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1. Disease applications of spinal cord stimulation: Chronic nonmalignant pain.

Author

Sammartino, Francesco, MacDonell, Jacquelyn, North, Richard, Krishna, Vibhor, and Poree, Lawrence

Subjects
Approved indications, Chronic pain, Neuromodulation, Neuropathy, Spinal Cord Stimulation, Humans, Spinal Cord Stimulation, Chronic Pain, Neuralgia, Pain Management
Abstract

Neuropathic pain is a chronic condition representing a significant burden for society. It is estimated 1 out of 10 people over the age of 30 that in the US have been diagnosed with neuropathic pain. Most of the available treatments for neuropathic pain have moderate efficacy over time which limit their use; therefore, other therapeutic approaches are needed for patients. Spinal cord stimulation is an established and cost-effective modality for treating severe chronic pain. In this article we will review the current approved indications for the use of spinal cord stimulation in the US and the novel therapeutic options which are now available using this therapy.

Published
2024

5. Vagus nerve stimulation paired with rehabilitation for stroke: Implantation experience from the VNS-REHAB trial

Author

Liu, Charles Y., Russin, Jonathan, Adelson, David P., Jenkins, Alistair, Hilmi, Omar, Brown, Benjamin, Lega, Bradley, Whitworth, Tony, Bhattacharyya, Dev, Schwartz, Theodore H., Krishna, Vibhor, Williams, Ziv, Uff, Christopher, Willie, Jon, Hoffman, Caitlin, Vandergrift, William A., Achrol, Achal Singh, Ali, Rushna, Konrad, Peter, Edmonds, Joseph, Kim, Daniel, Bhatt, Pragnesh, Tarver, Brent W., Pierce, David, Jain, Ravi, Burress, Chester, Casavant, Reema, Prudente, Cecília N., and Engineer, Navzer D.

Published
2022
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6. Probabilistic Refinement of Focused Ultrasound Thalamotomy Targeting for Parkinson's Disease Tremor.

Author

Cheyuo, Cletus, Germann, Jürgen, Yamamoto, Kazuaki, Zibly, Zion, Krishna, Vibhor, Sarica, Can, Borges, Yuri Ferreira Felloni, Vetkas, Artur, Kalia, Suneil K., Hodaie, Mojgan, Fasano, Alfonso, Schwartz, Michael L., Elias, W. Jeffrey, and Lozano, Andres M.

Abstract

Background: There remains high variability in clinical outcomes when the same magnetic resonance image‐guided focused ultrasound (MRgFUS) thalamotomy target is used for both essential tremor (ET) and tremor‐dominant Parkinson's disease (TDPD). Objective: Our goal is to refine the MRgFUS thalamotomy target for TDPD versus ET. Methods: We retrospectively performed voxel‐wise efficacy and structural connectivity mapping using 3‐12‐month post‐procedure hand tremor scores for a multicenter cohort of 32 TDPD patients and a previously published cohort of 79 ET patients, and 24‐hour T1‐weighted post‐MRgFUS brain images. We validated our findings using Unified Parkinson's Disease Rating Scale part III scores for an independent cohort of nine TDPD patients. Results: The post‐MRgFUS clinical improvements were 45.9% ± 35.9%, 55.5% ± 36%, and 46.1% ± 18.6% for ET, multicenter TDPD and validation TDPD cohorts, respectively. The TDPD and ET efficacy maps differed significantly (ppermute < 0.05), with peak TDPD improvement (87%) at x = −13.5; y = −15.0; z = 1.5, ~3.5 mm anterior and 3 mm dorsal to the ET target. Discriminative connectivity projections were to the motor and premotor regions in TDPD, and to the motor and somatosensory regions in ET. The disorder‐specific voxel‐wise efficacy map could be used to estimate outcome in TDPD patients with high accuracy (R = 0.8; R2 = 0.64; P < 0.0001). The model was validated using the independent cohort of nine TDPD patients (R = 0.73; R2 = 0.53; P = 0.025—voxel analysis). Conclusion: We demonstrated that the most effective MRgFUS thalamotomy target in TDPD is in the ventral intermediate nucleus/ventralis oralis posterior border region. This finding offers new insights into the thalamic regions instrumental in tremor control, with pivotal implications for improving treatment outcomes. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Real-world Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control: USA Experience (P1-3.007)

