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1. Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data

Author

Jo, Taeho, Kim, Junpyo, Bice, Paula, Huynh, Kevin, Wang, Tingting, Arnold, Matthias, Meikle, Peter J, Giles, Corey, Kaddurah-Daouk, Rima, Saykin, Andrew J, Nho, Kwangsik, Kueider-Paisley, Alexandra, Doraiswamy, P Murali, Blach, Colette, Moseley, Arthur, Thompson, Will, St John-Williams, Lisa, Mahmoudiandehkhordi, Siamak, Tenenbaum, Jessica, Welsh-Balmer, Kathleen, Plassman, Brenda, Risacher, Shannon L, Kastenmüller, Gabi, Han, Xianlin, Baillie, Rebecca, Knight, Rob, Dorrestein, Pieter, Brewer, James, Mayer, Emeran, Labus, Jennifer, Baldi, Pierre, Gupta, Arpana, Fiehn, Oliver, Barupal, Dinesh, Meikle, Peter, Mazmanian, Sarkis, Rader, Dan, Kling, Mitchel, Shaw, Leslie, Trojanowski, John, van Duijin, Cornelia, Nevado-Holgado, Alejo, Bennett, David, Krishnan, Ranga, Keshavarzian, Ali, Vogt, Robin, Ikram, Arfan, Hankemeier, Thomas, Thiele, Ines, Price, Nathan, Funk, Cory, Baloni, Priyanka, Jia, Wei, Wishart, David, Brinton, Roberta, Chang, Rui, Farrer, Lindsay, Au, Rhoda, Qiu, Wendy, Würtz, Peter, Koal, Therese, Mangravite, Lara, Krumsiek, Jan, Suhre, Karsten, Newman, John, Moreno, Herman, Foroud, Tatania, Sacks, Frank, Jansson, Janet, Weiner, Michael W, Aisen, Paul, Petersen, Ronald, Jack, Clifford R, Jagust, William, Trojanowki, John Q, Toga, Arthur W, Beckett, Laurel, Green, Robert C, Morris, John C, Perrin, Richard J, Shaw, Leslie M, Khachaturian, Zaven, Carrillo, Maria, Potter, William, Barnes, Lisa, Bernard, Marie, Gonzalez, Hector, Ho, Carole, Hsiao, John K, Jackson, Jonathan, Masliah, Eliezer, Masterman, Donna, Okonkwo, Ozioma, Perrin, Richard, and Ryan, Laurie

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Alzheimer's Disease, Dementia, Aging, Machine Learning and Artificial Intelligence, Networking and Information Technology R&D (NITRD), Brain Disorders, Neurodegenerative, Neurological, Humans, Aged, Magnetic Resonance Imaging, Deep Learning, Alzheimer Disease, Neuroimaging, Metabolome, Lipids, Cognitive Dysfunction, Alzheimer's Disease Metabolomics Consortium, Alzheimer's Disease Neuroimaging Initiative, Alzheimer's disease, Deep learning, Lipidomics, Machine learning, Metabolomics, Clinical Sciences, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundDeep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. This study introduces the Circular-Sliding Window Association Test (c-SWAT) to improve the classification accuracy in predicting AD using serum-based metabolomics data, specifically lipidomics.MethodsThe c-SWAT methodology builds upon the existing Sliding Window Association Test (SWAT) and utilizes a three-step approach: feature correlation analysis, feature selection, and classification. Data from 997 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) served as the basis for model training and validation. Feature correlations were analyzed using Weighted Gene Co-expression Network Analysis (WGCNA), and Convolutional Neural Networks (CNN) were employed for feature selection. Random Forest was used for the final classification.FindingsThe application of c-SWAT resulted in a classification accuracy of up to 80.8% and an AUC of 0.808 for distinguishing AD from cognitively normal older adults. This marks a 9.4% improvement in accuracy and a 0.169 increase in AUC compared to methods without c-SWAT. These results were statistically significant, with a p-value of 1.04 × 10ˆ-4. The approach also identified key lipids associated with AD, such as Cer(d16:1/22:0) and PI(37:6).InterpretationOur results indicate that c-SWAT is effective in improving classification accuracy and in identifying potential lipid biomarkers for AD. These identified lipids offer new avenues for understanding AD and warrant further investigation.FundingThe specific funding of this article is provided in the acknowledgements section.

