34 results on '"Kristjansson, Ragnar P"'
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2. Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria
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Kristjansson, Ragnar P., Oskarsson, Gudjon R., Skuladottir, Astros, Oddsson, Asmundur, Rognvaldsson, Solvi, Sveinbjornsson, Gardar, Lund, Sigrun H., Jensson, Brynjar O., Styrmisdottir, Edda L., Halldorsson, Gisli H., Ferkingstad, Egil, Eldjarn, Grimur Hjorleifsson, Beyter, Doruk, Kristmundsdottir, Snædis, Juliusson, Kristinn, Fridriksdottir, Run, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Snorradottir, Margret H., Tragante, Vinicius, Stefansdottir, Lilja, Ivarsdottir, Erna V., Bjornsdottir, Gyda, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Ludviksson, Bjorn R., Onundarson, Pall T., Saevarsdottir, Saedis, Melsted, Pall, Norddahl, Gudmundur L., Bjornsdottir, Unnur S., Olafsdottir, Thorunn, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, and Stefansson, Kari
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- 2023
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3. Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits
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Beyter, Doruk, Ingimundardottir, Helga, Oddsson, Asmundur, Eggertsson, Hannes P., Bjornsson, Eythor, Jonsson, Hakon, Atlason, Bjarni A., Kristmundsdottir, Snaedis, Mehringer, Svenja, Hardarson, Marteinn T., Gudjonsson, Sigurjon A., Magnusdottir, Droplaug N., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Kristjansson, Ragnar P., Sverrisson, Sverrir T., Holley, Guillaume, Palsson, Gunnar, Stefansson, Olafur A., Eyjolfsson, Gudmundur, Olafsson, Isleifur, Sigurdardottir, Olof, Torfason, Bjarni, Masson, Gisli, Helgason, Agnar, Thorsteinsdottir, Unnur, Holm, Hilma, Gudbjartsson, Daniel F., Sulem, Patrick, Magnusson, Olafur T., Halldorsson, Bjarni V., and Stefansson, Kari
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- 2021
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4. Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming
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Gisladottir, Rosa S., Ivarsdottir, Erna V., Helgason, Agnar, Jonsson, Lina, Hannesdottir, Nanna K., Rutsdottir, Gudrun, Arnadottir, Gudny A., Skuladottir, Astros, Jonsson, Benedikt A., Norddahl, Gudmundur L., Ulfarsson, Magnus O., Helgason, Hannes, Halldorsson, Bjarni V., Nawaz, Muhammad S., Tragante, Vinicius, Sveinbjornsson, Gardar, Thorgeirsson, Thorgeir, Oddsson, Asmundur, Kristjansson, Ragnar P., Bjornsdottir, Gyda, Thorgeirsson, Gudmundur, Jonsdottir, Ingileif, Holm, Hilma, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Stefansson, Hreinn, Sulem, Patrick, and Stefansson, Kari
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- 2020
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5. A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
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Kristjansson, Ragnar P., Benonisdottir, Stefania, Davidsson, Olafur B., Oddsson, Asmundur, Tragante, Vinicius, Sigurdsson, Jon K., Stefansdottir, Lilja, Jonsson, Stefan, Jensson, Brynjar O., Arthur, Joseph G., Arnadottir, Gudny A., Sulem, Gerald, Halldorsson, Bjarni V., Gunnarsson, Bjarni, Halldorsson, Gisli H., Stefansson, Olafur A., Oskarsson, Gudjon R., Deaton, Aimee M., Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Onundarson, Pall T., Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn R., Ludviksdottir, Dora, Olafsdottir, Thorunn A., Rafnar, Thorunn, Masson, Gisli, Zink, Florian, Bjornsdottir, Gyda, Magnusson, Olafur Th., Bjornsdottir, Unnur S., Thorleifsson, Gudmar, Norddahl, Gudmundur L., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, and Stefansson, Kari
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- 2019
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6. Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis
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Oskarsson, Gudjon R., Oddsson, Asmundur, Magnusson, Magnus K., Kristjansson, Ragnar P., Halldorsson, Gisli H., Ferkingstad, Egil, Zink, Florian, Helgadottir, Anna, Ivarsdottir, Erna V., Arnadottir, Gudny A., Jensson, Brynjar O., Katrinardottir, Hildigunnur, Sveinbjornsson, Gardar, Kristinsdottir, Anna M., Lee, Amy L., Saemundsdottir, Jona, Stefansdottir, Lilja, Sigurdsson, Jon K., Davidsson, Olafur B., Benonisdottir, Stefania, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Jonsson, Stefan, Gudmundsson, Reynir L., Asselbergs, Folkert W., Tragante, Vinicius, Gunnarsson, Bjarni, Masson, Gisli, Thorleifsson, Gudmar, Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T., Gudbjartsson, Daniel F., Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2020
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7. Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank
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Olafsdottir, Thorhildur, Thorleifsson, Gudmar, Sulem, Patrick, Stefansson, Olafur A., Medek, Helga, Olafsson, Karl, Ingthorsson, Orri, Gudmundsson, Valur, Jonsdottir, Ingileif, Halldorsson, Gisli H., Kristjansson, Ragnar P., Frigge, Michael L., Stefansdottir, Lilja, Sigurdsson, Jon K., Oddsson, Asmundur, Sigurdsson, Asgeir, Eggertsson, Hannes P., Melsted, Pall, Halldorsson, Bjarni V., Lund, Sigrun H., Styrkarsdottir, Unnur, Steinthorsdottir, Valgerdur, Gudmundsson, Julius, Holm, Hilma, Tragante, Vinicius, Asselbergs, Folkert W., Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Jonsdottir, Kristin, Rafnar, Thorunn, and Stefansson, Kari
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- 2020
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8. Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility
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Mbarek, Hamdi, Steinberg, Stacy, Nyholt, Dale R., Gordon, Scott D., Miller, Michael B., McRae, Allan F., Hottenga, Jouke Jan, Day, Felix R., Willemsen, Gonneke, de Geus, Eco J., Davies, Gareth E., Martin, Hilary C., Penninx, Brenda W., Jansen, Rick, McAloney, Kerrie, Vink, Jacqueline M., Kaprio, Jaakko, Plomin, Robert, Spector, Tim D., Magnusson, Patrik K., Reversade, Bruno, Harris, R. Alan, Aagaard, Kjersti, Kristjansson, Ragnar P., Olafsson, Isleifur, Eyjolfsson, Gudmundur Ingi, Sigurdardottir, Olof, Iacono, William G., Lambalk, Cornelis B., Montgomery, Grant W., McGue, Matt, Ong, Ken K., Perry, John R.B., Martin, Nicholas G., Stefánsson, Hreinn, Stefánsson, Kari, and Boomsma, Dorret I.
