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ZusammenfassungDas Lipödem ist eine chronische, progrediente, schmerzhafte, übermäßige Fettgewebsvermehrung bei Frauen mit deutlicher Disproportion zwischen Stamm und Extremitäten 1. Zusätzlich bestehen Ödeme, die durch Orthostase verstärkt werden, sowie eine Hämatomneigung nach Bagatelltraumen 2 3 4. Die Ursache ist unbekannt, daher gibt es keine kausale Therapiemöglichkeit. Die vielfach empfohlene komplexe physikalische Entstauungstherapie (KPE), bestehend aus manueller Lymphdrainage und Kompression, ist nur gegen die Ödemkomponente wirksam.Eine dauerhafte Reduktion des krankhaften Unterhautfettgewebes an Beinen und Armen ist mittels Liposuktion durch die Mikrokanülentechnik in Tumeszenz-Lokalanästhesie möglich geworden 5.

Background Intestinal anastomotic insufficiency (AI) is a common problem in visceral surgery associated with overexpression of matrix metalloproteinases (MMPs). In some patients it occurs more than once. The etiology of recurring anastomotic insufficiency (RAI) is not understood yet and should be addressed as an independent disease entity. Materials and methods Thirty nine consecutive patients with AI were treated at our university center and were included in this prospective study. Clinical data were evaluated by correlative statistical analysis to identify independent risk factors for RAI. Patients were divided in two groups: 18 patients had a single operative revision until restoration (group SAI), and 21 patients had two or more revisions (group RAI). Anastomotic tissue samples as well as untouched bowel wall were collected during reoperations for analysis of MMPs and tissue inhibitor of metalloproteinases (TIMP2). Clinical data were correlated with pathological observations. Results Significant differences of clinical and molecular pathological data were found between the two groups. Transfusion of red blood cells until the first reoperation and alcohol abuse led to RAI and were the only independent risk factors for RAI in multivariate analysis. Overexpression of MMP-8, -9, and -13 in anastomotic tissue correlated with the administration of red blood cells during initial operation. Reduced expression of TIMP2 was frequent in nearly all patients without differences throughout the subgroups. Conclusions RAI seems to have an independent disease pattern. Transfusion of blood products is not only a known risk factor for AI but seems to significantly disturb the anastomotic healing process leading to RAI.