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8. SARS-CoV-2 Serology and Self-Reported Infection Among Adults--National Health and Nutrition Examination Survey, United States, August 2021-May 2022

Author

Akinbami, Lara J., Kruszon-Moran, Deanna, Wang, Chia-Yih, Storandt, Renee J., Clark, Jason, Riddles, Minsun K., and Mohadjer, Leyla K.

Subjects
United States. National Center for Health Statistics -- Surveys, Diseases, Surveys, Health surveys -- Surveys, Vaccination -- Surveys, Antibodies -- Surveys, COVID-19 -- Surveys, Blood donation -- Surveys, Adults -- Surveys, Viral antibodies -- Surveys, Blood donors -- Surveys
Abstract

CDC COVID-19 surveillance systems monitor SARS-CoV-2 antibody prevalence to collect information about asymptomatic, undiagnosed, and unreported disease using national convenience samples of blood donor data from commercial laboratories (1,2). However, [...]

Published
2022

22. Association of infection with Toxoplasma gondii and Toxocara on cognitive function among US adults aged 60 and over, NHANES 2011-2014.

Author

Kruszon-Moran, Deanna, Brody, Debra, and Pearce, Bradley

Subjects
STATISTICS, NEMATODE infections, IMMUNOGLOBULINS, MULTIVARIATE analysis, TOXOPLASMOSIS, SURVEYS, COMPARATIVE studies, SOCIOECONOMIC factors, PROTOZOAN diseases, MIXED infections, DESCRIPTIVE statistics, COGNITION disorders in old age, LOGISTIC regression analysis, SOCIODEMOGRAPHIC factors, DISEASE complications
Published
2023
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26. Assessing consent for and response to health survey components in an era of falling response rates: National Health and Nutrition Examination Survey, 2011–2018

Author

McQuillan, Geraldine, Kruszon-Moran, Deanna, Di, Hua, Schaar, Denise, Lukacs, Susan, Fakhouri, Tala, Tolliver, Eric, and Paulose-Ram, Ryne

Subjects
Article
Abstract

Response rates for national population-based surveys have declined, including the National Health and Nutrition Examination Survey (NHANES). Declining response to the initial NHANES interview may impact consent and participation in downstream survey components such as record linkage, physical exams, storage of biological samples and phlebotomy. Interview response rates dropped from 67.7% in 2011-2012 to 53.1% in 2017-2018 for adults age 18 and older. Response was higher for children (1-17 years) but with a similar downward trend (2011-2012, 81.2%; 2017-2018, 64.7%). Despite declining interview response rates, changes in consent and response rates for downstream components over time have been mixed. Among those interviewed, the examination response rate was over 93%, consent for record linkage was over 90%, and consent for storage of specimens for future research was over 99%. The availability of a blood sample for storage ranged between 60%-63% for children and 78%-85% for adults., Survey Research Methods, Vol 15 No 3 (2021)

Published
2021

29. Varicella seroprevalence in the U.S.: data from the National Health and Nutrition Examination Survey, 1999-2004

Author

Reynolds, Meredith A., Kruszon-Moran, Deanna, Jumaan, Aisha, Schmid, D. Scott, and McQuillan, Geraldine M.

Subjects
Immune response -- Demographic aspects, Immune response -- Research, Chickenpox -- Distribution, Chickenpox -- Demographic aspects, Chickenpox -- Surveys, Prevalence studies (Epidemiology) -- Reports, False positive reactions -- Reports, Immune system -- Testing, Immune system -- Usage, Immune system -- Demographic aspects, Immune system -- Research, Company distribution practices
Published
2010

31. Prevalence of HIV in the US household population: The National Health and Nutrition Examination Surveys, 1988 to 2002

Author

Mcquillan, Geraldine M., Kruszon-Moran, Deanna, Kottiri, Benny J., Kamimoto, Laurie A., Lee Lam, Cowart, M. Faye, Hubbard, Marjorie, and Spira, Thomas J.

Subjects
HIV infection -- Health aspects, HIV patients -- Health aspects, HIV patients -- Surveys, Health
Abstract

The National Health and Nutrition Examination Surveys (NHANES) are a series of cross-sectional surveys designed to provide national statistics on the health and nutritional status of the general household population through household interviews, standardized physical examinations, and the collection of biologic samples in special mobile examination centers. In NHANES III, race and/or ethnicity was categorized as non-Hispanic white, non-Hispanic African American and Mexican American.