Published
2023

3. Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data

Author

Kaddurah-Daouk, Rima, Kueider-Paisley, Alexandra, Doraiswamy, P. Murali, Blach, Colette, Moseley, Arthur, Thompson, Will, St John-Williams, Lisa, Mahmoudiandehkhordi, Siamak, Tenenbaum, Jessica, Welsh-Balmer, Kathleen, Plassman, Brenda, Saykin, Andrew J., Nho, Kwangsik, Risacher, Shannon L., Kastenmüller, Gabi, Arnold, Matthias, Han, Xianlin, Baillie, Rebecca, Knight, Rob, Dorrestein, Pieter, Brewer, James, Mayer, Emeran, Labus, Jennifer, Baldi, Pierre, Gupta, Arpana, Fiehn, Oliver, Barupal, Dinesh, Meikle, Peter, Mazmanian, Sarkis, Rader, Dan, Kling, Mitchel, Shaw, Leslie, Trojanowski, John, van Duijin, Cornelia, Nevado-Holgado, Alejo, Bennett, David, Krishnan, Ranga, Keshavarzian, Ali, Vogt, Robin, Ikram, Arfan, Hankemeier, Thomas, Thiele, Ines, Price, Nathan, Funk, Cory, Baloni, Priyanka, Jia, Wei, Wishart, David, Brinton, Roberta, Chang, Rui, Farrer, Lindsay, Au, Rhoda, Qiu, Wendy, Würtz, Peter, Koal, Therese, Mangravite, Lara, Krumsiek, Jan, Suhre, Karsten, Newman, John, Moreno, Herman, Foroud, Tatania, Sacks, Frank, Jansson, Janet, Weiner, Michael W., Aisen, Paul, Petersen, Ronald, Jack, Clifford R., Jr., Jagust, William, Trojanowki, John Q., Toga, Arthur W., Beckett, Laurel, Green, Robert C., Morris, John C., Perrin, Richard J., Shaw, Leslie M., Khachaturian, Zaven, Carrillo, Maria, Potter, William, Barnes, Lisa, Bernard, Marie, Gonzalez, Hector, Ho, Carole, Hsiao, John K., Jackson, Jonathan, Masliah, Eliezer, Masterman, Donna, Okonkwo, Ozioma, Perrin, Richard, Ryan, Laurie, Silverberg, Nina, Fleisher, Adam, Sacrey, Diana Truran, Fockler, Juliet, Conti, Cat, Veitch, Dallas, Neuhaus, John, Jin, Chengshi, Nosheny, Rachel, Ashford, Miriam, Flenniken, Derek, Kormos, Adrienne, Montine, Tom, Rafii, Michael, Raman, Rema, Jimenez, Gustavo, Donohue, Michael, Gessert, Devon, Salazar, Jennifer, Zimmerman, Caileigh, Cabrera, Yuliana, Walter, Sarah, Miller, Garrett, Coker, Godfrey, Clanton, Taylor, Hergesheimer, Lindsey, Smith, Stephanie, Adegoke, Olusegun, Mahboubi, Payam, Moore, Shelley, Pizzola, Jeremy, Shaffer, Elizabeth, Sloan, Brittany, Harvey, Danielle, Forghanian-Arani, Arvin, Borowski, Bret, Ward, Chad, Schwarz, Christopher, Jones, David, Gunter, Jeff, Kantarci, Kejal, Senjem, Matthew, Vemuri, Prashanthi, Reid, Robert, Fox, Nick C., Malone, Ian, Thompson, Paul, Thomopoulos, Sophia I., Nir, Talia M., Jahanshad, Neda, DeCarli, Charles, Knaack, Alexander, Fletcher, Evan, Tosun-Turgut, Duygu, Chen, Stephanie Rossi, Choe, Mark, Crawford, Karen, Yushkevich, Paul A., Das, Sandhitsu, Koeppe, Robert A., Reiman, Eric M., Chen, Kewei, Mathis, Chet, Landau, Susan, Cairns, Nigel J., Householder, Erin, Franklin, Erin, Bernhardt, Haley, Taylor-Reinwald, Lisa, Korecka, Magdalena, Figurski, Michal, Neu, Scott, Apostolova, Liana G., Shen, Li, Foroud, Tatiana M., Nudelman, Kelly, Faber, Kelley, Wilmes, Kristi, Thal, Leon, Silbert, Lisa C., Lind, Betty, Crissey, Rachel, Kaye, Jeffrey A., Carter, Raina, Dolen, Sara, Quinn, Joseph, Schneider, Lon S., Pawluczyk, Sonia, Becerra, Mauricio, Teodoro, Liberty, Dagerman, Karen, Spann, Bryan M., Vanderswag, Helen, Ziolkowski, Jaimie, Heidebrink, Judith L., Zbizek-Nulph, Lisa, Lord, Joanne L., Mason, Sara S., Albers, Colleen S., Knopman, David, Johnson, Kris, Villanueva-Meyer, Javier, Pavlik, Valory, Pacini, Nathaniel, Lamb, Ashley, Kass, Joseph S., Doody, Rachelle S., Shibley, Victoria, Chowdhury, Munir, Rountree, Susan, Dang, Mimi, Stern, Yaakov, Honig, Lawrence S., Mintz, Akiva, Ances, Beau, Winkfield, David, Carroll, Maria, Stobbs-Cucchi, Georgia, Oliver, Angela, Creech, Mary L., Mintun, Mark A., Schneider, Stacy, Geldmacher, David, Love, Marissa Natelson, Griffith, Randall, Clark, David, Brockington, John, Marson, Daniel, Grossman, Hillel, Goldstein, Martin A., Greenberg, Jonathan, Mitsis, Effie, Shah, Raj C., Lamar, Melissa, Samuels, Patricia, Duara, Ranjan, Greig-Custo, Maria T., Rodriguez, Rosemarie, Albert, Marilyn, Onyike, Chiadi, Farrington, Leonie, Rudow, Scott, Brichko, Rottislav, Kielb, Stephanie, Smith, Amanda, Raj, Balebail Ashok, Fargher, Kristin, Sadowski, Martin, Wisniewski, Thomas, Shulman, Melanie, Faustin, Arline, Rao, Julia, Castro, Karen M., Ulysse, Anaztasia, Chen, Shannon, Sheikh, Mohammed O., Singleton-Garvin, Jamika, Petrella, JeffreyR., James, Olga, Wong, Terence Z., Borges-Neto, Salvador, Karlawish, Jason H., Wolk, David A., Vaishnavi, Sanjeev, Clark, Christopher M., Arnold, Steven E., Smith, Charles D., Jicha, Gregory A., Raslau, Flavius D., Lopez, Oscar L., Oakley, MaryAnn, Simpson, Donna M., Porsteinsson, Anton P., Martin, Kim, Kowalski, Nancy, Keltz, Melanie, Goldstein, Bonnie S., Makino, Kelly M., Ismail, M. Saleem, Brand, Connie, Thai, Gaby, Pierce, Aimee, Yanez, Beatriz, Sosa, Elizabeth, Witbracht, Megan, Kelley, Brendan, Nguyen, Trung, Womack, Kyle, Mathews, Dana, Quiceno, Mary, Levey, Allan I., Lah, James J., Hajjar, Ihab, Cellar, Janet S., Burns, Jeffrey M., Swerdlow, Russell H., Brooks, William M., Silverman, Daniel H.S., Kremen, Sarah, Apostolova, Liana, Tingus, Kathleen, Lu, Po H., Bartzokis, George, Woo, Ellen, Teng, Edmond, Graff-Radford, Neill R., Parfitt, Francine, Poki-Walker, Kim, Farlow, Martin R., Hake, Ann Marie, Matthews, Brandy R., Brosch, Jared R., Herring, Scott, van, Christopher H., Mecca, Adam P., Good, Susan P., MacAvoy, Martha G., Carson, Richard E., Varma, Pradeep, Chertkow, Howard, Vaitekunis, Susan, Hosein, Chris, Black, Sandra, Stefanovic, Bojana, Heyn, Chris (Chinthaka), Robin Hsiung, Ging-Yuek, Kim, Ellen, Mudge, Benita, Sossi, Vesna, Feldman, Howard, Assaly, Michele, Finger, Elizabeth, Pasternak, Stephen, Rachinsky, Irina, Kertesz, Andrew, Drost, Dick, Rogers, John, Grant, Ian, Muse, Brittanie, Rogalski, Emily, Robson, Jordan, Mesulam, M.-Marsel, Kerwin, Diana, Wu, Chuang-Kuo, Johnson, Nancy, Lipowski, Kristine, Weintraub, Sandra, Bonakdarpour, Borna, Pomara, Nunzio, Hernando, Raymundo, Sarrael, Antero, Rosen, Howard J., Miller, Bruce L., Perry, David, Turner, Raymond Scott, Johnson, Kathleen, Reynolds, Brigid, MCCann, Kelly, Poe, Jessica, Sperling, Reisa A., Johnson, Keith A., Marshall, Gad A., Yesavage, Jerome, Taylor, Joy L., Chao, Steven, Coleman, Jaila, White, Jessica D., Lane, Barton, Rosen, Allyson, Tinklenberg, Jared, Belden, Christine M., Atri, Alireza, Clark, Kelly A., Zamrini, Edward, Sabbagh, Marwan, Killiany, Ronald, Stern, Robert, Mez, Jesse, Kowall, Neil, Budson, Andrew E., Obisesan, Thomas O., Ntekim, Oyonumo E., Wolday, Saba, Khan, Javed I., Nwulia, Evaristus, Nadarajah, Sheeba, Lerner, Alan, Ogrocki, Paula, Tatsuoka, Curtis, Fatica, Parianne, Maillard, Pauline, Olichney, John, Carmichael, Owen, Bates, Vernice, Capote, Horacio, Rainka, Michelle, Borrie, Michael, Lee, T.-Y., Bartha, Dr Rob, Johnson, Sterling, Asthana, Sanjay, Carlsson, Cynthia M., Perrin, Allison, Burke, Anna, Scharre, Douglas W., Kataki, Maria, Tarawneh, Rawan, Hart, David, Zimmerman, Earl A., Celmins, Dzintra, Miller, Delwyn D., BolesPonto, Laura L., Smith, Karen Ekstam, Koleva, Hristina, Shim, Hyungsub, Nam, Ki Won, Schultz, Susan K., Williamson, Jeff D., Craft, Suzanne, Cleveland, Jo, Yang, Mia, Sink, Kaycee M., Ott, Brian R., Drake, Jonathan, Tremont, Geoffrey, Daiello, Lori A., Drake, Jonathan D., Ritter, Aaron, Bernick, Charles, Munic, Donna, O'Connelll, Abigail, Mintzer, Jacobo, Wiliams, Arthur, Masdeu, Joseph, Shi, Jiong, Garcia, Angelica, Newhouse, Paul, Potkin, Steven, Salloway, Stephen, Malloy, Paul, Correia, Stephen, Kittur, Smita, Pearlson, Godfrey D., Blank, Karen, Anderson, Karen, Flashman, Laura A., Seltzer, Marc, Hynes, Mary L., Santulli, Robert B., Relkin, Norman, Chiang, Gloria, Lee, Athena, Lin, Michael, Ravdin, Lisa, Petersen, Ron, Neylan, Thomas, Grafman, Jordan, Danowski, Sarah, Nguyen-Barrera, Catherine, Hayes, Jacqueline, Finley, Shannon, Bernstein, Matthew, Senjem, Matt, Foster, Norm, Kim, Sungeun, Sood, Ajay, Blanchard, Kimberly S., Fleischman, Debra, Arfanakis, Konstantinos, Varon, Daniel, Greig, Maria T., Petrella, Jeffrey R., Goldstein, Bonnie, Martin, Kimberly S., Reist, Christopher, Sadowsky, Carl, Martinez, Walter, Villena, Teresa, Rosen, Howard, Marshall, Gad, Peskind, Elaine R., Petrie, Eric C., Li, Gail, Mackin, Scott, Jimenez-Maggiora, Gustavo, Drake, Erin, Donohue, Mike, Nelson, Craig, Bickford, David, Butters, Meryl, Zmuda, Michelle, Reyes, Denise, Faber, Kelley M., Nudelman, Kelly N., Au, Yiu Ho, Scherer, Kelly, Catalinotto, Daniel, Stark, Samuel, Ong, Elise, Fernandez, Dariella, Jo, Taeho, Kim, Junpyo, Bice, Paula, Huynh, Kevin, Wang, Tingting, Meikle, Peter J., and Giles, Corey

