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5. The Thousand Faces of Invasive Group A Streptococcal Infections: Update on Epidemiology, Symptoms, and Therapy

Author

Mercadante, Stefania, primary, Ficari, Andrea, additional, Romani, Lorenza, additional, De Luca, Maia, additional, Tripiciano, Costanza, additional, Chiurchiù, Sara, additional, Calo Carducci, Francesca Ippolita, additional, Cursi, Laura, additional, Di Giuseppe, Martina, additional, Krzysztofiak, Andrzej, additional, Bernardi, Stefania, additional, and Lancella, Laura, additional

Published
2024
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7. Italian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children

Author

Krzysztofiak, Andrzej, Chiappini, Elena, Venturini, Elisabetta, Gargiullo, Livia, Roversi, Marco, Montagnani, Carlotta, Bozzola, Elena, Chiurchiu, Sara, Vecchio, Davide, Castagnola, Elio, Tomà, Paolo, Rossolini, Gian Maria, Toniolo, Renato Maria, Esposito, Susanna, Cirillo, Marco, Cardinale, Fabio, Novelli, Andrea, Beltrami, Giovanni, Tagliabue, Claudia, Boero, Silvio, Deriu, Daniele, Bianchini, Sonia, Grandin, Annalisa, Bosis, Samantha, Ciarcià, Martina, Ciofi, Daniele, Tersigni, Chiara, Bortone, Barbara, Trippella, Giulia, Nicolini, Giangiacomo, Lo Vecchio, Andrea, Giannattasio, Antonietta, Musso, Paola, Serrano, Elena, Marchisio, Paola, Donà, Daniele, Garazzino, Silvia, Pierantoni, Luca, Mazzone, Teresa, Bernaschi, Paola, Ferrari, Alessandra, Gattinara, Guido Castelli, Galli, Luisa, and Villani, Alberto

Published
2021
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8. Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment

Author

Galli, Luisa, Venturini, Elisabetta, Bassi, Andrea, Gattinara, Guido Castelli, Chiappini, Elena, Defilippi, Claudio, Diociaiuti, Andrea, Esposito, Susanna, Garazzino, Silvia, Giannattasio, Antonietta, Krzysztofiak, Andrzej, Latorre, Stefano, Lo Vecchio, Andrea, Marchisio, Paola, Montagnani, Carlotta, Nicolini, Giangiacomo, Novelli, Andrea, Rossolini, Gian Maria, Tersigni, Chiara, Villani, Alberto, El Hachem, May, and Neri, Iria

Published
2019
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11. Pediatric COVID-TB: A Clinical Perspective Based on the Analysis of Three Cases

Author

Leone, Fabrizio, primary, Di Giuseppe, Martina, additional, De Luca, Maia, additional, Cursi, Laura, additional, Calo Carducci, Francesca Ippolita, additional, Krzysztofiak, Andrzej, additional, Chiurchiù, Sara, additional, Romani, Lorenza, additional, Russo, Cristina, additional, Lancella, Laura, additional, and Bernardi, Stefania, additional

Published
2023
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12. Neonatal osteomyelitis: an Italian multicentre report of 22 cases and comparison with the inherent literature

Author

Roversi, Marco, Chiappini, Elena, Toniolo, Renato Maria, Cirillo, Marco, Natale, Fabio, Deriu, Daniele, Grandin, Annalisa, Lancella, Laura, Galli, Luisa, Villani, Alberto, and Krzysztofiak, Andrzej

Abstract

Objective: The primary objective of this study is to report and compare our data with the most relevant literature of the past decade about neonatal osteomyelitis. Study design: We retrospectively review the data of 22 subjects aged 35 days or less who were admitted to three different sites in Italy with a radiological diagnosis of osteomyelitis. The inherent literature was searched and reviewed: five studies were considered for comparison with our data. Results: All the neonates, except three (two pre-term and one post-term), were born at term. The male to female ratio was 1.75 (14 males and 8 females). The mean age at presentation was 19.5 days. The most common presenting signs of the infection were local swelling and reduced mobility of the affected segment. The most common sites of infection were the femur, humerus, and tibia. The mean duration of intravenous antibiotic therapy was 29.5 days. In most neonates the diagnosis was prompt and the antibiotic treatment immediate. A low rate of sequelae was reported. All infants survived through follow up. The data from the inherent literature showed a wide variability, probably owing to the setting and the historical period of the different studies. Conclusion: Neonatal osteomyelitis is an alarming yet poorly understood disease. Nonetheless, our report suggests that a quick diagnosis and treatment can be easily achieved, with good outcome on the remarkably plastic structure of neonatal bones.

