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5. The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET

Author

Talarico, Rosaria, Aguilera, Silvia, Alexander, Tobias, Amoura, Zahir, Antunes, Ana M., Arnaud, Laurent, Avcin, Tadej, Beretta, Lorenzo, Bombardieri, Stefano, Burmester, Gerd R., Cannizzo, Sara, Cavagna, Lorenzo, Chaigne, Benjamin, Cornet, Alain, Costedoat-Chalumeau, Nathalie, Doria, Andrea, Ferraris, Alessandro, Fischer-Betz, Rebecca, Fonseca, João E., Frank, Charissa, Gaglioti, Andrea, Galetti, Ilaria, Grunert, Jürgen, Guimarães, Vera, Hachulla, Eric, Houssiau, Frederic, Iaccarino, Luca, Krieg, Thomas M., Limper, Marteen, Malfait, Fransiska, Mariette, Xavier, Marinello, Diana, Martin, Thierry, Matthews, Lisa, Matucci-Cerinic, Marco, Meyer, Alain, Montecucco, Carlomaurizio, Mouthon, Luc, Müller-Ladner, Ulf, Rednic, Simona, Romão, Vasco C., Schneider, Matthias, Smith, Vanessa, Sulli, Alberto, Tamirou, Farah, Taruscio, Domenica, Taulaigo, Anna V., Terol, Enrique, Tincani, Angela, Ticciati, Simone, Turchetti, Giuseppe, van Hagen, P. Martin, van Laar, Jacob M., Vieira, Ana, de Vries-Bouwstra, Jeska K., Cutolo, Maurizio, Mosca, Marta, Talarico, Rosaria, Aguilera, Silvia, Alexander, Tobias, Amoura, Zahir, Antunes, Ana M., Arnaud, Laurent, Avcin, Tadej, Beretta, Lorenzo, Bombardieri, Stefano, Burmester, Gerd R., Cannizzo, Sara, Cavagna, Lorenzo, Chaigne, Benjamin, Cornet, Alain, Costedoat-Chalumeau, Nathalie, Doria, Andrea, Ferraris, Alessandro, Fischer-Betz, Rebecca, Fonseca, João E., Frank, Charissa, Gaglioti, Andrea, Galetti, Ilaria, Grunert, Jürgen, Guimarães, Vera, Hachulla, Eric, Houssiau, Frederic, Iaccarino, Luca, Krieg, Thomas M., Limper, Marteen, Malfait, Fransiska, Mariette, Xavier, Marinello, Diana, Martin, Thierry, Matthews, Lisa, Matucci-Cerinic, Marco, Meyer, Alain, Montecucco, Carlomaurizio, Mouthon, Luc, Müller-Ladner, Ulf, Rednic, Simona, Romão, Vasco C., Schneider, Matthias, Smith, Vanessa, Sulli, Alberto, Tamirou, Farah, Taruscio, Domenica, Taulaigo, Anna V., Terol, Enrique, Tincani, Angela, Ticciati, Simone, Turchetti, Giuseppe, van Hagen, P. Martin, van Laar, Jacob M., Vieira, Ana, de Vries-Bouwstra, Jeska K., Cutolo, Maurizio, and Mosca, Marta

Published
2021

9. Whole blood gene expression profiling distinguishes systemic sclerosis‐overlap syndromes from other subsets

Author

Moinzadeh, P., Frommolt, Peter, Franitza, M., Toliat, Mohammad Reza, Becker, K., Nürnberg, Peter, Nihtyanova, Svetlana I., Ahrazoglu, M., Belz, Doreen, Hunzelmann, N., Abraham, D., Ong, V. H., Mouthon, L., Hesselstrand, R., Denton, C. P., Krieg, Thomas M., Moinzadeh, P., Frommolt, Peter, Franitza, M., Toliat, Mohammad Reza, Becker, K., Nürnberg, Peter, Nihtyanova, Svetlana I., Ahrazoglu, M., Belz, Doreen, Hunzelmann, N., Abraham, D., Ong, V. H., Mouthon, L., Hesselstrand, R., Denton, C. P., and Krieg, Thomas M.