Published
2023
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4. Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression

Author

MahmoudianDehkordi, Siamak, Ahmed, Ahmed T, Bhattacharyya, Sudeepa, Han, Xianlin, Baillie, Rebecca A, Arnold, Matthias, Skime, Michelle K, John-Williams, Lisa St, Moseley, M Arthur, Thompson, J Will, Louie, Gregory, Riva-Posse, Patricio, Craighead, W Edward, McDonald, William, Krishnan, Ranga, Rush, A John, Frye, Mark A, Dunlop, Boadie W, Weinshilboum, Richard M, and Kaddurah-Daouk, Rima

Subjects
Depression, Brain Disorders, Mental Health, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Mental health, Amines, Antidepressive Agents, Carnitine, Citalopram, Depressive Disorder, Major, Humans, Lipids, Selective Serotonin Reuptake Inhibitors, Mood Disorders Precision Medicine Consortium, Clinical Sciences, Public Health and Health Services, Psychology
Abstract

Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. We used a targeted metabolomics approach utilizing a panel of 180 metabolites to gain insights into mechanisms of action and response to citalopram/escitalopram. Plasma samples from 136 participants with MDD enrolled into the Mayo Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) were profiled at baseline and after 8 weeks of treatment. After treatment, we saw increased levels of short-chain acylcarnitines and decreased levels of medium-chain and long-chain acylcarnitines, suggesting an SSRI effect on β-oxidation and mitochondrial function. Amines-including arginine, proline, and methionine sulfoxide-were upregulated while serotonin and sarcosine were downregulated, suggesting an SSRI effect on urea cycle, one-carbon metabolism, and serotonin uptake. Eighteen lipids within the phosphatidylcholine (PC aa and ae) classes were upregulated. Changes in several lipid and amine levels correlated with changes in 17-item Hamilton Rating Scale for Depression scores (HRSD17). Differences in metabolic profiles at baseline and post-treatment were noted between participants who remitted (HRSD17 ≤ 7) and those who gained no meaningful benefits (

Published
2021

5. Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

Author

Brydges, Christopher R, Fiehn, Oliver, Mayberg, Helen S, Schreiber, Henry, Dehkordi, Siamak Mahmoudian, Bhattacharyya, Sudeepa, Cha, Jungho, Choi, Ki Sueng, Craighead, W Edward, Krishnan, Ranga R, Rush, A John, Dunlop, Boadie W, and Kaddurah-Daouk, Rima

Subjects
Neurosciences, Clinical Research, Complementary and Integrative Health, Anxiety Disorders, Behavioral and Social Science, Mental Health, Depression, Mental health, Adult, Aged, Anxiety, Biomarkers, Brain, Disease Susceptibility, Female, Functional Neuroimaging, Gastrointestinal Microbiome, Humans, Indican, Magnetic Resonance Imaging, Male, Metabolic Networks and Pathways, Metabolome, Metabolomics, Middle Aged, Symptom Assessment, Uremic Toxins, Young Adult, Mood Disorders Precision Medicine Consortium
Abstract

It is unknown whether indoles, metabolites of tryptophan that are derived entirely from bacterial metabolism in the gut, are associated with symptoms of depression and anxiety. Serum samples (baseline, 12 weeks) were drawn from participants (n = 196) randomized to treatment with cognitive behavioral therapy (CBT), escitalopram, or duloxetine for major depressive disorder. Baseline indoxyl sulfate abundance was positively correlated with severity of psychic anxiety and total anxiety and with resting state functional connectivity to a network that processes aversive stimuli (which includes the subcallosal cingulate cortex (SCC-FC), bilateral anterior insula, right anterior midcingulate cortex, and the right premotor areas). The relation between indoxyl sulfate and psychic anxiety was mediated only through the metabolite's effect on the SCC-FC with the premotor area. Baseline indole abundances were unrelated to post-treatment outcome measures, and changes in symptoms were not correlated with changes in indole concentrations. These results suggest that CBT and antidepressant medications relieve anxiety via mechanisms unrelated to modulation of indoles derived from gut microbiota; it remains possible that treatment-related improvement stems from their impact on other aspects of the gut microbiome. A peripheral gut microbiome-derived metabolite was associated with altered neural processing and with psychiatric symptom (anxiety) in humans, which provides further evidence that gut microbiome disruption can contribute to neuropsychiatric disorders that may require different therapeutic approaches. Given the exploratory nature of this study, findings should be replicated in confirmatory studies.Clinical trial NCT00360399 "Predictors of Antidepressant Treatment Response: The Emory CIDAR" https://clinicaltrials.gov/ct2/show/NCT00360399 .

Published
2021

7. Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes

Author

Ahmed, Ahmed T., MahmoudianDehkordi, Siamak, Bhattacharyya, Sudeepa, Arnold, Matthias, Liu, Duan, Neavin, Drew, Moseley, M. Arthur, Thompson, J. Will, Williams, Lisa St John, Louie, Gregory, Skime, Michelle K., Wang, Liewei, Riva-Posse, Patricio, McDonald, William M., Bobo, William V., Craighead, W. Edward, Krishnan, Ranga, Weinshilboum, Richard M., Dunlop, Boadie W., Millington, David S., Rush, A. John, Frye, Mark A., and Kaddurah-Daouk, Rima

Published
2020
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8. Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease

