, Vidotti, Maria Helena, Barros e Silva, Pedro Gabriel Melo, Piegas, Leopoldo Soares, Todorov, Georgi, Tzekova, Maria, Goudev, Assen, Mincheva, Valentina, Vasilev, Ivaylo, Tisheva‐ Gospodinova, Snezhanka, Petrov, Ivo, Postadzhiyan, Arman, Velikov, Chavdar, Dimov, Bojidar, Constance, Christian, Phaneuf, Denis‐Carl, Mielniczuk, Lisa, Pandey, A Shekhar, Senaratne, Manohara, Zieroth, Shelley, Savard, Daniel, Stewart, Robert, Huynh, Thao, Giannetti, Nadia, Moe, Gordon, Bourgeois, Ronald, Ezekowitz, Justin, Hartleib, Michael, Sussex, Bruce, Babapulle, Mohan, Chehayeb, Raja, Gaudet, Daniel, McKelvie, Robert, Nguyen, Viviane, Roth, Sherryn, Gupta, Milan, Pesant, Yves, Rupka, Dennis, Bhargava, Rakesh, Costa‐Vitali, Atilio, Proulx, Guy, Vega, Mario, Potthoff, Sergio, Cid, Maria Cristina Schnettler, Sepulveda, Alex Mauricio Villablanca, Zanetti, Fernando Tomas Lanas, Gajardo, Victor Areli Saavedra, Kindel, Carlos Conejeros, Jofre, Christian Paolo Pincetti, Segarra, Jorge Leonardo Cobos, Venegas, Manuel Eduardo Rodriguez, Hidalgo, Mario Yanez, Jalaf, Margarita Gertrudis Vejar, Li, Weimin, Zhang, Jinguo, Fu, Xin, Zhang, Xuelian, Li, Dongye, Wang, Zhifang, Qu, Yanling, Zheng, Zhe, Tang, Huifang, Yang, Ping, Zhang, Yuhui, Zheng, Yang, Mi, Yafei, Huang, He, Bu, Peili, Chen, Guoqin, Chen, Jiyan, Han, Yajun, Li, Zhangquan, Ma, Shumei, Yang, Xuming, Yuan, Zuyi, Dong, Yugang, Li, Zhaoping, Mahemuti, Ailiman, Niu, Wentang, Yang, Zhenyu, Zhang, Yuqing, Sun, Yuemin, Wu, Weiheng, Liu, Feng, Yan, Jing, Li, Yinjun, Wang, Yi, Zhang, Shouyan, Zhou, Changyong, Cui, Hanbin, Li, Jianjun, Li, Tianfa, Han, Qinghua, Wei, Yu, Correa, Luis Eduardo Echeverria, Mendoza, Jose Luis Accini, Jattin, Fernando Manzur, Osorio, Wilder Castaño, Luengas, Carlos Alberto, Arroyo, Julian Alonso Coronel, Corredor, Miguel Alfredo Moncada, Giraldo, Clara Ines Saldarriaga, Lopez, Rodrigo Botero, Salazar, Dora Ines Molina, Triana, Miguel Urina, Lopez, Luis Horacio Atehortua, Rojas, Pastor Olaya, Pelaez, Sebastian Velez, Pareja, Monica Lopez, Bonfanti, Alberto Cadena, Polasek, Rostislav, Monhart, Zdenek, Sochor, Karel, Motovska, Zuzana, Belohlavek, Jan, Busak, Ladislav, Krupicka, Jiri, Tyl, Petr, Jerabek, Ondrej, Podpera, Ivo, Skrobakova, Janka, Peterka, Karel, Spacek, Rudolf, Cech, Vladimir, Kellnerova, Ivana, Nechvatal, Libor, Pozdisek, Zbynek, Houra, Marek, Kryza, Radim, Machova, Vilma, Cepelak, Michal, Stepek, David, Zeman, Kamil, Klimsa, Zdenek, Koleckar, Pavel, Schee, Alexandr, Spinarova, Lenka, Coufal, Zdenek, Jeppesen, Jorgen, Vraa, Soren, Wiggers, Henrik, Nyvad, Ole, Nielsen, Tonny, Kaiser‐Nielsen, Peter, Videbaek, Lars, Galinier, Michel, Lefebvre, Jean‐Marie, Tartiere, Jean‐Michel, De Geeter, Guillaume, Roubille, Francois, Ricci, Jean Etienne, Salvat, Muriel, Gueffet, Jean‐Pierre, Decoulx, Eric, Berdague, Philippe, Jondeau, Guillaume, Ovize, Michel, Groote, Pascal De, Donal, Erwan, Isnard, Richard, Sabatier, Rémi, Trochu, Jean Noel, Damy, Thibaud, Georges, Jean‐Louis, Rosamel, Yann, Picard, François, Aboyans, Victor, Laperche, Thierry, Mitrovic, Veselin, Taggeselle, Jens, Störk, Stefan, Ebelt, Henning, Genth‐Zotz, Sabine, Rassaf, Tienush, Duengen, Hans‐Dirk, Mittag, Marcus, Menck, Niels, Zeymer, Uwe, Haehling, Stephan, Boehm, Michael, Frankenstein, Lutz, Killat, Holger, Bourhaial, Hakima, Beug, Daniel, Horacek, Thomas, Pfister, Roman, Sandri, Marcus, Westenfeld, Ralf, Kadel, Christoph, Karvounis, Haralambos, Patsilinakos, Sotirios, Mantas, Ioannis, Karavidas, Apostolos, Giamouzis, Grigorios, Tsioufis, Konstantinos, Naka, Katerina, Tziakas, Dimitrios, Parissis, John, Styliadis, Ioannis, Barbetseas, Ioannis, Manolis, Athanasios, Kochiadakis, George, Herczeg, Bela, Nagy, Laszlo, Nyolczas, Noemi, Toth, Kalman, Merkely, Bela, Laszlo, Zoltan, Mark, Laszlo, Szakal, Imre, Papp, Andras, Bezzegh, Katalin, Lakatos, Ferenc, Hajko, Erik, Papp, Aniko, Forster, Tamas, Lupkovics, Geza, Mohacsi, Attila, Salamon, Csaba, Aradi, Daniel, Andreka, Peter, Szasz, Gyula, Zilahi, Zsolt, Kazinczy, Rita, Margonato, Alberto, Agostoni, Piergiuseppe, Fucili, Alessandro, Piovaccari, Giancarlo, Senni, Michele, Carluccio, Erberto, Bilato, Claudio, Frigerio, Maria, Indolfi, Ciro, Sinagra, Gianfranco, Brunetti, Natale Daniele, Perna, Gianpiero, Pini, Daniela, Volterrani, Maurizio, Leonardi, Sergio, Mortara, Andrea, Friz, Hernan Emilio Francisco Polo, Rossini, Roberta, Tocchetti, Carlo Gabriele, Vincenzi, Antonella, Cavallini, Claudio, Floresta, Agata Marina, Zaca, Valerio, Giudici, Vittorio, Villani, Giovanni