Published
2020

10. Role of collagen XII in skin homeostasis and repair

Author

Schönborn, Katrin, Willenborg, Sebastian, Schulz, Jan-Niklas, Imhof, Thomas, Eming, Sabine A., Quondamatteo, Fabio, Brinckmann, Jürgen, Niehoff, Anja, Paulsson, Mats, Koch, Manuel, Eckes, Beate, Krieg, Thomas M., Schönborn, Katrin, Willenborg, Sebastian, Schulz, Jan-Niklas, Imhof, Thomas, Eming, Sabine A., Quondamatteo, Fabio, Brinckmann, Jürgen, Niehoff, Anja, Paulsson, Mats, Koch, Manuel, Eckes, Beate, and Krieg, Thomas M.

Published
2020

12. European Dermatology Forum S1‐guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes

Author

Knobler, Robert, Moinzadeh, Pia, Hunzelmann, Nicolas, Kreuter, Alexander, Cozzio, A., Mouthon, L., Cutolo, M., Rongioletti, Franco, Denton, C.P., Rudnicka, Lidia, Frasin, L.A., Smith, V., Gabrielli, A., Aberer, Elisabeth, Bagot, M., Bali, G., Bouaziz, J., Braae Olesen, A., Foeldvari, Ivan, Frances, C., Jalili, A., Just, U., Kähäri, V., Karpati, Sarolta, Kofoed, K., Krasowska, D., Olszewska, M., Orteu, C., Panelius, J., Parodi, A., Petit, A., Quaglino, P., Ranki, A., Sanchez Schmidt, J.M., Seneschal, J., Skrok, A., Sticherling, M., Sunderkötter, C., Taieb, A., Tanew, A., Wolf, P., Worm, Margitta, Wutte, N.J., Krieg, Thomas M., Knobler, Robert, Moinzadeh, Pia, Hunzelmann, Nicolas, Kreuter, Alexander, Cozzio, A., Mouthon, L., Cutolo, M., Rongioletti, Franco, Denton, C.P., Rudnicka, Lidia, Frasin, L.A., Smith, V., Gabrielli, A., Aberer, Elisabeth, Bagot, M., Bali, G., Bouaziz, J., Braae Olesen, A., Foeldvari, Ivan, Frances, C., Jalili, A., Just, U., Kähäri, V., Karpati, Sarolta, Kofoed, K., Krasowska, D., Olszewska, M., Orteu, C., Panelius, J., Parodi, A., Petit, A., Quaglino, P., Ranki, A., Sanchez Schmidt, J.M., Seneschal, J., Skrok, A., Sticherling, M., Sunderkötter, C., Taieb, A., Tanew, A., Wolf, P., Worm, Margitta, Wutte, N.J., and Krieg, Thomas M.

Published
2017

13. Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis

Author

Schiller, Herbert B., Mayr, Christoph H., Leuschner, Gabriela, Strunz, Maximilian, Staab-Weijnitz, Claudia, Preisendörfer, Stefan, Eckes, Beate, Moinzadeh, Pia, Krieg, Thomas M., Schwartz, David A., Hatz, Rudolf A., Behr, Jürgen, Mann, Matthias, Eickelberg, Oliver, Schiller, Herbert B., Mayr, Christoph H., Leuschner, Gabriela, Strunz, Maximilian, Staab-Weijnitz, Claudia, Preisendörfer, Stefan, Eckes, Beate, Moinzadeh, Pia, Krieg, Thomas M., Schwartz, David A., Hatz, Rudolf A., Behr, Jürgen, Mann, Matthias, and Eickelberg, Oliver

