50 results on '"Kreyer S"'
Search Results
2. Pumpless extracorporeal CO2 removal restores normocapnia and is associated with less regional perfusion in experimental acute lung injury
- Author
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Kreyer, S., Muders, T., Luepschen, H., Kricklies, C., Linden, K., Tolba, R., Varelmann, D., Zinserling, J., Putensen, C., and Wrigge, H.
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- 2014
- Full Text
- View/download PDF
3. Weight loss of respiratory muscles during mechanical ventilation
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Hering, R., Viehöfer, A., Berg, A., Kreyer, S., Zinserling, J., Wrigge, H., and Putensen, C.
- Published
- 2003
- Full Text
- View/download PDF
4. Stand-alone cosmic muon reconstruction before installation of the CMS silicon strip tracker
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Adam, W, Bergauer, T, Dragicevic, M, Friedl, M, Fruhwirth, R, Hansel, S, Hrubec, J, Krammer, M, Oberegger, M, Pernicka, M, Schmid, S, Giammanco, A, Boudoul, G, Saizu, MA, Siegrist, P, Wagner, SR, Spagnolo, P, Bagby, L, Schwering, G, Dirkes, G, Lae, CK, Shah, Y, Pierschel, G, Demaria, N, Castaldi, R, Bhat, PC, Burkett, K, Cihangir, S, Rolandi, G, Tenchini, R, Cerri, C, Gutsche, O, Hahn, KA, Steiner, S, Jensen, H, Albergo, S, Tessaro, M, Fahrer, M, Johnson, M, Luzhetskiy, N, Sparti, V, Mason, D, Preda, M, Olzem, J, Dumitrache, F, Delattre, M, Bruno, G, Chabanat, E, Ceccanti, M, Rudolph, M, Didierjean, F, Miao, T, Frey, M, Uhl, D, Petrucciani, G, Moccia, S, Luukka, PR, Benotto, F, Tropea, P, Noeding, C, Ronzhin, A, Skup, E, Spalding, WJ, Manolescu, F, Mills, C, Stoye, M, Spiegel, L, Farano, R, Villella, I, Manna, N, Devroede, O, Brianzi, M, Sutera, C, Tkaczyk, S, Sala, G, Yumiceva, F, Karaevski, S, Troska, J, Zatserklyaniy, A, Wilke, L, Sung, K, Esser, H, Chabert, EC, Tolaini, S, Dietch, J, Anttila, E, Betchart, B, Wingham, M, Van Hove, P, Karpinski, W, Demina, R, Gotra, Y, Korjenevski, S, Leonardo, N, Bisello, D, Miner, D, Butt, S, Orbaker, D, Tavernier, S, Wittmer, B, Flugge, G, Furgeri, A, Cucoanes, AS, Garberson, J, Christofek, L, Ljuslin, C, Hooper, R, Civinini, C, De Mattia, M, Ageron, M, Tricomi, A, Tsirou, A, Migliore, E, Gregoire, G, Landsberg, G, Nguyen, D, Crook, A, Mannelli, M, Abbas, M, Narain, M, Lowette, S, Speer, T, Boccali, T, Venturi, A, Giubilato, P, Tsang, KV, CMS Collaboration, Dell'Orso, R, Keutgen, T, Covarelli, R, Vander Donckt, M, Tomalin, I, Wlochal, M, Hartmann, F, Romero, A, Chierici, R, Creanza, D, Kcira, D, Loreti, M, Fontaine, JC, Lemaitre, V, Steinbruck, G, Heyninck, J, Hale, D, Michotte, D, Militaru, O, Piotrzkowski, K, Quertermont, L, Kraan, A, Moulik, T, Roberfroid, V, Vasey, F, Thomas, M, Balestri, G, Kukulies, C, Giusti, S, Dobur, D, Rouby, X, Giorgi, MA, Teyssier, D, Incandela, H, Daubie, E, Rebassoo, F, Contardo, D, Giudice, N, Heier, S, Masetti, L, Anghel, IM, Buhmann, P, Della Negra, R, Chiorboli, M, De Wolf, EA, Dupasquier, T, Gelin, G, Giraud, N, Zorba, O, Verdini, PG, Guillot, G, Cole, JE, Estre, N, Meschini, M, Ciulli, V, Charaf, O, Adler, V, Bazterra, VE, Haroutunian, R, Goitom, I, Lumb, N, Hammad, GH, Vos, M, Dutta, S, Incandela, J, Regenfus, C, Gillissen, C, Perries, S, Schirra, F, De Callatay, B, Hobson, PR, Rommerskirchen, T, Trocme, B, Vanzetto, S, Borgia, MA, Marchioro, A, Zaccarelli, L, Agram, JL, Blaes, R, Ahmed, I, Hermanns, T, Calzolari, F, Jaditz, S, Paoletti, S, Mattiazzo, S, Robmann, P, Hoffmann, KH, Dewulf, JP, Waltenberger, W, Avanzini, C, Silvestris, L, Heydhausen, D, Khomenkov, V, Gerber, CE, Jahn, D, Kaussen, G, Linn, A, Perchalla, L, Buchmuller, O, Michal, S, Poettgens, M, Kalavase, P, Delmeire, E, Potenza, R, Breuker, H, Akhtar, I, Pooth, O, Foa, L, Stahl, A, Khalatian, S, Zoeller, MH, Tran, NV, Kaminski, J, Nigro, M, Reid, ID, Czellar, S, Cerati, GB, Ledermann, B, Bosi, F, Hosselet, J, Cardaci, M, Liamsuwan, T, Muller, S, Mersi, S, Muller, T, Richman, J, Schilling, FP, Lomtadze, T, Mariani, F, Maazouzi, C, Klein, K, Engstrom, P, Simonis, HJ, Steck, P, Anagnostou, G, Albert, E, Shabalina, E, Lamb, J, D'Alessandro, R, Zhukov, V, Cariola, P, Beissel, F, Nguyen, H, De Robertis, G, Ferorelli, R, Alagoz, E, Teodorescu, L, D'Hondt, J, Beaumont, W, Fiore, L, Maes, J, Focardi, E, Baringer, P, Lungu, GA, Basti, A, Mc Guinness, C, Paccagnella, A, Strub, R, Berst, JD, Mirabito, L, Lariccia, P, Frosali, S, Harkonen, J, Genta, C, Hashemi, M, Landi, G, Lenzi, P, Coughlan, JA, De Boer, W, Macchiolo, A, Bean, A, Stark, R, Church, I, Schmidt, A, Magini, N, Ronga, F, Parrini, G, Karimaki, V, Scarlini, E, Baulieu, G, Pantano, D, Vander Velde, C, Widl, E, Sarkar, S, Pozzobon, N, Castello, R, de Langhe, E, Goerlach, U, Tosi, M, Bilei, GM, Hanson, G, Checcucci, B, Fano, L, Cattai, A, Edera, LM, My, S, Noto, F, Butz, E, Servoli, L, Clerbaux, B, Costa, S, Jeng, GY, Kostesmaa, J, Florins, B, Martinelli, G, Ambroglini, F, Babucci, E, Sguazzoni, G, Robinson, R, Benedetti, D, Biasini, M, Kreyer, S, Ostapchuk, A, Graehling, P, Caponeri, B, Raupach, F, Moggi, A, Kuronen, A, Delaere, C, Muffat-Joly, J, Martin, C, Benucci, L, Tempesta, P, Liu, H, Gennai, S, Palla, F, Flucke, G, De Lentdecker, G, Juillot, P, Palmonari, F, Petragnani, G, Rubinstein, N, Profeti, A, Lampen, T, Drouhin, F, Ribnik, J, Nikolic, M, Raffaelli, F, Van Mulders, P, Rizzi, D, Hamdorf, R, Sanguinetti, G, Bocci, A, Feld, L, Brom, JM, De Weirdt, S, Cazzola, U, Amsler, C, Gross, L, De Filippis, N, Fiori, F, Linari, S, Massa, M, Messineo, A, Gay, APR, Bainbridge, R, Berretta, L, Cecchi, R, Azzi, P, Segneri, G, Olivetto, C, Bracci, F, Hauk, J, Bock, E, Tonelli, G, Azzurri, P, Magazzu, G, Tuominen, E, Vanlaer, P, Bernardini, J, Chen, J, De Palma, M, Borrello, L, Tuve, C, Eppard, M, Klanner, R, Taghavi, S, Pasztor, G, Maenpaa, T, Onnela, A, Mantovani, G, Sigaud, C, Gateau, M, Bacchetta, N, Brauer, R, Maggi, G, Gill, K, Giolo-Nicollerat, AS, Harris, P, Grabit, R, Pein, U, Everaerts, P, Gritsan, AV, Honma, A, Sprenger, D, Huhtinen, M, Candelori, A, Kloukinas, K, Paillard, C, Guardone, N, Zito, G, Pal, I, Kyre, S, Giordano, D, Postolache, V, Pernot, JF, Petagna, P, Petit, P, Piccut, C, Wastiels, C, Simms, L, Abbaneo, D, Sentenac, D, Pioppi, M, Selvaggi, G, Costa, M, Bouhali, O, Broccolo, B, Mozer, M, Goorens, R, Postema, H, Van Mechelen, P, Steininger, H, Ranieri, R, Linden, T, Santocchia, A, Ricci, D, Giassi, A, Cripps, N, Dorigo, T, Sanhueza, S, Blum, P, Satpathy, A, Ligabue, F, D'Alfonso, M, Fulcher, J, Serban, AT, Galanti, M, Bagliesi, G, Hall, G, Noy, M, Pesaresi, M, Kaminskiy, A, Bonnevaux, A, Tuominiemi, J, Radicci, V, Maletta, F, Raymond, DM, Slav, A, Sharp, P, Van Lancker, L, Marcantonini, M, Stringer, R, Hinchey, C, Spiga, D, Rizzi, A, Mangano, B, Affolder, K, Affolder, T, Allen, A, Weber, M, Rochet, J, Kortesmaa, J, Barge, D, Bianucci, S, Chiochia, V, Lounis, A, Mammini, P, Schael, S, Pandoulas, D, Burke, S, Ernenwein, JP, Callahan, D, Schleper, P, Yang, Z, Campagnari, C, Bloch, C, Staszak, D, Marage, P, Nahn, S, Reznikov, S, Syed, A, Zerev, E, Stoner, J, Kottelat, LJ, Elgammal, S, Wickens, J, Stuart, D, Swain, S, Vlimant, JR, Soldani, A, Dierlamm, A, White, D, Kartashov, D, Ulmer, KA, Bonnet, JL, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), informatique, Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Groupe de Recherche en Physique des Hautes Energies (GRPHE), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), European Organization for Nuclear Research (CERN), CMS, Adam, W., Bergauer, T., Dragicevic, M., Friedl, M., Fruehwirth, R., Haensel, S., Hrubec, J., Krammer, M., Oberegger, M., Pernicka, M., Schmid, S., Stark, R., Steininger, H., Uhl, D., Waltenberger, W., Widl, E., Van Mechelen, P., Cardaci, M., Beaumont, W., de Langhe, E., de Wolf, E. A., Delmeire, E., Hashemi, M., Bouhali, O., Charaf, O., Clerbaux, B., Dewulf, J. P., Elgammal, S., Hammad, G., de Lentdecker, G., Marage, P., Vander Velde, C., Vanlaer, P., Wickens, J., Adler, V., Devroede, O., De Weirdt, S., D'Hondt, J., Goorens, R., Heyninck, J., Maes, J., Mozer, M., Tavernier, S., Van Lancker, L., Van Mulders, P., Villella, I., Wastiels, C., Bonnet, J. L., Bruno, G., De Callatay, B., Florins, B., Giammanco, A., Gregoire, G., Keutgen, T. h., Kcira, D., Lemaitre, V., Michotte, D., Militaru, O., Piotrzkowski, K., Quertermont, L., Roberfroid, V., Rouby, X., Teyssier, D., Daubie, E., Anttila, E., Czellar, S., Engstroem, P., Harkonen, J., Karimaki, V., Kostesmaa, J., Kuronen, A., Lampen, T., Linden, T., Luukka, P. R., Maenpaa, T., Michal, S., Tuominen, E., Tuominiemi, J., Ageron, M., Baulieu, G., Bonnevaux, A., Boudoul, G., Chabanat, E., Chabert, E., Chierici, R., Contardo, D., Della Negra, R., Dupasquier, T., Gelin, G., Giraud, N., Guillot, G., Estre, N., Haroutunian, R., Lumb, N., Perries, S., Schirra, F., Trocme, B., Vanzetto, S., Agram, J. L., Blaes, R., Drouhin, F., Ernenwein, J. P., Fontaine, J. C., Berst, J. D., Brom, J. M., Didierjean, F., Goerlach, U., Graehling, P., Gross, L., Hosselet, J., Juillot, P., Lounis, A., Maazouzi, C., Olivetto, C., Strub, R., Van Hove, P., Anagnostou, G., Brauer, R., Esser, H., Feld, L., Karpinski, W., Klein, K., Kukulies, C., Olzem, J., Ostapchuk, A., Pandoulas, D., Pierschel, G., Raupach, F., Schael, S., Schwering, G., Sprenger, D., Thomas, M., Weber, M., Wittmer, B., Wlochal, M., Beissel, F., Bock, E., Flugge, G., Gillissen, C., Hermanns, T., Heydhausen, D., Jahn, D., Kaussen, G., Linn, A., Perchalla, L., Poettgens, M., Pooth, O., Stahl, A., Zoeller, M. H., Buhmann, P., Butz, E., Flucke, G., Hamdorf, R., Hauk, J., Klanner, R., Pein, U., Schleper, P., Steinbrueck, G., Bluem, P., De Boer, W., Dierlamm, A., Dirkes, G., Fahrer, M., Frey, M., Furgeri, A., Hartmann, F., Heier, S., Hoffmann, K. H., Kaminski, J., Ledermann, B., Liamsuwan, T., Mueller, S., Mueller, T. h., Schilling, F. P., Simonis, H. J., Steck, P., Zhukov, V., Cariola, P., De Robertis, G., Ferorelli, R., Fiore, L., Preda, M., Sala, G., Silvestris, L., Tempesta, P., Zito, G., Creanza, D., De Filippis, N., De Palma, M., Giordano, D., Maggi, G., Manna, N., My, S., Selvaggi, G., Albergo, S., Chiorboli, M., Costa, S., Galanti, M., Giudice, N., Guardone, N., Noto, F., Potenza, R., Saizu, M. A., Sparti, V., Sutera, C., Tricomi, A., Tuve, C., Brianzi, M., Civinini, C., Maletta, F., Manolescu, F., Meschini, M., Paoletti, S., Sguazzoni, G., Broccolo, B., Ciulli, V., D'Alessandro, R., Focardi, E., Frosali, S., Genta, C., Landi, G., Lenzi, P., Macchiolo, A., Magini, N., Parrini, G., Scarlini, E., Cerati, G., Azzi, P., Bacchetta, N., Candelori, A., Dorigo, T., Kaminsky, A., Karaevski, S., Khomenkov, V., Reznikov, S., Tessaro, M., Bisello, D., De