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1. Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR-and EGFRvIII-overexpressing tumor cells.

Author

Mamot, C., Drummond, D. C., Greiser, U., Hong, K., Kirpotin, D. B., Marks, J. D., Krishnada, Aparna, and Onyuksel, Hayat

Subjects
LIPOSOMES, EPIDERMAL growth factor, CANCER cells, CELL lines, DOXORUBICIN, VINORELBINE, GLIOMAS
Abstract

Presents the results of a study on epidermal growth factor receptor (EGFR)-targeted immunoliposomes (IL) with the potential to provide intracellular drug delivery to EGFR and EGFRvIII-overexpressing tumor cells. Details of the preparation of lipososomes; Background on the cell lines used in the study, including human glioblastoma U-87; Characteristics of the cytotoxicity of Il containing doxorubicin and vinorelbine against EGFR overexpressing cells.

Published
2004
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