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4 results on '"Kuang, Qihong"'

2. MSC-Based Cell Therapy in Neurological Diseases: A Concise Review of the Literature in Pre-Clinical and Clinical Research.

Author

Zhang, Xiaorui, Kuang, Qihong, Xu, Jianguang, Lin, Qing, Chi, Haoming, and Yu, Daojin

Subjects
*LITERATURE reviews, *NEUROLOGICAL disorders, *MEDICAL research, *CELLULAR therapy, *MESENCHYMAL stem cells
Abstract

Mesenchymal stem cells (MSCs) are multipotent stromal cells with the ability to self-renew and multi-directional differentiation potential. Exogenously administered MSCs can migrate to damaged tissue sites and participate in the repair of damaged tissues. A large number of pre-clinical studies and clinical trials have demonstrated that MSCs have the potential to treat the abnormalities of congenital nervous system and neurodegenerative diseases. Therefore, MSCs hold great promise in the treatment of neurological diseases. Here, we summarize and highlight current progress in the understanding of the underlying mechanisms and strategies of MSC application in neurological diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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4. R93P Substitution in the PmrB HAMP Domain Contributes to Colistin Heteroresistance in Escherichia coliIsolates from Swine

Author

Kuang, Qihong, He, Dandan, Sun, Huarun, Hu, Huihui, Li, Fulin, Li, Wenya, Hu, Gongzheng, Wu, Hua, and Yuan, Li

Abstract

Here, the mechanisms of colistin heteroresistance (CHR) were assessed in 12 Escherichia coliisolates from swine in China. CHR was investigated by population analysis profile tests. CHR stability was studied by culturing isolates for five overnight incubation periods in colistin-free medium. Subsequently, the mcr-1gene and mutations in PmrAB, PhoPQ, and MgrB were screened in parental isolates and resistant subpopulations. Additionally, the expression levels of phoPQ, its target gene pagP, and its negative regulator gene mgrB, as well as pmrABand its target genes pmrHFIJKLMand pmrC, were determined by real-time relative quantitative PCR.

Published
2020
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