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1. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice

Author

Swami, Srilatha, Krishnan, Aruna V, Williams, Jasmaine, Aggarwal, Abhishek, Albertelli, Megan A, Horst, Ronald L, Feldman, Brian J, and Feldman, David

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Complementary and Integrative Health, Prevention, Nutrition, Obesity, Breast Cancer, Aging, Estrogen, Cancer, Metabolic and endocrine, AMP-Activated Protein Kinases, Adiponectin, Adipose Tissue, Animals, Aromatase, Calcium, Cyclooxygenase 2, Diet, High-Fat, Dietary Supplements, Dinoprostone, Estradiol, Estrogens, Estrone, Female, Humans, Leptin, MCF-7 Cells, Mammary Glands, Animal, Mammary Neoplasms, Experimental, Mice, Mice, Inbred C57BL, Ovariectomy, RNA, Messenger, Tumor Burden, Vitamin D, breast cancer, vitamin D, obesity, adipokines, aromatase, Biological Sciences, Medical and Health Sciences, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Obesity is an established risk factor for postmenopausal breast cancer (BCa), insulin resistance, and vitamin D deficiency, and all contribute to increased synthesis of mammary estrogens, the drivers of estrogen receptor-positive (ER+) BCa growth. As both dietary vitamin D and calcitriol treatments inhibit breast estrogen synthesis and signaling, we hypothesized that vitamin D would be especially beneficial in mitigating the adverse effects of obesity on ER+BCa. To assess whether obesity exerted adverse effects on BCa growth and whether vitamin D compounds could reduce these unfavorable effects, we employed a diet-induced obesity (DIO) model in ovariectomized C57BL/6 mice. Breast tumor cells originally from syngeneic Mmtv-Wnt1 transgenic mice were then implanted into the mammary fat pads of lean and obese mice. DIO accelerated the initiation and progression of the mammary tumors. Treatments with either calcitriol or dietary vitamin D reduced the adverse effects of obesity causing a delay in tumor appearance and inhibiting continued tumor growth. Beneficial actions of treatments with vitamin D or calcitriol on BCa and surrounding adipose tissue included repressed Esr1, aromatase, and Cox2 expression; decreased tumor-derived estrogen and PGE2; reduced expression of leptin receptors; and increased adiponectin receptors. We demonstrate that vitamin D treatments decreased insulin resistance, reduced leptin, and increased adiponectin signaling and also regulated the LKB1/AMPK pathway contributing to an overall decrease in local estrogen synthesis in the obese mice. We conclude that calcitriol and dietary vitamin D, acting by multiple interrelated pathways, mitigate obesity-enhanced BCa growth in a postmenopausal setting.

Published
2016

2. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D

Author

Jeong, Youngtae, Swami, Srilatha, Krishnan, Aruna V, Williams, Jasmaine D, Martin, Shanique, Horst, Ronald L, Albertelli, Megan A, Feldman, Brian J, Feldman, David, and Diehn, Maximilian

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Nutrition, Breast Cancer, Animals, Body Weight, Calcitriol, Calcium, Cell Line, Tumor, Estrogens, Female, Mammary Neoplasms, Experimental, Mice, Neoplastic Stem Cells, Receptors, Calcitriol, Receptors, Estrogen, Tumor Burden, Vitamin D, Wnt Signaling Pathway, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

The anticancer actions of vitamin D and its hormonally active form, calcitriol, have been extensively documented in clinical and preclinical studies. However, the mechanisms underlying these actions have not been completely elucidated. Here, we examined the effect of dietary vitamin D and calcitriol on mouse breast tumor-initiating cells (TICs, also known as cancer stem cells). We focused on MMTV-Wnt1 mammary tumors, for which markers for isolating TICs have previously been validated. We confirmed that these tumors expressed functional vitamin D receptors and estrogen receptors (ER) and exhibited calcitriol-induced molecular responses including ER downregulation. Following orthotopic implantation of MMTV-Wnt1 mammary tumor cells into mice, calcitriol injections or a vitamin D-supplemented diet caused a striking delay in tumor appearance and growth, whereas a vitamin D-deficient diet accelerated tumor appearance and growth. Calcitriol inhibited TIC tumor spheroid formation in a dose-dependent manner in primary cultures and inhibited TIC self-renewal in secondary passages. A combination of calcitriol and ionizing radiation inhibited spheroid formation more than either treatment alone. Further, calcitriol significantly decreased TIC frequency as evaluated by in vivo limiting dilution analyses. Calcitriol inhibition of TIC spheroid formation could be overcome by the overexpression of β-catenin, suggesting that the inhibition of Wnt/β-catenin pathway is an important mechanism mediating the TIC inhibitory activity of calcitriol in this tumor model. Our findings indicate that vitamin D compounds target breast TICs reducing tumor-initiating activity. Our data also suggest that combining vitamin D compounds with standard therapies may enhance anticancer activity and improve therapeutic outcomes.