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- 2016
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9. Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
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Ferkingstad, Egil, Oddsson, Asmundur, Gretarsdottir, Solveig, Benonisdottir, Stefania, Thorleifsson, Gudmar, Deaton, Aimee M., Jonsson, Stefan, Stefansson, Olafur A., Norddahl, Gudmundur L., Zink, Florian, Arnadottir, Gudny A., Gunnarsson, Bjarni, Halldorsson, Gisli H., Helgadottir, Anna, Jensson, Brynjar O., Kristjansson, Ragnar P., Sveinbjornsson, Gardar, Sverrisson, David A., Masson, Gisli, Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Holm, Hilma, Jonsdottir, Ingileif, Olafsson, Sigurdur, Steingrimsdottir, Thora, Rafnar, Thorunn, Bjornsson, Einar S., Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Sulem, Patrick, and Stefansson, Kari
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- 2018
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10. A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease
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Arnadottir, Gudny A., Norddahl, Gudmundur L., Gudmundsdottir, Steinunn, Agustsdottir, Arna B., Sigurdsson, Snaevar, Jensson, Brynjar O., Bjarnadottir, Kristbjorg, Theodors, Fannar, Benonisdottir, Stefania, Ivarsdottir, Erna V., Oddsson, Asmundur, Kristjansson, Ragnar P., Sulem, Gerald, Alexandersson, Kristjan F., Juliusdottir, Thorhildur, Gudmundsson, Kjartan R., Saemundsdottir, Jona, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Manzanillo, Paolo, Gudjonsson, Sigurjon A., Thorisson, Gudmundur A., Magnusson, Olafur Th., Masson, Gisli, Orvar, Kjartan B., Holm, Hilma, Bjornsson, Sigurdur, Arngrimsson, Reynir, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Haraldsson, Asgeir, Sulem, Patrick, and Stefansson, Kari
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- 2018
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11. Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
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Rafnar, Thorunn, Gunnarsson, Bjarni, Stefansson, Olafur A., Sulem, Patrick, Ingason, Andres, Frigge, Michael L., Stefansdottir, Lilja, Sigurdsson, Jon K., Tragante, Vinicius, Steinthorsdottir, Valgerdur, Styrkarsdottir, Unnur, Stacey, Simon N., Gudmundsson, Julius, Arnadottir, Gudny A., Oddsson, Asmundur, Zink, Florian, Halldorsson, Gisli, Sveinbjornsson, Gardar, Kristjansson, Ragnar P., Davidsson, Olafur B., Salvarsdottir, Anna, Thoroddsen, Asgeir, Helgadottir, Elisabet A., Kristjansdottir, Katrin, Ingthorsson, Orri, Gudmundsson, Valur, Geirsson, Reynir T., Arnadottir, Ragnheidur, Gudbjartsson, Daniel F., Masson, Gisli, Asselbergs, Folkert W., Jonasson, Jon G., Olafsson, Karl, Thorsteinsdottir, Unnur, Halldorsson, Bjarni V., Thorleifsson, Gudmar, and Stefansson, Kari
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- 2018
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12. Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation
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Thorolfsdottir, Rosa B., Sveinbjornsson, Gardar, Sulem, Patrick, Nielsen, Jonas B., Jonsson, Stefan, Halldorsson, Gisli H., Melsted, Pall, Ivarsdottir, Erna V., Davidsson, Olafur B., Kristjansson, Ragnar P., Thorleifsson, Gudmar, Helgadottir, Anna, Gretarsdottir, Solveig, Norddahl, Gudmundur, Rajamani, Sridharan, Torfason, Bjarni, Valgardsson, Atli S., Sverrisson, Jon T., Tragante, Vinicius, Holmen, Oddgeir L., Asselbergs, Folkert W., Roden, Dan M., Darbar, Dawood, Pedersen, Terje R., Sabatine, Marc S., Willer, Cristen J., Løchen, Maja-Lisa, Halldorsson, Bjarni V., Jonsdottir, Ingileif, Hveem, Kristian, Arnar, David O., Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Holm, Hilma, and Stefansson, Kari
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- 2018
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13. A truncating mutation in EPOR leads to hypo-responsiveness to erythropoietin with normal haemoglobin
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Oskarsson, Gudjon R., Kristjansson, Ragnar P., Lee, Amy L., Sveinbjornsson, Gardar, Magnusson, Magnus K., Ivarsdottir, Erna V., Benonisdottir, Stefania, Oddsson, Asmundur, Davidsson, Olafur B., Saemundsdottir, Jona, Halldorsson, Gisli H., Arthur, Joseph, Arnadottir, Gudny A., Masson, Gisli, Jensson, Brynjar O., Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T., Gudbjartsson, Daniel F., Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2018
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14. A rare missense variant in NR1H4 associates with lower cholesterol levels
