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197 results on '"Kuang,Yuting"'

12. Controlled siRNA Release of Nanopolyplex for Effective Targeted Anticancer Therapy in Animal Model

Author

Jia,Jingchao, Yang,Jing, Qian,Leimin, Zhou,Biao, Tang,Xiaodong, Liu,Shuanghai, Wu,Li, Chen,Jifeng, Kuang,Yuting, Jia,Jingchao, Yang,Jing, Qian,Leimin, Zhou,Biao, Tang,Xiaodong, Liu,Shuanghai, Wu,Li, Chen,Jifeng, and Kuang,Yuting

Abstract

Jingchao Jia,1,2,* Jing Yang,3,* Leimin Qian,2 Biao Zhou,2 Xiaodong Tang,2 Shuanghai Liu,2 Li Wu,4 Jifeng Chen,5 Yuting Kuang1 1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of General Surgery, Jiangyin Hospital Affiliated to Nantong University, Wuxi, People’s Republic of China; 3Jiangnan University Medical Center, Wuxi, People’s Republic of China; 4Department of Pharmaceutics, People’s Hospital of Shanggao, Yichun, People’s Republic of China; 5The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, Jinan University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuting Kuang, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China, Email yuting_kuang@163.com Jifeng Chen, The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, Jinan University, Guangzhou, People’s Republic of China, Email chenjifeng-1987@163.comIntroduction: Spatiotemporally controlled release of siRNA for anti-tumor therapy poses significant challenges. Near-infrared (NIR) light, known for its exceptional tissue penetration and minimal tissue invasiveness, holds promise as a viable exogenous stimulus for inducing controlled siRNA release in vivo. However, the majority of light-responsive chemical bonds exhibit absorption wavelengths in the ultraviolet (UV) or short-wavelength visible light range.Methods: To achieve NIR-controlled siRNA release, the study synthesized a UV-sensitive triblock copolymer cRGD-poly(ethylene glycol)-b-poly(aspartic acid ester-5-(2’-(dimethylamino)ethoxy)-2-nitrobenzyl alcohol)-b-polyphenylalanine, abbreviated as cRGD-PEG-PAsp(EDONB)-PPHE. This copolymer is composed of a cRGD-capped PEG block (cRGD-PEG), a poly(aspartate) block modified with cationic moieties throu

Published
2024

28. The Coexpression and Clinical Significance of Costimulatory Molecules B7-H1, B7-H3, and B7-H4 in Human Pancreatic Cancer [Retraction]

Author

Chen,Yan, Sun,Jing, Zhao,Hua, Zhu,Dongming, Zhi,Qiaoming, Song,Shiduo, Zhang,Lifeng, He,Songbing, Kuang,Yuting, Zhang,Zixiang, Li,Dechun, Chen,Yan, Sun,Jing, Zhao,Hua, Zhu,Dongming, Zhi,Qiaoming, Song,Shiduo, Zhang,Lifeng, He,Songbing, Kuang,Yuting, Zhang,Zixiang, and Li,Dechun

Abstract

Chen Y, Sun J, Zhao H, et al. Onco Targets Ther. 2014;7:1465–1472. The Editor and Publisher of OncoTargets and Therapy wish to retract the published article. Concerns were raised regarding the alleged duplication of features in Figure 1A. Specifically, panel B7-H1 and B7-H4, row A, Cancer tissue, appears to show duplicated regions. The authors did not respond to our queries regarding the alleged duplication, nor did they provide original data for their study. The Editor requested to retract the article and the authors were notified of this. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”. This retraction relates to this paper

Published
2022

32. THE COMPARATIVE EFFICACY OF INCLISIRAN, PCSK9 INHIBITING MONOCLONAL ANTIBODIES, AND EZETIMIBE FOR THE TREATMENT OF HIGH CHOLESTEROL IN ADULTS WITH OR AT RISK OF ASCVD: A SYSTEMATIC LITERATURE REVIEW AND NETWORK META-ANALYSIS