Published
2015

8. The Role of Vitamin D in Prostate Cancer

Author

Krishnan, Aruna V., Peehl, Donna M., Feldman, David, Schlag, P. M., editor, Senn, H.-J, editor, Kleihues, P., editor, Stiefel, F., editor, Groner, B., editor, Wallgren, A., editor, Reichrath, Jörg, editor, Tilgen, Wolfgang, editor, and Friedrich, Michael, editor

Published
2003
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12. Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer

Author

Swami, Srilatha, Krishnan, Aruna V., Moreno, Jacqueline, Bhattacharyya, Rumi B., Peehl, Donna M., and Feldman, David

Subjects
Prostate cancer -- Diet therapy, Prostate cancer -- Care and treatment, Prostate cancer -- Research, Calcitriol -- Research, Calcitriol -- Health aspects, Isoflavones -- Research, Isoflavones -- Health aspects, Prostaglandins -- Research, Food/cooking/nutrition
Abstract

We present an overview of the prostaglandin (PG) pathway as a novel target for the treatment of prostate cancer (PCa) using a combination of calcitriol and genistein, both of which have known antiproliferative properties. Calcitriol inhibits the PG pathway in PCa cells in 3 separate ways: by decreasing cyclooxygenase-2 (COX-2) expression, stimulating 15-hydroxyprostaglandin dehydrogenase (15-PGDH) expression, and decreasing EP ([PGE.sub.2]) and FP ([PGF.sub.2[alpha]]) receptors. These actions of calcitriol result in reduced levels of biologically active [PGE.sub.2], leading ultimately to growth inhibition of the PCa cells. We also demonstrate the advantages of using calcitriol in combination with genistein for the treatment of PCa. Genistein, a major component of soy, is a potent inhibitor of the activity of CYP24, the enzyme that initiates the degradation of calcitriol. This leads to increased half-life of bioactive calcitriol, thereby enhancing all of calcitriol's actions including those on the PG pathway. In addition to inhibiting CYP24 enzyme activity, genistein has its own independent actions on the PG pathway in PCa cells. Like calcitriol it inhibits COX-2 expression and activity, leading to decreased synthesis of [PGE.sub.2]. It also inhibits the EP and FP receptors, thereby reducing the biological function of [PGE.sub.2]. Thus, the combination of calcitriol and genistein acts additively to inhibit the PG pathway. Both calcitriol and genistein are relatively safe and have little toxicity associated with their intake. We postulate that the combination of calcitriol and genistein is an attractive therapeutic option for the treatment of PCa. J. Nutr. 137: 205S-210S, 2007.