Published
2006

32. Racial and ethnic differences in the seroprevalence of 6 infectious diseases in the United States: data from NHANES III, 1988-1994

Author

McQuillan, Geraldine M., Kruszon-Moran, Deanna, Kottiri, Benny J., Curtin, Lester R., Lucas, Jacqueline W., and Kington, Raynard S.

Subjects
Communicable diseases -- Research, Communicable diseases -- Social aspects, Government, Health care industry
Abstract

Objectives. We examined racial/ethnic differences in the seroprevalence of selected infectious agents in analyses stratified according to risk categories to identify patterns and to determine whether demographic, socioeconomic, and behavioral characteristics explain these differences. Methods. We analyzed data from the third National Health and Nutrition Examination Survey, comparing differences among groups in regard to the prevalence of infection with hepatitis A, B, and C viruses, Toxoplasma gondii, Helicobacter pylori, and herpes simplex virus type 2. Results. Racial/ethnic differences were greater among those in the low-risk category. In the case of most infectious agents, odds associated with race/ethnicity were almost 2 times greater in that category than in the high-risk category. Conclusions. Stratification and adjustment for socioeconomic factors reduced or eliminated racial/ethnic differences in the prevalence of infection in the high-risk but not the low-risk group, wherein race/ethnicity remained significant and might have been a surrogate for unmeasured risk factors.

Published
2004

33. Association of infection with Toxoplasma gondiiand Toxocaraon cognitive function among US adults aged 60 and over, NHANES 2011–2014

Author

Kruszon-Moran, Deanna, Brody, Debra, and Pearce, Bradley

Abstract

BackgroundToxoplasma gondiiand Toxocaraare common parasites that infect humans globally. Our aim was to examine the relationship between T. gondiiand Toxocarainfection and cognition.MethodsMultivariate logistic regression was used to test the association of T. gondiiand Toxocaraseropositivity on indices of cognitive function (a word list learning trial with delayed recall from the Consortium to Establish a Registry for Alzheimer’s Disease, an animal fluency test (AFT) and a digit symbol substitution test (DSST)) among 2643 adults aged 60 years and older in the 2011–2014 National Health and Nutrition Examination Survey.ResultsSeropositivity to T. gondiior Toxocarawere both associated with lower scores in all three cognitive function measures examined in univariate analyses. Except for the DSST, these associations were not significant after adjustment for age, gender, race and Hispanic origin, poverty level, education, US birth status, depression and hypertension. On stratification to account for significant interactions, Toxocaraseropositivity was associated with worse scores on the AFT among those born outside the USA, worse scores on the DSST among those aged 60–69 years, female, Hispanic and with a high school diploma or less. Lower DSST scores with Toxocarainfection was greater for adults living below compared with at or above the poverty level.ConclusionsSeropositivity to these parasites, particularly to Toxocara, may be associated with diminished cognitive performance in certain subgroups of older adults.

Published
2023
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34. Toxoplasma gondii infection in the United States, 1999-2000

Author

Jones, Jeffrey L., Kruszon-Moran, Deanna, and Wilson, Marianna

Subjects
Research, Health aspects, Toxoplasma -- Health aspects -- Research
Abstract

Infection with Toxoplasma gondii can lead to congenital and acquired disease, resulting in loss of vision and neurologic illness. We tested sera collected in the National Health and Examination Survey [...]

Published
2003

36. The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States

Author

Dye, Bruce A., Kruszon-Moran, Deanna, and McQuillan, Geraldine

Subjects
Helicobacter infections -- Risk factors, Periodontal disease -- Complications, Comorbidity -- Analysis, Government, Health care industry
Abstract

Objectives. We investigated the relationship between Helicobacter pylori infection and abnormal periodontal conditions. Methods. Data from the first phase of the third National Health and Nutrition Examination Survey were used. A total of 4504 participants aged 20 to 59 years who completed a periodontal examination and tested positive for H. pylori antibodies were examined. Results. Periodontal pockets with a depth of 5 mm or more were associated with increased odds of H. pylori seropositivity (odds ratio [OR] = 1.47; 95% confidence interval [CI] = 1.12, 1.94) after adjustment for sociodemographic factors. This association is comparable to the independent effects of poverty on H. pylori (OR = 1.54; 95% CI = 1.10, 2.16). Conclusions. Poor periodontal health, characterized by advanced periodontal pockets, may be associated with H. pylori infection in adults, independent of poverty Status.