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Deaton, Aimee M., Sulem, Patrick, Nioi, Paul, Benonisdottir, Stefania, Ward, Lucas D., Davidsson, Olafur B., Lao, Socheata, Helgadottir, Anna, Fan, Fan, Jensson, Brynjar O., Norddahl, Gudmundur L., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Sigurdsson, Asgeir, Kristjansson, Ragnar P., Oddsson, Asmundur, Arnadottir, Gudny A., Jonsson, Hakon, Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Bjornsson, Einar S., Olafsson, Sigurdur, Steingrimsdottir, Thora, Rafnar, Thorunn, Thorgeirsson, Gudmundur, Masson, Gisli, Thorleifsson, Gudmar, Gudbjartsson, Daniel F., Holm, Hilma, Thorsteinsdottir, Unnur, and Stefansson, Kari
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- 2018
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15. Long read sequencing of 1,817 Icelanders provides insight into the role of structural variants in human disease
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Beyter, Doruk, Ingimundardottir, Helga, Eggertsson, Hannes P., Bjornsson, Eythor, Kristmundsdottir, Snaedis, Mehringer, Svenja, Jonsson, Hakon, Hardarson, Marteinn T., Magnusdottir, Droplaug N., Kristjansson, Ragnar P., Gudjonsson, Sigurjon A., Sverrisson, Sverrir T., Holley, Guillaume, Eyjolfsson, Gudmundur, Olafsson, Isleifur, Sigurdardottir, Olof, Masson, Gisli, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Sulem, Patrick, Magnusson, Olafur T., Halldorsson, Bjarni V., and Stefansson, Kari
- Abstract
Long-read sequencing (LRS) promises to improve characterization of structural variants (SVs), a major source of genetic diversity. We generated LRS data on 1,817 Icelanders using Oxford Nanopore Technologies, and identified a median of 23,111 autosomal structural variants per individual (a median of 11,506 insertions and 11,576 deletions), spanning cumulatively a median of 9.9 Mb. We found that rare SVs are larger in size than common ones and are more likely to impact protein function. We discovered an association with a rare deletion of the first exon of PCSK9 . Carriers of this deletion have 0.93 mmol/L (1.36 sd) lower LDL cholesterol levels than the population average (p-value = 2.4·10 −22 ). We show that SVs can be accurately characterized at population scale using long read sequence data in a genomewide non-targeted fashion and how these variants impact disease.
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- 2019
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16. Genetic predisposition to mosaic Y chromosome loss in blood
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Thompson, Deborah J, Genovese, Giulio, Halvardson, Jonatan, Ulirsch, Jacob C, Wright, Daniel J, Terao, Chikashi, Davidsson, Olafur B, Day, Felix R, Sulem, Patrick, Jiang, Yunxuan, Danielsson, Marcus, Davies, Hanna, Dennis, Joe, Dunlop, Malcolm G, Easton, Douglas F, Fisher, Victoria A, Zink, Florian, Houlston, Richard S, Ingelsson, Martin, Kar, Siddhartha, Kerrison, Nicola D, Kinnersley, Ben, Kristjansson, Ragnar P, Law, Philip J, Li, Rong, Loveday, Chey, Mattisson, Jonas, McCarroll, Steven A, Murakami, Yoshinori, Murray, Anna, Olszewski, Pawel, Rychlicka-Buniowska, Edyta, Scott, Robert A, Thorsteinsdottir, Unnur, Tomlinson, Ian, Moghadam, Behrooz Torabi, Turnbull, Clare, Wareham, Nicholas J, Gudbjartsson, Daniel F, International Lung Cancer Consortium (INTEGRAL-ILCCO), Breast Cancer Association Consortium, Consortium Of Investigators Of Modifiers Of BRCA1/2, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, Prostate Cancer Association Group To Investigate Cancer Associated Alterations In The Genome (PRACTICAL) Consortium, Kidney Cancer GWAS Meta-Analysis Project, EQTLGen Consortium, Biobank-Based Integrative Omics Study (BIOS) Consortium, 23andMe Research Team, Kamatani, Yoichiro, Hoffmann, Eva R, Jackson, Steve P, Stefansson, Kari, Auton, Adam, Ong, Ken K, Machiela, Mitchell J, Loh, Po-Ru, Dumanski, Jan P, Chanock, Stephen J, Forsberg, Lars A, Perry, John RB, Thompson, Deborah [0000-0003-1465-5799], Wright, Daniel [0000-0003-3983-2093], Day, Felix [0000-0003-3789-7651], Dennis, Joe [0000-0003-4591-1214], Easton, Douglas [0000-0003-2444-3247], Wareham, Nicholas [0000-0003-1422-2993], Jackson, Stephen [0000-0001-9317-7937], Ong, Kenneth [0000-0003-4689-7530], Perry, John [0000-0001-6483-3771], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Genetic Markers ,Male ,0303 health sciences ,Chromosomes, Human, Y ,Mosaicism ,Computational Biology ,Middle Aged ,Genomic Instability ,United Kingdom ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Neoplasms ,Databases, Genetic ,Leukocytes ,Humans ,Female ,Genetic Predisposition to Disease ,Chromosome Deletion ,030304 developmental biology ,Aged - Abstract
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.
