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8. 0863 Sleep Behaviors And Patterns In Adult Survivors Of Childhood Cancers: A Report From The Childhood Cancer Survivor Study (CCSS)

Author

Daniel, L C, primary, Wang, M, additional, Srivastava, D, additional, Schwartz, L, additional, Brinkman, T, additional, Edelstein, K, additional, Mulrooney, D, additional, Zhou, E, additional, Howell, R, additional, Gibson, T, additional, Leisenring, W, additional, Armstrong, G T, additional, and Krull, K, additional

Published
2018
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9. Technology-Enabled Remote Monitoring and Self-Management — Vision for Patient Empowerment Following Cardiac and Vascular Surgery: User Testing and Randomized Controlled Trial Protocol

Author

Tracey J.F. Colella, Michael Stacey, Lehana Thabane, Krull K, Sharon Kaasalainen, Christopher Lawton, Robert S. McKelvie, Bonnie J. Stevens, Russell-Wood K, Joel Katz, Naus F, James S. Khan, J.C. Victor, Sem Ponnambalam, Sanjeev P. Bhavnani, Andy Turner, J. Watt-Watson, Amber Good, Maria Ricupero, Sider K, Sheila O'Keefe-McCarthy, Elizabeth Peter, John J McNeil, Probst C, Arthur G, Ladak S, Wendy Clyne, R.M. Khan, Taryn Scott, Sarah Sharpe, Gamble D, D. I. Sessler, Bhella S, Peter Liu, Weber M, Gill Furze, Romeril E, Jason W. Busse, Lakhani N, Manon Choinière, Bender D, Andre Lamy, Monica Parry, Joseph L. Mills, Philip J. Devereaux, Travale I, Robyn Stremler, Alpert R, Nazari Dvirnik, Hillmer M, Farrow M, Wanrudee Isaranuwatchai, Paul Ritvo, David Mohajer, Marit Leegaard, Richard P. Whitlock, Laurie Poole, Susan M. Pettit, Mark Field, Joy C. MacDermid, Sandra LeFort, Lynn Cooper, Janine Duquette, Lee J, Taberner C, Michael McGillion, Sandra L Carroll, Sven Oliver, Boyajian K, Dunlop, David Cowan, Jennifer Yost, Judith M. E. Walsh, Shaunattonie Henry, Jeffrey S Hoch, Gossage E, and Bedini D

Subjects
medicine.medical_specialty, Proposal, Context (language use), technology-enabled self-management, 030204 cardiovascular system & hematology, law.invention, usability testing, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Randomized controlled trial, law, Health care, medicine, Clinical endpoint, eHealth, 030212 general & internal medicine, remote automated external monitoring, business.industry, General Medicine, Vascular surgery, 3. Good health, randomized controlled trial, Physical therapy, Geriatric Depression Scale, business
Abstract

Background: Tens of thousands of cardiac and vascular surgeries (CaVS) are performed on seniors in Canada and the United Kingdom each year to improve survival, relieve disease symptoms, and improve health-related quality of life (HRQL). However, chronic postsurgical pain (CPSP), undetected or delayed detection of hemodynamic compromise, complications, and related poor functional status are major problems for substantial numbers of patients during the recovery process. To tackle this problem, we aim to refine and test the effectiveness of an eHealth-enabled service delivery intervention, TecHnology-Enabled remote monitoring and Self-MAnagemenT—VIsion for patient EmpoWerment following Cardiac and VasculaR surgery (THE SMArTVIEW, CoVeRed), which combines remote monitoring, education, and self-management training to optimize recovery outcomes and experience of seniors undergoing CaVS in Canada and the United Kingdom. Objective: Our objectives are to (1) refine SMArTVIEW via high-fidelity user testing and (2) examine the effectiveness of SMArTVIEW via a randomized controlled trial (RCT). Methods: CaVS patients and clinicians will engage in two cycles of focus groups and usability testing at each site; feedback will be elicited about expectations and experience of SMArTVIEW, in context. The data will be used to refine the SMArTVIEW eHealth delivery program. Upon transfer to the surgical ward (ie, post-intensive care unit [ICU]), 256 CaVS patients will be reassessed postoperatively and randomly allocated via an interactive Web randomization system to the intervention group or usual care. The SMArTVIEW intervention will run from surgical ward day 2 until 8 weeks following surgery. Outcome assessments will occur on postoperative day 30; at week 8; and at 3, 6, 9, and 12 months. The primary outcome is worst postop pain intensity upon movement in the previous 24 hours (Brief Pain Inventory-Short Form), averaged across the previous 14 days. Secondary outcomes include a composite of postoperative complications related to hemodynamic compromise—death, myocardial infarction, and nonfatal stroke— all-cause mortality and surgical site infections, functional status (Medical Outcomes Study Short Form-12), depressive symptoms (Geriatric Depression Scale), health service utilization-related costs (health service utilization data from the Institute for Clinical Evaluative Sciences data repository), and patient-level cost of recovery (Ambulatory Home Care Record). A linear mixed model will be used to assess the effects of the intervention on the primary outcome, with an a priori contrast of weekly average worst pain intensity upon movement to evaluate the primary endpoint of pain at 8 weeks postoperation. We will also examine the incremental cost of the intervention compared to usual care using a regression model to estimate the difference in expected health care costs between groups. Results: Study start-up is underway and usability testing is scheduled to begin in the fall of 2016. Conclusions: Given our experience, dedicated industry partners, and related RCT infrastructure, we are confident we can make a lasting contribution to improving the care of seniors who undergo CaVS. [JMIR Res Protoc 2016;5(3):e149]

Published
2016

11. Long-term functional outcomes and quality of life in adult survivors of childhood extremity sarcomas: a report from the St. Jude Lifetime Cohort Study

