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3. Circle of Willis integrity in acute middle cerebral artery occlusion: does the posterior communicating artery matter?

Author

Sadeh-Gonik, Udi, Budylev, Anatoly, Krivitzky, David, Molad, Jeremy, Halevi, Hen, Jonas-Kimchi, Tali, Yashar, Hila, Assayag, Einor Ben, and Seyman, Estelle

Subjects
INTRACRANIAL aneurysm surgery, INTRACRANIAL aneurysms, CIRCLE of Willis, SURVIVAL rate, ANTERIOR cerebral artery, MULTIPLE regression analysis, BLOOD vessels, COMPUTED tomography, ENDOVASCULAR surgery, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, MULTIVARIATE analysis, DECISION making in clinical medicine, CEREBRAL arteries, LONGITUDINAL method, STATISTICS, INFARCTION, THROMBECTOMY, STROKE, CONFIDENCE intervals, COLLATERAL circulation
Abstract

Background Collateral circulation is an important determinant of outcome in people with acute ischemic stroke due to large vessel occlusion (LVO). Objective To explore the impact of the circle of Willis (CW) anatomical characteristics ipsilateral to the occlusion site, particularly the posterior communicating artery (PComA) and the A1-portion of the anterior cerebral artery (A1-ACA), on stroke outcomes in a cohort of patients with LVO and middle cerebral artery (MCA) occlusion, undergoing endovascular thrombectomy (EVT). Methods This is a retrospective cohort study performed in a comprehensive tertiary stroke center. The study population consisted of consecutive patients with LVO with proximal MCA occlusion (M1) between June 2016 and April 2021, undergoing EVT. Demographic, clinical, and imaging information was extracted from patient files. Patency and diameters of ipsilateral A1-ACA and PComA were manually measured on admission CT angiography images in the core laboratory. Results One hundred and five patients with LVO comprised the study cohort, mean age 72.3 years, 43.8% were male, mean National Institutes of Health Stroke Scale score at admission 15.2. The cohort was grouped according to CW vessel characteristics. On univariate analysis, a well-developed PComA was associated with lower rates of hemorrhagic transformation (1.8% vs 14.3%, P=0.01) and a trend towards lower mortality rates (8.9% vs 20.4%, P=0.08). On multivariable regression analysis a well-developed PComA emerged as an independent predictor for survival (aOR=0.09, 95% CI 0.01 to 0.4 for survival at discharge, P=0.009, aOR=0.22, 95% CI 0.05 to 0.8 for survival at 90 days, P=0.02). Conclusions In a cohort of patients with LVO due to M1 occlusion undergoing EVT, a well-developed PComA was associated with significantly lower hemorrhagic transformation rates, a trend towards better functional outcomes, and independently predicted survival. Larger studies are needed to understand the differential effect of CW collateral conduits on stroke outcome and evaluate the practicality of incorporating such factors in the clinical decision-making process prior to EVT. [ABSTRACT FROM AUTHOR] more...

Published
2024
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4. Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate

Author

Diaz, George A, Krivitzky, Lauren S, Mokhtarani, Masoud, Rhead, William, Bartley, James, Feigenbaum, Annette, Longo, Nicola, Berquist, William, Berry, Susan A, Gallagher, Renata, Lichter‐Konecki, Uta, Bartholomew, Dennis, Harding, Cary O, Cederbaum, Stephen, McCandless, Shawn E, Smith, Wendy, Vockley, Gerald, A., Stephen, Korson, Mark S, Kronn, David, Zori, Roberto, Merritt, J Lawrence, Nagamani, Sandesh CS, Mauney, Joseph, LeMons, Cynthia, Dickinson, Klara, Moors, Tristen L, Coakley, Dion F, Scharschmidt, Bruce F, and Lee, Brendan more...

Subjects
Clinical Research, Clinical Trials and Supportive Activities, Neurosciences, Brain Disorders, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adolescent, Adult, Ammonia, Child, Cross-Over Studies, Double-Blind Method, Female, Glutamine, Glycerol, Humans, Male, Middle Aged, Neuropsychological Tests, Phenylbutyrates, Urea Cycle Disorders, Inborn, Young Adult, Medical Biochemistry and Metabolomics, Clinical Sciences, Immunology, Gastroenterology & Hepatology
Abstract

UnlabelledGlycerol phenylbutyrate is under development for treatment of urea cycle disorders (UCDs), rare inherited metabolic disorders manifested by hyperammonemia and neurological impairment. We report the results of a pivotal Phase 3, randomized, double-blind, crossover trial comparing ammonia control, assessed as 24-hour area under the curve (NH3 -AUC0-24hr ), and pharmacokinetics during treatment with glycerol phenylbutyrate versus sodium phenylbutyrate (NaPBA) in adult UCD patients and the combined results of four studies involving short- and long-term glycerol phenylbutyrate treatment of UCD patients ages 6 and above. Glycerol phenylbutyrate was noninferior to NaPBA with respect to ammonia control in the pivotal study, with mean (standard deviation, SD) NH3 -AUC0-24hr of 866 (661) versus 977 (865) μmol·h/L for glycerol phenylbutyrate and NaPBA, respectively. Among 65 adult and pediatric patients completing three similarly designed short-term comparisons of glycerol phenylbutyrate versus NaPBA, NH3 -AUC0-24hr was directionally lower on glycerol phenylbutyrate in each study, similar among all subgroups, and significantly lower (P < 0.05) in the pooled analysis, as was plasma glutamine. The 24-hour ammonia profiles were consistent with the slow-release behavior of glycerol phenylbutyrate and better overnight ammonia control. During 12 months of open-label glycerol phenylbutyrate treatment, average ammonia was normal in adult and pediatric patients and executive function among pediatric patients, including behavioral regulation, goal setting, planning, and self-monitoring, was significantly improved.ConclusionGlycerol phenylbutyrate exhibits favorable pharmacokinetics and ammonia control relative to NaPBA in UCD patients, and long-term glycerol phenylbutyrate treatment in pediatric UCD patients was associated with improved executive function (ClinicalTrials.gov NCT00551200, NCT00947544, NCT00992459, NCT00947297). (HEPATOLOGY 2012). more...

