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185 results on '"Krzywicka, Katarzyna"'

1. External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis

Author

Klein, Piers, Shu, Liqi, Lindgren, Erik, de Winter, Maria A., Siegler, James E., Simpkins, Alexis N., Omran, Satareh Salehi, Heldner, Mirjam R., de Havenon, Adam, Abdalkader, Mohamad, al Kasab, Sami, Stretz, Christoph, Wu, Teddy Y., Wilson, Duncan, Asad, Syed Daniyal, Almallouhi, Eyad, Frontera, Jennifer, Kuohn, Lindsey, Rothstein, Aaron, Bakradze, Ekaterina, Henninger, Nils, Zubair, Adeel S., Sharma, Richa, Kerrigan, Deborah, Aziz, Yasmin, Mistry, Eva A., van Kammen, Mayte Sanchez, Tatlisumak, Turgut, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Jood, Katarina, Field, Thalia S., Yaghi, Shadi, Coutinho, Jonathan M., and Nguyen, Thanh N.

Published
2024
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3. Reducing the global burden of cerebral venous thrombosis: An international research agenda

Author

Coutinho, Jonathan M, primary, van de Munckhof, Anita, additional, Aguiar de Sousa, Diana, additional, Poli, Sven, additional, Aaron, Sanjith, additional, Arauz, Antonio, additional, Conforto, Adriana B, additional, Krzywicka, Katarzyna, additional, Hiltunen, Sini, additional, Lindgren, Erik, additional, Sánchez van Kammen, Mayte, additional, Shu, Liqi, additional, Bakchoul, Tamam, additional, Belder, Rosalie, additional, van den Berg, René, additional, Boumans, Elisheva, additional, Cannegieter, Suzanne, additional, Cano-Nigenda, Vanessa, additional, Field, Thalia S, additional, Fragata, Isabel, additional, Heldner, Mirjam R, additional, Hernández-Pérez, María, additional, Klok, Frederikus A, additional, Leker, Ronen R, additional, Lucas-Neto, Lia, additional, Molad, Jeremy, additional, Nguyen, Thanh N, additional, Saaltink, Dirk-Jan, additional, Saposnik, Gustavo, additional, Sharma, Pankaj, additional, Stam, Jan, additional, Thijs, Vincent, additional, van der Vaart, Michiel, additional, Werring, David J, additional, Wong Ramos, Diana, additional, Yaghi, Shadi, additional, Yeşilot, Nilüfer, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Jood, Katarina, additional, Arnold, Marcel, additional, and Ferro, José M, additional

Published
2024
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4. Neuro-Psychological Outcome of ICU-Admitted COVID-19 Patients Presenting With CNS Complications

Author

Pelle, Juliette, Nedelec, Thomas, Marois, Clémence, Delorme, Cecile, Corvol, Jean-Christophe, Delattre, Jean-Yves, Carvalho, Stephanie, Sagnes, Sandrine, Dubois, Bruno, Navarro, Vincent, Louapre, Celine, Stojkovic, Tanya, Idbaih, Ahmed, Rosso, Charlotte, Grabli, David, Gales, Ana Zenovia, Millet, Bruno, Rohaut, Benjamin, Bayen, Eleonore, Dupont, Sophie, Bruneteau, Gaelle, Lehericy, Stephane, Seilhean, Danielle, Durr, Alexandra, Lamari, Foudil, Houot, Marion, Brochard, Vanessa Batista, Lubetzki, Catherine, Seilhean, Danielle, Pradat-Diehl, Pascale, Rosso, Charlotte, Hoang-Xuan, Khe, Fontaine, Bertrand, Naccache, Lionel, Fossati, Philippe, Arnulf, Isabelle, Durr, Alexandra, Carpentier, Alexandre, Edel, Yves, Robain, Gilberte, Thoumie, Philippe, Degos, Bertrand, Sharshar, Tarek, Alamowitch, Sonia, Apartis-Bourdieu, Emmanuelle, Peretti, Charles-Siegried, Ursu, Renata, Dzierzynski, Nathalie, Bourron, Kiyoka Kinugawa, Belmin, Joel, Oquendo, Bruno, Pautas, Eric, Verny, Marc, Samson, Yves, Leder, Sara, Leger, Anne, Deltour, Sandrine, Baronnet, Flore, Bombois, Stephanie, Touat, Mehdi, Idbaih, Ahmed, Sanson, Marc, Dehais, Caroline, Houillier, Caroline, Laigle-Donadey, Florence, Psimaras, Dimitri, Alenton, Agusti, Younan, Nadia, Villain, Nicolas, Grabli, David, del Mar Amador, Maria, Bruneteau, Gaelle, Louapre, Celine, Mariani, Louise-Laure, Mezouar, Nicolas, Mangone, Graziella, Meneret, Aurelie, Hartmann, Andreas, Tarrano, Clement, Bendetowicz, David, Pradat, Pierre-François, Baulac, Michel, Sambin, Sara, Pichit, Phintip, Chochon, Florence, Hesters, Adele, Herlin, Bastien, Nguyen, An Hung, Procher, Valerie, Demoule, Alexandre, Morawiec, Elise, Mayaux, Julien, Faure, Morgan, Ewenczyk, Claire, Coarelli, Giulia, Heinzmann, Anna, Stojkovic, Tanya, Masingue, Marion, Bassez, Guillaume, Navarro, Vincent, An, Isabelle, Worbe, Yulia, Lambrecq, Virginie, Debs, Rabab, Musat, Esteban Munoz, Lenglet, Timothee, Lambrecq, Virginie, Hanin, Aurelie, Chougar, Lydia, Shor, Nathalia, Pyatigorskaya, Nadya, Galanaud, Damien, Leclercq, Delphine, Demeret, Sophie, Rohaut, Benjamin, Cao, Albert, Marois, Clemence, Weiss, Nicolas, Gassama, Salimata, Guennec, Loic Le, Degos, Vincent, Jacquens, Alice, Similowski, Thomas, Morelot-Panzini, Capucine, Rotge, Jean-Yves, Saudreau, Bertrand, Millet, Bruno, Pitron, Victor, Sarni, Nassim, Girault, Nathalie, Maatoug, Redwan, Leu, Smaranda, Bayen, Eleonore, Thivard, Lionel, Mokhtari, Karima, Plu, Isabelle, Gonçalves, Bruno, Bottin, Laure, Yger, Marion, Ouvrard, Gaelle, Haddad, Rebecca, Ketz, Flora, Lafuente, Carmelo, Oasi, Christel, Megabarne, Bruno, Herve, Dominique, Salman, Haysam, Rametti-Lacroux, Armelle, Chalançon, Alize, Herve, Anais, Royer, Hugo, Beauzor, Florence, Maheo, Valentine, Laganot, Christelle, Minelli, Camille, Fekete, Aurelie, Grine, Abel, Biet, Marie, Hilab, Rania, Besnard, Aurore, Bouguerra, Meriem, Goudard, Gwen, Houairi, Saida, Al-Youssef, Saba, Pires, Christine, Oukhedouma, Anissa, Siuda-Krzywicka, Katarzyna, Malkinson, Tal Seidel, Agguini, Hanane, Said, Safia, and Houot, Marion

Published
2023
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5. Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19.

