Search

Your search keyword '"Krishnamurthy, Narasimha Rao"' showing total 8 results
Start Over Author "Krishnamurthy, Narasimha Rao"
8 results on '"Krishnamurthy, Narasimha Rao"'

1. Abstract 1266: Discovery and preclinical evaluation of a novel covalent inhibitor of FABP5 for cancer therapy

Author

Chikkanna, Dinesh, primary, Satyam, Leena Khare, additional, Pnaigrahi, Sunil Kumar, additional, Khairnar, Vinayak, additional, Pothuganti, Manoj, additional, Kaza, Lakshmi Narayan, additional, Kalidindi, Narasimha Raju, additional, Nataraj, Vijaya Shankar, additional, Gatta, Aditya Kiran, additional, Krishnamurthy, Narasimha Rao, additional, Patil, Sandeep, additional, Samiulla, DS, additional, Aithal, Kiran, additional, Ahuja, Vijay Kamal, additional, Tiwari, Nirbhay Kumar, additional, Charamannna, KB, additional, Pise, Pravin, additional, Anthony, Thomas, additional, Nellore, Kavitha, additional, Giri, Sanjeev, additional, Chelur, Shekar, additional, Samajdar, Susanta, additional, and Ramachandra, Murali, additional

Published
2021
Full Text
View/download PDF

2. Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies

Author

Gummadi, Venkateshwar Rao, primary, Boruah, Anima, additional, Ainan, Bharathi Raja, additional, Vare, Brahma Reddy, additional, Manda, Srinivas, additional, Gondle, Hari Prakash, additional, Kumar, Shiva Nagendra, additional, Mukherjee, Subhendu, additional, Gore, Suraj T., additional, Krishnamurthy, Narasimha Rao, additional, Marappan, Sivapriya, additional, Nayak, Shilpa S., additional, Nellore, Kavitha, additional, Balasubramanian, Wesley Roy, additional, Bhumireddy, Archana, additional, Giri, Sanjeev, additional, Gopinath, Sreevalsam, additional, Samiulla, Dodheri S., additional, Daginakatte, Girish, additional, Basavaraju, Aravind, additional, Chelur, Shekar, additional, Eswarappa, Rajesh, additional, Belliappa, Charamanna, additional, Subramanya, Hosahalli S., additional, Booher, Robert N., additional, Ramachandra, Murali, additional, and Samajdar, Susanta, additional

Published
2020
Full Text
View/download PDF

4. Correction to “Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)”

Author

Lagu, Bharat, primary, Kluge, Arthur F., additional, Tozzo, Effie, additional, Fredenburg, Ross, additional, Bell, Eric L., additional, Goddeeris, Matthew M., additional, Dwyer, Peter, additional, Basinski, Andrew, additional, Senaiar, Ramesh S., additional, Jaleel, Mahaboobi, additional, Tiwari, Nirbhay Kumar, additional, Panigrahi, Sunil K., additional, Krishnamurthy, Narasimha Rao, additional, Takahashi, Taisuke, additional, and Patane, Michael A., additional

Published
2019
Full Text
View/download PDF

5. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)

Author

Lagu, Bharat, primary, Kluge, Arthur F., additional, Tozzo, Effie, additional, Fredenburg, Ross, additional, Bell, Eric L., additional, Goddeeris, Matthew M., additional, Dwyer, Peter, additional, Basinski, Andrew, additional, Senaiar, Ramesh S., additional, Jaleel, Mahaboobi, additional, Tiwari, Nirbhay Kumar, additional, Panigrahi, Sunil K., additional, Krishnamurthy, Narasimha Rao, additional, Takahashi, Taisuke, additional, and Patane, Michael A., additional

Published
2018
Full Text
View/download PDF

6. Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode

Author

Gummadi, Venkateshwar Rao, Rajagopalan, Sujatha, Looi, Chung-Yeng, Paydar, Mohammadjavad, Renukappa, Girish Aggunda, Ainan, Bharathi Raja, Krishnamurthy, Narasimha Rao, Panigrahi, Sunil Kumar, Mahasweta, Kumari, Raghuramachandran, Sangeetha, Rajappa, Manoj, Ramanathan, Anuradha, Lakshminarasimhan, Anirudha, Ramachandra, Murali, Wong, Pooi-Fong, Mustafa, Mohammad Rais, Nanduri, Srinivas, and Hosahalli, Subramanya

Published
2013
Full Text
View/download PDF

7. Structural studies on C-2 substitution in a new set of synthetic aminodideoxy sugars: the steric bulk at C-2 influences the puckering of the pyranose ring

Author

Krishnamurthy Narasimha Rao, Tanmaya Pathak, Chiravakkattu G. Suresh, Bindu Ravindran, J. Shashidharaprasad, and Neratur Krishnappagowda Lokanath

Subjects
Steric effects, Models, Molecular, Anomer, Magnetic Resonance Spectroscopy, Stereochemistry, Chemistry, Organic Chemistry, Substitution (logic), Stereoisomerism, Amino Sugars, General Medicine, Nuclear magnetic resonance spectroscopy, Crystallography, X-Ray, Biochemistry, Analytical Chemistry, Structure-Activity Relationship, Pyranose, Deoxy Sugars, Carbohydrate Conformation, Structure–activity relationship, Carbohydrate conformation, Pyrans
Abstract

Synthesis and single-crystal X-ray structural analyses of selected aminodideoxy sugars with different group substitutions at the C-2 position were carried out. Product formation and X-ray crystallographic determination of the products from C-2 substitution in both alpha and beta anomers were studied. The observed variation in pyranose ring conformations in product compounds is explained in terms of C-2 substitution.

Published
2002

8. X-ray structure of PTP1B in complex with a new PTP1B inhibitor.

Author

Reddy MV, Ghadiyaram C, Panigrahi SK, Krishnamurthy NR, Hosahalli S, Chandrasekharappa AP, Manna D, Badiger SE, Dubey PK, and Mangamoori LN

Subjects
Animals, Cloning, Molecular, Crystallography, X-Ray, Diabetes Mellitus, Type 2 therapy, Mice, Mice, Knockout, Obesity therapy, Protein Tyrosine Phosphatase, Non-Receptor Type 1 genetics, Binding Sites drug effects, Catalytic Domain drug effects, Protein Tyrosine Phosphatase, Non-Receptor Type 1 antagonists & inhibitors, Protein Tyrosine Phosphatase, Non-Receptor Type 1 ultrastructure
Abstract

Protein tyrosine phosphatase 1B (PTP1B) is a prototype non receptor cytoplasmic PTPase enzyme that has been implicated in regulation of insulin and leptin signaling pathways. Studies on PTP1B knockout mice and PTP1B antisense treated mice suggested that inhibition of PTP1B would be an effective strategy for the treatment of type II diabetes and obesity. Here we report the X-ray structure of PTP1B in complex with compound IN1834-146C (PDB ID 4I8N). The crystals belong to P3121 space group with cell dimensions (a = b = 87.89 Å, c = 103.68 Å) diffracted to 2.5 Å. The crystal structure contained one molecule of protein in the asymmetric unit and was solved by molecular replacement method. The compound engages both catalytic site and allosteric sites of PTP1B protein. We described the molecular interaction of the compound with the active site residues of PTP1B in this crystal structure report.

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results