Quinto, Higashino, Yorihiko, Oishi, Shogo, Wada, Atsuyuki, Fukuzawa, Shigeru, Onoue, Kenji, Koike, Akihiro, Koizumi, Tomomi, Masuda, Seigo, Mitsuo, Kazuhisa, Takahashi, Natsuki, Takenaka, Takashi, Tanabe, Jun, Watanabe, Naoki, Yoshida, Takeshi, Amano, Tetsuya, Ishikawa, Masahiro, Kida, Keisuke, Kubota, Toru, Nakamura, Kentaro, Sakamoto, Tomohiro, Shimomura, Mitsuhiro, Yuge, Masaru, Doi, Masayuki, Domae, Hiroshi, Ebato, Mio, Fujii, Kenshi, Fujiwara, Wakaya, Gohara, Seiichiro, Hata, Yoshiki, Kanda, Junji, Kitaoka, Hiroaki, Matsumoto, Takashi, Michishita, Ichiro, Miura, Shinichiro, Miyazaki, Tetsuro, Nakamura, Akihiro, Ogawa, Tomohiro, Okumura, Takahiro, Okumura, Yasuo, Sakai, Tetsuo, Sato, Yukihito, Shimizu, Wataru, Sugino, Hiroshi, Suzuki, Masahiro, Takagi, Atsutoshi, Takaishi, Hiroshi, Tanaka, Takahiro, Terasaki, Toshiro, Tsujimoto, Mitsuru, Ueda, Yasunori, Ujino, Keiji, Usui, Makoto, Yamamoto, Mitsutaka, Yoshikawa, Masaki, Ando, Kenji, Asakura, Masanori, Asano, Hiroshi, Fujii, Shigeru, Hara, Hisao, Inomata, Takayuki, Isshiki, Takaaki, Kadokami, Toshiaki, Kai, Hisashi, Kasai, Toshio, Kawamitsu, Katsunori, Kawasaki, Tomohiro, Koga, Tokushi, Komiyama, Nobuyuki, Maejima, Yasuhiro, Manita, Mamoru, Miyamoto, Nobuhide, Node, Koichi, Numaguchi, Kotaro, Sakata, Yasushi, Serikawa, Takeshi, Takama, Noriaki, Tatebe, Shunsuke, Ueno, Hideki, Hidaka, Takayuki, Hiroi, Shitoshi, Iseki, Harukazu, Ito, Hiroshi, Kajinami, Kouji, Kawakami, Hideo, Momiyama, Yukihiko, Mori, Masuki, Morita, Yukiko, Okishige, Kaoru, Sakagami, Satoru, Takeishi, Yasuchika, Terasawa, Akihiro, Utsu, Noriaki, Badariene, Jolita, Celutkiene, Jelena, Slapikas, Rimvydas, Jarasuniene, Dalia, Castillo, Armando Garcia, De los Rios Ibarra, Manuel Odin, Lopez, Gabriel Arturo Ramos, Llamas, Edmundo Alfredo Bayram, Esperon, Guillermo Antonio Llamas, Vazquez, Eduardo Salcido, Gonzalez, Ricardo Garcia, Leon, Jose Luis Arenas, Gonzalez, Salvador Leon, Mendoza, Maria Alexandra Arias, Rodriguez, Alicia Contreras, Machado, Gustavo Francisco Mendez, Salazar, Melchor Alpizar, Ruiz, Alberto Esteban Bazzoni, Flores, Ana Maria De Leon, Carrasco, Jose Alfredo Pagola, Araiza, Raul Reyes, Römer, Tjeerd, Remmen, Johannes, Van Eck, Jacob, Elvan, Arif, Smilde, Tom, Voors, Adriaan, Wal, Ruud, Schaap, Jeroen, Sluis, Aize, Linssen, Gerardus, Magro, Michael, Willems, Frank, Hal, John, Zwaan, Coenraad, Beelen, Driek, Boswijk, Dirk, Hermans, Walter, Van Kesteren, Henricus, Scott, Russell, Hart, Hamish, Lund, Marianne, Szczasny, Marcin, Blicharski, Tomasz, Kafara, Mariusz, Stankiewicz, Anna, Skonieczny, Grzegorz, Zabowka, Maciej, Kania, Grzegorz, Kopaczewski, Jerzy, Pawlowicz, Lidia, Spyra, Janusz, Wlodarczyk, Aleksander, Sciborski, Ryszard, Balsam, Pawel, Drozdz, Jaroslaw, Sobkowicz, Bozena, Konieczynska, Malgorzata, Lelonek, Malgorzata, Bednarkiewicz, Zbigniew, Trebacz, Jaroslaw, Jankowski, Piotr, Sidor, Mateusz, Berkowski, Piotr, Chmielak, Zbigniew, Lenartowska, Lucyna, Nessler, Jadwiga, Straburzynska‐Migaj, Ewa, Kalarus, Zbigniew, Kowalski, Robert, Kalecinska‐Krystkiewicz, Ewa, Gola, Zbigniew, Pijanowski, Zbigniew, Wozakowska‐Kaplon, Beata, Cymerman, Krzysztof, Rynkiewicz, Andrzej, Miekus, Pawel, Monteiro, Pedro, Sarmento, Pedro Morais, Almeida, Filipa, Duarte, Tatiana, Fonseca, Candida, Oliveira, Luis, Santos, Luis, Brito, Dulce, Stanciulescu, Gabriela, Spiridon, Marilena Renata, Militaru, Constantin, Podoleanu, Cristian Gheorghe, Zdrenghea, Dumitru, Popescu, Mircea Ioachim, Macarie, Cezar‐Eugen, Giuca, Alina, Mitu, Florin, Voicu, Olga‐Cristina, Dorobantu, Maria, Lighezan, Daniel, Stamate, Sorin, Bykov, Alexander, Kobalava, Zhanna, Zrazhevskiy, Konstantin, Semenova, Irina, Vishnevsky, Alexander, Shutemova, Elena, Tereschenko, Sergey, Shvarts, Yury, Barbarash, Olga, Lukyanov, Yury, Voevoda, Mikhail, Dovgolis, Svetlana, Dronov, Dmitry, Goloshchekin, Boris, Sitnikova, Maria, Ezhov, Marat, Tarasov, Nikolay, Kotelnikov, Mikhail, Kostenko, Viktor, Solovev, Oleg, Goncharov, Ivan, Myasnikov, Roman, Rafalskiy, Vladimir, Ryabov, Vyacheslav, Kosmacheva, Elena, Motylev, Igor, Nosov, Vladimir, Osipova, Irina, Salukhov, Vladimir, Belenkiy, Dmitriy, Bolshakova, Olga, Pimenov, Leonid, Shilkina, Nataliya, Kulibaba, Elena, Repin, Alexey, Timofeev, Alexander, Mitrokhin, Vladislav, Sherenkov, Alexander, Arbolishvili, Georgy, Antalik, Lubomir, Dzupina, Andrej, Fulop, Peter, Majercak, Ivan, Gonsorcik, Jozef, Vinanska, Daniela, Lenner, Egon, Lukacova, Jana, Margoczy, Roman, Smik, Rudolf, Stevlik, Jan, Uhliar, Rudolf, Burgess, Lesley, Badat, Aysha, Klug, Eric, Van Zyl, Louis, Abelson, Mark, Moodley, Rajendran, Tsabedze, Nqoba, Fourie, Nyda, Bonet, Luis Almenar, Prado, Jose Maria Arizon, Oliveira Soares, Manue Martinez‐Selles D, Villota, Julio Eduardo Nuñez, Leiro, Maria Generosa Crespo, Juanatey, Jose Ramon Gonzalez, Figal, Domingo Andres