Author

Fernandez-Pineda, Israel, primary, Hudson, M. M., additional, Pappo, A. S., additional, Bishop, M. W., additional, Klosky, J. L., additional, Brinkman, T. M., additional, Srivastava, D. K., additional, Neel, M. D., additional, Rao, B. N., additional, Davidoff, A. M., additional, Krull, K. R., additional, Mulrooney, D. A., additional, Robison, L. L., additional, and Ness, K. K., additional

Published
2016
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12. QUALITY OF LIFE/AFTERCARE

Author

Strobel, K., primary, Simpson, P., additional, Donohoue, P., additional, Firat, S., additional, Jogal, S., additional, Lai, J.-S., additional, Beaumont, J., additional, Goldman, S., additional, Huang, C., additional, Barrera, M., additional, Rokeach, A., additional, Hancock, K., additional, Cataudella, D., additional, Schulte, F., additional, Chung, J., additional, Bartels, U., additional, Janzen, L., additional, Sung, L., additional, Strother, D., additional, Hukin, J., additional, Downie, A., additional, Zelcer, S., additional, Atenafu, E., additional, Schiavello, E., additional, Biassoni, V., additional, Meazza, C., additional, Podda, M., additional, Massimino, M., additional, Wells, E. M., additional, Ullrich, N. J., additional, Seidel, K., additional, Leisenring, W., additional, Sklar, C., additional, Armstrong, G. T., additional, Diller, L., additional, King, A., additional, krull, K., additional, Neglia, J. P., additional, Stovall, M., additional, Whelan, K., additional, Robison, L. L., additional, Packer, R. J., additional, Remes, T., additional, Harila-Saari, A., additional, Suo-Palosaari, M., additional, Lahteenmaki, P., additional, Arikoski, P., additional, Riikonen, P., additional, Rantala, H., additional, Ojaniemi, M., additional, Bull, K., additional, Kennedy, C., additional, Bailey, S., additional, Ellison, D., additional, Clifford, S., additional, Dembowska-Baginska, B., additional, Brozyna, A., additional, Drogosiewicz, M., additional, Perek-Polnik, M., additional, Swieszkowska, E., additional, Filipek, I., additional, Tarasinska, M., additional, Korzeniewska, J., additional, Perek, D., additional, Salgado, D., additional, Nunes, S., additional, Pereira, P., additional, Vinhais, S., additional, Salih, S., additional, Elsarrag, S., additional, Prange, E., additional, Contreas, K., additional, Possin, P., additional, Frierdich, S., additional, Eickhoff, J., additional, Puccetti, D., additional, Ladas, E., additional, Buck, C., additional, Arbit, N., additional, Gudrunardottir, T., additional, Lannering, B., additional, Remke, M., additional, Taylor, M. D., additional, Keating, R. F., additional, Stapleton, S., additional, Flanary, J., additional, Hamblin, F., additional, Amankwah, E., additional, Ghazarian, S., additional, Jagt, C. T., additional, van de Wetering, M., additional, Schouten-van Meeteren, A. Y. N., additional, Nowinski, C., additional, Hartsell, W., additional, Chang, J. H.-C., additional, Cella, D., additional, Krishna, U., additional, Nagrulkar, A., additional, Takle, M., additional, Kannan, S., additional, Gupta, T., additional, Jalali, R., additional, Northman, L., additional, Morris, M., additional, Ross, S., additional, Guo, D., additional, Chordas, C., additional, Liptak, C., additional, Delaney, B., additional, Ullrich, N., additional, Manley, P., additional, Avula, S., additional, Pizer, B., additional, Ong, C. C., additional, Harave, S., additional, Mallucci, C., additional, Kumar, R., additional, Margol, A., additional, Finlay, J., additional, Dhall, G., additional, Robison, N., additional, Krieger, M., additional, Kiehna, E., additional, Coates, T., additional, Nelson, M., additional, Grimm, J., additional, Evans, A., additional, Nelson, M. B., additional, Britt, B., additional, Cooksey, R., additional, Wu, S., additional, Gode, A., additional, Klesse, L., additional, Oden, J., additional, Vega, G., additional, Gargan, L., additional, Bowers, D., additional, Madden, J. R., additional, Prince, E., additional, Zeitler, P., additional, Foreman, N. K., additional, and Liu, A. K., additional

Published
2014
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13. NEUROPSYCHOLOGY