Published
2017

15. European dermatology forum S1‐guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis

Author

Knobler, Robert, Moinzadeh, Pia, Hunzelmann, Nicolas, Kreuter, Alexander, Cozzio, A., Mouthon, L., Cutolo, M., Rongioletti, Franco, Denton, C.P., Rudnicka, Lidia, Frasin, L.A., Smith, V., Gabrielli, A., Aberer, Elisabeth, Bagot, M., Bali, G., Bouaziz, J., Braae Olesen, A., Foeldvari, Ivan, Frances, C., Jalili, A., Just, U., Kähäri, Veli-Matti, Karpati, Sarolta, Kofoed, K., Krasowska, D., Olszewska, M., Orteu, C., Panelius, J., Parodi, A., Petit, A., Quaglino, P., Ranki, A., Sanchez Schmidt, J.M., Seneschal, J., Skrok, A., Sticherling, M., Sunderkötter, C., Taieb, A., Tanew, A., Wolf, P., Worm, Margitta, Wutte, N.J., Krieg, Thomas M., Knobler, Robert, Moinzadeh, Pia, Hunzelmann, Nicolas, Kreuter, Alexander, Cozzio, A., Mouthon, L., Cutolo, M., Rongioletti, Franco, Denton, C.P., Rudnicka, Lidia, Frasin, L.A., Smith, V., Gabrielli, A., Aberer, Elisabeth, Bagot, M., Bali, G., Bouaziz, J., Braae Olesen, A., Foeldvari, Ivan, Frances, C., Jalili, A., Just, U., Kähäri, Veli-Matti, Karpati, Sarolta, Kofoed, K., Krasowska, D., Olszewska, M., Orteu, C., Panelius, J., Parodi, A., Petit, A., Quaglino, P., Ranki, A., Sanchez Schmidt, J.M., Seneschal, J., Skrok, A., Sticherling, M., Sunderkötter, C., Taieb, A., Tanew, A., Wolf, P., Worm, Margitta, Wutte, N.J., and Krieg, Thomas M.

Published
2017

17. The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase‐1 antibodies

Author

Hunzelmann, Nicolas, Riemekasten, G., Becker, M.O., Moinzadeh, Pia, Kreuter, Alexander, Melchers, I., Müller‐Ladner, Ulf, Meier, Friedegund, Worm, Margitta, Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Günther, C., Sardy, Miklos, Burkhardt, H., Koehm, M., Kuhr, K., Krieg, Thomas M., Sunderkötter, C., Hunzelmann, Nicolas, Riemekasten, G., Becker, M.O., Moinzadeh, Pia, Kreuter, Alexander, Melchers, I., Müller‐Ladner, Ulf, Meier, Friedegund, Worm, Margitta, Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Günther, C., Sardy, Miklos, Burkhardt, H., Koehm, M., Kuhr, K., Krieg, Thomas M., and Sunderkötter, C.

Published
2016

18. German guidelines for the diagnosis and therapy of localized scleroderma

Author

Kreuter, Alexander, Krieg, Thomas M., Worm, Margitta, Wenzel, Jörg, Moinzadeh, Pia, Kuhn, Annegret, Aberer, Elisabeth, Scharffetter‐Kochanek, Karin, Horneff, Gerd, Reil, Emma, Weberschock, Tobias, Hunzelmann, Nicolas, Kreuter, Alexander, Krieg, Thomas M., Worm, Margitta, Wenzel, Jörg, Moinzadeh, Pia, Kuhn, Annegret, Aberer, Elisabeth, Scharffetter‐Kochanek, Karin, Horneff, Gerd, Reil, Emma, Weberschock, Tobias, and Hunzelmann, Nicolas

Published
2016

19. COMP-assisted collagen secretion - a novel intracellular function required for fibrosis

Author

Schulz, Jan-Niklas, Nüchel, Julian Maria, Niehoff, Anja, Bloch, Wilhelm, Schönborn, Katrin, Hayashi, Shujiro, Kamper, Matthias, Brinckmann, Jürgen, Plomann, Markus, Paulsson, Mats, Krieg, Thomas M., Zaucke, Frank, Eckes, Beate, Schulz, Jan-Niklas, Nüchel, Julian Maria, Niehoff, Anja, Bloch, Wilhelm, Schönborn, Katrin, Hayashi, Shujiro, Kamper, Matthias, Brinckmann, Jürgen, Plomann, Markus, Paulsson, Mats, Krieg, Thomas M., Zaucke, Frank, and Eckes, Beate

Published
2016

20. Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis

Author

Khanna, Dinesh, Denton, Christopher P., Merkel, Peter A., Krieg, Thomas M., Le Brun, Franck-Olivier, Marr, Angelina, Papadakis, Kelly, Pope, Janet, Matucci-Cerinic, Marco, Furst, Daniel E., Khanna, Dinesh, Denton, Christopher P., Merkel, Peter A., Krieg, Thomas M., Le Brun, Franck-Olivier, Marr, Angelina, Papadakis, Kelly, Pope, Janet, Matucci-Cerinic, Marco, and Furst, Daniel E.