Pascual, Palomas, Juan Luis Bonilla, Perez, Sonia Mirabet, Jimenez, Juan Francisco Delgado, Padron, Antonio Lara, Diaz, Victor Alfonso Jimenez, Cubero, Javier Segovia, Paya, Vicente Eduardo Climent, Mayoral, Alejandro Recio, Fuente Galan, Luis, Doblas, Juan Jose Gomez, Freire, Ramon Bover, Peiro, Maria Teresa Blasco, Molina, Beatriz Diaz, Martinez, Laura Jordan, Vilchez, Francisco Gonzalez, Boman, Kurt, Karlstrom, Patric, Berglund, Stefan, Szabo, Barna, Peterson, Magnus, Wodlin, Peter, Lindholm, Carl‐Johan, Moccetti, Tiziano, Mueller, Christian, Suter, Thomas, Hullin, Roger, Meyer, Philippe, Noll, Georg, Yigit, Zerrin, Turgut, Okan Onur, Bekar, Lutfu, Sahin, Tayfun, Koldas, Zehra Lale, Celik, Ahmet, Cavusoglu, Yuksel, Demir, Mesut, Onrat, Ersel, Duzenli, Mehmet, Cosansu, Kahraman, Muderrisoglu, Ibrahim Haldun, Tuncer, Mustafa, Badak, Ozer, Nalbantgil, Sanem, Kirma, Cevat, Okuyan, Ertugrul, Guray, Umit, Prokhorov, Oleksandr, Karpenko, Oleksandr, Vakaliuk, Igor, Yagensky, Andriy, Kracz, Igor, Stanislavchuk, Mykola, Kulynych, Oleksii, Rishko, Mykola, Stets, Roman, Tseluyko, Vira, Mishchenko, Larysa, Rudenko, Leonid, Rudyk, Iurii, Alieksieieva, Liudmyla, Korzh, Oleksii, Mostovoy, Yuriy, Parkhomenko, Oleksandr, Rasputina, Lesya, Voronkov, Leonid, Lymar, Yurii, Vasilyeva, Larysa, Keeling, Philip, Barr, Craig, Wong, Kenneth, Price, Dallas, Skaria, Binoy, Clark, Andrew, Chandrasekaran, Badrinathan, Trevelyan, Jasper, Gordon, Brian, Donnelly, Patrick, Glover, Jason, Ryding, Alisdair, Weir, Robin, Lang, Chim, Roy, Debashis, Adhya, Shaumik, Clifford, Piers, Ludman, Andrew, Kalra, Paul, Lynch, Mary, Mahmood, Shahid, Al Mohammad, Abdallah, Asubiaro, Joshua, Elmahi, Einas, Muthumala, Amal, Taylor, Justin, Gupta, Dinesh, Nadar, Venkatesh, Henderson, David, Zolty, Ronald, Sauer, Andrew, Adams, Kirkwood, Chandra, Lokesh, Jaffrani, Naseem, Grewal, Gurinder, Mancini, Donna, McLean, Dalton, Vasallo, Javier, Gottlieb, Stephen, Joseph, Susan, Barua, Rajat, Gorodeski, Eiran, Mouhaffel, Asad, Chung, Eugene, Desai, Pratik, Portnay, Edward, Rama, Bhola, Shandling, Adrian, Stahl, Llyod, Heilman, Karl, Jacob, Binu, Londono, Juan, Almousalli, Omar, Ashcom, Thomas, Bauerlein, Eugene Joseph, Koo, Charles, McGrew, Frank, Rajagopalan, Navin, Robinson, Shawn, Schultz, David, Starling, Randall, Ambardekar, Amrut, Bhagwat, Ravi, Boehmer, John, Bouza, Manuel, Farris, Neil, Feitell, Scott, Ganji, Jagadeesh, Geltman, Edward, Javier, Julian, Morrow, John Andrew, Pianko, Leonard, Smart, Frank, Adler, Alexander, Brinkley, Douglas, Cardona, Jose, Coletti, Andrew, Harris, John, Hunter, Vernon, Krantz, Mori, Lang, Christopher, Lovell, Charles, Murray, David, Pillutla, Priya, Shah, Amit, Bogaev, Roberta, Dauber, Ira, Franchi, Francesco, Fremont, Richard, Hart, Terence, Hattler, Brack, Janik, Matthew, Khalife, Wissam, Malhotra, Sanjay, Mamdani, Shafiq, Nelson, William, Orgera, Marisa, Ortiz, Aurelio, Rahko, Peter, Rennyson, Stephen, Shin, Jooyoung, Tsao, Lana, Uretsky, Barry, Wahid, Faisal, Wilkett, Matt, Amanullah, Aman, Baker, Mathue, Berk, Martin, Boccalandro, Fernando, Cruz, Kimberly, Doyle, Timothy, Gianfagna, Robert, Jones, Alonzo, King, Anthony, Lepor, Norman, Martinez‐Castrillon, Melvin, Pham, Michael, Radin, Michael, Radojevic, Joseph, Ramanathan, Kodangudi, Schmalfuss, Carsten, Schnitzler, Robert, Shah, Keyur, Takata, Theodore, Bertolet, Barry, Bostick, Brian, Civitello, Andrew, Collins, John, Dib, Nabil, Fang, James, Gilmore, Richard, Gray, Wayne, Grazette, Luanda, Haddad, Tariq, Hearne, Steven, Janmohamed, Munir, Katz, Richard, Kazemi, Navid, Llerena, Sara, Lohr, Nicole, Marzouka, George, Mignone, John, Ooi, Henry, Paszczuk, Anna, Pickett, Christopher, Sampognaro, Gregory, Sawyer, Douglas, Shayani, Steven, Treasure, Charles, Vaz, Garth, Vijay, Nampalli, Williams, Celeste, Yeoman, Gary, Zhang, Lily, Aaronson, Keith, Abo‐Auda, Wael, Alharethi, Rami, Anderson, William, Ariani, Mehrdad, Banerji, Sourin, Baweja, Paramdeep, Carson, Peter, Eberly, Arthur, Elliott, James, Fernando, Ronald, Fisher, Daniel, Forman, Steven, Gabriel, George, Gogia, Harinder, Hametz, Craig, Houston, Brian, Ibrahim, Hassan, Jadbabaie, Farid, Kassiotis, Christos, Krishnamoorthy, Arun, Kwan, Michael, Lupovitch, Steven, Macias, Leonardo, Malik, Adnan, Martinez, Luis, Miyamoto, Michael, Mody, Freny, Patel, Devesh, Peart, Brenda, Pisani, Barbara, Ramos, Mark, Rivero, Mariel, Shah, Anil, Sharma, Mukesh, Sichrovsky, Tina, Simon, Marc, Singh, Deovrat, Tallet, Julio, Vaccari, Christopher, Villoch, Mario, Wheeler, Matthew, Yousuf, Kabir, Abadier, Rafik, Abdullah, Shuaib, Arora, Raveen, Aslam, Shamaila, Buynak, Robert, Chang, David, Contreras, Johanna, Halpern, Stephen, Handel, Franklin, Heitner, John, Herzog, William, Jackson, Bruce, Kao, John, Kondo, Nicholas, Koren, Michael, LeWinter, Martin, Martindale, Jeffrey, Martinez‐Arraras, Joaquin, Olsen, Stephanie, Piatek, Marek, Ranadive, Nandkishore, Randall, William, Rao, Sunder, Rawitscher, David, Rider, James, Sokos, George, Strader, J