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177 results on '"Kritsotakis, Evangelos I."'

1. Clinical burden of community-associated infections caused by multidrug-resistant Pseudomonas aeruginosa: a propensity-matched longitudinal cohort study in Southern China

Author

Zhou, Mouqing, Xu, Baohua, Guo, Zhusheng, Zeng, Yongfeng, Lei, Jiayao, Kritsotakis, Evangelos I., and Wang, Jiancong

Subjects
community-associated infections, pseudomonas aeruginosa, multidrug-resistant pathogens, incidence density, age- and sex-specific, china, dongguan, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502
Abstract

Background: Limited research has been conducted on the burden of community-associated infections caused by multidrug-resistant (CA-MDRPa). We quantitatively modeled the incidence rate and clinical factors associated with CA-MDRPa among hospitalized patients in Southern China.Methods: Data were obtained from the local nosocomial surveillance system. Poisson regression was applied to estimate annual incidence rate ratios (IRRs) from 2018 to 2021. After propensity-score 1:2 matching, multivariable conditional logistic regression was used to identify factors for CA-MDRPa upon admission and adverse clinical outcomes during hospitalization. Results: 278 patients were clinically and microbiologically diagnosed with CA-MDRPa and 647 with CA-non-MDRPa. CA-MDRPa rate exhibited a slight, non-significant, increase during the research period (IRR=1.03; 95% confidence interval [CI], 0.93–1.15). Neurological conditions, cardiovascular diseases, respiratory disorders, urinary tract infections, and use of cefoperazone/sulbactam prior to admission were identified as risk factors for CA-MDRPa upon admission. CA-MDRPa upon admission was associated with ESBL-producing acquisition during hospitalization (odds ratio [OR], 2.70; 95% CI, 1.53–4.77) and increased in-hospital mortality (OR, 2.24; 95% CI, 1.17–4.28).Conclusions: The findings emphasize the importance of regular targeted screening for CA-MDRPa upon hospital admission and offer valuable insights for strengthening infection control and antimicrobial stewardship programs.

Published
2024
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3. Development and internal validation of a clinical prediction model for serious complications after emergency laparotomy

Author

Kokkinakis, Stamatios, Kritsotakis, Evangelos I., Paterakis, Konstantinos, Karali, Garyfallia-Apostolia, Malikides, Vironas, Kyprianou, Anna, Papalexandraki, Melina, Anastasiadis, Charalampos S., Zoras, Odysseas, Drakos, Nikolas, Kehagias, Ioannis, Kehagias, Dimitrios, Gouvas, Nikolaos, Kokkinos, Georgios, Pozotou, Ioanna, Papatheodorou, Panayiotis, Frantzeskou, Kyriakos, Schizas, Dimitrios, Syllaios, Athanasios, Palios, Ifaistion M., Nastos, Konstantinos, Perdikaris, Markos, Michalopoulos, Nikolaos V., Margaris, Ioannis, Lolis, Evangelos, Dimopoulou, Georgia, Panagiotou, Dimitrios, Nikolaou, Vasiliki, Glantzounis, Georgios K., Pappas-Gogos, George, Tepelenis, Kostas, Zacharioudakis, Georgios, Tsaramanidis, Savvas, Patsarikas, Ioannis, Stylianidis, Georgios, Giannos, Georgios, Karanikas, Michail, Kofina, Konstantinia, Markou, Markos, Chrysos, Emmanuel, and Lasithiotakis, Konstantinos

Published
2024
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6. The Hellenic Emergency Laparotomy Study (HELAS): A Prospective Multicentre Study on the Outcomes of Emergency Laparotomy in Greece

Author

Lasithiotakis, Konstantinos, Kritsotakis, Evangelos I., Kokkinakis, Stamatios, Petra, Georgia, Paterakis, Konstantinos, Karali, Garyfallia-Apostolia, Malikides, Vironas, Anastasiadis, Charalampos S., Zoras, Odysseas, Drakos, Nikolas, Kehagias, Ioannis, Kehagias, Dimitrios, Gouvas, Nikolaos, Kokkinos, Georgios, Pozotou, Ioanna, Papatheodorou, Panayiotis, Frantzeskou, Kyriakos, Schizas, Dimitrios, Syllaios, Athanasios, Palios, Ifaistion M., Nastos, Konstantinos, Perdikaris, Markos, Michalopoulos, Nikolaos V., Margaris, Ioannis, Lolis, Evangelos, Dimopoulou, Georgia, Panagiotou, Dimitrios, Nikolaou, Vasiliki, Glantzounis, Georgios K., Pappas-Gogos, George, Tepelenis, Kostas, Zacharioudakis, Georgios, Tsaramanidis, Savvas, Patsarikas, Ioannis, Stylianidis, Georgios, Giannos, Georgios, Karanikas, Michael, Kofina, Konstantinia, Markou, Markos, and Chrysos, Emmanuel

