4,374 results on '"Kubota, M"'
Search Results
2. Personality Traits Associated with Treatment Choice with an Explicit Statistical Prediction After an Explanation in a Negative Context: A Study in Patients with Glaucoma
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Kodaka F, Noro T, Kishimoto N, Kurosawa M, Itoh Y, Ogawa S, Watanabe T, Kubota M, Hori K, Shigeta M, and Nakano T
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conscientiousness ,neuroticism ,glaucoma ,big five personality traits ,Ophthalmology ,RE1-994 - Abstract
Fumitoshi Kodaka,1,* Takahiko Noro,2,* Nanami Kishimoto,2 Mei Kurosawa,2 Yoshinori Itoh,2 Shumpei Ogawa,2 Tomoyuki Watanabe,2 Masaomi Kubota,2 Kiyotaka Hori,3 Masahiro Shigeta,1 Tadashi Nakano2 1Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; 3Japan Medical Affairs, Santen Pharmaceutical Co., Ltd, Tokyo, Japan*These authors contributed equally to this workCorrespondence: Tadashi Nakano, Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 103-0003, Japan, Tel +81 3-3433-1111, Fax +81 3-3437-2665, Email tnakano@jikei.ac.jpPurpose: Over 50% of patients with early-stage glaucoma discontinue topical therapy within the first 6 months of treatment initiation. This risk of discontinuation could be reduced by how the ophthalmologist explains the treatment plan. Ophthalmologists can explain the treatment plan to patients in either positive or negative contexts. Although explanations in a negative context can be selected depending on the medical situation, identification of patients who will choose the treatment with explicit statistical prediction after an explanation in a negative context is important; personality traits are related to these emotional decisions. Therefore, in the present study, we examined the personality traits associated with choice of treatment with explicit statistical prediction after an explanation in a negative context.Patients and Methods: A total of 147 patients with glaucoma were recruited for this study. The questionnaire booklets used contained positively framed or negatively framed versions of an “Asian disease problem” to enable examination of the influence of the way in which a problem is framed (framing effect) on the participants’ decision-making. The Japanese version of the Ten-Item Personality Inventory was used to estimate the personality traits of the participants.Results: Low conscientiousness was identified as the only variable that was strongly predictive of the choice of treatment with explicit statistical prediction (β = − 0.44, z = 2.19, p = 0.03). In addition, while the association was not statistically significant, low neuroticism was found to be weakly predictive of the choice of uncertain treatment (β = − 0.37, z = 1.73, p = 0.08).Conclusion: In conclusion, we showed that low levels of conscientiousness predict the choice of treatment with explicit statistical prediction (ie, topical treatment) for glaucoma after an explanation in a negative context.Keywords: conscientiousness, neuroticism, glaucoma, big five personality traits
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- 2023
3. Fretting tribocorrosion properties of anodized TiNbSn implant alloy
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Kubota, M., Masahashi, N., Inoue, H., Michiyama, Y., Ohmura, K., and Hanada, S.
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- 2023
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4. A Prospective Observational Study of Osimertinib for Chemo-Naive Elderly Patients with EGFR Mutation-Positive Non-Small Cell Lung Cancer
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Igawa S, Kasajima M, Ono T, Ozawa T, Kakegawa M, Kusuhara S, Sato T, Nakahara Y, Fukui T, Yokoba M, Kubota M, Mitsufuji H, Sasaki J, and Naoki K
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non-small cell lung carcinoma ,chemotherapy-naïve patients ,efficacy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Satoshi Igawa,1 Masashi Kasajima,1 Taihei Ono,1 Takahiro Ozawa,1 Mikiko Kakegawa,1 Seiichiro Kusuhara,1 Takashi Sato,1 Yoshiro Nakahara,1 Tomoya Fukui,1 Masanori Yokoba,2 Masaru Kubota,2 Hisashi Mitsufuji,3 Jiichiro Sasaki,4 Katsuhiko Naoki1 1Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara-city, Kanagawa, Japan; 2School of Allied Health Sciences, Kitasato University, Sagamihara-city, Kanagawa, Japan; 3Kitasato University School of Nursing, Sagamihara-city, Kanagawa, Japan; 4Kitasato University School of Medicine, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara-city, Kanagawa, JapanCorrespondence: Satoshi IgawaDepartment of Respiratory Medicine, Kitasato University School of Medicine, 1-15-1, Kitasato, Minami-ku, Sagamihara-city, Kanagawa, 252-0374, JapanTel +81-42-778-8506Fax +81-42-778-6412Email igawa@kitasato-u.ac.jpBackground: The clinical outcomes of elderly patients with EGFR-mutated non-small cell lung cancer (NSCLC) who are treated with osimertinib have not been sufficiently evaluated. This study aimed to assess the efficacy and safety of osimertinib in elderly chemotherapy-naive patients with NSCLC harboring sensitive EGFR mutations.Patients and Methods: We assessed the clinical effects of osimertinib as a first-line treatment for elderly NSCLC patients (≥ 75 years of age) with an exon 19 deletion or exon 21 L858R mutation in EGFR. All patients were administered 80 mg/day osimertinib as initial treatment.Results: Forty-three patients (24 women and 19 men) with adenocarcinoma who were treated between August 2018 and July 2021 were included in this study; their median age was 79 years (range, 75– 90 years). The overall objective response rate was 60.5%. The median progression-free survival (PFS) and time to treatment failure (TTF) of the entire patient population were 22.1 months and 14.6 months, respectively. The most common adverse event was rash acneiform (42%), followed by diarrhea (33%) and paronychia (28%); none of these were grades ≥ 3. Interstitial lung disease developed in 8 patients (18.6%); however, no treatment-related deaths occurred. Multivariate analysis identified performance status and disease stage as predictors of PFS and TTF.Conclusion: Considering the findings of this study and despite an observed discordance between PFS and TTF, osimertinib appears to be an effective and safe treatment option in elderly patients with advanced NSCLC harboring sensitive EGFR mutations. To obtain conclusive results, further studies in a larger elderly population are warranted.Keywords: non-small cell lung carcinoma, chemotherapy-naïve patients, efficacy
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- 2021
5. Performance of the PRAXyS X-ray Polarimeter
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Iwakiri, W. B., Black, J. K., Cole, R., Enoto, T., Hayato, A., Hill, J. E., Jahoda, K., Kaaret, P., Kitaguchi, T., Kubota, M., Marlowe, H., McCurdy, R., Takeuchi, Y., and Tamagawa, T.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The performance of the Time Projection Chamber (TPC) polarimeter for the Polarimeter for Relativistic Astrophysical X-ray Sources (PRAXyS) Small Explorer was evaluated using polarized and unpolarized X-ray sources. The PRAXyS mission will enable exploration of the universe through X-ray polarimetry in the 2-10 keV energy band. We carried out performance tests of the polarimeter at the Brookhaven National Laboratory, National Synchrotron Light Source (BNL-NSLS) and at NASA's Goddard Space Flight Center. The polarimeter was tested with linearly polarized, monochromatic X-rays at 11 different energies between 2.5 and 8.0 keV. At maximum sensitivity, the measured modulation factors at 2.7, 4.5 and 8.0 keV are 27%, 43% and 59%, respectively and the measured angle of polarization is consistent with the expected value at all energies. Measurements with a broadband, unpolarized X-ray source placed a limit of less than 1% on false polarization in the PRAXyS polarimeter., Comment: 8 pages, 10 figures, accepted for Nuclear Instruments and Methods in Physics Research A