Russell, Sulemanjee, Nasir, Tahirkheli, Naeem, Trichon, Benjamin, Vanhecke, Thomas, Whellan, David, Abuannadi, Mohammad, Aggarwala, Gaurav, Ahmad, Saad, Artis, Andre, Cheirif, Jorge, Cotarlan, Vladimir, Cox, Jeremy, Eaton, Charles, Florea, Viorel, Frank, Theodore, Friedman, Keith, Ganeshram, Vedampattu, Gass, Alan, Gemignani, Anthony, Hasni, Syed, Hedgepeth, Chester, Itchhaporia, Dipti, Kaluski, Edo, Karim, Amin, Kono, Alan, Lader, Ellis, Lakshminarayanan, Batlagundu, Lewis, Neil, Malhotra, Vinay, Mayer, Nolan, Mohapatra, Robert, Nair, Nandini, O'Brien, Terrence, Pauwaa, Sunil, Rowan, Christopher, Saxena, Sanjeev, Seto, Arnold, Shah, Nishant, Singh, Pradeep, Skopicki, Hal, Stoddard, Marcus, and Sweitzer, Nancy
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R1 - Abstract
Aims:\ud The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.\ud \ud Methods and Results:\ud Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure
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- 2020
23. Tumor necrosis factor-[alpha] is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction
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Monden, Yoshiya, Kubota, Toru, Inoue, Takahiro, Tsutsumi, Takaki, Kawano, Shunichi, Ide, Tomomi, Tsutsui, Hiroyuki, and Sunagawa, Kenji
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Tumor necrosis factor -- Research ,Heart muscle -- Research ,Heart attack -- Research ,Heart failure -- Research ,Cytokines -- Research ,Heart cells -- Research ,Cellular control mechanisms -- Research ,Cardiovascular research ,Biological sciences - Abstract
Tumor necrosis factor (TNF)-[alpha] induced in damaged myocardium has been considered to be cardiotoxic. TNF-[alpha] initiates its biological effects by binding two distinct receptors: R1 (p55) and R2 (p75). Although TNF-[alpha] has been shown to be cardiotoxic via R1-mediated pathways, little is known about the roles of R2-mediated pathways in myocardial infarction (MI). We created MI in R1 knockout (R1KO), R2KO, and wild-type (WT) mice by ligating the left coronary artery. Functional, histological, and biochemical analyses were performed 4 wk after ligation. Although infarct size was not different among WT, R1KO, and R2KO mice, post-MI survival was significantly improved in R1KO but not R2KO mice. R1KO significantly ameliorated contractile dysfunction after MI, whereas R2KO significantly exaggerated ventricular dilatation and dysfunction. Myocyte hypertrophy and interstitial fibrosis in noninfarct myocardium was exacerbated in R2KO but not in R1KO mice. Expression of R1, which was not affected by MI and was nullified in R1KO mice, was significantly upregulated in R2KO mice. In contrast, expression of R2, which was significantly upregulated by MI and was nullified in R2KO mice, was unaffected in R1KO mice. Meanwhile, TNF-[alpha] expression, which was significantly upregulated in noninfarct myocardium after MI, was not affected by R1KO or R2KO. However, transcript levels of IL-6, IL-1 [beta], transforming growth factor-[beta], and monocyte chemotactic protein-l, which were significantly upregulated after MI, were significantly downregulated in R1KO mice. In contrast, transcript levels of IL-6 and IL-1 [beta] were significantly further upregulated in R2KO mice. TNF-[alpha] is toxic via R1 and protective via R2 in a murine model of MI. Selective blockade of RI may be a candidate therapeutic intervention for MI. cytokines; heart failure; remodeling; interstitial fibrosis doi:10.1152/ajpregu.00166.2006
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- 2007
24. A long-term survivor keeping in a complete response without treatment after pemetrexed maintenance therapy for advanced non-squamous non-small cell lung cancer
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Furugen, Makoto, Shibahara, Daisuke, Kiyuna, Tomo, Kami, Wakaki, Miyagi, Kazuya, Haranaga, Shusaku, Kubota, Toru, Matsumoto, Hirofumi, Yoshimi, Naoki, Fujita, Jiro, Furugen, Makoto, Shibahara, Daisuke, Kiyuna, Tomo, Kami, Wakaki, Miyagi, Kazuya, Haranaga, Shusaku, Kubota, Toru, Matsumoto, Hirofumi, Yoshimi, Naoki, and Fujita, Jiro
- Abstract
Pemetrexed has significant efficacy for some non-squamous non-small cell lung cancer cases, as demonstrated in the current case. For those patients, pemetrexed administration should be carefully considered.