Published
2013

5. Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: Six years of case-referent surveillance

Author

Abbas, Firas, Abdelmoumni, Abdelhakim, Hilliquin, Pascal, Requeda, Elisabeth, Adoue, Daniel, Brassat, David, Agard, Christian, Masseau, Agathe, Aladjidi, Nathalie, Clet, Johanna, Fernandes, Helder, Lemasson, Gwendal, Perel, Yves, Raymond, Isabelle, Richer, Olivier, Vital, Anne, Allain-Launay, Emma, Bru, Marie, Nicolino, Marc, Thomas, Caroline, Altman, Jean-Jacques, Amsallem, Daniel, Aras, Nazmiye, Boukari, Latifato, Dubrel, Marie, Fain, Olivier, Letellier, Edouard, Lucidarme, Nadine, Mekinian, Arsène, Morin, Anne-Sophie, Stirnemann, Jérôme, Atlan, Catherine, Audry, Dominique, Augustin, Jérôme, Bakir, Redouane, Bartolucci, Pablo, Chevalier, Xavier, Godeau, Bertrand, Guillaud, Constance, Khellaf, Mehdi, Limal, Nicolas, Lousteau, Valentine, Mahevas, Matthieu, Méliksetyan, Gayane, Michel, Marc, Roumier, Mathilde, Bayart, Sophie, Bonnet, Fabrice, Decaux, Olivier, Bekherraz, Amine, Brihaye, Benoit, Dachez, Roger, Daugas, Eric, Hayem, Gilles, Meyer, Olivier, Papo, Thomas, Pasqualoni, Elisa, Sacre, Karim, Travert, Florence, Bellon, Hélène, Beltrand, Jacques, Lefrere, François, Simon, Albane, Benhamou, Pierre-Yves, Benveniste, Olivier, Bolgert, Francis, Costedoat-Chalumeau, Nathalie, De Paz, Raphael, Demeret, Sophie, Fautrel, Bruno, Jacqueminet, Sophie, Louapre, Céline, Maillart, Elizabeth, Morel, Nathalie, Papeix, Caroline, Rigabert, Julie, Bensaid, Philippe, Berger, Claire, Berquin, Patrick, Le Moing, Anne-Gaëlle, Berroir, Stéphane, Besson, Gérard, Boutte, Célia, Casez, Olivier, Bonnotte, Bernard, Audia, Sylvain, Bossu-Estour, Cécile, Bourgarit, Anne, Dupuy, Alain, Keshmandt, Homa, Bourre, Bertrand, Brac, Aude, Perrin, Agnès, Pondarré, Corinne, Villar-Fimbel, Sylvie, Bruckert, Isabelle, Cosson, Anne, Magy-Bertrand, Nadine, Tisserand, Guillaume, Camu, William, Carlander, Bertrand, Morales, Raul Juntas, Cances, Claude, Pasquet, Marlene, Castilla Lievre, Maria Angela, Chabroux, Stephanie, Charif, Mamoud, Chatelus, Emmanuel, Sibilia, Jean, Chevrant-Breton, Jacqueline, Clavel, Sylvaine, Bille-Turc, Françoise, Cohen, Jacques, Courcoux, Marie France, Leverger, Guy, Machet, Laurent, Cuisset, Jean-Marie, Cony-Makhoul, Pascale, Darsy, Paul, Favre, Sandrine, Giraud, Pierrick, Leitenschenck, Laurence, Monteiro, Irène, Morati, Chafika, DeSeze, Jérôme, Dinulescu, Monica, Dhaoui, Taher, Dommange-Romero, Florence, Drevard, Elisabeth, Dupuis, Clémentine, Dumuis, Marie-Laure, Durand, Jean-Marc, Farad, Samia, Lecomte, Pierre, Pierre, Peggy, Fouyssac, Fanny, Gaudin, Philippe, Gautier, Alain, Gellen-Dautremer, Justine, Jarrin, Irène, Richette, Pascal, Georget, Emilie, Gras, Pierre, Moreau, Thibault, Giraud, Eric, Hacini, Maya, Mayer, Anne, Guillaumat, Cécile, Guillaume, Séverine, Guitton, Corinne, Kone-Paut, Isabelle, Marsaud, Céline, Rossi, Linda, Guyot, Marie-Hélène, Hassler, Patrick, Heimfert, Claude, Heinzlef, Olivier, Hillion, Brigitte, Hocquelet, Catherine, Husson, Helene, Ichai, Pierre, Jeziorski, Eric, Deslandre, Chantal Job, Le Guern, Véronique, Kamenov, Kamen, Kerlan, Véronique, Lemoine, Philippe, Misery, Laurent, Pan-Petesch, Brigitte, Krivitzky, Alain, Labauge, Pierre, Rodier, Michel, Lacade, Chadi, Razafimahefa, Berthe, Lachgar, Karim, Larmarau, Marie-Pierre, Leblanc, Thierry, Lebrun-Frenay, Christine, Lefèbvre, Patrick, Lejoyeux, Philippe, Leske, Charles, Ly, Kim, Magy, Laurent, Mansuy, Sylvie, Marechaud, Richard, Martin Negrier, Marie-Laure, Sole, Guilhem, Maupetit, Jean, Mazingue, Françoise, Mochon, Stéphanie, Moktar, Blidi, Morcamp, Donald, Morlet-Barla, Nathalie, Nicolas, Guillaume, Pautot, Vivien, Pellier, Isabelle, Verret, Jean-Luc, Outteryck, Olivier, Vermersch, Patrick, Pallot-Prades, Beatrice, Paquet, Jean Michel, Puechal, Xavier, Sortais, Annie, Pelletier, Jean, Rico, Audrey, Pez, Dominique, Stankoff, Bruno, Quittet, Philippe, Rémy, Claude, Roba, Eléna, Rosario, Hélène, Roudaut, Nathalie, Sonnet, Emmanuel, Ruel, Michel, Sebban, Samuel, Schaepelynck, Pauline, Simonin, Marie-Jeanne, Vial, Christophe, Viallard, Jean-Francois, Ladedan, Isabelle, Zenone, Thierry, Grimaldi-Bensouda, Lamiae, Rossignol, Michel, Koné-Paut, Isabelle, Courcoux, Marie-France, Viallard, Jean-François, Bourgault-Villada, Isabelle, Breart, Gerard, and Abenhaim, Lucien more...