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- 2016
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6. Thermal generation of spin current in an antiferromagnet
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Seki, S., Ideue, T., Kubota, M., Kozuka, Y., Takagi, R., Nakamura, M., Kaneko, Y., Kawasaki, M., and Tokura, Y.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
Longitudinal spin Seebeck effect has been investigated for an uniaxial antiferromagnetic insulator Cr2O3, characterized by a spin-flop transition under magnetic field along the c-axis. We have found that temperature gradient applied normal to Cr2O3/Pt interface induces inverse spin Hall voltage of spin current origin in Pt, whose magnitude turns out to be always proportional to magnetization in Cr2O3. The observed voltage shows significant enhancement for the lower temperature region, which can be ascribed to the phonon-drag effect on the relevant spin excitations. The above results establish that antiferromagnetic spin waves with high frequency above 100 GHz can be an effective carrier of spin current., Comment: 5 pages, 4 figures
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- 2015
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7. Nonreciprocal spin wave propagation in chiral-lattice ferromagnets
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Seki, S., Okamura, Y., Kondou, K., Shibata, K., Kubota, M., Takagi, R., Kagawa, F., Kawasaki, M., Tatara, G., Otani, Y., and Tokura, Y.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Spin current, i.e. the flow of spin angular momentum or magnetic moment, has recently attracted much attention as the promising alternative for charge current with better energy efficiency. Genuine spin current is generally carried by the spin wave (propagating spin precession) in insulating ferromagnets, and should hold the chiral symmetry when it propagates along the spin direction. Here, we experimentally demonstrate that such a spin wave spin current (SWSC) shows nonreciprocal propagation characters in a chiral-lattice ferromagnet. This phenomenon originates from the interference of chirality between the SWSC and crystal-lattice, which is mediated by the relativistic spin-orbit interaction. The present finding enables the design of perfect spin current diode, and highlights the importance of the chiral aspect in SWSC., Comment: 23 pages, 7 figures
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- 2015
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8. Discretized Topological Hall Effect Emerging from Skyrmions in Constricted Geometry
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Kanazawa, N., Kubota, M., Tsukazaki, A., Kozuka, Y., Takahashi, K. S., Kawasaki, M., Ichikawa, M., Kagawa, F., and Tokura, Y.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We investigate the skyrmion formation process in nano-structured FeGe Hall-bar devices by measurements of topological Hall effect, which extracts the winding number of a spin texture as an emergent magnetic field. Step-wise profiles of topological Hall resistivity are observed in the course of varying the applied magnetic field, which arise from instantaneous changes in the magnetic nano-structure such as creation, annihilation, and jittering motion of skyrmions. The discrete changes in topological Hall resistivity demonstrate the quantized nature of emergent magnetic flux inherent in each skyrmion, which had been indistinguishable in many-skyrmion systems on a macroscopic scale.
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- 2015
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9. Impact of Amrubicin Monotherapy as Second-Line Chemotherapy on Outcomes in Elderly Patients with Relapsed Extensive-Disease Small-Cell Lung Cancer
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Igawa S, Ono T, Kasajima M, Manabe H, Fukui T, Mitsufuji H, Yokoba M, Kubota M, Katagiri M, Sasaki J, and Naoki K
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small cell lung cancer ,amrubicin ,elderly ,second-line chemotherapy ,modified glasgow prognostic score ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Satoshi Igawa,1 Taihei Ono,1 Masashi Kasajima,1 Hideaki Manabe,1 Tomoya Fukui,1 Hisashi Mitsufuji,2 Masanori Yokoba,3 Masaru Kubota,3 Masato Katagiri,3 Jiichiro Sasaki,4 Katsuhiko Naoki1 1Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara-City, Kanagawa 252-0374, Japan; 2Kitasato University School of Nursing, Sagamihara-City, Kanagawa 252-0329, Japan; 3School of Allied Health Sciences, Kitasato University, Sagamihara-City, Kanagawa 252-0373, Japan; 4Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara-City, Kanagawa 252-0374, JapanCorrespondence: Satoshi IgawaDepartment of Respiratory Medicine, Kitasato University School of Medicine, 1-15-1, Kitasato, Minami-Ku, Sagamihara-City, Kanagawa 252-0374, JapanTel +81 42 778 8506Fax +81 42 778 6412Email igawa@kitasato-u.ac.jpPurpose: Amrubicin (AMR) is an anticancer drug for patients with relapsed small-cell lung cancer (SCLC). However, the efficacy of AMR in elderly patients with relapsed SCLC after chemotherapy by carboplatin plus etoposide (CE) has not been sufficiently evaluated.Patients and Methods: The medical records of patients with relapsed SCLC who received AMR as second-line chemotherapy were retrospectively reviewed, and their treatment outcomes were evaluated.Results: Forty-one patients with a median age of 76 years were analyzed. The overall response rate was 26.8%. Median progression-free survival (PFS) and overall survival (OS) were 3.5 and 8.1 months, respectively. While the median PFS of 4.7 and 2.8 months in the sensitive relapse and the refractory relapse group differed significantly (P=0.043), respectively, the median OS of 10.7 and 6.8 months in the respective relapse groups did not indicate a statistically significant difference (P=0.24). The median PFS in a group with a modified Glasgow prognostic score (mGPS) of 0 and a group with a mGPS 1 or 2 were 4.5 and 1.6 months (P=0.052), respectively, and the median OS in the respective mGPS groups were 10.7 and 4.4 months (P=0.034). Multivariate analysis identified good performance status, limited disease, and mGPS 0 as favorable independent predictors of PFS and OS of AMR monotherapy. Grade 3 or higher neutropenia was observed in 23 patients (56%), and febrile neutropenia was observed in nine patients (22%). Non-hematological toxic effects were relatively mild, and pneumonitis and treatment-related deaths were not observed.Conclusion: AMR is an effective and feasible regimen for elderly patients with relapsed SCLC after CE therapy.Keywords: small-cell lung cancer, amrubicin, elderly, second-line chemotherapy, modified Glasgow prognostic score
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- 2020
10. Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks
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Asada-Utsugi, M., Uemura, K., Kubota, M., Noda, Y., Tashiro, Y., Uemura, T. M., Yamakado, H., Urushitani, M., Takahashi, R., Hattori, S., Miyakawa, T., Ageta-Ishihara, N., Kobayashi, K., Kinoshita, M., and Kinoshita, A.
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- 2021
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11. Angle-resolved photoemission spectroscopy study of PrFeAsO_{0.7}: Dependence of the electronic structure on the pnictogen height
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Nishi, I., Ishikado, M., Ideta, S., Malaeb, W., Yoshida, T., Fujimori, A., Kotani, Y., Kubota, M., Ono, K., Yi, M., Lu, D. H., Moore, R., Shen, Z. -X., Iyo, A., Kihou, K., Kito, H., Eisaki, H., Shamoto, S., and Arita, R.