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- 2020
25. Pharmacologic preconditioning effects: Prostaglandin E1 induces heat-shock proteins immediately after ischemia/reperfusion of the mouse liver
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Matsuo, Ken-ichi, Togo, Shinji, Sekido, Hitoshi, Morita, Tomoyuki, Kamiyama, Masako, Morioka, Daisuke, Kubota, Toru, Miura, Yasuhiko, Tanaka, Kuniya, Ishikawa, Takashi, Ichikawa, Yasushi, Endo, Itaru, Goto, Hitoshi, Nitanda, Hiroyuki, Okazaki, Yasushi, Hayashizaki, Yoshihide, and Shimada, Hiroshi
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- 2005
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26. Contrast-enhanced sonography of pancreatic carcinoma: correlations with pathological findings
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Numata, Kazushi, Ozawa, Yutaka, Kobayashi, Noritoshi, Kubota, Toru, Shimada, Hiroshi, Nozawa, Akinori, Nakatani, Yukio, Sugimori, Kazuya, Matsuo, Kenichi, Imada, Toshio, and Tanaka, Katsuaki
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- 2005
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27. the role of splenomesenteric vein anastomosis after division of the splenic vein in pancreatoduodenectomy
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Misuta, Koichiro, Shimada, Hiroshi, Miura, Yasuhiko, Kunihiro, Osamu, Kubota, Toru, Endo, Itaru, Sekido, Hitoshi, and Togo, Shinji
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- 2005
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28. Efficacy of Hepatic Resection for Hepatocellular Carcinomas Larger than 10 cm
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Nagano, Yasuhiko, Tanaka, Kuniya, Togo, Shinji, Matsuo, Kenichi, Kunisaki, Chikara, Sugita, Mitsutaka, Morioka, Daisuke, Miura, Yasuhiko, Kubota, Toru, Endo, Itaru, Sekido, Hitoshi, and Shimada, Hiroshi
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- 2005
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29. Blockade of NF-[kappa]B improves cardiac function and survival after myocardial infarction
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Kawano, Shunichi, Kubota, Toru, Monden, Yoshiya, Tsutsumi, Takaki, Inoue, Takahiro, Kawamura, Natsumi, Tsutsui, Hiroyuki, and Sunagawa, Kenji
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Cardiac resuscitation -- Research ,Genetically modified mice -- Research ,Genetically modified mice -- Physiological aspects ,Heart attack -- Research ,Inflammation -- Research ,Biological sciences - Abstract
Blockade of NF-[kappa]B is a key transcription factor that regulates inflammatory processes. In the present study, we tested the hypothesis that blockade of NF-[kappa]B ameliorates cardiac remodeling and failure after myocardial infarction (MI). Knockout mice with targeted disruption of the p50 subunit of NF-[kappa]B (KO) were used to block the activation of NF-[kappa]B. MI was induced by ligation of the left coronary artery in male KO and age-matched wild-type (WT) mice. NF-[kappa]B was activated in noninfarct as well as infarct myocardium in WT + MI mice, while the activity was completely abolished in KO mice. Blockade of NF-[kappa]B significantly reduced early ventricular rupture after MI and improved survival by ameliorating congestive heart failure. Echocardiographic and pressure measurements revealed that left ventricular fractional shortening and maximum rate of rise of left ventricular pressure were significantly increased and end-diastolic pressure was significantly decreased in KO + MI mice compared with WT + MI mice. Histological analysis demonstrated significant suppression of myocyte hypertrophy as well as interstitial fibrosis in the noninfarct myocardium of KO + MI mice. Blockade of NF-[kappa]B did not ameliorate expression of proinflammatory cytokines in infarct or noninfarct myocardium. In contrast, phosphorylation of c-Jun N[H.sub.2]-terminal kinase was almost completely abolished in KO + MI mice. The present study demonstrates that targeted disruption of the p50 subunit of NF-[kappa]B reduces ventricular rupture as well as improves cardiac function and survival after MI. Blockade of NF-[kappa]B might be a new therapeutic strategy to attenuate cardiac remodeling and failure after MI. cardiac remodeling; inflammation; mitogen-activated protein kinases doi:10.1152/ajpheart.01175.2005
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- 2006
30. Cardioprotection afforded by NF-KB ablation is associated with activation of Akt in mice overexpressing TNF-[alpha]
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Higuchi, Yoshihiro, Chan, Tung O., Brown, Maria A., Zhang, Jin, DeGeroge, Brent R., Jr., Funakoshi, Hajime, Gibson, Gregory, McTiernan, Charles F., Kubota, Toru, Jones, W. Keith, and Feldman, Arthur M.