Published
2007

13. Contributors

Author

Adler, Robert A., primary, Anderson, Dennis E., additional, Arabi, Asma, additional, Arnett, Timothy R., additional, Bachrach, Laura K., additional, Ballane, Ghada, additional, Baran, Daniel, additional, Barnes, George L., additional, Baron, Roland, additional, Bauer, Douglas C., additional, Bauman, William A., additional, Berndt, Theresa J., additional, Berry, Sarah D., additional, Bilezikian, John P., additional, Bolam, Kate A., additional, Bonewald, Lynda F., additional, Bonnick, Sydney Lou, additional, Boonen†, Steven, additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Bouxsein, Mary L., additional, Brown, Todd T., additional, Broy, Susan B., additional, Bruno, Alexander G., additional, Bukata, Susan V., additional, Burr, David B., additional, Canalis, Ernesto, additional, Cardozo, Christopher P., additional, Castillo, Alesha B., additional, Cauley, Jane A., additional, Center, Jacqueline R., additional, Chen, Julia C., additional, Civitelli, Roberto, additional, Cohen, Adi, additional, Coleman, Robert, additional, Compston, Juliet, additional, Cosman, Felicia, additional, Costa, Aline, additional, Cusano, Natalie E., additional, Daly, Robin M., additional, Danielson, Michelle E., additional, Dansey, Roger, additional, de Paula, Francisco J.A., additional, Delbaere, Kim, additional, Dempster, David W., additional, Diab, Dima L., additional, Dick-de-Paula, Ingrid, additional, DiMeglio, Linda A., additional, Einhorn, Thomas A., additional, Elder, Grahame J., additional, Ensrud, Kristine E., additional, Ettinger, Bruce, additional, Feldman, David, additional, Ferraro, Francesca, additional, Fitzpatrick, Lorraine A., additional, El-Hajj Fuleihan, Ghada, additional, Galvão, Daniel A., additional, Gass, Margery L.S., additional, Genant, Harry K., additional, Gold, Deborah T., additional, Goldring, Steven R., additional, Gori, Francesca, additional, Greendale, Gail A., additional, Griffith, James F., additional, Heaney, Robert P., additional, Heath, Hunter, additional, Hernandez, Christopher J., additional, Hoggatt, Jonathan, additional, Hoy, Christa L., additional, Hussein, Amira I., additional, Iwaniec, Urszula T., additional, Jacobs, Christopher R., additional, Jeffcoat, Marjorie K., additional, Johansson, Helena, additional, Judex, Stefan, additional, Kanis, John A., additional, Karim, Lamya, additional, Kawai, Masanobu, additional, Kemmis, Karen L., additional, Khan, Sobia, additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Kostenuik, Paul, additional, Krishnan, Aruna V., additional, Kronenberg, Henry, additional, Kumar, Rajiv, additional, Leonard, Mary B., additional, Lewiecki, E. Michael, additional, Lian, Jane B., additional, Lindsay, Robert, additional, Lipton, Allan, additional, Lord, Stephen R., additional, Lorenzo, Joseph, additional, Luckey, Marjorie, additional, Macdonald, Heather M., additional, Marcus, Robert, additional, Martin, T. John, additional, McCloskey, Eugene V., additional, McClung, Michael R., additional, McDonnell, Donald P., additional, McKay, Heather A., additional, Miller, Paul, additional, Morgan, Elise F., additional, Mughal, M. Zulf, additional, Al Mukaddam, Mona, additional, Nelson, Erik R., additional, Nelson, Dorothy A., additional, Nieves, Jeri W., additional, Nissenson, Robert A., additional, Nordin, B.E. Christopher, additional, Odén, Anders, additional, Orwoll, Eric S., additional, Ott, Susan M., additional, Pacifici, Roberto, additional, Pack, Alison M., additional, Parfitt, A. Michael, additional, Park, Dongsu, additional, Premaor, Melissa, additional, Provot, Sylvain, additional, Qin, Yi-Xian, additional, Randolph, John F., additional, Reid, Ian R., additional, Rivadeneira, Fernando, additional, Rizzoli, René, additional, Robey, Pamela Gehron, additional, Roodman, G. David, additional, Rosen, Clifford J., additional, Rubin, Clinton T., additional, Rubin, Janet, additional, Saag, Kenneth G., additional, Saylor, Philip J., additional, Scadden, David T., additional, Schipani, Ernestina, additional, Shane, Elizabeth, additional, Shapiro, Jay R., additional, Sherrington, Catherine, additional, Silbermann, Rebecca, additional, Silva, Barbara C., additional, Silverberg, Shonni J., additional, Smith, Matthew R., additional, Snyder, Peter J., additional, Sowers, MaryFran R., additional, Stein, Gary S., additional, Stein, Emily, additional, Stern, Paula H., additional, Stuenkel, Cynthia A., additional, Suominen, Harri, additional, Swami, Srilatha, additional, Szulc, Pawel, additional, Taaffe, Dennis R., additional, Taylor, Brent C., additional, Tebben, Peter J., additional, Turner, Russell T., additional, Uitterlinden, André G., additional, van de Peppel, Jeroen, additional, Van der Eerden, Bram C.J., additional, van der Meulen, Marjolein C.H., additional, van Leeuwen, Johannes P.T.M., additional, Vanderschueren, Dirk, additional, Wagman, Rachel B., additional, Ward, Leanne, additional, Wardell, Suzanne E., additional, Watts, Nelson B., additional, Weinstein, Robert S., additional, Wiren, Kristine M., additional, Wu, Joy Y., additional, Yin, Michael T., additional, Zhou, Hua, additional, and Zillikens, M. Carola, additional

Published
2013
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14. Vitamin D

Author

Feldman, David, primary, Krishnan, Aruna V., additional, and Swami, Srilatha, additional

Published
2013
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15. Contributors