Mattia, M., Giubilato, P., Loreti, M., Mattiazzo, S., Nigro, M., Paccagnella, A., Pantano, D., Pozzobon, N., Tosi, M., Bilei, G. M., Checcucci, B., Fano, L., Servoli, L., Ambroglini, F., Babucci, E., Benedetti, D., Biasini, M., Caponeri, B., Covarelli, R., Giorgi, M., Lariccia, P., Mantovani, G., Marcantonini, M., Postolache, V., Santocchia, A., Spiga, D., Bagliesi, G., Balestri, G., Berretta, L., Bianucci, S., Boccali, T., Bosi, F., Bracci, F., Castaldi, R., Ceccanti, M., Cecchi, R., Cerri, C., Cucoanes, A. S., Dell'Orso, R., Dobur, D., Dutta, S., Giassi, A., Giusti, S., Kartashov, D., Kraan, A., Lomtadze, T., Lungu, G. A., Magazzu, G., Mammini, P., Mariani, F., Martinelli, G., Moggi, A., Palla, F., Palmonari, F., Petragnani, G., Profeti, A., Raffaelli, F., Rizzi, D., Sanguinetti, G., Sarkar, S., Sentenac, D., Serban, A. T., Slav, A., Soldani, A., Spagnolo, P., Tenchini, R., Tolaini, S., Venturi, A., Verdini, P. G., Vos, M., Zaccarelli, L., Avanzini, C., Basti, A., Benucci, L., Bocci, A., Cazzola, U., Fiori, F., Linari, S., Massa, M., Messineo, A., Segneri, G., Tonelli, G., Azzurri, P., Bernardini, J., Borrello, L., Calzolari, Federico, Foa, L., Gennai, S., Ligabue, Franco, Petrucciani, G., Rizzi, A., Yang, Z., Benotto, F., Demaria, N., Dumitrache, F., Farano, R., Borgia, M. A., Castello, R., Costa, M., Migliore, E., Romero, A., Abbaneo, D., Abbas, M., Ahmed, I., Akhtar, I., Albert, E., Bloch, C., Breuker, H., Butt, S., Buchmuller, O., Cattai, A., Delaere, C., Delattre, M., Edera, L. M., Engstrom, P., Eppard, M., Gateau, M., Gill, K., Giolo Nicollerat, A. S., Grabit, R., Honma, A., Huhtinen, M., Kloukinas, K., Kortesmaa, J., Kottelat, L. J., Leonardo, N., Ljuslin, C., Mannelli, M., Masetti, L., Marchioro, A., Mersi, S., Mirabito, L., Muffat Joly, J., Onnela, A., Paillard, C., Pal, I., Pernot, J. F., Petagna, P., Petit, P., Piccut, C., Pioppi, M., Postema, H., Ranieri, R., Ricci, D., Rolandi, Luigi, Ronga, F., Sigaud, C., Syed, A., Siegrist, P., Tropea, P., Troska, J., Tsirou, A., Vander Donckt, M., Vasey, F., Alagoz, E., Amsler, C., Chiochia, V., Regenfus, C., Robmann, P., Rochet, J., Rommerskirchen, T., Schmidt, A., Steiner, S., Wilke, L., Church, I., Cole, J., Coughlan, J., Gay, A., Taghavi, S., Tomalin, I., Bainbridge, R., Cripps, N., Fulcher, J., Hall, G., Noy, M., Pesaresi, M., Radicci, V., Raymond, D. M., Sharp, P., Stoye, M., Wingham, M., Zorba, O., Goitom, I., Hobson, P. R., Reid, I., Teodorescu, L., Hanson, G., Jeng, G. Y., Liu, H., Pasztor, G., Satpathy, A., Stringer, R., Mangano, B., Affolder, K., Affolder, T., Allen, A., Barge, D., Burke, S., Callahan, D., Campagnari, C., Crook, A., D'Alfonso, M., Dietch, J., Garberson, J., Hale, D., Incandela, H., Incandela, J., Jaditz, S., Kalavase, P., Kreyer, S., Kyre, S., Lamb, J., Mc Guinness, C., Mills, C., Nguyen, H., Nikolic, M., Lowette, S., Rebassoo, F., Ribnik, J., Richman, J., Rubinstein, N., Sanhueza, S., Shah, Y., Simms, L., Staszak, D., Stoner, J., Stuart, D., Swain, S., Vlimant, J. R., White, D., Ulmer, K. A., Wagner, S. R., Bagby, L., Bhat, P. C., Burkett, K., Cihangir, S., Gutsche, O., Jensen, H., Johnson, M., Luzhetskiy, N., Mason, D., Miao, T., Moccia, S., Noeding, C., Ronzhin, A., Skup, E., Spalding, W. J., Spiegel, L., Tkaczyk, S., Yumiceva, F., Zatserklyaniy, A., Zerev, E., Anghel, I., Bazterra, V. E., Gerber, C. E., Khalatian, S., Shabalina, E., Baringer, P., Bean, A., Chen, J., Hinchey, C., Martin, C., Moulik, T., Robinson, R., Gritsan, A. V., Lae, C. K., Tran, N. V., Everaerts, P., Hahn, K. A., Harris, P., Nahn, S., Rudolph, M., Sung, K., Betchart, B., Demina, R., Gotra, Y., Korjenevski, S., Miner, D., Orbaker, D., Christofek, L., Hooper, R., Landsberg, G., Nguyen, D., Narain, M., Speer, T., Tsang, K. V., Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, CMS Tracker Collaboration, Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Physics - Instrumentation and Detectors ,Physics::Instrumentation and Detectors ,Astrophysics::High Energy Astrophysical Phenomena ,Silicon Detectors ,CMS ,TRACKER ,FOS: Physical sciences ,Cosmic ray ,01 natural sciences ,Nuclear physics ,cluster finding ,Pattern recognition ,0103 physical sciences ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Detectors and Experimental Techniques ,010306 general physics ,Instrumentation ,Image resolution ,Mathematical Physics ,Remote sensing ,Physics ,COSMIC cancer database ,Large Hadron Collider ,Muon ,010308 nuclear & particles physics ,Large detector systems for particle and astroparticle physics ,Particle tracking detectors (Solid-state detectors) ,Pattern recognition, cluster finding, calibration and fitting methods ,Track (disk drive) ,Settore FIS/01 - Fisica Sperimentale ,Detector ,Astrophysics::Instrumentation and Methods for Astrophysics ,Instrumentation and Detectors (physics.ins-det) ,calibration and fitting methods ,Scintillation counter - Abstract
The subsystems of the CMS silicon strip tracker were integrated and commissioned at the Tracker Integration Facility (TIF) in the period from November 2006 to July 2007. As part of the commissioning, large samples of cosmic ray data were recorded under various running conditions in the absence of a magnetic field. Cosmic rays detected by scintillation counters were used to trigger the readout of up to 15% of the final silicon strip detector, and over 4.7 million events were recorded. This document describes the cosmic track reconstruction and presents results on the performance of track and hit reconstruction as from dedicated analyses., Added missing LaTex command / no change in contents w.r.t. v1
- Published
- 2009
- Full Text
- View/download PDF
5. Alignment of the CMS silicon strip tracker during stand-alone commissioning
- Author
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Adam, W., Bergauer, T., Dragicevic, M., Friedl, M., Fruhwirth, R., Hansel, S., Hrubec, J., Krammer, M., Oberegger, M., Pernicka, M., Schmid, S., Stark, R., Steininger, H., Uhl, D., Waltenberger, W., Widl, E., Van Mechelen, P., Cardaci, M., Beaumont, W., de Langhe, E., de Wolf, E.A., Delmeire, E., Hashemi, M., Bouhali, O., Charaf, O., Clerbaux, B., Dewulf, J.-P., Elgammal, S., Hammad, G., de Lentdecker, G., Marage, P., Vander Velde, C., Vanlaer, P., Wickens, J., Adler, V., Devroede, O., De Weirdt, S., D'Hondt, J., Goorens, R., Heyninck, J., Maes, J., Mozer, Matthias Ulrich, Tavernier, S., Van Lancker, L., Van Mulders, P., Villella, I., Wastiels, C., Bonnet, J.-L., Bruno, G., De Callatay, B., Florins, B., Giammanco, A., Gregoire, G., Keutgen, Th., Kcira, D., Lemaitre, V., Michotte, D., Militaru, O., Piotrzkowski, K., Quertermont, L., Roberfroid, V., Rouby, X., Teyssier, D., daubie, E., Anttila, E., Czellar, S., Engstrom, P., Harkonen, J., Karimaki, V., Kostesmaa, J., Kuronen, A., Lampen, T., Linden, T., Luukka, P.-R., Maenaa, T., Michal, S., Tuominen, E., Tuominiemi, J., Ageron, M., Baulieu, G., Bonnevaux, A., Boudoul, G., Chabanat, E., Chabert, E., Chierici, R., Contardo, D., Della Negra, R., Dupasquier, T., Gelin, G., Giraud, N., Guillot, G., Estre, N., Haroutunian, R., Lumb, N., Perries, S., Schirra, F., Trocme, B., Vanzetto, S., Agram, J.-L., Blaes, R., Drouhin, F., Ernenwein, J.-P., Fontaine, J.-C., Berst, J.-D., Brom, J.-M., Didierjean, F., Goerlach, U., Graehling, P., Gross, L., Hosselet, J., Juillot, P., Lounis, A., Maazouzi, C., Olivetto, C., Strub, R., Van Hove, P., Anagnostou, G., Brauer, R., Esser, H., Feld, L., Karpinski, W., Klein, K., Kukulies, C., Olzem, J., Ostapchuk, A., Pandoulas, D., Pierschel, G., Raupach, F., Schael, S., Schwering, G., Sprenger, D., Thomas, M., Weber, M., Wittmer, B., Wlochal, M., Beissel, F., Bock, E., Flugge, G., Gillissen, C., Hermanns, T., Heydhausen, D., Jahn, D., Kaussen, G., Linn, A., Perchalla, L., Poettgens, M., Pooth, O., Stahl, A., Zoeller, M.H., Buhmann, P., Butz, E., Flucke, G., Hamdorf, R., Hauk, J., Klanner, R., Pein, U., Schleper, P., Steinbruck, G., Blum, P., De Boer, W., Dierlamm, A., Dirkes, G., Fahrer, M., Frey, M., Furgeri, A., Hartmann, F., Heier, S., Hoffmann, K.-H., Kaminski, J., Ledermann, B., Liamsuwan, T., Muller, S., Muller, Th., Schilling, F.-P., Simonis, H.-J., Steck, P., Zhukov, V., Cariola, P., De Robertis, G., Ferorelli, R., Fiore, L., Preda, M., Sala, G., Silvestris, L., Tempesta, P., Zito, G., Creanza, D., De Filippis, N., De Palma, M., Giordano, D., Maggi, G., Manna, N., My, S., Selvaggi, G., Albergo, S., Chiorboli, M., Costa, S., Galanti, M., Giudice, N., Guardone, N., Noto, F., Potenza, R., Saizu, M.A., Sparti, V., Sutera, C., Tricomi, A., Tuve, C., Brianzi, M., Civinini, C., Maletta, F., Manolescu, F., Meschini, M., Paoletti, S., Sguazzoni, G., Broccolo, B., Ciulli, V., D'Alessandro, R., Focardi, E., Frosali, S., Genta, C., Landi, G., Lenzi, P., Macchiolo, A., Magini, N., Parrini, G., Scarlini, E., Cerati, G., Azzi, P., Bacchetta, N., Candelori, A., Dorigo, T., Kaminsky, A., Karaevski, S., Khomenkov, V., Reznikov, S., Tessaro, M., Bisello, D., De Mattia, M., Giubilato, P., Loreti, M., Mattiazzo, S., Nigro, M., Paccagnella, A., Pantano, D., Pozzobon, N., Tosi, M., Bilei, G.M., Checcucci, B., Fano, L., Servoli, L., Ambroglini, F., Babucci, E., Benedetti, D., Biasini, M., Caponeri, B., Covarelli, R., Giorgi, M., Lariccia, P., Mantovani, G., Marcantonini, M., Postolache, V., Santocchia, A., Spiga, D., Bagliesi, G., Balestri, G., Berretta, L., Bianucci, S., Boccali, T., Bosi, F., Bracci, F., Castaldi, R., Ceccanti, M., Cecchi, R., Cerri, C., Cucoanes, A.S., Dell'Orso, R., Dobur, D., Dutta, S., Giassi, A., Giusti, S., Kartashov, D., Kraan, A., Lomtadze, T., Lungu, G.A., Magazzu, G., Mammini, P., Mariani, F., Martinelli, G., Moggi, A., Palla, F., Palmonari, F., Petragnani, G., Profeti, A., Raffaelli, F., Rizzi, D., Sanguinetti, G., Sarkar, S., Sentenac, D., Serban, A.T., Slav, A., Soldani, A., Spagnolo, P., Tenchini, R., Tolaini, S., Venturi, A., Verdini, P.G., Vos, M., Zaccarelli, L., Avanzini, C., Basti, A., Benucci, L., Bocci, A., Cazzola, U., Fiori, F., Linari, S., Massa, M., Messineo, A., Segneri, G., Tonelli, G., Azzurri, P., Bernardini, J., Borrello, L., Calzolari, F., Foa, L., Gennai, S., Ligabue, F., Petrucciani, G., Rizzi, A., Yang, Z., Benotto, F., Demaria, N., Dumitrache, F., Farano, R., Borgia, M.A., Castello, R., Costa, M., Migliore, E., Romero, A., Abbaneo, D., Abbas, M., Ahmed, I., Akhtar, I., Albert, E., Bloch, C., Breuker, H., Butt, S., Buchmuller, O., Cattai, A., Delaere, C., Delattre, M., Edera, L.M., Eppard, M., Gateau, M., Gill, K., Giolo-Nicollerat, A.-S., Grabit, R., Honma, A., Huhtinen, M., Kloukinas, K., Kortesmaa, J., Kottelat, L.J., Leonardo, N., Ljuslin, C., Mannelli, M., Masetti, L., Marchioro, A., Mersi, S., Mirabito, L., Muffat-Joly, J., Onnela, A., Paillard, C., Pal, I., Pernot, J.F., Petagna, P., Petit, P., Piccut, C., Pioppi, M., Postema, H., Ranieri, R., Ricci, D., Rolandi, G., Ronga, F., Sigaud, C., Syed, A., Siegrist, P., Tropea, P., Troska, J., Tsirou, A., Vander Donckt, M., Vasey, F., Alagoz, E., Amsler, Claude, Chiochia, V., Regenfus, Christian, Robmann, P., Rochet, J., Rommerskirchen, T., Schmidt, A., Steiner, S., Wilke, L., Church, I., Cole, J., Coughlan, J., Gay, A., Taghavi, S., Tomalin, I., Bainbridge, R., Cripps, N., Fulcher, J., Hall, G., Noy, M., Pesaresi, M., Radicci, V., Raymond, D.M., Sharp, P., Stoye, M., Wingham, M., Zorba, O., Goitom, I., Hobson, P.R., Reid, I., Teodorescu, L., Hanson, G., Jeng, G.