- Subjects
Cardiomyopathy -- Care and treatment ,Heart diseases -- Care and treatment ,Tumor necrosis factor -- Research ,Protein kinases -- Research ,Biological sciences - Abstract
When selectively overexpressed in mouse heart, TNF-[alpha] effects the development of a cardiomyopathy that closely mimics that seen in human failing hearts. It has been suggested that two intracellular signaling pathways, the Akt protein kinase and the NF-[kappa]B transcription factor, mediated TNF-[alpha] signaling. The present experiments assessed the effects of TNF-[alpha] overexpression on these two target proteins in vivo. We measured cardiac Akt kinase phosphorylation and NF-[kappa]B activity in mice overexpressing TNF-[alpha] (TNF1.6). Both basal and insulin-stimulated Akt phosphorylation were reduced by almost 70% by TNF-[alpha] overexpression. By contrast, NF-[kappa]B was robustly activated. These effects were absent when TNF-[alpha] receptor 1 (TNFR1) was selectively ablated. Cardiomyocyte-specific overexpression of the dominant-negative inhibitory [kappa]B protein transgene and subsequent inhibition of NF-[kappa]B activity attenuated the effects of TNF-[alpha] on Akt phosphorylation. NF-[kappa]B inhibition also significantly improved fractional shortening and diminished ventricular hypertrophy and survival without affecting infiltrative inflammation or cytokine expression. Thus, while overexpression of TNF-[alpha] effected a marked Akt inhibition and NF-[kappa]B activation in mouse hearts, inhibition of NF-[kappa]B offered salutary benefits mediated at least in part through activation of Akt. tumor necrosis factor-[alpha]; insulin signaling; TNF-[alpha] receptor; protein kinase B; dominant-negative inhibitory [kappa]B protein transgene
- Published
- 2006
31. Successful Catheter Ablation for Multiple Atrial Arrhythmias in a Patient with Situs Inversus Totalis
- Author
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Tsujioka, Satoshi, primary, Nozoe, Masatsugu, additional, Kawano, Yuki, additional, Suematsu, Nobuhiro, additional, and Kubota, Toru, additional
- Published
- 2021
- Full Text
- View/download PDF
32. EFFECT OF WAVE INCIDENT ANGLE ON HYDRAULIC PERFORMANCE OF SLIT CAISSON
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KUBOTA, Toru, primary, HASEGAWA, Iwao, additional, TAKAHASHI, Yasuhiro, additional, NAKAGAWA, Hiroshi, additional, KOBAYASHI, Shigenori, additional, WATANABE, Masaharu, additional, and KESHO, Jun-ichiro, additional
- Published
- 2021
- Full Text
- View/download PDF
33. Incidental Gallbladder Cancer on Cholecystectomy: Strategy for Re-resection of Presumed Benign Diseases from a Retrospective Multicenter Study by the Yokohama Clinical Oncology Group
- Author
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MATSUYAMA, RYUSEI, primary, MATSUO, KENICHI, additional, MORI, RYUTARO, additional, SUGITA, MITSUTAKA, additional, YAMAGUCHI, NAOTAKA, additional, KUBOTA, TORU, additional, KAMEDA, KUNIO, additional, MOCHIZUKI, YASUHISA, additional, TAKAGAWA, RYO, additional, KADOKURA, TOSHIAKI, additional, MATSUDA, GORO, additional, KAMIYA, NORIYUKI, additional, and ENDO, ITARU, additional
- Published
- 2021
- Full Text
- View/download PDF
34. Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy
- Author
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Matsusaka, Hidenori, Ikeuchi, Masaki, Matsushima, Shouji, Ide, Tomomi, Kubota, Toru, Feldman, Arthur M., Takeshita, Akira, Sunagawa, Kenji, and Tsutsui, Hiroyuki
- Subjects
Tumor necrosis factor -- Research ,Heart failure -- Causes of ,Biological sciences - Abstract
Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a pathophysiological role in the development and progression of heart failure. Matrix metalloproteinase (MMP)-2 is involved in extracellular matrix remodeling. Recent evidence suggests a protective role for this protease against tissue inflammation. Although MMP-2 is upregulated in the failing heart, little is known about its pathophysiological role. We thus hypothesized that ablation of the MMP-2 gene could affect cardiac remodeling and failure in TNF-[alpha]-induced cardiomyopathy. We crossed transgenic mice with cardiac-specific overexpression of TNF-[alpha] (TG) with MMP-2 knockout (KO) mice. Four groups of male and female mice were studied: wild-type (WT) with wild MMP-2 (WT/MM[P.sup.+/+]), WT with MMP-2 KO (WT/MM[P.sup.-/-]), TNF-[alpha] TG with wild MMP-2 (TG/MMP+/+), and TG with MMP-2 KO (TG/MM[P.sup.-/-]). The upregulation of MMP-2 zymographic activity in TG/MM[P.sup.+/+] mice was completely abolished in TG/MM[P.sup.-/-] mice, and other MMPs and tissue inhibitors of metalloproteinase were comparable between groups. Survival was shorter for male TG/ MM[P.sup.-/-] than TG/MM[P.sup.+/+] mice. Female TG/MM[P.sup.-/-] mice were more severely affected than TG/MM[P.sup.+/+] mice with diminished cardiac function. Myocardial TNF-[alpha] and other proinflammatory cytokines were increased in TG/MM[P.sup.+/+] mice, and this increase was similarly observed in TG/MMP[P.sup.-/-] mice. The extent of myocardial infiltrating cells including macrophages was greater in TG/MMP[P.sup.-/-] than in TG/MM[P.sup.+/+] mice. Selective ablation of the MMP-2 gene reduces survival and exacerbates cardiac failure in association with the increased level of myocardial inflammation. MMP-2 may play a cardioprotective role in the pathogenesis of cytokine-induced cardiomyopathy. metalloproteinases; heart failure; tumor necrosis factor
- Published
- 2005
35. A long‐term survivor keeping in a complete response without treatment after pemetrexed maintenance therapy for advanced non‐squamous non‐small cell lung cancer
- Author
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Furugen, Makoto, primary, Shibahara, Daisuke, additional, Kiyuna, Tomo, additional, Kami, Wakaki, additional, Miyagi, Kazuya, additional, Haranaga, Shusaku, additional, Kubota, Toru, additional, Matsumoto, Hirofumi, additional, Yoshimi, Naoki, additional, and Fujita, Jiro, additional
- Published
- 2020
- Full Text
- View/download PDF
36. Isolation of Legionella anisa from multiple sites of a hospital water system: the eradication of Legionella contamination
- Author
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Yamamoto, Natsuo, Kubota, Toru, Tateyama, Masao, Koide, Michio, Nakasone, Chikara, Tohyama, Masato, Shinzato, Takashi, Higa, Futoshi, Kusano, Nobuchika, Kawakami, Kazuyoshi, and Saito, Atsushi
- Published
- 2003
- Full Text
- View/download PDF
37. UVB irradiation changes genotoxic potential of nonylphenolpolyethoxylates— remarkable generation of γ-H2AX with degradation of chemical structure
- Author
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Toyooka, Tatsushi, Kubota, Toru, and Ibuki, Yuko
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- 2013
- Full Text
- View/download PDF
38. Mechanism of postoperative liver failure after excessive hepatectomy investigated using a cDNA microarray
- Author
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Morita, Tomoyuki, Togo, Shinji, Kubota, Toru, Kamimukai, Nobuyuki, Nishizuka, Itaru, Kobayashi, Takatoshi, Ichikawa, Yasushi, Ishikawa, Takashi, Takahashi, Shinji, Matsuo, Kenichi, Tomaru, Yasuhiro, Okazaki, Yasushi, Hayashizaki, Yoshihide, and Shimada, Hiroshi
