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3. Response of eosinophilic fasciitis associated with Waldenström macroglobulinemia to rituximab

Author

Kromer, Christian, Matzke, Silke S, Bleckmann, Annalen, Overbeck, Tobias, Lippert, Undine, Schön, Michael P, and Mössner, Rotraut

Subjects
biologic, localized scleroderma, rituximab, Shulman's syndrome
Abstract

Eosinophilic fasciitis (EF) and generalized morphea (GM) are rare and difficult-to-treat sclerosing skin diseases which may occur in association with hematologic disorders. We present a 66-year-old man with EF and associated Waldenström macroglobulinemia who received combination therapy with rituximab (375mg/m2 every other week, gradually extended to every eight weeks), prednisolone (1.25-30mg/d), and methotrexate (7.5-15mg/w). Three months after rituximab initiation, his skin condition improved steadily accompanied by a significant improvement in joint mobility with only mild and transitory flares (observation period: 59 months under treatment with rituximab). To date, there are five case reports on rituximab treatment of EF/GM with an association to hypergammaglobulinemia in three of those cases. Therapy effected significant improvement in four patients. Our case adds to the hitherto limited evidence that rituximab may be a promising therapeutic strategy for EF/GM in association with hypergammaglobulinemia.

Published
2021

12. Ganzkörper‐Blaulichtbestrahlung zur Behandlung der atopischen Dermatitis: eine randomisierte, placebokontrollierte klinische Studie (AD‐Blue)

Author

Buhl, Timo, primary, Santibanez Santana, Marisol, additional, Forkel, Susann, additional, Kromer, Christian, additional, Seidel, Julia, additional, Möbs, Christian, additional, Pfützner, Wolfgang, additional, Pfeiffer, Sebastian, additional, Laubach, Hans‐Joachim, additional, Boehncke, Wolf‐Henning, additional, Liebmann, Joerg, additional, Born, Matthias, additional, and Schön, Michael Peter, additional

Published
2023
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16. Full‐body blue light irradiation as treatment for atopic dermatitis: a randomized sham‐controlled clinical trial (AD‐Blue).

Author

Buhl, Timo, Santibanez Santana, Marisol, Forkel, Susann, Kromer, Christian, Seidel, Julia, Möbs, Christian, Pfützner, Wolfgang, Pfeiffer, Sebastian, Laubach, Hans‐Joachim, Boehncke, Wolf‐Henning, Liebmann, Joerg, Born, Matthias, and Schön, Michael Peter

Abstract

Summary: Background: Visible blue light (wavelength 400–495 nm) is a promising new treatment option for both psoriasis and atopic dermatitis (AD). Whilst previous clinical trials featured various devices and blue light at a variety of wavelengths, none of these interventions were challenged in objective clinical criteria. Patients and Methods: Eighty‐seven patients diagnosed with AD were enrolled in AD‐Blue, an international, prospective, double‐blinded, three‐armed (415 nm vs. 450 nm vs. sham control), randomized trial designed to investigate the safety and efficacy of prototype full‐body blue light devices. Results: Full‐body irradiation with 450 nm blue light but not 415 nm had a significant impact on itch (Itch‐VAS, –1.6 ± 2.3; p = 0.023 vs. sham irradiation). PO‐SCORAD values also decreased significantly in response to irradiation at 415 nm (–11.5 ± 18.4; p = 0.028 vs. sham irradiation). None of the other outcome measures (EASI, SCORAD, IGA, DLQI) changed significantly. No safety signals were observed. Evaluation of skin transcriptomes, cytokine levels in serum, and ELISpots from peripheral blood mononuclear cells isolated from a subset of patients revealed moderate decreases in IL‐31 in response to irradiation with blue light. Conclusions: Despite its favorable safety profile and moderate reductions in itch and IL‐31 levels, full‐body blue light irradiation did not lead to an amelioration of any of the objective measures of AD. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Checkpoint blockade and BRAF/MEK therapy in the therapeutic setting improved the overall survival after sentinel node biopsy: A retrospective study comparing patients with primary care between 1998‐2009 and 2010‐2017.