Author

Liang, Nuanyi, Nho, Kwangsik, Newman, John W., Arnold, Matthias, Huynh, Kevin, Meikle, Peter J., Borkowski, Kamil, Kaddurah-Daouk, Rima, Kueider-Paisley, Alexandra, Doraiswamy, P. Murali, Blach, Colette, Moseley, Arthur, Mahmoudiandehkhordi, Siamak, Welsh-Balmer, Kathleen, Plassman, Brenda, Saykin, Andrew, Risacher, Shannon, Kastenmüller, Gabi, Han, Xianlin, Baillie, Rebecca, Knight, Rob, Dorrestein, Pieter, Brewer, James, Mayer, Emeran, Labus, Jennifer, Baldi, Pierre, Gupta, Arpana, Fiehn, Oliver, Barupal, Dinesh, Meikle, Peter, Mazmanian, Sarkis, Rader, Dan, Shaw, Leslie, van Duijin, Cornelia, Amin, Najaf, Nevado-Holgado, Alejo, Bennett, David, Krishnan, Ranga, Keshavarzian, Ali, Vogt, Robin, Ikram, Arfan, Hankemeier, Thomas, Thiele, Ines, Funk, Cory, Baloni, Priyanka, Jia, Wei, Wishart, David, Brinton, Roberta, Farrer, Lindsay, Au, Rhoda, Liang, Nuanyi, Nho, Kwangsik, Newman, John W., Arnold, Matthias, Huynh, Kevin, Meikle, Peter J., Borkowski, Kamil, Kaddurah-Daouk, Rima, Kueider-Paisley, Alexandra, Doraiswamy, P. Murali, Blach, Colette, Moseley, Arthur, Mahmoudiandehkhordi, Siamak, Welsh-Balmer, Kathleen, Plassman, Brenda, Saykin, Andrew, Risacher, Shannon, Kastenmüller, Gabi, Han, Xianlin, Baillie, Rebecca, Knight, Rob, Dorrestein, Pieter, Brewer, James, Mayer, Emeran, Labus, Jennifer, Baldi, Pierre, Gupta, Arpana, Fiehn, Oliver, Barupal, Dinesh, Meikle, Peter, Mazmanian, Sarkis, Rader, Dan, Shaw, Leslie, van Duijin, Cornelia, Amin, Najaf, Nevado-Holgado, Alejo, Bennett, David, Krishnan, Ranga, Keshavarzian, Ali, Vogt, Robin, Ikram, Arfan, Hankemeier, Thomas, Thiele, Ines, Funk, Cory, Baloni, Priyanka, Jia, Wei, Wishart, David, Brinton, Roberta, Farrer, Lindsay, and Au, Rhoda

Abstract

Inflammation is an important factor in Alzheimer’s disease (AD). An NMR measurement in plasma, glycoprotein acetyls (GlycA), captures the overall level of protein production and glycosylation implicated in systemic inflammation. With its additional advantage of reducing biological variability, GlycA might be useful in monitoring the relationship between peripheral inflammation and brain changes relevant to AD. However, the associations between GlycA and these brain changes have not been fully evaluated. Here, we performed Spearman’s correlation analyses to evaluate these associations cross-sectionally and determined whether GlycA can inform AD-relevant longitudinal measurements among participants in the Alzheimer’s Disease Neuroimaging Initiative (n = 1506), with additional linear models and stratification analyses to evaluate the influences of sex or diagnosis status and confirm findings from Spearman’s correlation analyses. We found that GlycA was elevated in AD patients compared to cognitively normal participants. GlycA correlated negatively with multiple concurrent regional brain volumes in females diagnosed with late mild cognitive impairment (LMCI) or AD. Baseline GlycA level was associated with executive function decline at 3–9 year follow-up in participants diagnosed with LMCI at baseline, with similar but not identical trends observed in the future decline of memory and entorhinal cortex volume. Results here indicated that GlycA is an inflammatory biomarker relevant to AD pathogenesis and that the stage of LMCI might be relevant to inflammation-related intervention.

Published
2024

9. Incubating the Research Independence of a Medical Scientist Training Program Graduate

Author

Dzirasa, Kafui, Krishnan, Ranga R, and Williams, R Sanders

Subjects
Clinical Research, Biomedical Research, Education, Medical, Graduate, Feasibility Studies, Humans, Mentors, National Institutes of Health (U.S.), Professional Autonomy, Psychiatry, Training Support, United States, Clinical Sciences, Curriculum and Pedagogy, General & Internal Medicine
Abstract

ProblemPhysician-scientists play a critical role in discovering new biological knowledge and translating findings into medical practices that can improve clinical outcomes. Collectively, the National Institutes of Health (NIH) and its affiliated Medical Scientist Training Programs (MSTPs) invest upwards of $500,000 to fully train each of the 900+ MD/PhD students enrolled in these programs. Nevertheless, graduates face the challenges of navigating fragmented intervals of clinical training and research engagement, reinitiating research upon completing their residencies, managing financial pressures, and competing for funding following what is typically four or more years of research inactivity. Together, these barriers contribute to the high attrition rate of MSTP graduates from research careers.ApproachThe authors designed and implemented (2009-2014), for a single trainee, an alternative postgraduate training model characterized by early research engagement, strategic mentoring, unyoked clinical and research milestones, and dedicated financial support.OutcomesThe pilot training experiment was so successful that the trainee secured an NIH project grant and completed his transition to research independence 3.5 years after starting the experimental training schedule-nearly 9 years earlier (based on age) than is typical for MD/PhDs transitioning from mentored to independent research. This success has demonstrated that unyoking research engagement from conventional calendar-based clinical training milestones is a feasible, effective means of incubating research independence in MSTP graduates.Next stepsThe authors encourage the design and application of similar unconventional approaches that interweave residency training with ongoing research activity for appropriate candidates, especially in subspecialties with increased MSTP graduate enrollment.