Published
2002

38. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994

Author

Alter, Miriam J., Kruszon-Moran, Deanna, Nainan, Omana V., McQuillan, Geraldine M., Gao, Fengxiang, Moyer, Linda A., Kaslow, Richard A., and Margolis, Harold S.

Subjects
Hepatitis C -- Statistics
Abstract

An estimated 4 million Americans are infected with the hepatitis C virus and 2.7 million are chronically infected, according to blood tests on 21,241 people participating in the third National Health and Nutrition Examination between 1988 and 1994. The biggest risk factors in this sample of people were illegal drug use and risky sexual practices. Poverty, lack of education and being divorced or separated were also risk factors.

Published
1999

47. Prevalence of hepatitis C virus infection in the United States

Author

Murphy, Edward L., Bryzman, Stephen, Williams, Alan E., Dore, Gregory J., Law, Matthew G., Kaldor, John M., Stroffolini, Tommaso, D'Argenio, Paolo, Mele, Alfonso, Alter, Miriam J., Kruszon-Moran, Deanna, and McQuillan, Geraldine M.

Subjects
Hepatitis C -- Statistics
Published
1999

48. An unusually high prevalence of ocular toxoplasmosis in Southern Brazil

Author

Glasner, Peter D., Silveira, Claudio, Kruszon-Moran, Deanna, Martins, Maria C., Burnier, Miguel, Jr., Silveira, Silvia, Camargo, Mario E., Nussenblatt, Robert B., Kaslow, Richard A., and Belfort, Rubens, Jr.

Subjects
Brazil -- Health aspects, HIV infection -- Complications, AIDS (Disease) -- Complications, Toxoplasmosis, Ocular -- Diagnosis, Health
Published
1992

50. Influence of Parity and Sexual History on Cytomegalovirus Seroprevalence among Women 20-49 Years-old in the United States, 1999-2004

Author

Lanzieri, Tatiana M., Kruszon-Moran, Deanna, Gambhir, Manoj, and Bialek, Stephanie R.

Subjects
Adult, Sexual Behavior, Cytomegalovirus, Middle Aged, Antibodies, Viral, Nutrition Surveys, Article, United States, Parity, Young Adult, Age Distribution, Logistic Models, Pregnancy, Risk Factors, Seroepidemiologic Studies, Cytomegalovirus Infections, Odds Ratio, Humans, Female, Retrospective Studies
Abstract

To assess the influence of parity, as a proxy for exposure to children, and sexual history on cytomegalovirus (CMV) seroprevalence.Data were retrospectively analyzed from women aged 20-49 years who were tested for CMV immunoglobulin G antibodies in the 1999-2004 National Health and Nutrition Examination Survey, a nationally representative survey of the US population. Logistic regression was used to determine independent variables associated with CMV seroprevalence.Among 3710 women, the age-adjusted CMV seroprevalence was 61.3% (95% CI 58.9%-63.6%). In age-adjusted univariate analysis, women who had given birth at least once had higher overall CMV seroprevalence (66.0%, 95% CI 63.1%-68.9%) than did those who had not given birth (49.0%, 95% CI 44.4%-53.7%; P0.001). In multivariate logistic analysis, higher CMV seroprevalence was independently associated with number of live births (each additional birth: adjusted odds ratio [aOR] 1.2, 95% CI 1.1-1.3), age at first sexual intercourse (18 vs ≥18years: aOR 1.3, 95% CI 1.1-1.6), lifetime sexual partners (≥10 vs10: aOR 1.4, 95% CI 1.1-1.9), and herpes type 2 seropositivity (aOR 1.9, 95% CI 1.5-2.6) after controlling for age, race/Hispanic origin, place of birth, poverty index, and education.Among US women of reproductive age, parity and sexual exposures were independently associated with increased CMV seroprevalence.

Published
2016

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