Published
2024
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15. COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?

Author

Dona', Daniele, Montagnani, Carlotta, Di Chiara, Costanza, Venturini, Elisabetta, Galli, Luisa, Lo Vecchio, Andrea, Denina, Marco, Olivini, Nicole, Bruzzese, Eugenia, Campana, Andrea, Giacchero, Roberta, Salvini, Filippo, Meini, Antonella, Ponzoni, Matteo, Trapani, Sandra, Rossi, Elena, Lombardi, Mary Haywood, Badolato, Raffaele, Pierri, Luca, Pruccoli, Giulia, Rossin, Sara, Colomba, Claudia, Cazzato, Salvatore, Pacati, Ilaria, Nicolini, Giangiacomo, Pierantoni, Luca, Bianchini, Sonia, Krzysztofiak, Andrzej, Garazzino, Silvia, Giaquinto, Carlo, Castelli Gattinara, Guido, On Behalf Of The Italian Sitip-Sip Pediatric Sars-CoV-Infection Study Group, null, Dona', D., Montagnani, C., Di Chiara, C., Venturini, E., Galli, L., Lo Vecchio, A., Denina, M., Olivini, N., Bruzzese, E., Campana, A., Giacchero, R., Salvini, F., Meini, A., Ponzoni, M., Trapani, S., Rossi, E., Lombardi, M. H., Badolato, R., Pierri, L., Pruccoli, G., Rossin, S., Colomba, C., Cazzato, S., Pacati, I., Nicolini, G., Pierantoni, L., Bianchini, S., Krzysztofiak, A., Garazzino, S., Giaquinto, C., Castelli Gattinara, G., Dona', Daniele, Montagnani, Carlotta, Di Chiara, Costanza, Venturini, Elisabetta, Galli, Luisa, Lo Vecchio, Andrea, Denina, Marco, Olivini, Nicole, Bruzzese, Eugenia, Campana, Andrea, Giacchero, Roberta, Salvini, Filippo, Meini, Antonella, Ponzoni, Matteo, Trapani, Sandra, Rossi, Elena, Lombardi, Mary Haywood, Badolato, Raffaele, Pierri, Luca, Pruccoli, Giulia, Rossin, Sara, Colomba, Claudia, Cazzato, Salvatore, Pacati, Ilaria, Nicolini, Giangiacomo, Pierantoni, Luca, Bianchini, Sonia, Krzysztofiak, Andrzej, Garazzino, Silvia, Giaquinto, Carlo, Castelli Gattinara, Guido, and On Behalf Of The Italian Sitip-Sip Pediatric Sars-CoV-Infection Study Group, null

Subjects
Adult, Fever, COVID-19, SARS-CoV-2, infants, neonates, Infant, Newborn, infant, Infectious Diseases, Cough, Virology, Humans, neonate, Child, Human
Abstract

Compared to adults, severe or fatal COVID-19 disease is much less common in children.However, a higher risk for progression has been reported in infants. Different pediatric COVID-19severity scores are reported in the literature. Methods: Subjects under 90 days of age admittedto 35 Italian institutions for COVID-19 were included. The severity of COVID-19 was scored asmild/moderate or severe/critical following the classification reported in the literature by Venturini,Dong, Kanburoglu, and Gale. To assess the diagnostic accuracy of each classification system, westratified all enrolled patients developing a posteriori severity score based on clinical presentation andoutcomes and then compared all different scores analyzed. Results: We included 216 infants below90 days of age. The most common symptom was fever, followed by coryza, poor feeding, cough, andgastrointestinal manifestations. According to Venturini, Dong, Kanburoglu, and Gale’s severity scores,18%, 6%, 4.2%, and 29.6% of infants presented with severe/critical disease, respectively. A correlationanalysis between these four scores and the a posteriori severity score assigned to all enrolled subjects was performed, and a crescent strength of correlation from Gale (R = 0.355, p < 0.001) to Venturini(R = 0.425, p < 0.001), Dong (R = 0.734, p < 0.001), and Kanburoglu (R = 0.859, p < 0.001) was observed.Conclusions: The percentage of infants with severe COVID-19 varies widely according to the scoresystems. A unique clinical score should be designed for neonates and infants with COVID-19.&nbsp