Published
2015

11. Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data

Author

Jo, Taeho, primary, Kim, Junpyo, additional, Bice, Paula, additional, Huynh, Kevin, additional, Wang, Tingting, additional, Arnold, Matthias, additional, Meikle, Peter J., additional, Giles, Corey, additional, Kaddurah-Daouk, Rima, additional, Saykin, Andrew J., additional, Nho, Kwangsik, additional, Kueider-Paisley, Alexandra, additional, Doraiswamy, P. Murali, additional, Blach, Colette, additional, Moseley, Arthur, additional, Thompson, Will, additional, St John-Williams, Lisa, additional, Mahmoudiandehkhordi, Siamak, additional, Tenenbaum, Jessica, additional, Welsh-Balmer, Kathleen, additional, Plassman, Brenda, additional, Risacher, Shannon L., additional, Kastenmüller, Gabi, additional, Han, Xianlin, additional, Baillie, Rebecca, additional, Knight, Rob, additional, Dorrestein, Pieter, additional, Brewer, James, additional, Mayer, Emeran, additional, Labus, Jennifer, additional, Baldi, Pierre, additional, Gupta, Arpana, additional, Fiehn, Oliver, additional, Barupal, Dinesh, additional, Meikle, Peter, additional, Mazmanian, Sarkis, additional, Rader, Dan, additional, Kling, Mitchel, additional, Shaw, Leslie, additional, Trojanowski, John, additional, van Duijin, Cornelia, additional, Nevado-Holgado, Alejo, additional, Bennett, David, additional, Krishnan, Ranga, additional, Keshavarzian, Ali, additional, Vogt, Robin, additional, Ikram, Arfan, additional, Hankemeier, Thomas, additional, Thiele, Ines, additional, Price, Nathan, additional, Funk, Cory, additional, Baloni, Priyanka, additional, Jia, Wei, additional, Wishart, David, additional, Brinton, Roberta, additional, Chang, Rui, additional, Farrer, Lindsay, additional, Au, Rhoda, additional, Qiu, Wendy, additional, Würtz, Peter, additional, Koal, Therese, additional, Mangravite, Lara, additional, Krumsiek, Jan, additional, Suhre, Karsten, additional, Newman, John, additional, Moreno, Herman, additional, Foroud, Tatania, additional, Sacks, Frank, additional, Jansson, Janet, additional, Weiner, Michael W., additional, Aisen, Paul, additional, Petersen, Ronald, additional, Jack, Clifford R., additional, Jagust, William, additional, Trojanowki, John Q., additional, Toga, Arthur W., additional, Beckett, Laurel, additional, Green, Robert C., additional, Morris, John C., additional, Perrin, Richard J., additional, Shaw, Leslie M., additional, Khachaturian, Zaven, additional, Carrillo, Maria, additional, Potter, William, additional, Barnes, Lisa, additional, Bernard, Marie, additional, Gonzalez, Hector, additional, Ho, Carole, additional, Hsiao, John K., additional, Jackson, Jonathan, additional, Masliah, Eliezer, additional, Masterman, Donna, additional, Okonkwo, Ozioma, additional, Perrin, Richard, additional, Ryan, Laurie, additional, Silverberg, Nina, additional, Fleisher, Adam, additional, Sacrey, Diana Truran, additional, Fockler, Juliet, additional, Conti, Cat, additional, Veitch, Dallas, additional, Neuhaus, John, additional, Jin, Chengshi, additional, Nosheny, Rachel, additional, Ashford, Miriam, additional, Flenniken, Derek, additional, Kormos, Adrienne, additional, Montine, Tom, additional, Rafii, Michael, additional, Raman, Rema, additional, Jimenez, Gustavo, additional, Donohue, Michael, additional, Gessert, Devon, additional, Salazar, Jennifer, additional, Zimmerman, Caileigh, additional, Cabrera, Yuliana, additional, Walter, Sarah, additional, Miller, Garrett, additional, Coker, Godfrey, additional, Clanton, Taylor, additional, Hergesheimer, Lindsey, additional, Smith, Stephanie, additional, Adegoke, Olusegun, additional, Mahboubi, Payam, additional, Moore, Shelley, additional, Pizzola, Jeremy, additional, Shaffer, Elizabeth, additional, Sloan, Brittany, additional, Harvey, Danielle, additional, Forghanian-Arani, Arvin, additional, Borowski, Bret, additional, Ward, Chad, additional, Schwarz, Christopher, additional, Jones, David, additional, Gunter, Jeff, additional, Kantarci, Kejal, additional, Senjem, Matthew, additional, Vemuri, Prashanthi, additional, Reid, Robert, additional, Fox, Nick C., additional, Malone, Ian, additional, Thompson, Paul, additional, Thomopoulos, Sophia I., additional, Nir, Talia M., additional, Jahanshad, Neda, additional, DeCarli, Charles, additional, Knaack, Alexander, additional, Fletcher, Evan, additional, Tosun-Turgut, Duygu, additional, Chen, Stephanie Rossi, additional, Choe, Mark, additional, Crawford, Karen, additional, Yushkevich, Paul A., additional, Das, Sandhitsu, additional, Koeppe, Robert A., additional, Reiman, Eric M., additional, Chen, Kewei, additional, Mathis, Chet, additional, Landau, Susan, additional, Cairns, Nigel J., additional, Householder, Erin, additional, Franklin, Erin, additional, Bernhardt, Haley, additional, Taylor-Reinwald, Lisa, additional, Korecka, Magdalena, additional, Figurski, Michal, additional, Neu, Scott, additional, Apostolova, Liana G., additional, Shen, Li, additional, Foroud, Tatiana M., additional, Nudelman, Kelly, additional, Faber, Kelley, additional, Wilmes, Kristi, additional, Thal, Leon, additional, Silbert, Lisa C., additional, Lind, Betty, additional, Crissey, Rachel, additional, Kaye, Jeffrey A., additional, Carter, Raina, additional, Dolen, Sara, additional, Quinn, Joseph, additional, Schneider, Lon S., additional, Pawluczyk, Sonia, additional, Becerra, Mauricio, additional, Teodoro, Liberty, additional, Dagerman, Karen, additional, Spann, Bryan M., additional, Vanderswag, Helen, additional, Ziolkowski, Jaimie, additional, Heidebrink, Judith L., additional, Zbizek-Nulph, Lisa, additional, Lord, Joanne L., additional, Mason, Sara S., additional, Albers, Colleen S., additional, Knopman, David, additional, Johnson, Kris, additional, Villanueva-Meyer, Javier, additional, Pavlik, Valory, additional, Pacini, Nathaniel, additional, Lamb, Ashley, additional, Kass, Joseph S., additional, Doody, Rachelle S., additional, Shibley, Victoria, additional, Chowdhury, Munir, additional, Rountree, Susan, additional, Dang, Mimi, additional, Stern, Yaakov, additional, Honig, Lawrence S., additional, Mintz, Akiva, additional, Ances, Beau, additional, Winkfield, David, additional, Carroll, Maria, additional, Stobbs-Cucchi, Georgia, additional, Oliver, Angela, additional, Creech, Mary L., additional, Mintun, Mark A., additional, Schneider, Stacy, additional, Geldmacher, David, additional, Love, Marissa Natelson, additional, Griffith, Randall, additional, Clark, David, additional, Brockington, John, additional, Marson, Daniel, additional, Grossman, Hillel, additional, Goldstein, Martin A., additional, Greenberg, Jonathan, additional, Mitsis, Effie, additional, Shah, Raj C., additional, Lamar, Melissa, additional, Samuels, Patricia, additional, Duara, Ranjan, additional, Greig-Custo, Maria T., additional, Rodriguez, Rosemarie, additional, Albert, Marilyn, additional, Onyike, Chiadi, additional, Farrington, Leonie, additional, Rudow, Scott, additional, Brichko, Rottislav, additional, Kielb, Stephanie, additional, Smith, Amanda, additional, Raj, Balebail Ashok, additional, Fargher, Kristin, additional, Sadowski, Martin, additional, Wisniewski, Thomas, additional, Shulman, Melanie, additional, Faustin, Arline, additional, Rao, Julia, additional, Castro, Karen