-Y., Liu, H., Pasztor, G., Satpathy, A., Stringer, R., Mangano, B., Affolder, K., Affolder, T., Allen, A., Barge, D., Burke, S., Callahan, D., Campagnari, C., Crook, A., D'Alfonso, M., Dietch, J., Garberson, Jeffrey Ford, Hale, D., Incandela, H., Incandela, J., Jaditz, S., Kalavase, P., Kreyer, S., Kyre, S., Lamb, J., Mc Guinnessr, C., Mills, C., Nguyen, H., Nikolic, M., Lowette, S., Rebassoo, F., Ribnik, J., Richman, J., Rubinstein, N., Sanhueza, S., Shah, Y., Simms, L., Staszak, D., Stoner, J., Stuart, D., Swain, S., Vlimant, J.-R., White, D., Ulmer, K.A., Wagner, S.R., Bagby, L., Bhat, P.C., Burkett, K., Cihangir, S., Gutsche, O., Jensen, H., Johnson, M., Luzhetskiy, N., Mason, D., Miao, T., Moccia, S., Noeding, C., Ronzhin, A., Skup, E., Spalding, W.J., Spiegel, L., Tkaczyk, S., Yumiceva, F., Zatserklyaniy, A., Zerev, E., Anghel, I., Bazterra, V.E., Gerber, C.E., Khalatian, S., Shabalina, E., Baringer, Philip S., Bean, A., Chen, J., Hinchey, C., Martin, C., Moulik, T., Robinson, R., Gritsan, A.V., Lae, C.K., Tran, N.V., Everaerts, P., Hahn, K.A., Harris, P., Nahn, S., Rudolph, M., Sung, K., Betchart, B., Demina, R., Gotra, Y., Korjenevski, S., Miner, D., Orbaker, D., Christofek, L., Hooper, R., Landsberg, G., Nguyen, D., Narain, M., Speer, T., Tsang, K.V., Adam, W., Bergauer, T., Dragicevic, M., Friedl, M., Fruehwirth, R., Haensel, S., Hrubec, J., Krammer, M., Oberegger, M., Pernicka, M., Schmid, S., Stark, R., Steininger, H., Uhl, D., Waltenberger, W., Widl, E., Van Mechelen, P., Cardaci, M., Beaumont, W., de Langhe, E., de Wolf, E. A., Delmeire, E., Hashemi, M., Bouhali, O., Charaf, O., Clerbaux, B., Dewulf, J. P., Elgammal, S., Hammad, G., de Lentdecker, G., Marage, P., Velde C., Vander, Vanlaer, P., Wickens, J., Adler, V., Devroede, O., De Weirdt, S., D'Hondt, J., Goorens, R., Heyninck, J., Maes, J., Mozer, M., Tavernier, S., Van Lancker, L., Van Mulders, P., Villella, I., Wastiels, C., Bonnet, J. L., Bruno, G., De Callatay, B., Florins, B., Giammanco, A., Gregoire, G., Keutgen, T. h., Kcira, D., Lemaitre, V., Michotte, D., Militaru, O., Piotrzkowski, K., Quertermont, L., Roberfroid, V., Rouby, X., Teyssier, D., Daubie, E., Anttila, E., Czellar, S., Engstrom, P., Harkonen, J., Karimaki, V., Kostesmaa, J., Kuronen, A., Lampen, T., Linden, T., Luukka, P. R., Maenaa, T., Michal, S., Tuominen, E., Tuominiemi, J., Ageron, M., Baulieu, G., Bonnevaux, A., Boudoul, G., Chabanat, E., Chabert, E., Chierici, R., Contardo, D., Della Negra, R., Dupasquier, T., Gelin, G., Giraud, N., Guillot, G., Estre, N., Haroutunian, R., Lumb, N., Perries, S., Schirra, F., Trocme, B., Vanzetto, S., Agram, J. L., Blaes, R., Drouhin, F., Ernenwein, J. P., Fontaine, J. C., Berst, J. D., Brom, J. M., Didierjean, F., Goerlach, U., Graehling, P., Gross, L., Hosselet, J., Juillot, P., Lounis, A., Maazouzi, C., Olivetto, C., Strub, R., Van Hove, P., Anagnostou, G., Brauer, R., Esser, H., Feld, L., Karpinski, W., Klein, K., Kukulies, C., Olzem, J., Ostapchuk, A., Pandoulas, D., Pierschel, G., Raupach, F., Schael, S., Schwering, G., Sprenger, D., Thomas, M., Weber, M., Wittmer, B., Wlochal, M., Beissel, F., Bock, E., Flugge, G., Gillissen, C., Hermanns, T., Heydhausen, D., Jahn, D., Kaussen, G., Linn, A., Perchalla, L., Poettgens, M., Pooth, O., Stahl, A., Zoeller, M. H., Buhmann, P., Butz, E., Flucke, G., Hamdorf, R., Hauk, J., Klanner, R., Pein, U., Schleper, P., Steinbrueck, G., Bluem, P., De Boer, W., Dierlamm, A., Dirkes, G., Fahrer, M., Frey, M., Furgeri, A., Hartmann, F., Heier, S., Hoffmann, K. H., Kaminski, J., Ledermann, B., Liamsuwan, T., Mueller, S., Mueller, T. h., Schilling, F. P., Simonis, H. J., Steck, P., Zhukov, V., Cariola, P., De Robertis, G., Ferorelli, R., Fiore, L., Preda, M., Sala, G., Silvestris, L., Tempesta, P., Zito, G., Creanza, D., De Filippis, N., De Palma, M., Giordano, D., Maggi, G., Manna, N., My, S., Selvaggi, G., Albergo, S., Chiorboli, M., Costa, S., Galanti, M., Giudice, N., Guardone, N., Noto, F., Potenza, R., Saizu, M. A., Sparti, V., Sutera, C., Tricomi, A., Tuve, C., Brianzi, M., Civinini, C., Maletta, F., Manolescu, F., Meschini, M., Paoletti, S., Sguazzoni, G., Broccolo, B., Ciulli, V., Focardi, R. D. '. A. l. e. s. s. a. n. d. r. o. E., Frosali, S., Genta, C., Landi, G., Lenzi, P., Macchiolo, A., Magini, N., Parrini, G., Scarlini, E., Cerati, G., Azzi, P., Bacchetta, N., Candelori, A., Dorigo, T., Kaminsky, A., Karaevski, S., Khomenkov, V., Reznikov, S., Tessaro, M., Bisello, D., De Mattia, M., Giubilato, P., Loreti, M., Mattiazzo, S., Nigro, M., Paccagnella, A., Pantano, D., Pozzobon, N., Tosi, M., Bilei, G. M., Checcucci, B., Fano, L., Servoli, L., Ambroglini, F., Babucci, E., Benedetti, D., Biasini, M., Caponeri, B., Covarelli, R., Giorgi, M., Lariccia, P., Mantovani, G., Marcantonini, M., Postolache, V., Santocchia, A., Spiga, D., Bagliesi, G., Balestri, G., Berretta, L., Bianucci, S., Boccali, T., Bosi, F., Bracci, F., Castaldi, R., Ceccanti, M., Cecchi, R., Cerri, C., Cucoanes, A. S., Dell'Orso, R., Dobur, D., Dutta, S., Giassi, A., Giusti, S., Kartashov, D., Kraan, A., Lomtadze, T., Lungu, G. A., Magazzu, G., Mammini, P., Mariani, F., Martinelli, G., Moggi, A., Palla, F., Palmonari, F., Petragnani, G., Profeti, A., Raffaelli, F., Rizzi, D., Sanguinetti, G., Sarkar, S., Sentenac, D., Serban, A. T., Slav, A., Soldani, A., Spagnolo, P., Tenchini, R., Tolaini, S., Venturi, A., Verdini, P. G., Vos, M., Zaccarelli, L., Avanzini, C., Basti, A., Benucci, L., Bocci, A., Cazzola, U., Fiori, F., Linari, S., Massa, M., Messineo, A., Segneri, G., Tonelli, G., Azzurri, P., Bernardini, J., Borrello, L., Calzolari, Federico, Foa, L., Gennai, S., Ligabue, Franco, Petrucciani, G., Rizzi, A., Yang, Z., Benotto, F., Demaria, N., Dumitrache, F., Farano, R., Borgia, M. A., Castello, R., Costa, M., Migliore, E., Romero, A., Abbaneo, D., Abbas, M., Ahmed, I., Akhtar, I., Albert, E., Bloch, C., Breuker, H., Butt, S., Buchmuller, O., Cattai, A., Delaere, C., Delattre, M., Edera, L. M., Eppard, M., Gateau, M., Gill, K., Giolo Nicollerat, A. S., Grabit, R., Honma, A., Huhtinen, M., Kloukinas, K., Kortesmaa, J., Kottelat, L. J., Leonardo, N., Ljuslin, C., Mannelli, M., Masetti, L., Marchioro, A., Mersi, S., Mirabito, L., Muffat Joly, J., Onnela, A., Paillard, C., Pal, I., Pernot, J. F., Petagna, P., Petit, P., Piccut, C., Pioppi, M., Postema, H., Ranieri, R., Ricci, D., Rolandi, Luigi, Ronga, F., Sigaud, C., Syed, A., Siegrist, P., Tropea, P., Troska, J., Tsirou, A., Donckt M., Vander, Vasey, F., Alagoz, E., Amsler, C., Chiochia, V., Regenfus, C., Robmann, P., Rochet, J., Rommerskirchen, T., Schmidt, A., Steiner, S., Wilke, L., Church, I., Cole, J., Coughlan, J., Gay, A., Taghavi, S., Tomalin, I., Bainbridge, R., Cripps, N., Fulcher, J., Hall, G., Noy, M., Pesaresi, M., Radicci, V., Raymond, D. M., Sharp, P., Stoye, M., Wingham, M., Zorba, O., Goitom, I., Hobson, P. R., Reid, I., Teodorescu, L., Hanson, G., Jeng, G. Y., Liu, H., Pasztor, G., Satpathy, A., Stringer, R., Mangano, B., Affolder, K., Affolder, T., Allen, A., Barge, D., Burke, S., Callahan, D., Campagnari, C., Crook, A., D'Alfonso, M., Dietch, J., Garberson, J., Hale, D., Incandela, H., Incandela, J., Jaditz, S., Kalavase, P., Kreyer, S., Kyre, S., Lamb, J., Mc Guinness, C., Mills, C., Nguyen, H., Nikolic, M., Lowette, S., Rebassoo, F., Ribnik, J., Richman, J., Rubinstein, N., Sanhueza, S., Shah, Y., Simms, L., Staszak, D., Stoner, J., Stuart, D., Swain, S., Vlimant, J. R., White, D., Ulmer, K. A., Wagner, S. R., Bagby, L., Bhat, P. C., Burkett, K., Cihangir, S., Gutsche, O., Jensen, H., Johnson, M., Luzhetskiy, N., Mason, D., Miao, T., Moccia, S., Noeding, C., Ronzhin, A., Skup, E., Spalding, W. J., Spiegel, L., Tkaczyk, S., Yumiceva, F., Zatserklyaniy, A., Zerev, E., Anghel, I., Bazterra, V. E., Gerber, C. E., Khalatian, S., Shabalina, E., Baringer, P., Bean, A., Chen, J., Hinchey, C., Martin, C., Moulik, T., Robinson, R., Gritsan, A. V., Lae, C. K., Tran, N. V., Everaerts, P., Hahn, K. A., Harris, P., Nahn, S., Rudolph, M., Sung, K., Betchart, B., Demina, R., Gotra, Y., Korjenevski, S., Miner, D., Orbaker, D., Christofek, L., Hooper, R., Landsberg, G., Nguyen, D., Narain, M., Speer, T., Tsang, K. V., Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), informatique, Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Groupe de Recherches en Physique des Hautes Energies, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and CMS
- Subjects
Physics - Instrumentation and Detectors ,Silicon ,Computer science ,Tracker ,Barrel (horology) ,FOS: Physical sciences ,chemistry.chemical_element ,Residual ,01 natural sciences ,7. Clean energy ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Optics ,cluster finding ,law ,Particle tracking detectors ,Pattern recognition ,0103 physical sciences ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Detectors and Experimental Techniques ,Instrumentation ,Mathematical Physics ,COSMIC cancer database ,Large Hadron Collider ,Pattern recognition, cluster finding, calibration and fitting methods ,010308 nuclear & particles physics ,business.industry ,CMS ,Track (disk drive) ,Physics ,Settore FIS/01 - Fisica Sperimentale ,Ranging ,Instrumentation and Detectors (physics.ins-det) ,Silicon Detectors ,calibration and fitting methods ,Laser ,Analysis and statistical methods ,Particle tracking detectors (Solid-state detectors) ,chemistry ,TRACKER ,business - Abstract
The results of the CMS tracker alignment analysis are presented using the data from cosmic tracks, optical survey information, and the laser alignment system at the Tracker Integration Facility at CERN. During several months of operation in the spring and summer of 2007, about five million cosmic track events were collected with a partially active CMS Tracker. This allowed us to perform first alignment of the active silicon modules with the cosmic tracks using three different statistical approaches; validate the survey and laser alignment system performance; and test the stability of Tracker structures under various stresses and temperatures ranging from +15C to -15C. Comparison with simulation shows that the achieved alignment precision in the barrel part of the tracker leads to residual distributions similar to those obtained with a random misalignment of 50 (80) microns in the outer (inner) part of the barrel., Comment: 41 pages, 63 postscript figures, submitted to JINST
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- 2009
- Full Text
- View/download PDF
6. Modular extracorporeal life support: effects of ultrafiltrate recirculation on the performance of an extracorporeal carbon dioxide removal device
- Author
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Scaravilli, V, Kreyer, S, Linden, K, Belenkiy, S, Jordan, B, Pesenti, A, Zanella, A, Chung, K, Cannon, J, Cancio, L, Batchinsky, A, SCARAVILLI, VITTORIO, PESENTI, ANTONIO MARIA, ZANELLA, ALBERTO, Batchinsky, A., Scaravilli, V, Kreyer, S, Linden, K, Belenkiy, S, Jordan, B, Pesenti, A, Zanella, A, Chung, K, Cannon, J, Cancio, L, Batchinsky, A, SCARAVILLI, VITTORIO, PESENTI, ANTONIO MARIA, ZANELLA, ALBERTO, and Batchinsky, A.