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Condensed Matter - Superconductivity - Abstract
We have performed an angle-resolved photoemission spectroscopy (ARPES) study of the iron-based superconductor PrFeAsO_{0.7} and examined the Fermi surfaces and band dispersions near the Fermi level. Heavily hole-doped electronic states have been observed due to the polar nature of the cleaved surfaces. Nevertheless, we have found that the ARPES spectra basically agree with band dispersions calculated in the local density approximation (LDA) if the bandwidth is reduced by a factor of ~2.5 and then the chemical potential is lowered by ~70 meV. Comparison with previous ARPES results on LaFePO reveals that the energy positions of the d_{3z^2-r^2}- and d_{yz,zx}-derived bands are considerably different between the two materials, which we attribute to the different pnictogen height as predicted by the LDA calculation.
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- 2011
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12. Two- and Three-Dimensional Fermi Surfaces and their Nesting Properties in Superconducting BaFe2(As1-xPx)2
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Yoshida, T., Nishi, I., Ideta, S., Fujimori, A., Kubota, M., Ono, K., Kasahara, S., Shibauchi, T., Terashima, T., Matsuda, Y., Ikeda, H., and Arita, R.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We have studied the three-dimensional shapes of the Fermi surfaces (FSs) of BaFe2(As1-xPx)2 (x=0.38), where superconductivity is induced by isovalent P substitution, by angle-resolved photoemission spectroscopy. Moderately strong electron mass enhancement has been identified for both the electron and hole FSs. Among two observed hole FSs, the nearly two-dimensional one shows good nesting with the outer two-dimensional electron FS, but its orbital character is different from the outer electron FS. The three-dimensional hole FS shows poor nesting with the electron FSs. The present results suggest that the three-dimensionality and the difference in the orbital character weaken FS nesting, leaving partial nesting among the outer electron FSs of dxy character and/or that within the three-dimensional hole FS, which may lead to the nodal superconductivity., Comment: 4 pages, 4 figures
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- 2010
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13. Mass renormalization in the band width-controlled Mott-Hubbard systems SrVO3 and CaVO3 studied by angle-resolved photoemission spectroscopy
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Yoshida, T., Hashimoto, M., Takizawa, T., Fujimori, A., Kubota, M., Ono, K., and Eisaki, H.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Ca1-xSrxVO3 is a Mott-Hubbard-type correlated electron system whose bandwidth can be varied by the V-O-V bond angle, but the actual effect of bandwidth control on the electronic structure has been controversial in previous photoemission experiments. In this work, band dispersions and Fermi surfaces of SrVO3 and CaVO3 are studied by angle-resolved photoemission spectroscopy. Near the Fermi level (EF), three bands forming cylindricalFermi surfaces derived from the three V 3d t2g orbitals have been observed. The observed band widths for both compounds are almost half of those predicted by local-density-approximation band-structure calculation, confirming mass renormalization caused by electron correlation. It has been clearly demonstrated that the width of the d band in CaVO3 is narrower than that in SrVO3, qualitatively consistent with the result of band-structure calculation. Roles of the orthorhombic lattice distortion and electron correlation in the observed band narrowing are discussed., Comment: 13 pages, 5 figures
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- 2010
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14. Characteristic electronic structure and its doping evolution in lightly-doped to underdoped YBa2Cu3Oy
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Yagi, H., Yoshida, T., Fujimori, A., Tanaka, K., Mannella, N., Yang, W. L., Zhou, X. J., Lu, D. H., Shen, Z. -X., Hussain, Z., Kubota, M., Ono, K., Segawa, K., Ando, Y., Iijima, D., Goto, M., Kojima, K. M., and Uchida, S.
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Condensed Matter - Superconductivity - Abstract
We have performed an angle resolved photoemission spectroscopy (ARPES) study of lightly-doped to underdoped YBa2Cu3Oy (YBCO) untwinned single crystals and a core-level x-ray photoemission spectroscopy (XPS) study of YBCO single and polycrystals. In the zone diagonal (nodal) direction, dispersive quasi-particle (QP) features crossing the Fermi level were observed down to the hole concentration of ~ 4%, which explains the metallic transport of the lightly-doped YBCO. The chemical potential shift estimated from XPS was more rapid than in the Bi2212 cuprates. Upon hole doping, very rapid spectral weight transfer from high binding energies to the QP feature, even faster than La2-xSrxCuO4, was observed., Comment: 7 pages, 7 figures
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- 2010
15. Enhanced superconducting gaps in the tri-layer high-$T_c$ cuprate Bi$_2$Sr$_2$Ca$_2$Cu$_3$O$_{10+\delta}$
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Ideta, S., Takashima, K., Hashimoto, M., Yoshida, T., Fujimori, A., Anzai, H., Fujita, T., Nakashima, Y., Ino, A., Arita, M., Namatame, H., Taniguchi, M., Ono, K., Kubota, M., Lu, D. H., Shen, Z. -X., Kojima, K. M., and Uchida, S.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We have investigated the optimally doped tri-layer cuprate Bi$_2$Sr$_2$Ca$_2$Cu$_3$O$_{10+\delta}$ (Bi2223) by angle-resolved photoemission spectroscopy, and observed energy bands and Fermi surfaces originated from the outer and inner CuO$_2$ planes (OP and IP) separately. The OP band is overdoped (hole density $\sim$ 0.26/Cu) with a large d-wave gap of $\Delta_0$ $\sim$ 43 meV while the IP is underdoped ($\sim$ 0.06/Cu) with an even large gap of $\Delta_0$ $\sim$ 60 meV. We propose that the enhancement of the $\Delta_0$ of IP is due to the minimal influence of out-of-plane disorder and that the OP gap is then enhanced through interlayer coupling, most likely a proximity effect from the IP., Comment: 5 pages, 4 figures
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- 2009
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16. Differences in the high-energy kink between hole- and electron-doped high-$T_{\rm c}$ superconductors
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Ikeda, M., Yoshida, T., Fujimori, A., Kubota, M., Ono, K., Kaga, Y., Sasagawa, T., and Takagi, H.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We have performed an angle-resolved photoemission spectroscopy (ARPES) study of Nd$_{1.85}$Ce$_{0.15}$CuO$_{4}$ (NCCO) in order to elucidate the origin of the high-energy kink (HEK) observed in the high-$T_{\rm c}$ superconductors (HTSCs). The energy scale of the HEK in NCCO is large compared with that in hole-doped HTSCs, consistent with previous ARPES studies. From measurement in a wide momentum region, we have demonstrated that between the hole- and electron-doped HTSCs the energy position of the HEK is shifted approximately by the amount of the chemical potential difference. Also, we have found that around $(\pi, 0)$ the HEK nearly coincides with the band bottom while around the node the band reaches the incoherent region and the HEK appears at the boundary between the coherent and incoherent regions., Comment: 5 pages, 3 figures
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- 2009
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17. Universal versus Material-Dependent Two-Gap Behaviors in the High-Tc Cuprates: Angle-Resolved Photoemission Study of La2-xSrxCuO4
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Yoshida, T., Hashimoto, M., Ideta, S., Fujimori, A., Tanaka, K., Mannella, N., Hussain, Z., Shen, Z. -X., Kubota, M., Ono, K., Komiya, Seiki, Ando, Yoichi, Eisaki, H., and Uchida, S.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity - Abstract
We have investigated the doping and temperature dependences of the pseudogap/superconducting gap in the single-layer cuprate La$_{2-x}$Sr$_x$CuO$_4$ by angle-resolved photoemission spectroscopy. The results clearly exhibit two distinct energy and temperature scales, namely, the gap around ($\pi$,0) of magnitude $\Delta^*$ and the gap around the node characterized by the d-wave order parameter $\Delta_0$, like the double-layer cuprate Bi2212. In comparison with Bi2212 having higher $T_c$'s, $\Delta_0$ is smaller, while $\Delta^*$ and $T^*$ are similar. This result suggests that $\Delta^*$ and $T^*$ are approximately material-independent properties of a single CuO$_2$ plane, in contrast the material-dependent $\Delta_0$, representing the pairing strength., Comment: 5 pages, 4 figures
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- 2008
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18. Effects of out-of-plane disorder on the nodal quasiparticle and superconducting gap in single-layer Bi$_2$Sr$_{1.6}Ln_{0.4}$CuO$_{6+\delta}$ ($Ln$ = La, Nd, Gd)
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Hashimoto, M., Yoshida, T., Fujimori, A., Lu, D. H., Shen, Z. -X., Kubota, M., Ono, K., Ishikado, M., Fujita, K., and Uchida, S.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
How out-of-plane disorder affects the electronic structure has been investigated for the single-layer cuprates Bi$_2$Sr$_{1.6}$$Ln$$_{0.4}$CuO$_{6+\delta}$ ($Ln$ = La, Nd, Gd) by angle-resolved photoemission spectroscopy. We have observed that, with increasing disorder, while the Fermi surface shape and band dispersions are not affected, the quasi-particle width increases, the anti-nodal gap is enhanced and the superconducting gap in the nodal region is depressed. The results indicate that the superconductivity is significantly depressed by out-of-plane disorder through the enhancement of the anti-nodal gap and the depression of the superconducting gap in the nodal region.