Author

Okun, Michael, primary, Foote, Kelly, additional, Zesiewicz, Theresa, additional, Bezchlibnyk, Yarema, additional, Papanastassiou, Alexander, additional, Castaneda, Juan Ramirez, additional, Carlson, Jonathan, additional, Aldred, Jason, additional, Krishna, Vibhor, additional, Luca, Corneliu, additional, Jagid, Jonathan, additional, Durphy, Jennifer, additional, Metman, Leonard Verhagen, additional, Sani, Sepehr, additional, Ojemann, Steven, additional, Kern, Drew, additional, Ramdhani, Ritesh, additional, Weintraub, David, additional, Siadati, Abdolreza, additional, Sundaram, Bharathy, additional, Zhao, Cong Zhi, additional, Martinez, Derek, additional, Siddiqui, Mustafa, additional, Tatter, Stephen, additional, Chen, Lilly, additional, and Goldberg, Edward, additional

Published
2024
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13. Reliable cognitive change following unilateral deep brain stimulation in essential tremor.

Author

Kielb, Stephanie, Speelman, Claire, Boxley, Laura, Aase, Darrin, Dawson, Erica, Changizi, Barbara, Merola, Aristide, Krishna, Vibhor, and Nguyen, Christopher

Subjects
DEEP brain stimulation, ESSENTIAL tremor, NEUROPSYCHOLOGICAL tests, MEASUREMENT errors, COGNITION disorders
Abstract

Objective: This retrospective analysis assessed regression-based reliable change (RC) of cognition in a sample of essential tremor (ET) patients who underwent unilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM-DBS). Method: Thirty patients (mean age at pre-evaluation = 70.4 ± 6.3 years) underwent neuropsychological evaluation pre- and post-unilateral VIM-DBS placement (mean time between pre and post-evaluation = 13.1 ± 4.0 months). Paired samples t-tests and RC analyses were employed. Results: No significant within-group differences were observed when cognitive scores were compared between evaluations. The vast majority of patients demonstrated stability across pre-and post-surgical evaluations (i.e. 29 out of 30); however, those with high-risk co-morbid medical conditions may be vulnerable to post-surgical cognitive decline as indicated by RC measures. Conclusions: The use of regression-based RC indices to assess individual cognitive changes between pre and post-surgical evaluations control for systematic and measurement errors that can occur over repeated evaluations, and may be able to identify cognitive changes that evade detection in traditional within-group comparisons. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Automated Motion Sensor‐Based Functional Mapping Improves Deep Brain Stimulation Programming Efficiency.

Author

Krishna, Vibhor, Hadley, Aaron, Englert, Danielle, Fleming, Nicholas, Walter, Benjamin L., Hennigs, Erica, Merola, Aristide, and Heldman, Dustin A.

Subjects
*DEEP brain stimulation, *WILCOXON signed-rank test, *PARKINSON'S disease, *GLOBUS pallidus, *MOTION detectors
Abstract

The article discusses the use of automated motion sensor-based functional mapping (SBFM) to improve deep brain stimulation (DBS) programming efficiency for patients with Parkinson's disease. A randomized trial compared SBFM programming with standard-of-care (SoC) programming and found that SBFM reduced the number of settings tested and showed similar clinical outcomes. While SBFM was not significantly faster than SoC, integrating the SBFM system with the DBS programmer could enhance programming efficiency in the future. The study suggests that SBFM can extend expert programming strategies to populations without access to specialized DBS centers, with potential for further improvements in future research. [Extracted from the article]

Published
2024
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18. Single neurons in the thalamus and subthalamic nucleus process cardiac and respiratory signals in humans.

