4 results on '"Krivdic, B."'
Search Results
2. High content, multi-parameter analyses in buccal cells to identify Alzheimer's disease
- Author
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François, M., Fenech, M., Thomas, P., Hor, M., Rembach, A., Martins, R.N., Rainey-Smith, S.R., Masters, C.L., Ames, D., Rowe, C.C., Macaulay, S.L., Hill, A.F., Leifert, W.R., Appannah, A., Barnes, M., Barnham, K., Bedo, J., Bellingham, S., Bon, L., Bourgeat, P., Brown, B., Buckley, R., Burnham, S., Bush, A., Chandler, G., Chen, K., Clarnette, R., Collins, S., Cooke, I., Cowie, T., Cox, K., Cuningham, E., Cyarto, E., Dang, P.A.V., Darby, D., Desmond, P., Doecke, J., Dore, V., Downing, H., Dridan, B., Duesing, K., Fahey, M., Farrow, M., Faux, N., Fernandez, S., Fernando, B., Fowler, C., Fripp, J., Frost, S., Gardener, S., Gibson, S., Graham, P., Gupta, V., Hansen, D., Harrington, K., Hone, E., Horne, M., Huckstepp, B., Jones, A., Jones, G., Kamer, A., Kanagasingam, Y., Keam, L., Kowalczyk, A., Krivdic, B., Lam, C.P., Lamb, F., Lautenschlager, N., Laws, S., Lenzo, N., Leroux, H., Lftikhar, F., Li, Q-X, Lim, F., Lim, L., Lockett, L., Lucas, K., Mano, M., Marczak, C., Martins, G., Matsumoto, Y., Bird, S., McBride, S., McKay, R., Mulligan, R., Nash, T., Nigro, J., O'Keefe, G., Ong, K., Parker, B., Pedrini, S., Peiffer, J., Pejoska, S., Penny, L., Perez, K., Pertile, K., Phal, P., Porter, T., Raniga, P., Restrepo, C., Riley, M., Roberts, B., Robertson, J., Rodrigues, M., Rooney, A., Rumble, R., Ryan, T., Salvado, O., Samuel, M., Saunders, I., Savage, G., Silbert, B., Sohrabi, H.R., Syrette, J., Szoeke, C., Taddei, K., Taddei, T., Tan, S., Tegg, M., Trivedi, D., Trounson, B., Veljanovski, R., Verdile, G., Villemagne, V., Volitakis, I., Vockler, C., Vovos, M., Vrantsidis, F., Walker, S., Watt, A., Weinborn, M., Wilson, B., Woodward, M., Yastrubetskaya, O., Yates, P., Zhang, P., Chatterjee, P., Creegan, R., De Ruyck, K., Ding, H., Groth, D., Head, R., Krause, D., Lachovitzki, R., Lim, Y.Y., Lintern, T., Mondal, A., Nuttall, S., O'Callaghan, N., Osborne, L., Pang, C., Patten, G., Tuckfield, A., Varghese, J., Wilson, A., Zhang, Q., François, M., Fenech, M., Thomas, P., Hor, M., Rembach, A., Martins, R.N., Rainey-Smith, S.R., Masters, C.L., Ames, D., Rowe, C.C., Macaulay, S.L., Hill, A.F., Leifert, W.R., Appannah, A., Barnes, M., Barnham, K., Bedo, J., Bellingham, S., Bon, L., Bourgeat, P., Brown, B., Buckley, R., Burnham, S., Bush, A., Chandler, G., Chen, K., Clarnette, R., Collins, S., Cooke, I., Cowie, T., Cox, K., Cuningham, E., Cyarto, E., Dang, P.A.V., Darby, D., Desmond, P., Doecke, J., Dore, V., Downing, H., Dridan, B., Duesing, K., Fahey, M., Farrow, M., Faux, N., Fernandez, S., Fernando, B., Fowler, C., Fripp, J., Frost, S., Gardener, S., Gibson, S., Graham, P., Gupta, V., Hansen, D., Harrington, K., Hone, E., Horne, M., Huckstepp, B., Jones, A., Jones, G., Kamer, A., Kanagasingam, Y., Keam, L., Kowalczyk, A., Krivdic, B., Lam, C.P., Lamb, F., Lautenschlager, N., Laws, S., Lenzo, N., Leroux, H., Lftikhar, F., Li, Q-X, Lim, F., Lim, L., Lockett, L., Lucas, K., Mano, M., Marczak, C., Martins, G., Matsumoto, Y., Bird, S., McBride, S., McKay, R., Mulligan, R., Nash, T., Nigro, J., O'Keefe, G., Ong, K., Parker, B., Pedrini, S., Peiffer, J., Pejoska, S., Penny, L., Perez, K., Pertile, K., Phal, P., Porter, T., Raniga, P., Restrepo, C., Riley, M., Roberts, B., Robertson, J., Rodrigues, M., Rooney, A., Rumble, R., Ryan, T., Salvado, O., Samuel, M., Saunders, I., Savage, G., Silbert, B., Sohrabi, H.R., Syrette, J., Szoeke, C., Taddei, K., Taddei, T., Tan, S., Tegg, M., Trivedi, D., Trounson, B., Veljanovski, R., Verdile, G., Villemagne, V., Volitakis, I., Vockler, C., Vovos, M., Vrantsidis, F., Walker, S., Watt, A., Weinborn, M., Wilson, B., Woodward, M., Yastrubetskaya, O., Yates, P., Zhang, P., Chatterjee, P., Creegan, R., De Ruyck, K., Ding, H., Groth, D., Head, R., Krause, D., Lachovitzki, R., Lim, Y.Y., Lintern, T., Mondal, A., Nuttall, S., O'Callaghan, N., Osborne, L., Pang, C., Patten, G., Tuckfield, A., Varghese, J., Wilson, A., and Zhang, Q.
- Abstract
Alzheimer’s disease (AD) is a degenerative brain disorder and is the most common form of dementia. Minimally invasive approaches are required that combine biomarkers to identify individuals who are at risk of developing mild cognitive impairment (MCI) and AD, to appropriately target clinical trials for therapeutic discovery as well as lifestyle strategies aimed at prevention. Buccal mucosa cells from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing cohort (n=60) were investigated for cytological markers that could be used to identify both MCI and AD individuals. Visual scoring of the buccal cytome demonstrated a significantly lower frequency of basal and karyorrhectic cells in the MCI group compared with controls. A high content, automated assay was developed using laser scanning cytometry to simultaneously measure cell types, nuclear DNA content and aneuploidy, neutral lipid content, putative Tau and amyloid-β (Aβ) in buccal cells. DNA content, aneuploidy, neutral lipids and Tau were similar in all groups. However, there was significantly lower Tau protein in both basal and karyolytic buccal cell types compared with differentiated buccal cells. Aβ, as measured by frequency of cells containing Aβ signal, as well as area and integral of Aβ signal, was significantly higher in the AD group compared with the control group. Buccal cell Aβ was correlated with mini-mental state examination (MMSE) scores (r = -0.436, P=0.001) and several blood-based biomarkers. Combining newly identified biomarkers from buccal cells with those already established may offer a potential route for more specific biomarker panels which may substantially increase the likelihood of better predictive markers for earlier diagnosis of AD.