Author

Scutelnic, Adrian, van de Munckhof, Anita, Miraclin, Angel T., Aaron, Sanjith, Hameed, Sajid, Wasay, Mohammad, Grosu, Oxana, Krzywicka, Katarzyna, Sánchez van Kammen, Mayte, Lindgren, Erik, Moreira, Tiago, Acampora, Roberto, Negro, Alberto, Karapanayiotides, Theodoros, Yaghi, Shadi, Revert, Anna, Cuadrado Godia, Elisa, Garcia-Madrona, Sebastian, La Spina, Paolino, and Grillo, Francesco

Published
2024
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7. Abstract TP180: Characteristics and Outcomes of Cerebral Venous Sinus Thrombosis Associated With COVID-19

Author

Scutelnic, Adrian, primary, van de Munckhof, Anita, additional, Miaclin, Angel, additional, AARON, SANJITH, additional, Hameed, Sajid, additional, Wasay, Muhammad, additional, Grosu, Oxana, additional, Krzywicka, Katarzyna, additional, Sanchez van Kammen, Mayte, additional, Lindgren, Erik, additional, Hom Moreira, Tiago, additional, Acampora, Roberto, additional, Alberto, Negro, additional, KARAPANAYIOTIDES, Theodoros, additional, Marialuisa, Zedde, additional, Yaghi, Shadi, additional, Ana, Barbera, additional, Cuadrado Godia, Elisa, additional, La Spina, Paolo, additional, Francesco, Grillo, additional, GIamello, Fabrizio, additional, Nguyen, Thanh, additional, Abdalkader, Mohamad, additional, Alina, Buture, additional, raposo, Nicolas, additional, Tsivogoulis, Georgios, additional, Candelaresi, Paolo, additional, Kristoffersen, Espen Saxhaug, additional, Ciacciarelli, Antonio, additional, Mbroh, Joshua, additional, Katheryna, Antonenko, additional, Kremer Hovinga, Johanna A., additional, Batenkova, Tatjana, additional, Scoppettuolo, Pasquale, additional, Jood, Katarina, additional, Aguiar De Sousa, Diana, additional, Poli, Sven, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Coutinho, Jonathan M, additional, Ferro, Jose, additional, Arnold, Marcel, additional, and Heldner, Mirjam, additional

Published
2024
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8. Abstract TMP108: External Validation of the SI 2 NCAL 2 C Score for Mortality Following Cerebral Venous Thrombosis

Author

Klein, Piers, primary, Shu, Liqi, additional, Lindgren, Erik, additional, de Winter, Maria A, additional, Siegler, James E, additional, Simpkins, Alexis N, additional, Salehi Omran, Setareh, additional, Heldner, Mirjam, additional, de Havenon, Adam H, additional, Abdalkader, Mohamad, additional, Al Kasab, Sami, additional, Stretz, Christoph, additional, Wu, Teddy, additional, Wilson, Duncan, additional, Asad, Syed Daniyal, additional, Almallouhi, Eyad, additional, Frontera, Jennifer, additional, Kuohn, Lindsey, additional, Rothstein, Aaron, additional, Bakradze, Ekaterina, additional, Henninger, Nils, additional, Zubair, Adeel S, additional, Sharma, Richa, additional, Kerrigan, Deborah, additional, Aziz, Yasmin, additional, Mistry, Eva, additional, Sanchez van Kammen, Mayte, additional, Tatlisumak, Turgut, additional, Krzywicka, Katarzyna, additional, Aguiar De Sousa, Diana, additional, Jood, Katarina, additional, Field, Thalia S, additional, Yaghi, Shadi, additional, Coutinho, Jonathan M, additional, and Nguyen, Thanh N, additional

Published
2024
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9. Outcomes of Cerebral Venous Thrombosis due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase

Author

van de Munckhof, Anita, Lindgren, Erik, Kleinig, Timothy J., Field, Thalia S., Cordonnier, Charlotte, Krzywicka, Katarzyna, Poli, Sven, Sánchez van Kammen, Mayte, Borhani-Haghighi, Afshin, Lemmens, Robin, Scutelnic, Adrian, Ciccone, Alfonso, Gattringer, Thomas, Wittstock, Matthias, Dizonno, Vanessa, Devroye, Annemie, Elkady, Ahmed, Günther, Albrecht, Cervera, Alvaro, Mengel, Annerose, Chew, Beng Lim Alvin, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Jacobi, Christian, Soriano, Cristina, Michalski, Dominik, Zamani, Zohreh, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Vuillier, Fabrice, Bode, Felix J., Caparros, François, Maier, Frank, Tsivgoulis, Georgios, Katzberg, Hans D., Duan, Jiangang, Burrow, Jim, Pelz, Johann, Mbroh, Joshua, Oen, Joyce, Schouten, Judith, Zimmermann, Julian, Ng, Karl, Garambois, Katia, Petruzzellis, Marco, Carvalho Dias, Mariana, Ghiasian, Masoud, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Skjelland, Mona, Almasi-Dooghaee, Mostafa, Cuisenier, Pauline, Murphy, Seán, Timsit, Serge, Coutts, Shelagh B., Schönenberger, Silvia, Nagel, Simon, Hiltunen, Sini, Chatterton, Sophie, Cox, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Mirzaasgari, Zahra, Middeldorp, Saskia, Levi, Marcel M., Kremer Hovinga, Johanna A., Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, Aguiar de Sousa, Diana, Ferro, José M., and Coutinho, Jonathan M.

Published
2022
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12. Endovascular treatment of cerebral sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia.

Author

Weller, Johannes, Krzywicka, Katarzyna, van de Munckhof, Anita, Dorn, Franziska, Althaus, Katharina, Bode, Felix J, Bandettini di Poggio, Monica, Buck, Brian, Kleinig, Timothy, Cordonnier, Charlotte, Dizonno, Vanessa, Duan, Jiangang, Elkady, Ahmed, Chew, Beng Lim Alvin, Garcia-Esperon, Carlos, Field, Thalia S, Legault, Catherine, Morin Martin, Mar, Michalski, Dominik, and Pelz, Johann

Published
2024
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13. ABO blood group associated with cerebral venous thrombosis after Oxford-AstraZeneca COVID-19 vaccination: a case–control study.