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- 2008
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19. Impact of EGFR genotype on the efficacy of osimertinib in EGFR tyrosine kinase inhibitor-resistant patients with non-small cell lung cancer: a prospective observational study
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Igawa S, Ono T, Kasajima M, Ishihara M, Hiyoshi Y, Kusuhara S, Nishinarita N, Fukui T, Kubota M, Sasaki J, Hisashi M, Yokoba M, Katagiri M, and Naoki K
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EGFR genotype ,non-small cell lung carcinoma ,osimertinib ,efficacy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Satoshi Igawa,1 Taihei Ono,1 Masashi Kasajima,1 Mikiko Ishihara,1 Yasuhiro Hiyoshi,1 Seiichiro Kusuhara,1 Noriko Nishinarita,1 Tomoya Fukui,1 Masaru Kubota,1 Jiichiro Sasaki,2 Mitsufuji Hisashi,3 Masanori Yokoba,4 Masato Katagiri,4 Katsuhiko Naoki11Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara-city, Kanagawa, Japan; 2Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara-city, Kanagawa, Japan; 3Kitasato University School of Nursing, Sagamihara-city, Kanagawa, Japan; 4School of Allied Health Sciences, Kitasato University, Sagamihara-city, Kanagawa 252-0373, JapanPurpose: A T790M of the epidermal growth factor receptor (EGFR) is the most frequently encountered mutation conferring acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). The aim of this study was to assess the differential clinical outcomes of osimertinib therapy in NSCLC patients with T790M according to the type of activating EGFR mutation, ie, exon 19 deletion or L858R point mutation.Patients and methods: A prospective observational cohort study was conducted to evaluate the efficacy and safety of osimertinib in patients with a major EGFR mutation and T790M-positive advanced NSCLC who had disease progression after first-line EGFR-TKI therapy. The efficacy of osimertinib was evaluated according to the type of EGFR mutation.Results: A total of 51 patients were included in this study. An objective response was obtained in 29 patients, indicating an objective response rate of 58.8%. The response rate was 69.7% in patients with exon 19 deletion and 38.9% in patients with L858R point mutation, indicating a statistically significant difference (P=0.033). The median progression-free survival (PFS) and overall survival (OS) of the entire patient population were 7.8 and 15.5 months, respectively. The median PFS in the exon 19 deletion and L858R point mutation groups was 8.0 months and 5.2 months, respectively, indicating a statistically significant difference (P=0.045). Median OS in the exon 19 deletion and L858R point mutation groups was significantly different at 19.8 months and 12.9 months, respectively (P=0.0015). Multivariate analysis identified the exon 19 deletion as a favorable independent predictor of PFS and OS.Conclusion: Investigators should consider the proportions of sensitive EGFR mutation types as a stratification factor in designing or reviewing clinical studies involving osimertinib.Keywords: EGFR genotype, non-small cell lung carcinoma, osimertinib, efficacy
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- 2019
20. Observation of Coherent Precession of Magnetization in Superfluid 3He A-phase
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Sato, T., Kunimatsu, T., Izumina, K., Matsubara, A., Kubota, M., Mizusaki, T., and Bunkov, Yu. M.
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Condensed Matter - Other Condensed Matter - Abstract
We report the first observation of coherent quantum precession of magnetization (CQP) in superfluid 3He-A in aerogel. The coherent precession in bulk 3He A-phase is unstable due to the positive feedback of spin supercurrent to the gradient of phase of precession. It was predicted that the homogeneous precession will be stable if the orbital momentum of 3He-A could be oriented along the magnetic field. We have succeeded to prepare this configuration by emerging 3He in uniaxially-deformed anisotropic aerogel. The dissipation rate of coherent precession states in aerogel is much larger then one in bulk 3He-B. We propose a mechanism of this dissipation., Comment: 4 pages, 4 figures
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- 2008
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21. Effects of chemical pressure on the Fermi surface and band dispersion in the electron-doped high-Tc superconductors
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Ikeda, M., Yoshida, T., Fujimori, A., Kubota, M., Ono, K., Das, Hena, Saha-Dasgupta, T., Unozawa, K., Kaga, Y., Sasagawa, T., and Takagi, H.
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Condensed Matter - Superconductivity - Abstract
We have performed angle-resolved photoemission spectroscopy (ARPES) measurements and first-principles electronic structure calculations on the electron-doped high-Tc superconductors Ln1.85Ce0.15CuO4 (Ln = Nd, Sm, and Eu). The observed Fermi surface and band dispersion show such changes that with decreasing ionic size of Ln3+, the curvature of the Fermi surface or -t'/t decreases, where t and t' are transfer integrals between the nearest-neighbor and next-nearestneighbor Cu sites, respectively. The increase of t with chemical pressure is found to be significant, which may explain the apparently inconsistent behavior seen in the hole-doped La2-xSrxCuO4 under epitaxial strain [M. Abrecht et al., Phys. Rev. Lett. 91, 057002 (2003)]. A gap due to the antiferromagnetism opens even in the nodal region for the Sm and Eu compounds, and the gap size increases in going from Ln = Sm to Eu., Comment: 4 pages, 4 figures
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- 2008
22. Doping evolution of the electronic structure in the single-layer cuprates Bi$_2$Sr$_{2-x}$La$_x$CuO$_{6+\delta}$: Comparison with other single-layer cuprates
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Hashimoto, M., Yoshida, T., Yagi, H., Takizawa, M., Fujimori, A., Kubota, M., Ono, K., Tanaka, K., Lu, D. H., Shen, Z. -X., Ono, S., and Ando, Yoichi
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We have performed angle-resolved photoemission and core-level x-ray photoemission studies of the single-layer cuprate Bi$_2$Sr$_{2-x}$La$_x$CuO$_{6+\delta}$ (Bi2201) and revealed the doping evolution of the electronic structure from the lightly-doped to optimally-doped regions. We have observed the formation of the dispersive quasi-particle band, evolution of the Fermi ``arc'' into the Fermi surface and the shift of the chemical potential with hole doping as in other cuprates. The doping evolution in Bi2201 is similar to that in Ca$_{2-x}$Na$_{x}$CuO$_{2}$Cl$_2$ (Na-CCOC), where a rapid chemical potential shift toward the lower Hubbard band of the parent insulator has been observed, but is quite different from that in La$_{2-x}$Sr$_{x}$CuO$_{4}$ (LSCO), where the chemical potential does not shift, yet the dispersive band and the Fermi arc/surface are formed around the Fermi level already in the lightly-doped region. The (underlying) Fermi surface shape and band dispersions are quantitatively analyzed using tight-binding fit, and the deduced next-nearest-neighbor hopping integral $t'$ also confirm the similarity to Na-CCOC and the difference from LSCO.