Published
2022
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19. Safety of Monoclonal Antibodies in Children Affected by SARS-CoV-2 Infection

Author

Romani, Lorenza, primary, Calò Carducci, Francesca Ippolita, additional, Chiurchiù, Sara, additional, Cursi, Laura, additional, De Luca, Maia, additional, Di Giuseppe, Martina, additional, Krzysztofiak, Andrzej, additional, Lancella, Laura, additional, Palma, Paolo, additional, Vallesi, Leonardo, additional, Corsetti, Tiziana, additional, Campana, Andrea, additional, Nicastri, Emanuele, additional, Rossi, Paolo, additional, and Bernardi, Stefania, additional

Published
2022
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21. Additional file 1 of Italian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children

Author

Krzysztofiak, Andrzej, Chiappini, Elena, Venturini, Elisabetta, Gargiullo, Livia, Roversi, Marco, Montagnani, Carlotta, Bozzola, Elena, Chiurchiu, Sara, Vecchio, Davide, Castagnola, Elio, Tomà, Paolo, Rossolini, Gian Maria, Toniolo, Renato Maria, Esposito, Susanna, Cirillo, Marco, Cardinale, Fabio, Novelli, Andrea, Beltrami, Giovanni, Tagliabue, Claudia, Boero, Silvio, Deriu, Daniele, Bianchini, Sonia, Grandin, Annalisa, Bosis, Samantha, Ciarcià, Martina, Ciofi, Daniele, Tersigni, Chiara, Bortone, Barbara, Trippella, Giulia, Nicolini, Giangiacomo, Vecchio, Andrea Lo, Giannattasio, Antonietta, Musso, Paola, Serrano, Elena, Marchisio, Paola, Donà, Daniele, Garazzino, Silvia, Pierantoni, Luca, Mazzone, Teresa, Bernaschi, Paola, Ferrari, Alessandra, Gattinara, Guido Castelli, Galli, Luisa, and Villani, Alberto

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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23. Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Bonfante, Francesco, additional, Petrara, Maria Raffaella, additional, Zicari, Sonia, additional, Pascucci, Giuseppe Rubens, additional, Zangari, Paola, additional, De Ioris, Maria Antonietta, additional, Santilli, Veronica, additional, Manno, E.C., additional, Amodio, Donato, additional, Bortolami, Alessio, additional, Pagliari, Matteo, additional, Concato, Carlo, additional, Linardos, Giulia, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Brodin, Petter, additional, Rossi, Paolo, additional, De Rossi, Anita, additional, Palma, Paolo, additional, Bernardi, Stefania, additional, Romani, Lorenza, additional, Pansa, Paola, additional, Chiurchiú, Sara, additional, Finocchi, Andrea, additional, Cancrini, Caterina, additional, Lancella, Laura, additional, Cursi, Laura, additional, De Luca, Maia, additional, Cutrera, Renato, additional, Sessa, Libera, additional, Morrocchi, Elena, additional, Medri, Chiara, additional, Putignani, Lorenza, additional, Calò Carducci, F.I., additional, D’Argenio, Patrizia, additional, Ciofi degli Atti, Marta, additional, D’Amore, Carmen, additional, Piccioni, Livia, additional, Di Giuseppe, Martina, additional, Jenkner, Alessandro, additional, Giancotta, Carmela, additional, and Krzysztofiak, Andrzej, additional

Published
2021
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24. Use of linezolid in infants and children: a retrospective multicentre study of the Italian Society for Paediatric Infectious Diseases

Author

Garazzino, Silvia, Krzysztofiak, Andrzej, Esposito, Susanna, Castagnola, Elio, Plebani, Alessandro, Galli, Luisa, Cellini, Monica, Lipreri, Rita, Scolfaro, Carlo, Bertaina, Chiara, Calitri, Carmelina, Bozzola, Elena, Lancella, Laura, Quondamcarlo, Anna, Bosis, Samantha, Pugni, Lorenza, Losurdo, Giuseppe, Soresina, Annarosa, De Gaudio, Marina, Mariotti, Ilaria, Mancini, Luca, Gabiano, Clara, and Tovo, Pier-Angelo

Published
2011
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25. Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results from an Italian Multicenter Study