Published
2016

22. Effect of macitentan on the development of new ischemic digital ulcers in patients with systemic sclerosis: Dual-1 and Dual-2 randomized clinical trials

Author

Khanna, Dinesh, Denton, Christopher P., Merkel, Peter A., Krieg, Thomas M., Le Brun, Franck Olivier, Marr, Angelina, Papadakis, Kelly, Pope, Janet, Matucci Cerinic, Marco, Furst, Daniel E., Zochling, Jane, Stevens, Wendy, Proudman, Susanna, Feenstra, John, Youssef, Peter, Soroka, Nikolay, Tyabut, Tamara, Mikhailova, Elena Ivanovna, Rashkov, Rasho, Batalov, Anasta, Yablanski, Kiril, Keystone, Edward, Jones, Niall, Dunne, Jame, Masetto, Ariel, Calabresse, Renato Jiménez, Cabezas, Pedro Claudio Miranda, Silva, Marta Ofelia Aliste, Sariego, Imgadt Annelise Goecke, Escalente, William José Otero, Anić, Branimir, Kaliterna, Dušanka Martinović, Morović Vergles, Jadranka, Novak, Srdan, Prus, Višnja, Artuković, Marinko, Soukup, Tomaáš, Bečvař, Radim, Fojtík, Zdeněk, Mouthon, Luc, Kollert, Florian, Riemekasten, Gabriela, Lahner, Nina, Fierlbeck, Gerhard, Ahmadi Simab, Keihan, Diehm, Curt, Szücs, Gabriella, Kumánovics, Gábor, Nagy, György, Pal, Sarvajeet, Veeravalli, Sarath Chandra Mouli, Danda, Debashish, Ferri, Clodeveo, Cozzi, Franco, Ferraccioli, Gianfranco, Wiland, Piotr, Rudnicak, Lidia, Zwolak, Robert, Roszkiewicz, Jadwiga, Oleynikov, Valentin, Nikulenkova, Natalya, Lesnyak, Olga, Kaydashev, Igor, Kurytar, Oleksandr, Piura, Olena, Chopyak, Valentyna, Chatterjee, Soumya, Hsu, Vivien, Hummers, Laura, Martin, Richard, Domsic, Robyn, Schiopu, Elena, Shanahan, Joseph, Murphy, Frederik T., Kaine, Jeffrey, Davis, William, Grau, Rafael, Eimon, Alicia, Catoggio, Luis Jose, Laborde, Hugo Armando, Caeiro, Francisco, Savio, Veronica Gabriela, Amitrano, Cristina Beatriz, Vanthuyne, Marie, Zeng, Xioafeng, Zhang, Xiao, Zhu, Ping, Velásquez Franco, Carlos Jaime, Choueka, Philippe Selim Chalem, Sanchez, Patricia Julieta Vélez, Hermann, Walter, Sticherling, Michael, Steinbrink, Kerstin, Hein, Rüdiger, Aschoff, Roland, Sfikakis, Petro, Settas, Luka, Fraser, Alexander, Veale, Dougla, Balbir Gurman, Alexandra, Lidar, Merav, Litinsky, Irena, Levy, Yair, Carrillo Vazquez, Sandra Miriam, Rodriguez Reyna, Tatiana, Medrano Ramirez, Gabriel, Morales Torres, Jorge, Pacheco Tena, Cesar Francisco, Sanchez Ortiz, Adriana, Vonk, Madelon C., Stebbings, Simon, Solanki, Kamal, Steele, Richard, Ng, Kristine, Zubrzycka Sienkiewicz, Anna, Brzosko, Marek, Szepietowski, Jacek C., Hrycaj, Pawel, Da Silva, Ivone Fernandes Santo, Dos Santos, Lelita Da Conceiçao, Coelho, Paulo Jorge Clemente, Rios, Grissel, Chernykh, Tatiana, Grunina, Elena, Stanislav, Marina, Ally, Mahmood, Kalla, Asgar, Birlik, Ahmet Merih, Kovalenko, Volodymyr, Petrov, Andriy, Shevchuk, Sergiy, Stanislavchuk, Mykola, Anderson, Marina, Herrick, Ariane, Belch, Jill, Chung, Lorinda, Csuka, Mary Ellen, Frech, Tracy, Goldberg, Avram, Kahaleh, Bashar, Mayes, Maureen D., Rothfield, Naomi, Simms, Robert William, Spiera, Robert, Steen, Virgina, Varga, John, Sikes, David, Derk, Chris