Author

Abrams, Steven A., primary, Adams, John S., additional, Adams, Judith E., additional, Adorini, Luciano, additional, Anderson, Paul H., additional, Arab, Lenore, additional, Atkins, Gerald J., additional, Berdal, Ariane, additional, Bhan, Ishir, additional, Bikle, Daniel, additional, Bilezikian, John P., additional, Bischoff-Ferrari, Heike, additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Boyan, Barbara D., additional, Brown, Alex J., additional, Brown, Edward M., additional, Bruce, Danny, additional, Burghardt, Andrew J., additional, Burne, Thomas, additional, Calvo, Mona S., additional, Camargo, Carlos A., additional, Cantorna, Margherita, additional, Carlberg, Carsten, additional, Carpenter, Thomas O., additional, Carson, Matthew W., additional, Ceglia, Lisa, additional, Chen, Hong, additional, Chen, Songcang, additional, Christakos, Sylvia, additional, Coe, Fredric L., additional, Compston, Juliet, additional, Cross, Heide S., additional, Cusano, Natalie E., additional, Dawson-Hughes, Bess, additional, De Clercq, Pierre, additional, DeLuca, Hector, additional, Danilenko, Michael, additional, David, Valentin, additional, Deluca, Hector F., additional, Demay, Marie B., additional, de Paula, Francisco J.A., additional, Descroix, Vianney, additional, Dhawan, Puneet, additional, Dixon, Katie M., additional, Dobnig, Harald, additional, Dodge, Jeffrey A., additional, Donnelly, Eve, additional, Doroudi, Maryam, additional, Dowd, Diane R., additional, Drezner, Marc K., additional, Dusso, Adriana S., additional, Ebeling, Peter R., additional, Edouard, Thomas, additional, Eelen, Guy, additional, Eisman, John A., additional, Epps, Tina, additional, Epstein, Ervin H., additional, Epstein, Sol, additional, Eyles, Darryl, additional, Farach-Carson, Mary C., additional, Favus, Murray J., additional, Feldman, David, additional, Findlay, David M., additional, Fleet, James C., additional, Franceschi, Renny T., additional, Fujiki, Ryoji, additional, Gardner, David G., additional, Ginde, Adit A., additional, Giovannucci, Edward, additional, Glenn, Denis J., additional, Glorieux, Francis H., additional, Gocek, Elzbieta, additional, Goltzman, David, additional, González-Sancho, José Manuel, additional, Gordon-Thomson, Clare, additional, Gysemans, Conny, additional, Hansen, Karen E., additional, Haussler, Carol A., additional, Haussler, Mark R., additional, Hayes, Colleen E., additional, Heaney, Robert P., additional, Helvig, Christian, additional, Hendy, Geoffrey N., additional, Hewison, Martin, additional, Hirsch, Arnold Lippert, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Holt, Elizabeth, additional, Hsieh, Jui-Cheng, additional, Insogna, Karl L., additional, Johnson, Candace, additional, Jones, Glenville, additional, Jurutka, Peter W., additional, Kalkwarf, Heidi J., additional, Kato, Shigeaki, additional, Kliewer, Steven A., additional, Koeffler, H. Phillip, additional, Korf, Hannelie, additional, Kouzmenko, Alexander, additional, Kovacs, Christopher S., additional, Kream, Barbara E., additional, Kremer, Richard, additional, Krishnan, Aruna V., additional, Krug, Roland, additional, Kubodera, Noboru, additional, Kumar, Rajiv, additional, Laing, Emma M., additional, Lane, Joseph M., additional, Larriba, María Jesús, additional, Lee, Seong Min, additional, Lewis, Richard D., additional, Li, Yan, additional, Li, Yan Chun, additional, Lian, Jane B., additional, Lichtler, Alexander C., additional, Lips, Paul, additional, Liu, Philip T., additional, Lisse, Thomas S., additional, Ma, Yanfei L., additional, MacDonald, Paul N., additional, Mady, Leila, additional, Maggi, Mario, additional, Majumdar, Sharmila, additional, Makishima, Makoto, additional, Malloy, Peter J., additional, Mangelsdorf, David J., additional, Mansbach, Jonathan M., additional, Manson, JoAnn E., additional, Mason, Rebecca S., additional, Mathieu, Chantal, additional, Mayne, Christopher G., additional, McAlindon, Timothy M., additional, McGrath, John, additional, Meyer, Mark B., additional, Mizwicki, Mathew T., additional, Molla, Muriel, additional, Montecino, Martin, additional, Moras, Dino, additional, Morelli, Annamaria, additional, Morris, Howard A., additional, Muñoz, Alberto, additional, Nanes, Mark S., additional, Nashold, Faye E., additional, Naveh-Many, Tally, additional, Ni, Wei, additional, Nelson, Corwin D., additional, Norman, Anthony W., additional, Ohtake, Fumiaki, additional, Okamoto, Ryoko, additional, Okereke, Olivia I., additional, Pal, Lubna, additional, Petkovich, Martin, additional, Pettifor, John M., additional, Pike, J. Wesley, additional, Pittas, Anastassios G., additional, Plum, Lori A., additional, Prosser, David E., additional, Quarles, L. Darryl, additional, Rebolledo, Brian J., additional, Reichrath, Jörg, additional, Rochel, Natacha, additional, Rosen, Clifford J., additional, Ross, F. Patrick, additional, Sambrook, Philip, additional, Schmidt, Daniel R., additional, Schoch, Ryan D., additional, Schwartz, Gary G., additional, Schwartz, Zvi, additional, Sequeira, Vanessa, additional, Shane, Elizabeth, additional, Shea, M. Kyla, additional, Silver, Justin, additional, Simpson, Robert U., additional, Skingle, Linda, additional, Slatopolsky, Eduardo, additional, Sourij, Harald, additional, Spanier, Justin A., additional, Specker, Bonny L., additional, St-Arnaud, René, additional, Stayrook, Keith R., additional, Stein, Emily M., additional, Stein, Gary S., additional, Stein, Janet L., additional, Studzinski, George P., additional, Takahashi, Fumiaki, additional, Tang, Jean Y., additional, Taylor, Hugh S., additional, Tebben, Peter, additional, Thadhani, Ravi, additional, Thiex, Natalie W., additional, Thompson, William R., additional, Thys-Jacobs, Susan, additional, Tiosano, Dov, additional, Towler, Dwight A., additional, Trump, Donald, additional, Uitterlinden, André G., additional, Unnanuntana, Aasis, additional, Vandewalle, Maurits, additional, van Driel, Marjolein, additional, van Leeuwen, Johannes P.T.M., additional, van Wijnen, Andre J., additional, van Schoor, Natasja, additional, Verlinden, Lieve, additional, Verstuyf, Annemieke, additional, Vieth, Reinhold, additional, Weaver, Connie M., additional, Weinstein, Barrie M., additional, Welsh, JoEllen, additional, White, John H., additional, Whitfield, G. Kerr, additional, Whiting, Susan J., additional, Whyte, Michael P., additional, Wysolmerski, John J., additional, Yamada, Sachiko, additional, and Yip, Ian, additional

