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861 results on '"Kubota, Koji"'

21. Laparoscopic median arcuate ligament release using an anterior approach for median arcuate ligament syndrome.

Author

Kubota, Koji, Shimizu, Akira, Notake, Tsuyoshi, Nakamura, Satoshi, and Soejima, Yuji

Subjects
CELIAC artery, SOFT tissue injuries, LIGAMENTS, ABDOMINAL pain, SYMPTOMS
Abstract

Median arcuate ligament syndrome (MALS) is a rare condition characterized by nonspecific symptoms, such as abdominal pain, nausea, and vomiting. Furthermore, the development and rupture of pancreaticoduodenal artery aneurysms pose a potentially fatal risk. Median arcuate ligament release (MALR) is useful in the treatment of MALS, with most procedures performed laparoscopically. However, detailed descriptions of laparoscopic MALR (lap‐MALR) procedures are rare. In this study, we performed lap‐MALR via an anterior approach with dissection of the right lateral wall of the celiac artery (CA). For optimal visualization of the right side of the CA, the right branch of the inferior phrenic artery was divided. We believe that this procedure allows the MAL to be released within a sufficient surgical field and without excess or deficiency. Here, we present the details of six patients who underwent lap‐MALR for varying indications; three for pancreaticoduodenal artery aneurysms due to CA obstruction (unruptured, n = 1; ruptured, n = 2), two cases prior to hepato‐biliary‐pancreatic surgery, and one symptomatic case. In all cases, lap‐MALR was performed as described above, and the CA stenosis was successfully released. Our case series demonstrates the safety and reliability of our lap‐MALR procedure in the treatment of MALS‐related disorders, including pancreaticoduodenal artery aneurysms associated with CA compression. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Combination of advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score as a promising marker for surgical procedure selection for hepatocellular carcinoma.

Author

Hosoda, Kiyotaka, Shimizu, Akira, Kubota, Koji, Notake, Tsuyoshi, Kitagawa, Noriyuki, Yoshizawa, Takahiro, Sakai, Hiroki, Hayashi, Hikaru, Yasukawa, Koya, and Soejima, Yuji

Subjects
SURGICAL complications, HEPATIC fibrosis, NON-alcoholic fatty liver disease, LUNG cancer, PNEUMONIA, LIVER surgery
Abstract

Aim: Methods of predicting severe postoperative complications after anatomical resection for hepatocellular carcinoma are yet to be established. We aimed to clarify the relationship between inflammation‐based prognostic scores and liver fibrosis markers and the incidence of postoperative complications after anatomical resection for hepatocellular carcinoma as well as the usefulness of these markers in surgical procedure selection. Methods: We included 374 patients with hepatocellular carcinoma who had undergone initial hepatectomy between January 2007 and December 2021. The association between inflammation‐based prognostic scores or liver fibrosis markers and postoperative complications was evaluated, and severe postoperative complication rates in the high‐risk group defined by these markers were compared in terms of surgical procedure. Results: The advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score correlated significantly with severe postoperative complications after anatomical resection, with areas under the curve of 0.67 and 0.61, respectively. The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score resulted in a larger area under the curve (0.69). Furthermore, in the high‐risk group determined by the combined score, the anatomical resection group had a significantly higher incidence of severe complications than the partial resection group (P < 0.01). There were no significant differences in prognosis among the surgical procedures in the high‐risk group. Conclusion: The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score serves as a predictive marker for severe postoperative complications after anatomical resection. This combined marker may contribute to appropriate surgical procedure selection. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Enantioselective Synthesis of N,S‐Acetals by an Oxidative Pummerer‐Type Transformation using Phase‐Transfer Catalysis

Author

Biswas, Souvagya, Kubota, Koji, Orlandi, Manuel, Turberg, Mathias, Miles, Dillon H, Sigman, Matthew S, and Toste, F Dean

Subjects
Acetals, Catalysis, Cyclization, Oxidation-Reduction, Phase Transition, Stereoisomerism, Substrate Specificity, Sulfides, Sulfur, acetals, chiral anions, organocatalysis, phase-transfer catalysis, sulfur, Chemical Sciences, Organic Chemistry
Abstract

Reported is the first enantioselective oxidative Pummerer-type transformation using phase-transfer catalysis to deliver enantioenriched sulfur-bearing heterocycles. This reaction includes the direct oxidation of sulfides to a thionium intermediate, followed by an asymmetric intramolecular nucleophilic addition to form chiral cyclic N,S-acetals with moderate to high enantioselectivites. Deuterium-labelling experiments were performed to identify the stereodiscrimination step of this process. Further analysis of the reaction transition states, by means of multidimensional correlations and DFT calculations, highlight the existence of a set of weak noncovalent interactions between the catalyst and substrate that govern the enantioselectivity of the reaction.

Published
2018

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