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253 results on '"Krim, Selim R."'

14. Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial

Author

Lindenfeld, JoAnn, Zile, Michael R, Desai, Akshay S, Bhatt, Kunjan, Ducharme, Anique, Horstmanshof, Douglas, Krim, Selim R, Maisel, Alan, Mehra, Mandeep R, Paul, Sara, Sears, Samuel F, Sauer, Andrew J, Smart, Frank, Zughaib, Marcel, Castaneda, Paige, Kelly, Jean, Johnson, Nessa, Sood, Poornima, Ginn, Greg, Henderson, John, Adamson, Philip B, and Costanzo, Maria Rosa

Published
2021
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17. Regional differences in use and outcomes of left ventricular assist devices: Insights from the Interagency Registry for Mechanically Assisted Circulatory Support Registry

Author

Krim, Selim R, Vivo, Rey P, Campbell, Patrick, Estep, Jerry D, Fonarow, Gregg C, Naftel, David C, and Ventura, Hector O

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Bioengineering, Assistive Technology, Rehabilitation, Good Health and Well Being, Female, Heart Failure, Heart-Assist Devices, Humans, Male, Middle Aged, Registries, Survival Rate, Time Factors, Treatment Outcome, United States, continuous-flow, left ventricular assist device, INTERMACS, bridge to transplant, destination therapy, mechanical circulatory support, regions, outcomes, Cardiorespiratory Medicine and Haematology, Surgery, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundWe examined whether characteristics, implant strategy, and outcomes in patients who receive continuous-flow left ventricular assist devices (CF-LVAD) differ across geographic regions in the United States.MethodsA total of 7,404 CF-LVAD patients enrolled in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) from 134 participating institutions were analyzed from 4 distinct regions: Northeast, 2,605 (35%); Midwest, 2,210 (30%); West, 973 (13%); and South, 1,616 (22%).ResultsAt baseline, patients in the Northeast and South were more likely to have INTERMACS risk profiles 1 and 2. A bridge-to-transplant (BTT) strategy was more common in the Northeast (31.7%; West, 18.5%; South, 26.9%; Midwest, 25.5%; p < 0.0001). In contrast, destination therapy (DT) was more likely in the South (40.6%; Northeast, 32.3%; Midwest, 27.3%; West, 27.3%; p < 0.0001). Although all regions showed a high 1-year survival rate, some regional differences in long-term mortality were observed. Notably, survival beyond 1 year after LVAD implant was significantly lower in the South. However, when stratified by device strategy, no significant differences in survival for BTT or DT patients were found among the regions. Finally, with the exception of right ventricular failure, which was more common in the South, no other significant differences in causes of death were observed among the regions.ConclusionsRegional differences in clinical profile and LVAD strategy exist in the United States. Despite an overall high survival rate at 1 year, differences in mortality among the regions were noted. The lower survival rate in the South may be attributed to patient characteristics and higher use of LVAD as DT.

Published
2015

18. Short- and long-term rehospitalization and mortality for heart failure in 4 racial/ethnic populations.

Author

Vivo, Rey P, Krim, Selim R, Liang, Li, Neely, Megan, Hernandez, Adrian F, Eapen, Zubin J, Peterson, Eric D, Bhatt, Deepak L, Heidenreich, Paul A, Yancy, Clyde W, and Fonarow, Gregg C

Subjects
Humans, Hospitalization, Length of Stay, Patient Readmission, Geriatric Assessment, Severity of Illness Index, Registries, Hospital Mortality, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Retrospective Studies, Time Factors, Aged, Aged, 80 and over, African Americans, Asian Americans, European Continental Ancestry Group, Hispanic Americans, Medicare, United States, Female, Male, Heart Failure, health policy and outcome research, heart failure, race/ethnicity, rehospitalization, Cardiorespiratory Medicine and Haematology
Abstract

BackgroundThe degree to which outcomes following hospitalization for acute heart failure (HF) vary by racial and ethnic groups is poorly characterized. We sought to compare 30-day and 1-year rehospitalization and mortality rates for HF among 4 race/ethnic groups.Methods and resultsUsing the Get With The Guidelines-HF registry linked with Medicare data, we compared 30-day and 1-year outcomes between racial/ethnic groups by using a multivariable Cox proportional hazards model adjusting for clinical, hospital, and socioeconomic status characteristics. We analyzed 47 149 Medicare patients aged ≥65 years who had been discharged for HF between 2005 and 2011: there were 39 213 whites (83.2%), 4946 blacks (10.5%), 2347 Hispanics (5.0%), and 643 Asians/Pacific Islanders (1.4%). Relative to whites, blacks and Hispanics had higher 30-day and 1-year unadjusted readmission rates but lower 30-day and 1-year mortality; Asians had similar 30-day readmission rates but lower 1-year mortality. After risk adjustment, blacks had higher 30-day and 1-year CV readmission than whites but modestly lower short- and long-term mortality; Hispanics had higher 30-day and 1-year readmission rates and similar 1-year mortality than whites, while Asians had similar outcomes. When socioeconomic status data were added to the model, the majority of associations persisted, but the difference in 30-day and 1-year readmission rates between white and Hispanic patients became nonsignificant.ConclusionsAmong Medicare patients hospitalized with HF, short- and long-term readmission rates and mortality differed among the 4 major racial/ethnic populations and persisted even after controlling for clinical, hospital, and socioeconomic status variables.

Published
2014

19. Torsemide vs Furosemide Among Patients With New-Onset vs Worsening Chronic Heart Failure

Author

Krim, Selim R., primary, Anand, Senthil, additional, Greene, Stephen J., additional, Chen, Anqi, additional, Wojdyla, Daniel, additional, Vilaro, Juan, additional, Haught, Herbert, additional, Herre, John M., additional, Eisenstein, Eric L., additional, Anstrom, Kevin J., additional, Pitt, Bertram, additional, Velazquez, Eric J., additional, and Mentz, Robert J., additional

Published
2023
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23. Outcomes of Patients with Left Ventricular Assist Devices Requiring Intermittent Hemodialysis: Single Center Cohort, Systematic Review, and Individual-Participant Data Meta-Analysis

Author

daSilva-deAbreu, Adrian, primary, Faaborg-Andersen, Christian, additional, Joury, Abdulaziz, additional, Tutor, Austin, additional, Desai, Sapna, additional, Eiswirth, Clement, additional, Krim, Selim R., additional, Wever-Pinzon, James, additional, Lavie, Carl J., additional, and Ventura, Hector O., additional

Published
2023
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