Author

Kretschmer, Lutz, Bernhard, Leonie, Leha, Andreas, Kromer, Christian, Julius, Katharina, Schön, Michael P., and Schnabel, Viktor

Subjects
SENTINEL lymph nodes, OVERALL survival, BRAF genes, LOG-rank test, PRIMARY care, MELANOMA
Abstract

Immunotherapies using checkpoint blockade and BRAF/MEK therapies have improved overall survival (OS) in patients with unresectable melanoma metastases. In this retrospective study, we aimed to demonstrate the resulting increase in melanoma‐specific survival (MSS) and OS after the excision of primary melanomas (≥1 mm thick) and sentinel lymph node (SN) biopsy (SNB). Using Kaplan‐Meier estimates and Cox models, we compared two consecutive cohorts. Patients in cohort 1 (N = 518) underwent SNB between 1998 and 2009, and patients in cohort 2 (N = 460) between 2010 and 2017, when checkpoint blockade and BRAF/(MEK) inhibition became available for the treatment of unresectable relapses. The median follow‐up times were 120 and 73 months, respectively. While recurrence‐free and distant metastasis‐free survival rates remained very similar, MSS and OS increased in favor of cohort 2. The estimated 5‐year OS rate of SN‐positive patients increased by 14.3% (78.5% vs 64.2%, logrank test: P =.005). The MSS benefit was significant even with low SN tumor burden (metastasis diameter < 1 mm). On multivariate analyses, the risk‐reduction in favor of cohort 2 was significant in the total population and in the SN‐negative and SN‐positive subgroups. In SN‐positive patients, besides the availability of modern therapies, SN metastasis diameter and ulceration were independent factors of MSS and OS. Treatment of unresectable melanoma recurrences with modern drug therapies results in significantly higher survival rates in a population with SNB. The survival benefit measured from primary melanoma affects both the SN‐positive and SN‐negative subpopulations. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Patientenpräferenzen bei Hidradenitis suppurativa (APProach‐HS): ein “Discrete‐Choice”‐Experiment

Author

Faverio, Kristin, primary, Peitsch, Wiebke K., additional, Görig, Tatiana, additional, Schneider‐Burrus, Sylke, additional, Benzel, Friderike, additional, Goebeler, Matthias, additional, Schummer, Patrick, additional, Badran, Alaa, additional, Schaarschmidt, Marthe‐Lisa, additional, Harth, Wolfgang, additional, Mössner, Rotraut, additional, and Kromer, Christian, additional

Published
2022
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23. Patient Preferences in Hidradenitis Suppurativa (APProach‐HS): a discrete choice experiment

Author

Faverio, Kristin, primary, Peitsch, Wiebke K., additional, Görig, Tatiana, additional, Schneider‐Burrus, Sylke, additional, Benzel, Friderike, additional, Goebeler, Matthias, additional, Schummer, Patrick, additional, Badran, Alaa, additional, Schaarschmidt, Marthe‐Lisa, additional, Harth, Wolfgang, additional, Mössner, Rotraut, additional, and Kromer, Christian, additional

Published
2022
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26. Experimental investigation of the oil jet heat transfer on meshing spur gears

Author

Ayan, Emre, Kromer, Christian, Schwitzke, Corina, and Bauer, Hans-Jörg

Subjects
ddc:620, Engineering & allied operations
Abstract

Designing an adequate cooling system for a high-speed high-power gearbox of a geared turbofan requires a thorough understanding of the cooling capabilities of the utilized oil jet impingement. An experimental setup is employed to determine the heat transfer coefficient on gear teeth in various non-meshing and meshing configurations, which incorporate inclined jets with varying distances between the impingement and the meshing zones. The direction of heat transfer is inverted in the experiments to allow for a feasible setup with the rotating gears, where impinging oil jets heat the hollow instrumented gear as its inner surface is cooled via air jet impingement. Measurements with varying oil volume flow rates and rotational speeds are carried out. The losses are analyzed to enable an isolated investigation of the heat transfer between the oil and the gear via measured temperatures on the gear teeth. Heat transfer coefficients are compared at the lower rotational speed with relatively small meshing losses. The meshing in the experimental setup does not have a significant influence on the mean heat transfer coefficient. The spatial distribution of the heat transfer coefficient is slightly affected by the meshing teeth as the distribution gets more uniform with decreasing distance between the impingement and meshing zones.