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- 2008
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23. Real-world evaluation of carboplatin plus a weekly dose of nab-paclitaxel for patients with advanced non-small-cell lung cancer with interstitial lung disease
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Igawa S, Nishinarita N, Takakura A, Ozawa T, Harada S, Kusuhara S, Niwa H, Hosotani S, Sone H, Nakahara Y, Fukui T, Mitsufuji H, Yokoba M, Kubota M, Katagiri M, Sasaki J, and Naoki K
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Interstitial Lung Disease ,Non-Small cell lung cancer ,Carboplatin ,Nab-Paclitaxel ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Satoshi Igawa,1 Noriko Nishinarita,1 Akira Takakura,1 Takahiro Ozawa,1 Shinya Harada,1 Seiichiro Kusuhara,1 Hideyuki Niwa,2 Shinji Hosotani,1 Hideyuki Sone,1 Yoshiro Nakahara,1,3 Tomoya Fukui,1 Hisashi Mitsufuji,4 Masanori Yokoba,5 Masaru Kubota,1 Masato Katagiri,5 Jiichiro Sasaki,6 Katsuhiko Naoki1 1Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara 252-0374, Kanagawa, Japan; 2Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya 460-0001, Aichi, Japan; 3Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Kanagawa, Japan; 4Kitasato University School of Nursing, Sagamihara 252-0329, Kanagawa, Japan; 5School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan; 6Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara 252-0374, Kanagawa, Japan Background: The optimal chemotherapy regimen for non-small-cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) remains unknown. Therefore, in this study, we investigated the real-world efficacy and safety of carboplatin (CBDCA) plus nab-paclitaxel (nab-PTX) as a first-line regimen for NSCLC patients with ILD. Patients and methods: We retrospectively reviewed advanced NSCLC patients with ILD who had received CBDCA plus nab-PTX as a first-line chemotherapy regimen between April 2013 and March 2018. Patients were diagnosed with ILD based on the findings of a pretreatment high-resolution computed tomography of the chest. Results: The 34 patients enrolled in this study were included in the efficacy and safety analysis. Collagen vascular disease or a history of exposure to dust or asbestos was not reported for any patients. The median age of patients was 71 years (range, 59–83 years), and 32 patients had a performance status of 0 or 1. The overall response rate was 38.2%. The median progression-free survival and overall survival were 5.8 months and 12.7 months, respectively. Chemotherapy-related acute exacerbation of ILD was observed in two patients (5.7%). Other toxicities were feasible, and no treatment-related deaths occurred. Conclusion: CBDCA plus nab-PTX, as a first-line chemotherapy regimen for NSCLC, showed favorable efficacy and safety in patients with preexisting ILD. Keywords: interstitial lung disease, non-small-cell lung cancer, carboplatin, nab-paclitaxel
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- 2018
24. Annealing Effect for Supersolid Fraction in $^4$He
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Penzev, A., Yasuta, Y., and Kubota, M.
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Condensed Matter - Other Condensed Matter - Abstract
We report on experimental confirmation of the non-classical rotational inertia (NCRI) in solid helium samples originally reported by Kim and Chan. The onset of NCRI was observed at temperatures below ~400 mK. The ac velocity for initiation of the NCRI suppression is estimated to be ~10 $\mu$m/sec. After an additional annealing of the sample at $T= 1.8$ K for 12 hours, ~ 10% relative increase of NCRI fraction was observed. Then after repeated annealing with the same conditions, the NCRI fraction was saturated. It differs from Reppy's observation on a low pressure solid sample., Comment: to be published in J. of Low Temp. Phys. (QFS2006 proceedings)
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- 2007
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25. Lanthanide substitution effects in electron-doped high-Tc superconductors studied by angle-resolved photoemission spectroscopy
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Ikeda, M., Yoshida, T., Fujimori, A., Kubota, M., Ono, K., Unozawa, K., Sasagawa, T., and Takagi, H.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We have performed an angle-resolved photoemission study of the electron-doped high-Tc superconductors (HTSCs) Sm_{1.85}Ce_{0.15}CuO_{4} (SCCO) and Eu_{1.85}Ce_{0.15}CuO_{4} (ECCO). Around the nodal point (pi/2, pi/2), we observed an energy gap at the Fermi level (EF) for both samples, resulting from the strong effects of antiferromagnetism. The magnitude of this gap in ECCO is larger than that in SCCO, implying that the effects of antiferromagnetism in ECCO are stronger than that in SCCO. Also, we quantitatively confirmed the effects of antiferromagnetism by the band dispersions to tight-binding calculation., Comment: submitted to J. of Superconductivity (Proceedings of Stripes 2006)
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- 2006
26. NMR of superfluid 3He in anisotropic aerogel
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Kunimatsu, T., Sato, T., Izumina, K., Matsubara, A., Sasaki, Y., Kubota, M., Ishikawa, O., Mizusaki, T., and Bunkov, Yu. M.
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Condensed Matter - Other Condensed Matter - Abstract
We report on orientation of the order parameter in the 3He-A and 3He-B phases caused by aerogel anisotropy. In 3He-A we have observed relatively homogeneous NMR line with an anomalously large negative frequency shift. We can attribute this effect to an orientation of orbital momentum along the axis of density anisotropy. The similar orientation effect we have seen in 3He-B. We can measure the A-phase Leggett frequency, which shows the same energy gap suppression as in the B-phase. We observe a correlation of A - B transition temperature and NMR frequency shift., Comment: 4 pages, 4 figures, submited to Phys. Rev. Letters
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- 2006
27. Bulk and surface low-energy excitations in YBa2Cu3O7-d studied by high-resolution angle-resolved photoemission spectroscopy
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Nakayama, K., Sato, T., Terashima, K., Matsui, H., Takahashi, T., Kubota, M., Ono, K., Nishizaki, T., Takahashi, Y., and Kobayashi, N.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We have performed high-resolution angle-resolved photoemission spectroscopy on YBa2Cu3O7-delta (Y123; delta = 0.06; Tc = 92 K). By accurately determining the Fermi surface and energy band dispersion, we solve long-standing controversial issues as to the anomalous electronic states of Y-based high-Tc cuprates. We unambiguously identified surface-bilayer-derived bonding and antibonding bands, together with their bulk counterparts. The surface bands are highly overdoped (hole concentration x = 0.29), showing no evidence for the gap opening or the dispersion anomaly in the antinodal region, while the bulk bands show a clear dx2-y2-wave superconducting gap and the Bogoliubov quasiparticle-like behavior with a characteristic energy scale of 50-60 meV indicative of a strong electron-boson coupling in the superconducting state. All these results suggest that the metallic and superconducting states coexist at the adjacent bilayer of Y123 surface., Comment: Accepted for publication in Phys. Rev. B
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- 2006
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28. Rotation-induced 3D vorticity in 4He superfluid films adsorbed on a porous glass
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Fukuda, M., Zalalutdinov, M. K., Kovacik, V., Minoguchi, T., Obata, T., Kubota, M., and Sonin, E. B.
