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189 results on '"Kriel, Robert L."'

12. Automatic garage door openers: hazard for children

Author

Kriel, Robert L., Gormley, Mark E., Krach, Linda E., Luxenberg, Michael G., Bartsh, Shawn M., and Bertrand, Jolene R.

Subjects
Garage doors -- Radio control, Children's accidents -- Prevention
Abstract

A few simple tests can help evaluate the safety of automatic garage door openers. Since 1974, at least 85 children in the United States have died or sustained permanent brain damage due to automatic garage door openers. Tests using a wood block, a paper towel roll, and a child-sized doll found that 88% of 50 garage door openers reversed when encountering the wood block while only 40% reversed when encountering the doll. Children have activated the automatic mechanism in most reported injuries. In one report, however, an adult activated the mechanism and left before the child became entrapped., ABSTRACT. Objectives. Despite significant advances in automatic garage door opener design, automatic garage door openers continue to severely injure or kill children. In this investigation, we sought to determine the [...]

Published
1996

29. A Pilot Study Assessing Pharmacokinetics and Tolerability of Oral and Intravenous Baclofen in Healthy Adult Volunteers.

Author

Agarwal, Suresh K., Kriel, Robert L., Cloyd, James C., Coles, Lisa D., Scherkenbach, Lisa A., Tobin, Michael H., and Krach, Linda E.

Subjects
*DRUG metabolism, *PILOT projects, *EYE movement disorders, *NYSTAGMUS, *CARDIOVASCULAR system
Abstract

Our objective was to characterize baclofen pharmacokinetics and safety given orally and intravenously. Twelve healthy subjects were enrolled in a randomized, open-label, crossover study and received single doses of baclofen: 3 or 5 mg given intravenously and 5 or 10 mg taken orally with a 48-hour washout. Blood samples for baclofen analysis were collected pre-dose and at regular intervals up to 24 hours post-dose. Clinical response was assessed by sedation scores, ataxia, and nystagmus. Mean absolute bioavailability of oral baclofen was 74%. Dose-adjusted areas under the curve between the oral and intravenous arms were statistically different (P = .0024), whereas area under the curve variability was similar (coefficient of variation: 18%-24%). Adverse effects were mild in severity and not related to either dose or route of administration. Three- and 5-mg intravenous doses of baclofen were well tolerated. Seventy-four percent oral bioavailability indicates that smaller doses of intravenous baclofen are needed to attain comparable total drug exposures. [ABSTRACT FROM AUTHOR]

Published
2015
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30. GMFM 1 year after continuous intrathecal baclofen infusion

Author

Krach, Linda E., primary, Kriel, Robert L., additional, Gilmartin, Richard C., additional, Swift, Dale M., additional, Storrs, Bruce B., additional, Abbott, Rick, additional, Ward, John D., additional, Bloom, Karen K., additional, Brooks, William H., additional, Madsen, Joseph R., additional, McLaughlin, John F., additional, and Nadell, Joseph M., additional

Published
2005
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45. How the internet could help Cuba more in health research

Author

Stusser, Rodolfo J., Kriel, Robert L., Dickey, Richard A., and Krach, Linda E.

Subjects
Medical research -- International aspects, Medical research -- Technology application, Medicine, Experimental -- International aspects, Medicine, Experimental -- Technology application, Technology application
Published
2004

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