Author

Ken-Dror, Gie, Sharma, Pankaj, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Ghoreishi, Abdoreza, Borhani-Haghighi, Afshin, Negro, Alberto, Günther, Albrecht, Cervera, Alvaro, Tuladhar, Anil Man, Devroye, Annemie, Mengel, Annerose, Aujayeb, Avinash, Casolla, Barbara, Chew, Beng Lim Alvin, Zanferrari, Carla, Garcia-Esperon, Carlos, Wahl, Christoph M., and Alonso, Daniel Guisado

Abstract

Objectives: To determine whether blood group influences development of cerebral venous thrombosis (CVT) after administration of the coronavirus disease 2019 (COVID-19) AstraZeneca ChAdOx1-S vaccine. Design: A case–control study. Univariate and multivariate logistic regression was used to determine the association between blood type and COVID-19 vaccination status. Setting: Vaccinated and unvaccinated patients recruited from the international Bio-Repository to Establish the Aetiology of Sinovenous Thrombosis study and the Cerebral Venous Sinus Thrombosis With Thrombocytopenia Syndrome Study Group. Participants: All patients were of European descent and age and sex matched. Cases (n = 82) were patients ≥18 years old who suffered a CVT within 28 days of a first dose of ChAdOx1-S vaccine. Controls (n = 441) were unvaccinated CVT patients ≥18 years old. All patients were of European descent. Main outcome measures: Frequency of blood type and ABO allele distribution by vaccination status. Results: Blood group O was found to be more prevalent among CVT patients with vaccine-induced thrombotic thrombocytopenia (VITT-CVT) after ChAdOx1-S vaccination compared with unvaccinated CVT cases (43% vs. 17%, respectively, p < 0.001). Blood group A was less prevalent, though still high, in the vaccinated group compared with the unvaccinated group (47% vs. 71%, respectively, p < 0.001). No significant differences were observed in the VITT-CVT non-ChAdOx1-S vaccine group and unvaccinated pre-COVID-19 CVT group for blood group. Conclusions: Blood group O is more prevalent among patients with VITT-CVT after ChAdOx1-S vaccination compared with unvaccinated cases, independent of well-established CVT risk factors. A larger dataset may be able to determine whether those of blood groups B and/or AB may be safely vaccinated with the low cost, readily available and easily transported ChAdOx1-S rather than adopting a complete ban. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Endovascular treatment of cerebral sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia

Author

Weller, Johannes, primary, Krzywicka, Katarzyna, additional, van de Munckhof, Anita, additional, Dorn, Franziska, additional, Althaus, Katharina, additional, Bode, Felix J, additional, Bandettini di Poggio, Monica, additional, Buck, Brian, additional, Kleinig, Timothy, additional, Cordonnier, Charlotte, additional, Dizonno, Vanessa, additional, Duan, Jiangang, additional, Elkady, Ahmed, additional, Chew, Beng Lim Alvin, additional, Garcia-Esperon, Carlos, additional, Field, Thalia S, additional, Legault, Catherine, additional, Morin Martin, Mar, additional, Michalski, Dominik, additional, Pelz, Johann, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Petruzzellis, Marco, additional, Raposo, Nicolas, additional, Skjelland, Mona, additional, Zimatore, Domenico Sergio, additional, Aaron, Sanjith, additional, Sanchez van Kammen, Mayte, additional, Aguiar de Sousa, Diana, additional, Lindgren, Erik, additional, Jood, Katarina, additional, Scutelnic, Adrian, additional, Heldner, Mirjam R, additional, Poli, Sven, additional, Arauz, Antonio, additional, Conforto, Adriana B, additional, Putaala, Jukka, additional, Tatlisumak, Turgut, additional, Arnold, Marcel, additional, Coutinho, Jonathan M, additional, Günther, Albrecht, additional, Zimmermann, Julian, additional, and Ferro, José M, additional

Published
2023
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15. Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study

Author

van de Munckhof, Anita, primary, Sánchez van Kammen, Mayte, additional, Krzywicka, Katarzyna, additional, Aaron, Sanjith, additional, Aguiar de Sousa, Diana, additional, Antochi, Florina, additional, Arauz, Antonio, additional, Barboza, Miguel A., additional, Conforto, Adriana B., additional, Dentali, Francesco, additional, Galdames Contreras, Daniel, additional, Ji, Xunming, additional, Jood, Katarina, additional, Heldner, Mirjam R., additional, Hernández-Pérez, María, additional, Kam, Wayneho, additional, Kleinig, Timothy J., additional, Kristoffersen, Espen S., additional, Leker, Ronen R., additional, Lemmens, Robin, additional, Poli, Sven, additional, Yeşilot, Nilüfer, additional, Wasay, Mohammad, additional, Wu, Teddy Y., additional, Arnold, Marcel, additional, Lucas-Neto, Lia, additional, Middeldorp, Saskia, additional, Putaala, Jukka, additional, Tatlisumak, Turgut, additional, Ferro, José M., additional, and Coutinho, Jonathan M., additional

Published
2023
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16. When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants

Author

Chrobak, Adrian Andrzej, primary, Siuda-Krzywicka, Katarzyna, additional, Soltys, Zbigniew, additional, Bielak, Sylwia, additional, Nowaczek, Dominik, additional, Żyrkowska, Aleksandra, additional, Fafrowicz, Magdalena, additional, Marek, Tadeusz, additional, Pęcherzewska, Ewa, additional, Kużdżał, Jan, additional, Starowicz-Filip, Anna, additional, Gorostowicz, Aleksandra, additional, Dudek, Dominika, additional, and Siwek, Marcin, additional

Published
2023
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17. Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19

Author

Scutelnic, Adrian, primary, van de Munckhof, Anita, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Lindgren, Erik, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Middeldorp, Saskia, additional, Aaron, Sanjith, additional, Borhani-Haghighi, Afshin, additional, Arauz, Antonio, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Putaala, Jukka, additional, Wasay, Mohammad, additional, Conforto, Adriana Bastos, additional, de Sousa, Diana Aguiar, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Arnold, Marcel, additional, Heldner, Mirjam R, additional, Antonenko, Kateryna, additional, Mbroh, Joshua, additional, Brodard, Justine, additional, Hooshmandi, Etrat, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J., additional, Skjelland, Mona, additional, Duan, Jiangang, additional, Hiltunen, Sini, additional, Zuurbier, Susanna M., additional, Petruzzellis, Marco, additional, Sharma, Aarti R., additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Puthuppallil, Anemon, additional, Tuladhar, Anil M., additional, Mengel, Annerose, additional, Medina, Antonio, additional, Hellström Vogel, Åslög, additional, Tawa, Audrey, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Lim Alvin Chew, Beng, additional, Ziaadini, Bentalhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Zanferrari, Carla, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Legault, Catherine, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Pelz, Johann, additional, Wahl, Christoph, additional, Kern, Rolf, additional, Tracol, Clement, additional, Soriano, Cristina, additional, Guisado-Alonso, Daniel, additional, Bougon, David, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, De Maistre, Emmanuel, additional, Saxhaug Kristoffersen, Espen, additional, Bonneville, Fabrice, additional, Geeraerts, Thomas, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Grillo, Francesco, additional, Caparros, François, additional, Susen, Sophie, additional, Maier, Frank, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Frisullo, Giovanni, additional, Franchineau, Guillaume, additional, Cangür, Hakan, additional, Katzberg, Hans, additional, Mozhdehipanah, Hossein, additional, Sibon, Igor, additional, Baharoglu, M. Irem, additional, Masjuan, Jaime, additional, Brar, Jaskiran, additional, Payen, Jean-Francois, additional, Burrow, Jim, additional, Fernandes, João, additional, Octavio López Esparza, Jorge, additional, Oen, Joyce, additional, Schouten, Judith, additional, Ng, Karl, additional, Chatterton, Sophie, additional, Wronski, Miriam, additional, Althaus, Katharina, additional, Garambois, Katia, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Humbertjean, Lisa, additional, Lebrato Hernandez, Lucia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Dubois, Marie-Cecile, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Kumar Karunakaran, Ravi, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Scholz, Moritz J., additional, Kahnis, Robert, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R., additional, Kumar Paramasivan, Naveen, additional, Erat Sreedharan, Sapna, additional, Sylaja, PN, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Cuisenier, Pauline, additional, Huet, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Nemati, Reza, additional, Vieira, Ricardo, additional, Goh, Rudy, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S., additional, Bal, Simerpreet, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Cox, Thomas, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Shaygannejad, Vahid, additional, Garcia-Talavera, Veronica, additional, Palma, Vincenzo, additional, Arslan, Yıldız, additional, Mirzaasgari, Zahra, additional, Yavari, Zeinab, additional, Zamani, Zohreh, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, and van Gorp, Eric C.M., additional