Published
2023
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11. Prospective multicenter external validation of postoperative mortality prediction tools in patients undergoing emergency laparotomy

Author

Kokkinakis, Stamatios, Kritsotakis, Evangelos I., Paterakis, Konstantinos, Karali, Garyfallia-Apostolia, Malikides, Vironas, Kyprianou, Anna, Papalexandraki, Melina, Anastasiadis, Charalampos S., Zoras, Odysseas, Drakos, Nikolas, Kehagias, Ioannis, Kehagias, Dimitrios, Gouvas, Nikolaos, Kokkinos, Georgios, Pozotou, Ioanna, Papatheodorou, Panagiotis, Frantzeskou, Kyriakos, Schizas, Dimitrios, Syllaios, Athanasios, Palios, Ifaistion M., Nastos, Konstantinos, Perdikaris, Markos, Michalopoulos, Nikolaos V., Margaris, Ioannis, Lolis, Evangelos, Dimopoulou, Georgia, Panagiotou, Dimitrios, Nikolaou, Vasiliki, Glantzounis, Georgios K., Pappas-Gogos, George, Tepelenis, Kostas, Zacharioudakis, Georgios, Tsaramanidis, Savvas, Patsarikas, Ioannis, Stylianidis, Georgios, Giannos, Georgios, Karanikas, Michail, Kofina, Konstantinia, Markou, Markos, Chrysos, Emmanuel, and Lasithiotakis, Konstantinos

Published
2023
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12. Effectiveness of telemedicine in outpatient parenteral antimicrobial therapy (Tele-OPAT): A systematic review.

Author

Durojaiye, Oyewole Christopher, Jibril, Ihsan, and Kritsotakis, Evangelos I

Subjects
PATIENT satisfaction, PARENTERAL therapy, CINAHL database, TELEMEDICINE, PATIENT safety
Abstract

Introduction: Telemedicine is increasingly used to deliver healthcare in many clinical specialities. However, the adoption of telemedicine in the delivery of outpatient parenteral antimicrobial therapy (OPAT) has been relatively slow and limited. This study aims to collate current evidence for telemedicine in OPAT regarding clinical efficacy, safety, acceptability and cost-effectiveness. Methods: We systematically searched the Cochrane Library, CINAHL, EMCARE, EMBASE and MEDLINE databases through 24 July 2022, for relevant studies published in English. Research articles and conference abstracts were included if they involved any form of telephone or video consultation in delivering parenteral antibiotics in the home or outpatient setting. Study findings were synthesised into three main themes: patient outcomes and safety, patient and provider satisfaction and cost-effectiveness. The mixed methods appraisal tool was used to review the methodological quality of the studies. PROSPERO CRD42022342874 Results: The literature search yielded 311 articles, of which 12 (five full-length articles and seven conference abstracts) reporting over 1245 telemedicine interventions were reviewed. The reported outcomes were heterogeneous. Telemedicine was cost-effective and associated with high patient satisfaction and comparable complication rates compared to conventional OPAT. Considering six comparative studies, rehospitalisation risk was lower for telemedicine than conventional OPAT (risk ratio, 0.58; 95% confidence interval, 0.38–0.88; I 2 = 31%). Discussion: The results of this review demonstrate that telemedicine has a role in delivering safe and cost-effective OPAT care, especially for patients residing in remote and geographically isolated locations. Nevertheless, high-quality studies and publication of existing data and experiences are needed to further validate this model of care delivery. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Development and internal validation of a clinical prediction model for serious complications after emergency laparotomy

Author

Kokkinakis, Stamatios, primary, Kritsotakis, Evangelos I., additional, Paterakis, Konstantinos, additional, Karali, Garyfallia-Apostolia, additional, Malikides, Vironas, additional, Kyprianou, Anna, additional, Papalexandraki, Melina, additional, Anastasiadis, Charalampos S., additional, Zoras, Odysseas, additional, Drakos, Nikolas, additional, Kehagias, Ioannis, additional, Kehagias, Dimitrios, additional, Gouvas, Nikolaos, additional, Kokkinos, Georgios, additional, Pozotou, Ioanna, additional, Papatheodorou, Panayiotis, additional, Frantzeskou, Kyriakos, additional, Schizas, Dimitrios, additional, Syllaios, Athanasios, additional, Palios, Ifaistion M., additional, Nastos, Konstantinos, additional, Perdikaris, Markos, additional, Michalopoulos, Nikolaos V., additional, Margaris, Ioannis, additional, Lolis, Evangelos, additional, Dimopoulou, Georgia, additional, Panagiotou, Dimitrios, additional, Nikolaou, Vasiliki, additional, Glantzounis, Georgios K., additional, Pappas-Gogos, George, additional, Tepelenis, Kostas, additional, Zacharioudakis, Georgios, additional, Tsaramanidis, Savvas, additional, Patsarikas, Ioannis, additional, Stylianidis, Georgios, additional, Giannos, Georgios, additional, Karanikas, Michail, additional, Kofina, Konstantinia, additional, Markou, Markos, additional, Chrysos, Emmanuel, additional, and Lasithiotakis, Konstantinos, additional