Published
2011
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17. Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer

Author

Peehl, Donna M., Krishnan, Aruna V., and Feldman, David

Subjects
Vitamin D -- Physiological aspects, Alfacalcidol -- Physiological aspects, Calcifediol -- Physiological aspects, Prostate cancer -- Prevention, Cancer cells -- Growth, Company growth, Food/cooking/nutrition
Abstract

Vitamin D is emerging as an important dietary factor that affects the incidence and progression of many malignancies including prostate cancer. The active form of vitamin D, 1,25-dihydroxycholecalciferol [1,25[(OH).sub.2][D.sub.3]], inhibits the growth and stimulates the differentiation of prostate cancer cells. We have studied primary cultures of normal and cancer-derived prostatic epithelial cells as well as established human prostate cancer cell lines to elucidate the molecular pathways of 1,25[(OH).sub.2][D.sub.3] actions. These pathways are varied and appear to be cell specific. In LNCaP cells, 1,25[(OH).sub.2][D.sub.3] mainly causes growth arrest through the induction of insulin-like growth factor binding protein-3 and also stimulates apoptosis to a much smaller extent. We have used cDNA-microarray analyses to identify additional genes that are regulated by 1,25[(OH).sub.2][D.sub.3] and to raise novel therapeutic targets for use in the chemoprevention or treatment of prostate cancer. Less calcemic analogs of 1,25[(OH).sub.2][D.sub.3] that have more antiproliferative activity are being developed that will be more useful clinically. In target cells, 1,25[(OH).sub.2][D.sub.3] induces 24-hydroxylase, the enzyme that catalyzes its self inactivation. Cotreatment with 24-hydroxylase inhibitors enhances the antiproliferative activity of 1,25[(OH).sub.2][D.sub.3]. The combination of other anticancer agents such as retinoids with vitamin D offers another promising therapeutic approach. A small clinical trial has shown that 1,25[(OH).sub.2][D.sub.3] can slow the rate of prostate-specific antigen increase in prostate cancer patients, which demonstrates proof of the concept that vitamin D or its analogs are clinically effective. Our research is directed at understanding the mechanisms of vitamin D action in prostate cells with the goal of developing chemoprevention and treatment strategies to improve prostate cancer therapy. KEY WORDS: * 1,25-dihydroxycholecalciferol * vitamin D analogs * vitamin D receptor * 24-hydroxylase * target genes

