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9 results on '"Kruszelnicki, Irma"'

1. Synthesis and biological evaluation of some enantiomerically pure C8c-C15-monoseco analogues of the phenanthroquinolizidine-type alkaloids cryptopleurine and julandine

Author

Sydnes, Magne, Bezos, Anna, Burns, Christopher, Kruszelnicki, Irma, Su, Stephen, Rae, A David, Willis, Anthony, Banwell, Martin, Parish, Christopher, Sydnes, Magne, Bezos, Anna, Burns, Christopher, Kruszelnicki, Irma, Su, Stephen, Rae, A David, Willis, Anthony, Banwell, Martin, and Parish, Christopher

Abstract

A series of enantiomerically pure C8cC15 monoseco analogues, 2330, of the alkaloids cryptopleurine (1) and julandine (2) have been prepared using cinnamyl chloride 37 and (S)- or (R)-2-methylpiperidine as key building blocks. Two related compounds, 31 and 32, have also been synthesized. Each of these analogues has been subjected to various biological evaluations and most of them show dramatically reduced cytotoxicity compared with parent system 1. Nevertheless, they are potent anti-angiogenic agents. The formation and single-crystal X-ray analysis of the spirocyclic dienone 54, a by-product arising from attempts to prepare analogue 32, is also described.

Published
2008

2. C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties

Author

Banwell, Martin, Bezos, Anna, Burns, Christopher, Kruszelnicki, Irma, Su, Stephen, Sydnes, Magne, Parish, Christopher, Banwell, Martin, Bezos, Anna, Burns, Christopher, Kruszelnicki, Irma, Su, Stephen, Sydnes, Magne, and Parish, Christopher

Abstract

Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.

Published
2006

3. The synthesis and biological evaluation of two analogues of the C-riboside showdomycin

Author

Renner, Jens, Kruszelnicki, Irma, Adamiak, Beata, Willis, Anthony, Hammond, Edward, Su, Stephen, Burns, Christopher, Trybala, Edward, Ferro, Vito, Banwell, Martin, Renner, Jens, Kruszelnicki, Irma, Adamiak, Beata, Willis, Anthony, Hammond, Edward, Su, Stephen, Burns, Christopher, Trybala, Edward, Ferro, Vito, and Banwell, Martin

Published
2005

4. CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo

Author

Burns, Christopher J., primary, Fantino, Emmanuelle, additional, Phillips, Ian D., additional, Su, Stephen, additional, Harte, Michael F., additional, Bukczynska, Patricia E., additional, Frazzetto, Mark, additional, Joffe, Max, additional, Kruszelnicki, Irma, additional, Wang, Bing, additional, Wang, Yue, additional, Wilson, Neil, additional, Dilley, Rodney J., additional, Wan, Soo S., additional, Charman, Susan A., additional, Shackleford, David M., additional, Fida, Rosa, additional, Malcontenti-Wilson, Cathy, additional, and Wilks, Andrew F., additional

Published
2009
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