Published
2023
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19. Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries

Author

van de Munckhof, Anita, primary, Borhani-Haghighi, Afshin, additional, Aaron, Sanjith, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Scutelnic, Adrian, additional, Lindgren, Erik, additional, Duan, Jiangang, additional, Arslan, Yıldız, additional, van Gorp, Eric CM, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Heldner, Mirjam R, additional, Arnold, Marcel, additional, de Sousa, Diana Aguiar, additional, Wasay, Mohammad, additional, Arauz, Antonio, additional, Conforto, Adriana Bastos, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Mbroh, Joshua, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J, additional, Skjelland, Mona, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Hiltunen, Sini, additional, Petruzzellis, Marco, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, Middeldorp, Saskia, additional, Sharma, Aarti R, additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Tuladhar, Anil M, additional, Mengel, Annerose, additional, Medina, Antonio, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Spratt, Neil, additional, Ziaadini, Bentolhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, Maistre, Emmanuel De, additional, Saxhaug Kristoffersen, Espen, additional, Hooshmandi, Etrat, additional, Bonneville, Fabrice, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Katzberg, Hans, additional, Sibon, Igor, additional, Baharoglu, Irem, additional, Masjuan, Jaime, additional, Fernandes, João, additional, Pelz, Johann, additional, Octavio López Esparza, Jorge, additional, Schouten, Judith, additional, Ng, Karl, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Wronski, Miriam, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R, additional, Kumar Paramasivan, Naveen, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Sylaja, PN, additional, Kumar Karunakaran, Ravi, additional, Vieira, Ricardo, additional, Kern, Rolf, additional, Goh, Rudy, additional, Erat Sreedharan, Sapna, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Palma, Vincenzo, additional, Mirzaasgari, Zahra, additional, Zamani, Zohreh, additional, Mirahmadizadeh, Alireza, additional, Gutierrez-Romero, Alonso, additional, Iván Valdes-Ferrer, Ivan, additional, Elizabeth Ceballos-Liceaga, Santa, additional, and Maria Santibañez-Copado, Ana, additional

Published
2023
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23. Decompressive surgery in cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia

Author

Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Cordonnier, Charlotte, Bode, Felix J, Field, Thalia S, Michalski, Dominik, Pelz, Johann, Skjelland, Mona, Wiedmann, Markus, Zimmermann, Julian, Wittstock, Matthias, Zanotti, Bruno, Ciccone, Alfonso, Bandettini di Poggio, Monica, Borhani-Haghighi, Afshin, Chatterton, Sophie, Aujayeb, Avinash, Devroye, Annemie, Dizonno, Vanessa, Geeraerts, Thomas, Giammello, Fabrizio, Günther, Albrecht, Ichaporia, Nasli R, Kleinig, Timothy, Kristoffersen, Espen S, Lemmens, Robin, De Maistre, Emmanuel, Mirzaasgari, Zahra, Payen, Jean-Francois, Putaala, Jukka, Petruzzellis, Marco, Raposo, Nicolas, Sadeghi-Hokmabadi, Elyar, Schoenenberger, Silvia, Umaiorubahan, Meenakshisundaram, Sylaja, P N, van de Munckhof, Anita, Sánchez van Kammen, Mayte, Lindgren, Erik, Jood, Katarina, Scutelnic, Adrian, Heldner, Mirjam R, Poli, Sven, Kruip, Marieke J H A, Arauz, Antonio, Conforto, Adriana B, Aaron, Sanjith, Middeldorp, Saskia, Tatlisumak, Turgut, Arnold, Marcel, Coutinho, Jonathan M, Ferro, José M, HUS Neurocenter, Clinicum, Department of Neurosciences, Neurologian yksikkö, Repositório da Universidade de Lisboa, Hematology, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Neurology, ANS - Neurovascular Disorders, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ARD - Amsterdam Reproduction and Development

Subjects
Brain death, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 3112 Neurosciences, cerebral venous thrombosis, coma, 3124 Neurology and psychiatry, surgery, COVID-19 vaccinations, All institutes and research themes of the Radboud University Medical Center, Neurology, SDG 3 - Good Health and Well-being, Cerebral venous thrombosis, brain death, Surgery, Neurology (clinical), Coma, 610 Medicine & health
Abstract

© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made., Background and purpose: Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is an adverse drug reaction occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. CVST-VITT patients often present with large intracerebral haemorrhages and a high proportion undergoes decompressive surgery. Clinical characteristics, therapeutic management and outcomes of CVST-VITT patients who underwent decompressive surgery are described and predictors of in-hospital mortality in these patients are explored. Methods: Data from an ongoing international registry of patients who developed CVST within 28 days of SARS-CoV-2 vaccination, reported between 29 March 2021 and 10 May 2022, were used. Definite, probable and possible VITT cases, as defined by Pavord et al. (N Engl J Med 2021; 385: 1680-1689), were included. Results: Decompressive surgery was performed in 34/128 (27%) patients with CVST-VITT. In-hospital mortality was 22/34 (65%) in the surgical and 27/94 (29%) in the non-surgical group (p < 0.001). In all surgical cases, the cause of death was brain herniation. The highest mortality rates were found amongst patients with preoperative coma (17/18, 94% vs. 4/14, 29% in the non-comatose; p < 0.001) and bilaterally absent pupillary reflexes (7/7, 100% vs. 6/9, 67% with unilaterally reactive pupil, and 4/11, 36% with bilaterally reactive pupils; p = 0.023). Postoperative imaging revealed worsening of index haemorrhagic lesion in 19 (70%) patients and new haemorrhagic lesions in 16 (59%) patients. At a median follow-up of 6 months, 8/10 of surgical CVST-VITT who survived admission were functionally independent. Conclusions: Almost two-thirds of surgical CVST-VITT patients died during hospital admission. Preoperative coma and bilateral absence of pupillary responses were associated with higher mortality rates. Survivors often achieved functional independence., This research was funded by the Netherlands Organization for Health Research and Development (ZonMw, grant number 10430072110005) and the Dr C.J. Vaillant Foundation.