Published
2003

20. Contributors

Author

Balint, Eva, primary, Barnes, George L., additional, Beamer, Wesley G., additional, Berndt, Theresa J., additional, Blair, Harry C., additional, Bodine, Peter V.N., additional, Bonewald, Lynda F., additional, Boskey, Adele L., additional, Bouxsein, Mary L., additional, Canalis, Ernesto, additional, Cheskis, Boris, additional, Einhorn, Thomas A., additional, Elefteriou, Florent, additional, Feldman, David, additional, Gutierrez, Gloria, additional, Johnson, Mark L., additional, Komm, Barry S., additional, Krishnan, Aruna V., additional, Kronenberg, Henry, additional, Kumar, Rajiv, additional, Lacey, David L., additional, Lian, Jane B., additional, Malloy, Peter J., additional, Marcus, Robert, additional, Martin, T. John, additional, Morgan, Elise F., additional, Mundy, Gregory R., additional, Nissenson, Robert A., additional, Oyajobi, Babatunde, additional, Padalecki, Susan, additional, Parfitt, A.M., additional, Provot, Sylvain, additional, Recker, Robert R., additional, Robey, Pamela Gehron, additional, Rodan, Gideon A., additional, Rosen, Clifford J., additional, Schipani, Ernestina, additional, Simonet, Scott, additional, Stein, Gary S., additional, Sterling, Julie, additional, Tebben, Peter J., additional, Wiren, Kristine M., additional, Wu, Joy, additional, Zaidi, Mone, additional, Zhao, Ming, additional, and Zhu, Wei, additional

Published
2010
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26. Contributors

Author

Adler, Robert A., primary, Atmaca, Aysegul, additional, Bachrach, Laura K., additional, Balint, Eva, additional, Baran, Daniel, additional, Barnes, George L., additional, Barrett-Connor, Elizabeth, additional, Beamer, Wesley G., additional, Beaupré, Gary S., additional, Berndt, Theresa J., additional, Berry, Sarah D., additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Blair, Harry C., additional, Bodine, Peter V.N., additional, Bonewald, Lynda F., additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Bouxsein, Mary L., additional, Brown, Sue A., additional, Burnham, John M., additional, Burshell, Alan L., additional, Canalis, Ernesto, additional, Carter, Dennis R., additional, Cauley, Jane A., additional, Cheskis, Boris, additional, Civitelli, Roberto, additional, Cosman, Felicia, additional, Cummings, Steven R., additional, Curtis, Jeffrey, additional, Delmas, Pierre D., additional, Dempster, David W., additional, Dresner-Pollak, Rivka, additional, Einhorn, Thomas A., additional, Elefteriou, Florent, additional, Ensrud, Kristine E., additional, Epstein, Sol, additional, Faulkner, Kenneth G., additional, Feldman, David, additional, Fitzpatrick, Lorraine A., additional, Fritton, J. Christopher, additional, Genant, Harry K., additional, Gold, Deborah T., additional, Goldring, Steven R., additional, Greendale, Gail A., additional, Guise, Theresa A., additional, Gutierrez, Gloria, additional, Halloran, Bernard, additional, Heaney, Robert P., additional, Heggeness, Michael H., additional, Heras-Herzig, Ailleen, additional, Hillier, Teresa A., additional, Hochberg, Marc, additional, Iwaniec, Urzula T., additional, Jeffcoat, Marjorie K., additional, Jergas, Michael, additional, Johnson, Mark L., additional, Judex, Stefan, additional, Kannus, Pekka, additional, Karsenty, Gerard, additional, Karvonen-Gutierrez, Carrie A., additional, Kennel, Kurt A., additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Kleerekoper, Michael, additional, Klein, Robert F., additional, Komm, Barry S., additional, Kozlow, Wende M., additional, Krishnan, Aruna V., additional, Kronenberg, Henry, additional, Kumar, Rajiv, additional, Lacey, David L., additional, Leonard, Mary B., additional, Lian, Jane B., additional, Lindsay, Robert, additional, Lloyd, Tom, additional, Lowe, Hyesoo, additional, Malloy, Peter J., additional, Maloney, W.J., additional, Marcus, Robert, additional, Martin, T. John, additional, Mathis, Kenneth, additional, McClung, Michael R., additional, McGowan, Joan A., additional, McKay, Heather A., additional, III, L. Joseph Melton, additional, Miller, Paul D., additional, Mitlak, Bruce H., additional, Montori, Victor M., additional, Morgan, Elise F., additional, Muchmore, Douglas B., additional, Mundy, Gregory R., additional, Nauman, Eric A., additional, Nelson, Dorothy A., additional, Nguyen, Nguyen Dinh, additional, Nguyen, Tuan V., additional, Nieves, Jeri W., additional, Nissenson, Robert A., additional, Niu, Tim, additional, Nordin, B. E. Christopher, additional, Norris, Shane A., additional, Nugaram, Rekha, additional, Orwoll, Eric S., additional, Oyajobi, Babatunde, additional, Pacifici, Roberto, additional, Padalecki, Susan, additional, Parfitt, A.M., additional, Petit, Moira A., additional, Pettifor, John M., additional, Pols, Huibert A.P., additional, Prince, Richard, additional, Provot, Sylvain, additional, Qin, Yi-Xian, additional, Raisz, Lawrence G., additional, Recker, Robert R., additional, Reid, Ian R., additional, Reitman, Charles, additional, Riggs, B. Lawrence, additional, Rivadeneira, Fernando, additional, Rizzoli, René, additional, Robey, Pamela Gehron, additional, (deceased), Gideon A. Rodan, additional, Rosen, Clifford J., additional, Rosenblatt, Michael, additional, Rubin, Clinton, additional, Rubin, Janet, additional, Saag, Kenneth G., additional, Schaffler, Mitchell B., additional, Schipani, Ernestina, additional, Schurman, D.J., additional, Seeman, Ego, additional, Shane, Elizabeth, additional, Shapiro, Jay, additional, Sievanen, Harri, additional, Silverberg, Shonni J., additional, Simonet, Scott, additional, Siris, Ethel S., additional, Smith, R.L., additional, Snyder, Peter J., additional, Solimeo, Samantha, additional, Sowers, MaryFran, additional, Stefanick, Marcia L., additional, Stein, Gary S., additional, Sterling, Julie, additional, Stoch, S. Aubrey, additional, Stone, Katie L., additional, Swiglo, Brian A., additional, Szulc, Pawel, additional, Tebben, Peter J., additional, Tosteson, Anna N.A., additional, Turner, Russell T., additional, Uitterlinden, André G., additional, Uusi-Rasi, Kirsti, additional, van der Meulen, Marjolein C.H., additional, van Leeuwen, Hans P.T.M., additional, van Meurs, Joyce B.J., additional, Vanness, David J., additional, Wagman, Rachel B., additional, Ward, Leanne, additional, Weinstein, Robert S., additional, Wiren, Kristine M., additional, Wu, Joy, additional, Zaidi, Mone, additional, Zhao, Ming, additional, Zhou, Hua, additional, and Zhu, Wei, additional