- Published
- 2002
- Full Text
- View/download PDF
39. Severe fatty change of the graft liver caused by a portosystemic shunt of mesenteric varices
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Sekido, Hitoshi, Matsuo, Ken-ichi, Takeda, Kazuhisa, Morioka, Daisuke, Kubota, Toru, Tanaka, Kuniya, Endo, Itaru, Togo, Shinji, Tanaka, Koichi, and Shimada, Hiroshi
- Published
- 2002
- Full Text
- View/download PDF
40. Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction
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Hayashidani, Shunji, Tsutsui, Hiroyuki, Ikeuchi, Masaki, Shiomi, Tetsuya, Matsusaka, Hidenori, Kubota, Toru, Imanaka-Yoshida, Kyoko, Itoh, Takeshi, and Takeshita, Akira
- Subjects
Heart failure -- Physiological aspects ,Coronary arteries -- Physiological aspects ,Biological sciences - Abstract
Matrix metalloproteinase-2 (MMP-2) is prominently overexpressed both after myocardial infarction (MI) and in heart failure. However, its pathophysiological significance in these conditions is still unclear. We thus examined the effects of targeted deletion of MMP-2 on post-MI left ventricular (LV) remodeling and failure. Anterior MI was produced in 10- to 12-wk-old male MMP-2 knock-out (KO) and sibling wild-type (WT) mice by ligating the left coronary artery. By day 28, MI resulted in a significant increase in mortality in association with LV cavity dilatation and dysfunction. The MMP-2 KO mice had a significantly better survival rate than WT mice (56% vs. 85%, P < 0.05), despite a comparable infarct size (50 [+ or -] 3% vs. 51 [+ or -] 3%, P = not significant), heart rate, and arterial blood pressure. The KO mice had a significantly lower incidence of LV rupture (10% vs. 39%, P < 0.05), which occurred within 7 days of MI. The KO mice exerted less LV cavity dilatation and improved fractional shortening after MI by echocardiography. The LV zymographic MMP-2 level significantly increased in WT mice after coronary artery ligation; however, this was completely prevented in KO mice. In contrast, the increase in the LV zymographic MMP-9 level after MI was similar between KO and WT mice. MMP-2 activation is therefore considered to contribute to an early cardiac rupture as well as late LV remodeling after MI. The inhibition of MMP-2 activation may therefore be a potentially useful therapeutic strategy to manage post-MI hearts. matrix metalloproteinase; cardiac rupture; heart failure; myocyte; extracellular matrix; mouse
- Published
- 2003
41. Overexpression of tumor necrosis factor-[alpha] increases production of hydroxyl radical in murine myocardium
- Author
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Machida, Yoji, Kubota, Toru, Kawamura, Natsumi, Funakoshi, Hajime, Ide, Tomomi, Utsumi, Hideo, Li, Yun You, Feldman, Arthur M., Tsutsui, Hiroyuki, Shimokawa, Hiroaki, and Takeshita, Akira
- Subjects
Heart muscle -- Research ,Physiology -- Research ,Heart failure -- Research ,Tumor necrosis factor -- Research ,Biological sciences - Abstract
Transgenic (TG) mice with cardiac-specific overexpression of tumor necrosis factor-[alpha] develop congestive heart failure with myocardial inflammation. The purpose of this study was to investigate the effects of tumor necrosis factor-[alpha] on reactive oxygen species (ROS) in this mouse model of cardiomyopathy. Myocardial production of hydroxyl radical detected by electron spin resonance spectroscopy was significantly increased in TG. Myocardial expression of Mn-SOD was significantly decreased in TG, whereas that of Cu,Zn-SOD was unaltered. Myocardial expression of catalase was unchanged, whereas that of glutathione peroxidase was significantly increased, in TG. Histological analysis revealed that macrophages and CD4-positive lymphocytes were increased in TG myocardium. To investigate whether these infiltrating inflammatory cells were the source of ROS, we treated TG mice with cyclophosphamide for 7 days. Although cyclophosphamide significantly suppressed the infiltration of inflammatory cells, it did not diminish the production of hydroxyl radical in TG myocardium. Damaged myocytes, but not infiltrating inflammatory cells, may be the source of ROS in TG. cytokine; heart failure; reactive oxygen species
- Published
- 2003
42. Calcium-dependent arrhythmias in transgenic mice with heart failure
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London, Barry, Baker, Linda C., Lee, Joon S., Shusterman, Vladimir, Choi, Bum-Rak, Kubota, Toru, McTiernan, Charles F., Feldman, Arthur M., and Salama, Guy
- Subjects
Physiology -- Research ,Heart failure -- Research ,Arrhythmia -- Research ,Biological sciences - Abstract
Transgenic mice overexpressing the inflammatory cytokine tumor necrosis factor (TNF)-[alpha] (TNF-[alpha] mice) in the heart develop a progressive heart failure syndrome characterized by biventricular dilatation, decreased ejection fraction, atrial and ventricular arrhythmias on ambulatory telemetry monitoring, and decreased survival compared with nontransgenic littermates. Programmed stimulation in vitro with single extra beats elicits reentrant ventricular arrhythmias in TNF-[alpha] (n = 12 of 13 hearts) but not in control hearts. We performed optical mapping of voltage and [Ca.sup.2+] in isolated perfused ventricles of TNF-[alpha] mice to study the mechanisms that lead to the initiation and maintenance of the arrhythmias. When compared with controls, hearts from TNF-[alpha] mice have prolonged of action potential durations (action potential duration at 90% repolarization: 23 [+ or -] 2 ms, n = 7, vs. 18 [+ or -] 1 ms, n = 5; P < 0.05), no increased dispersion of refractoriness between apex and base, elevated diastolic and depressed systolic [[Ca.sup.2+]], and prolonged [Ca.sup.2+] transients (72 [+ or -] 6 ms, n = 10, vs. 54 [+ or -] 5 ms, n = 8; P < 0.01). Premature beats have diminished action potential amplitudes and conduct in a slow, heterogeneous manner. Lowering extracellular [[Ca.sup.2+]] normalizes conduction and prevents inducible arrhythmias. Thus both action potential prolongation and abnormal [Ca.sup.2+] handling may contribute to the initiation of reentrant arrhythmias in this heart failure model by mechanisms distinct from enhanced dispersion of refractoriness or triggered activity. optical mapping; genetically engineered mice
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- 2003
43. Diagnosis of advanced hepatocellular carcinoma using contrast-enhanced harmonic gray-scale imaging with enhancement agents (Levovist): Correlation with helical CT and US angiography
- Author
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Hara, Koji, Numata, Kazushi, Tanaka, Katsuaki, Saito, Satoru, Morimoto, Manabu, Ikeda, Masanori, Iwase, Shigeru, Matsumoto, Shuhei, Yonezawa, Hiromi, Kubota, Toru, and Sekihara, Hisahiko
- Published
- 2001
- Full Text
- View/download PDF
44. Long-term survival of rat cardiac allografts by intrathymic plus portal venous injections of donor bone marrow cells and short-term tacrolimus immunosuppression
- Author
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Fukada, Johji, Kurimoto, Yoshihiko, Ruiz, Phillip, Aitouche, Abdelouahab, Zeevi, Adriana, Li, S., Kubota, Toru, and Pham, S. M.