- Abstract
The combination of extracorporeal carbon dioxide removal (ECCO2R) and hemofiltration is a possible therapeutic strategy for patients needing both lung and renal support. We tested the effects of the recirculation of ultrafiltrate on membrane lung (ML) CO2 removal (VCO2ML). Three conscious, spontaneously breathing sheep were connected to a commercially produced ECCO2R device (Hemolung; Alung Technologies, Pittsburgh, PA) with a blood flow of 250 ml/min and a gas flow of 10 L/min. A hemofilter (NxStage, NxStage Medical, Lawrence, MA) was interposed in series after the ML. Ultrafiltrate flow was generated and recirculated before the ML. We tested four ultrafiltrate flows (0, 50, 100, and 150 ml/min) for 25 min each, eight times per animal, resulting in 24 randomized test repetitions. We recorded VCO2ML, hemodynamics and ventilatory variables, and natural lung CO2 transfer (VCO2NL) and collected arterial and circuitry blood samples. VCO2ML was unchanged by application of ultrafiltrate recirculation (40.5 ± 4.0, 39.7 ± 4.2, 39.8 ± 4.2, and 39.2 ± 4.1 ml/min, respectively, at ultrafiltrate flow of 0, 50, 100, and 150 ml/min). Minute ventilation, respiratory rate, VCO2NL, and arterial blood analyses were not affected by ultrafiltrate recirculation. In the tested configuration, ultrafiltrate recirculation did not affect VCO2ML. This modular technology may provide a suitable platform for coupling CO2 removal with various forms of blood purification
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- 2014
7. Stand-alone cosmic muon reconstruction before installation of the CMS silicon strip tracker RID A-6508-2010 RID E-8846-2011 RID C-8364-2011
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Adam, W, Bergauer, T, Dragicevic, M, Friedl, M, Fruhwirth, R, Hansel, S, Hrubec, J, Krammer, M, Oberegger, M, Pernicka, M, Schmid, S, Stark, R, Steininger, H, Uhl, D, Waltenberger, W, Widl, E, Van Mechelen, P, Cardaci, M, Beaumont, W, de Langhe, E, de Wolf EA, Delmeire, E, Hashemi, M, Bouhali, O, Charaf, O, Clerbaux, B, Dewulf, Jp, Elgammal, S, Hammad, G, de Lentdecker, G, Marage, P, Vander Velde, C, Vanlaer, P, Wickens, J, Adler, V, Devroede, O, De Weirdt, S, D'Hondt, J, Goorens, R, Heyninck, J, Maes, J, Mozer, M, Tavernier, S, Van Lancker, L, Van Mulders, P, Villella, I, Wastiels, C, Bonnet, Jl, Bruno, G, De Callatay, B, Florins, B, Giammanco, A, Gregoire, G, Keutgen, T, Kcira, D, Lemaitre, V, Michotte, D, Militaru, O, Piotrzkowski, K, Quertermont, L, Roberfroid, V, Rouby, X, Teyssier, D, Daubie, E, Anttila, E, Czellar, S, Engstrom, P, Harkonen, J, Karimaki, V, Kostesmaa, J, Kuronen, A, Lampen, T, Linden, T, Luukka, Pr, Maenpaa, T, Michal, S, Tuominen, E, Tuominiemi, J, Ageron, M, 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Gennai, S, Ligabue, F, Petrucciani, G, Rizzi, Andrea, Yang, Z, Benotto, F, Demaria, N, Dumitrache, F, Farano, R, Borgia, Ma, Castello, R, Costa, M, Migliore, E, Romero, A, Abbaneo, D, Abbas, M, Ahmed, I, Akhtar, I, Albert, E, Bloch, C, Breuker, H, Butt, S, Buchmuller, O, Cattai, A, Delaere, C, Delattre, M, Edera, Lm, Eppard, M, Gateau, M, Gill, K, Giolo Nicollerat AS, Grabit, R, Honma, A, Huhtinen, M, Kloukinas, K, Kortesmaa, J, Kottelat, Lj, Leonardo, N, Ljuslin, C, Mannelli, M, Masetti, L, Marchioro, A, Mersi, S, Mirabito, L, Muffat Joly, J, Onnela, A, Paillard, C, Pal, I, Pernot, Jf, Petagna, P, Petit, P, Piccut, C, Pioppi, M, Postema, H, Ranieri, R, Ricci, D, Rolandi, G, Ronga, F, Sigaud, C, Syed, A, Siegrist, P, Tropea, P, Troska, J, Tsirou, A, Vander Donckt, M, Vasey, F, Alagoz, E, Amsler, C, Chiochia, V, Regenfus, C, Robmann, P, Rochet, J, Rommerskirchen, T, Schmidt, A, Steiner, S, Wilke, L, Church, I, Cole, J, Coughlan, J, Gay, A, Taghavi, S, Tomalin, I, Bainbridge, R, Cripps, N, Fulcher, J, Hall, G, Noy, M, Pesaresi, M, Radicci, V, Raymond, Dm, Sharp, P, Stoye, M, Wingham, M, Zorba, O, Goitom, I, Hobson, Pr, Reid, I, Teodorescu, L, Hanson, G, Jeng, Gy, Liu, H, Pasztor, G, Satpathy, A, Stringer, R, Mangano, B, Affolder, K, Affolder, T, Allen, A, Barge, D, Burke, S, Callahan, D, Campagnari, C, Crook, A, D'Alfonso, M, Dietch, J, Garberson, J, Hale, D, Incandela, H, Incandela, J, Jaditz, S, Kalavase, P, Kreyer, S, Kyre, S, Lamb, J, Mc Guinness, C, Mills, C, Nguyen, H, Nikolic, M, Lowette, S, Rebassoo, F, Ribnik, J, Richman, J, Rubinstein, N, Sanhueza, S, Shah, Y, Simms, L, Staszak, D, Stoner, J, Stuart, D, Swain, S, Vlimant, Jr, White, D, Ulmer, Ka, Wagner, Sr, Bagby, L, Bhat, Pc, Burkett, K, Cihangir, S, Gutsche, O, Jensen, H, Johnson, M, Luzhetskiy, N, Mason, D, Miao, T, Moccia, S, Noeding, C, Ronzhin, A, Skup, E, Spalding, Wj, Spiegel, L, Tkaczyk, S, Yumiceva, F, Zatserklyaniy, A, Zerev, E, Anghel, I, Bazterra, Ve, Gerber, Ce, Khalatian, S, Shabalina, E, 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A., Thomson, E., Tipton, P., Tiwari, V., Tkaczyk, S., Toback, D., Tokar, S., Tollefson, K., Tomura, T., Tonelli, D., Torre, S., Torretta, D., Tourneur, S., Trischuk, W., Tu, Y., Turini, N., Ukegawa, F., Uozumi, S., Vallecorsa, S., van Remortel, N., Varganov, A., Vataga, E., Vazquez, F., Velev, G., Vellidis, C., Veszpremi, V., Vidal, M., Vidal, R., Vila, I., Vilar, R., Vine, T., Vogel, M., Volobouev, I., Volpi, G., Wurthwein, F., Wagner, P., Wagner, R. G., Wagner, R. L., Wagner Kuhr, J., Wagner, W., Wakisaka, T., Wallny, R., Wang, S. M., Warburton, A., Waters, D., Weinberger, M., Iii, Wester W. C., Whitehouse, B., Whiteson, D., Wicklund, A. B., Wicklund, E., Williams, G., Williams, H. H., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, C., Wright, T., Wu, X., Wynne, S. M., Yagil, A., Yamamoto, K., Yamaoka, J., Yamashita, T., Yang, C., Yang, U. K., Yang, Y. C., Yao, W. M., Yeh, G. P., Yoh, J., Yorita, K., Yoshida, T., G. B., Yu, Yu, I., S. S., Yu, Yun, J. C., Zanello, L., Zanetti, A., Zaw, I., Zhang, X., Zheng, Y., and Zucchelli, S.
- Published
- 2009
8. Improved Measurement of B(+)->rho(+)rho(0) and Determination of the Quark-Mixing Phase Angle alpha RID C-5223-2009
- Author
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Aubert, B, Karyotakis, Y, Lees, Jp, Poireau, V, Prencipe, E, Prudent, X, Tisserand, V, Tico, Jg, Grauges, E, Lopez, L, Palano, A, Pappagallo, M, Eigen, G, Stugu, B, Sun, L, Battaglia, M, Brown, Dn, Kerth, Lt, Kolomensky, Yg, Lynch, G, Osipenkov, Il, Tackmann, K, Tanabe, T, Hawkes, Cm, Soni, N, Watson, At, Koch, H, Schroeder, T, Asgeirsson, Dj, Fulsom, Bg, Hearty, C, Mattison, Ts, Mckenna, Ja, Barrett, M, Khan, A, Randle Conde, A, Blinov, Ve, Bukin, Ad, Buzykaev, Ar, Druzhinin, Vp, Golubev, Vb, Onuchin, Ap, Serednyakov, Si, Skovpen, Yi, Solodov, Ep, Todyshev, Ky, Bondioli, M, Curry, S, Eschrich, I, Kirkby, D, Lankford, Aj, Lund, P, Mandelkern, M, Martin, Ec, Stoker, Dp, Abachi, S, Buchanan, C, Atmacan, H, Gary, Jw, Liu, F, Long, O, Vitug, Gm, Yasin, Z, Zhang, L, Sharma, V, Campagnari, C, Hong, Tm, Kovalskyi, D, Mazur, Ma, Richman, Jd, Beck, Tw, Eisner, Am, Heusch, Ca, Kroseberg, J, Lockman, Ws, Martinez, Aj, Schalk, T, Schumm, Ba, Seiden, A, Winstrom, Lo, Cheng, Ch, Doll, Da, Echenard, B, Fang, F, Hitlin, Dg, Narsky, I, Piatenko, T, Porter, Fc, Andreassen, R, Mancinelli, G, Meadows, Bt, Mishra, K, Sokoloff, Md, Bloom, Pc, Ford, Wt, Gaz, A, Hirschauer, Jf, Nagel, M, Nauenberg, U, Smith, Jg, Wagner, Sr, Ayad, R, Soffer, A, Toki, Wh, Wilson, Rj, Feltresi, E, Hauke, A, Jasper, H, Karbach, M, Merkel, J, Petzold, A, Spaan, B, Wacker, K, Kobel, Mj, Nogowski, R, Schubert, Kr, Schwierz, R, Volk, A, Bernard, D, Bonneaud, Gr, Latour, E, Verderi, M, Clark, Pj, Playfer, S, Watson, Je, Andreotti, M, Bettoni, D, Bozzi, C, Calabrese, R, Cecchi, A, Cibinetto, G, Franchini, P, Luppi, E, Negrini, M, Petrella, A, Piemontese, L, Santoro, V, Baldini Ferroli, R, Calcaterra, A, Sangro, R, Finocchiaro, G, Pacetti, S, Patteri, P, Peruzzi, Im, Piccolo, M, Rama, M, Zallo, A, Contri, R, Guido, E, Lo Vetere, M, Monge, Mr, Passaggio, S, Patrignani, C, Robutti, E, Tosi, S, Chaisanguanthum, Ks, Morii, M, Adametz, A, Marks, J, Schenk, S, Uwer, U, Bernlochner, Fu, Klose, V, Lacker, Hm, Bard, Dj, Dauncey, Pd, Tibbetts, M, Behera, Pk, Chai, X, Charles, Mj, Mallik, U, Cochran, J, Crawley, Hb, Dong, L, Meyer, Wt, Prell, S, Rosenberg, Ei, Rubin, Ae, Gao, Yy, Gritsan, Av, Guo, Zj, Arnaud, N, Bequilleux, J, D'Orazio, A, Davier, M, da Costa JF, Grosdidier, G, Le Diberder, F, Lepeltier, V, Lutz, Am, Pruvot, S, Roudeau, P, Schune, Mh, Serrano, J, Sordini, V, Stocchi, A, Wormser, G, Lange, Dj, Wright, Dm, Bingham, I, Burke, Jp, Chavez, Ca, Fry, Jr, Gabathuler, E, Gamet, R, Hutchcroft, De, Payne, Dj, Touramanis, C, Bevan, Aj, Clarke, Ck, Di Lodovico, F, Sacco, R, Sigamani, M, Cowan, G, Paramesvaran, S, Wren, Ac, Davis, Cl, Denig, Ag, Fritsch, M, Gradl, W, Hafner, A, Alwyn, Ke, Bailey, D, Barlow, Rj, Jackson, G, Lafferty, Gd, West, Tj, Yi, Ji, Anderson, J, Chen, C, Jawahery, A, Roberts, Da, Simi, G, Tuggle, Jm, Dallapiccola, C, Salvati, E, Saremi, S, Cowan, R, Dujmic, D, Fisher, Ph, Henderson, Sw, Sciolla, G, Spitznagel, M, Yamamoto, Rk, Zhao, M, Patel, Pm, Robertson, Sh, Schram, M, Lazzaro, A, Lombardo, V, Palombo, F, Stracka, S, Bauer, Jm, Cremaldi, L, Godang, R, Kroeger, R, Summers, Dj, Zhao, Hw, Simard, M, Taras, P, Nicholson, H, De Nardo, G, Lista, L, Monorchio, D, Onorato, G, Sciacca, C, Raven, G, Snoek, Hl, Jessop, Cp, Knoepfel, Kj, Losecco, Jm, Wang, Wf, Corwin, La, Honscheid, K, Kagan, H, Kass, R, Morris, Jp, Rahimi, Am, Regensburger, Jj, Sekula, Sj, Wong, Qk, Blount, Nl, Brau, J, Frey, R, Igonkina, O, Kolb, Ja, Lu, M, Rahmat, R, Sinev, Nb, Strom, D, Strube, J, Torrence, E, Castelli, G, Gagliardi, N, Margoni, M, Morandin, M, Posocco, M, Rotondo, M, Simonetto, F, Stroili, R, Voci, C, Sanchez, Pd, Ben