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18 results on '"Ksouri, Habib"'

1. P1585: PLATELET TRANSFUSION INCREMENT IN THE SETTING OF HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: A SINGLE-CENTER PROSPECTIVE STUDY

Author

Belloumi, Dorra, primary, Amany, Selmi, additional, Yaiche, Insaf Ben, additional, Rihab, Ouerghi, additional, Ksouri, Habib, additional, Chambi, Emna, additional, Slama, Sonia, additional, Gzara, Asma, additional, Torjemane, Lamia, additional, Joudi, Kalthoum, additional, Mekni, Sabrine, additional, Adejlil, Nour Ben, additional, Turki, Ines, additional, Manel, Chaabane, additional, Ladeb, Saloua, additional, Hmida, Slama, additional, and Othman, Tarek Ben, additional

Published
2023
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3. Single autologous stem-cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial

Author

Abdelkefi, Abderrahman, Ladeb, Saloua, Torjman, Lamia, Othman, Tarek Ben, Lakhal, Amel, Romdhane, Neila Ben, Omri, Halima El, Elloumi, Moez, Belaaj, Hatem, Jeddi, Ramzi, Aissaouï, Lamia, Ksouri, Habib, Hassen, Assia Ben, Msadek, Fahmi, Saad, Ali, Hsaïri, Mohamed, Boukef, Kamel, Amouri, Ahlem, Louzir, Hechmi, Dellagi, Koussay, and Abdeladhim, Abdeladhim Ben

Published
2008
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12. Time of onset, viral load, relapse, and duration of active cytomegalovirus infection in bone marrow transplant outcomes

Author

Ksouri, Habib, Torjman, Lamia, Lakhal, Amel, Abdelkefi, Abdelrahmen, Ladeb, Saloua, Eljed, Hana, Slim, Amine, Zouari, Bechir, Ben Othmen, Tarek, and Ben Hassen, Assia

Subjects
Adult, Male, Time Factors, Adolescent, Age Factors, Graft vs Host Disease, Middle Aged, Viral Load, Prognosis, Hematologic Diseases, Treatment Outcome, Child, Preschool, Cytomegalovirus Infections, Humans, Transplantation, Homologous, Female, Child, Bone Marrow Transplantation, Retrospective Studies
Abstract

Active cytomegalovirus infection remains a major problem for bone marrow transplant recipients. If not quickly diagnosed and treated, it can evolve into cytomegalovirus disease, which represents a life-threatening complication. In this work, we sought to evaluate the interactions between clinical complications after bone marrow transplant and factors associated with active cytomegalovirus infection.We evaluated 91 allogeneic bone marrow transplant recipients (35 female, 56 male; median age, 20 years; age range, 3-47 years) for malignant and nonmalignant hematologic diseases. Active cytomegalovirus infection was monitored using pp65 cytomegalovirus antigenemia and a semiquantitative cytomegalovirus polymerase chain reaction. Cytomegalovirus end-organ disease was defined as an association between compatible signs and symptoms (dyspnea, hypoxia, and diarrhea) and detection of cytomegalovirus (or= 2,000 cytomegalovirus genome copies/mL) by hybrid capture assay in tissue biopsy. Variables were compared using the chi-square and Fisher exact tests. Time of death after bone marrow transplant was plotted using the Kaplan-Meier method. A Cox regression model was used for multivariate survival analysis with 95% confidence limits.Sixty-four patients experienced active cytomegalovirus infection, 26 had acute graft-versus-host disease, and 11 had cytomegalovirus diseases. The overall survival rate at 4 years was 83.52%. On multivariate analyses, cytomegalovirus disease (hazard ratio = 15.9, P = .001) and age older than 18 years (hazard ratio = 8, P = .18) were the only independent negative prognostic factors for overall survival. Occurrence of acute graft-versus-host disease was increased by early active cytomegalovirus infection (P = .03) and represents a significant factor for active cytomegalovirus infection recurrence (P = .01). Viral load as quantified by antigenemia and cytomegalovirus DNA in the patients' peripheral blood leukocytes was significantly associated with clinical complications.Active cytomegalovirus infection interacts significantly in several ways with graft-versus-host disease and others infections. Acute graft-versus-host disease increases the chances of a poor outcome, especially of acquiring cytomegalovirus disease. Cytomegalovirus disease constitutes a significant independent risk factor for death after bone marrow transplant.

Published
2008

17. Switch from beta-thalassemia major to beta-thalassemia intermedia after secondary graft failure.

Author

Mellouli F, Ksouri H, Lakhal A, Torjmen L, Abdelkefi A, Ladeb S, Hmida S, Othman TB, and Béjaoui M

Subjects
Child, Family, Female, Fetal Hemoglobin metabolism, Graft Rejection blood, Graft Rejection genetics, Graft Rejection immunology, HLA Antigens immunology, Hemoglobin A metabolism, Hemoglobin A2 metabolism, Histocompatibility Testing, Humans, Polymerase Chain Reaction, Time Factors, Transplantation Conditioning, Transplantation, Homologous, Treatment Outcome, beta-Thalassemia blood, beta-Thalassemia genetics, beta-Thalassemia immunology, Bone Marrow Transplantation adverse effects, Graft Rejection etiology, Transplantation Chimera genetics, beta-Thalassemia surgery
Abstract

In this article, we report a switch of beta-thalassemia major to intermedia beta-thalassemia after allogeneic bone marrow transplant of a 6-year-old girl from her HLA-matched brother. After stable mixed chimerism, the patient had a secondary graft rejection and returned to total recipient chimerism as assessed by real-time polymerase chain reaction assay. Nonetheless, with a medium hemoglobin rate of 89 g/L, she did not need further transfusions for 60 months after rejection. We conclude that complete loss of donor cells after bone marrow transplant for beta-thalassemia major is compatible with a stable clinical state, probably due to a gamma-globin gene demethylation that enhances gamma-globin chain production and further allows constitution of a fetal hemoglobin rate compatible with free transfusion survival.

Published
2010

18. [Recurrent pregnancy loss related to immune disorders].

Author

Ksouri H, Zitouni M, Achour W, Makni S, and Ben Hassen A

Subjects
Antibody Formation, Female, Humans, Immunity, Cellular, Pregnancy, Abortion, Habitual immunology, Immune System Diseases complications
Abstract

Progress in immunologic methods and diagnostic assays over the last two decades has led the description of an association between some cases of recurrent fetal loss and recurrent spontaneous abortion of unknown cause to immunological factors. Some causal immunological diseases or dysregulations have been identified in pregnant women. These abnormalities may precede or be triggered by the pregnancy, or occasionally result from an impairment of the mother's allogeneic response to the fetus. In this article we review the principal immunological factors and abnormalities implicated in recurrent pregnancy loss and focusing on those generally accepted by the majority of authors.

Published
2003

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