Author

Garazzino, Silvia, primary, Lo Vecchio, Andrea, additional, Pierantoni, Luca, additional, Calò Carducci, Francesca, additional, Marchetti, Federico, additional, Meini, Antonella, additional, Castagnola, Elio, additional, Vergine, Gianluca, additional, Donà, Daniele, additional, Bosis, Samantha, additional, Dodi, Icilio, additional, Venturini, Elisabetta, additional, Felici, Enrico, additional, Giacchero, Roberta, additional, Denina, Marco, additional, Pierri, Luca, additional, Nicolini, Giangiacomo, additional, Montagnani, Carlotta, additional, Krzysztofiak, Andrzej, additional, Bianchini, Sonia, additional, Marabotto, Caterina, additional, Tovo, Pier-Angelo, additional, Lanari, Marcello, additional, Villani, Alberto, additional, Castelli Gattinara, Guido, additional, and Group, Italian SITIP-SIP Pediatric Infecti, additional

Published
2020
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26. Treatment of children with COVID-19: update of the Italian Society of Pediatric Infectious Diseases position paper.

Author

Venturini, Elisabetta, Montagnani, Carlotta, Garazzino, Silvia, Donà, Daniele, Pierantoni, Luca, Lo Vecchio, Andrea, Krzysztofiak, Andrzej, Nicolini, Giangiacomo, Bianchini, Sonia, Galli, Luisa, Villani, Alberto, and Gattinara, Guido Castelli

Subjects
METHYLPREDNISOLONE, COVID-19, COMMUNICABLE diseases, DEXAMETHASONE, PEDIATRICS, ANTIVIRAL agents, MONOCLONAL antibodies, SEVERITY of illness index, CONVALESCENT plasma, OXYGEN therapy, PREDNISONE, CHILDREN
Published
2021
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27. Measles Outbreak in a High-Income Country: Are Pediatricians Ready?

Author

Lo Vecchio, Andrea, Montagnani, Carlotta, Krzysztofiak, Andrzej, Valentini, Piero, Rossi, Nadia, Bozzola, Elena, Castelli Gattinara, Guido, Magurano, Fabio, Guarino, Alfredo, Galli, Luisa, Valentini, Piero (ORCID:0000-0001-6095-9510), Lo Vecchio, Andrea, Montagnani, Carlotta, Krzysztofiak, Andrzej, Valentini, Piero, Rossi, Nadia, Bozzola, Elena, Castelli Gattinara, Guido, Magurano, Fabio, Guarino, Alfredo, Galli, Luisa, and Valentini, Piero (ORCID:0000-0001-6095-9510)

Abstract

BACKGROUND: Measles is a highly communicable infection with potentially severe complications. It is rarely reported in high-income countries and the limited awareness and experience of pediatricians may result in misdiagnosis. The present study aimed at investigating physician's ability and timing to reach diagnosis during a recent outbreak in Italy. METHODS: The Italian Society for Pediatric Infectious Diseases conducted a retrospective, multicenter study in children hospitalized for measles between 1 January 2016 and 30 August 2017 in secondary and tertiary care hospitals. The appropriateness of diagnosis at admission, the time to reach clinical diagnosis, and serological confirmation of measles were recorded. RESULTS: At hospital admission, measles was misdiagnosed in 101 (40.5%) of the 249 children (median age, 14.5 months) enrolled. The appropriate diagnosis increased from 30% to 72.5% during the period of observation (P < .001). A greater chance of receiving an appropriate diagnosis was demonstrated in children who reported a contact with measles (odds ratio [OR], 5.2; 95% confidence interval [CI], 3.0-9.2) or in those seen in institutions that managed more cases (OR, 7.39; 95% CI, 3.22-16.9; P = .0001). In contrast, children with underlying chronic conditions had a higher risk of misdiagnosis (appropriate diagnosis OR, 0.19; 95% CI, 0.10-0.33). The mean time from the onset of symptoms to clinical diagnosis was 4.55 ± 2.2 days and to serological confirmation was 7.0 ± 3.4 days. CONCLUSIONS: Measles is frequently misdiagnosed in low-prevalence settings. Specific measures to increase pediatricians' awareness about vaccine-preventable infections need to be implemented.