Haim, E, Briand, H, Chauveau, J, Hamon, O, Leruste, P, Ocariz, J, Perez, A, Prendki, J, Sitt, S, Gladney, L, Biasini, M, Manoni, E, Angelini, Carlo, Batignani, Giovanni, Bettarini, Stefano, Calderini, Giovanni, Carpinelli, M, Cervelli, A, Forti, Francesco, Giorgi, Marcello, Lusiani, A, Marchiori, G, Morganti, M, Neri, N, Paoloni, Eugenio, Rizzo, Giuliana, Walsh, Jj, Pegna, Dl, Lu, C, Olsen, J, Smith, Ajs, Telnov, Av, Anulli, F, Baracchini, E, Cavoto, G, Faccini, R, Ferrarotto, F, Ferroni, F, Gaspero, M, Jackson, Pd, Li Gioi, L, Mazzoni, Ma, Morganti, S, Piredda, G, Renga, F, Voena, C, Ebert, M, Hartmann, T, Schroder, H, Waldi, R, Adye, T, Franek, B, Olaiya, Eo, Wilson, Ff, Emery, S, Esteve, L, de Monchenault GH, Kozanecki, W, Vasseur, G, Yeche, C, Zito, M, Chen, Xr, Liu, H, Park, W, Purohit, Mv, White, Rm, Wilson, Jr, Allen, Mt, Aston, D, Bartoldus, R, Benitez, Jf, Cenci, R, Coleman, Jp, Convery, Mr, Dingfelder, Jc, Dorfan, J, Dubois Felsmann GP, Dunwoodie, W, Field, Rc, Gabareen, Am, Graham, Mt, Grenier, P, Hast, C, Innes, Wr, Kaminski, J, Kelsey, Mh, Kim, H, Kim, P, Kocian, Ml, Leith, Dwgs, Li, S, Lindquist, B, Luitz, S, Luth, V, Lynch, Hl, Macfarlane, Db, Marsiske, H, Messner, R, Muller, Dr, Neal, H, Nelson, S, O'Grady, Cp, Ofte, I, Perl, M, Ratcliff, Bn, Roodman, A, Salnikov, Aa, Schindler, Rh, Schwiening, J, Snyder, A, Su, D, Sullivan, Mk, Suzuki, K, Swain, Sk, Thompson, Jm, Va'Vra, J, Wagner, Ap, Weaver, M, West, Ca, Wisniewski, Wj, Wittgen, M, Wright, Dh, Wulsin, Hw, Yarritu, Ak, Yi, K, Young, Cc, Ziegler, V, Burchat, Pr, Edwards, Aj, Miyashita, Ts, Ahmed, S, Alam, Ms, Ernst, Ja, Pan, B, Saeed, Ma, Zain, Sb, Spanier, Sm, Wogsland, Bj, Eckmann, R, Ritchie, Jl, Ruland, Am, Schilling, Cj, Schwitters, Rf, Drummond, Bw, Izen, Jm, Lou, Xc, Bianchi, F, Gamba, D, Pelliccioni, M, Bomben, M, Bosisio, L, Cartaro, C, Ricca, G, Lanceri, L, Vitale, L, Azzolini, V, Lopez March, N, Martinez Vidal, F, Milanes, Da, Oyanguren, A, Albert, J, Banerjee, S, Bhuyan, B, Choi, Hhf, Hamano, K, King, Gj, Kowalewski, R, Lewczuk, Mj, Nugent, Im, Roney, Jm, Sobie, Rj, Gershon, Tj, Harrison, Pf, Ilic, J, Latham, Te, Mohanty, Gb, Puccio, Emt, Band, Hr, Chen, X, Dasu, S, Flood, Kt, Pan, Y, Prepost, R, Vuosalo, Co, Wu SL Allen, A., Barge, D., Burke, S., Callahan, D., Campagnari, C., Crook, A., D'Alfonso, M., Dietch, J., Garberson, J., Hale, D., Incandela, H., Incandela, J., Jaditz, S., Kalavase, P., Kreyer, S., Kyre, S., Lamb, J., Mc Guinness, C., Mills, C., Nguyen, H., Nikolic, M., Lowette, S., Rebassoo, F., Ribnik, J., Richman, J., Rubinstein, N., Sanhueza, S., Shah, Y., Simms, L., Staszak, D., Stoner, J., Stuart, D., Swain, S., Vlimant, J. R., White, D., Ulmer, K. A., Wagner, S. R., Bagby, L., Bhat, P. C., Burkett, K., Cihangir, S., Gutsche, O., Jensen, H., Johnson, M., Luzhetskiy, N., Mason, D., Miao, T., Moccia, S., Noeding, C., Ronzhin, A., Skup, E., Spalding, W. J., Spiegel, L., Tkaczyk, S., Yumiceva, F., Zatserklyaniy, A., Zerev, E., Anghel, I., Bazterra, V. E., Gerber, C. E., Khalatian, S., Shabalina, E., Baringer, P., Bean, A., Chen, J., Hinchey, C., Martin, C., Moulik, T., Robinson, R., Gritsan, A. V., Lae, C. K., Tran, N. V., Everaerts, P., Hahn, K. A., Harris, P., Nahn, S., Rudolph, M., Sung, K., Betchart, B., Demina, R., Gotra, Y., Korjenevski, S., Miner, D., Orbaker, D., Christofek, L., Hooper, R., Landsberg, G., Nguyen, D., Narain, M., Speer, T., dal F, Tsang K. V., Panvini, Rs, Brown, Cm, Fortin, D, Back, Jj, Cheng, B, Datta, M, Eichenbaum, Am, Graham, M, Hollar, Jj, Johnson, Jr, Kutter, Pe, Li, H, Liu, R, Mihalyi, A, Tan, P, von Wimmersperg Toeller JH, Wu, J, Wu, Sl, Yu, Z, Greene, Mg, Neal, H., Aubert, B, Karyotakis, Y, Lees, Jp, Poireau, V, Prencipe, E, Prudent, X, Tisserand, V, Tico, Jg, Grauges, E, Lopez, L, Palano, A, Pappagallo, M, Eigen, G, Stugu, B, Sun, L, Battaglia, M, Brown, Dn, Kerth, Lt, Kolomensky, Yg, Lynch, G, Osipenkov, Il, Tackmann, K, Tanabe, T, Hawkes, Cm, Soni, N, Watson, At, Koch, H, Schroeder, T, Asgeirsson, Dj, Fulsom, Bg, Hearty, C, Mattison, T, Mckenna, Ja, Barrett, M, Khan, A, Randle Conde, A, Blinov, Ve, Bukin, Ad, Buzykaev, Ar, Druzhinin, Vp, Golubev, Vb, Onuchin, Ap, Serednyakov, Si, Skovpen, Yi, Solodov, Ep, Todyshev, Ky, Bondioli, M, Curry, S, Eschrich, I, Kirkby, D, Lankford, Aj, Lund, P, Mandelkern, M, Martin, Ec, Stoker, Dp, Abachi, S, Buchanan, C, Atmacan, H, Gary, Jw, Liu, F, Long, O, Vitug, Gm, Yasin, Z, Zhang, L, Sharma, V, Campagnari, C, Hong, Tm, Kovalskyi, D, Mazur, Ma, Richman, Jd, Beck, Tw, Eisner, Am, Heusch, Ca, Kroseberg, J, Lockman, W, Martinez, Aj, Schalk, T, Schumm, Ba, Seiden, A, Winstrom, Lo, Cheng, Ch, Doll, Da, Echenard, B, Fang, F, Hitlin, Dg, Narsky, I, Piatenko, T, Porter, Fc, Andreassen, R, Mancinelli, G, Meadows, Bt, Mishra, K, Sokoloff, Md, Bloom, Pc, Ford, Wt, Gaz, A, Hirschauer, Jf, Nagel, M, Nauenberg, U, Smith, Jg, Wagner, Sr, Ayad, R, Soffer, A, Toki, Wh, Wilson, Rj, Feltresi, E, Hauke, A, Jasper, H, Karbach, M, Merkel, J, Petzold, A, Spaan, B, Wacker, K, Kobel, Mj, Nogowski, R, Schubert, Kr, Schwierz, R, Volk, A, Bernard, D, Bonneaud, Gr, Latour, E, Verderi, M, Clark, Pj, Playfer, S, Watson, Je, Andreotti, M, Bettoni, D, Bozzi, C, Calabrese, R, Cecchi, A, Cibinetto, G, Franchini, P, Luppi, E, Negrini, M, Petrella, A, Piemontese, L, Santoro, V, Baldini Ferroli, R, Calcaterra, A, Sangro, R, Finocchiaro, G, Pacetti, S, Patteri, P, Peruzzi, Im, Piccolo, M, Rama, M, Zallo, A, Contri, R, Guido, E, Lo Vetere, M, Monge, Mr, Passaggio, S, Patrignani, C, Robutti, E, Tosi, S, Chaisanguanthum, K, Morii, M, Adametz, A, Marks, J, Schenk, S, Uwer, U, Bernlochner, Fu, Klose, V, Lacker, Hm, Bard, Dj, Dauncey, Pd, Tibbetts, M, Behera, Pk, Chai, X, Charles, Mj, Mallik, U, Cochran, J, Crawley, Hb, Dong, L, Meyer, Wt, Prell, S, Rosenberg, Ei, Rubin, Ae, Gao, Yy, Gritsan, Av, Guo, Zj, Arnaud, N, Bequilleux, J, D'Orazio, A, Davier, M, da Costa, Jf, Grosdidier, G, Le Diberder, F, Lepeltier, V, Lutz, Am, Pruvot, S, Roudeau, P, Schune, Mh, Serrano, J, Sordini, V, Stocchi, A, Wormser, G, Lange, Dj, Wright, Dm, Bingham, I, Burke, Jp, Chavez, Ca, Fry, Jr, Gabathuler, E, Gamet, R, Hutchcroft, De, Payne, Dj, Touramanis, C, Bevan, Aj, Clarke, Ck, Di Lodovico, F, Sacco, R, Sigamani, M, Cowan, G, Paramesvaran, S, Wren, Ac, Davis, Cl, Denig, Ag, Fritsch, M, Gradl, W, Hafner, A, Alwyn, Ke, Bailey, D, Barlow, Rj, Jackson, G, Lafferty, Gd, West, Tj, Yi, Ji, Anderson, J, Chen, C, Jawahery, A, Roberts, Da, Simi, G, Tuggle, Jm, Dallapiccola, C, Salvati, E, Saremi, S, Cowan, R, Dujmic, D, Fisher, Ph, Henderson, Sw, Sciolla, G, Spitznagel, M, Yamamoto, Rk, Zhao, M, Patel, Pm, Robertson, Sh, Schram, M, Lazzaro, A, Lombardo, V, Palombo, F, Stracka, S, Bauer, Jm, Cremaldi, L, Godang, R, Kroeger, R, Summers, Dj, Zhao, Hw, Simard, M, Taras, P, Nicholson, H, De Nardo, G, Lista, L, Monorchio, D, Onorato, G, Sciacca, C, Raven, G, Snoek, Hl, Jessop, Cp, Knoepfel, Kj, Losecco, Jm, Wang, Wf, Corwin, La, Honscheid, K, Kagan, H, Kass, R, Morris, Jp, Rahimi, Am, Regensburger, Jj, Sekula, Sj, Wong, Qk, Blount, Nl, Brau, J, Frey, R, Igonkina, O, Kolb, Ja, Lu, M, Rahmat, R, Sinev, Nb, Strom, D, Strube, J, Torrence, E, Castelli, G, Gagliardi, N, Margoni, M, Morandin, M, Posocco, M, Rotondo, M, Simonetto, F, Stroili, R, Voci, C, Sanchez, Pd, Ben Haim, E, Briand, H, Chauveau, J, Hamon, O, Leruste, P, Ocariz, J, Perez, A, Prendki, J, Sitt, S, Gladney, L, Biasini, M, Manoni, E, Angelini, C, Batignani, G, Bettarini, S, Calderini, G, Carpinelli, M, Cervelli, A, Forti, F, Giorgi, Ma, Lusiani, Alberto, Marchiori, G, Morganti, M, Neri, N, Paoloni, E, Rizzo, G, Walsh, Jj, Pegna, Dl, Lu, C, Olsen, J, Smith, Aj, Telnov, Av, Anulli, F, Baracchini, E, Cavoto, G, Faccini, R, Ferrarotto, F, Ferroni, F, Gaspero, M, Jackson, Pd, Li Gioi, L, Mazzoni, Ma, Morganti, S, Piredda, G, Renga, F, Voena, C, Ebert, M, Hartmann, T, Schroder, H, Waldi, R, Adye, T, Franek, B, Olaiya, Eo, Wilson, Ff, Emery, S, Esteve, L, de Monchenault, Gh, Kozanecki, W, Vasseur, G, Yeche, C, Zito, M, Chen, Xr, Liu, H, Park, W, Purohit, Mv, White, Rm, Wilson, Jr, Allen, Mt, Aston, D, Bartoldus, R, Benitez, Jf, Cenci, R, Coleman, Jp, Convery, Mr, Dingfelder, Jc, Dorfan, J, Dubois Felsmann, Gp, Dunwoodie, W, Field, Rc, Gabareen, Am, Graham, Mt, Grenier, P, Hast, C, Innes, Wr, Kaminski, J, Kelsey, Mh, Kim, H, Kim, P, Kocian, Ml, Leith, Dwg, Li, S, Lindquist, B, Luitz, S, Luth, V, Lynch, Hl, Macfarlane, Db, Marsiske, H, Messner, R, Muller, Dr, Neal, H, Nelson, S, O'Grady, Cp, Ofte, I, Perl, M, Ratcliff, Bn, Roodman, A, Salnikov, Aa, Schindler, Rh, Schwiening, J, Snyder, A, Su, D, Sullivan, Mk, Suzuki, K, Swain, Sk, Thompson, Jm, Va'Vra, J, Wagner, Ap, Weaver, M, West, Ca, Wisniewski, Wj, Wittgen, M, Wright, Dh, Wulsin, Hw, Yarritu, Ak, Yi, K, Young, Cc, Ziegler, V, Burchat, Pr, Edwards, Aj, Miyashita, T, Ahmed, S, Alam, M, Ernst, Ja, Pan, B, Saeed, Ma, Zain, Sb, Spanier, Sm, Wogsland, Bj, Eckmann, R, Ritchie, Jl, Ruland, Am, Schilling, Cj, Schwitters, Rf, Drummond, Bw, Izen, Jm, Lou, Xc, Bianchi, F, Gamba, D, Pelliccioni, M, Bomben, M, Bosisio, L, Cartaro, C, Ricca, G, Lanceri, L, Vitale, L, Azzolini, V, Lopez March, N, Martinez Vidal, F, Milanes, Da, Oyanguren, A, Albert, J, Banerjee, S, Bhuyan, B, Choi, Hhf, Hamano, K, King, Gj, Kowalewski, R, Lewczuk, Mj, Nugent, Im, Roney, Jm, Sobie, Rj, Gershon, Tj, Harrison, Pf, Ilic, J, Latham, Te, Mohanty, Gb, Puccio, Emt, Band, Hr, Chen, X, Dasu, S, Flood, Kt, Pan, Y, Prepost, R, Vuosalo, Co, and Wu, Sl
- Abstract
We present improved measurements of the branching fraction B, the longitudinal polarization fraction f(L), and the direct CP asymmetry A(CP) in the B meson decay channel B(+)->rho(+)rho(0). The data sample was collected with the BABAR detector at SLAC. The results are B(B(+)->rho(+)rho(0))=(23.7 +/- 1.4 +/- 1.4)x10(-6), f(L)=0.950 +/- 0.015 +/- 0.006, and A(CP)=-0.054 +/- 0.055 +/- 0.010, where the uncertainties are statistical and systematic, respectively. Based on these results, we perform an isospin analysis and determine the Cabibbo-Kobayashi-Maskawa phase angle alpha=arg(-V(td)V(tb)(*)/V(ud)V(ub)(*)) to be (92.4(-6.5)(+6.0))degrees.