Author

Boman, K. K., primary, Hornquist, L., additional, Rickardsson, J., additional, Lannering, B., additional, Gustafsson, G., additional, Pitchford, N., additional, Davis, E., additional, Walker, D., additional, Hoang, D. H., additional, Pagnier, A., additional, Cousin, E., additional, Guichardet, K., additional, Schiff, I., additional, Dubois-Teklali, F., additional, Krainik, A., additional, Lazar, M. B., additional, Resnik, K., additional, Olsson, I. T., additional, Perrin, S., additional, Burtscher, I. B., additional, Lundgren, J., additional, Kahn, A., additional, Johanson, A., additional, Korzeniewska, J., additional, Dembowska-Baginska, B., additional, Perek-Polnik, M., additional, Walsh, K., additional, Gioia, A., additional, Wells, E., additional, Packer, R., additional, de Speville, E. D., additional, Dufour, C., additional, Bolle, S., additional, Giraudat, K., additional, Longaud, A., additional, Kieffer, V., additional, Grill, J., additional, Puget, S., additional, Valteau-Couanet, D., additional, Hetz-Pannier, L., additional, Noulhiane, M., additional, Chieffo, D., additional, Tamburrini, G., additional, Caldarelli, M., additional, Di Rocco, C., additional, Margelisch, K., additional, Studer, M., additional, Steinlin, M., additional, Leibundgut, K., additional, Heinks, T., additional, Longaud-Vales, A., additional, Chevignard, M., additional, Pujet, S., additional, Sainte-Rose, C., additional, Dellatolas, G., additional, Kahalley, L., additional, Grosshans, D., additional, Paulino, A., additional, Ris, M. D., additional, Chintagumpala, M., additional, Okcu, F., additional, Moore, B., additional, Stancel, H., additional, Minard, C., additional, Guffey, D., additional, Mahajan, A., additional, Herrington, B., additional, Raiker, J., additional, Manning, E., additional, Criddle, J., additional, Karlson, C., additional, Guerry, W., additional, Finlay, J., additional, Sands, S., additional, Dockstader, C., additional, Skocic, J., additional, Bouffet, E., additional, Laughlin, S., additional, Tabori, U., additional, Mabbott, D., additional, Moxon-Emre, I., additional, Scantlebury, N., additional, Taylor, M. D., additional, Malkin, D., additional, Law, N., additional, Kumabe, T., additional, Leonard, J., additional, Rubin, J., additional, Jung, S., additional, Kim, S.-K., additional, Gupta, N., additional, Weiss, W., additional, Faria, C., additional, Vibhakar, R., additional, Spiegler, B., additional, Janzen, L., additional, Liu, F., additional, Decker, L., additional, Lemiere, J., additional, Vercruysse, T., additional, Haers, M., additional, Vandenabeele, K., additional, Geuens, S., additional, Jacobs, S., additional, Van Gool, S., additional, Riggs, L., additional, Piscione, J., additional, Timmons, B., additional, Cunningham, T., additional, Bartels, U., additional, Chakravarty, M., additional, Laperriere, N., additional, Pipitone, J., additional, Strother, D., additional, Hukin, J., additional, Fryer, C., additional, McConnell, D., additional, Secco, D. E., additional, Cappelletti, S., additional, Gentile, S., additional, Cacchione, A., additional, Del Bufalo, F., additional, Staccioli, S., additional, Spagnoli, A., additional, Messina, R., additional, Carai, A., additional, Marras, C. E., additional, Mastronuzzi, A., additional, Brinkman, T., additional, Armstrong, G., additional, Kimberg, C., additional, Gajjar, A., additional, Srivastava, D. K., additional, Robison, L., additional, Hudson, M., additional, Krull, K., additional, Hardy, K., additional, Hostetter, S., additional, Hwang, E., additional, Leiss, U., additional, Bemmer, A., additional, Pletschko, T., additional, Grafeneder, J., additional, Schwarzinger, A., additional, Deimann, P., additional, Slavc, I., additional, Batchelder, P., additional, Wilkening, G., additional, Hankinson, T., additional, Foreman, N., additional, and Handler, M., additional

Published
2014
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17. NEUROPSYCHOLOGY

Author

Brinkman, T., primary, Liu, W., additional, Armstrong, G., additional, Gajjar, A., additional, Merchant, T., additional, Kimberg, C., additional, Kun, L., additional, Srivastava, D. K., additional, Gurney, J., additional, Robison, L., additional, Hudson, M., additional, Krull, K., additional, Rubens, J., additional, Lulla, R. R., additional, Lai, J.-S., additional, Fangusaro, J., additional, Wolfe, K., additional, Madan-Swain, A., additional, Reddy, A., additional, Hunter, G., additional, Banos, J., additional, Kana, R., additional, Resch, A., additional, von Hoff, K., additional, von Buren, A. O., additional, Friedrich, C., additional, Treulieb, W., additional, Lindow, C., additional, Kwiecien, R., additional, Ottensmeier, H., additional, Rutkowski, S., additional, Armstrong, C. L., additional, Phillips, P. C., additional, Lustig, R. A., additional, Stamos, C., additional, Li, Y., additional, Belasco, J., additional, Minturn, J. E., additional, Fisher, M. J., additional, Heinks-Maldonado, T., additional, Wingeier, K., additional, Lory, V., additional, Schafer, C., additional, Studer, M., additional, Steinlin, M., additional, Leibundgut, K., additional, de Ruiter, M., additional, Schouten, N., additional, Greidanus, J., additional, Grootenhuis, M., additional, Oosterlaan, J., additional, A, A. L.-V., additional, Grill, J., additional, Puget, S., additional, Sainte-Rose, C., additional, Dufour, C., additional, Kieffer, V., additional, Dellatolas, G., additional, -Shkedi, E. B., additional, Ben Arush, M. W., additional, Kaplinsky, H., additional, Ash, S., additional, Goshen, Y., additional, Yaniv, I., additional, Cohen, I. J., additional, Levy, J. M., additional, Tello, T., additional, Lu, X., additional, Gao, D., additional, Wilkening, G., additional, Donson, A., additional, Foreman, N., additional, Liu, A., additional, Korzeniewska, J., additional, Baginska, B. D., additional, Perek, D., additional, Staccioli, S., additional, Chieffo, D., additional, Petrarca, M., additional, Moxon-Emre, I., additional, Taylor, M., additional, Bouffet, E., additional, Malkin, D., additional, Hawkins, C., additional, Scantlebury, N., additional, Mabbott, D., additional, Cunningham, T., additional, Piscione, J., additional, Igoe, D., additional, Orfus, M., additional, Bartels, U., additional, Laughlin, S., additional, Tabori, U., additional, Hardy, K., additional, Carlson-Green, B., additional, Conklin, H., additional, Dockstader, C., additional, Wang, F., additional, Bostan, S., additional, Liu, F., additional, Zou, P., additional, Conklin, H. M., additional, Mulhern, R. K., additional, Butler, R. W., additional, Ogg, R. J., additional, Diver, T., additional, Manley, P., additional, Kieran, M., additional, Chordas, C., additional, Liptak, C., additional, Delaney, B., additional, Brand, S., additional, and Rey-Casserly, C., additional

Published
2012
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18. QUALITY OF LIFE/AFTERCARE