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- 2019
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17. Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank
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Onderzoek Precision medicine, Circulatory Health, Team Medisch, Olafsdottir, Thorhildur, Thorleifsson, Gudmar, Sulem, Patrick, Stefansson, Olafur A, Medek, Helga, Olafsson, Karl, Ingthorsson, Orri, Gudmundsson, Valur, Jonsdottir, Ingileif, Halldorsson, Gisli H, Kristjansson, Ragnar P, Frigge, Michael L, Stefansdottir, Lilja, Sigurdsson, Jon K, Oddsson, Asmundur, Sigurdsson, Asgeir, Eggertsson, Hannes P, Melsted, Pall, Halldorsson, Bjarni V, Lund, Sigrun H, Styrkarsdottir, Unnur, Steinthorsdottir, Valgerdur, Gudmundsson, Julius, Holm, Hilma, Tragante, Vinicius, Asselbergs, Folkert W, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Jonsdottir, Kristin, Rafnar, Thorunn, Stefansson, Kari, Onderzoek Precision medicine, Circulatory Health, Team Medisch, Olafsdottir, Thorhildur, Thorleifsson, Gudmar, Sulem, Patrick, Stefansson, Olafur A, Medek, Helga, Olafsson, Karl, Ingthorsson, Orri, Gudmundsson, Valur, Jonsdottir, Ingileif, Halldorsson, Gisli H, Kristjansson, Ragnar P, Frigge, Michael L, Stefansdottir, Lilja, Sigurdsson, Jon K, Oddsson, Asmundur, Sigurdsson, Asgeir, Eggertsson, Hannes P, Melsted, Pall, Halldorsson, Bjarni V, Lund, Sigrun H, Styrkarsdottir, Unnur, Steinthorsdottir, Valgerdur, Gudmundsson, Julius, Holm, Hilma, Tragante, Vinicius, Asselbergs, Folkert W, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Jonsdottir, Kristin, Rafnar, Thorunn, and Stefansson, Kari
- Published
- 2020
18. Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis
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Team Medisch, Circulatory Health, Onderzoek Precision medicine, Oskarsson, Gudjon R, Oddsson, Asmundur, Magnusson, Magnus K, Kristjansson, Ragnar P, Halldorsson, Gisli H, Ferkingstad, Egil, Zink, Florian, Helgadottir, Anna, Ivarsdottir, Erna V, Arnadottir, Gudny A, Jensson, Brynjar O, Katrinardottir, Hildigunnur, Sveinbjornsson, Gardar, Kristinsdottir, Anna M, Lee, Amy L, Saemundsdottir, Jona, Stefansdottir, Lilja, Sigurdsson, Jon K, Davidsson, Olafur B, Benonisdottir, Stefania, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Jonsson, Stefan, Gudmundsson, Reynir L, Asselbergs, Folkert W, Tragante, Vinicius, Gunnarsson, Bjarni, Masson, Gisli, Thorleifsson, Gudmar, Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T, Gudbjartsson, Daniel F, Norddahl, Gudmundur L, Thorsteinsdottir, Unnur, Sulem, Patrick, Stefansson, Kari, Team Medisch, Circulatory Health, Onderzoek Precision medicine, Oskarsson, Gudjon R, Oddsson, Asmundur, Magnusson, Magnus K, Kristjansson, Ragnar P, Halldorsson, Gisli H, Ferkingstad, Egil, Zink, Florian, Helgadottir, Anna, Ivarsdottir, Erna V, Arnadottir, Gudny A, Jensson, Brynjar O, Katrinardottir, Hildigunnur, Sveinbjornsson, Gardar, Kristinsdottir, Anna M, Lee, Amy L, Saemundsdottir, Jona, Stefansdottir, Lilja, Sigurdsson, Jon K, Davidsson, Olafur B, Benonisdottir, Stefania, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Jonsson, Stefan, Gudmundsson, Reynir L, Asselbergs, Folkert W, Tragante, Vinicius, Gunnarsson, Bjarni, Masson, Gisli, Thorleifsson, Gudmar, Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T, Gudbjartsson, Daniel F, Norddahl, Gudmundur L, Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2020
19. Long read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits
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Beyter, Doruk, primary, Ingimundardottir, Helga, additional, Oddsson, Asmundur, additional, Eggertsson, Hannes P., additional, Bjornsson, Eythor, additional, Jonsson, Hakon, additional, Atlason, Bjarni A., additional, Kristmundsdottir, Snaedis, additional, Mehringer, Svenja, additional, Hardarson, Marteinn T., additional, Gudjonsson, Sigurjon A., additional, Magnusdottir, Droplaug N., additional, Jonasdottir, Aslaug, additional, Jonasdottir, Adalbjorg, additional, Kristjansson, Ragnar P., additional, Sverrisson, Sverrir T., additional, Holley, Guillaume, additional, Palsson, Gunnar, additional, Stefansson, Olafur A., additional, Eyjolfsson, Gudmundur, additional, Olafsson, Isleifur, additional, Sigurdardottir, Olof, additional, Torfason, Bjarni, additional, Masson, Gisli, additional, Helgason, Agnar, additional, Thorsteinsdottir, Unnur, additional, Holm, Hilma, additional, Gudbjartsson, Daniel F., additional, Sulem, Patrick, additional, Magnusson, Olafur T., additional, Halldorsson, Bjarni V., additional, and Stefansson, Kari, additional
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- 2019