- Published
- 2009
9. Pumpless extracorporeal CO2removal restores normocapnia and is associated with less regional perfusion in experimental acute lung injury
- Author
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KREYER, S., primary, MUDERS, T., additional, LUEPSCHEN, H., additional, KRICKLIES, C., additional, LINDEN, K., additional, TOLBA, R., additional, VARELMANN, D., additional, ZINSERLING, J., additional, PUTENSEN, C., additional, and WRIGGE, H., additional
- Published
- 2013
- Full Text
- View/download PDF
10. Performance studies of the CMS Strip Tracker before installation
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Adam, W, primary, Bergauer, T, additional, Dragicevic, M, additional, Friedl, M, additional, Frühwirth, R, additional, Hänsel, S, additional, Hrubec, J, additional, Krammer, M, additional, Oberegger, M, additional, Pernicka, M, additional, Schmid, S, additional, Stark, R, additional, Steininger, H, additional, Uhl, D, additional, Waltenberger, W, additional, Widl, E, additional, Mechelen, P Van, additional, Cardaci, M, additional, Beaumont, W, additional, Langhe, E de, additional, Wolf, E A de, additional, Delmeire, E, additional, Hashemi, M, additional, Bouhali, O, additional, Charaf, O, additional, Clerbaux, B, additional, Dewulf, J-P, additional, Elgammal, S, additional, Hammad, G, additional, Lentdecker, G de, additional, Marage, P, additional, Velde, C Vander, additional, Vanlaer, P, additional, Wickens, J, additional, Adler, V, additional, Devroede, O, additional, Weirdt, S De, additional, D'Hondt, J, additional, Goorens, R, additional, Heyninck, J, additional, Maes, J, additional, Mozer, M, additional, Tavernier, S, additional, Lancker, L Van, additional, Mulders, P Van, additional, Villella, I, additional, Wastiels, C, additional, Bonnet, J-L, additional, Bruno, G, additional, Callatay, B De, additional, Florins, B, additional, Giammanco, A, additional, Gregoire, G, additional, Keutgen, Th, additional, Kcira, D, additional, Lemaitre, V, additional, Michotte, D, additional, Militaru, O, additional, Piotrzkowski, K, additional, Quertermont, L, additional, Roberfroid, V, additional, Rouby, X, additional, Teyssier, D, additional, Daubie, E, additional, Anttila, E, additional, Czellar, S, additional, Engström, P, additional, Härkönen, J, additional, Karimäki, V, additional, Kostesmaa, J, additional, Kuronen, A, additional, Lampén, T, additional, Lindén, T, additional, Luukka, P-R, additional, Mäenpää, T, additional, Michal, S, additional, Tuominen, E, additional, Tuominiemi, J, additional, Ageron, M, additional, Baulieu, G, additional, Bonnevaux, A, additional, Boudoul, G, additional, Chabanat, E, additional, Chabert, E, additional, Chierici, R, additional, Contardo, D, additional, Negra, R Della, additional, Dupasquier, T, additional, Gelin, G, additional, Giraud, N, additional, Guillot, G, additional, Estre, N, additional, Haroutunian, R, additional, Lumb, N, additional, Perries, S, additional, Schirra, F, additional, Trocme, B, additional, Vanzetto, S, additional, Agram, J-L, additional, Blaes, R, additional, Drouhin, F, additional, Ernenwein, J-P, additional, Fontaine, J-C, additional, Berst, J-D, additional, Brom, J-M, additional, Didierjean, F, additional, Goerlach, U, additional, Graehling, P, additional, Gross, L, additional, Hosselet, J, additional, Juillot, P, additional, Lounis, A, additional, Maazouzi, C, additional, Olivetto, C, additional, Strub, R, additional, Hove, P Van, additional, Anagnostou, G, additional, Brauer, R, additional, Esser, H, additional, Feld, L, additional, Karpinski, W, additional, Klein, K, additional, Kukulies, C, additional, Olzem, J, additional, Ostapchuk, A, additional, Pandoulas, D, additional, Pierschel, G, additional, Raupach, F, additional, Schael, S, additional, Schwering, G, additional, Sprenger, D, additional, Thomas, M, additional, Weber, M, additional, Wittmer, B, additional, Wlochal, M, additional, Beissel, F, additional, Bock, E, additional, Flugge, G, additional, Gillissen, C, additional, Hermanns, T, additional, Heydhausen, D, additional, Jahn, D, additional, Kaussen, G, additional, Linn, A, additional, Perchalla, L, additional, Poettgens, M, additional, Pooth, O, additional, Stahl, A, additional, Zoeller, M H, additional, Buhmann, P, additional, Butz, E, additional, Flucke, G, additional, Hamdorf, R, additional, Hauk, J, additional, Klanner, R, additional, Pein, U, additional, Schleper, P, additional, Steinbrück, G, additional, Blüm, P, additional, Boer, W De, additional, Dierlamm, A, additional, Dirkes, G, additional, Fahrer, M, additional, Frey, M, additional, Furgeri, A, additional, Hartmann, F, additional, Heier, S, additional, Hoffmann, K-H, additional, Kaminski, J, additional, Ledermann, B, additional, Liamsuwan, T, additional, Müller, S, additional, Müller, Th, additional, Schilling, F-P, additional, Simonis, H-J, additional, Steck, P, additional, Zhukov, V, additional, Cariola, P, additional, Robertis, G De, additional, Ferorelli, R, additional, Fiore, L, additional, Preda, M, additional, Sala, G, additional, Silvestris, L, additional, Tempesta, P, additional, Zito, G, additional, Creanza, D, additional, Filippis, N De, additional, Palma, M De, additional, Giordano, D, additional, Maggi, G, additional, Manna, N, additional, My, S, additional, Selvaggi, G, additional, Albergo, S, additional, Chiorboli, M, additional, Costa, S, additional, Galanti, M, additional, Giudice, N, additional, Guardone, N, additional, Noto, F, additional, Potenza, R, additional, Saizu, M A, additional, Sparti, V, additional, Sutera, C, additional, Tricomi, A, additional, Tuvè, C, additional, Brianzi, M, additional, Civinini, C, additional, Maletta, F, additional, Manolescu, F, additional, Meschini, M, additional, Paoletti, S, additional, Sguazzoni, G, additional, Broccolo, B, additional, Ciulli, V, additional, D'Alessandro, R, additional, Focardi, E, additional, Frosali, S, additional, Genta, C, additional, Landi, G, additional, Lenzi, P, additional, Macchiolo, A, additional, Magini, N, additional, Parrini, G, additional, Scarlini, E, additional, Cerati, G, additional, Azzi, P, additional, Bacchetta, N, additional, Candelori, A, additional, Dorigo, T, additional, Kaminsky, A, additional, Karaevski, S, additional, Khomenkov, V, additional, Reznikov, S, additional, Tessaro, M, additional, Bisello, D, additional, Mattia, M De, additional, Giubilato, P, additional, Loreti, M, additional, Mattiazzo, S, additional, Nigro, M, additional, Paccagnella, A, additional, Pantano, D, additional, Pozzobon, N, additional, Tosi, M, additional, Bilei, G M, additional, Checcucci, B, additional, Fanò, L, additional, Servoli, L, additional, Ambroglini, F, additional, Babucci, E, additional, Benedetti, D, additional, Biasini, M, additional, Caponeri, B, additional, Covarelli, R, additional, Giorgi, M, additional, Lariccia, P, additional, Mantovani, G, additional, Marcantonini, M, additional, Postolache, V, additional, Santocchia, A, additional, Spiga, D, additional, Bagliesi, G, additional, Balestri, G, additional, Berretta, L, additional, Bianucci, S, additional, Boccali, T, additional, Bosi, F, additional, Bracci, F, additional, Castaldi, R, additional, Ceccanti, M, additional, Cecchi, R, additional, Cerri, C, additional, Cucoanes, A S, additional, Dell'Orso, R, additional, Dobur, D, additional, Dutta, S, additional, Giassi, A, additional, Giusti, S, additional, Kartashov, D, additional, Kraan, A, additional, Lomtadze, T, additional, Lungu, G A, additional, Magazzù, G, additional, Mammini, P, additional, Mariani, F, additional, Martinelli, G, additional, Moggi, A, additional, Palla, F, additional, Palmonari, F, additional, Petragnani, G, additional, Profeti, A, additional, Raffaelli, F, additional, Rizzi, D, additional, Sanguinetti, G, additional, Sarkar, S, additional, Sentenac, D, additional, Serban, A T, additional, Slav, A, additional, Soldani, A, additional, Spagnolo, P, additional, Tenchini, R, additional, Tolaini, S, additional, Venturi, A, additional, Verdini, P G, additional, Vos, M, additional, Zaccarelli, L, additional, Avanzini, C, additional, Basti, A, additional, Benucci, L, additional, Bocci, A, additional, Cazzola, U, additional, Fiori, F, additional, Linari, S, additional, Massa, M, additional, Messineo, A, additional, Segneri, G, additional, Tonelli, G, additional, Azzurri, P, additional, Bernardini, J, additional, Borrello, L, additional, Calzolari, F, additional, Foà, L, additional, Gennai, S, additional, Ligabue, F, additional, Petrucciani, G, additional, Rizzi, A, additional, Yang, Z, additional, Benotto, F, additional, Demaria, N, additional, Dumitrache, F, additional, Farano, R, additional, Borgia, M A, additional, Castello, R, additional, Costa, M, additional, Migliore, E, additional, Romero, A, additional, Abbaneo, D, additional, Abbas, M, additional, Ahmed, I, additional, Akhtar, I, additional, Albert, E, additional, Bloch, C, additional, Breuker, H, additional, Butt, S, additional, Buchmuller, O, additional, Cattai, A, additional, Delaere, C, additional, Delattre, M, additional, Edera, L M, additional, Engstrom, P, additional, Eppard, M, additional, Gateau, M, additional, Gill, K, additional, Giolo-Nicollerat, A-S, additional, Grabit, R, additional, Honma, A, additional, Huhtinen, M, additional, Kloukinas, K, additional, Kortesmaa, J, additional, Kottelat, L J, additional, Leonardo, N, additional, Ljuslin, C, additional, Mannelli, M, additional, Masetti, L, additional, Marchioro, A, additional, Mersi, S, additional, Mirabito, L, additional, Muffat-Joly, J, additional, Onnela, A, additional, Paillard, C, additional, Pal, I, additional, Pernot, J F, additional, Petagna, P, additional, Petit, P, additional, Piccut, C, additional, Pioppi, M, additional, Postema, H, additional, Ranieri, R, additional, Ricci, D, additional, Rolandi, G, additional, Ronga, F, additional, Sigaud, C, additional, Syed, A, additional, Siegrist, P, additional, Tropea, P, additional, Troska, J, additional, Tsirou, A, additional, Donckt, M Vander, additional, Vasey, F, additional, Alagoz, E, additional, Amsler, C, additional, Chiochia, V, additional, Regenfus, C, additional, Robmann, P, additional, Rochet, J, additional, Rommerskirchen, T, additional, Schmidt, A, additional, Steiner, S, additional, Wilke, L, additional, Church, I, additional, Cole, J, additional, Coughlan, J, additional, Gay, A, additional, Taghavi, S, additional, Tomalin, I, additional, Bainbridge, R, additional, Cripps, N, additional, Fulcher, J, additional, Hall, G, additional, Noy, M, additional, Pesaresi, M, additional, Radicci, V, additional, Raymond, D M, additional, Sharp, P, additional, Stoye, M, additional, Wingham, M, additional, Zorba, O, additional, Goitom, I, additional, Hobson, P R, additional, Reid, I, additional, Teodorescu, L, additional, Hanson, G, additional, Jeng, G-Y, additional, Liu, H, additional, Pasztor, G, additional, Satpathy, A, additional, Stringer, R, additional, Mangano, B, additional, Affolder, K, additional, Affolder, T, additional, Allen, A, additional, Barge, D, additional, Burke, S, additional, Callahan, D, additional, Campagnari, C, additional, Crook, A, additional, D'Alfonso, M, additional, Dietch, J, additional, Garberson, J, additional, Hale, D, additional, Incandela, H, additional, Incandela, J, additional, Jaditz, S, additional, Kalavase, P, additional, Kreyer, S, additional, Kyre, S, additional, Lamb, J, additional, Guinness, C Mc, additional, Mills, C, additional, Nguyen, H, additional, Nikolic, M, additional, Lowette, S, additional, Rebassoo, F, additional, Ribnik, J, additional, Richman, J, additional, Rubinstein, N, additional, Sanhueza, S, additional, Shah, Y, additional, Simms, L, additional, Staszak, D, additional, Stoner, J, additional, Stuart, D, additional, Swain, S, additional, Vlimant, J-R, additional, White, D, additional, Ulmer, K A, additional, Wagner, S R, additional, Bagby, L, additional, Bhat, P C, additional, Burkett, K, additional, Cihangir, S, additional, Gutsche, O, additional, Jensen, H, additional, Johnson, M, additional, Luzhetskiy, N, additional, Mason, D, additional, Miao, T, additional, Moccia, S, additional, Noeding, C, additional, Ronzhin, A, additional, Skup, E, additional, Spalding, W J, additional, Spiegel, L, additional, Tkaczyk, S, additional, Yumiceva, F, additional, Zatserklyaniy, A, additional, Zerev, E, additional, Anghel, I, additional, Bazterra, V E, additional, Gerber, C E, additional, Khalatian, S, additional, Shabalina, E, additional, Baringer, P, additional, Bean, A, additional, Chen, J, additional, Hinchey, C, additional, Martin, C, additional, Moulik, T, additional, Robinson, R, additional, Gritsan, A V, additional, Lae, C K, additional, Tran, N V, additional, Everaerts, P, additional, Hahn, K A, additional, Harris, P, additional, Nahn, S, additional, Rudolph, M, additional, Sung, K, additional, Betchart, B, additional, Demina, R, additional, Gotra, Y, additional, Korjenevski, S, additional, Miner, D, additional, Orbaker, D, additional, Christofek, L, additional, Hooper, R, additional, Landsberg, G, additional, Nguyen, D, additional, Narain, M, additional, Speer, T, additional, and Tsang, K V, additional
- Published
- 2009
- Full Text
- View/download PDF
11. Effect of Spontaneus Breathing during APRV on Cerebral Perfusion.
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Kreyer, S, primary, Zinserling, J, additional, Wrigge, H, additional, Berg, A, additional, Sohle, M, additional, Muders, T, additional, Putensen, C, additional, and Hering, R, additional
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- 2009
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12. Pumpless extracorporeal CO2 removal restores normocapnia and is associated with less regional perfusion in experimental acute lung injury.
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KREYER, S., MUDERS, T., LUEPSCHEN, H., KRICKLIES, C., LINDEN, K., TOLBA, R., VARELMANN, D., ZINSERLING, J., PUTENSEN, C., and WRIGGE, H.
- Subjects
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EXTRACORPOREAL carbon dioxide removal , *LUNG injuries , *DRUG infusion pumps , *ACIDOSIS , *ADRENAL glands - Abstract
Background Lung protective ventilation may lead to hypoventilation with subsequent hypercapnic acidosis ( HA). If HA cannot be tolerated or occurs despite increasing respiratory rate or buffering, extracorporeal CO2-removal using a percutaneous extracorporeal lung assist (p ECLA) is an option. We hypothesised that compensation of HA using p ECLA impairs regional perfusion. To test this hypothesis we determined organ blood flows in a lung-injury model with combined hypercapnic and metabolic acidosis. Methods After induction of lung injury using hydrochloric acid ( HCl) aspiration and metabolic acidosis by intravenous HCl infusion in nine pigs, an arterial-venous p ECLA device was inserted. In randomised order, four treatments were tested: p ECLA shunt (1) with and (2) without HA, and clamped p ECLA shunt (3) with and (4) without HA. Regional blood flows were measured with the coloured microsphere technique. Results HA resulted in higher perfusion in adrenal glands, spleen and parts of splanchnic area ( P < 0.05) compared with normocapnia. During CO2-removal with p ECLA, regional perfusion decreased to levels comparable with those without p ECLA and normocapnia. Cardiac output ( CO) increased during HA without a p ECLA shunt and was highest during HA with a p ECLA shunt compared with normocapnia. During CO2-removal with p ECLA, this variable decreased but stayed higher than during normocapnia with clamped p ECLA shunt ( P < 0.05). Conclusion In our lung-injury model, HA was associated with increased systemic and regional blood flow in several organs. p ECLA provides effective CO2 removal, requiring a higher CO for perfusion of the p ECLA device without improvement of regional organ perfusion. [ABSTRACT FROM AUTHOR]
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- 2014
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13. Effects of spontaneous breathing during airway pressure release ventilation on cerebral and spinal cord perfusion in experimental acute lung injury.