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Condensed Matter - Other Condensed Matter - Abstract
Detailed study of torsional oscillator experiments under steady rotation up to 6.28 rad/sec is reported for a 4He superfluid monolayer film formed in 1 micrometer-pore diameter porous glass. We found a new dissipation peak with the height being in proportion to the rotation speed, which is located to the lower temperature than the vortex pair unbinding peak observed in the static state. We propose that 3D coreless vortices ("pore vortices") appear under rotation to explain this new peak. That is, the new peak originates from dissipation close to the pore vortex lines, where large superfluid velocity shifts the vortex pair unbinding dissipation to lower temperature. This explanation is confirmed by observation of nonlinear effects at high oscillation amplitudes., Comment: 4pages, 5figures
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- 2004
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29. Spectroscopic Signatures on Increase in Charge-Density-Wave Potential of 1{\em T}-TaS$_{1.2}$Se$_{0.8}$
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Aiura, Y., Hase, I., Bando, H., Yagi-Watanabe, K., Tanaka, K., Ozawa, K., Iwase, T., Nishihara, Y., Shiino, O., Oshima, M., Kubota, M., and Ono, K.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We present an angle-resolved photoemission (ARPES) study on the layered transition-metal dichalcogenide 1{\em T}-TaS$_{1.2}$Se$_{0.8}$ in the metallic commensurate charge-density-wave (CDW) phase. A model calculation of the spectral function captures the main features of the ARPES spectra well qualitatively, that is, the gross splits of unreconstructed band structure in the absence of the CDW superlattice. The observed enhancement of the size of the gap between the lower and middle fragments of the Ta {\em 5d} band along the $\Gamma$M line by cooling is interpreted in terms of the increase in the CDW-related potential., Comment: 5 pages, 4 figures
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- 2003
30. Age-dependent hepatic alterations induced by a high-fat high-fructose diet
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Casagrande, B. P., Gomes, M. F. P., Moura, E. O. C., Santos, A. C. C., Kubota, M. C., Ribeiro, D. A., Pisani, L. P., Medeiros, A., and Estadella, D.
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- 2019
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31. Calculation of the Phase Field of a Vortex Pair on the Surface of a Multiplly Connected Substrate
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Obata, T. and Kubota, M.
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Statistical Mechanics - Abstract
The vortex pair phase field is calculated, through a solution of the Laplace equation, for a superfluid film adsorbed on the surface of a model 3D connected porous medium. A number of different vortex-antivortex pair configurations are considered as functions of the porosity or an aspect ratio of the model porous structure. The calculated results give the energy of a pair for motion of the vortex cores around a pore or a solid rod as well as for the string configuration corresponding to a linear separation of the vortex pair through the porous medium., Comment: 5 pages, 13 figures, revtex4
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- 2002
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32. Rates of neutrino conversion and decay in hot and dense QED plasma
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Asida, N., Niégawa, A., Ozaki, H., and Kubota, M.
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High Energy Physics - Phenomenology - Abstract
Using a real-time formalism of equilibrium and nonequilibrium quantum-field theory, we derive the reaction-rate formula for neutrino-conversion ($\nu \to \nu'$) process and $\nu \bar{\nu}'$ annihilation process, which take place in a hot and dense QED plasma with background (anti)neutrinos out of equilibrium. Also derived is the formula for the inverse processes to the above ones. Using the hard-thermal-loop resummation scheme, we include the contribution from the coherent processes. The decay/production of a neutrino causes an evolution of its spatial distribution. A scheme for dealing with this evolution is presented. For the case of isotropic neutrino distribution, numerical computation is carried out for the parameter region of type-II super-nova explosion. Defferential reaction rate exhibits characteristic peak structure, which comes from the coherent processes. The contribution from the above processes to the decay or damping rate of a parent neutrino $\nu$ is also studied., Comment: 27 pages and 13 figures
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- 2001
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33. Highly Degenerate Canted Spin Structure in Bilayer Manganite La$_{1.1}$Sr$_{1.9}$Mn$_2$O$_7$
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Kubota, M., Oohara, Y., Yoshizawa, H., Fujioka, H., Hirota, K., Moritomo, Y., and Endoh, Y.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We have examined magnetic ordering of the two-dimensional (2D) bilayer manganite La$_{1.1}$Sr$_{1.9}$Mn$_2$O$_7$ with neutron diffraction technique. Due to the two-dimensionality, there appears intense 2D ridge scattering along the tetragonal $(00l)$ direction, and the analyses of such scattering leads to a conclusion that the low temperature spin structure is a canted antiferromagnetic ordering., Comment: 4 pages, 3 figures Email: mkubota@post.kek.jp
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- 2001
34. Spin dynamical properties and orbital states of the layered perovskite La_2-2x_Sr_1+2x_Mn_2_O_7 (0.3 <= x < 0.5)
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Hirota, K., Ishihara, S., Fujioka, H., Kubota, M., Yoshizawa, H., Moritomo, Y., Endoh, Y., and Maekawa, S.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Low-temperature spin dynamics of the double-layered perovskite La_2-2x_Sr_1+2x_Mn_2_O_7 (LSMO327) was systematically studied in a wide hole concentration range (0.3 <= x < 0.5). The spin-wave dispersion, which is almost perfectly 2D, has two branches due to a coupling between layers within a double-layer. Each branch exhibits a characteristic intensity oscillation along the out-of-plane direction. We found that the in-plane spin stiffness constant and the gap between the two branches strongly depend on x. By fitting to calculated dispersion relations and cross sections assuming Heisenberg models, we have obtained the in-plane (J_para), intra-bilayer (J_perp) and inter-bilayer (J') exchange interactions at each x. At x=0.30, J_para=-4meV and J_perp=-5meV, namely almost isotropic and ferromagnetic. Upon increasing x, J_perp rapidly approaches zero while |J_para| increases slightly, indicating an enhancement of the planar magnetic anisotropy. At x=0.48, J_para reaches -9meV, while J_perp turns to +1meV indicating an antiferromagnetic interaction. Such a drastic change of the exchange interactions can be ascribed to the change of the relative stability of the d_x^2-y^2 and d_3z^2-r^2 orbital states upon doping. However, a simple linear combination of the two states results in an orbital state with an orthorhombic symmetry, which is inconsistent with the tetragonal symmetry of the crystal structure. We thus propose that an ``orbital liquid'' state realizes in LSMO327, where the charge distribution symmetry is kept tetragonal around each Mn site., Comment: 10 pages including 7 figures
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- 2001
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35. Influence of Quasi-Bi-Stripe Charge Order on the Resistivity and Magnetism in a Bilayer Manganite La$_{2-2x}$Sr$_{1+2x}$Mn$_{2}$O$_{7}$
- Author
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Kubota, M., Oohara, Y., Yoshizawa, H., Fujioka, H., Shimizu, K., Hirota, K., Moritomo, Y., and Endoh, Y.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The charge ordering in the bilayer manganite system La$_{2-2x}$Sr$_{1+2x}$Mn$_{2}$O$_{7}$ with $0.30 \le x \le 0.50$ has been studied by neutron diffraction. The charge order is characterized by the propagation vector parallel to the [1 0 0] direction (MnO$_2$ direction), but the correlation length is short-ranged and extremely anisotropic, being $\sim 0.02a^{*}$ and $\sim 0.2a^{*}$ parallel and perpendicular to the modulation direction, respectively. The observed charge order can be viewed as a quasi-bi-stripe order, and accounts well for the $x$ dependence of the resistivity. The quasi-bistripe order is stable within the ferromagnetic (FM) MnO$_2$ layers in the A-type antiferromagnetic order, but is instabilized by the 3 dimensional FM order., Comment: 11 pages, 5 figures