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20. Sequence variants associating with urinary biomarkers
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Onderzoek Precision medicine, Circulatory Health, Team Medisch, Benonisdottir, Stefania, Kristjansson, Ragnar P, Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Mikaelsdottir, Evgenia, Kehr, Birte, Jensson, Brynjar O, Arnadottir, Gudny A, Sulem, Gerald, Sveinbjornsson, Gardar, Kristmundsdottir, Snaedis, Ivarsdottir, Erna V, Vogel, Lotte K, Tragante, Vinicius, Gunnarsson, Bjarni, Runolfsdottir, Hrafnhildur Linnet, Arthur, Joseph G, Deaton, Aimee M, Eyjolfsson, Gudmundur I, Davidsson, Olafur B, Asselbergs, Folkert W, Hreidarsson, Astradur B, Rafnar, Thorunn, Thorleifsson, Gudmar, Edvardsson, Vidar, Sigurdsson, Gunnar, Helgadottir, Anna, Halldorsson, Bjarni V, Masson, Gisli, Holm, Hilma, Onundarson, Pall T, Indridason, Olafur S, Benediktsson, Rafn, Palsson, Runolfur, Gudbjartsson, Daniel F, Olafsson, Isleifur, Thorsteinsdottir, Unnur, Sulem, Patrick, Stefansson, Kari, Onderzoek Precision medicine, Circulatory Health, Team Medisch, Benonisdottir, Stefania, Kristjansson, Ragnar P, Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Mikaelsdottir, Evgenia, Kehr, Birte, Jensson, Brynjar O, Arnadottir, Gudny A, Sulem, Gerald, Sveinbjornsson, Gardar, Kristmundsdottir, Snaedis, Ivarsdottir, Erna V, Vogel, Lotte K, Tragante, Vinicius, Gunnarsson, Bjarni, Runolfsdottir, Hrafnhildur Linnet, Arthur, Joseph G, Deaton, Aimee M, Eyjolfsson, Gudmundur I, Davidsson, Olafur B, Asselbergs, Folkert W, Hreidarsson, Astradur B, Rafnar, Thorunn, Thorleifsson, Gudmar, Edvardsson, Vidar, Sigurdsson, Gunnar, Helgadottir, Anna, Halldorsson, Bjarni V, Masson, Gisli, Holm, Hilma, Onundarson, Pall T, Indridason, Olafur S, Benediktsson, Rafn, Palsson, Runolfur, Gudbjartsson, Daniel F, Olafsson, Isleifur, Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
- Published
- 2019
21. Sequence variants associating with urinary biomarkers
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Benonisdottir, Stefania, primary, Kristjansson, Ragnar P, additional, Oddsson, Asmundur, additional, Steinthorsdottir, Valgerdur, additional, Mikaelsdottir, Evgenia, additional, Kehr, Birte, additional, Jensson, Brynjar O, additional, Arnadottir, Gudny A, additional, Sulem, Gerald, additional, Sveinbjornsson, Gardar, additional, Kristmundsdottir, Snaedis, additional, Ivarsdottir, Erna V, additional, Tragante, Vinicius, additional, Gunnarsson, Bjarni, additional, Runolfsdottir, Hrafnhildur Linnet, additional, Arthur, Joseph G, additional, Deaton, Aimee M, additional, Eyjolfsson, Gudmundur I, additional, Davidsson, Olafur B, additional, Asselbergs, Folkert W, additional, Hreidarsson, Astradur B, additional, Rafnar, Thorunn, additional, Thorleifsson, Gudmar, additional, Edvardsson, Vidar, additional, Sigurdsson, Gunnar, additional, Helgadottir, Anna, additional, Halldorsson, Bjarni V, additional, Masson, Gisli, additional, Holm, Hilma, additional, Onundarson, Pall T, additional, Indridason, Olafur S, additional, Benediktsson, Rafn, additional, Palsson, Runolfur, additional, Gudbjartsson, Daniel F, additional, Olafsson, Isleifur, additional, Thorsteinsdottir, Unnur, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2018
- Full Text
- View/download PDF
22. Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation
- Author
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Thorolfsdottir, Rosa B, Sveinbjornsson, Gardar, Sulem, Patrick, Nielsen, Jonas B, Jonsson, Stefan, Halldorsson, Gisli H, Melsted, Pall, Ivarsdottir, Erna V, Davidsson, Olafur B, Kristjansson, Ragnar P, Thorleifsson, Gudmar, Helgadottir, Anna, Gretarsdottir, Solveig, Norddahl, Gudmundur, Rajamani, Sridharan, Torfason, Bjarni, Valgardsson, Atli S, Sverrisson, Jon T, Tragante, Vinicius, Holmen, Oddgeir L, Asselbergs, Folkert W, Roden, Dan M, Darbar, Dawood, Pedersen, Terje R, Sabatine, Marc S, Willer, Cristen J, Løchen, Maja-Lisa, Halldorsson, Bjarni V, Jonsdottir, Ingileif, Hveem, Kristian, Arnar, David O, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, Stefansson, Kari, Thorolfsdottir, Rosa B, Sveinbjornsson, Gardar, Sulem, Patrick, Nielsen, Jonas B, Jonsson, Stefan, Halldorsson, Gisli H, Melsted, Pall, Ivarsdottir, Erna V, Davidsson, Olafur B, Kristjansson, Ragnar P, Thorleifsson, Gudmar, Helgadottir, Anna, Gretarsdottir, Solveig, Norddahl, Gudmundur, Rajamani, Sridharan, Torfason, Bjarni, Valgardsson, Atli S, Sverrisson, Jon T, Tragante, Vinicius, Holmen, Oddgeir L, Asselbergs, Folkert W, Roden, Dan M, Darbar, Dawood, Pedersen, Terje R, Sabatine, Marc S, Willer, Cristen J, Løchen, Maja-Lisa, Halldorsson, Bjarni V, Jonsdottir, Ingileif, Hveem, Kristian, Arnar, David O, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, and Stefansson, Kari