Published
2019

28. Complications and risk factors for severe outcome in children with measles

Author

Lo Vecchio, Andrea, primary, Krzysztofiak, Andrzej, additional, Montagnani, Carlotta, additional, Valentini, Piero, additional, Rossi, Nadia, additional, Garazzino, Silvia, additional, Raffaldi, Irene, additional, Di Gangi, Maria, additional, Esposito, Susanna, additional, Vecchi, Barbara, additional, Melzi, Maria Luisa, additional, Lanari, Marcello, additional, Zavarise, Giorgio, additional, Bosis, Samantha, additional, Valenzise, Mariella, additional, Cazzato, Salvatore, additional, Sacco, Michele, additional, Govoni, Maria Rita, additional, Mozzo, Elena, additional, Cambriglia, Maria Donata, additional, Bruzzese, Eugenia, additional, Di Camillo, Chiara, additional, Pata, Davide, additional, Graziosi, Alessandro, additional, Sala, Debora, additional, Magurano, Fabio, additional, Villani, Alberto, additional, Guarino, Alfredo, additional, and Galli, Luisa, additional

Published
2019
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32. Complications and risk factors for severe outcome in children with measles.

Author

Lo Vecchio, Andrea, Krzysztofiak, Andrzej, Montagnani, Carlotta, Valentini, Piero, Rossi, Nadia, Garazzino, Silvia, Raffald, Irene, Di Gangi, Maria, Esposito, Susanna, Vecchi, Barbara, Melzi, Maria Luisa, Lanari, Marcello, Zavarise, Giorgio, Bosis, Samantha, Valenzise, Mariella, Cazzato, Salvatore, Sacco, Michele, Govoni, Maria Rita, Mozzo, Elena, and Cambriglia, Maria Donata

Subjects
MEASLES, VIRAL encephalitis, MEDICAL sciences
Abstract

Objective and Design: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.Results: Nineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95% CI 0.52 to 0.82). CRP values >2 mg/dL were related to higher risk of complications (OR 2.0, 95% CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95% CI 1.43 to 11.8, p<0.01).Conclusion: The risk of severe outcome in measles is independent of age and underlying conditions, but is related to the development of organ complications and may be predicted by CRP value. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Measles Outbreak in a High-Income Country: Are Pediatricians Ready?

Author

Vecchio, Andrea Lo, Montagnani, Carlotta, Krzysztofiak, Andrzej, Valentini, Piero, Rossi, Nadia, Bozzola, Elena, Gattinara, Guido Castelli, Magurano, Fabio, Guarino, Alfredo, Galli, Luisa, and Group, Italian Society for Pediatric Infectious Diseases Measles Study

Subjects
CLINICAL competence, DIAGNOSTIC errors, DISEASE outbreaks, MEASLES, MEDICAL cooperation, PROFESSIONS, RESEARCH, TIME, NATIONAL competency-based educational tests, RETROSPECTIVE studies
Abstract

Background Measles is a highly communicable infection with potentially severe complications. It is rarely reported in high-income countries and the limited awareness and experience of pediatricians may result in misdiagnosis. The present study aimed at investigating physician's ability and timing to reach diagnosis during a recent outbreak in Italy. Methods The Italian Society for Pediatric Infectious Diseases conducted a retrospective, multicenter study in children hospitalized for measles between 1 January 2016 and 30 August 2017 in secondary and tertiary care hospitals. The appropriateness of diagnosis at admission, the time to reach clinical diagnosis, and serological confirmation of measles were recorded. Results At hospital admission, measles was misdiagnosed in 101 (40.5%) of the 249 children (median age, 14.5 months) enrolled. The appropriate diagnosis increased from 30% to 72.5% during the period of observation (P <.001). A greater chance of receiving an appropriate diagnosis was demonstrated in children who reported a contact with measles (odds ratio [OR], 5.2; 95% confidence interval [CI], 3.0–9.2) or in those seen in institutions that managed more cases (OR, 7.39; 95% CI, 3.22–16.9; P =.0001). In contrast, children with underlying chronic conditions had a higher risk of misdiagnosis (appropriate diagnosis OR, 0.19; 95% CI, 0.10–0.33). The mean time from the onset of symptoms to clinical diagnosis was 4.55 ± 2.2 days and to serological confirmation was 7.0 ± 3.4 days. Conclusions Measles is frequently misdiagnosed in low-prevalence settings. Specific measures to increase pediatricians' awareness about vaccine-preventable infections need to be implemented. [ABSTRACT FROM AUTHOR]

Published
2020
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34. Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020.