Author

Rednam, S., primary, Scheurer, M., additional, Adesina, A., additional, Lau, C., additional, Okcu, M., additional, Deatrick, J., additional, Ogle, S., additional, Fisher, M., additional, Barakat, L., additional, Hardie, T., additional, Li, Y., additional, Ginsberg, J., additional, Ben-Arush, M., additional, Krivoy, E., additional, Rosenkranz, R., additional, Peretz-Nahum, M., additional, Brown, R. J., additional, Love, J., additional, Warburton, D., additional, McBride, W. H., additional, Bluml, S., additional, Mueller, S., additional, Sear, K., additional, Hills, N., additional, Chettout, N., additional, Afghani, S., additional, Lew, L., additional, Tolentino, E., additional, Haas-Kogan, D., additional, Fullerton, H., additional, Reddick, W., additional, Palmer, S., additional, Glass, J., additional, Ogg, R., additional, Gajjar, A., additional, Omar, A., additional, Perkins, S., additional, Shinohara, E., additional, Spoljaric, D., additional, Isenberg, J., additional, Whittington, M., additional, Hauff, M., additional, King, A., additional, Litzelman, K., additional, Barker, E., additional, Catrine, K., additional, Puccetti, D., additional, Possin, P., additional, Witt, W., additional, Mallucci, C., additional, Kumar, R., additional, Pizer, B., additional, Williams, D., additional, Pettorini, B., additional, Piscione, J., additional, Bouffet, E., additional, Shams, I., additional, Kulkarni, A., additional, Remes, T., additional, Harila-Saari, A., additional, Suo-Palosaari, M., additional, Arikoski, P., additional, Riikonen, P., additional, Sutela, A., additional, Koskenkorva, P., additional, Ojaniemi, M., additional, Rantala, H., additional, Campen, C. J., additional, Ashby, D., additional, Fisher, P. G., additional, Monje, M., additional, Kulkarni, A. V., additional, Nakamura, H., additional, Makino, K., additional, Yano, S., additional, Kuratsu, J.-i., additional, Jadrijevic-Cvrlje, F., additional, Batinica, M., additional, Toledano, H., additional, Hoffman, T., additional, Ezer-Cohen, Y., additional, Michowiz, S., additional, Yaniv, I., additional, Cohen, I. J., additional, Adler, I., additional, Mindel, S., additional, Gopalakrishnamoorthy, M., additional, Saunders, D., additional, Gaze, M., additional, Spoudeas, H., additional, Kieffer, V., additional, Dellatolas, G., additional, Chevignard, M., additional, Puget, S., additional, Dhermain, F., additional, Grill, J., additional, Dufour, C., additional, Muir, R., additional, Hunter, A., additional, Latchman, A., additional, de Camargo, O., additional, Scheinemann, K., additional, Dhir, N., additional, Zaky, W., additional, Zomorodian, T., additional, Wong, K., additional, Dhall, G., additional, Macy, M., additional, Lauro, C., additional, Zeitler, P., additional, Foreman, N., additional, Liu, A., additional, Chocholous, M., additional, Dodier, P., additional, Peyrl, A., additional, Dieckmann, K., additional, Hausler, G., additional, Slavc, I., additional, Avula, S., additional, Garlick, D., additional, Armstrong, G., additional, Kawashima, T., additional, Leisenring, W., additional, Stovall, M., additional, Sklar, C., additional, Robison, L., additional, Samaan, C., additional, Duckworth, J., additional, Greenberg-Kushnir, N., additional, Freedman, S., additional, Eshel, R., additional, Zverling, N., additional, Elhasid, R., additional, Dvir, R., additional, Yalon, M., additional, Constantini, S., additional, Wilne, S., additional, Liu, J.-F., additional, Trusler, J., additional, Lundsell, S., additional, Kennedy, C., additional, Clough, L., additional, Dickson, N., additional, Lakhanpaul, M., additional, Baker, M., additional, Dudley, J., additional, Grundy, R., additional, Walker, D., additional, von Hoff, K., additional, Herzog, N., additional, Ottensmeier, H., additional, Grabow, D., additional, Gerber, N. U., additional, Friedrich, C., additional, von Bueren, A. O., additional, Resch, A., additional, Kortmann, R. D., additional, Kaatsch, P., additional, Doerr, H. G., additional, Rutkowski, S., additional, del Bufalo, F., additional, Mastronuzzi, A., additional, Serra, A., additional, de Sio, L., additional, Locatelli, F., additional, Biassoni, V., additional, Leonardi, M., additional, Ajovalasit, D., additional, Riva, D., additional, Vago, C., additional, Usilla, A., additional, Fidani, P., additional, Schiavello, E., additional, Gariboldi, F., additional, Massimino, M., additional, Lober, R., additional, Perrault, S., additional, Partap, S., additional, Edwards, M., additional, Fisher, P., additional, Yeom, K., additional, Salgado, D., additional, Nunes, S., additional, Vinhais, S., additional, Wells, E. M., additional, Seidel, K., additional, Ullrich, N. J., additional, Diller, L., additional, Krull, K. R., additional, Neglia, J., additional, Robison, L. L., additional, Whelan, K., additional, Russell, C. E., additional, Brownstone, D., additional, Kaise, C., additional, Bull, K., additional, Culliford, D., additional, Calaminus, G., additional, Bertin, D., additional, Vallero, S., additional, Romano, E., additional, Basso, M. E., additional, Biasin, E., additional, Fagioli, F., additional, Ziara, K., additional, L'Hotta, A., additional, Williams, A., additional, Thede, R., additional, Moore, K., additional, James, A., additional, Bjorn, E., additional, Franzen, P., additional, Haag, A., additional, Lax, A.-K., additional, Moreno, I., additional, Obeid, J., additional, Timmons, B. W., additional, Iwata, W., additional, Wagner, S., additional, Lai, J.-S., additional, Waddell, K., additional, VanLeeuwen, S., additional, Newmark, M., additional, Noonan, J., additional, O'Connell, K., additional, Urban, M., additional, Yount, S., additional, Goldman, S., additional, Igoe, D., additional, Cunningham, T., additional, Orfus, M., additional, Mabbott, D., additional, Liptak, C., additional, Manley, P., additional, Recklitis, C., additional, Zhang, P., additional, Shaikh, F., additional, Narang, I., additional, Matsumoto, K., additional, Yamasaki, K., additional, Okada, K., additional, Fujisaki, H., additional, Osugi, Y., additional, Hara, J., additional, Phipps, K., additional, Gumley, D., additional, Jacques, T., additional, Hargrave, D., additional, Michalski, A., additional, Chordas, C., additional, Chi, S., additional, Robison, N., additional, Bandopadhayay, P., additional, Marcus, K., additional, Zimmerman, M. A., additional, Goumnerova, L., additional, Kieran, M., additional, Brand, S., additional, Brinkman, T., additional, Delaney, B., additional, Diver, T., additional, Rey, C., additional, Madden, J. R., additional, Hemenway, M. S., additional, Dorneman, L., additional, Stiller, D., additional, Liu, A. K., additional, Foreman, N. K., additional, Vibhakar, R., additional, Mitchell, M., additional, Hemenway, M., additional, Madden, J., additional, Ryan, M., additional, O'Kane, R., additional, Picton, S., additional, Kenny, T., additional, Stiller, C., additional, Chumas, P., additional, Bendel, A., additional, Patterson, R., additional, Barrera, M., additional, Schulte, F., additional, Bartels, U., additional, Janzen, L., additional, Johnston, D., additional, Cataudella, D., additional, Chung, J., additional, Sung, L., additional, Hancock, K., additional, Hukin, J., additional, Zelcer, S., additional, Brandon, S., additional, Montour-Proulx, I., additional, Strother, D., additional, Cooksey, R., additional, Bowers, D., additional, Gargan, L., additional, Gode, A., additional, Klesse, L., additional, Oden, J., additional, Vega, G., additional, Sala, F., additional, Nuzzi, D., additional, Mulino, M., additional, Masotto, B., additional, Mazza, C., additional, Bricolo, A., additional, Gerosa, M., additional, Tong, M., additional, Laughlin, S., additional, Mackie, S., additional, Taylor, L., additional, Sharpe, G., additional, Al-Salihi, O., additional, and Nicolin, G., additional