- Published
- 2018
23. Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation
- Author
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Onderzoek Precision medicine, Circulatory Health, Team Medisch, Thorolfsdottir, Rosa B, Sveinbjornsson, Gardar, Sulem, Patrick, Nielsen, Jonas B, Jonsson, Stefan, Halldorsson, Gisli H, Melsted, Pall, Ivarsdottir, Erna V, Davidsson, Olafur B, Kristjansson, Ragnar P, Thorleifsson, Gudmar, Helgadottir, Anna, Gretarsdottir, Solveig, Norddahl, Gudmundur, Rajamani, Sridharan, Torfason, Bjarni, Valgardsson, Atli S, Sverrisson, Jon T, Tragante, Vinicius, Holmen, Oddgeir L, Asselbergs, Folkert W, Roden, Dan M, Darbar, Dawood, Pedersen, Terje R, Sabatine, Marc S, Willer, Cristen J, Løchen, Maja-Lisa, Halldorsson, Bjarni V, Jonsdottir, Ingileif, Hveem, Kristian, Arnar, David O, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, Stefansson, Kari, Onderzoek Precision medicine, Circulatory Health, Team Medisch, Thorolfsdottir, Rosa B, Sveinbjornsson, Gardar, Sulem, Patrick, Nielsen, Jonas B, Jonsson, Stefan, Halldorsson, Gisli H, Melsted, Pall, Ivarsdottir, Erna V, Davidsson, Olafur B, Kristjansson, Ragnar P, Thorleifsson, Gudmar, Helgadottir, Anna, Gretarsdottir, Solveig, Norddahl, Gudmundur, Rajamani, Sridharan, Torfason, Bjarni, Valgardsson, Atli S, Sverrisson, Jon T, Tragante, Vinicius, Holmen, Oddgeir L, Asselbergs, Folkert W, Roden, Dan M, Darbar, Dawood, Pedersen, Terje R, Sabatine, Marc S, Willer, Cristen J, Løchen, Maja-Lisa, Halldorsson, Bjarni V, Jonsdottir, Ingileif, Hveem, Kristian, Arnar, David O, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, and Stefansson, Kari
- Published
- 2018
24. Mutations in RPL3L and MYZAP increase risk of atrial fibrillation
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Thorolfsdottir, Rosa B., primary, Sveinbjornsson, Gardar, additional, Sulem, Patrick, additional, Jonsson, Stefan, additional, Halldorsson, Gisli H., additional, Melsted, Pall, additional, Ivarsdottir, Erna V., additional, Davidsson, Olafur B., additional, Kristjansson, Ragnar P., additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gretarsdottir, Solveig, additional, Norddahl, Gudmundur, additional, Rajamani, Sridharan, additional, Torfason, Bjarni, additional, Valgardsson, Atli S., additional, Sverrisson, Jon T., additional, Tragante, Vinicius, additional, Asselbergs, Folkert W., additional, Roden, Dan M., additional, Darbar, Dawood, additional, Pedersen, Terje R., additional, Sabatine, Marc S., additional, Løchen, Maja-Lisa, additional, Halldorsson, Bjarni V., additional, Jonsdottir, Ingileif, additional, Arnar, David O., additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, and Stefansson, Kari, additional
- Published
- 2017
- Full Text
- View/download PDF
25. COPA syndrome in an Icelandic family caused by a recurrent missense mutation in COPA
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Jensson, Brynjar O., primary, Hansdottir, Sif, additional, Arnadottir, Gudny A., additional, Sulem, Gerald, additional, Kristjansson, Ragnar P., additional, Oddsson, Asmundur, additional, Benonisdottir, Stefania, additional, Jonsson, Hakon, additional, Helgason, Agnar, additional, Saemundsdottir, Jona, additional, Magnusson, Olafur T., additional, Masson, Gisli, additional, Thorisson, Gudmundur A., additional, Jonasdottir, Adalbjorg, additional, Jonasdottir, Aslaug, additional, Sigurdsson, Asgeir, additional, Jonsdottir, Ingileif, additional, Petursdottir, Vigdis, additional, Kristinsson, Jon R., additional, Gudbjartsson, Daniel F., additional, Thorsteinsdottir, Unnur, additional, Arngrimsson, Reynir, additional, Sulem, Patrick, additional, Gudmundsson, Gunnar, additional, and Stefansson, Kari, additional
- Published
- 2017
- Full Text
- View/download PDF
26. Compound heterozygous mutations in UBA5 causing early-onset epileptic encephalopathy in two sisters
- Author
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Arnadottir, Gudny A., primary, Jensson, Brynjar O., additional, Marelsson, Sigurdur E., additional, Sulem, Gerald, additional, Oddsson, Asmundur, additional, Kristjansson, Ragnar P., additional, Benonisdottir, Stefania, additional, Gudjonsson, Sigurjon A., additional, Masson, Gisli, additional, Thorisson, Gudmundur A., additional, Saemundsdottir, Jona, additional, Magnusson, Olafur Th., additional, Jonasdottir, Adalbjorg, additional, Jonasdottir, Aslaug, additional, Sigurdsson, Asgeir, additional, Gudbjartsson, Daniel F., additional, Thorsteinsdottir, Unnur, additional, Arngrimsson, Reynir, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2017
