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Biopsies are important for diagnosis and prognosis. However, the challenge is to hit the target and obtain representative tissue sample from heterogeneous organs. Bioimpedance can be utilized in needle guidance since many abnormalities change the electrical properties of tissue. Because the biopsy instrument gathers tissue even 1-3 cm forward from the needle tip during sample intake it is important that the measurement is performed in front of the needle, and tissues next to or behind the needle tip do not affect the measurement. We created an enhanced Bioimpedance Probe (BIP) Biopsy needle, which measures impedance in real-time from the very tip of the needle. Our eccentric geometry optimizes the spatial resolution providing 98% of measurement sensitivity on the needle facet and in front of it. Based on simulations, the improvement in spatial resolution from the previously published design is over 90 percentage points. Our enhanced BIP Biopsy needle was tested in different tissues in vivo and the results are promising. [ABSTRACT FROM AUTHOR]