Published
2017
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13. Recent Advances in Neuropsychological Outcomes and Intervention in Pediatric Stroke

Author

Lauren S. Krivitzky, Robyn Westmacott, Richard Boada, Leigh Sepeta, Lauren Reppert, and Christine Mrakotsky

Subjects
Advanced and Specialized Nursing, Stroke, Executive Function, Cognition, Stroke Rehabilitation, Humans, Attention, Neurology (clinical), Neuropsychological Tests, Cardiology and Cardiovascular Medicine, Child, Language
Abstract

Over the past 15 years, there have been significant advances in the treatment of acute and chronic medical consequences of stroke in childhood. Given high rates of survival in pediatric stroke, practitioners are tasked with treating the ongoing motor and neuropsychological sequelae in patients over the course of their development. This article provides a review of the current literature on neuropsychological outcomes in pediatric stroke, including intelligence, academics, language, visual-spatial skills, attention, executive functions, memory, and psychosocial function. Recent developments in functional neuroimaging are discussed, with a particular focus on language outcomes. We further review the current research on cognitive and behavioral rehabilitation and introduce intervention models in pediatric stroke. In the final section, we discuss future directions for clinical practice and research in pediatric stroke. more...

Published
2022

14. Children with perinatal stroke are at increased risk for autism spectrum disorder: Prevalence and co-occurring conditions within a clinically followed sample

Author

Rebecca Ichord, Evelyn K. Shih, Lauren Krivitzky, and Taralee Hamner

Subjects
medicine.medical_specialty, Autism Spectrum Disorder, Sample (statistics), Neuropsychological Tests, behavioral disciplines and activities, Arts and Humanities (miscellaneous), Co occurring, Intellectual Disability, mental disorders, Prevalence, Developmental and Educational Psychology, medicine, Perinatal stroke, Humans, Child, Psychiatry, Retrospective Studies, Language Disorders, medicine.disease, Mental health, Stroke, Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, Increased risk, Autism spectrum disorder, Child, Preschool, Autism, Psychology
Abstract

Children with perinatal stroke are at increased risk for developmental language disorders, learning difficulties, and other mental health conditions. However to date, autism (ASD) prevalence in this group has not been reported. Given that early identification of ASD is essential to promoting optimal outcomes, our goal was to establish prevalence of ASD in children with perinatal stroke.A prospectively enrolled, single-center stroke registry maintained at our institution since 2005 was queried for all potentially eligible patients with a history of perinatal stroke. Information regarding stroke features, ASD diagnosis/concern, intellectual disability/global developmental delay, cerebral palsy/hemiparesis, epilepsy, and language disorder were collected via retrospective chart review from electronic health records.311 children were identified, of which 201 complete records were analyzed. Twenty-three cases were formally diagnosed with ASD (11.4%). First concerns were noted in toddlerhood (Mage = 2.66 years), yet the average age of diagnosis was 6.26 years. Children with ASD were more likely to have earlier diagnoses of intellectual disability/global developmental delay or a mixed receptive-expressive language disorder (Children with perinatal stroke have an increased prevalence of ASD (11.4%) than in the general population. ASD concerns arise at a similar age as the general population, yet ASD is diagnosed almost two years later than the general population and 3.60 years after first concerns present. Co-occurring neurological conditions are common. Clinicians must be aware of increased prevalence and implement screening as part of routine care for all pediatric patients with perinatal stroke. more...

Published
2021
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21. Establishing a consortium for the study of rare diseases: The Urea Cycle Disorders Consortium

Author

Seminara, Jennifer, Tuchman, Mendel, Krivitzky, Lauren, Krischer, Jeffrey, Lee, Hye-Seung, LeMons, Cynthia, Baumgartner, Matthias, Cederbaum, Stephen, Diaz, George A., Feigenbaum, Annette, Gallagher, Renata C., Harding, Cary O., Kerr, Douglas S., Lanpher, Brendan, Lee, Brendan, Lichter-Konecki, Uta, McCandless, Shawn E., Merritt, J. Lawrence, Oster-Granite, Mary Lou, Seashore, Margretta R., Stricker, Tamar, Summar, Marshall, Waisbren, Susan, Yudkoff, Marc, and Batshaw, Mark L. more...