- Full Text
- View/download PDF
27. Sequence variant at 4q25 near PITX2 associates with appendicitis
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Kristjansson, Ragnar P., primary, Benonisdottir, Stefania, additional, Oddsson, Asmundur, additional, Galesloot, Tessel E., additional, Thorleifsson, Gudmar, additional, Aben, Katja K., additional, Davidsson, Olafur B., additional, Jonsson, Stefan, additional, Arnadottir, Gudny A., additional, Jensson, Brynjar O., additional, Walters, G. Bragi, additional, Sigurdsson, Jon K., additional, Sigurdsson, Snaevar, additional, Holm, Hilma, additional, Arnar, David O., additional, Thorgeirsson, Gudmundur, additional, Alexiusdottir, Kristin, additional, Jonsdottir, Ingileif, additional, Thorsteinsdottir, Unnur, additional, Kiemeney, Lambertus A., additional, Jonsson, Thorvaldur, additional, Gudbjartsson, Daniel F., additional, Rafnar, Thorunn, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2017
- Full Text
- View/download PDF
28. A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease
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Bjornsson, Eythor, primary, Helgason, Hannes, additional, Halldorsson, Gisli, additional, Helgadottir, Anna, additional, Gylfason, Arnaldur, additional, Kehr, Birte, additional, Jonasdottir, Adalbjorg, additional, Jonasdottir, Aslaug, additional, Sigurdsson, Asgeir, additional, Oddsson, Asmundur, additional, Thorleifsson, Gudmar, additional, Magnusson, Olafur Th., additional, Gretarsdottir, Solveig, additional, Zink, Florian, additional, Kristjansson, Ragnar P., additional, Asgeirsdottir, Margret, additional, Swinkels, Dorine W., additional, Kiemeney, Lambertus A., additional, Eyjolfsson, Gudmundur I., additional, Sigurdardottir, Olof, additional, Masson, Gisli, additional, Olafsson, Isleifur, additional, Thorgeirsson, Gudmundur, additional, Holm, Hilma, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F., additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2017
- Full Text
- View/download PDF
29. Sequence variants associating with urinary biomarkers.
- Author
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Benonisdottir, Stefania, Kristjansson, Ragnar P, Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Mikaelsdottir, Evgenia, Kehr, Birte, Jensson, Brynjar O, Arnadottir, Gudny A, Sulem, Gerald, Sveinbjornsson, Gardar, Kristmundsdottir, Snaedis, Ivarsdottir, Erna V, Tragante, Vinicius, Gunnarsson, Bjarni, Runolfsdottir, Hrafnhildur Linnet, Arthur, Joseph G, Deaton, Aimee M, Eyjolfsson, Gudmundur I, Davidsson, Olafur B, and Asselbergs, Folkert W
- Published
- 2019
- Full Text
- View/download PDF
30. Epigenetic and genetic components of height regulation
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Benonisdottir, Stefania, primary, Oddsson, Asmundur, additional, Helgason, Agnar, additional, Kristjansson, Ragnar P., additional, Sveinbjornsson, Gardar, additional, Oskarsdottir, Arna, additional, Thorleifsson, Gudmar, additional, Davidsson, Olafur B., additional, Arnadottir, Gudny A., additional, Sulem, Gerald, additional, Jensson, Brynjar O., additional, Holm, Hilma, additional, Alexandersson, Kristjan F., additional, Tryggvadottir, Laufey, additional, Walters, G. Bragi, additional, Gudjonsson, Sigurjon A., additional, Ward, Lucas D., additional, Sigurdsson, Jon K., additional, Iordache, Paul D., additional, Frigge, Michael L., additional, Rafnar, Thorunn, additional, Kong, Augustine, additional, Masson, Gisli, additional, Helgason, Hannes, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F., additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2016
- Full Text
- View/download PDF
31. Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase
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Kristjansson, Ragnar P., primary, Oddsson, Asmundur, additional, Helgason, Hannes, additional, Sveinbjornsson, Gardar, additional, Arnadottir, Gudny A., additional, Jensson, Brynjar O., additional, Jonasdottir, Aslaug, additional, Jonasdottir, Adalbjorg, additional, Bragi Walters, G., additional, Sulem, Gerald, additional, Oskarsdottir, Arna, additional, Benonisdottir, Stefania, additional, Davidsson, Olafur B., additional, Masson, Gisli, additional, Th Magnusson, Olafur, additional, Holm, Hilma, additional, Sigurdardottir, Olof, additional, Jonsdottir, Ingileif, additional, Eyjolfsson, Gudmundur I., additional, Olafsson, Isleifur, additional, Gudbjartsson, Daniel F., additional, Thorsteinsdottir, Unnur, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2016
- Full Text