Published
2023
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21. Impact of SARS-CoV-2 Preventive Measures against Healthcare-Associated Infections from Antibiotic-Resistant ESKAPEE Pathogens: A Two-Center, Natural Quasi-Experimental Study in Greece

Author

Bolikas, Emmanouil, primary, Astrinaki, Eirini, additional, Panagiotaki, Evangelia, additional, Vitsaxaki, Efsevia, additional, Saplamidou, Stamatina, additional, Drositis, Ioannis, additional, Stafylaki, Dimitra, additional, Chamilos, Georgios, additional, Gikas, Achilleas, additional, Kofteridis, Diamantis P., additional, and Kritsotakis, Evangelos I., additional

Published
2023
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23. A carbapenem-focused antimicrobial stewardship programme implemented during the COVID-19 pandemic in a setting of high endemicity for multidrug-resistant Gram-negative bacteria

Author

Spernovasilis, Nikolaos, primary, Kritsotakis, Evangelos I, additional, Mathioudaki, Anna, additional, Vouidaski, Alexandra, additional, Spanias, Christos, additional, Petrodaskalaki, Maria, additional, Ioannou, Petros, additional, Chamilos, Georgios, additional, and Kofteridis, Diamantis P, additional

Published
2023
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24. Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic

Author

Spernovasilis, Nikolaos, primary, Kritsotakis, Evangelos I., additional, Mathioudaki, Anna, additional, Vouidaski, Alexandra, additional, Markaki, Ioulia, additional, Psaroudaki, Despoina, additional, Ioannou, Petros, additional, and Kofteridis, Diamantis P., additional

Published
2022
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26. The Hellenic Emergency Laparotomy Study (HELAS): A Prospective Multicentre Study on the Outcomes of Emergency Laparotomy in Greece

Author

Lasithiotakis, Konstantinos, primary, Kritsotakis, Evangelos I., additional, Kokkinakis, Stamatios, additional, Petra, Georgia, additional, Paterakis, Konstantinos, additional, Karali, Garyfallia-Apostolia, additional, Malikides, Vironas, additional, Anastasiadis, Charalampos S., additional, Zoras, Odysseas, additional, Drakos, Nikolas, additional, Kehagias, Ioannis, additional, Kehagias, Dimitrios, additional, Gouvas, Nikolaos, additional, Kokkinos, Georgios, additional, Pozotou, Ioanna, additional, Papatheodorou, Panayiotis, additional, Frantzeskou, Kyriakos, additional, Schizas, Dimitrios, additional, Syllaios, Athanasios, additional, Palios, Ifaistion M., additional, Nastos, Konstantinos, additional, Perdikaris, Markos, additional, Michalopoulos, Nikolaos V., additional, Margaris, Ioannis, additional, Lolis, Evangelos, additional, Dimopoulou, Georgia, additional, Panagiotou, Dimitrios, additional, Nikolaou, Vasiliki, additional, Glantzounis, Georgios K., additional, Pappas-Gogos, George, additional, Tepelenis, Kostas, additional, Zacharioudakis, Georgios, additional, Tsaramanidis, Savvas, additional, Patsarikas, Ioannis, additional, Stylianidis, Georgios, additional, Giannos, Georgios, additional, Karanikas, Michael, additional, Kofina, Konstantinia, additional, Markou, Markos, additional, and Chrysos, Emmanuel, additional

Published
2022
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31. sj-docx-1-jtt-10.1177_1357633X221131842 - Supplemental material for Effectiveness of telemedicine in outpatient parenteral antimicrobial therapy (Tele-OPAT): A systematic review

Author

Durojaiye, Oyewole Christopher, Jibril, Ihsan, and Kritsotakis, Evangelos I

Subjects
111708 Health and Community Services, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-jtt-10.1177_1357633X221131842 for Effectiveness of telemedicine in outpatient parenteral antimicrobial therapy (Tele-OPAT): A systematic review by Oyewole Christopher Durojaiye, Ihsan Jibril, and Evangelos I Kritsotakis in Journal of Telemedicine and Telecare

Published
2022
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36. Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic.

Author

Spernovasilis, Nikolaos, Kritsotakis, Evangelos I., Mathioudaki, Anna, Vouidaski, Alexandra, Markaki, Ioulia, Psaroudaki, Despoina, Ioannou, Petros, and Kofteridis, Diamantis P.

