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857 results on '"Kritchevsky D"'

11. Hypercholesterolaemia and Atherosclerosis Induced in Vervet l\'lonkeys by Cholesterol-free, Semisynthetic Diets

Author

Kritchevsky, D., Davidson, L.M., Van der Watt, J.J., Winter, P.A.D., and Bersohn, I.

Abstract

Vervet monkeys (Cercopithecus aethiops pygerethrus) were fed diets containing 40% carbohydrate, 25% casein and 14% hydrogenated coconut oil for 6 months. Three carbohydrates were fed: glucose, fructose and sucrose. All three diets were cholesterolaemic, the most severe cholesterolaemias being observed in the fructose and sucrose groups. All diets led to aortic sudanophilia. The fructose diet resulted in the most severe atherosclerosis and sudanophilia. This study' demonstrates the feasibility of using semisynthetic, cholesterol-free diets for the induction of hyperlipaemia and atherosclerosis in monkeys.

Published
2018

12. In vitro binding properties of dietary fibre

Author

Kritchevsky, D.

Subjects
Fiber in human nutrition -- Analysis, Cooperative binding (Biochemistry) -- Analysis, Alfalfa -- Observations, Cellulose -- Observations
Abstract

The binding properties of insoluble and soluble fibers are determined and explain the effects of fiber on the structure of intestinal mucosa, on the toxic agents and the lignin fragment of the dry grain residue. In contrast to cellulose, beet pulp, oat hull or wheat bran, alfalfa is bound to the bile salt sodium taurocholate. The binding of cellulose is least, alfalfa and wheat bran undergo average binding and lignin binds the most to cholic, chenodeoxycholic, deoxycholic acids and their taurine and glycine conjugates.

Published
1995

16. Effects of Chenodeoxycholic Acid (CD) Treatment on Endogenous Plasma Triglyceride (TG) Transport in Hyperlipoproteinemia (HLP)

Author

Angelin, B., Einarsson, K., Leijd, B., Arreaza-Plaza, C. A., Otayek, M., Bosch, V., Avogaro, P., Bittolo-Bon, G., Pais, M., Taroni, G. C., Cazzolato, G., Quinci, G. B., Bateson, M. C., Bouchier, I. A. D., Bell, F. P., Quackenbush, F. W., Bentzen, C., Tourne, C., Wulfert, E., Bizzi, A., Garattini, S., Tacconi, A. M., Veneroni, E., Bjorkerud, S., Bondjers, G., Brattsand, R., Bylock, A., Hansson, G. K., Brindley, D. N., Burstein, M., Legmann, P., Aparicio, A. M., Boyle, E., Canosa, F. L., Cayen, M. N., Dvornik, D., Robinson, W. T., Cooper, E. E., Michel, A. M., Cowan, D. H., Robertson, A. L., Jr., Giroski, P., Shook, P., de Gennes, J. L., Piette, J. C., Piette, A. M., Truffert, J., DePalma, R. G., Bellon, E. M., Koletsky, S., Klein, L., Schneider, D. L., Ditschuneit, H. H., Klor, H. U., Ditschuneit, H., Drouin, P., Mejean, L., Wülfert, E., Eisele, B., Griss, G., Zimmer, A., Endo, A., Kitano, N., Fujii, S., Enomoto, H., Yoshikuni, Y., Ozaki, T., Zschocke, R., Ohata, K., Feldman, E. B., Gluck, F. B., Carter, A. C., Flanders, L., Nicholson, N., Fleischman, A. I., Bierenbaum, M. L., Stier, A., Fragiacomo, C., Lovati, M. R., Fox, U., Maione, G., Sirtori, C. R., Freeman, M. W., Spring-Mills, E., Jones, A. L., Gaion, R. M., Krishna, G., Galli, G., Galli-Kienle, M., Sanghvi, A., Gero, S., Szondy, E., Horvath, M., Fust, G., Szekely, J., Haacke, H., Parwaresch, M. R., Mader, Ch., Haller, H., Bruns, W., Michaelis, D., Schulze, J., Hanefeld, M., Leonhardt, W., Kemmer, C., Roschlau, G., Jaross, W., Hayes, T. M., Jones, A. W., Munn, J., Mottram, R., Hollander, W., Prusty, S., Nagraj, S., Kirkpatrick, B., Paddock, J., Colombo, M., Howard, A. N., Ghosh, P., Jackson, R. L., Kinnunen, P. K. J., Smith, L. E., Gotto, A. M., Jr., Sparrow, J. T., Jacotot, B., Girardet, M., Beaumont, J. L., Jaeger, H., Wechsler, J. G., Kabara, J. J., Vrable, R., Kanazawa, T., Terata, T., Komatsu, T., Izawa, M., Mori, H., Oike, Y., Metoki, H., Onodera, K., Ito, H., Izumiyama, S., Matsui, T., Kather, H., Simon, B., Kipshidze, N. N., Klimov, A. N., Sonina, S. I., Titova, G. V., Nagornev, V. A., Kobayakawa, T., Osuga, K., Yasuda, H., Kuzuya, F., Yoshimine, N., Lageron, A., Lang, P. D., Bablok, W., Endele, R., Koch, K., Stork, H., Schmidt, H. A. E., Lazarow, P. B., Lengsfeld, H., Brand, P., Baumgartner, H. R., Reber, K., Vecchi, M., Lithell, H., Boberg, J., Hellsing, K., Lundqvist, G., Vessby, B., Maebashi, M., Kawamura, N., Sato, M., Imamura, A., Malinow, M. R., McLaughlin, P., Stafford, C., Kohler, G. O., Livingston, A. L., Marmo, E., Vacca, C., Giordano, L., Schettino, A., Petrarca, R., Del Vecchio, F., Marshall, M., Hess, H., de Quiros, J. F. B., Mishkel, M. A., Crowther, S. M., Moltoni, D., Marinovich, M., Catapano, A., Ghiselli, G. C., Mordasini, R., Schlierf, G., Heuck, C. C., Oster, P., Schellenberg, B., Twelsick, H., Muller, K., Nakamura, H., Nagano, M., Olsson, A. G., Ballantyne, D., Carlson, L. A., Rossner, S., Walldius, G., Raetzer, H., Ostlund-Lindqvist, A.-M., Pollak, O. J., Prosdocimi, M., Caparrotta, L., Dorigo, P., Fassina, G., Puglisi, L., Maggi, F., Paoletti, R., Ferruti, P., Tanzi, M. C., Ramasarma, R., George, R., Oro, L., Rouffy, J., Chanu, B., Rousselet, F., Fredj, G., Clenet, M., Sarma, J. S. M., Bing, R. J., Sauvanet, J. P., Debry, G., Schade, R. W. B., Demacker, P., van’t Laar, A., Schaefer, E. J., Levy, R. I., Jenkins, L. L., Brewer, H. B., Jr., Schettler, G., Horsch, A. K., Schonborn, J., Heim, K., Schwartzkopff, W., Hoffmann, H., Njissen, J., Etzel, V., Zschiedrich, M., Simons, L. A., Isbister, J. P., Biggs, J. C., Stahelin, H. B., Keller, C., Mully, K., Reichlin, B., Berger, W., Story, J. A., Tepper, S. A., Kritchevsky, D., Subbiah, M. T. R., Sugano, M., Ikeda, I., Morioka, H., Thale, M., Faergeman, O., Tsushima, M., Hata, Y., Tsuchida, T., Irie, N., Goto, Y., Tulloch, B. R., Iype, P. T., Werner, I., Vogelberg, K. H., Cicmir, I., Koschinsky, Th., Greiser, E., Hutt, V., Kloer, H. U., Schoenborn, J., Weizel, A., Horsch, A., Wu, C.-C., Zimmerman, R., Hoffrichter, A., Walter, E., Ehlers, W., Andrassy, K., Weber, E., Kritchevsky, David, editor, Paoletti, Rodolfo, editor, and Holmes, William L., editor