Published
2008
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31. List of Contributors

Author

Abrams, Steven A., primary, Adams, John S., additional, Adams, Judith E., additional, Adorini, Luciano, additional, Anderson, Paul H., additional, Atkins, Gerald J., additional, Aubin, Jane E., additional, Bailleul-Forestier, Isabelle, additional, Barsony, Julia, additional, Barthel, Thomas K., additional, Bell, Norman H., additional, Berdal, Ariane, additional, Bergh, Joel J., additional, Berry, Jacqueline L., additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binderup, Ernst, additional, Binderup, Lise, additional, Bishop, Nicholas J., additional, Bogaerts, Ilse, additional, Boland, Ricardo L., additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Boyan, Barbara D., additional, Brachet, Philippe, additional, Brown, Alex J., additional, Brown, Edward M., additional, Carlberg, Carsten, additional, Carmeliet, Geert, additional, Carpenter, Thomas O., additional, Chapuy, Marie-Claire, additional, Chan, Fredriech K.W., additional, Chen, Tai C., additional, Christakos, Sylvia, additional, Clagett-Dame, Margaret, additional, Clemens, Thomas L., additional, Choi, Je-Yong, additional, Coe, Fredric L., additional, Colston, Kay, additional, Compston, Juliet E., additional, Cooke, Nancy E., additional, Crescioli, Clara, additional, Cross, Heide S., additional, Danilenko, Michael, additional, Davideau, Jean-Luc, additional, Davies, Michael, additional, DeLuca, Hector F., additional, Demay, Marie B., additional, Dhawan, Puneet, additional, Dominguez, Carlos Encinas, additional, Dowd, Diane R., additional, Drezner, Marc K., additional, Dunlop, Thomas W., additional, Dusso, Adriana S., additional, Eastell, Richard, additional, Econs, Michael J., additional, Eisman, John, additional, Epstein, Sol, additional, Eriksen, Erik Fink, additional, Esteban, Luis M., additional, Faibish, Dan, additional, Fang, Yue, additional, Farach-Carson, Mary C., additional, Favus, Murray J., additional, Feldman, David, additional, Findlay, David, additional, Frank, Christian, additional, Freedman, Leonard P., additional, Fujiki, Ryuji, additional, Fukagawa, Masafumi, additional, Gagel, Robert F., additional, Garcion, Emmanuel, additional, Gardiner, Edith M., additional, Gascon-Barré, Marielle, additional, Giovannucci, Edward, additional, Glerup, Henning, additional, Glorieux, Francis H., additional, Godtfredsen, Wagn O., additional, Goltzman, David, additional, Gutierrez, Soraya, additional, Gysemans, Conny, additional, Halloran, Bernard P., additional, Haussler, Carol A., additional, Haussler, Mark R., additional, Heaney, Robert P., additional, Heersche, Johan, additional, Henry, Helen L., additional, Hershberger, Pamela A., additional, Hewison, Martin, additional, Heyman, Richard A., additional, Higashio, Kanji, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Horst, Ronald L., additional, Hsieh, Jui-Cheng, additional, Insogna, Karl L., additional, Jacobs, Elizabeth T., additional, Javed, Amjad, additional, Jones, Glenville, additional, Johnson, Candace S., additional, Jurutka, Peter W., additional, Kahraman, Mehmet, additional, Zaidi, S. Kaleem, additional, Kalkwarf, Heidi J., additional, Kato, Shigeaki, additional, Kissmeyer, Anne-Marie, additional, Kitagawa, Hirochika, additional, Koberle, Lilia