Published
2010
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23. Tenofovir DF/emtricitabine and efavirenz combination therapy for HIV infection in patients treated for tuberculosis: the ANRS 129 BKVIR trial

Author

Lortholary, Olivier, Roussillon, Caroline, Boucherie, Céline, Padoin, Christophe, Chaix, Marie-Laure, Breton, Guillaume, Rami, Agathe, Veziris, Nicolas, Patey, Olivier, Caumes, Eric, May, Thierry, Molina, Jean-Michel, Robert, Jérome, Tod, Michel, Fagard, Catherine, Chêne, Geneviève, Aumaître, H., Borsato, F., Malet, M., Médus, M., Moreau, L., Neuville, S., Saada, M., Abgrall, S., Ahoudji, D., Balmard, L., Bentata, M., Bouchaud, O., Boudribila, A., Cailhol, J., Dhote, R., Djebbar, R., Gros, H., Honoré, P., Huynh, T., Krivitzky, A., Mansouri, R., Pizzocolo, C., Rouges, F., Viot, E., Amar, B., Bantsimba, J., Dellion, S., Patey, O., Richier, L., Dupon, M., Dutronc, H., Neau, D., Ragnaud, J. M., Raymond, I., Boucly, S., Gailhoustet, L., Lortholary, O., Maignan, A., Touam, F., Viard, J. P., Bergmann, J. F., Boulanger, E., Delcey, V., Diemer, M., Durel, A., Jouade, F., Parrinello, M., Rami, A., Sellier, P., Brazille, P., Leclerc, C., Welker, Y., Bernard, L., Berthé, H., Perronne, C., Salomon, J., de Truchis, P., Bolliot, C., Couzigou, C., Derradji, O., Escaut, L., Teicher, E., Vittecoq, D., Chakvetadze, C., Fontaine, C., LʼYavanc, T., Maresca, A., Pialoux, G., Slama, L., Tuna, L., Bornarel, D., Boué, F., Chassaing, A., Chaiba-Berroukeche, L., Chambrin, V., Delavalle, A. M., Galanaud, P., Levy, A., Pignon, C., Bonnet, D., Ecobichon, J. L., Fournier, I., Fraquiero, G., Gerbe, J., Gervais, A., Guiyedi, V., Iordache, L., Joly, V., Klutse, P., Laurichesse, J. J., Leport, C., Onanga, M., Pahlaval, G., Phung, B. C., Ralaimazava, P., Yeni, P., Almasi, F., Basler, M., Benammar, N., Brunes, A., Guérin, C., Guillevin, L., Meddour, R., Salmon, D., Spiridon, G., Tahi, T., Bloch, M., Ferreira, C., Mahe, I., Manceron, V., Minozzi, C., Mortier, E., Simonpoli, A. M., Vinceneux, P., Zeng Ai, F., Chesnel, C., Dominguez, S., Jouve, P., Lascaux-Cametz, A. S., Lelièvre, J. D., Levy, Y., Melica, G., Sobel, A., Bentaleb, N., Blondin-Diop, A., Bonmarchand, M., Bossi, P., Brancon, C., Breton, G., Bricaire, F., Caby, F., Canestri, A., Clavel, C., Edeb, N., Herson, S., Iguertsira, M., Katlama, C., Kouadio, H., Lagarde, P., Lopez, J. L., Marguet, F., Martinez, V., Remidi, H., Simon, A., Souchon, J. F., Valantin, M. A., Bollens, D., Girard, P. M., Lagneau, J. L., Lefebvre, B., Mouchotte, R., Ouazene, Z., Sebire, M., Theveny-Christiany, A., Valin, N., Bourgarit, A., de Castro, N., Delgado, J., Ferret, S., Lascoux-Combe, C., Molina, J. M., Parlier, S., Pavie, J., Pintado, C., Ponscarme, D., Rachline, A., Sereni, D., Taulera, O., de Verdiere, C., Vincent, F., Bernard, N., Bonarek, M., Bonnet, F., Delaune, J., Lacoste, D., Louis, I., Malvy, D., Mercier, P., Morlat, P., Pertusa, M. C., Schottey, M., Chanteloube, N., Eden, A., Le Moing, V., Makilson, A., de Boever, C. Merle, Reynes, J., Turrière, C., Tramoni, C., Vidal, M., Anavena, C., Billaud, E., Biron, C., Bonnet, B., Bouchez, J., Boutoille, D., Brosseau, D., Brunct, C., Colas, M., Feuillebois, N., Hüe, H., Launay, E., le Houssine, P. Morineau, Raffi, F., Reliquet, V., Cua, E., Dellamonica, P., Durant, J., Rahelinirina, V., Arvieux, C., Chapplain, J. M., Fily, F., Labbay, E., Michelet, C., Morin, F., Peaucelle, C., Revest, M., Ratajczak, M., Souala, F., Tattevin, P., Thomas, R., Alvarez, M., Balsarin, F., Bonnet, E., Busato, F., Cuzin, L., Marche, D., Marchou, B., Massip, P., Obadia, M., Porte, L., Aissi, E., Ajana, F., Alcaraz, I., Baclet, V., Dubus, S., Gérard, Y., Guerroumi, H., Huleux, T., Lahouste, A., Marien, M. C., Melliez, H., Mouton, Y., Pennel, M. P., Valette, M., Viget, N., Yazdanpanah, Y., Bevilacqua, S., Boyer, L., Lecompte, T., Letranchant, L., May, T., Rabaud, C., Thomas, L., Vancon, R., Wassoumbou, S., Abboud, P., Borsa-Lebas, F., Caron, F., Debab, Y., Etienne, M., Faucon, M., Gueit, I., Brouqui, P., Mokhtari, S., Moreau, J., Schlojsers, M., Vandergheynst, E., Chousterman, M., Delacroix-Szmania, I., El Harrar, B., Garrait, V., Joannes, S., Luquet-Besson, I., Mouchet, M., Richier, L., Stevens, A. Blase, Dupont, C., Maresca, A. Freire, Greffe, S., Hanslik, T., Landi, B., Leporrier, J., Rouveix, E., Toth, K., El Mansouf, L., Khuong-Josses, M. A., Méchali, D., Le Besnerais, J. Phalip, Taverne, B., Barclay, F., Fain, O., Flexor, G., Stirnemann, J., Tassi, S., Levast, M., Rogeaux, O., Raffenot, D., Tous, J., Lortholary, O., Bouchaud, O., Chaix, M. L., Chêne, G., Couffin-Cadiergues, S., Dupon, M., Fagard, C., Joly, V., Launay, O., Molina, J. M., Robert, J., Roussillon, C., Rouzioux, C., Tod, M., Yazdanpanah, Y., Lortholary, O., Breton, G., Caumes, E., May, T., Roussillon, C., Veziris, N., Badets, M., Boucherie, C., Fagard, C., Chêne, G., Roussillon, C., Terras, N., Guérin, C., Altare, F., Bourgarit, A., Carcelain, G., Trylesinski, A., Aubron-Olivier, C., Nguyen, T., and Bennai, Y. more...