Subjects
COVID-19 pandemic, DRUG prescribing, ANTIMICROBIAL stewardship, PATIENT compliance, DRUG resistance in microorganisms
Abstract

Background: Irrational use of antimicrobials poses a significant risk for public health by aggravating antimicrobial resistance. The aim of this repeated point prevalence survey (PPS) was to evaluate the impact of a carbapenem-focused antimicrobial stewardship program (ASP) on overall antimicrobial use and quality of antimicrobial prescribing during the COVID-19 pandemic. Methods: All adult inpatients in the University Hospital of Heraklion in Greece were audited twice, before and after the implementation of the ASP, in October 2019 and October 2020, respectively. Patient characteristics, indications and diagnoses for antimicrobial administration, antimicrobials prescribed, and compliance with treatment guidelines were recorded. Results: Of 743 adult inpatients on the days of the two surveys, 398 (53.6%) were on antimicrobials for 437 diagnoses. Following implementation of the ASP, there was substantial decrease in the utilization of carbapenems (4.9% of all antibacterials prescribed in the second PPS compared to 10.3% in the first PPS). A significant improvement was observed for all indicators of the quality of antimicrobial prescribing. Conclusions: Our study demonstrated a positive impact of an ASP implementation during the first stages of the COVID-19 pandemic on reducing the use of last-line antimicrobials and improving overall quality of antimicrobial prescribing. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Artificial Intelligence in Surgical Risk Prediction.

Author

Kokkinakis, Stamatios, Kritsotakis, Evangelos I., and Lasithiotakis, Konstantinos

Subjects
*ARTIFICIAL intelligence, *ARTIFICIAL neural networks, *MACHINE learning, *CONVOLUTIONAL neural networks, *PROPORTIONAL hazards models
Abstract

A typical ML approach uses a computationally intensive algorithm to "learn" from the data in a non-parametric manner, so that it lets the data find the best fitting formula for linking the predictors with the outcome risk. Risk prediction and stratification of short-term and long-term postoperative outcomes are growing in importance and scope of application in everyday clinical practice. Large databases of non-cardiac surgery patients were utilized to derive ML models for 30-day mortality, using XGB, RF, LASSO regression and naïve Bayes approaches [[3]]. [Extracted from the article]

Published
2023
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38. Mortality associated with third generation cephalosporin-resistance in Enterobacteriaceae infections: a multicenter cohort study in Southern China

Author

Wang, Jiancong, Zhou, Mouqing, Hesketh, Therese, and Kritsotakis, Evangelos I.

Abstract

Background: Emerging third-generation cephalosporin-resistant Enterobacteriaceae (3GCR-EB) pose global healthcare concern. This study assessed the in-hospital mortality attributed to 3GCR-EB. Methods: The study cohort comprised inpatients with community-onset or healthcare-associated infection caused by Enterobacteriaceae in three tertiary-care public hospitals in 2017. In-hospital mortality was compared between 3GCR-EB infected patients and third-generation cephalosporin-susceptible Enterobacteriaceae (3GCS-EB) infected patients using competing risk survival models. Results: Of 2,343 study patients (median age 60 years; 45.2% male), 1,481 (63.2%) had 3GCS-EB and 862 (36.8%) 3GCR-EB infection. 494 (57.0%) 3GCR-EB isolates were co-resistant to fluoroquinolones and 15 (1.7%) to carbapenems. In-hospital mortality was similar in 3GCS-EB and 3GCR-EB infections (2.4% vs. 2.8%; p = 0.601). No increase in the hazard of in-hospital mortality was detected for 3GCR-EB compared to 3GCS-EB infection (sub-distribution hazard ratio [HR] 0.80; 95%CI, 0.41���1.55) adjusting for patient age, sex, intensive care admission, origin of infection and site of infection. Analysis of cause-specific hazards showed that 3GCR-EB infections significantly decreased the daily rate of hospital discharge (cause-specific HR = 0.84; 95%CI, 0.76���0.92) leading to lengthier hospitalizations. Conclusion: 3GCR-EB infection per se was not associated with increased in-hospital mortality in this study, but placed significant healthcare burden by increasing the length of hospitalization.

Published
2021
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50. Learning across the UK: a review of public health systems and policy approaches to early child development since political devolution

Author

Black, Michelle, primary, Barnes, Amy, primary, Baxter, Susan, primary, Beynon, Claire, primary, Clowes, Mark, primary, Dallat, Mary, primary, Davies, Alisha R, primary, Furber, Andrew, primary, Goyder, Elizabeth, primary, Jeffery, Catherine, primary, Kritsotakis, Evangelos I, primary, and Strong, Mark, primary

Published
2019
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