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Kreyer S, Putensen C, Berg A, Soehle M, Muders T, Wrigge H, Zinserling J, and Hering R
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- 2010
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14. Performance studies of the CMS Strip Tracker before installation
- Author
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Adam, W., Bergauer, T., Dragicevic, M., Friedl, M., Fruhwirth, R., Hansel, S., Hrubec, J., Krammer, M., Oberegger, M., Pernicka, M., Schmid, S., Stark, R., Steininger, H., Uhl, D., Waltenberger, W., Widl, E., Van Mechelen, P., Cardaci, M., Beaumont, W., De Langhe, E., de Wolf, E.A., Delmeire, E., Hashemi, M., Bouhali, O., Charaf, O., Clerbaux, B., Dewulf, J.P., Elgammal, S., Hammad, G., G. De, Lentdecker, Marage, P., Velde, C.V., Vanlaer, P., Wickens, J., Adler, V., Devroede, O., S. 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De, Lentdecker, Marage, P., Velde, C.V., Vanlaer, P., Wickens, J., Adler, V., Devroede, O., S. 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Hosselet, J., Juillot, P., Lounis, A., Maazouzi, C., Olivetto, C., Strub, R., Van Hove, P., Anagnostou, G., Brauer, R., Esser, H., Feld, L., Karpinski, W., Klein, K., Kukulies, C., Olzem, J., Ostapchuk, A., Pandoulas, D., Pierschel, G., Raupach, F., Schael, S., Schwering, G., Sprenger, D., Thomas, M., Weber, M., Wittmer, B., Wlochal, M., Beissel, F., Bock, E., Flugge, G., Gillissen, C., Hermanns, T., Heydhausen, D., Jahn, D., Kaussen, G., Linn, A., Perchalla, L., Poettgens, M., Pooth, O., Stahl, A., Zoeller, M.H., Buhmann, P., Butz, E., Flucke, G., Hamdorf, R., Hauk, J., Klanner, R., Pein, U., Schleper, P., Steinbruck, G., Blum, P., de Boer, W., Dierlamm, A., Dirkes, G., Fahrer, M., Frey, M., Furgeri, A., Hartmann, F., Heier, S., Hoffmann, K.H., Kaminski, J., Ledermann, B., Liamsuwan, T., Muller, S., Muller, T., Schilling, F.P., Simonis, H.J., Steck, P., Zhukov, V., Cariola, P., De Robertis, G., Ferorelli, R., Fiore, L., Preda, M., Sala, G., Silvestris, L., Tempesta, P., Zito, G., 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- Abstract
In March 2007 the assembly of the Silicon Strip Tracker was completed at the Tracker Integration Facility at CERN. Nearly 15% of the detector was instrumented using cables, fiber optics, power supplies, and electronics intended for the operation at the LHC. A local chiller was used to circulate the coolant for low temperature operation. In order to understand the efficiency and alignment of the strip tracker modules, a cosmic ray trigger was implemented. From March through July 4.5 million triggers were recorded. This period, referred to as the Sector Test, provided practical experience with the operation of the Tracker, especially safety, data acquisition, power, and cooling systems. This paper describes the performance of the strip system during the Sector Test, which consisted of five distinct periods defined by the coolant temperature. Significant emphasis is placed on comparisons between the data and results from Monte Carlo studies
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15. Stand-alone cosmic muon reconstruction before installation of the CMS silicon strip tracker
- Author
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Adam, W., Bergauer, T., Dragicevic, M., Friedl, M., Fruhwirth, R., Hansel, S., Hrubec, J., Krammer, M., Oberegger, M., Pernicka, M., Schmid, S., Stark, R., Steininger, H., Uhl, D., Waltenberger, W., Widl, E., Van Mechelen, P., Cardaci, M., Beaumont, W., De Langhe, E., de Wolf, E.A., Delmeire, E., Hashemi, M., Bouhali, O., Charaf, O., Clerbaux, B., Dewulf, J.P., Elgammal, S., Hammad, G., De Lentdecker, G., Marage, P., Velde, C.V., Vanlaer, P., Wickens, J., Adler, V., Devroede, O., De Weirdt, S., D'Hondt, J., Goorens, R., Heyninck, J., Maes, J., Mozer, M., Tavernier, S., Van Lancker, L., Van Mulders, P., Villella, I., Wastiels, C., Bonnet, J.L., Bruno, G., De Callatay, B., Florins, B., Giammanco, A., Gregoire, G., Keutgen, T., Kcira, D., Lemaitre, V., Michotte, D., Militaru, O., Piotrzkowski, K., Quertermont, L., Roberfroid, V., Rouby, X., Teyssier, D., Daubie, E., Anttila, E., Czellar, S., Engstrom, P., Harkonen, J., Karimaki, V., Kostesmaa, J., Kuronen, A., Lampen, T., Linden, T., Luukka, P.R., Maenpaa, T., Michal, S., Tuominen, E., Tuominiemi, J., Ageron, M., Baulieu, G., Bonnevaux, A., Boudoul, G., Chabanat, E., Chabert, E., Chierici, R., Contardo, D., Della Negra, R., Dupasquier, T., Gelin, G., Giraud, N., Guillot, G., Estre, N., Haroutunian, R., Lumb, N., Perries, S., Schirra, F., Trocme, B., Vanzetto, S., Agram, J.L., Blaes, R., Drouhin, F., Ernenwein, J.P., Fontaine, J.C., Berst, J.D., Brom, J.M., Didierjean, F., Goerlach, U., Graehling, P., Gross, L., Hosselet, J., Juillot, P., Lounis, A., Maazouzi, C., Olivetto, C., Strub, R., Van Hove, P., Anagnostou, G., Brauer, R., Esser, H., Feld, L., Karpinski, W., Klein, K., Kukulies, C., Olzem, J., Ostapchuk, A., Pandoulas, D., Pierschel, G., Raupach, F., Schael, S., Schwering, G., Sprenger, D., Thomas, M., Weber, M., Wittmer, B., Wlochal, M., Beissel, F., Bock, E., Flugge, G., Gillissen, C., Hermanns, T., Heydhausen, D., Jahn, D., Kaussen, G., Linn, A., Perchalla, L., Poettgens, M., Pooth, O., Stahl, A., Zoeller, 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R., Steininger, H., Uhl, D., Waltenberger, W., Widl, E., Van Mechelen, P., Cardaci, M., Beaumont, W., De Langhe, E., de Wolf, E.A., Delmeire, E., Hashemi, M., Bouhali, O., Charaf, O., Clerbaux, B., Dewulf, J.P., Elgammal, S., Hammad, G., De Lentdecker, G., Marage, P., Velde, C.V., Vanlaer, P., Wickens, J., Adler, V., Devroede, O., De Weirdt, S., D'Hondt, J., Goorens, R., Heyninck, J., Maes, J., Mozer, M., Tavernier, S., Van Lancker, L., Van Mulders, P., Villella, I., Wastiels, C., Bonnet, J.L., Bruno, G., De Callatay, B., Florins, B., Giammanco, A., Gregoire, G., Keutgen, T., Kcira, D., Lemaitre, V., Michotte, D., Militaru, O., Piotrzkowski, K., Quertermont, L., Roberfroid, V., Rouby, X., Teyssier, D., Daubie, E., Anttila, E., Czellar, S., Engstrom, P., Harkonen, J., Karimaki, V., Kostesmaa, J., Kuronen, A., Lampen, T., Linden, T., Luukka, P.R., Maenpaa, T., Michal, S., Tuominen, E., Tuominiemi, J., Ageron, M., Baulieu, G., Bonnevaux, A., Boudoul, G., Chabanat, E., Chabert, E., 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Bisello, D., De Mattia, M., Giubilato, P., Loreti, M., Mattiazzo, S., Nigro, M., Paccagnella, A., Pantano, D., Pozzobon, N., Tosi, M., Bilei, G.M., Checcucci, B., Fano, L., Servoli, L., Ambroglini, F., Babucci, E., Benedetti, D., Biasini, M., Caponeri, B., Covarelli, R., Giorgi, M., Lariccia, P., Mantovani, G., Marcantonini, M., Postolache, V., Santocchia, A., Spiga, D., Bagliesi, G., Balestri, G., Berretta, L., Bianucci, S., Boccali, T., Bosi, F., Bracci, F., Castaldi, R., Ceccanti, M., Cecchi, R., Cerri, C., Cucoanes, A.S., Dell'Orso, R., Dobur, D., Dutta, S., Giassi, A., Giusti, S., Kartashov, D., Kraan, A., Lomtadze, T., Lungu, G.A., Magazzu, G., Mammini, P., Mariani, F., Martinelli, G., Moggi, A., Palla, F., Palmonari, F., Petragnani, G., Profeti, A., Raffaelli, F., Rizzi, D., Sanguinetti, G., Sarkar, S., Sentenac, D., Serban, A.T., Slav, A., Soldani, A., Spagnolo, P., Tenchini, R., Tolaini, S., Venturi, A., Verdini, P.G., Vos, M., Zaccarelli, L., Avanzini, C., Basti, A., Benucci, L., Bocci, A., Cazzola, U., Fiori, F., Linari, S., Massa, M., Messineo, A., Segneri, G., Tonelli, G., Azzurri, P., Bernardini, J., Borrello, L., Calzolari, F., Foa, L., Gennai, S., Ligabue, F., Petrucciani, G., Rizzi, A., Yang, Z., Benotto, F., Demaria, N., Dumitrache, F., Farano, R., Borgia, M.A., Castello, R., Costa, M., Migliore, E., Romero, A., Abbaneo, D., Abbas, M., Ahmed, I., Akhtar, I., Albert, E., Bloch, C., Breuker, H., Butt, S., Buchmuller, O., Cattai, A., Delaere, C., Delattre, M., Edera, L.M., Eppard, M., Gateau, M., Gill, K., Giolo-Nicollerat, A.S., Grabit, R., Honma, A., Huhtinen, M., Kloukinas, K., Kortesmaa, J., Kottelat, L.J., Leonardo, N., Ljuslin, C., Mannelli, M., Masetti, L., Marchioro, A., Mersi, S., Mirabito, L., Muffat-Joly, J., Onnela, A., Paillard, C., Pal, I., Pernot, J.F., Petagna, P., Petit, P., Piccut, C., Pioppi, M., Postema, H., Ranieri, R., Ricci, D., Rolandi, G., Ronga, F., Sigaud, C., Syed, A., Siegrist, P., Tropea, P., Troska, J., Tsirou, A., Donckt, M.V., Vasey, F., Alagoz, E., Amsler, C., Chiochia, V., Regenfus, C., Robmann, P., Rochet, J., Rommerskirchen, T., Schmidt, A., Steiner, S., Wilke, L., Church, I., Cole, J., Coughlan, J., Gay, A., Taghavi, S., Tomalin, I., Bainbridge, R., Cripps, N., Fulcher, J., Hall, G., Noy, M., Pesaresi, M., Radicci, V., Raymond, D.M., Sharp, P., Stoye, M., Wingham, M., Zorba, O., Goitom, I., Hobson, P.R., Reid, I., Teodorescu, L., Hanson, G., Jeng, G.Y., Liu, H., Pasztor, G., Satpathy, A., Stringer, R., Mangano, B., Affolder, K., Affolder, T., Allen, A., Barge, D., Burke, S., Callahan, D., Campagnari, C., Crook, A., d'Alfonso, M., Dietch, J., Garberson, J., Hale, D., Incandela, H., Incandela, J., Jaditz, S., Kalavase, P., Kreyer, S., Kyre, S., Lamb, J., Mc Guinness, C., Mills, C., Nguyen, H., Nikolic, M., Lowette, S., Rebassoo, F., Ribnik, J., Richman, J., Rubinstein, N., Sanhueza, S., Shah, Y., Simms, L., Staszak, D., Stoner, J., Stuart, D., Swain, S., Vlimant, J.R., White, D., Ulmer, K.A., Wagner, S.R., Bagby, L., Bhat, P.C., Burkett, K., Cihangir, S., Gutsche, O., Jensen, H., Johnson, M., Luzhetskiy, N., Mason, D., Miao, T., Moccia, S., Noeding, C., Ronzhin, A., Skup, E., Spalding, W.J., Spiegel, L., Tkaczyk, S., Yumiceva, F., Zatserklyaniy, A., Zerev, E., Anghel, I., Bazterra, V.E., Gerber, C.E., Khalatian, S., Shabalina, E., Baringer, P., Bean, A., Chen, J., Hinchey, C., Martin, C., Moulik, T., Robinson, R., Gritsan, A.V., Lae, C.K., Tran, N.V., Everaerts, P., Hahn, K.A., Harris, P., Nahn, S., Rudolph, M., Sung, K., Betchart, B., Demina, R., Gotra, Y., Korjenevski, S., Miner, D., Orbaker, D., Christofek, L., Hooper, R., Landsberg, G., Nguyen, D., Narain, M., Speer, T., and Tsang, K.V.