Published
2012
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39. New textures in children's book art.

Author

Krull, K. and Lodge, S.

Subjects
*CHILDREN'S literature
Abstract

Presents three examples of children's books which incorporate a unique, textured art style which brings new form and dimension to the printed page. Faith Ringgold's `A Quilt Tells a Story'; Sally Mavor's `A Fabric-Relief Fable; Debra Frasier's `Connecting Cultures Through Collage.'

Published
1991

41. Children's books.

Author

Krull, K.

Subjects
*BOOKS
Abstract

Reviews `The Diane Goode Book of American Folk Tales & Songs,' collected by Ann Durell and illustrated by Diane Goode.

Published
1990

42. Children's books.

Author

Krull, K.

Subjects
*CHILDREN'S literature
Abstract

Reviews `The Chalk Doll' by Charlotte Pomerantz and `Tell Me A Story, Mama' by Angela Johnson. INSET: Bookshelf (additional titles of interest)..

Published
1989

43. On the day you were born.

Author

Krull, K.

Subjects
ON the Day You Were Born (Book)
Abstract

Reviews the book `On the Day You Were Born,' by Debra Frasier.

Published
1992

44. Characterization of Patient Activation among Childhood Cancer Survivors in the St. Jude Lifetime Cohort Study (SJLIFE).

Author

Ware ME, De La Cruz A, Dong Q, Shelton K, Brinkman TM, Huang IC, Webster R, Potter B, Krull K, Mirzaei S, Ehrhardt M, Hudson MM, Armstrong G, and Ness K

Abstract

Background: Patient activation describes a willingness to take action to manage health and is associated with health outcomes. The purpose of this study was to characterize patient activation and its association with psychological outcomes and health behaviors in childhood cancer survivors., Methods: Participants were from the St. Jude Lifetime Cohort Study (SJLIFE). Activation levels (1-4, 4 = highest activation) were measured with the Patient Activation Measure (PAM). Psychological outcomes and health behaviors were obtained via self-report. Cognitive function was assessed by trained examiners. ANOVA or chi-squared tests were utilized to assess group-level differences in activation. Multivariable regression models were used to assess associations between PAM scores and outcomes of interest., Results: Among 2708 survivors and 303 controls, more survivors endorsed lower activation levels than the controls (11.3 vs. 4.7% in level 1) and fewer survivors endorsed the highest level of activation than the controls (45.3 vs. 61.5% in level 4). Not endorsing depression (OR: 2.37, 95% CI 1.87-2.99), anxiety (OR: 2.21, 95% CI 1.73-2.83), and somatization symptoms (OR: 1.99, 95% CI 1.59-2.50), general fear (OR: 1.45, 95% CI 1.23-1.71) and body-focused (OR: 2.21, 95% CI 1.83-2.66), cancer-related worry, and physical (OR: 2.57, 95% CI 2.06-3.20) and mental (OR: 2.08, 95% CI 1.72-2.52) HRQOL was associated with higher levels of activation. Lower activation was associated with not meeting physical activity guidelines (OR: 2.07, 95% CI 1.53-2.80)., Conclusions: Survivors endorsed lower activation levels than peers. Interventions to improve physical and psychological health outcomes could leverage these results to identify survivors who benefit from support in patient activation.

Published
2024
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45. Race and Ethnicity, Socioeconomic Factors, and Epigenetic Age Acceleration in Survivors of Childhood Cancer.