M., additional, Ulysse, Anaztasia, additional, Chen, Shannon, additional, Sheikh, Mohammed O., additional, Singleton-Garvin, Jamika, additional, Petrella, JeffreyR., additional, James, Olga, additional, Wong, Terence Z., additional, Borges-Neto, Salvador, additional, Karlawish, Jason H., additional, Wolk, David A., additional, Vaishnavi, Sanjeev, additional, Clark, Christopher M., additional, Arnold, Steven E., additional, Smith, Charles D., additional, Jicha, Gregory A., additional, Raslau, Flavius D., additional, Lopez, Oscar L., additional, Oakley, MaryAnn, additional, Simpson, Donna M., additional, Porsteinsson, Anton P., additional, Martin, Kim, additional, Kowalski, Nancy, additional, Keltz, Melanie, additional, Goldstein, Bonnie S., additional, Makino, Kelly M., additional, Ismail, M. Saleem, additional, Brand, Connie, additional, Thai, Gaby, additional, Pierce, Aimee, additional, Yanez, Beatriz, additional, Sosa, Elizabeth, additional, Witbracht, Megan, additional, Kelley, Brendan, additional, Nguyen, Trung, additional, Womack, Kyle, additional, Mathews, Dana, additional, Quiceno, Mary, additional, Levey, Allan I., additional, Lah, James J., additional, Hajjar, Ihab, additional, Cellar, Janet S., additional, Burns, Jeffrey M., additional, Swerdlow, Russell H., additional, Brooks, William M., additional, Silverman, Daniel H.S., additional, Kremen, Sarah, additional, Apostolova, Liana, additional, Tingus, Kathleen, additional, Lu, Po H., additional, Bartzokis, George, additional, Woo, Ellen, additional, Teng, Edmond, additional, Graff-Radford, Neill R., additional, Parfitt, Francine, additional, Poki-Walker, Kim, additional, Farlow, Martin R., additional, Hake, Ann Marie, additional, Matthews, Brandy R., additional, Brosch, Jared R., additional, Herring, Scott, additional, van, Christopher H., additional, Mecca, Adam P., additional, Good, Susan P., additional, MacAvoy, Martha G., additional, Carson, Richard E., additional, Varma, Pradeep, additional, Chertkow, Howard, additional, Vaitekunis, Susan, additional, Hosein, Chris, additional, Black, Sandra, additional, Stefanovic, Bojana, additional, Heyn, Chris (Chinthaka), additional, Robin Hsiung, Ging-Yuek, additional, Kim, Ellen, additional, Mudge, Benita, additional, Sossi, Vesna, additional, Feldman, Howard, additional, Assaly, Michele, additional, Finger, Elizabeth, additional, Pasternak, Stephen, additional, Rachinsky, Irina, additional, Kertesz, Andrew, additional, Drost, Dick, additional, Rogers, John, additional, Grant, Ian, additional, Muse, Brittanie, additional, Rogalski, Emily, additional, Robson, Jordan, additional, Mesulam, M.-Marsel, additional, Kerwin, Diana, additional, Wu, Chuang-Kuo, additional, Johnson, Nancy, additional, Lipowski, Kristine, additional, Weintraub, Sandra, additional, Bonakdarpour, Borna, additional, Pomara, Nunzio, additional, Hernando, Raymundo, additional, Sarrael, Antero, additional, Rosen, Howard J., additional, Miller, Bruce L., additional, Perry, David, additional, Turner, Raymond Scott, additional, Johnson, Kathleen, additional, Reynolds, Brigid, additional, MCCann, Kelly, additional, Poe, Jessica, additional, Sperling, Reisa A., additional, Johnson, Keith A., additional, Marshall, Gad A., additional, Yesavage, Jerome, additional, Taylor, Joy L., additional, Chao, Steven, additional, Coleman, Jaila, additional, White, Jessica D., additional, Lane, Barton, additional, Rosen, Allyson, additional, Tinklenberg, Jared, additional, Belden, Christine M., additional, Atri, Alireza, additional, Clark, Kelly A., additional, Zamrini, Edward, additional, Sabbagh, Marwan, additional, Killiany, Ronald, additional, Stern, Robert, additional, Mez, Jesse, additional, Kowall, Neil, additional, Budson, Andrew E., additional, Obisesan, Thomas O., additional, Ntekim, Oyonumo E., additional, Wolday, Saba, additional, Khan, Javed I., additional, Nwulia, Evaristus, additional, Nadarajah, Sheeba, additional, Lerner, Alan, additional, Ogrocki, Paula, additional, Tatsuoka, Curtis, additional, Fatica, Parianne, additional, Maillard, Pauline, additional, Olichney, John, additional, Carmichael, Owen, additional, Bates, Vernice, additional, Capote, Horacio, additional, Rainka, Michelle, additional, Borrie, Michael, additional, Lee, T.-Y., additional, Bartha, Dr Rob, additional, Johnson, Sterling, additional, Asthana, Sanjay, additional, Carlsson, Cynthia M., additional, Perrin, Allison, additional, Burke, Anna, additional, Scharre, Douglas W., additional, Kataki, Maria, additional, Tarawneh, Rawan, additional, Hart, David, additional, Zimmerman, Earl A., additional, Celmins, Dzintra, additional, Miller, Delwyn D., additional, BolesPonto, Laura L., additional, Smith, Karen Ekstam, additional, Koleva, Hristina, additional, Shim, Hyungsub, additional, Nam, Ki Won, additional, Schultz, Susan K., additional, Williamson, Jeff D., additional, Craft, Suzanne, additional, Cleveland, Jo, additional, Yang, Mia, additional, Sink, Kaycee M., additional, Ott, Brian R., additional, Drake, Jonathan, additional, Tremont, Geoffrey, additional, Daiello, Lori A., additional, Drake, Jonathan D., additional, Ritter, Aaron, additional, Bernick, Charles, additional, Munic, Donna, additional, O'Connelll, Abigail, additional, Mintzer, Jacobo, additional, Wiliams, Arthur, additional, Masdeu, Joseph, additional, Shi, Jiong, additional, Garcia, Angelica, additional, Newhouse, Paul, additional, Potkin, Steven, additional, Salloway, Stephen, additional, Malloy, Paul, additional, Correia, Stephen, additional, Kittur, Smita, additional, Pearlson, Godfrey D., additional, Blank, Karen, additional, Anderson, Karen, additional, Flashman, Laura A., additional, Seltzer, Marc, additional, Hynes, Mary L., additional, Santulli, Robert B., additional, Relkin, Norman, additional, Chiang, Gloria, additional, Lee, Athena, additional, Lin, Michael, additional, Ravdin, Lisa, additional, Petersen, Ron, additional, Neylan, Thomas, additional, Grafman, Jordan, additional, Danowski, Sarah, additional, Nguyen-Barrera, Catherine, additional, Hayes, Jacqueline, additional, Finley, Shannon, additional, Bernstein, Matthew, additional, Senjem, Matt, additional, Foster, Norm, additional, Kim, Sungeun, additional, Sood, Ajay, additional, Blanchard, Kimberly S., additional, Fleischman, Debra, additional, Arfanakis, Konstantinos, additional, Varon, Daniel, additional, Greig, Maria T., additional, Petrella, Jeffrey R., additional, Goldstein, Bonnie, additional, Martin, Kimberly S., additional, Reist, Christopher, additional, Sadowsky, Carl, additional, Martinez, Walter, additional, Villena, Teresa, additional, Rosen, Howard, additional, Marshall, Gad, additional, Peskind, Elaine R., additional, Petrie, Eric C., additional, Li, Gail, additional, Mackin, Scott, additional, Jimenez-Maggiora, Gustavo, additional, Drake, Erin, additional, Donohue, Mike, additional, Nelson, Craig, additional, Bickford, David, additional, Butters, Meryl, additional, Zmuda, Michelle, additional, Reyes, Denise, additional, Faber, Kelley M., additional, Nudelman, Kelly N., additional, Au, Yiu Ho, additional, Scherer, Kelly, additional, Catalinotto, Daniel, additional, Stark, Samuel, additional, Ong, Elise, additional, and Fernandez, Dariella, additional