T., Kohen, Michael D., Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), Khanna, Dinesh, Denton, Christopher P., Merkel, Peter A., Krieg, Thomas M., Le Brun, Franck Olivier, Marr, Angelina, Papadakis, Kelly, Pope, Janet, Matucci Cerinic, Marco, Furst, Daniel E., Zochling, Jane, Stevens, Wendy, Proudman, Susanna, Feenstra, John, Youssef, Peter, Soroka, Nikolay, Tyabut, Tamara, Mikhailova, Elena Ivanovna, Rashkov, Rasho, Batalov, Anasta, Yablanski, Kiril, Keystone, Edward, Jones, Niall, Dunne, Jame, Masetto, Ariel, Calabresse, Renato Jiménez, Cabezas, Pedro Claudio Miranda, Silva, Marta Ofelia Aliste, Sariego, Imgadt Annelise Goecke, Escalente, William José Otero, Anić, Branimir, Kaliterna, Dušanka Martinović, Morović Vergles, Jadranka, Novak, Srdan, Prus, Višnja, Artuković, Marinko, Soukup, Tomaáš, Bečvař, Radim, Fojtík, Zdeněk, Mouthon, Luc, Kollert, Florian, Riemekasten, Gabriela, Lahner, Nina, Fierlbeck, Gerhard, Ahmadi Simab, Keihan, Diehm, Curt, Szücs, Gabriella, Kumánovics, Gábor, Nagy, György, Pal, Sarvajeet, Veeravalli, Sarath Chandra Mouli, Danda, Debashish, Ferri, Clodeveo, Cozzi, Franco, Ferraccioli, Gianfranco, Wiland, Piotr, Rudnicak, Lidia, Zwolak, Robert, Roszkiewicz, Jadwiga, Oleynikov, Valentin, Nikulenkova, Natalya, Lesnyak, Olga, Kaydashev, Igor, Kurytar, Oleksandr, Piura, Olena, Chopyak, Valentyna, Chatterjee, Soumya, Hsu, Vivien, Hummers, Laura, Martin, Richard, Domsic, Robyn, Schiopu, Elena, Shanahan, Joseph, Murphy, Frederik T., Kaine, Jeffrey, Davis, William, Grau, Rafael, Eimon, Alicia, Catoggio, Luis Jose, Laborde, Hugo Armando, Caeiro, Francisco, Savio, Veronica Gabriela, Amitrano, Cristina Beatriz, Vanthuyne, Marie, Zeng, Xioafeng, Zhang, Xiao, Zhu, Ping, Velásquez Franco, Carlos Jaime, Choueka, Philippe Selim Chalem, Sanchez, Patricia Julieta Vélez, Hermann, Walter, Sticherling, Michael, Steinbrink, Kerstin, Hein, Rüdiger, Aschoff, Roland, Sfikakis, Petro, Settas, Luka, Fraser, Alexander, Veale, Dougla, Balbir Gurman, Alexandra, Lidar, Merav, Litinsky, Irena, Levy, Yair, Carrillo Vazquez, Sandra Miriam, Rodriguez Reyna, Tatiana, Medrano Ramirez, Gabriel, Morales Torres, Jorge, Pacheco Tena, Cesar Francisco, Sanchez Ortiz, Adriana, Vonk, Madelon C., Stebbings, Simon, Solanki, Kamal, Steele, Richard, Ng, Kristine, Zubrzycka Sienkiewicz, Anna, Brzosko, Marek, Szepietowski, Jacek C., Hrycaj, Pawel, Da Silva, Ivone Fernandes Santo, Dos Santos, Lelita Da Conceiçao, Coelho, Paulo Jorge Clemente, Rios, Grissel, Chernykh, Tatiana, Grunina, Elena, Stanislav, Marina, Ally, Mahmood, Kalla, Asgar, Birlik, Ahmet Merih, Kovalenko, Volodymyr, Petrov, Andriy, Shevchuk, Sergiy, Stanislavchuk, Mykola, Anderson, Marina, Herrick, Ariane, Belch, Jill, Chung, Lorinda, Csuka, Mary Ellen, Frech, Tracy, Goldberg, Avram, Kahaleh, Bashar, Mayes, Maureen D., Rothfield, Naomi, Simms, Robert William, Spiera, Robert, Steen, Virgina, Varga, John, Sikes, David, Derk, Chris T., Kohen, Michael D., and Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428)