Published
2022

27. Experimental Investigation of the Oil Jet Heat Transfer for an Aero Engine Gearbox

Author

Kromer, Christian, Ayan, Emre, Schwitzke, Corina, and Bauer, Hans-Jörg

Subjects
superposition, experimental data, heat transfer, liquid impingement cooling, ddc:620, Engineering & allied operations
Abstract

Geared turbofan engines have the potential to propel future civil aircraft engines more efficiently. A planetary gearbox between the low-pressure turbine and the fan enables the operation of both components at their respective optimum rotational speeds. This makes it possible to achieve higher bypass ratios and thus a better propulsion efficiency. A crucial part of the planetary gearbox design is the cooling and lubrication of the gears. Sufficient heat removal from the gear tooth flanks is necessary to ensure reliable operation without the risk of gear failure through pitting or scoring. Fast rotating and highly loaded gears are cooled with impinging oil jets according to current design guidelines. This impingement cooling process comprises a complex, multi-phase flow with heat transfer. Previous experimental, numerical and analytical investigations have shown that the cooling process depends both on the highly unsteady liquid flow dynamics and on the heat conduction in the oil film formed on the gear tooth flank. In this study, the gear is replaced by a cylinder in order to be able to study the impingement cooling on a rotating surface without the influence of unsteady flow phenomena. A hollow cylinder is instrumented with 42 thermocouples across the surface, which are all connected to a telemetry system. A single oil jet is directed radially onto the outer cylinder surface. The measured temperatures are subsequently corrected using a new algorithm to reduce systematic measurement errors without distorting the data. The corrected temperatures are used to calculate the Nusselt number distribution across the cylinder surface by means of a finite element analysis. A parameter study is performed to identify the influence of the parameters oil flow rate, oil viscosity and rotational speed of the cylinder on the heat transfer. The fundamental results of the present study enable a better understanding of the heat transfer on impingement cooled cylinders and spur gears.

Published
2022
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32. Melanocytic Nevi In Sentinel Lymph Nodes - Association With Cutaneous Nevi And Clinical Relevance In Patients With Cutaneous Melanomas

Author

Kretschmer, Lutz, primary, Schnabel, Viktor, additional, Kromer, Christian, additional, Bauer-Büntzel, Christoph, additional, Richter, Annika, additional, Bremmer, Felix, additional, Kück, Fabian, additional, Julius, Katharina, additional, Mitteldorf, Chirsitna, additional, and Schön, Michael P., additional

Published
2021
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36. Influenza Vaccination in Psoriatic Patients - Epidemiology and Patient Perceptions: A German Multicenter Study (Vac-Pso)

Author

Kromer, Christian, Wellmann, Phoebe, Siemer, Ralf, Klein, Selina, Mohr, Johannes, Pinter, Andreas, Wilsmann-Theis, Dagmar Irmgard, and Mößner, Rotraut

Subjects
ddc:000, ddc:610, ddc:510
Abstract

The risk of developing severe complications from an influenza virus infection is increased in patients with chronic inflammatory diseases such as psoriasis (PsO) and atopic dermatitis (AD). However, low influenza vaccination rates have been reported. The aim of this study was to determine vaccination rates in PsO compared to AD patients and explore patient perceptions of vaccination. A multicenter cross-sectional study was performed in 327 and 98 adult patients with PsO and AD, respectively. Data on vaccination, patient and disease characteristics, comorbidity, and patient perceptions was collected with a questionnaire. Medical records and vaccination certificates were reviewed. A total of 49.8% of PsO and 32.7% of AD patients were vaccinated at some point, while in season 2018/2019, 30.9% and 13.3% received an influenza vaccination, respectively. There were 96.6% and 77.6% of PsO and AD patients who had an indication for influenza vaccination due to age, immunosuppressive therapy, comorbidity, occupation, and/or pregnancy. Multivariate regression analysis revealed higher age (p < 0.001) and a history of bronchitis (p = 0.023) as significant predictors of influenza vaccination in PsO patients. Considering that most patients had an indication for influenza vaccination, the rate of vaccinated patients was inadequately low.