- View/download PDF
32. Genetic predisposition to mosaic Y chromosome loss in blood
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Thompson, Deborah J., Genovese, Giulio, Halvardson, Jonatan, Ulirsch, Jacob C., Wright, Daniel J., Terao, Chikashi, Davidsson, Olafur B., Day, Felix R., Sulem, Patrick, Jiang, Yunxuan, Danielsson, Marcus, Davies, Hanna, Dennis, Joe, Dunlop, Malcolm G., Easton, Douglas F., Fisher, Victoria A., Zink, Florian, Houlston, Richard S., Ingelsson, Martin, Kar, Siddhartha, Kerrison, Nicola D., Kinnersley, Ben, Kristjansson, Ragnar P., Law, Philip J., Li, Rong, Loveday, Chey, Mattisson, Jonas, McCarroll, Steven A., Murakami, Yoshinori, Murray, Anna, Olszewski, Pawel, Rychlicka-Buniowska, Edyta, Scott, Robert A., Thorsteinsdottir, Unnur, Tomlinson, Ian, Moghadam, Behrooz Torabi, Turnbull, Clare, Wareham, Nicholas J., Gudbjartsson, Daniel F., Kamatani, Yoichiro, Hoffmann, Eva R., Jackson, Steve P., Stefansson, Kari, Auton, Adam, Ong, Ken K., Machiela, Mitchell J., Loh, Po-Ru, Dumanski, Jan P., Chanock, Stephen J., Forsberg, Lars A., and Perry, John R. B.
- Abstract
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1–5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n= 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.
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- 2019
- Full Text
- View/download PDF
33. A loss-of-function variant in ALOX15protects against nasal polyps and chronic rhinosinusitis
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Kristjansson, Ragnar P., Benonisdottir, Stefania, Davidsson, Olafur B., Oddsson, Asmundur, Tragante, Vinicius, Sigurdsson, Jon K., Stefansdottir, Lilja, Jonsson, Stefan, Jensson, Brynjar O., Arthur, Joseph G., Arnadottir, Gudny A., Sulem, Gerald, Halldorsson, Bjarni V., Gunnarsson, Bjarni, Halldorsson, Gisli H., Stefansson, Olafur A., Oskarsson, Gudjon R., Deaton, Aimee M., Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Onundarson, Pall T., Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn R., Ludviksdottir, Dora, Olafsdottir, Thorunn A., Rafnar, Thorunn, Masson, Gisli, Zink, Florian, Bjornsdottir, Gyda, Magnusson, Olafur Th., Bjornsdottir, Unnur S., Thorleifsson, Gudmar, Norddahl, Gudmundur L., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, and Stefansson, Kari
- Abstract
Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We also tested 210 markers reported to associate with eosinophil count, yielding 17 additional NP associations. Of the 27 NP signals, 7 associate with CRS and 13 with asthma. Most notably, a missense variant in ALOX15that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P=8.0 × 10−27, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P=1.1 × 10−8, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. Our findings identify 15-LO as a potential target for therapeutic intervention in NP and CRS.
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- 2019
- Full Text
- View/download PDF
34. Modelling weather dependence in online reliability assessment of power systems
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Podofillini, Luca, Sudret, Bruno, Stojadinović, Božidar, Zio, Enrico, Kröger, Wolfgang, Perkin, Samuel, Svendsen, Arne Brufladt, Tollefsen, Trond, Honve, Ingrid, Baldursdottir, Iris, Stefansson, Hlynur, Kristjansson, Ragnar, and Jensson, Pall
- Abstract
Probabilistic reliability assessment of power systems is an ongoing field of research, particularly in the development of tools to model the probability of exogenous threats and their potential consequences. This paper describes the application of a weather-dependent failure rate model to a region of the Icelandic transmission system, using 10 years of weather data and overhead line fault records. The studied failure rate model is compared with a constant failure rate model, in terms of variability and how well the models perform in a blind test over a 2 year period in reflecting the occurrence of outages. The weather-dependent and constant failure rate models are used as input to a state-of-the-art risk assessment tool to determine the sensitivity of such software to weather-dependent threats. The results show the importance of weather-dependent contingency probabilities in risk estimation, and in quantitative assessment of maintenance activities. The results also demonstrate that inclusion of weather dependence in power system reliability assessments affects the overall distribution of risk as a positively skewed distribution, with high-risk periods occurring at low frequency.
- Published
- 2017
- Full Text
- View/download PDF
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