Published
2016
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30. Children with perinatal stroke are at increased risk for autism spectrum disorder: Prevalence and co-occurring conditions within a clinically followed sample.

Author

Hamner, Taralee, Shih, Evelyn, Ichord, Rebecca, and Krivitzky, Lauren

Subjects
AUTISM spectrum disorders, NEUROLOGICAL disorders, LANGUAGE disorders, DISABILITY identification, DEVELOPMENTAL delay, INTELLECTUAL disabilities, STROKE
Abstract

Children with perinatal stroke are at increased risk for developmental language disorders, learning difficulties, and other mental health conditions. However to date, autism (ASD) prevalence in this group has not been reported. Given that early identification of ASD is essential to promoting optimal outcomes, our goal was to establish prevalence of ASD in children with perinatal stroke. A prospectively enrolled, single-center stroke registry maintained at our institution since 2005 was queried for all potentially eligible patients with a history of perinatal stroke. Information regarding stroke features, ASD diagnosis/concern, intellectual disability/global developmental delay, cerebral palsy/hemiparesis, epilepsy, and language disorder were collected via retrospective chart review from electronic health records. 311 children were identified, of which 201 complete records were analyzed. Twenty-three cases were formally diagnosed with ASD (11.4%). First concerns were noted in toddlerhood (Mage = 2.66 years), yet the average age of diagnosis was 6.26 years. Children with ASD were more likely to have earlier diagnoses of intellectual disability/global developmental delay or a mixed receptive-expressive language disorder (ps <.001) but did not differ on CP/hemiplegia or epilepsy diagnoses. Risk for ASD increased with accumulating diagnoses. Children with perinatal stroke have an increased prevalence of ASD (11.4%) than in the general population. ASD concerns arise at a similar age as the general population, yet ASD is diagnosed almost two years later than the general population and 3.60 years after first concerns present. Co-occurring neurological conditions are common. Clinicians must be aware of increased prevalence and implement screening as part of routine care for all pediatric patients with perinatal stroke. [ABSTRACT FROM AUTHOR] more...

Published
2022
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31. Role and evolution of viral tropism in patients with advanced HIV disease receiving intensified initial regimen in the ANRS 130 APOLLO trial

Author

Charpentier, Charlotte, Joly, Véronique, Larrouy, Lucile, Fagard, Catherine, Visseaux, Benoit, de Verdière, Nathalie Colin, Raffi, François, Yeni, Patrick, Descamps, Diane, Aumaître, H., Medus, M., Neuville, S., Saada, M., Abgrall, S., Bentata, M., Bouchaud, O., Cailhol, J., Cordel, H., Dhote, R., Gros, H., Honoré-Berlureau, P., Huynh, T., Krivitzky, A., Mansouri, R., Poupard, M., Prendki, V., Radia, D., Rouges, F., Touam, F., Warde, B., de Castro, N., Colin de Verdière, N., Delgado, J., Ferret, S., Gallien, S., Kandel, T., Lafaurie, M., Lagrange, M., Lascoux-Combe, C., Le, D., Molina, J. M., Pavie, J., Pintado, C., Ponscarme, D., Rachline, A., Rozenbaum, W., Sereni, D., Taulera, O., Estavoyer, J. M., Faucher, J. F., Foltzer, A., Hoen, B., Hustache-Mathieu, L., Dupon, M., Dutronc, H., Neau, D., Ragnaud, J. M., Raymond, I., Boucly, S., Lortholary, O., Viard, J. P., Bechara, C., Delfraissy, J. F., Ghosn, J., Goujard, C., Kamouh, W., Môle, M., Quertainmont, Y., Bergmann, J. F., Boulanger, E., Castillo, H., Parrinello, M., Rami, A., Sellier, P., Lepeu, G., Pichancourt, G., Bernard, L., Berthé, H., Clarissou, J., Gory, M., Melchior, J. C., Perronne, C., Stegman, S., de Truchis, P., Derradji, O., Malet, M., Teicher, E., Vittecoq, D., Chakvetadze, C., Fontaine, C., Lukiana, T., Pialloux, G., Slama, L., Bonnet, D., Boucherit, S., El Alami Talbi, N., Fournier, I., Gervais, A., Joly, V., Iordache, L., Laurichesse, J. J., Leport, C., Pahlavan, G., Phung, B. C., Yeni, P., Bennamar, N., Brunet, A., Guillevin, L., Salmon-Ceron, D., Tahi, T., Chesnel, C., Dominguez, S., Jouve, P., Lelièvre, J. D., Levy, Y., Melica, G., Sobel, A., Ben Abdallah, S., Bonmarchand, M., Bricaire, F., Herson, S., Iguertsira, M., Katlama, C., Kouadio, H., Schneider, L., Simon, A., Valantin, M. A., Abel, S., Beaujolais, V., Cabié, A., Liauthaud, B., Pierre François, S., Abgueguen, P., Chennebault, J. M., Loison, J., Pichard, E., Rabier, V., Delaune, J., Louis, I., Morlat, P., Pertusa, M. C., Brunel-Delmas, F., Chiarello, P., Jeanblanc, F., Jourdain, J. J., Livrozet, J. M., Makhloufi, D., Touraine, J. L., Augustin-Normand, C., Bailly, F., Benmakhlouf, N., Brochier, C., Cotte, L., Gueripel, V., Koffi, K., Lack, P., Lebouché, B., Maynard, M., Miailhes, P., Radenne, S., Schlienger, I., Thoirain, V., Trepo, C., Drogoul, M. P., Fabre, G., Faucher, O., Frixon-Marin, V., Gastaut, J. A., Peyrouse, E., Poizot-Martin, I., Jacquet, J. M., Le Facher, G., Merle de Boever, C., Reynes, J., Tramoni, C., Allavena, C., Billaud, E., Biron, C., Bonnet, B., Bouchez, S., Boutoille, D., Brunet-François, C., Hüe, H., Mounoury, O., Raffi, F., Reliquet, V., Aubry, O., Esnault, J. L., Leautez-Nainville, S., Perré, P., Suaud, I., Bréaud, S., Ceppi, C., Dellamonica, P., De Salvador, F., Durant, J., Ferrando, S., Fuzibet, J. G., Leplatois, A., Mondain, V., Perbost, I., Pugliese, P., Rahelinirina, V., Rosenthal, E., Sanderson, F., Vassalo, M., Arvieux, C., Chapplain, J. M., Michelet, C., Ratajczak, M., Revest, M., Souala, F., Tattevin, P., Chéneau, C., Fischer, P., Lang, J. M., Partisani, M., Rey, D., Bastides, F., Besnier, J. M., Le Bret, P., Choutet, P., Dailloux, J. F., Guadagnin, P., Nau, P., Rivalain, J., Soufflet, A., Aïssi, E., Melliez, H., Pavel, S., Mouton, Y., Yazdanpanah, Y., Boyer, L., Burty, C., Letranchant, L., May, T., Wassoumbou, S., Blum, L., Danne, O., Arthus, M. A., Dion, P., Certain, A., Tabuteau, S., Beuscart, A., Agher, N., Frosch, A., Couffin-Cadiergues, S., and Diallo, A. more...