Published
2023
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12. Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

Author

Ahmed, Ahmed T., Frye, Mark A., Rush, A John, Biernacka, Joanna M., Craighead, W. Edward, McDonald, William M., Bobo, William V., Riva-Posse, Patricio, Tye, Susannah J., Mayberg, Helen S., Hall-Flavin, Daniel K., Skime, Michelle K., Jenkins, Greg D., Wang, Liewei, Krishnan, Ranga Rama, Weinshilboum, Richard M., Kaddurah-Daouk, Rima, and Dunlop, Boadie W.

Published
2018
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13. Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway.

Author

Zhu, Hongjie, Bogdanov, Mikhail B, Boyle, Stephen H, Matson, Wayne, Sharma, Swati, Matson, Samantha, Churchill, Erik, Fiehn, Oliver, Rush, John A, Krishnan, Ranga R, Pickering, Eve, Delnomdedieu, Marielle, Kaddurah-Daouk, Rima, and Pharmacometabolomics Research Network

Subjects
Pharmacometabolomics Research Network, Humans, Sertraline, Indoles, Serotonin Uptake Inhibitors, Placebos, Double-Blind Method, Depressive Disorder, Major, Adolescent, Adult, Middle Aged, Metabolomics, Young Adult, Depressive Disorder, Major, General Science & Technology
Abstract

Therapeutic response to selective serotonin (5-HT) reuptake inhibitors in Major Depressive Disorder (MDD) varies considerably among patients, and the onset of antidepressant therapeutic action is delayed until after 2 to 4 weeks of treatment. The objective of this study was to analyze changes within methoxyindole and kynurenine (KYN) branches of tryptophan pathway to determine whether differential regulation within these branches may contribute to mechanism of variation in response to treatment. Metabolomics approach was used to characterize early biochemical changes in tryptophan pathway and correlated biochemical changes with treatment outcome. Outpatients with MDD were randomly assigned to sertraline (n = 35) or placebo (n = 40) in a double-blind 4-week trial; response to treatment was measured using the 17-item Hamilton Rating Scale for Depression (HAMD17). Targeted electrochemistry based metabolomic platform (LCECA) was used to profile serum samples from MDD patients. The response rate was slightly higher for sertraline than for placebo (21/35 [60%] vs. 20/40 [50%], respectively, χ(2)(1)  = 0.75, p = 0.39). Patients showing a good response to sertraline had higher pretreatment levels of 5-methoxytryptamine (5-MTPM), greater reduction in 5-MTPM levels after treatment, an increase in 5-Methoxytryptophol (5-MTPOL) and Melatonin (MEL) levels, and decreases in the (KYN)/MEL and 3-Hydroxykynurenine (3-OHKY)/MEL ratios post-treatment compared to pretreatment. These changes were not seen in the patients showing poor response to sertraline. In the placebo group, more favorable treatment outcome was associated with increases in 5-MTPOL and MEL levels and significant decreases in the KYN/MEL and 3-OHKY/MEL; changes in 5-MTPM levels were not associated with the 4-week response. These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.

Published
2013

29. Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial

Author

Sheline, Yvette I., Pieper, Carl F., Barch, Deanna M., Welsh-Boehmer, Kathleen, McKinstry, Robert C., MacFall, James R., D'Angelo, Gina, Garcia, Keith S., Gersing, Kenneth, Wilkins, Consuelo, Taylor, Warren, Steffens, David C., Krishnan, Ranga R., and Doraiswamy, P. Murali

Subjects
Depression in old age -- Development and progression, Depression in old age -- Research, Depression in old age -- Risk factors, Executive function (Psychology) -- Research, Basal ganglia -- Physiological aspects, Basal ganglia -- Research, Health, Psychology and mental health
Published
2010

33. Perspectives on depression, mild cognitive impairment, and cognitive decline

Author

Steffens, David C., Otey, Emeline, Alexopoulos, George S., Butters, Meryl A., Cuthbert, Bruce, Ganguli, Mary, Geda, Yonas E., Hendrie, Hugh C., Krishnan, Ranga R., Kumar, Anand, Lopez, Oscar L., Lyketsos, Constantine G., Mast, Benjamin T., Morris, John C., Norton, Maria C., Peavy, Guerry M., Petersen, Ronald C., Reynolds, Charles F., Salloway, Stephen, Welsh-Bohmer, Kathleen A., and Yesavage, Jerome

Subjects
Depression in old age -- Research, Cognition disorders in old age -- Research, Health, Psychology and mental health
Published
2006

34. Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial

Author

Tyring, Stephen, Gottlieb, Alice, Papp, Kim, Gordon, Ken, Leonardi, Craig, Wang, Andrea, Lalla, Deepa, Woolley, Michael, Jahreis, Angelika, Zitnik, Ralph, Cella, David, and Krishnan, Ranga

Subjects
Psoriasis -- Drug therapy, Cytokines -- Physiological aspects, Etanercept -- Dosage and administration, Etanercept -- Patient outcomes, Etanercept -- Product development, Clinical trials -- Management, Company business management
Published
2006

36. Depression and ischemic heart disease: What have we learned so far and what must we do in the future?

Author

Jiang, Wei, Glassman, Alexander, Krishnan, Ranga, O'Connor, Christopher M., and Califf, Robert M.

Subjects
Heart diseases, Depression, Mental, Ischemia, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.04.012 Byline: Wei Jiang (a), Alexander Glassman (b), Ranga Krishnan (c), Christopher M. O'Connor (d), Robert M. Califf (e) Author Affiliation: (a) Department of Internal Medicine and Psychiatry and Behavioral Sciences, Duke University, Medical Center, Durham, NC (b) Department of Clinical Psychopharmacology, New York State Psychiatric Institute, New York, NY (c) Division of Biological Psychiatry, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC (d) Department of Medicine, Duke University Medical Center, Durham, NC (e) Duke Clinical Research Institute, Durham, NC Article History: Received 18 April 2005; Accepted 18 April 2005 Article Note: (footnote) Sponsors: Aventis Pharmaceuticals, Inc; Forest Laboratories, Inc; GlaxoSmithKline; Pfizer, Inc; and Wyeth-Ayerst Pharmaceuticals.

Published
2005

37. Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction

Author

Taylor, C. Barr, Youngblood, Marston E., Catellier, Diane, Veith, Richard C., Carney, Robert M., Burg, Matthew M., Kaufmann, Peter G., Shuster, John, Mellman, Thomas, Blumenthal, James A., Krishnan, Ranga, and Jaffe, Allan S.

Subjects
Drug therapy -- Patient outcomes, Heart attack -- Prognosis, Depression, Mental -- Drug therapy, Antidepressants -- Dosage and administration, Health, Psychology and mental health
Published
2005

38. The child and adolescent psychiatry trials network (CAPTN)

Author

March, John S., Silva, Susan G., Compton, Scott, Anthony, Ginger, DeVeaugh-Geiss, Joseph, Califf, Robert, and Krishnan, Ranga

Subjects
Child psychiatry -- Research, Adolescent psychiatry -- Research, Clinical trials, Family and marriage, Psychology and mental health
Published
2004

41. Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT)

Author

Meltzer, Herbert Y., Alphs, Larry, Green, Alan I., Altamura, A. Carlo, Anand, Ravi, Bertoldi, Alberto, Bourgeois, Marc, Chouinard, Guy, Islam, M. Zahur, Kane, John, Krishnan, Ranga, Lindenmayer, J.-P., and Potkin, Steven

Subjects
Suicide -- Prevention, Schizophrenia -- Drug therapy, Clozapine -- Evaluation, Health, Psychology and mental health, Clozaril (Medication) -- Evaluation
Published
2003