Abstract

Importance: Digital ulcers in patients with systemic sclerosis are associated with pain and poor quality of life. Endothelin-1 promotes vasculopathy in systemic sclerosis after macitentan, an endothelin-1 blocker. Objective: To evaluate the efficacy of macitentan in reducing the number of new digital ulcers in patients with systemic sclerosis. Design, Setting, And Participants: Two international, randomized, double-blind, placebo-controlled trials (DUAL-1, DUAL-2) were conducted between January 2012 and February 2014. Participants were patients with systemic sclerosis and active digital ulcers at baseline. Target enrollment for each study was 285 patients. Interventions: Patients were randomized (1:1:1) to receive oral doses of 3 mg of macitentan, 10 mg of macitentan, or placebo once daily and stratified according to number of digital ulcers at baseline (≤3 or >3). Main Outcomes and Measures: The primary outcome for each trialwas the cumulative number of new digital ulcers from baseline to week 16. Treatment effect was expressed as the ratio between treatment groups. Results: In DUAL-1, among 289 randomized patients (mean age 51.2 years; 85.8% women), 226 completed the study. The adjusted mean number of new digital ulcers per patient over 16 weeks was 0.94 in the 3-mg macitentan group (n = 95) and 1.08 in the 10-mg macitentan group (n = 97) compared with 0.85 in the placebo group (n = 97) (absolute difference, 0.09 [95% CI, -0.37 to 0.54] for 3mg of macitentan vs placebo and 0.23 [-0.27 to 0.72] for 10 mg of macitentan vs placebo). Among 265 patients randomized in DUAL-2 (mean age 49.6 years; 81.9% women), 216 completed the study. In DUAL-2, the adjusted mean number of new digital ulcers was 1.44 in the 3-mg macitentan group (n = 88) and 1.46 in the 10-mg macitentan group (n = 88) compared with 1.21 in the placebo group (n = 89) (absolute difference, 0.23 [95% CI, -0.35 to 0.82] for 3 mg of macitentan vs placebo and 0.25 [95% CI, -0.34 to 0.84] for 10mg of macitenta

Published
2016

25. Vasoactive Therapy in Systemic Sclerosis: Real-life Therapeutic Practice in More Than 3000 Patients

Author

Moinzadeh, Pia, Riemekasten, Gabriela, Siegert, Elise, Fierlbeck, Gerhard, Henes, Joerg, Blank, Norbert, Melchers, Inga, Müller-Ladner, Ulf, Frerix, Marc, Kreuter, Alexander, Tigges, Christian, Lahner, Nina, Susok, Laura, Guenther, Claudia, Zeidler, Gabriele, Pfeiffer, Christiane, Worm, Margitta, Karrer, Sigrid, Aberer, Elisabeth, Bretterklieber, Agnes, Genth, Ekkehard, Simon, Jan C., Distler, Joerg H.W., Hein, Ruediger, Schneider, Matthias, Seitz, Cornelia S., Herink, Claudia, Steinbrink, Kerstin, Sardy, Miklos, Varga, Rita, Mensing, Hartwig, Mensing, Christian, Lehmann, Percy, Neeck, Gunther, Fiehn, Christoph, Weber, Manfred, Goebeler, Matthias, Burkhardt, Harald, Buslau, Michael, Ahmadi-Simab, Keihan, Himsel, Andrea, Juche, Aaron, Koetter, Ina, Kuhn, Annegret, Sticherling, Michael, Hellmich, Martin, Kuhr, Kathrin, Krieg, Thomas M., Ehrchen, Jan, Sunderkoetter, Cord, Hunzelmann, Nicolas, Moinzadeh, Pia, Riemekasten, Gabriela, Siegert, Elise, Fierlbeck, Gerhard, Henes, Joerg, Blank, Norbert, Melchers, Inga, Müller-Ladner, Ulf, Frerix, Marc, Kreuter, Alexander, Tigges, Christian, Lahner, Nina, Susok, Laura, Guenther, Claudia, Zeidler, Gabriele, Pfeiffer, Christiane, Worm, Margitta, Karrer, Sigrid, Aberer, Elisabeth, Bretterklieber, Agnes, Genth, Ekkehard, Simon, Jan C., Distler, Joerg H.W., Hein, Ruediger, Schneider, Matthias, Seitz, Cornelia S., Herink, Claudia, Steinbrink, Kerstin, Sardy, Miklos, Varga, Rita, Mensing, Hartwig, Mensing, Christian, Lehmann, Percy, Neeck, Gunther, Fiehn, Christoph, Weber, Manfred, Goebeler, Matthias, Burkhardt, Harald, Buslau, Michael, Ahmadi-Simab, Keihan, Himsel, Andrea, Juche, Aaron, Koetter, Ina, Kuhn, Annegret, Sticherling, Michael, Hellmich, Martin, Kuhr, Kathrin, Krieg, Thomas M., Ehrchen, Jan, Sunderkoetter, Cord, and Hunzelmann, Nicolas