Published
2013
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32. Ont collaboré à cet ouvrage

Author

Asselah, Tarik, primary, Bakchine, Serge, additional, Mouret, Sylvain Balester, additional, Batel, Philippe, additional, Bernard, Jean-Antoine, additional, Blétry, Olivier, additional, Boisaubert, Bernard, additional, Bordenave, Mathieu, additional, Bourdain, Frédéric, additional, Boyer, Nathalie, additional, Brézin, Antoine, additional, Briet, Marie, additional, Brissot, Pierre, additional, Brousse, Christine, additional, Cabane, Jean, additional, Casadevall, Nicole, additional, Chabolle, Frédéric, additional, Chapelle, Olga, additional, Chapron, Charles, additional, Cherin, Patrick, additional, Chopin, Nicolas, additional, Cordier, Bernard, additional, Crenn, Pascal, additional, Berthaud, Jocelyne Crnac, additional, Cudennec, Tristan, additional, Decroix, Jean-Pierre, additional, Delahousse, Michel, additional, Élalamy, Ismail, additional, Foubert, Luc, additional, Gardel, Bérénice, additional, Gepner, Patrick, additional, Girszyn, Nicolas, additional, Godeau, Bertrand, additional, Gompel, Anne, additional, Gourgon, René, additional, Grandpeix, Catherine, additional, Graveleau, Philippe, additional, Grimaldi, André, additional, Grivois, Jean-Philippe, additional, Grünfeld, Jean-Pierre, additional, Guiomard, Alain, additional, Hadoux, Mélissa, additional, Hanslik, Thomas, additional, Hatron, Pierre-Yves, additional, Hausser-Hauw, Chantal, additional, Hervé, Jean-Marie, additional, Houillier, Pascal, additional, Kahn, Jean-Emmanuel, additional, Kettaneh, Adrien, additional, Klein, André, additional, Krivitzky, Alain, additional, Laloum, Laurent, additional, Lebret, Thierry, additional, Lechowski, Laurent, additional, Leport, Jacques, additional, Lugagne, Pierre-Marie, additional, Malek-Chéhire, Nayla, additional, Marcellin, Patrick, additional, Marroun, Ibrahim, additional, Masquet, Christiane, additional, Mathieu, Emmanuel, additional, Matis, Richard, additional, Melchior, Jean-Claude, additional, Melchior, Yves, additional, Moraillon, Maud, additional, Moucari, Rami, additional, Ohresser, Martine, additional, Pedarriosse, Anne-Marie, additional, Philippe, Bruno, additional, Piette, Anne-Marie, additional, Poulain, Jean-Eudes, additional, Querleu, Denis, additional, Rafii, Arash, additional, Robain, Gilberte, additional, Rousset, Hugues, additional, Sananès, Michel, additional, Schaison, Monique, additional, Somogyi, Alexandre, additional, Somogyi-Demerjian, Nathalie, additional, Thomas, Michel, additional, Thomas, Olivier, additional, Tonnel, André-Bernard, additional, Touati, Michelle-Anne, additional, Toupet, Michel, additional, Tricot, Leila, additional, Trotoux, Jacques, additional, Varet, Bruno, additional, Vignes, Stéphane, additional, Vu, Patrick, additional, and Zucman, David, additional more...