Author

De Falco, Emanuela, Solcà, Marco, Bernasconi, Fosco, Babo-Rebelo, Mariana, Young, Nicole, Sammartino, Francesco, Tallon-Baudry, Catherine, Navarro, Vincent, Rezai, Ali R., Krishna, Vibhor, and Blanke, Olaf

Subjects
SUBTHALAMIC nucleus, DEEP brain stimulation, NEURONS, THALAMUS, CENTRAL nervous system, CARDIAC patients
Abstract

Visceral signals are constantly processed by our central nervous system, enable homeostatic regulation, and influence perception, emotion, and cognition. While visceral processes at the cortical level have been extensively studied using non-invasive imaging techniques, very few studies have investigated how this information is processed at the single neuron level, both in humans and animals. Subcortical regions, relaying signals from peripheral interoceptors to cortical structures, are particularly understudied and how visceral information is processed in thalamic and subthalamic structures remains largely unknown. Here, we took advantage of intraoperative microelectrode recordings in patients undergoing surgery for deep brain stimulation (DBS) to investigate the activity of single neurons related to cardiac and respiratory functions in three subcortical regions: ventral intermedius nucleus (Vim) and ventral caudalis nucleus (Vc) of the thalamus, and subthalamic nucleus (STN). We report that the activity of a large portion of the recorded neurons (about 70%) was modulated by either the heartbeat, the cardiac inter-beat interval, or the respiration. These cardiac and respiratory response patterns varied largely across neurons both in terms of timing and their kind of modulation. A substantial proportion of these visceral neurons (30%) was responsive to more than one of the tested signals, underlining specialization and integration of cardiac and respiratory signals in STN and thalamic neurons. By extensively describing single unit activity related to cardiorespiratory function in thalamic and subthalamic neurons, our results highlight the major role of these subcortical regions in the processing of visceral signals. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Real-World Outcomes in USA using DBS Systems with Directionality and Multiple Independent Current Control (P5-11.017)

Author

Okun, Michael, primary, Foote, Kelly, additional, Zesiewicz, Theresa, additional, Bezchlibnyk, Yarema, additional, Papanastassiou, Alexander, additional, Carlson, Jonathan, additional, Aldred, Jason, additional, Krishna, Vibhor, additional, Merola, Aristide, additional, Luca, Corneliu, additional, Jagid, Jonathan, additional, Durphy, Jennifer, additional, Metman, Leonard Verhagen, additional, Sani, Sepehr, additional, Ojemann, Steven, additional, Kern, Drew, additional, Weintraub, David, additional, Ramdhani, Ritesh, additional, Siadati, Abdolreza, additional, Sundaram, Bharathy, additional, Zhao, Cong Zhi, additional, Martinez, Derek, additional, Siddiqui, Mustafa, additional, Tatter, Stephen, additional, Chen, Lilly, additional, and Jain, Roshini, additional

Published
2023
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28. List of Contributors of Volume 1

Author

Ackermann, D. Michael, primary, Ajiboye, Abidemi B., additional, Allison, Brendan Z., additional, Barolat, Giancarlo, additional, Bhadra, Narendra, additional, Bhadra, Niloy, additional, Blaha, Charles D., additional, Bouton, Chad E., additional, Bradley, Kerry, additional, Capadona, Jeffrey R., additional, Cogan, Stuart F., additional, Cozzens, Jeffrey W., additional, Cusack, William, additional, D’Haese, Pierre-Francois, additional, Dawant, Benoit M., additional, de Groat, William C., additional, De Ridder, Dirk, additional, Denison, Timothy, additional, Dolce, Jeffery J., additional, Doleys, Daniel M., additional, Donoghue, John P., additional, E. Larsen, Lars, additional, Falowski, Steven M., additional, Foster, Allison, additional, Gauthier, Lynne V., additional, George, Lydia C., additional, Gomez, Christy, additional, Goodman, Amy M., additional, Grill, Warren M., additional, Gross, Robert E., additional, Guan, Yun, additional, Hara, Seth, additional, Harris, James, additional, He, Bin, additional, Herron, Jeffrey A., additional, Hoyen, Harry A., additional, Kaplitt, Michael G., additional, Keith, Michael W., additional, Kent, Alexander R., additional, Kilgore, Kevin L., additional, Kirsch, Robert F., additional, Kocharian, Gary, additional, Konrad, Peter E., additional, Kramer, Jeffery, additional, Krames, Elliot S., additional, Krishna, Vibhor, additional, Lee, Kendall H., additional, Linderoth, Bengt, additional, Ludwig, Kip A., additional, Machado, Andre G., additional, Madineni, Ravichandra, additional, Manker, Steve G., additional, McIntyre, Cameron C., additional, Mogilner, Alon Y., additional, Mortimer, John T., additional, Mosier, Elizabeth M., additional, North, Richard B., additional, Pancrazio, Joseph J., additional, Parker, John L., additional, Peckham, P. Hunter, additional, Pedersen, Nigel P., additional, Peterson, Erik J., additional, Pless, Benjamin, additional, Pulliam, Christopher L., additional, Rezai, Ali R., additional, Richter, Troy A., additional, Riley, Jonathan, additional, Rosenow, Joshua M., additional, Ross, Erika, additional, Sammartino, Francesco, additional, Schalk, Gerwin, additional, Schubauer, Kathryn M., additional, Sharan, Ashwini D., additional, Shellock, Frank G., additional, Shipley, Jane, additional, Shoffstall, Andrew, additional, Simpson, Brian, additional, Slavin, Konstantin V., additional, Stanton-Hicks, Michael, additional, Tai, Changfeng, additional, Taylor, Toacca, additional, Tomasiewicz, Hilarie C., additional, Tyler, Dustin J., additional, Vancamp, Tim, additional, Vanneste, Sven, additional, Vonck, Kristl E.J., additional, W. Clark, Shannon, additional, Weber, Doug, additional, Weiner, Richard L., additional, Wolfson, Michael, additional, Wu, Chengyuan, additional, Ye, Donald Y., additional, Yin, Dali, additional, and Yin, Hang, additional