Author

Chen C, Plonski NM, Dong Q, Song N, Zhang X, Parikh HM, Finch ER, Easton J, Mulder HL, Walker E, Neale G, Pan Y, Li Q, Zhang J, Krull K, Robison LL, Armstrong GT, Yasui Y, Ness KK, Hudson MM, Wang H, Huang IC, and Wang Z

Subjects
Humans, Female, Male, Cross-Sectional Studies, Child, Neoplasms genetics, Neoplasms ethnology, Adolescent, White People statistics & numerical data, White People genetics, Black or African American statistics & numerical data, Black or African American genetics, DNA Methylation, Adult, Ethnicity statistics & numerical data, Social Determinants of Health statistics & numerical data, Cancer Survivors statistics & numerical data, Socioeconomic Factors, Epigenesis, Genetic
Abstract

Importance: Current research in epigenetic age acceleration (EAA) is limited to non-Hispanic White individuals. It is imperative to improve inclusivity by considering racial and ethnic minorities in EAA research., Objective: To compare non-Hispanic Black with non-Hispanic White survivors of childhood cancer by examining the associations of EAA with cancer treatment exposures, potential racial and ethnic disparity in EAA, and mediating roles of social determinants of health (SDOH)., Design, Setting, and Participants: In this cross-sectional study, participants were from the St Jude Lifetime Cohort, which was initiated in 2007 with ongoing follow-up. Eligible participants included non-Hispanic Black and non-Hispanic White survivors of childhood cancer treated at St Jude Children's Research Hospital between 1962 and 2012 who had DNA methylation data. Data analysis was conducted from February 2023 to May 2024., Exposure: Three treatment exposures for childhood cancer (chest radiotherapy, alkylating agents, and epipodophyllotoxin)., Main Outcomes and Measures: DNA methylation was generated from peripheral blood mononuclear cell-derived DNA. EAA was calculated as residuals from regressing Levine or Horvath epigenetic age on chronological age. SDOH included educational attainment, annual personal income, and the socioeconomic area deprivation index (ADI). General linear models evaluated cross-sectional associations of EAA with race and ethnicity (non-Hispanic Black and non-Hispanic White) and/or SDOH, adjusting for sex, body mass index, smoking, and cancer treatments. Adjusted least square means (ALSM) of EAA were calculated for group comparisons. Mediation analysis treated SDOH as mediators with average causal mediation effect (ACME) calculated for the association of EAA with race and ethnicity., Results: Among a total of 1706 survivors including 230 non-Hispanic Black survivors (median [IQR] age at diagnosis, 9.5 [4.3-14.3] years; 103 male [44.8%] and 127 female [55.2%]) and 1476 non-Hispanic White survivors (median [IQR] age at diagnosis, 9.3 [3.9-14.6] years; 766 male [51.9%] and 710 female [48.1%]), EAA was significantly greater among non-Hispanic Black survivors (ALSM = 1.41; 95% CI, 0.66 to 2.16) than non-Hispanic White survivors (ALSM = 0.47; 95% CI, 0.12 to 0.81). Among non-Hispanic Black survivors, EAA was significantly increased among those exposed to chest radiotherapy (ALSM = 2.82; 95% CI, 1.37 to 4.26) vs those unexposed (ALSM = 0.46; 95% CI, -0.60 to 1.51), among those exposed to alkylating agents (ALSM = 2.33; 95% CI, 1.21 to 3.45) vs those unexposed (ALSM = 0.95; 95% CI, -0.38 to 2.27), and among those exposed to epipodophyllotoxins (ALSM = 2.83; 95% CI, 1.27 to 4.40) vs those unexposed (ALSM = 0.44; 95% CI, -0.52 to 1.40). The association of EAA with epipodophyllotoxins differed by race and ethnicity (β for non-Hispanic Black survivors, 2.39 years; 95% CI, 0.74 to 4.04 years; β for non-Hispanic White survivors, 0.68; 95% CI, 0.05 to 1.31 years) and the difference was significant (1.77 years; 95% CI, 0.01 to 3.53 years; P for interaction = .049). Racial and ethnic disparities in EAA were mediated by educational attainment (

Published
2024
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46. Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study.

Author

van der Plas E, Darji H, Srivastava DK, Schapiro M, Jeffe D, Perkins S, Howell R, Leisenring W, Armstrong GT, Oeffinger K, Krull K, Edelstein K, and Hayashi RJ

Subjects
Humans, Female, Male, Case-Control Studies, Adult, Risk Factors, Cross-Sectional Studies, Child, Young Adult, Adolescent, Anxiety psychology, Anxiety epidemiology, Anxiety etiology, Quality of Life, Cancer Survivors psychology, Rhabdomyosarcoma psychology, Psychological Distress
Abstract

Background: Prevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well-established., Methods: Participants in this cross-sectional, case-control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.5 [6.6] years; n = 706 siblings, 57.2% female; mean age, 32.8,[7.9] years) completed measures of neurocognition, emotional distress, and health-related quality of life (HRQOL). Multivariable logistic regression models identified treatments, health behaviors, and chronic conditions associated with impairment., Results: Relative to siblings, more survivors reported neurocognitive impairment (task efficiency: 21.1% vs. 13.7%, emotional regulation: 16.7% vs. 11.0%, memory: 19.3% vs. 15.1%), elevated emotional distress (somatic distress: 12.9% vs. 4.7%, anxiety: 11.7% vs. 5.9%, depression: 22.8% vs. 16.9%) and poorer HRQOL (physical functioning: 11.1% vs. 2.8%, role functioning due to physical problems: 16.8% vs. 8.2%, pain: 17.5% vs. 10.0%, vitality: 22.3% vs. 13.8%, social functioning: 14.4% vs. 6.8%, emotional functioning: 17.1% vs. 10.6%). Cranial radiation increased risk for impaired task efficiency (odds ratio [OR], 2.30; 95% confidence interval [CI], 1.14-4.63), whereas chest and pelvic radiation predicted increased risk of physical functioning (OR, 2.68; 95% CI, 1.16-6.21 and OR, 3.44; 95% CI, 1.70-6.95, respectively). Smoking was associated with impaired task efficiency (OR, 2.06; 95% CI, 1.14-3.70), memory (OR, 2.23; 95% CI, 1.26-3.95), anxiety (OR, 2.71; 95% CI, 1.36-5.41) and depression (OR, 1.77; 95% CI, 1.01-3.11). Neurologic conditions increased risk of anxiety (OR, 2.30; 95% CI, 1.04-5.10), and hearing conditions increased risk of depression (OR, 1.79; 95% CI, 1.05-3.03). Neurologic and hearing conditions, respectively, were associated with impaired memory (OR, 2.44; 95% CI, 1.20-4.95 and OR, 1.87; 95% CI, 1.05-3.35) and poor health perception (OR, 2.62; 95% CI, 1.62-1.28 and OR, 2.33; 95% CI, 1.34-4.06)., Conclusions: RMS survivors are at significant risk for poor psychological outcomes. Advancing therapies for local control, smoking cessation, and managing chronic medical conditions may mitigate poor outcomes following RMS., (© 2024 American Cancer Society.)