Author

Campbell, Caresse, primary, Desai, Nihar R., additional, Electricwala, Batul, additional, Stoekenbroek, Robert, additional, Kuang, Yuting, additional, Nevo, Arianna, additional, Chang, Hsiu-Ching, additional, Uyei, Jennifer, additional, and Cristino, Joaquim, additional

Published
2022
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37. A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice

Author

Cheng, Chieh-Fang, Sahu, Divya, Tsen, Fred, Zhao, Zhengwei, Fan, Jianhua, Kim, Rosie, Wang, Xinyi, O'Brien, Kathryn, Li, Yong, Kuang, Yuting, Chen, Mei, Woodley, David T., and Li, Wei

Subjects
Diagnosis, Care and treatment, Research, Properties, Diabetes mellitus -- Diagnosis -- Care and treatment, Growth factors -- Properties, Wound healing -- Research, Cell migration -- Research, Diabetes -- Diagnosis -- Care and treatment
Abstract

Wounds that fail to heal in a timely manner, for example, diabetic foot ulcers, pose a health, economic, and social problem worldwide. For decades, conventional wisdom has pointed to growth [...]

Published
2011
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45. Comparative Efficacy of Dual and Single Initiation of Add-On Oral Antihyperglycemic Agents in Type 2 Diabetes Uncontrolled on Metformin Alone: A Systematic Literature Review and Network Meta-Analysis

Author

Lautsch, Dominik, primary, Alsumali, Adnan, additional, McLeod, Euan, additional, Kuang, Yuting, additional, He, Jing, additional, Singh, Rajpal, additional, Nevo, Arianna, additional, Arnet, Urs, additional, Uyei, Jennifer, additional, and Rajpathak, Swapnil, additional

Published
2020
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50. Prognostic significance of LINC00460 overexpression in solid tumours: a meta-analysis.

Author

Chen Dai, Yan Zhang, Hao Ni, Yuting Kuang, Zhihua Xu, Dai, Chen, Zhang, Yan, Ni, Hao, Kuang, Yuting, and Xu, Zhihua

Subjects
TUMORS, CANCER, NON-small-cell lung carcinoma, RNA metabolism, META-analysis, ANTHROPOMETRY, AGE distribution, METASTASIS, PROGNOSIS, SEX distribution, TUMOR classification
Abstract

The prognostic value of long intergenic non-protein coding RNA 460 (LINC00460) overexpression in human solid malignant tumours remains unclear. Therefore, we conducted the meta-analysis to systematically review and assess the evidence for the correlation between LINC00460 overexpression and clinicopathological features and overall survival (OS) of patients with solid malignant tumour. An electronic search of PubMed, EMBASE, Web of Science, CNKI, Cochrane Library, Chinese Biological Medical Literature database and WanFang database was applied to select eligible articles. Pooled ORs or HRs with their 95% CIs were calculated to estimate the effects. 9 eligible studies with a total of 935 patients were enrolled in this meta-analysis. The results revealed that high LINC00460 expression was associated with positive lymph node metastasis (positive vs negative: OR=2.97, 95% CI 1.74 to 5.05, p=0.812), advanced tumour-node-metastasis stage (III+IV vs I+II: OR=2.82, 95% CI 1.64 to 4.85, p=0.193) and poorer differentiation (high vs low: OR=0.60, 95% CI 0.36 to 0.99, p=0.569). Additionally, the overexpression of LINC00460 could predict a poorer OS (HR=1.57, 95% CI 1.39 to 1.77) and the shorter disease-free survival (HR=2.32, 95% CI 1.25 to 4.31). Furthermore, according to subgroup analysis and meta-regression results, the heterogeneity of current meta-analysis may be attributed to the differences of cancer type and follow-up months. High expression of LINC00460 could predict poor prognosis in patients with solid malignant tumour. LINC00460 may serve as potential prognostic biomarker for clinical outcomes in various human solid malignant tumours. [ABSTRACT FROM AUTHOR]

Published
2020
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