Published
2018
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30. List of Contributors of Volume 2

Author

Adnan, Al-Kaisy, primary, Alexopoulos, Andreas, additional, Alo, Kenneth M., additional, Alterman, Ron L., additional, Amar, Arun, additional, Andrade, Pablo, additional, Arulkumar, Sailesh, additional, Awad, Ahmed J., additional, Baltuch, Gordon, additional, Barolat, Giancarlo, additional, Barthélemy, Ernest J., additional, Barua, Neil U., additional, Bennett, Maria E., additional, Bentley, Nicole, additional, Bezchlibnyk, Yarema B., additional, Bijanki, Kelly R., additional, Bingaman, William, additional, Boggs, Joseph W., additional, Boon, Paul, additional, Brouwer, Brigitte A., additional, Campos, Lucas W., additional, Caparso, Anthony, additional, Capozzo, Annamaria, additional, Chae, John, additional, Chang, Jin Woo, additional, Cheng, Jennifer, additional, Copenhaver, David, additional, Deer, Timothy R., additional, Deogaonkar, Milind, additional, Dhar, Deepali, additional, Dohmeier, Keeley, additional, Dougherty, Darin D., additional, Durand, Dominique M., additional, Foote, Kelly, additional, Gilligan, Jeffrey, additional, Gill, Steven S., additional, Gonzalez-Martinez, Jorge, additional, Greenberg, Benjamin D., additional, Gross, Robert E., additional, H. Pourfar, Michael, additional, Hamani, Clement, additional, Hayek, Salim M., additional, Holtzheimer, Paul E., additional, Ilfeld, Brian M., additional, Jin, Haiyan, additional, Joosten, Bert, additional, Jung, Na Young, additional, Kim, Chong H., additional, Kim, Young Goo, additional, Klehr, Martin, additional, Koch, Paul, additional, Kohl, Sina, additional, Kopell, Brian H., additional, Kramer, Daniel, additional, Krames, Elliot S., additional, Krishnan, Balu, additional, Krishna, Vibhor, additional, Kuhn, Jens, additional, Kyung-soo Hong, Jason, additional, Leonardo, Kapural, additional, Leong, Michael S., additional, Li, Dianyou, additional, Linninger, Andreas A., additional, Lipsman, Nir, additional, Liu, Charles, additional, Lozano, Andres M., additional, Mackow, Michael, additional, Malinowski, Mark N., additional, Mayberg, Helen S., additional, Mazzone, Paolo, additional, Mehta, Ankit I., additional, Mehta, Vivek, additional, Mills-Joseph, Reversa, additional, Nair, Dileep, additional, North, Richard B., additional, Okun, Michael, additional, Patel, Nikunj K., additional, Patil, Parag G., additional, Pope, Jason E., additional, Poree, Lawrence R., additional, Prager, Joshua P., additional, Raedt, Robrecht, additional, Rasouli, Jonathan J., additional, Rasskazoff, Serge, additional, Rauck, Richard, additional, Reeves, Kevin, additional, Rezai, Ali R., additional, Russin, Jonathan, additional, Sabersky, Abraham, additional, Saulino, Michael, additional, Scarnati, Eugenio, additional, Schu, Stefan, additional, Sharma, Mayur, additional, Shipley, Jane, additional, Shirvalkar, Prasad, additional, Slavin, Konstantin V., additional, Stanton-Hicks, Michael, additional, Stone, Scellig, additional, Stuart, William A., additional, Sun, Bomin, additional, Tangen, Kevin, additional, Tepper, Stewart J., additional, van Kleef, Maarten, additional, Vancamp, Tim, additional, Verrills, Paul, additional, Viselli, Fabio, additional, Visser-Vandewalle, Veerle, additional, Vitale, Flora, additional, Vonck, Kristl, additional, Wang, Tao, additional, Wang, Xuelian, additional, Weiner, Richard L., additional, Widge, Alik S., additional, Wongsarnpigoon, Amorn, additional, Y. Mogilner, Alon, additional, Yaeger, Kurt A., additional, Yaksh, Tony L., additional, Yin, Dali, additional, Zeljic, Kristina, additional, Zhang, Chencheng, additional, and Zhan, Shikun, additional