Published
2024
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47. Financial hardship among siblings of long-term survivors of childhood cancer: A Childhood Cancer Survivor Study report.

Author

Ohlsen TJD, Wang H, Buchbinder D, Huang IC, Desai AD, Zheng Z, Kirchhoff AC, Park ER, Krull K, Conti RM, Yasui Y, Leisenring W, Armstrong GT, Yabroff KR, Nathan PC, and Chow EJ

Subjects
Adult, Humans, Child, Female, Siblings, Financial Stress epidemiology, Cost of Illness, Survivors, Surveys and Questionnaires, Cancer Survivors, Neoplasms epidemiology, Neoplasms therapy
Abstract

Background: Siblings of children with cancer may experience adverse household economic consequences, but their financial outcomes in adulthood are unknown., Methods: A total of 880 siblings (aged 18-64 years) of adult-aged childhood cancer survivors were surveyed to estimate the prevalence of financial hardship by three established domains (behavioral, material, and psychological). For individual financial hardship items matching the contemporaneous National Health Interview Survey or Behavioral Risk Factor Surveillance System, siblings were compared with the general population by calculating adjusted prevalence odds ratios (ORs) to sample-weighted responses. Multivariable logistic regression models examined associations between sibling characteristics and each hardship domain and between sibling hardship and survivors' cancer/treatment characteristics., Results: Behavioral, material, and psychological hardship was reported by 24%, 35%, and 28%, respectively. Compared with national survey respondents, siblings were more likely to report worries about medical bills (OR, 1.14; 95% confidence interval [CI], 1.06-1.22), difficulty affording nutritious foods (OR, 1.79; 95% CI, 1.54-2.07), and forgoing needed medical care (OR, 1.38; 95% CI, 1.10-1.73), prescription medications (OR, 2.52; 95% CI, 1.99-3.20), and dental care (OR, 1.34; 95% CI, 1.15-1.57) because of cost. Sibling characteristics associated with reporting financial hardship in one or more domains included female sex, older age, chronic health conditions, lower income, not having health insurance, high out-of-pocket medical expenditures, and nonmedical/nonhome debt. No survivor cancer/treatment characteristics were associated with sibling financial hardship., Conclusions: Adult siblings of childhood cancer survivors were more likely to experience financial hardship compared with the general population. Childhood cancer may adversely affect entire households, with potentially lasting implications., (© 2023 American Cancer Society.)

Published
2024
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48. Mechanisms of sleep disturbances in long-term cancer survivors: a childhood cancer survivor study report.

Author

Daniel LC, Wang H, Brinkman TM, Ruble K, Zhou ES, Palesh O, Stremler R, Howell R, Mulrooney DA, Crabtree VM, Mostoufi-Moab S, Oeffinger K, Neglia J, Yasui Y, Armstrong GT, and Krull K

Subjects
Humans, Child, Female, Adult, Male, Quality of Life psychology, Chronic Disease, Sleep, Cancer Survivors, Neoplasms therapy, Sleep Wake Disorders complications, Sleep Wake Disorders epidemiology, Sleep Wake Disorders psychology
Abstract

Background: Sleep problems following childhood cancer treatment may persist into adulthood, exacerbating cancer-related late effects and putting survivors at risk for poor physical and psychosocial functioning. This study examines sleep in long-term survivors and their siblings to identify risk factors and disease correlates., Methods: Childhood cancer survivors (≥5 years from diagnosis; n = 12 340; 51.5% female; mean [SD] age = 39.4 [9.6] years) and siblings (n = 2395; 57.1% female; age = 44.6 [10.5] years) participating in the Childhood Cancer Survivor Study completed the Pittsburgh Sleep Quality Index (PSQI). Multivariable Poisson-error generalized estimating equation compared prevalence of binary sleep outcomes between survivors and siblings and evaluated cancer history and chronic health conditions (CHC) for associations with sleep outcomes, adjusting for age (at diagnosis and current), sex, race/ethnicity, and body mass index., Results: Survivors were more likely to report clinically elevated composite PSQI scores (>5; 45.1% vs 40.0%, adjusted prevalence ratio [PR] = 1.20, 95% CI = 1.13 to 1.27), symptoms of insomnia (38.8% vs 32.0%, PR = 1.26, 95% CI = 1.18 to 1.35), snoring (18.0% vs 17.4%, PR = 1.11, 95% CI = 1.01 to 1.23), and sleep medication use (13.2% vs 11.5%, PR = 1.28, 95% CI = 1.12 to 1.45) compared with siblings. Within cancer survivors, PSQI scores were similar across diagnoses. Anthracycline exposure (PR = 1.13, 95% CI = 1.03 to 1.25), abdominal radiation (PR = 1.16, 95% CI = 1.04 to 1.29), and increasing CHC burden were associated with elevated PSQI scores (PRs = 1.21-1.48)., Conclusions: Among survivors, sleep problems were more closely related to CHC than diagnosis or treatment history, although longitudinal research is needed to determine the direction of this association. Frequent sleep-promoting medication use suggests interest in managing sleep problems; behavioral sleep intervention is advised for long-term management., (© The Author(s) 2024. Published by Oxford University Press.)