Author

Garazzino, Silvia, Montagnani, Carlotta, Donà, Daniele, Meini, Antonella, Felici, Enrico, Vergine, Gianluca, Bernardi, Stefania, Giacchero, Roberta, Lo Vecchio, Andrea, Marchisio, Paola, Nicolini, Giangiacomo, Pierantoni, Luca, Rabbone, Ivana, Banderali, Giuseppe, Denina, Marco, Venturini, Elisabetta, Krzysztofiak, Andrzej, Badolato, Raffaele, Bianchini, Sonia, and Galli, Luisa

Published
2020
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35. Risk factors associated with complications/sequelae of acute and subacute haematogenous osteomyelitis: an Italian multicenter study

Author

Chiappini, Elena, primary, Krzysztofiak, Andrzej, additional, Bozzola, Elena, additional, Gabiano, Clara, additional, Esposito, Susanna, additional, Lo Vecchio, Andrea, additional, Govoni, Maria Rita, additional, Vallongo, Cristina, additional, Dodi, Icilio, additional, Castagnola, Elio, additional, Rossi, Nadia, additional, Valentini, Piero, additional, Cardinale, Fabio, additional, Salvini, Filippo, additional, Bona, Gianni, additional, Bossi, Grazia, additional, Olivieri, Alma Nunzia, additional, Russo, Fiorella, additional, Fossali, Emilio, additional, Bottone, Gabriella, additional, Dellepiane, Marta, additional, De Martino, Maurizio, additional, Villani, Alberto, additional, and Galli, Luisa, additional

Published
2018
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39. Acute cerebellitis in children: An eleven year retrospective multicentric study in Italy

Author

Lancella, Laura, Esposito, Susanna, Galli, Maria Luisa, Bozzola, Elena, Labalestra, Valeria, Boccuzzi, Elena, Krzysztofiak, Andrzej, Cursi, Laura, Gattinara, Guido Castelli, Mirante, Nadia, Buonsenso, Danilo, Tagliabue, Claudia, Castellazzi, Luca, Montagnani, Carlotta, Tersigni, Chiara, Valentini, Piero, Capozza, Michele, Pata, Davide, Di Gangi, Maria, Dones, Piera, Garazzino, Silvia, Baroero, Luca, Verrotti, Alberto, Melzi, Maria Luisa, Sacco, Michele, Germano, Michele, Greco, Filippo, Uga, Elena, Crichiutti, Giovanni, Villani, Alberto, Valentini, Piero (ORCID:0000-0001-6095-9510), Lancella, Laura, Esposito, Susanna, Galli, Maria Luisa, Bozzola, Elena, Labalestra, Valeria, Boccuzzi, Elena, Krzysztofiak, Andrzej, Cursi, Laura, Gattinara, Guido Castelli, Mirante, Nadia, Buonsenso, Danilo, Tagliabue, Claudia, Castellazzi, Luca, Montagnani, Carlotta, Tersigni, Chiara, Valentini, Piero, Capozza, Michele, Pata, Davide, Di Gangi, Maria, Dones, Piera, Garazzino, Silvia, Baroero, Luca, Verrotti, Alberto, Melzi, Maria Luisa, Sacco, Michele, Germano, Michele, Greco, Filippo, Uga, Elena, Crichiutti, Giovanni, Villani, Alberto, and Valentini, Piero (ORCID:0000-0001-6095-9510)

Abstract

Background: Acute cerebellitis (AC) and acute cerebellar ataxia (ACA) are the principal causes of acute cerebellar dysfunction in childhood. Nevertheless. there is no accepted consensus regarding the best management of children with AC/ACA: the aim of the study is both to assess clinical, neuroimaging and electrophysiologic features of children with AC/ACA and to evaluate the correlation between clinical parameters, therapy and outcome. Methods: A multicentric retrospective study was conducted on children ≤ 18 years old admitted to 12 Italian paediatric hospitals for AC/ACA from 01/01/2003 to 31/12/2013. A score based on both cerebellar and extracerebellar signs/symptoms was computed for each patient. One point was given for each sign/symptom reported. Severity was divided in three classes: low, moderate, severe. Results: A total of 124 children were included in the study. Of these, 118 children received a final diagnosis of ACA and 6 of AC. The most characteristic finding of AC/ACA was a broad-based gait disturbance. Other common symptoms included balance disturbances, slurred speech, vomiting, headache and fever. Neurological sequelae were reported in 6 cases (5%) There was no correlation among symptoms, cerebrospinal fluid findings, clinical outcome. There was no correlation between clinical manifestations and clinical score on admission and length of hospital stay, sex, age and EEG findings with sequelae (P > 0.05). Children with pathological magnetic resonance imaging (MRI) or computed tomography (CT) had a higher probability of having clinical sequelae. Treatment was decided independently case by case. Patients with a higher clinical score on admission had a higher probability of receiving intravenous steroids. Conclusions: We confirmed the literature data about the benign course of AC/ACA in most cases but we also highlighted a considerable rate of patients with neurological sequelae (5%). Pathological MRI or CT findings at admission correlate to neurologi