Published
2021

47. Skin lesions of face and scalp – Classification by a market-approved convolutional neural network in comparison with 64 dermatologists

Author

Haenssle, Holger Andreas, primary, Winkler, Julia Katharina, additional, Fink, Christine, additional, Toberer, Ferdinand, additional, Enk, Alexander, additional, Stolz, Wilhelm, additional, Deinlein, Teresa, additional, Hofmann-Wellenhof, Rainer, additional, Kittler, Harald, additional, Tschandl, Philipp, additional, Rosendahl, Cliff, additional, Lallas, Aimilios, additional, Blum, Andreas, additional, Abassi, Mohamed Souhayel, additional, Thomas, Luc, additional, Tromme, Isabelle, additional, Rosenberger, Albert, additional, Bachelerie, Marie, additional, Bajaj, Sonali, additional, Balcere, Alise, additional, Baricault, Sophie, additional, Barthaux, Clément, additional, Beckenbauer, Yvonne, additional, Bertlich, Ines, additional, Bouthenet, Marie-France, additional, Brassat, Sophie, additional, Buck, Philipp Marcel, additional, Buder-Bakhaya, Kristina, additional, Cappelletti, Maria-Letizia, additional, Chabbert, Cécile, additional, De Labarthe, Julie, additional, DeCoster, Eveline, additional, Dobler, Michèle, additional, Dumon, Daphnée, additional, Emmert, Steffen, additional, Gachon-Buffet, Julie, additional, Gusarov, Mikhail, additional, Hartmann, Franziska, additional, Hartmann, Julia, additional, Herrmann, Anke, additional, Hoorens, Isabelle, additional, Hulstaert, Eva, additional, Karls, Raimonds, additional, Kolonte, Andreea, additional, Kromer, Christian, additional, Le Blanc Vasseux, Céline, additional, Levy-Roy, Annabelle, additional, Majenka, Pawel, additional, Marc, Marine, additional, Bourret, Veronique Martin, additional, Michelet-Brunacci, Nadège, additional, Mitteldorf, Christina, additional, Paroissien, Jean, additional, Picard, Camille, additional, Plise, Diana, additional, Reymann, Valérie, additional, Ribeaudeau, Fabrice, additional, Richez, Pauline, additional, Plaine, Hélène Roche, additional, Salik, Deborah, additional, Sattler, Elke, additional, Schäfer, Sarah, additional, Schneiderbauer, Roland, additional, Secchi, Thierry, additional, Talour, Karen, additional, Trennheuser, Lukas, additional, Wald, Alexander, additional, Wölbing, Priscila, additional, and Zukervar, Pascale, additional

Published
2021
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48. Design of low-power fast VCSEL drivers for high-density links in 90-nm SOI CMOS

Author

Sialm, Gion, Kromer, Christian, Ellinger, Frank, Morf, Thomas, Erni, Daniel, and Jackel, Heinz

Subjects
Silicon-on-isolator -- Design and construction, Complementary metal oxide semiconductors -- Design and construction, Lasers -- Usage, Laser, Business, Computers, Electronics, Electronics and electrical industries
Abstract

The continuous decrease of the supply voltage to 1 V and below in CMOS makes the design of laser drivers a challenging task. Hence, a detailed comparison of three basic driver architectures, namely, common source (CS), CS with source degeneration, and source follower (SF) is presented using transistor models including short channel effects. Based on this comparison, two power-optimized driver topologies are implemented in a 90-nm silicon-on-insulator CMOS technology. The SF driver features a bandwidth of 18 GHz on a 50-[ohm] load. The required chip area is only 140 [micro]m x 140 [micro]m, which is very beneficial for high-density short-distance optical interconnects. This allows a data rate of 12.5 Gb/s at a bit error ratio of less than [10.sup.-12] to be achieved even with a 10-Gb/s oxide confined vertical-cavity surface-emitting laser (VCSEL). The power consumption is 27 mW. The drivers were optimized for maximal eye opening by applying a fast and accurate VCSEL model. Index Terms--Common source (CS), modeling, optical interconnects, parasitics, source follower (SF), vertical-cavity surface-emitting laser (VCSEL).

Published
2006

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