Published
2023

24. sj-docx-1-wso-10.1177_17474930231182901 – Supplemental material for Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries

Author

van de Munckhof, Anita, Borhani-Haghighi, Afshin, Aaron, Sanjith, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Cordonnier, Charlotte, Kleinig, Timothy J, Field, Thalia S, Poli, Sven, Lemmens, Robin, Scutelnic, Adrian, Lindgren, Erik, Duan, Jiangang, Arslan, Yıldız, van Gorp, Eric CM, Kremer Hovinga, Johanna A, Günther, Albrecht, Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R, Arnold, Marcel, de Sousa, Diana Aguiar, Wasay, Mohammad, Arauz, Antonio, Conforto, Adriana Bastos, Ferro, José M, and Coutinho, Jonathan M

Subjects
Neurology and Neuromuscular Diseases, FOS: Clinical medicine, Cardiology, Medicine
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930231182901 for Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries by Anita van de Munckhof, Afshin Borhani-Haghighi, Sanjith Aaron, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Charlotte Cordonnier, Timothy J Kleinig, Thalia S Field, Sven Poli, Robin Lemmens, Adrian Scutelnic, Erik Lindgren, Jiangang Duan, Yıldız Arslan, Eric CM van Gorp, Johanna A Kremer Hovinga, Albrecht Günther, Katarina Jood, Turgut Tatlisumak, Jukka Putaala, Mirjam R Heldner, Marcel Arnold, Diana Aguiar de Sousa, Mohammad Wasay, Antonio Arauz, Adriana Bastos Conforto, José M Ferro and Jonathan M Coutinho in International Journal of Stroke

Published
2023
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25. Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19

Author

Scutelnic, Adrian, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Lindgren, Erik, Cordonnier, Charlotte, Kleinig, Timothy J, Field, Thalia S, Poli, Sven, Lemmens, Robin, Middeldorp, Saskia, Aaron, Sanjith, Borhani-Haghighi, Afshin, Arauz, Antonio, Kremer Hovinga, Johanna A, Günther, Albrecht, Putaala, Jukka, Wasay, Mohammad, Conforto, Adriana Bastos, de Sousa, Diana Aguiar, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M, Coutinho, Jonathan M, Arnold, Marcel, and Heldner, Mirjam R

Subjects
610 Medicine & health
Abstract

INTRODUCTION Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. PATIENTS AND METHODS We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. RESULTS Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28-54) vs 45 (28-56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28-79) vs 68 (30-125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19-62) vs 53 (20-92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. DISCUSSION AND CONCLUSIONS Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.

Published
2023
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26. sj-docx-1-eso-10.1177_23969873231185213 – Supplemental material for Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID- 19

Author

Scutelnic, Adrian, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Lindgren, Erik, Cordonnier, Charlotte, Kleinig, Timothy J, Field, Thalia S, Poli, Sven, Lemmens, Robin, Middeldorp, Saskia, Aaron, Sanjith, Borhani-Haghighi, Afshin, Arauz, Antonio, Kremer Hovinga, Johanna A, Günther, Albrecht, Putaala, Jukka, Wasay, Mohammad, Conforto, Adriana Bastos, de Sousa, Diana Aguiar, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M, Coutinho, Jonathan M, Arnold, Marcel, and Heldner, Mirjam R

Subjects
Neurology and Neuromuscular Diseases, FOS: Clinical medicine, Cardiology, Medicine
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873231185213 for Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19 by Adrian Scutelnic, Anita van de Munckhof, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Charlotte Cordonnier, Timothy J Kleinig, Thalia S Field, Sven Poli, Robin Lemmens, Saskia Middeldorp, Sanjith Aaron, Afshin Borhani-Haghighi, Antonio Arauz, Johanna A Kremer Hovinga, Albrecht Günther, Jukka Putaala, Mohammad Wasay, Adriana Bastos Conforto, Diana Aguiar de Sousa, Katarina Jood, Turgut Tatlisumak, José M Ferro, Jonathan M Coutinho, Marcel Arnold, Mirjam R Heldner

Published
2023
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27. A scoring tool to predict mortality and dependency after cerebral venous thrombosis.

Author

Lindgren, Erik, Krzywicka, Katarzyna, de Winter, Maria A., Sánchez Van Kammen, Mayte, Heldner, Mirjam R., Hiltunen, Sini, Aguiar de Sousa, Diana, Mansour, Maryam, Canhão, Patrícia, Ekizoğlu, Esme, Rodrigues, Miguel, Martins Silva, Elisa, Garcia‐Esperon, Carlos, Arnao, Valentina, Aridon, Paolo, Simaan, Naaem Moin, Silvis, Suzanne M., Zuurbier, Susanna M., Scutelnic, Adrian, and Sezgin, Mine

Subjects
*CEREBRAL embolism & thrombosis, *VENOUS thrombosis, *CEREBRAL hemorrhage, *BRAIN death, CENTRAL nervous system infections
Abstract

Background and purpose: A prognostic score was developed to predict dependency and death after cerebral venous thrombosis (CVT) to identify patients for targeted therapy in future clinical trials. Methods: Data from the International CVT Consortium were used. Patients with pre‐existent functional dependency were excluded. Logistic regression was used to predict poor outcome (modified Rankin Scale score 3–6) at 6 months and Cox regression to predict 30‐day and 1‐year all‐cause mortality. Potential predictors derived from previous studies were selected with backward stepwise selection. Coefficients were shrunk using ridge regression to adjust for optimism in internal validation. Results: Of 1454 patients with CVT, the cumulative number of deaths was 44 (3%) and 70 (5%) for 30 days and 1 year, respectively. Of 1126 patients evaluated regarding functional outcome, 137 (12%) were dependent or dead at 6 months. From the retained predictors for both models, the SI2NCAL2C score was derived utilizing the following components: absence of female‐sex‐specific risk factor, intracerebral hemorrhage, infection of the central nervous system, neurological focal deficits, coma, age, lower level of hemoglobin (g/l), higher level of glucose (mmol/l) at admission, and cancer. C‐statistics were 0.80 (95% confidence interval [CI] 0.75–0.84), 0.84 (95% CI 0.80–0.88) and 0.84 (95% CI 0.80–0.88) for the poor outcome, 30‐day and 1‐year mortality model, respectively. Calibration plots indicated a good model fit between predicted and observed values. The SI2NCAL2C score calculator is freely available at www.cerebralvenousthrombosis.com. Conclusions: The SI2NCAL2C score shows adequate performance for estimating individual risk of mortality and dependency after CVT but external validation of the score is warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Management of Cerebral Venous Thrombosis Due to Adenoviral COVID‐19 Vaccination