Published
2017

40. Daptomycin for children in clinical practice experience

Author

Garazzino, Silvia, Castagnola, Elio, Di Gangi, Maria, Ortolano, Rita, Krzysztofiak, Andrzej, Nocerino, Agostino, Esposito, Susanna, D'Argenio, Patrizia, Galli, Luisa, Losurdo, Giuseppe, Calitri, Carmelina, Tovo, Pier Angelo, for the SITIP Daptomycin Study Group including Bandettini, Roberto, Giordano, Salvatore, Dones, Piera, Ziino, Ottavio, Mosa, Clara, Robazza, Margherita, Tagliabue, Claudia, Lancella, Laura, and Carraro, Francesca

Subjects
Male, 0301 basic medicine, Pediatrics, medicine.disease_cause, 0302 clinical medicine, polycyclic compounds, 030212 general & internal medicine, Child, Children, Medicine (all), Osteomyelitis, Bacterial Infections, Perinatology and Child Health, Anti-Bacterial Agents, Clinical Practice, Infectious Diseases, Child, Preschool, Administration, Intravenous, Female, lipids (amino acids, peptides, and proteins), Daptomycin, Methicillin-resistant Staphylococcus aureus, Sepsis, Pediatrics, Perinatology and Child Health, Microbiology (medical), medicine.drug, medicine.medical_specialty, Adolescent, Drug-Related Side Effects and Adverse Reactions, 030106 microbiology, 03 medical and health sciences, medicine, Humans, Adverse effect, Retrospective Studies, business.industry, Infant, Newborn, Infant, Retrospective cohort study, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, carbohydrates (lipids), business, Prolonged treatment
Abstract

Data on daptomycin use in the pediatric setting are scanty. We conducted a multicenter, retrospective study on 46 children treated with intravenous daptomycin at a mean dosage of 7.0 mg/kg/d, for a median of 14 days. Three children had adverse events possibly related to daptomycin. The drug was overall well tolerated, even with prolonged treatment.

Published
2016

42. Acute cerebellitis in children: an eleven year retrospective multicentric study in Italy

Author

Lancella, Laura, primary, Esposito, Susanna, additional, Galli, Maria Luisa, additional, Bozzola, Elena, additional, Labalestra, Valeria, additional, Boccuzzi, Elena, additional, Krzysztofiak, Andrzej, additional, Cursi, Laura, additional, Gattinara, Guido Castelli, additional, Mirante, Nadia, additional, Buonsenso, Danilo, additional, Tagliabue, Claudia, additional, Castellazzi, Luca, additional, Montagnani, Carlotta, additional, Tersigni, Chiara, additional, Valentini, Piero, additional, Capozza, Michele, additional, Pata, Davide, additional, Di Gangi, Maria, additional, Dones, Piera, additional, Garazzino, Silvia, additional, Baroero, Luca, additional, Verrotti, Alberto, additional, Melzi, Maria Luisa, additional, Sacco, Michele, additional, Germano, Michele, additional, Greco, Filippo, additional, Uga, Elena, additional, Crichiutti, Giovanni, additional, and Villani, Alberto, additional

Published
2017
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43. 72nd Congress of the Italian Society of Pediatrics