44. Contributors

Author

Ackerman, Michael J., primary, Anderson, Matthew L., additional, Andreotti, Felicita, additional, Annex, Brian H., additional, Antonellis, Anthony, additional, Artemov, Dmitri, additional, Bain, James R., additional, Barnes, Peter J., additional, Barnholtz-Sloan, J.S., additional, Becker, Richard C., additional, Benjamin, Ivor J., additional, Billings, Paul R., additional, Body, Simon C., additional, Boguski, Mark, additional, Bonassi, Stefano, additional, Bondy, Brigitta, additional, Bos, J. Martijn, additional, Breitbart, Roger E., additional, Brody, Jerome, additional, Brown, Matthew P., additional, Bullinger, Lars, additional, Burgess, Shawn C., additional, Butte, Atul J., additional, Carey, David J., additional, Carlson, George, additional, Celedón, Juan C., additional, Chandrasekharan, Subhashini, additional, Chang, Wing C. (John), additional, Chen, Yan, additional, Chiocca, Antonio, additional, Chow, Theresa Puifun, additional, Chung, Wendy K., additional, Cook-Deegan, Robert, additional, Corella, Dolores, additional, Cottrell, Susan, additional, Cox, Nancy J., additional, Crawford, Nigel P.S., additional, Cuticchia, A. Jamie, additional, Deforce, Dieter, additional, Deng, Mario C., additional, Devi, Gayathri, additional, deVos, Theo, additional, Distler, Juergen, additional, Dohner, Harmut, additional, Dokun, Ayotunde O., additional, Edbrooke, Mark R., additional, Edelman, Lucas B., additional, Elewaut, Dirk, additional, Epstein, Charles J., additional, Fanous, Ayman H., additional, Febbo, Phillip G., additional, Feezor, Robert J., additional, Feng, Yonmei, additional, Földes-Papp, Zeno, additional, Fujinaka, Hidehiko, additional, Galas, David J., additional, Garrison, Louis, P., additional, Gerhard, Glenn S., additional, Ginsburg, Geoffrey S., additional, Gjertsen, Bjorn T., additional, Glass, Michael, additional, Goldstein, David B., additional, Gordon, Erynn S., additional, Gosnell, Tucker, additional, Grass, Peter, additional, Green, Eric D., additional, Grossman, Iris, additional, Gwinn, Marta, additional, Haefliger, Carolina, additional, Haga, Susanne B., additional, Hall, Per, additional, Hare, Joshua M., additional, Hariri, Ahmad, additional, Heath, James R., additional, Hegele, Robert A., additional, Heidecker, Bettina, additional, Hislop, Shona, additional, Hoffman, Eric P., additional, Holton, John, additional, Hood, Leroy, additional, Huang, Andrew T., additional, Huang, Erich S., additional, Hubbard, Carlos A., additional, Hunter, Kent, additional, Hyland, Courtney, additional, Ihm, Chunhwa, additional, Ilkayeva, Olga, additional, Irizarry, Rafael, additional, Jain, Shushant, additional, Johnson, Melissa D., additional, Kantoff, Philip W., additional, Kathiresan, Sekar, additional, Kathuria, Hasmeena, additional, Kawamoto, Kensaku, additional, Keyser, Filip De, additional, Khalid, Asif, additional, Khoury, Muin, additional, Kingsmore, Stephen F., additional, Kittleson, Michelle M., additional, Koshy, Beena T., additional, Krishnan, Ranga, additional, Krouse, Robert S., additional, Kundra, Vikas, additional, Lai-Goldman, Myla, additional, Lakhani, Vipul, additional, Langer, Robert, additional, Lawler, Sean E., additional, Lee, Inyoul, additional, Lee, Charles, additional, Lee, Arthur S., additional, Leong, Stanely, additional, Lesche, Ralf, additional, Levy, Samuel, additional, Liu, Edison T., additional, Lobach, David F., additional, Lorens, James B., additional, Lusis, Aldons J., additional, Lyerly, H. Kim, additional, Madamanchi, Nageswara R., additional, Martinez, J. Alfredo, additional, Masignani, Vega, additional, McGrath, Kevin, additional, McHutchison, John, additional, Middleton, Frank, additional, Mielants, Herman, additional, Muehlbauer, Michael J., additional, Müller-Ladner, Ulf, additional, Nelson, Mark A., additional, Neri, Monica, additional, Netea, Mihai, additional, Newby, L. Kristin, additional, Newgard, Christopher B., additional, Ng, Maggie, additional, Noble, Paul W., additional, Ntziachristos, Vasilis, additional, Nussbaum, Robert L., additional, O'Donoghue, Meghan B., additional, Odunsi, Kunle, additional, Olden, Kenneth, additional, Ommen, Steve R., additional, Ordovas, Jose M., additional, Patarca, Roberto, additional, Patel, Jeetendra, additional, Patel, K., additional, Pato, Carlos N., additional, Pato, Michele T., additional, Pejovic, Tanja, additional, Perin, Noah C., additional, Pham, Michael, additional, Plenge, Robert M., additional, Plum, Achim, additional, Podgoreanu, Mihai V., additional, Pollack, Jonathan R., additional, Pollex, Rebecca L., additional, Price, Nathan D., additional, Quertermous, Thomas, additional, Quintana, Francisco J., additional, Raby, Benjamin A., additional, Rader, Daniel J., additional, Ramaswamy, Sridhar, additional, Rammensee, Hans-Georg, additional, Ramsey, Scott D., additional, Rappuoli, Rino, additional, Rifai, Nader, additional, Rimsza, Lisa, additional, Rogers, Yu-Hui, additional, Roses, Allen D., additional, Ross, Jeffrey S., additional, Roubenoff, Ronenn, additional, Runge, Marschall S., additional, Scheuner, Maren T., additional, Schuster, Matthias, additional, Schwartz, David A., additional, Schwinn, Debra A., additional, Seng, Chia Kee, additional, Shackel, Nicholas A., additional, Shannon, M. Frances, additional, Sherry, A. Dean, additional, Shi, Jiaqi, additional, Shianna, Kevin, additional, Shnayder, Yelizaveta, additional, Singleton, Andrew B., additional, Slavin, T.P., additional, Smith, Desmond J., additional, Snoeckx, Rikkert L., additional, Snyderman, Ralph, additional, Spira, Avrum, additional, Spraggs, Colin F., additional, Stevens, Robert D., additional, Stewart, Nicolas A., additional, Stewart, Alison, additional, Stewart, F., additional, Strausberg, Robert L., additional, Szyf, Moshe, additional, Tan, Weihong, additional, Tepper, Robert I., additional, Tettelin, Hervé, additional, Thomas, Giovana R., additional, Thompson, John D., additional, Thongboonkerd, Visith, additional, Topol, Eric J., additional, Towbin, Jeffrey A., additional, Bodegraven, Ad A. van, additional, Van Den Bogaert, Kris, additional, Van den Bosch, Filip, additional, Vatta, Matte, additional, Veenstra, Timothy D., additional, Veenstra, David L., additional, Vendrov, Aleksandr E., additional, Verfaillie, Catherine M., additional, Walley, Nicole M., additional, Wang, Ling, additional, Weale, Mike, additional, Weinblatt, Michael E., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Weissleder, Ralph, additional, Wells, Samuel A., additional, Wenner, Brett R., additional, Wiechers, Ilse R., additional, Wiesner, Georgia L., additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Wilson, James M., additional, Wivel, Nelson A., additional, Wohlgemuth, Jay, additional, Woodcock, Janet, additional, Woods, Christopher W., additional, Woon, Paula W., additional, Yagil, Chana, additional, Yagil, Yoram, additional, Yamamoto, Tadashi, additional, Yao, Gang, additional, Yee, Andrew J., additional, Yoo, Hyuntae, additional, You, Y. Nancy, additional, Yu, Li-Rong, additional, Zagury, Jean-François, additional, Zimmern, Ron, additional, and Züchner, Stephan, additional

Published
2009
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45. Responses of mental stress-induced myocardial ischemia to escitalopram treatment: Background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial

Author

Jiang, Wei, Velazquez, Eric J., Samad, Zainab, Kuchibhatla, Maragatha, Martsberger, Carolyn, Rogers, Joseph, Williams, Redford, Kuhn, Cynthia, Ortel, Thomas L., Becker, Richard C., Pristera, Nicole, Krishnan, Ranga, and OʼConnor, Christopher M.

Published
2012
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