Published
2009
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40. Attention and executive functioning profiles in children following perinatal arterial ischemic stroke

Author

Laura Jastrzab, Rebecca Ichord, Lori Billinghurst, Danielle D. Bosenbark, and Lauren Krivitzky

Subjects
medicine.medical_specialty, Perinatal arterial ischemic stroke, Working memory, 05 social sciences, Neuropsychology, Cognition, Neuropsychological battery, Childhood stroke, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Neuropsychology and Physiological Psychology, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, medicine, Normative, 0501 psychology and cognitive sciences, Psychology, Psychiatry, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Perinatal arterial ischemic stroke (PAIS) is a form of childhood stroke; the majority of those affected experience neurologic sequelae, including motor, language and neurocognitive impairments. This study examines the attention and executive functioning (EF) profiles of children following PAIS, as well as the impact of age and sex. In this single-center cross-sectional study, 40 children aged 3 to 16 years (median age 7.2 years; 58% male) who have suffered a PAIS underwent a comprehensive neuropsychological battery to assess attention and EF. Parents completed behavioral questionnaires regarding real-world functioning. Composite scores were calculated for seven attention and EF domains (Attention, Working Memory, Verbal Retrieval, Inhibitory Control, Flexibility/Shifting, Planning/Organization, and Processing Speed). The results for all measured domains of attention and EF are significantly lower in the participants compared to the normative samples (p more...

Published
2016
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41. Brief report: Relationship between performance testing and parent report of attention and executive functioning profiles in children following perinatal arterial ischemic stroke

Author

Rebecca Ichord, Laura Jastrzab, Lori Billinghurst, Danielle D. Bosenbark, and Lauren Krivitzky

Subjects
Male, Pediatrics, medicine.medical_specialty, Adolescent, Neuropsychological Tests, Brain Ischemia, 03 medical and health sciences, Executive Function, 0302 clinical medicine, Surveys and Questionnaires, Developmental and Educational Psychology, Perinatal stroke, medicine, Humans, 0501 psychology and cognitive sciences, Attention, Child, Perinatal arterial ischemic stroke, 05 social sciences, Stroke, Neuropsychology and Physiological Psychology, Cross-Sectional Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Psychology, 030217 neurology & neurosurgery, 050104 developmental & child psychology
Abstract

Children with perinatal arterial ischemic stroke (PAIS) have increased rates of attention and executive functioning (EF) weaknesses. Research in other pediatric disorders has documented poor consistency between parent report of these skills and performance-based measures. We compared these data sources in children with PAIS. Forty full-term (≥37 weeks) children ages 3-16 (median = 7.2 years; 58% male) with PAIS completed neuropsychological testing and composite scores were created for seven attention and EF domains (Processing Speed; Attention; Working Memory; Verbal Retrieval; Inhibitory Control; Flexibility/Shifting; Planning). Parents completed "real-world" functioning questionnaires (ADHD Rating Scale-IV, BRIEF). Correlational analysis were used to compare parent and performance measures. Correlations between ADHD Rating Scale-IV scores and the performance-based Attention and Inhibition composite scores were nonsignificant. Significant negative correlations were found between the BRIEF GEC and performance-based Verbal Retrieval and Processing Speed composites, but remaining GEC/composite comparisons were nonsignificant. Analyses between parent report BRIEF index scores and the corresponding performance-based domain identified one significant negative correlation between the BRIEF Working Memory Index and the Working Memory composite score. While children with PAIS demonstrate difficulties in attention and EF on both parent report and performance measures, little significance was found in comparisons of these two types of measures. There may be several explanations for this dissociation: measures assessing different aspects of the same underlying construct; performance-based measures lacking ecological validity; and parents underestimating/underreporting their child's deficits. Thus, multiple sources of informant and performance data are necessary to make more accurate conclusions about functioning in these domains. more...

Published
2019

43. Executive functioning profiles from the BRIEF across pediatric medical disorders: Age and diagnosis factors

Author

Madison M. Berl, Lauren Krivitzky, Evelyn L. Fisher, and Karin S. Walsh

Subjects
Male, Neurofibromatosis 1, Adolescent, Cross-sectional study, Neuropsychological Tests, Article, 050105 experimental psychology, Executive Function, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Developmental and Educational Psychology, medicine, Humans, Attention deficit hyperactivity disorder, Cognitive Dysfunction, 0501 psychology and cognitive sciences, Child, Ornithine transcarbamylase deficiency, Retrospective Studies, Leukemia, Brain Neoplasms, 05 social sciences, Age Factors, Repeated measures design, Retrospective cohort study, medicine.disease, Executive functions, Ornithine Carbamoyltransferase Deficiency Disease, Cross-Sectional Studies, Neuropsychology and Physiological Psychology, Attention Deficit Disorder with Hyperactivity, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Analysis of variance, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract

The objective of the study was to compare executive functioning (EF) profiles across several pediatric medical conditions and explore the influence of age of diagnosis and evaluation. A retrospective, cross-sectional study of 734 children aged 5 to 18 years was conducted across five medical groups (brain tumor, leukemia [ALL], epilepsy [EPI], neurofibromatosis type 1 [NF1], and ornithine transcarbamylase deficiency [OTC-D]), attention deficit hyperactivity disorder (ADHD) controls, and matched healthy controls. We compared groups across the scales of a parent-completed Behavior Rating Inventory of Executive Functioning (BRIEF) using a repeated measures analysis of variance (ANOVA). Separate ANOVAs were conducted to look at age factors. The results showed that the ADHD group differed from all other groups and had the highest level of reported EF problems. The NF1 and OTC-D groups differed significantly from the healthy comparison group for overall EF problems, while the EPI and cancer groups did not. Working memory was the most elevated scale across medical groups, followed by plan/organize. Children with medical disorders were two to four times more likely than healthy controls to have clinically significant problems in several EF domains. There was a main effect for age at diagnosis and age at evaluation. A subset of children with medical disorders were found to have parent-reported EF difficulties, with particular vulnerability noted in working memory and organizational/planning skills. This has relevance for the development of interventions that may be helpful across disorders. Children with particular diagnoses and earlier age of diagnosis and evaluation had greater reported EF problems. more...