Author

Scutelnic, Adrian, primary, Krzywicka, Katarzyna, additional, Mbroh, Joshua, additional, van de Munckhof, Anita, additional, van Kammen, Mayte Sánchez, additional, de Sousa, Diana Aguiar, additional, Lindgren, Erik, additional, Jood, Katarina, additional, Günther, Albrecht, additional, Hiltunen, Sini, additional, Putaala, Jukka, additional, Tiede, Andreas, additional, Maier, Frank, additional, Kern, Rolf, additional, Bartsch, Thorsten, additional, Althaus, Katharina, additional, Ciccone, Alfonso, additional, Wiedmann, Markus, additional, Skjelland, Mona, additional, Medina, Antonio, additional, Cuadrado‐Godia, Elisa, additional, Cox, Thomas, additional, Aujayeb, Avinash, additional, Raposo, Nicolas, additional, Garambois, Katia, additional, Payen, Jean‐Francois, additional, Vuillier, Fabrice, additional, Franchineau, Guillaume, additional, Timsit, Serge, additional, Bougon, David, additional, Dubois, Marie‐Cécile, additional, Tawa, Audrey, additional, Tracol, Clement, additional, De Maistre, Emmanuel, additional, Bonneville, Fabrice, additional, Vayne, Caroline, additional, Mengel, Annerose, additional, Michalski, Dominik, additional, Pelz, Johann, additional, Wittstock, Matthias, additional, Bode, Felix, additional, Zimmermann, Julian, additional, Schouten, Judith, additional, Buture, Alina, additional, Murphy, Sean, additional, Palma, Vincenzo, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Nagel, Simon, additional, Schoenenberger, Silvia, additional, Frisullo, Giovanni, additional, Zanferrari, Carla, additional, Grillo, Francesco, additional, Giammello, Fabrizio, additional, Martin, Mar Morin, additional, Cervera, Alvaro, additional, Burrow, Jim, additional, Esperon, Carlos Garcia, additional, Chew, Beng Lim Alvin, additional, Kleinig, Timothy J., additional, Soriano, Cristina, additional, Zimatore, Domenico S., additional, Petruzzellis, Marco, additional, Elkady, Ahmed, additional, Miranda, Miguel S., additional, Fernandes, João, additional, Vogel, Åslög Hellström, additional, Johansson, Elias, additional, Philip, Anemon Puthuppallil, additional, Coutts, Shelagh B., additional, Bal, Simerpreet, additional, Buck, Brian, additional, Legault, Catherine, additional, Blacquiere, Dylan, additional, Katzberg, Hans D., additional, Field, Thalia S., additional, Dizonno, Vanessa, additional, Gattringer, Thomas, additional, Jacobi, Christian, additional, Devroye, Annemie, additional, Lemmens, Robin, additional, Kristoffersen, Espen Saxhaug, additional, di Poggio, Monica Bandettini, additional, Ghiasian, Masoud, additional, Karapanayiotides, Theodoros, additional, Chatterton, Sophie, additional, Wronski, Miriam, additional, Ng, Karl, additional, Kahnis, Robert, additional, Geeraerts, Thomas, additional, Reiner, Peggy, additional, Cordonnier, Charlotte, additional, Middeldorp, Saskia, additional, Levi, Marcel, additional, van Gorp, Eric C. M., additional, van de Beek, Diederik, additional, Brodard, Justine, additional, Kremer Hovinga, Johanna A., additional, Kruip, Marieke J. H. A., additional, Tatlisumak, Turgut, additional, Ferro, José M., additional, Coutinho, Jonathan M., additional, Arnold, Marcel, additional, Poli, Sven, additional, and Heldner, Mirjam R., additional

Published
2022
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32. Cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after a second ChAdOx1 nCoV-19 dose

Author

Krzywicka, Katarzyna, primary, van de Munckhof, Anita, additional, Zimmermann, Julian, additional, Bode, Felix J., additional, Frisullo, Giovanni, additional, Karapanayiotides, Theodoros, additional, Pötzsch, Bernd, additional, Sánchez van Kammen, Mayte, additional, Heldner, Mirjam R., additional, Arnold, Marcel, additional, Kremer Hovinga, Johanna A., additional, Ferro, José M., additional, Aguiar de Sousa, Diana, additional, and Coutinho, Jonathan M., additional

Published
2022
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34. Abstract 51: Age Stratified Risk Of Cerebral Venous Sinus Thrombosis After Sars-Cov-2 Vaccination

Author

Krzywicka, Katarzyna, primary, van de Munckhof, Anita, additional, Sanchez van Kammen, Mayte, additional, Heldner, Mirjam R, additional, Jood, Katarina, additional, Lindgren, Erik, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Kremer Hovinga, Johanna A., additional, Middeldorp, Saskia, additional, Levi, Marcel M, additional, Cordonnier, Charlotte, additional, Arnold, Marcel, additional, Zwinderman, Aeilko H, additional, Ferro, Jose M, additional, Coutinho, Jonathan M, additional, and Aguiar de Sousa, Diana, additional

Published
2022
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36. The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre

Author

Delorme, Cécile, Houot, Marion, Rosso, Charlotte, Carvalho, Stéphanie, Nedelec, Thomas, Maatoug, Redwan, Pitron, Victor, Gassama, Salimata, Sambin, Sara, Bombois, Stéphanie, Herlin, Bastien, Ouvrard, Gaëlle, Bruneteau, Gaëlle, Hesters, Adèle, Gales, Ana Zenovia, Millet, Bruno, Lamari, Foudil, Lehericy, Stéphane, Navarro, Vincent, Rohaut, Benjamin, Demeret, Sophie, Maisonobe, Thierry, Yger, Marion, Degos, Bertrand, Mariani, Louise-Laure, Bouche, Christophe, Dzierzynski, Nathalie, Oquendo, Bruno, Ketz, Flora, Nguyen, An-Hung, Kas, Aurélie, Lubetzki, Catherine, Delattre, Jean-Yves, Corvol, Jean-Christophe, Fontaine, Bertrand, Thoumie, Philippe, Sharshar, Tarek, Alamowitch, Sonia, Apartis-Bourdieu, Emmanuelle, Peretti, Charles-Siegried, Ursu, Renata, Bourron, Kiyoka Kinugawa, Belmin, Joel, Pautas, Eric, Verny, Marc, Samson, Yves, Leder, Sara, Leger, Anne, Deltour, Sandrine, Baronnet, Flore, Touat, Mehdi, Sanson, Marc, Dehais, Caroline, Houillier, Caroline, Laigle-Donadey, Florence, Psimaras, Dimitri, Alenton, Agusti, Younan, Nadia, Villain, Nicolas, Del Mar Amador, Maria, Mezouar, Nicolas, Mangone, Graziella, Meneret, Aurelie, Hartmann, Andreas, Tarrano, Clement, Bendetowicz, David, Pradat, Pierre-François, Baulac, Michel, Pichit, Phintip, Chochon, Florence, Nguyen, An Hung, Porcher, Valerie, Demoule, Alexandre, Morawiec, Elise, Mayaux, Julien, Faure, Morgan, Ewenczyk, Claire, Coarelli, Giulia, Heinzmann, Anna, Masingue, Marion, Bassez, Guillaume, An, Isabelle, Worbe, Yulia, Lambrecq, Virginie, Debs, Rabab, Musat, Esteban Munoz, Lenglet, Timothee, Hanin, Aurelie, Chougar, Lydia, Shor, Nathalia, Pyatigorskaya, Nadya, Galanaud, Damien, Leclercq, Delphine, Cao, Albert, Marois, Clemence, Weiss, Nicolas, Le Guennec, Loic, Degos, Vincent, Jacquens, Alice, Similowski, Thomas, Morelot-Panzini, Capucine, Rotge, Jean-Yves, Saudreau, Bertrand, Sarni, Nassim, Girault, Nathalie, Leu, Smaranda, Thivard, Lionel, Mokhtari, Karima, Plu, Isabelle, Gonçalves, Bruno, Bottin, Laure, Haddad, Rebecca, Lafuente, Carmelo, Oasi, Christel, Megabarne, Bruno, Herve, Dominique, Salman, Haysam, Rametti-Lacroux, Armelle, Chalançon, Alize, Herve, Anais, Royer, Hugo, Beauzor, Florence, Maheo, Valentine, Laganot, Christelle, Minelli, Camille, Fekete, Aurelie, Grine, Abel, Biet, Marie, Hilab, Rania, Besnard, Aurore, Bouguerra, Meriem, Goudard, Gwen, Houairi, Saida, Al-Youssef, Saba, Pires, Christine, Oukhedouma, Anissa, Siuda-Krzywicka, Katarzyna, Malkinson, Tal Seidel, Agguini, Hanane, Said, Safia, Gales, Ana, Brochard, Vanessa, Bourron, Kiyoka, Nguyen, An, Musat, Esteban, Malkinson, Tal, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de psychiatrie adulte [CHU Pitié-Salpêtière], CHU Pitié-Salpêtrière [AP-HP], Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Sorbonne Université (SU), Hôpital Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service des Pathologies du sommeil [CHU Pitié-Salpêtrière], Service de Biochimie Métabolique [CHU Pitié-Salpêtrière], Service de Neuroradiologie [CHU Pitié-Salpêtrière], Service de Neurophysiologie [CHU Pitié-Salpêtrière], Service des Soins Intensifs [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Médecine Gériatrique [CHU Pitié-Salpêtrière], Service d'Activités cliniques [CHU Pitié-Salpêtrière], Service de médecine nucléaire [CHU Pitié-Salpétrière], Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Centre de Recherche en Myologie, and Service de gériatrie [CHU Pitié-Salpêtrière]