- Published
- 2001
- Full Text
- View/download PDF
45. Adjuvant therapies using biliary stenting for malignant biliary obstruction
- Author
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Miura, Yasuhiko, Endo, Itaru, Togo, Shinji, Sekido, Hitoshi, Misuta, Koichiro, Fujii, Yoshiro, Kubota, Toru, Tanaka, Kuniya, Nagahori, Kaoru, and Shimada, Hiroshi
- Published
- 2001
- Full Text
- View/download PDF
46. A Successful Case of Switching Treatment from Ketamine to Methadone for Complex Neuropathic Pain.
- Author
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Murakami, Satoshi, Asada, Takaaki, Kubota, Toru, Kawakami, Hiroyuki, Kokubun, Hideya, and Uezono, Yasuhito
- Subjects
METHADONE treatment programs ,THERAPEUTICS ,CANCER pain ,PAIN measurement ,NEURALGIA ,RECTUM tumors ,ACTIVITIES of daily living ,KETAMINE ,PAIN management ,DISEASE complications - Abstract
Background: Methadone is frequently used for the management of complex pain at the end of life by palliative care specialists. It is also used in low doses as an add-on therapy to chronic opioid treatment of cancer-related pain, usually with good effect, and without any reported severe adverse effects. However, there are few reports of switching from ketamine to methadone. Case: We report a case of a patient with rectal cancer and intractable pain. Switching from ketamine to methadone to maintain analgesia was successfully carried out without impacting activities of daily living. Established measurement tools, such as numerical rating scale, Douleur Neuropathique, Functional Independence Measure, and Barthel Index, were used. Conclusion: Switching from ketamine to methadone may be beneficial in relieving refractory cancer-related neuropathic pain without decreasing functioning. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
47. Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-[alpha]
- Author
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Funakoshi, Hajime, Kubota, Toru, Machida, Yoji, Kawamura, Natsumi, Feldman, Arthur M., Tsutsui, Hiroyuki, Shimokawa, Hiroaki, and Takeshita, Akira
- Subjects
Genetically modified mice -- Physiological aspects ,Heart failure -- Physiological aspects ,Cytokines -- Physiological aspects ,Tumor necrosis factor -- Physiological aspects ,Nitric oxide -- Physiological aspects ,Biological sciences - Abstract
Transgenic (TG) mice with cardiac-specific overexpression of tumor necrosis factor (TNF)-[alpha] develop dilated cardiomyopathy with myocardial inflammation. The purpose of this study was to investigate the role of nitric oxide (NO) in this mouse model of cardiomyopathy. Female TG and wild-type mice at the age of 10 wk were studied. The expression and activity of inducible NO synthase (iNOS) were significantly increased in the TG myocardium, whereas those of endothelial NOS were not altered. The majority of the iNOS protein was isolated in the interstitial cells. The selective iNOS inhibitor (1S,5S,6R,7R)-7-chloro-3-imino-5-methyl-2-azabicyclo [4.1.0]heptane hydrochloride (ONO-1714) was used to examine the effects of iNOS induction on myocardial contractility. Echocardiography and left ventricular pressure measurements were performed. Both fractional shortening and the maximum rate of rise of left ventricular pressure were significantly suppressed in TG mice. Although ONO-1714 did not change hemodynamic parameters or contractility at baseline, it significantly improved [beta]-adrenergic inotropic responsiveness in TG mice. These results indicate that induction of iNOS may play an important role in the pathogenesis of cardiac dysfunction in this mouse model of cytokine-induced cardiomyopathy. cytokine; heart failure; transgenic mice
- Published
- 2002
48. Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice
- Author
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Shusterman, Vladimir, Usiene, Irmute, Harrigal, Chivonne, Lee, Joon Sup, Kubota, Toru, Feldman, Arthur M., and London, Barry
- Subjects
Physiology -- Research ,Electrophysiology -- Research ,Heart beat -- Research ,Biological sciences - Abstract
Transgenic mice are widely used to study cardiac function, but strain-dependent differences in autonomic nervous system activity (ANSA) have not been explored. We compared 1) short-term pharmacological responses of cardiac rhythm in FVB vs. C57Black6/SV129 wild-type mice and 2) long-term physiological dynamics of cardiac rhythm and survival in tumor necrosis factor (TNF)-[alpha] transgenic mice with heart failure (TNF-[alpha] mice) on defined backgrounds. Ambulatory telemetry electrocardiographic recordings and response to saline, adrenergic, and cholinergic agents were examined in FVB and C57Black6/SV129 mice. In FVB mice, baseline heart rate (HR) was higher and did not change after injection of isoproterenol or atropine but decreased with propranolol. In C57Black6/SV129 mice, HR did not change with propranolol but increased with isoproterenol or atropine. Mean HR, but not indexes of HR variability, was an excellent predictor of response to autonomic agents. The proportion of surviving animals was higher in TNF-[alpha] mice on an FVB background than on a mixed FVB/C57Black6 background. The homeostatic states of ANSA are strain specific, which can explain the interstrain differences in mean HR, pharmacological responses, and survival of animals with congestive heart failure. Strain-specific differences should be considered in selecting the strains of mice used for transgenic and gene targeting experiments. electrophysiology; transgenic models; heart rate
- Published
- 2002
49. Clinicopathologic findings of recurrent primary sclerosing cholangitis after orthotopic liver transplantation
- Author
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Kubota, Toru, Thomson, Andrew, Clouston, Andrew D., Nakazawa, Yuichi, Steadman, Charles, Kerlin, Paul, Shimada, Hiroshi, Balderson, Glenda A., Lynch, Stephen V., and Strong, Russell W.
- Published
- 1999
- Full Text
- View/download PDF
50. Liver transplantation for primary sclerosing cholangitis
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Sekido, Hitoshi, Takeda, Kazuhisa, Morioka, Daisuke, Kubota, Toru, Tanaka, Kuniya, Endo, Itaru, Nagahori, Kaoru, Togo, Shinji, and Shimada, Hiroshi
- Published
- 1999
- Full Text
- View/download PDF
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