Published
2024
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49. The ENGAGE study: a 3-arm randomized hybrid type 1 effectiveness and implementation study of an in-home, collaborative PCP model of remote telegenetic services to increase uptake of cancer genetic services in childhood cancer survivors.

Author

Henderson TO, Allen MA, Mim R, Egleston B, Fleisher L, Elkin E, Oeffinger K, Krull K, Ofidis D, Mcleod B, Griffin H, Wood E, Cacioppo C, Weinberg M, Brown S, Howe S, McDonald A, Vukadinovich C, Alston S, Rinehart D, Armstrong GT, and Bradbury AR

Subjects
Humans, Child, Genetic Testing, Cancer Survivors, Neoplasms genetics
Abstract

Background: Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and screening guidelines for genetic carriers. Access to genetic services is limited in many places, which leaves many genetic carriers unidentified and at risk for late diagnosis of cancers and poor outcomes. This poses a problem for childhood cancer survivors, as this is a population with an increased risk for subsequent malignant neoplasms (SMN) due to cancer therapy or inherited cancer predisposition. The ENGaging and Activating cancer survivors in Genetic services (ENGAGE) study evaluates the effectiveness of an in-home, collaborative PCP model of remote telegenetic services to increase uptake of cancer genetic testing in childhood cancer survivors compared to usual care options for genetic testing., Methods: The ENGAGE study is a 3-arm randomized hybrid type 1 effectiveness and implementation study within the Childhood Cancer Survivor Study population which tests a clinical intervention while gathering information on its delivery during the effectiveness trial and its potential for future implementation among 360 participants. Participants are randomized into three arms. Those randomized to Arm A receive genetic services via videoconferencing, those in Arm B receive these services by phone, and those randomized to Arm C will receive usual care services., Discussion: With many barriers to accessing genetic services, innovative delivery models are needed to address this gap and increase uptake of genetic services. The ENGAGE study evaluates the effectiveness of an adapted model of remote delivery of genetic services to increase the uptake of recommended genetic testing in childhood cancer survivors. This study assesses the uptake in remote genetic services and identify barriers to uptake to inform future recommendations and a theoretically-informed process evaluation which can inform modifications to enhance dissemination beyond this study population and to realize the benefits of precision medicine., Trial Registration: This protocol was registered at clinicaltrials.gov (NCT04455698) on July 2, 2020., (© 2024. The Author(s).)

Published
2024
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50. Epigenetic Age in Peripheral Blood Among Children, Adolescent, and Adult Survivors of Childhood Cancer.

Author

Plonski NM, Chen C, Dong Q, Qin N, Song N, Parikh HM, Shelton K, Finch ER, Easton J, Mulder H, Zhang J, Neale G, Walker E, Wang H, Krull K, Ness KK, Hudson MM, Robison LL, Li Q, Williams A, and Wang Z

Subjects
Male, Middle Aged, Humans, Child, Adolescent, Aged, Adult, Female, Cross-Sectional Studies, Survivors, Epigenesis, Genetic, Obesity epidemiology, Neoplasms epidemiology, Neoplasms genetics, Cancer Survivors
Abstract

Importance: Certain cancer therapies are risk factors for epigenetic age acceleration (EAA) among survivors of childhood cancer, and EAA is associated with chronic health conditions (CHCs). However, small numbers of younger survivors (aged <20 years) previously evaluated have limited the ability to calculate EAA among this age group., Objective: To evaluate the change rate of epigenetic age (EA) and EAA in younger compared with older survivors and the possible association of EAA with early-onset obesity (aged <20 years), severity/burden of CHCs, and late mortality (>5 years from cancer diagnosis)., Design, Setting, and Participants: Study participants were from the St Jude Lifetime Cohort, initiated in 2007 with ongoing follow-up. The present study was conducted from April 17, 2022, to March 23, 2023. Survivors in this cohort of European ancestry with DNA methylation data were included. Cross-sectional annual changes in EA and EAA were compared across 5 different chronologic age groups: age 0 to 9 (children), 10 to 19 (adolescents), 20 to 34 (younger adults), 35 to 49 (middle-aged adults), and greater than or equal to 50 (older adults) years. Logistic regression evaluated the association between EAA and early-onset obesity or severity/burden of CHCs. Cox proportional hazards regression assessed the association between EAA and late mortality., Main Outcomes and Measures: Early-onset obesity, severity/burden of CHCs (graded using the Common Terminology Criteria for Adverse Events (grade 1, mild; 2, moderate; 3, severe/disabling; 4, life-threatening) and were combined into high vs low severity/burden based on frequency and grade), and late mortality were the outcomes based on follow-up until April 2020. Expanded DNA methylation profiling increased the number of survivors younger than 20 years (n = 690). Epigenetic age was calculated primarily using the Levine clock, and EAA was derived from least squares regression of EA against chronologic age and was standardized to a z score (Levine EEA)., Results: Among 2846 participants (median age, 30.3 [IQR, 9.3-41.5] years; 53% males), the cross-sectional annual change in EA&#95;Levine was higher in children (1.63 years) and adolescents (1.14 years), and the adjusted least-squares mean of Levine EEA was lower in children (-0.22 years) and older adults (-1.70 years). Each 1-SD increase in Levine EEA was associated with increased risk of developing early-onset obesity (odds ratio [OR], 1.46; 95% CI, 1.19-1.78), high severity/burden of CHCs (OR, 1.13; 95% CI, 1.03-1.24), and late mortality (hazard ratio, 1.75; 95% CI, 1.35-2.26)., Conclusions and Relevance: The findings of this study suggest that EAA measured in children and adolescent survivors of childhood cancer is associated with early-onset obesity, severity/burden of all CHCs, and late mortality. Evaluating EAA may help identify survivors of childhood cancer at increased risk for early-onset obesity, morbidity in general, and mortality.

Published
2023
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