Subjects
Pediatrics, medicine.medical_specialty, encephalitis, Encephalopathy, Context (language use), law.invention, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, law, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Intensive care, medicine, Critical illness polyneuropathy, Biological Psychiatry, 030304 developmental biology, 0303 health sciences, business.industry, AcademicSubjects/SCI01870, COVID-19, medicine.disease, encephalopathy, Comorbidity, Intensive care unit, 3. Good health, Psychiatry and Mental health, Neurology, Observational study, Original Article, AcademicSubjects/MED00310, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], business, critical illness neuropathy, 030217 neurology & neurosurgery, Encephalitis
Abstract

A variety of neuropsychiatric complications has been described in association with Covid-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with Covid-19 seen in a multidisciplinary hospital center over six months. We conducted a retrospective, observational study on all patients showing neurological or psychiatric symptoms in the context of Covid-19 seen in the medical and university neuroscience department of Assistance Publique Hopitaux de Paris -Sorbonne University. We collected demographic data, comorbidities, symptoms and severity of Covid-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from CSF analysis, MRI, EEG and EMG. A total of 249 Covid-19 patients with a de novo neurological or psychiatric manifestation were included in the database and 245 were included in the final analyses. One-hundred fourteen patients (47%) were admitted to the intensive care unit and 10 (4%) died. The most frequent neuropsychiatric complications diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%), and cerebrovascular disorders (16%). No patients showed CSF evidence of SARS-CoV-2. Encephalopathy was associated with older age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the intensive care unit. The majority of these neuropsychiatric complications could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders., Graphical Abstract Graphical Abstract

Published
2021

37. Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination

Author

Krzywicka, Katarzyna, primary, van de Munckhof, Anita, additional, Sánchez van Kammen, Mayte, additional, Heldner, Mirjam R., additional, Jood, Katarina, additional, Lindgren, Erik, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Kremer Hovinga, Johanna A., additional, Middeldorp, Saskia, additional, Levi, Marcel M., additional, Cordonnier, Charlotte, additional, Arnold, Marcel, additional, Zwinderman, Aeilko H., additional, Ferro, José M., additional, Coutinho, Jonathan M., additional, and Aguiar de Sousa, Diana, additional

Published
2021
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40. Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS‐CoV‐2 vaccination

Author

van de Munckhof, Anita, primary, Krzywicka, Katarzyna, additional, Aguiar de Sousa, Diana, additional, Sánchez van Kammen, Mayte, additional, Heldner, Mirjam R., additional, Jood, Katarina, additional, Lindgren, Erik, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Kremer Hovinga, Johanna A., additional, Middeldorp, Saskia, additional, Levi, Marcel, additional, Arnold, Marcel, additional, Ferro, José M., additional, and Coutinho, Jonathan M., additional

Published
2021
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41. Post‐SARS‐CoV‐2‐vaccination cerebral venous sinus thrombosis: an analysis of cases notified to the European Medicines Agency

Author

Krzywicka, Katarzyna, primary, Heldner, Mirjam R., additional, Sánchez van Kammen, Mayte, additional, van Haaps, Thijs, additional, Hiltunen, Sini, additional, Silvis, Suzanne M., additional, Levi, Marcel, additional, Kremer Hovinga, Johanna A., additional, Jood, Katarina, additional, Lindgren, Erik, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Aguiar de Sousa, Diana, additional, Middeldorp, Saskia, additional, Arnold, Marcel, additional, Coutinho, Jonathan M., additional, and Ferro, José M., additional

Published
2021
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42. Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

Author

Sánchez van Kammen, Mayte, Aguiar de Sousa, Diana, Poli, Sven, Cordonnier, Charlotte, Heldner, Mirjam R., van de Munckhof, Anita, Krzywicka, Katarzyna, van Haaps, Thijs, Ciccone, Alfonso, Middeldorp, Saskia, Levi, Marcel M, Kremer Hovinga, Johanna A., Silvis, Suzanne, Hiltunen, Sini, Mansour, Maryam, Arauz, Antonio, Barboza, Miguel A, Field, Thalia S, Tsivgoulis, Georgios, Nagel, Simon, Lindgren, Erik, Tatlisumak, Turgut, Jood, Katarina, Putaala, Jukka, Ferro, Jose M, Arnold, Marcel, and Coutinho, Jonathan M