Published
1978
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30. Epilogue

Author

Alfin-Slater, R. B., primary and Kritchevsky, D., additional

Published
1979
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35. Letter to the Editor

Author

Kritchevsky D

Subjects
Cholesterol catabolism, medicine.medical_specialty, Nutrition and Dietetics, Endocrinology, Vitamin C, Chemistry, Internal medicine, medicine, Medicine (miscellaneous)
Published
2009
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38. Energy restriction and cancer

Author

Klurfeld, D.M. and Kritchevsky, D.

Subjects
Cancer -- Genetic aspects, Cancer -- Risk factors, Bioenergetics -- Physiological aspects, Energy metabolism, Diet -- Health aspects, Obesity -- Complications, Food/cooking/nutrition
Abstract

Over 20 years ago, we began reexploring the relationship between total energy intake and development of cancer in animal models. Previous work dated back to 1909, but nutritional requirements of rodents were not known then, and older diets lacked several essential nutrients. We showed that rats given carcinogens to induce mammary or colon cancer and fed high fat diets that were restricted in total energy were significantly less likely to develop tumors. The tumors that developed were much smaller, indicating growth inhibition of transformed cells. We went on to show that insulin and insulin-like growth factor-I levels were reduced by feeding low energy diets. Both of these hormones are growth factors for a variety of cancers, are elevated in overweight people and are associated with increased risk of cancer. Our work with rodents may explain the epidemiologic observations that dietary fat is associated with increased risk of breast or colon cancer but not after adjustment for total energy intake. In addition, an animal fed an unlimited amount of food should not be regarded as normal but as the equivalent of a morbidly obese human. Therefore, we are probably seeing the effects of obesity-associated sensitivity to carcinogenesis in control rats and a more normal response in those subjected to energy restriction. Recent results with DNA microarrays show that many previously unsuspected genes are affected by energy restriction. This technique may lead to genetic or pharmacologic interventions to inhibit or treat cancer.

Published
2002

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