Published
2018
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33. Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

Author

Krishna, Vibhor, primary, Fishman, Paul S., additional, Eisenberg, Howard M., additional, Kaplitt, Michael, additional, Baltuch, Gordon, additional, Chang, Jin Woo, additional, Chang, Wei-Chieh, additional, Martinez Fernandez, Raul, additional, del Alamo, Marta, additional, Halpern, Casey H., additional, Ghanouni, Pejman, additional, Eleopra, Roberto, additional, Cosgrove, Rees, additional, Guridi, Jorge, additional, Gwinn, Ryder, additional, Khemani, Pravin, additional, Lozano, Andres M., additional, McDannold, Nathan, additional, Fasano, Alfonso, additional, Constantinescu, Marius, additional, Schlesinger, Ilana, additional, Dalvi, Arif, additional, and Elias, W. Jeff, additional

Published
2023
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34. Focused ultrasound–mediated blood-brain barrier opening in Alzheimer’s disease: long-term safety, imaging, and cognitive outcomes

Author

Rezai, Ali R., primary, Ranjan, Manish, additional, Haut, Marc W., additional, Carpenter, Jeffrey, additional, D’Haese, Pierre-François, additional, Mehta, Rashi I., additional, Najib, Umer, additional, Wang, Peng, additional, Claassen, Daniel O., additional, Chazen, J. Levi, additional, Krishna, Vibhor, additional, Deib, Gerard, additional, Zibly, Zion, additional, Hodder, Sally L., additional, Wilhelmsen, Kirk C., additional, Finomore, Victor, additional, Konrad, Peter E., additional, Kaplitt, Michael, additional, and _, _, additional

Published
2022
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37. Focused ultrasound–mediated blood-brain barrier opening in Alzheimer’s disease: long-term safety, imaging, and cognitive outcomes.

Author

Rezai, Ali R., Ranjan, Manish, Haut, Marc W., Carpenter, Jeffrey, D’Haese, Pierre-François, Mehta, Rashi I., Najib, Umer, Wang, Peng, Claassen, Daniel O., Chazen, J. Levi, Krishna, Vibhor, Deib, Gerard, Zibly, Zion, Hodder, Sally L., Wilhelmsen, Kirk C., Finomore, Victor, Konrad, Peter E., and Kaplitt, Michael

Published
2023
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44. ID: 309438 Real-World Outcomes Using DBS Systems With Directionality and Multiple Independent Current Control: USA Experience

Author

Okun, Michael, Foote, Kelly, Zesiewicz, Theresa, Bezchlibnyk, Yarema, Papanastassiou, Alexander, Ramirez-Castaneda, Juan, Carlson, Jonathan, Aldred, Jason, Krishna, Vibhor, Luca, Corneliu, Jagid, Jonathan, Durphy, Jennifer, Verhagen-Metman, Leo, Sani, Sepehr, Ojemann, Steven, Kern, Drew, Weintraub, David, Ramdhani, Ritesh, Siadati, Abdolreza, Sundaram, Bharathy, Zhao, Cong Zhi, Martinez, Derek, Siddiqui, Mustafa, Tatter, Stephen, and Chen, Lilly

Published
2024
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