Subjects
610 Medicine & health
Abstract

Importance Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson). Objective To describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vaccination with and without TTS. Design, Setting, and Participants This cohort study used data from an international registry of consecutive patients with CVST within 28 days of SARS-CoV-2 vaccination included between March 29 and June 18, 2021, from 81 hospitals in 19 countries. For reference, data from patients with CVST between 2015 and 2018 were derived from an existing international registry. Clinical characteristics and mortality rate were described for adults with (1) CVST in the setting of SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia, (2) CVST after SARS-CoV-2 vaccination not fulling criteria for TTS, and (3) CVST unrelated to SARS-CoV-2 vaccination. Exposures Patients were classified as having TTS if they had new-onset thrombocytopenia without recent exposure to heparin, in accordance with the Brighton Collaboration interim criteria. Main Outcomes and Measures Clinical characteristics and mortality rate. Results Of 116 patients with postvaccination CVST, 78 (67.2%) had TTS, of whom 76 had been vaccinated with ChAdOx1 nCov-19; 38 (32.8%) had no indication of TTS. The control group included 207 patients with CVST before the COVID-19 pandemic. A total of 63 of 78 (81%), 30 of 38 (79%), and 145 of 207 (70.0%) patients, respectively, were female, and the mean (SD) age was 45 (14), 55 (20), and 42 (16) years, respectively. Concomitant thromboembolism occurred in 25 of 70 patients (36%) in the TTS group, 2 of 35 (6%) in the no TTS group, and 10 of 206 (4.9%) in the control group, and in-hospital mortality rates were 47% (36 of 76; 95% CI, 37-58), 5% (2 of 37; 95% CI, 1-18), and 3.9% (8 of 207; 95% CI, 2.0-7.4), respectively. The mortality rate was 61% (14 of 23) among patients in the TTS group diagnosed before the condition garnered attention in the scientific community and 42% (22 of 53) among patients diagnosed later. Conclusions and Relevance In this cohort study of patients with CVST, a distinct clinical profile and high mortality rate was observed in patients meeting criteria for TTS after SARS-CoV-2 vaccination.

Published
2021
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43. Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

Author

van Kammen, Mayte Sanchez de Sousa, Diana Aguiar Poli, Sven and Cordonnier, Charlotte Heldner, Mirjam R. van de Munckhof, Anita and Krzywicka, Katarzyna van Haaps, Thijs Ciccone, Alfonso and Middeldorp, Saskia Levi, Marcel M. Hovinga, Johanna A. Kremer and Silvis, Suzanne Hiltunen, Sini Mansour, Maryam Arauz, Antonio Barboza, Miguel A. Field, Thalia S. Tsivgoulis, Georgios Nagel, Simon Lindgren, Erik Tatlisumak, Turgut and Jood, Katarina Putaala, Jukka Ferro, Jose M. Arnold, Marcel and Coutinho, Jonathan M. Cerebral Venous Sinus Thrombosis T

Abstract

Importance Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson). Objective To describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vaccination with and without TTS. Design, Setting, and Participants This cohort study used data from an international registry of consecutive patients with CVST within 28 days of SARS-CoV-2 vaccination included between March 29 and June 18, 2021, from 81 hospitals in 19 countries. For reference, data from patients with CVST between 2015 and 2018 were derived from an existing international registry. Clinical characteristics and mortality rate were described for adults with (1) CVST in the setting of SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia, (2) CVST after SARS-CoV-2 vaccination not fulling criteria for TTS, and (3) CVST unrelated to SARS-CoV-2 vaccination. Exposures Patients were classified as having TTS if they had new-onset thrombocytopenia without recent exposure to heparin, in accordance with the Brighton Collaboration interim criteria. Main Outcomes and Measures Clinical characteristics and mortality rate. Results Of 116 patients with postvaccination CVST, 78 (67.2%) had TTS, of whom 76 had been vaccinated with ChAdOx1 nCov-19; 38 (32.8%) had no indication of TTS. The control group included 207 patients with CVST before the COVID-19 pandemic. A total of 63 of 78 (81%), 30 of 38 (79%), and 145 of 207 (70.0%) patients, respectively, were female, and the mean (SD) age was 45 (14), 55 (20), and 42 (16) years, respectively. Concomitant thromboembolism occurred in 25 of 70 patients (36%) in the TTS group, 2 of 35 (6%) in the no TTS group, and 10 of 206 (4.9%) in the control group, and in-hospital mortality rates were 47% (36 of 76; 95% CI, 37-58), 5% (2 of 37; 95% CI, 1-18), and 3.9% (8 of 207; 95% CI, 2.0-7.4), respectively. The mortality rate was 61% (14 of 23) among patients in the TTS group diagnosed before the condition garnered attention in the scientific community and 42% (22 of 53) among patients diagnosed later. Conclusions and Relevance In this cohort study of patients with CVST, a distinct clinical profile and high mortality rate was observed in patients meeting criteria for TTS after SARS-CoV-2 vaccination. Question What are the clinical characteristics and outcomes of patients with cerebral venous sinus thrombosis with thrombocytopenia syndrome after SARS-CoV-2 vaccination? Findings In this cohort study of 116 patients with cerebral venous sinus thrombosis after SARS-CoV-2 vaccination, 78 (67.2%) had thrombosis with thrombocytopenia syndrome. Patients with thrombosis with thrombocytopenia syndrome were frequently comatose at presentation (24%) and often had intracerebral hemorrhage (68%) and concomitant thromboembolism (36%), and 47% died during hospitalization. Meaning Patients with cerebral venous sinus thrombosis after SARS-CoV-2 vaccination who met criteria for thrombosis with thrombocytopenia syndrome had a distinct clinical profile and high mortality rate. This cohort study describes the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis after SARS-CoV-2 vaccination with and without thrombosis with thrombocytopenia syndrome.

Published
2021

48. Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS‐CoV‐2 vaccination.

Author

van de Munckhof, Anita, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Sánchez van Kammen, Mayte, Heldner, Mirjam R., Jood, Katarina, Lindgren, Erik, Tatlisumak, Turgut, Putaala, Jukka, Kremer Hovinga, Johanna A., Middeldorp, Saskia, Levi, Marcel, Arnold, Marcel, Ferro, José M., and Coutinho, Jonathan M.

Subjects
*CRANIAL sinuses, *VENOUS thrombosis, *SARS-CoV-2, *VACCINATION, *THROMBOCYTOPENIA, *SINUS thrombosis
Abstract

Background and purpose: High mortality rates have been reported in patients with cerebral venous sinus thrombosis (CVST) due to vaccine‐induced immune thrombotic thrombocytopenia (VITT) after vaccination with adenoviral vector SARS‐CoV‐2 vaccines. The aim of this study was to evaluate whether the mortality of patients with CVST‐VITT has decreased over time. Methods: The EudraVigilance database of the European Medicines Agency was used to identify cases of CVST with concomitant thrombocytopenia occurring within 28 days of SARS‐CoV‐2 vaccination. Vaccines were grouped based on vaccine type (adenoviral or mRNA). Cases with CVST onset until 28 March were compared to cases after 28 March 2021, which was the day when the first scientific paper on VITT was published. Results: In total, 270 cases of CVST with thrombocytopenia were identified, of which 266 (99%) occurred after adenoviral vector SARS‐CoV‐2 vaccination (ChAdOx1 nCoV‐19, n = 243; Ad26.COV2.S, n = 23). The reported mortality amongst adenoviral cases with onset up to 28 March 2021 was 47/99 (47%, 95% confidence interval 37%–58%) compared to 36/167 (22%, 95% confidence interval 16%–29%) in cases with onset after 28 March (p < 0.001). None of the four cases of CVST with thrombocytopenia occurring after mRNA vaccination died. Conclusion: The reported mortality of CVST with thrombocytopenia after vaccination with adenoviral vector‐based SARS‐CoV‐2 vaccines has significantly decreased over time, which may indicate a beneficial effect of earlier recognition and/or improved treatment on outcome after VITT. [ABSTRACT FROM AUTHOR]

Published
2022
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