Published
2015

26. A role for Rac1 activity in malignant progression of sebaceous skin tumors

Author

Frances, D., Sharma, N., Pofahl, R., Maneck, M., Behrendt, K., Reuter, K., Krieg, Thomas M., Klein, C., Haase, I., Niemann, Carsten, Frances, D., Sharma, N., Pofahl, R., Maneck, M., Behrendt, K., Reuter, K., Krieg, Thomas M., Klein, C., Haase, I., and Niemann, Carsten

Published
2015

28. Migration of a Human Keratinocyte Cell Line (HACAT) to Interstitial Collagen Type I Is Mediated by the α2β1-Integrin Receptor.

Author

Scharffetter-Kochanek, Karin, Eberhard Klein, C., Heinen, Gudrun, Ivlauch, Cornelia, Schaefer, Thomas, Adelmann-Grill, Bernhard C., Goerz, Günter, Fusenig, Norbert E., Krieg, Thomas M., and Plewig, Gerd

Subjects
*KERATINOCYTES, *CELLS, *COLLAGEN, *INTEGRINS, *FIBRONECTINS, *EXTRACELLULAR matrix proteins
Abstract

The migratory response of the human keratinocyte cell line HaCaT to collagen type I and the molecular mechanism underlying collagen-mediated migration have been analyzed. The migratory response of HaCaT cells to collagen type I consisted of a dose-dependent migration to insoluble step gradients of substratum-bound collagen (haptotaxis) and to gradients of soluble collagen (chemotaxis). Checkerboard analysis demonstrated a minor chemokinetic component. Denatured collagen type I was less chemoattractive than the native triple-helical form. Pretreatment of cells with 25-250 μg/mI of synthetic peptides containing the fibronectin cell-recognition sequence RGD (Arg-Gly-Asp) resulted in a concentration-dependent inhibition of fibronectin-mediated chemotaxis, whereas chemotaxis to collagen was not affected. We then investigated the role of VLA/collagen-receptors for collagen type I - induced chemotaxis. Monoclonal antibody (MoAb) 5E8, which selectively blocks function of the α2 subunit of the VLA-2/collagen receptor, dose-dependently inhibited the chemotactic response of HaCaT cells to collagen. This effect was specific for collagen-mediated chemotaxis because the chemotactic response to fibronectin remained unaffected. In contrast, a function blocking MoAb directed to the α3 subunit of the coexpressed VLA-3 receptor, which is also capable of binding collagen, had no effect. However, function blocking MoAb directed to the β1-chain of integrins completely inhibited chemotaxis to collagen type I. Based on our results, we propose that the chemotactic migration of the human keratinocyte cell line (HaCaT) to collagen type I is specifically mediated by the RGD independent VLA-2/collagen receptor (α2β1) of the integrin family. [ABSTRACT FROM AUTHOR]

Published
1992
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