M.C., additional, Koeffler, H. Phillip, additional, Koren, Ruth, additional, Kream, Barbara E., additional, Kremer, Richard, additional, Krishnan, Aruna V., additional, Kubodera, Noboru, additional, Kumar, Rajiv, additional, Kurokawa, Kiyoshi, additional, Laing, Christopher J., additional, Lemire, Jacques, additional, Lézot, Frédéric, additional, Li, Yan Chun, additional, Lian, Jane B., additional, Lichtler, Alexander C., additional, Lips, Paul, additional, Liu, Yan, additional, MacDonald, Paul, additional, Maehr, Hubert, additional, Maggi, Mario, additional, Malloy, Peter J., additional, Mangelsdorf, David J., additional, Mathieu, Chantal, additional, May, Brian, additional, Mee, Andrew P., additional, Meunier, Pierre J., additional, Michigami, Toshimi, additional, Montecino, Martin, additional, Moras, Dino, additional, Morosetti, Roberta, additional, Morris, Howard A., additional, Motola, Daniel L., additional, Muindi, Josephia, additional, Nakajima, Shigeo, additional, Naveh-Many, Tally, additional, Naveilhan, Philippe, additional, Neveu, Isabelle, additional, Norman, Anthony W., additional, Nykjaer, Anders, additional, O'Kelly, James, additional, Omdahl, John L., additional, Ordentlich, Peter, additional, Ozono, Keiichi, additional, Parfitt, A. Michael, additional, Peehl, Donna M., additional, Peleg, Sara, additional, Peng, Xiaorong, additional, Pettifor, John M., additional, Pike, J. Wesley, additional, Platz, Elizabeth A., additional, Plum, Lori A., additional, Pockwinse, Shirwin, additional, Pols, Huibert A.P., additional, Portale, Anthony A., additional, Posner, Gary H., additional, Rahmaniyan, Mehrdad, additional, Ravid, Amiram, additional, Reddy, G. Satyanarayana, additional, Reichrath, Jörg, additional, Reinhardt, Timothy A., additional, Reszka, Alfred A., additional, Riggs, B. Lawrence, additional, Rochel, Natacha, additional, Rubin, Mishaela R., additional, Russo, Andrew F., additional, Sambrook, Philip, additional, Schneider, Adina E., additional, Schwartz, Gary G., additional, Schwartz, Zvi, additional, Shen, Jiali, additional, Shevde, Nirupama K., additional, Sicinski, Rafal R., additional, Silver, Justin, additional, Slatopolsky, Eduardo A., additional, Specker, Bonny L., additional, St-Arnaud, René, additional, Stein, Gary S., additional, Stein, Janet L., additional, Stern, Paula H., additional, Studzinski, George P., additional, Suda, Tatsuo, additional, Sutton, Amelia L.M., additional, Tebben, Peter, additional, Tenenhouse, Harriet S., additional, Thatcher, Michelle L., additional, Thys-Jacobs, Susan, additional, Towler, Dwight A., additional, Trump, Donald L., additional, Uitterlinden, André G., additional, Uskoković, Milan R., additional, Väisänen, Sami, additional, Van Baelen, Hugo, additional, Van Cromphaut, Sophie, additional, van Leeuwen, Johannes P.T.M., additional, van Meurs, Joyce B.J., additional, van Wijnen, Andre J., additional, Verboven, Christel, additional, Vieth, Reinhold, additional, Wasserman, Robert H., additional, Welsh, JoEllen, additional, Whitfield, G. Kerr, additional, Whyte, Michael P., additional, Willnow, Thomas, additional, Wion, Didier, additional, Yasuda, Hisataka, additional, Young, Daniel, additional, and Zhang, Chi, additional

Published
2005
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