Author

Braghero, Marco, primary, Staiano, Annamaria, additional, Biasin, Eleonora, additional, Matarazzo, Patrizia, additional, Einaudi, Silvia, additional, Manicone, Rosaria, additional, Felicetti, Francesco, additional, Brignardello, Enrico, additional, Fagioli, Franca, additional, Bignamini, Elisabetta, additional, Nave, Elena, additional, Callea, F., additional, Concato, C., additional, Fiscarelli, E., additional, Garrone, S., additional, de Gasperis, M.Rossi, additional, Calzi, Patrizia, additional, Marinelli, Grazia, additional, Besana, Roberto, additional, Caffarelli, Carlo, additional, Di Peri, Antonio, additional, Lapetina, Irene, additional, Cincinnati, Patrizia, additional, Da Riol, Rosalia Maria, additional, De Curtis, Mario, additional, Dito, Lucia, additional, Protano, Chiara, additional, Esposito, Susanna, additional, Ferrara, Dante, additional, Galiano, Rossella, additional, Novellino, Pasquale, additional, Kossoff, Eric Heath, additional, Krzysztofiak, Andrzej, additional, Bozzola, Elena, additional, Lancella, Laura, additional, Marchesi, Alessandra, additional, Villani, Alberto, additional, Lago, Paola, additional, Garetti, Elisabetta, additional, Pirelli, Anna, additional, Marchisio, Paola, additional, Santagati, Maria, additional, Stefani, Stefania, additional, Principi, Nicola, additional, d’Apolito, Valeria, additional, Memo, Luigi, additional, Selicorni, Angelo, additional, Miniello, Vito Leonardo, additional, Diaferio, Lucia, additional, Palmieri, Antonella, additional, Parola, Luciana, additional, Piro, Ettore, additional, Romano, Claudio, additional, Catena, Maria Ausilia, additional, Cardile, Sabrina, additional, Sacco, Oliviero, additional, Girosi, Donata, additional, Olcese, Roberta, additional, Tosca, Mariangela, additional, Rossi, Giovanni Arturo, additional, Salerno, Sergio, additional, Terranova, Maria Chiara, additional, Santamaria, Francesca, additional, Mancano, Giorgia, additional, Maitz, Silvia, additional, Stallings, Virginia A., additional, Berlolaso, Chiara, additional, McAnlis, Carolyn, additional, Schall, Joan I., additional, Striano, Pasquale, additional, Tanas, Rita, additional, De Iaco, Giulia, additional, Marsella, Maria, additional, Caggese, Guido, additional, Toma, Paolo, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Pata, David, additional, Ceccarelli, Manuela, additional, Verduci, Elvira, additional, Brambilla, Marta, additional, Mariani, Benedetta, additional, Lassandro, Carlotta, additional, Dionigi, Alice Re, additional, Vizzuso, Sara, additional, Banderali, Giuseppe, additional, Panzarino, Gianvito, additional, Di Paolantonio, Claudia, additional, Verrotti, Alberto, additional, Cursi, Laura, additional, Grandin, Annalisa, additional, Virdis, Raffaele, additional, Carletti, Patrizia, additional, Weber, Giovanna, additional, Caiulo, Silvana, additional, and Vigone, Maria Cristina, additional

Published
2017
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44. Measles Outbreak in a High-Income Country: Are Pediatricians Ready?

Author

Lo Vecchio, Andrea, Montagnani, Carlotta, Krzysztofiak, Andrzej, Valentini, Piero, Rossi, Nadia, Bozzola, Elena, Castelli Gattinara, Guido, Magurano, Fabio, Guarino, Alfredo, and Galli, Luisa

Abstract

Measles is a highly communicable infection with potentially severe complications. It is rarely reported in high-income countries and the limited awareness and experience of pediatricians may result in misdiagnosis. The present study aimed at investigating physician's ability and timing to reach diagnosis during a recent outbreak in Italy.

Published
2020
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45. Daptomycin for Children in Clinical Practice Experience

Author

Garazzino, Silvia, primary, Castagnola, Elio, additional, Di Gangi, Maria, additional, Ortolano, Rita, additional, Krzysztofiak, Andrzej, additional, Nocerino, Agostino, additional, Esposito, Susanna, additional, D’Argenio, Patrizia, additional, Galli, Luisa, additional, Losurdo, Giuseppe, additional, Calitri, Carmelina, additional, and Tovo, Pier-Angelo, additional

Published
2016
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48. Infective Endocarditis in Children in Italy from 2000 to 2015.

Author

Esposito, Susanna, Mayer, Alessandra, Krzysztofiak, Andrzej, Garazzino, Silvia, Lipreri, Rita, Galli, Luisa, Osimani, Patrizia, Fossali, Emilio, Di Gangi, Maria, Lancella, Laura, Denina, Marco, Pattarino, Giulia, Montagnani, Carlotta, Salvini, Filippo, Villani, Alberto, Principi, Nicola, for the Italian Pediatric Infective Endocarditis Registry, and Italian Pediatric Infective Endocarditis Registry

Subjects
HEART disease complications, ENDOCARDITIS, DRUG resistance in microorganisms, STAPHYLOCOCCAL diseases, STAPHYLOCOCCUS aureus, STREPTOCOCCAL diseases, ACQUISITION of data, CROSS-sectional method, VIRIDANS strepotococci, METHICILLIN-resistant staphylococcus aureus, DISEASE complications
Abstract

Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable. [ABSTRACT FROM AUTHOR]

Published
2016
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