- Published
- 2016
3. High content, multi-parameter analyses in buccal cells to identify alzheimer’s disease
- Author
-
François, M., Fenech, M. F., Thomas, P., Hor, M., Rembach, A., Martins, R. N., Rainey-Smith, S. R., Masters, C. L., Ames, D., Rowe, C. C., Lance Macaulay, S., Hill, A. F., Leifert, W. R., Appannah, A., Barnes, M., Barnham, K., Bedo, J., Bellingham, S., Bon, L., Bourgeat, P., Brown, B., Buckley, R., Burnham, S., Bush, A., Chandler, G., Chen, K., Clarnette, R., Collins, S., Cooke, I., Cowie, T., Cox, K., Cuningham, E., Cyarto, E., Dang, P. A. V., Darby, D., Desmond, P., Doecke, J., Dore, V., Downing, H., Dridan, B., Duesing, K., Fahey, M., Farrow, M., Faux, N., Fenech, M., Fernandez, S., Fernando, B., Fowler, C., Francois, M., Fripp, J., Frost, S., Gardener, S., Gibson, S., Graham, P., Gupta, V., Hansen, D., Harrington, K., Hill, A., Hone, E., Horne, M., Huckstepp, B., Jones, A., Jones, G., Kamer, A., Kanagasingam, Y., Keam, L., Kowalczyk, A., Krivdic, B., Lam, C. P., Lamb, F., Lautenschlager, N., Laws, S., Leifert, W., Lenzo, N., Leroux, H., Lftikhar, F., Li, Q. -X, Lim, F., Lim, L., Lockett, L., Lucas, K., Mano, M., Marczak, C., Martins, G., Maruff, P., Matsumoto, Y., Bird, S., Mcbride, S., Mckay, R., Mulligan, R., Nash, T., Nigro, J., O Keefe, G., Ong, K., Parker, B., Pedrini, S., Peiffer, J., Pejoska, S., Penny, L., Perez, K., Pertile, K., Phal, P., Porter, T., Rainey-Smith, S., Raniga, P., Restrepo, C., Riley, M., Roberts, B., Robertson, J., Rodrigues, M., Rooney, A., Rumble, R., Ryan, T., Salvado, O., Samuel, M., Saunders, I., Savage, G., Silbert, B., Sohrabi, H., Syrette, J., Cassandra Szoeke, Taddei, K., Taddei, T., Tan, S., Tegg, M., Trivedi, D., Trounson, B., Veljanovski, R., Verdile, G., Villemagne, V., Volitakis, I., Vockler, C., Vovos, M., Vrantsidis, F., Walker, S., Watt, A., Weinborn, M., Wilson, B., Woodward, M., Yastrubetskaya, O., Yates, P., Zhang, P., Chatterjee, P., Creegan, R., Ruyck, K., Ding, H., Groth, D., Head, R., Krause, D., Lachovitzki, R., Lim, Y. Y., Lintern, T., Mondal, A., Nuttall, S., O Callaghan, N., Osborne, L., Pang, C., Patten, G., Tuckfield, A., Varghese, J., Wilson, A., and Zhang, Q.
4. The orexin₁ receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats.
- Author
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Jupp B, Krivdic B, Krstew E, and Lawrence AJ
- Subjects
- Analysis of Variance, Animals, Behavior, Animal drug effects, Conditioning, Operant drug effects, Dose-Response Relationship, Drug, Male, Naphthyridines, Orexin Receptors, Rats, Reinforcement Schedule, Reinforcement, Psychology, Self Administration, Time Factors, Urea pharmacology, Benzoxazoles pharmacology, Ethanol administration & dosage, Motivation drug effects, Receptors, G-Protein-Coupled antagonists & inhibitors, Receptors, Neuropeptide antagonists & inhibitors, Sucrose administration & dosage, Urea analogs & derivatives
- Abstract
A role for orexin A in mediating the primary and conditioned reinforcing effects of alcohol has been established. It is unclear however whether the contribution of orexins to alcohol reward occurs independently of effects on appetite and feeding, and whether orexins regulate the motivation to consume alcohol compared to other rewards. To examine this further here we investigate the effect of the orexin(1) receptor antagonist, SB-334867, on self-administration of alcohol (10% v/v) under both fixed (FR) and progressive ratio (PR) schedules of reinforcement, and whether this differs from the motivation to administer a natural food reward, sucrose (0.2-0.7% w/v) in alcohol preferring (iP) rats. SB-334867 treatment significantly reduced responding for both alcohol and sucrose under a FR3 schedule; however, at the same dose, reduced responding and break point for ethanol, but not sucrose, under a PR schedule. These findings for the first time implicate a role for orexins in the motivation to self-administer alcohol and suggest that this may occur independent of any generalized effect on appetitive drive., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
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