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- 2000
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36. Charge and spin ordering in Nd{1/3}Sr{2/3}FeO{3}
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Kajimoto, R., Oohara, Y., Kubota, M., Yoshizawa, H., Park, S. K., Taguchi, Y., and Tokura, Y.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We have investigated the charge and spin ordering in Nd{1/3}Sr{2/3}FeO{3} with neutron diffraction technique. This sample undergoes a charge ordering transition accompanying charge disproportionation of 2Fe4+ -> Fe3+ + Fe5+. We measured the superlattice reflections due to the charge and spin ordering, and confirmed that charges and spins order simultaneously at Tco = 185 K. The ordering pattern of charges and spins in this sample can be viewed as three dimensional stripe order, and is compared with two dimensional stripe order observed in other transition metal oxides., Comment: REVTeX, 4 pages, 3 figures, to be published in J. Phys. Chem. Solids
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- 2000
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37. Relation between crystal and magnetic structures of the layered manganites La2-2xSr1+2xMn2O7 (0.30 =< x =< 0.50)
- Author
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Kubota, M., Fujioka, H., Hirota, K., Ohoyama, K., Moritomo, Y., Yoshizawa, H., and Endoh, Y.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
Comprehensive neutron-powder diffraction and Rietveld analyses were carried out to clarify the relation between the crystal and magnetic structures of La2-2xSr1+2xMn2O7 (0.30 =< x =< 0.50). The Jahn-Teller (JT) distortion of Mn-O6 octahedra, i.e., the ratio of the averaged apical Mn-O bond length to the equatorial Mn-O bond length, is Delta_JT=1.042(5) at x=0.30, where the magnetic easy-axis at low temperature is parallel to the c axis. As the JT distortion becomes suppressed with increasing x, a planar ferromagnetic structure appears at x =< 0.32, which is followed by a canted antiferromagnetic (AFM) structure at x =< 0.39. The canting angle between neighboring planes continuously increases from 0 deg (planar ferromagnet: 0.32 =< x < 0.39) to 180 deg (A-type AFM: x=0.48 where Delta_JT=1.013(5)). Dominance of the A-type AF structure with decrease of JT distortion can be ascribed to the change in the eg orbital state from d3z^2-r^2 to dx^2-y^2.
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- 1999
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38. Spin Dynamical Properties of the Layered Perovskite La1.2Sr1.8Mn2O7
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Fujioka, H., Kubota, M., Hirota, K., Yoshizawa, H., Moritomo, Y., and Endoh, Y.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Inelastic neutron-scattering measurements were performed on a single crystal of the layered colossal magnetoresistance (CMR) material La1.2Sr1.8Mn2O7 (Tc ~ 120K). We found that the spin wave dispersion is almost perfectly two-dimensional with the in-plane spin stiffness constant D ~ 151meVA. The value is similar to that of similarly doped La1-xSrxMnO3 though its Tc is three times higher, indicating a large renormalization due to low dimensionality. There exist two branches due to a coupling between layers within a double-layer. The out-of-plane coupling is about 30% of the in-plane coupling though the Mn-O bond lengths are similar., Comment: 3 pages, 3 figures J. Phys. Chem. Solids in press
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- 1999
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39. Neutron Scattering Studies on Magnetic Structure of the Double-Layered Manganite La_{2-2x}Sr_{1+2x}Mn_2O_7 ($0.30 \leq x \leq 0.50$)
- Author
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Kubota, M., Fujioka, H., Ohoyama, K., Hirota, K., Moritomo, Y., Yoshizawa, H., and Endoh, Y.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Systematic powder diffraction studies have been carried out to establish the magnetic phase diagram of La_{2-2x}Sr_{1+2x}Mn_2O_7 (LSMO327) in a wide hall concentration range ($0.30 \leq x \leq 0.50$), using the HERMES diffractometer. LSMO327 exhibits a planar ferromagnetic structure for $0.32\leq x\leq 0.38$ at low temperatures. A finite canting angle between planar magnetic moments on neighboring planes starts appearing around $x\sim 0.40$ and reaches 180$^{\circ}$ (A-type antiferromagnet) at x=0.48. At x=0.30, on the other hand, the magnetic moments are aligned parallel to the c-axis., Comment: 3 pages, 3 figures J. Phys. Chem. Solids in press
- Published
- 1999
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40. Prognostic significance of the 8th edition of the TNM classification for patients with extensive disease small cell lung cancer
- Author
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Shirasawa M, Fukui T, Kusuhara S, Hiyoshi Y, Ishihara M, Kasajima M, Nakahara Y, Otani S, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, and Naoki K
- Subjects
small cell lung cancer ,extensive disease ,TNM stage ,prognosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Masayuki Shirasawa,1,* Tomoya Fukui,1,* Seiichiro Kusuhara,1 Yasuhiro Hiyoshi,1 Mikiko Ishihara,1 Masashi Kasajima,1 Yoshiro Nakahara,1 Sakiko Otani,1 Satoshi Igawa,1 Masanori Yokoba,2 Hisashi Mitsufuji,3 Masaru Kubota,1 Masato Katagiri,1 Jiichiro Sasaki,4 Katsuhiko Naoki1 1Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan; 2Department of Medical Laboratory, Kitasato University School of Allied Health Sciences, Kanagawa, Japan; 3Fundamental Nursing, Kitasato University School of Nursing, Kanagawa, Japan; 4Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Kanagawa, Japan *These authors contributed equally to this work Background: Small cell lung cancer (SCLC) is typically categorized according to disease extent as limited or extensive, and utility of the 8th TNM classification, recommended for lung cancer staging, which demonstrates a strong association with non-small-cell lung cancer (NSCLC) management, remains unclear.Methods: This retrospective study included 277 consecutive SCLC patients treated at a single institution between 2008 and 2016.Results: According to the currently used two-stage system, 186 (65.7%) of the patients were classified as having extensive disease (ED)-SCLC. Among the ED-SCLC patients, ten (5.3%), 38 (20.4%), 32 (17.2%), and 106 (57.0%) were categorized into stages M0, M1a, M1b, and M1c, respectively, according to the 8th TNM classification. There was a significant difference in overall survival based on the M descriptors: 15.8 (95% CI 9.4–22.2) months in the M1b group vs 7.3 (95% CI 5.7–8.9) months in the M1c group (P
- Published
- 2018
41. High Speed D.C. Casting of AA-6063 Extrusion Ingot
- Author
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Nawata, S., Kubota, M., Yokota, K., Grandfield, John F., editor, and Eskin, Dmitry G., editor
- Published
- 2016
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42. Interplay of the CE-type charge ordering and the A-type spin ordering in a half-doped bilayer manganite La{1}Sr{2}Mn{2}O{7}
- Author
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Kubota, M., Yoshizawa, H., Moritomo, Y., Fujioka, H., Hirota, K., and Endoh, Y.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
We demonstrate that the half-doped bilayer manganite La_{1}Sr_{2}Mn_{2}O_{7} exhibits CE-type charge-ordered and spin-ordered states below $T_{N, CO}^A = 210$ K and below $T_{N}^{CE} \sim 145$ K, respectively. However, the volume fraction of the CE-type ordering is relatively small, and the system is dominated by the A-type spin ordering. The coexistence of the two types of ordering is essential to understand its transport properties, and we argue that it can be viewed as an effective phase separation between the metallic $d(x^{2}-y^{2})$ orbital ordering and the charge-localized $d(3x^{2}-r^{2})/d(3y^{2}-r^{2})$ orbital ordering., Comment: 5 pages, 4 figures, submitted to Phys. Rev. B
- Published
- 1998
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43. Effect of combined additions of Si, Mn, Cr and Al to carbon steel on material transfer in a steel/TiN coated tool sliding contact
- Author
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Aiso, T., Wiklund, U., Kubota, M., and Jacobson, S.