Published
2015
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45. Further progress towards a catalogue of all Arabidopsis genes: analysis of a set of 5000 non-redundant ESTs

Author

Cooke, Richard, Raynal, Monique, Laudié, Michele, Grellet, Françoise, Delseny, Michel, Morris, Peter-Christian, Guerrier, Danièle, Giraudat, Jérôme, Quigley, Françoise, Clabault, Gérard, Li, You-Fang, Mache, Régis, Krivitzky, Micheline, Gy, Isabelle Jean-Jacques, Kreis, Martin, Lecharny, Alain, Parmentier, Yves, Marbach, Jacqueline, Fleck, Jacqueline, Clément, Bernadette, Philipps, Gabriel, Hervé, Christine, Bardet, Claude, Tremousaygue, Dominique, Lescure, Bernard, Lacomme, Christophe, Roby, Dominique, Jourjon, Marie-Françoise, Chabrier, Patrick, Charpenteau, Jean-Louis, Desprez, Thierry, Amselem, Joelle, Chiapello, Helen, and Höfte, Herman more...

Published
1996

47. [Peripartum cardiomyopathy: a case report]

Author

S, Karchmer-Krivitzky, R, Espinosa-Fernández, A, Sánchez-Aranda, M J, LópezRioja, and D, Monzalbo-Núñez

Subjects
Adult, Heart Failure, Ventricular Dysfunction, Left, Pregnancy, Pregnancy Complications, Cardiovascular, Peripartum Period, Humans, Female, Cardiomyopathies, Echocardiography, Transesophageal
Abstract

Peripartum cardiomyopathy also known as cardiomyopathy associated with pregnancy, is rarely a cause of heart failure, it affects pregnant or puerperal women in the first 5 months. Although the first case reported was in 1849, it was recognized until 1930. In 2010 the European Society of Cardiology Working Group on peripartum cardiomyopathy, defined this pathology as an idiopathic cardiomyopathy that affects pregnant women between the third trimester and five months after delivery. Characterized by a left ventricular failure with an ejection fraction of ≤45% and an end-diastolic dimension ≥2.7 cm/m2 , in absence of an identifiable cause of heart failure.We report a case of a 39-year-old patient, diagnosed with a peripartum cardiomyopathy in the early puerperium, characterized by hypertension, tachycardia, dyspnea and oxygen desaturation. The transesophageal echocardiogram reported heart failure, a hypokinetic left ventricle and a ventricular failure with an ejection fraction40%. We could not identify an other cause to justify heart failure. Multidisciplinary management was administered successfully.The importance of this article relies in the fact that eripartum cardiomyopathy has a high morbidity and mortality. The impact of this pathology is unknow in our country. Here we establish and discuss the multidisciplinary management held in our hospital with this specific patient in order to improve the prognosis on future occasions. more...

Published
2018

48. Novel Centrifugal Compressor Architecture for Wide-Range Operation: A Feasibility Assessment

Author

Louis M. Larosiliere and Eric M. Krivitzky

Subjects
Computer science, Range (aeronautics), Centrifugal compressor, Architecture, Gas compressor, Automotive engineering
Abstract

Turbocharger compressor performance plays a critical role in the ability of advanced Internal Combustion Engines (ICE) to meet the required fuel economy and drivability targets. Increased use of exhaust gas recirculation (EGR) combined with engine downsizing has pushed compressor operation towards — and often beyond — the stability boundary. However, certain applications and market trends require that no compromise be made to the rated power conditions. This has led to a highly disparate set of requirements for a single turbocharger system resulting in much of the compressor map, including the highest-efficiency area, unused or underutilized. A large percentage of the drive cycle is spent operating the compressor at low flow rates and low pressure ratios, near the compressor surge line, in an area of low efficiency. Compromises in efficiency in critical regions of engine operation result from balancing the disparate requirements. A current approach to meeting these disparate flow targets is the use of two turbochargers in series that are sized such that the operating compressor efficiency is markedly improved. This paper introduces a novel, hybrid single-stage compressor architecture which aerodynamically matches the functions of a series sequential dual turbocharger compression system. The use of a variable flow rate inducer bypass can provide a throttleable work-adding alternate flowpath for high-flow conditions, essentially emulating an efficient large compressor when the bypass is open and a small compressor when the bypass is closed. Using the variable bypass, the low-flow performance improves through an aerodynamically regulated inducer that is tailored to this flow regime. An engineering feasibility assessment supported by CFD, vector diagram analysis, and structural FEA suggest a substantial potential for improved performance across a wide flow range with this novel architecture. more...

Published
2017
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50. Switchable dual-port casing treatment scheme for an enhanced turbocharger compressor operating range

Author

Eric M. Krivitzky, Lingqian Hu, M-C Lai, H Q Sun, Juan Zhang, Ce Yang, Dave R. Hanna, and Louis M. Larosiliere

Subjects
Engineering, business.industry, Mechanical Engineering, Centrifugal compressor, Aerospace Engineering, Port (computer networking), Automotive engineering, Diesel fuel, Range (aeronautics), Gasoline, business, Casing, Gas compressor, Marine engineering, Turbocharger
Abstract

For both diesel and gasoline internal-combustion engines, stringent emissions regulations and fuel economy requirements have significantly intensified the demand on the turbocharger compressor operating flow range with high efficiency levels. To address these needs, the ongoing research and development effort has been focused on advanced turbocharger technologies for a high efficiency and a wide operating range. In this paper, a research effort is reported to enhance further the classic ported shroud or recirculating casing treatment with the addition of two switchable ports along the impeller shroud, which allows an augmented high-speed choke flow range without sacrificing the surge margin and efficiency. Impeller aerodynamic blade design considerations for exploiting this new dual-port casing treatment concept are discussed. Flow bench test results demonstrate that the underlying concepts of the new dual-port casing treatment implemented with a recently developed advanced centrifugal compressor impeller lead to 12% extra flow capacity at the rated speed over the same compressor with a conventional single-port recirculating casing treatment. more...

Published
2013
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