- Published
- 2017
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44. Contributors
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Ariane, M., primary, Balima, F., additional, Barthelemy, F., additional, Berger, K., additional, Bernard, F., additional, Bernstein, P., additional, Cao, G., additional, Chan, K.T., additional, Chevallier, G., additional, Chung, U.-C., additional, Cologna, M., additional, Couque, H., additional, Cury, R., additional, Cygan, S., additional, Debéda, H., additional, Delagnes, D., additional, Dupont, L., additional, Durand, L., additional, Elissalde, C., additional, Estournès, C., additional, Garay, J.E., additional, Grasso, S., additional, Gucci, F., additional, Higuchi, M., additional, Huez, J., additional, Jaworska, L., additional, Klimczyk, P., additional, Kodera, Y., additional, Kubota, M., additional, Kus, U., additional, Largeteau, A., additional, Mahot, P., additional, Manière, C., additional, Mphahlele, M.R., additional, Munir, Z.A., additional, Murakami, M., additional, Muralidhar, M., additional, Naimi, F., additional, Noudem, J., additional, Ohyanagi, M., additional, Olevsky, E.A., additional, Olubambi, P.A., additional, Orrù, R., additional, Prakasam, M., additional, Reece, M., additional, Retoux, R., additional, Rua-Taborda, M.-I., additional, Saunders, T., additional, Tyrpek, V., additional, Volodchenkov, A.D., additional, and Weibel, A., additional
- Published
- 2019
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45. Enhanced mechanical properties of pure titanium based on solid-state reactions during a combination of mechanical milling and spark plasma sintering process
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Kubota, M., primary
- Published
- 2019
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46. Effect of Si and Al additions to carbon steel on material transfer and coating damage mechanism in turning with CVD coated tools
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Aiso, T., Wiklund, U., Kubota, M., and Jacobson, S.
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- 2016
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47. Assessment of effects of differences in trunk posture during Fowler’s position on hemodynamics and cardiovascular regulation in older and younger subjects
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Kubota S, Endo Y, Kubota M, and Shigemasa T
- Subjects
aging ,cardiovascular regulation ,hemodynamics ,Fowler's position ,Geriatrics ,RC952-954.6 - Abstract
Satoshi Kubota,1 Yutaka Endo,1 Mitsue Kubota,1 Tomohiko Shigemasa2 1School of Nursing and Rehabilitation Sciences at Odawara, International University of Health and Welfare, Odawara, Kanagawa, Japan; 2Department of Cardiology, International University of Health and Welfare Atami Hospital, Atami, Shizuoka, Japan Background: Downward shifts in blood volume with changing position generally cause tachycardic responses. Age-related decreases in vagal nerve activity could contribute to orthostatic hypotension in older individuals. Fowler’s position is a reclined position with the back between 30° and 60°, used to facilitate breathing, eating, and other routine daily activities in frail and elderly patients. Objective: This study examined whether stroke volume (SV) was higher and heart rate (HR) lower in Fowler’s position with an upright upper trunk than in Fowler’s position with the whole trunk upright in both older and younger subjects, based on the assumption that lower HR would result from reduced sympathetic activation in older individuals. Methods: We assessed hemodynamics and HR variability from electrocardiography, noninvasive arterial pressure and impedance cardiography in 11 younger male subjects (age range, 20–22 years) and 11 older male subjects (age range, 64–79 years), using three positions: supine, or Fowler’s positions with either 30° of lower trunk inclination and 60° of upper trunk inclination (UT60) or 60° of whole trunk inclination (WT60). Comparisons were then made between age groups and between positions. Results: Reductions in SV and tachycardic response were smaller with UT60 than with WT60, in both younger and older subjects. In addition, reduced tachycardic response with upright upper trunk appeared attributable to decreased vagal withdrawal in younger subjects and to reduced sympathetic activation in older subjects. Conclusion: Our findings indicate that an upright upper trunk during Fowler’s position allowed maintenance of SV and inhibited tachycardic response compared to an upright whole trunk regardless of age, although the autonomic mechanisms underlying tachycardic responses differed between younger and older adults. An upright upper trunk in Fowler’s position might help to reduce orthostatic stress and facilitate routine activities and conversation in frail patients. Keywords: aging, cardiovascular regulation, hemodynamics, Fowler’s position, stroke volume
- Published
- 2017
48. Medial Plica Increases Risk For Progression Of Medial Meniscus Extrusion And Osteophyte Development In Middle-Aged Populations With Kellgren-Lawrence Classification Grade 0 -Data From Osteoarthritis Initiative (Oai)
- Author
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HADA, S., primary, KANEKO, H., additional, ADILI, A., additional, LIU, L., additional, TOMURA, J., additional, WAKANA, S., additional, SHIOZAWA, J., additional, KIM, Y., additional, KOBAYASHI, K., additional, KUBOTA, M., additional, and ISHIJIMA, M., additional
- Published
- 2023
- Full Text
- View/download PDF
49. Open Wedgehigh Tibial Osteotomy (Owhto)Contributespost-Operativegood Clinical Results For Patients With Knee Osteoarthritis Up To Grade 3 Of Kellgren-Lawrence Classification
- Author
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Kubota, M., primary, Kaneko, H., additional, Kim, Y., additional, Yoshida, K., additional, Kobayashi, K., additional, Tomura, J., additional, Wakana, S., additional, Shiozawa, J., additional, Hada, S., additional, Saita, Y., additional, and Ishijima, M., additional
- Published
- 2023
- Full Text
- View/download PDF
50. Enlargement Of Medial Meniscal Extrusion Increases A Risk For Incidence Of Early Stage Knee Osteoarthritis -Six-Year Longitudinal Study Using Data From Osteoarthritis Initiative (Oai)
- Author
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KOBAYASHI, K., primary, KANEKO, H., additional, AOKI, T., additional, ADILI, A., additional, LIU, L., additional, NEGISHI, Y., additional, TOMURA, J., additional, WAKANA, S., additional, SHIOZAWA, J., additional, KIM, Y., additional, HADA, S., additional, KUBOTA, M., additional, and ISHIJIMA, M., additional
- Published
- 2023
- Full Text
- View/download PDF
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