- Abstract
The subsystems of the CMS silicon strip tracker were integrated and commissioned at the Tracker Integration Facility (TIF) in the period from November 2006 to July 2007. As part of the commissioning, large samples of cosmic ray data were recorded under various running conditions in the absence of a magnetic field. Cosmic rays detected by scintillation counters were used to trigger the readout of up to 15 % of the final silicon strip detector, and over 4.7 million events were recorded. This document describes the cosmic track reconstruction and presents results on the performance of track and hit reconstruction as from dedicated analyses
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16. Performance studies of the CMS Strip Tracker before installation
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CMS Collaboration, Adam, W, Bergauer, T, Dragicevic, M, Friedl, M, Fruehwirth, R, Haensel, S, Hrubec, J, Krammer, M, Oberegger, M, Pernicka, M, Schmid, S, Stark, R, Steininger, H, Uhl, D, Waltenberger, W, Widl, E, Van Mechelen, P, Cardaci, M, Beaumont, W, De Langhe, E, De Wolf, EA, Delmeire, E, Hashemi, M, Bouhali, O, Charaf, O, Clerbaux, B, Dewulf, J, Elgammal, S, Hammad, G, De Lentdecker, G, Marage, P, Velde, CV, Vanlaer, P, Wickens, J, Adler, V, Devroede, O, De Weirdt, S, D'Hondt, J, Goorens, R, Heyninck, J, Maes, J, Mozer, M, Tavernier, S, Van Lancker, L, Van Mulders, P, Villella, I, Wastiels, C, Bonnet, J, Bruno, G, De Callatay, B, Florins, B, Giammanco, A, Gregoire, G, Keutgen, T, Kcira, D, Lemaitre, V, Michotte, D, Militaru, O, Piotrzkowski, K, Quertermont, L, Roberfroid, V, Rouby, X, Teyssier, D, Daubie, E, Anttila, E, Czellar, S, Engstrom, P, Harkonen, J, Karimaki, V, Kostesmaa, J, Kuronen, A, Lampen, T, Linden, T, Luukka, P, Maenpaa, T, Michal, S, Tuominen, E, Tuominiemi, J, Ageron, M, Baulieu, G, Bonnevaux, A, Boudoul, G, Chabanat, E, Chabert, E, Chierici, R, Contardo, D, Della Negra, R, Dupasquier, T, Gelin, G, Giraud, N, Guillot, G, Estre, N, Haroutunian, R, Lumb, N, Perries, S, Schirra, F, Trocme, B, Vanzetto, S, Agram, J, Blaes, R, Drouhin, F, Ernenwein, J, Fontaine, J, Berst, J, Brom, J, Didierjean, F, Goerlach, U, Graehling, P, Gross, L, Hosselet, J, Juillot, P, Lounis, A, Maazouzi, C, Olivetto, C, Strub, R, Van Hove, P, Anagnostou, G, Brauer, R, Esser, H, Feld, L, Karpinski, W, Klein, K, Kukulies, C, Olzem, J, Ostapchuk, A, Pandoulas, D, Pierschel, G, Raupach, F, Schael, S, Schwering, G, Sprenger, D, Thomas, M, Weber, M, Wittmer, B, Wlochal, M, Beissel, F, Bock, E, Flugge, G, Gillissen, C, Hermanns, T, Heydhausen, D, Jahn, D, Kaussen, G, Linn, A, Perchalla, L, Poettgens, M, Pooth, O, Stahl, A, Zoeller, MH, Buhmann, P, Butz, E, Flucke, G, Hamdorf, R, Hauk, J, Klanner, R, Pein, U, Schleper, P, Steinbrueck, G, Bluem, P, De Boer, W, Dierlamm, A, Dirkes, G, Fahrer, M, Frey, M, Furgeri, A, Hartmann, F, Heier, S, Hoffmann, K, Kaminski, J, Ledermann, B, Liamsuwan, T, Mueller, S, Mueller, T, Schilling, F, Simonis, H, Steck, P, Zhukov, V, Cariola, P, De Robertis, G, Ferorelli, R, Fiore, L, Preda, M, Sala, G, Silvestris, L, Tempesta, P, Zito, G, Creanza, D, De Filippis, N, De Palma, M, Giordano, D, Maggi, G, Manna, N, My, S, Selvaggi, G, Albergo, S, Chiorboli, M, Costa, S, Galanti, M, Giudice, N, Guardone, N, Noto, F, Potenza, R, Saizu, MA, Sparti, V, Sutera, C, Tricomi, A, Tuve, C, Brianzi, M, Civinini, C, Maletta, F, Manolescu, F, Meschini, M, Paoletti, S, Sguazzoni, G, Broccolo, B, Ciulli, V, D'Alessandro, R, Focardi, E, Frosali, S, Genta, C, Landi, G, Lenzi, P, Macchiolo, A, Magini, N, Parrini, G, Scarlini, E, Cerati, G, Azzi, P, Bacchetta, N, Candelori, A, Dorigo, T, Kaminsky, A, Karaevski, S, Khomenkov, V, Reznikov, S, Tessaro, M, Bisello, D, De Mattia, M, Giubilato, P, Loreti, M, Mattiazzo, S, Nigro, M, Paccagnella, A, Pantano, D, Pozzobon, N, Tosi, M, Bilei, GM, Checcucci, B, Fano, L, Servoli, L, Ambroglini, F, Babucci, E, Benedetti, D, Biasini, M, Caponeri, B, Covarelli, R, Giorgi, M, Lariccia, P, Mantovani, G, Marcantonini, M, Postolache, V, Santocchia, A, Spiga, D, Bagliesi, G, Balestri, G, Berretta, L, Bianucci, S, Boccali, T, Bosi, F, Bracci, F, Castaldi, R, Ceccanti, M, Cecchi, R, Cerri, C, Cucoanes, AS, Dell'Orso, R, Dobur, D, Dutta, S, Giassi, A, Giusti, S, Kartashov, D, Kraan, A, Lomtadze, T, Lungu, GA, Magazzu, G, Mammini, P, Mariani, F, Martinelli, G, Moggi, A, Palla, F, Palmonari, F, Petragnani, G, Profeti, A, Raffaelli, F, Rizzi, D, Sanguinetti, G, Sarkar, S, Sentenac, D, Serban, AT, Slav, A, Soldani, A, Spagnolo, P, Tenchini, R, Tolaini, S, Venturi, A, Verdini, PG, Vos, M, Zaccarelli, L, Avanzini, C, Basti, A, Benucci, L, Bocci, A, Cazzola, U, Fiori, F, Linari, S, Massa, M, Messineo, A, Segneri, G, Tonelli, G, Azzurri, P, Bernardini, J, Borrello, L, Calzolari, F, Foa, L, Gennai, S, Ligabue, F, Petrucciani, G, Rizzi, A, Yang, Z, Benotto, F, Demaria, N, Dumitrache, F, Farano, R, Borgia, MA, Castello, R, Costa, M, Migliore, E, Romero, A, Abbaneo, D, Abbas, M, Ahmed, I, Akhtar, I, Albert, E, Bloch, C, Breuker, H, Butt, S, Buchmuller, O, Cattai, A, Delaere, C, Delattre, M, Edera, LM, Eppard, M, Gateau, M, Gill, K, Giolo-Nicollerat, A, Grabit, R, Honma, A, Huhtinen, M, Kloukinas, K, Kortesmaa, J, Kottelat, LJ, Leonardo, N, Ljuslin, C, Mannelli, M, Masetti, L, Marchioro, A, Mersi, S, Mirabito, L, Muffat-Joly, J, Onnela, A, Paillard, C, Pal, I, Pernot, JF, Petagna, P, Petit, P, Piccut, C, Pioppi, M, Postema, H, Ranieri, R, Ricci, D, Rolandi, G, Ronga, F, Sigaud, C, Syed, A, Siegrist, P, Tropea, P, Troska, J, Tsirou, A, Donckt, MV, Vasey, F, Alagoz, E, Amsler, C, Chiochia, V, Regenfus, C, Robmann, P, Rochet, J, Rommerskirchen, T, Schmidt, A, Steiner, S, Wilke, L, Church, I, Cole, J, Coughlan, J, Gay, A, Taghavi, S, Tomalin, I, Bainbridge, R, Cripps, N, Fulcher, J, Hall, G, Noy, M, Pesaresi, M, Radicci, V, Raymond, DM, Sharp, P, Stoye, M, Wingham, M, Zorba, O, Goitom, I, Hobson, PR, Reid, I, Teodorescu, L, Hanson, G, Jeng, G, Liu, H, Pasztor, G, Satpathy, A, Stringer, R, Mangano, B, Affolder, K, Affolder, T, Allen, A, Barge, D, Burke, S, Callahan, D, Campagnari, C, Crook, A, D'Alfonso, M, Dietch, J, Garberson, J, Hale, D, Incandela, H, Incandela, J, Jaditz, S, Kalavase, P, Kreyer, S, Kyre, S, Lamb, J, Mc Guinness, C, Mills, C, Nguyen, H, Nikolic, M, Lowette, S, Rebassoo, F, Ribnik, J, Richman, J, Rubinstein, N, Sanhueza, S, Shah, Y, Simms, L, Staszak, D, Stoner, J, Stuart, D, Swain, S, Vlimant, J, White, D, Ulmer, KA, Wagner, SR, Bagby, L, Bhat, PC, Burkett, K, Cihangir, S, Gutsche, O, Jensen, H, Johnson, M, Luzhetskiy, N, Mason, D, Miao, T, Moccia, S, Noeding, C, Ronzhin, A, Skup, E, Spalding, WJ, Spiegel, L, Tkaczyk, S, Yumiceva, F, Zatserklyaniy, A, Zerev, E, Anghel, I, Bazterra, VE, Gerber, CE, Khalatian, S, Shabalina, E, Baringer, P, Bean, A, Chen, J, Hinchey, C, Martin, C, Moulik, T, Robinson, R, Gritsan, AV, Lae, CK, Tran, NV, Everaerts, P, Hahn, KA, Harris, P, Nahn, S, Rudolph, M, Sung, K, Betchart, B, Demina, R, Gotra, Y, Korjenevski, S, Miner, D, Orbaker, D, Christofek, L, Hooper, R, Landsberg, G, Nguyen, D, Narain, M, Speer, T, Tsang, KV, CMS Collaboration, Adam, W, Bergauer, T, Dragicevic, M, Friedl, M, Fruehwirth, R, Haensel, S, Hrubec, J, Krammer, M, Oberegger, M, Pernicka, M, Schmid, S, Stark, R, Steininger, H, Uhl, D, Waltenberger, W, Widl, E, Van Mechelen, P, Cardaci, M, Beaumont, W, De Langhe, E, De Wolf, EA, Delmeire, E, Hashemi, M, Bouhali, O, Charaf, O, Clerbaux, B, Dewulf, J, Elgammal, S, Hammad, G, De Lentdecker, G, Marage, P, Velde, CV, Vanlaer, P, Wickens, J, Adler, V, Devroede, O, De Weirdt, S, D'Hondt, J, Goorens, R, Heyninck, J, Maes, J, Mozer, M, Tavernier, S, Van Lancker, L, Van Mulders, P, Villella, I, Wastiels, C, Bonnet, J, Bruno, G, De Callatay, B, Florins, B, Giammanco, A, Gregoire, G, Keutgen, T, Kcira, D, Lemaitre, V, Michotte, D, Militaru, O, Piotrzkowski, K, Quertermont, L, Roberfroid, V, Rouby, X, Teyssier, D, Daubie, E, Anttila, E, Czellar, S, Engstrom, P, Harkonen, J, Karimaki, V, Kostesmaa, J, Kuronen, A, Lampen, T, Linden, T, Luukka, P, Maenpaa, T, Michal, S, Tuominen, E, Tuominiemi, J, Ageron, M, Baulieu, G, Bonnevaux, A, Boudoul, G, Chabanat, E, Chabert, E, Chierici, R, Contardo, D, Della Negra, R, Dupasquier, T, Gelin, G, Giraud, N, Guillot, G, Estre, N, Haroutunian, R, Lumb, N, Perries, S, Schirra, F, Trocme, B, Vanzetto, S, Agram, J, Blaes, R, Drouhin, F, Ernenwein, J, Fontaine, J, Berst, J, Brom, J, Didierjean, F, Goerlach, U, Graehling, P, Gross, L, Hosselet, J, Juillot, P, Lounis, A, Maazouzi, C, Olivetto, C, Strub, R, Van Hove, P, Anagnostou, G, Brauer, R, Esser, H, Feld, L, Karpinski, W, Klein, K, Kukulies, C, Olzem, J, Ostapchuk, A, Pandoulas, D, Pierschel, G, Raupach, F, Schael, S, Schwering, G, Sprenger, D, Thomas, M, Weber, M, Wittmer, B, Wlochal, M, Beissel, F, Bock, E, Flugge, G, Gillissen, C, Hermanns, T, Heydhausen, D, Jahn, D, Kaussen, G, Linn, A, Perchalla, L, Poettgens, M, Pooth, O, Stahl, A, Zoeller, MH, Buhmann, P, Butz, E, Flucke, G, Hamdorf, R, Hauk, J, Klanner, R, Pein, U, Schleper, P, Steinbrueck, G, Bluem, P, De Boer, W, Dierlamm, A, Dirkes, G, Fahrer, M, Frey, M, Furgeri, A, Hartmann, F, Heier, S, Hoffmann, K, Kaminski, J, Ledermann, B, Liamsuwan, T, Mueller, S, Mueller, T, Schilling, F, Simonis, H, Steck, P, Zhukov, V, Cariola, P, De Robertis, G, Ferorelli, R, Fiore, L, Preda, M, Sala, G, Silvestris, L, Tempesta, P, Zito, G, Creanza, D, De Filippis, N, De Palma, M, Giordano, D, Maggi, G, Manna, N, My, S, Selvaggi, G, Albergo, S, Chiorboli, M, Costa, S, Galanti, M, Giudice, N, Guardone, N, Noto, F, Potenza, R, Saizu, MA, Sparti, V, Sutera, C, Tricomi, A, Tuve, C, Brianzi, M, Civinini, C, Maletta, F, Manolescu, F, Meschini, M, Paoletti, S, Sguazzoni, G, Broccolo, B, Ciulli, V, D'Alessandro, R, Focardi, E, Frosali, S, Genta, C, Landi, G, Lenzi, P, Macchiolo, A, Magini, N, Parrini, G, Scarlini, E, Cerati, G, Azzi, P, Bacchetta, N, Candelori, A, Dorigo, T, Kaminsky, A, Karaevski, S, Khomenkov, V, Reznikov, S, Tessaro, M, Bisello, D, De Mattia, M, Giubilato, P, Loreti, M, Mattiazzo, S, Nigro, M, Paccagnella, A, Pantano, D, Pozzobon, N, Tosi, M, Bilei, GM, Checcucci, B, Fano, L, Servoli, L, Ambroglini, F, Babucci, E, Benedetti, D, Biasini, M, Caponeri, B, Covarelli, R, Giorgi, M, Lariccia, P, Mantovani, G, Marcantonini, M, Postolache, V, Santocchia, A, Spiga, D, Bagliesi, G, Balestri, G, Berretta, L, Bianucci, S, Boccali, T, Bosi, F, Bracci, F, Castaldi, R, Ceccanti, M, Cecchi, R, Cerri, C, Cucoanes, AS, Dell'Orso, R, Dobur, D, Dutta, S, Giassi, A, Giusti, S, Kartashov, D, Kraan, A, Lomtadze, T, Lungu, GA, Magazzu, G, Mammini, P, Mariani, F, Martinelli, G, Moggi, A, Palla, F, Palmonari, F, Petragnani, G, Profeti, A, Raffaelli, F, Rizzi, D, Sanguinetti, G, Sarkar, S, Sentenac, D, Serban, AT, Slav, A, Soldani, A, Spagnolo, P, Tenchini, R, Tolaini, S, Venturi, A, Verdini, PG, Vos, M, Zaccarelli, L, Avanzini, C, Basti, A, Benucci, L, Bocci, A, Cazzola, U, Fiori, F, Linari, S, Massa, M, Messineo, A, Segneri, G, Tonelli, G, Azzurri, P, Bernardini, J, Borrello, L, Calzolari, F, Foa, L, Gennai, S, Ligabue, F, Petrucciani, G, Rizzi, A, Yang, Z, Benotto, F, Demaria, N, Dumitrache, F, Farano, R, Borgia, MA, Castello, R, Costa, M, Migliore, E, Romero, A, Abbaneo, D, Abbas, M, Ahmed, I, Akhtar, I, Albert, E, Bloch, C, Breuker, H, Butt, S, Buchmuller, O, Cattai, A, Delaere, C, Delattre, M, Edera, LM, Eppard, M, Gateau, M, Gill, K, Giolo-Nicollerat, A, Grabit, R, Honma, A, Huhtinen, M, Kloukinas, K, Kortesmaa, J, Kottelat, LJ, Leonardo, N, Ljuslin, C, Mannelli, M, Masetti, L, Marchioro, A, Mersi, S, Mirabito, L, Muffat-Joly, J, Onnela, A, Paillard, C, Pal, I, Pernot, JF, Petagna, P, Petit, P, Piccut, C, Pioppi, M, Postema, H, Ranieri, R, Ricci, D, Rolandi, G, Ronga, F, Sigaud, C, Syed, A, Siegrist, P, Tropea, P, Troska, J, Tsirou, A, Donckt, MV, Vasey, F, Alagoz, E, Amsler, C, Chiochia, V, Regenfus, C, Robmann, P, Rochet, J, Rommerskirchen, T, Schmidt, A, Steiner, S, Wilke, L, Church, I, Cole, J, Coughlan, J, Gay, A, Taghavi, S, Tomalin, I, Bainbridge, R, Cripps, N, Fulcher, J, Hall, G, Noy, M, Pesaresi, M, Radicci, V, Raymond, DM, Sharp, P, Stoye, M, Wingham, M, Zorba, O, Goitom, I, Hobson, PR, Reid, I, Teodorescu, L, Hanson, G, Jeng, G, Liu, H, Pasztor, G, Satpathy, A, Stringer, R, Mangano, B, Affolder, K, Affolder, T, Allen, A, Barge, D, Burke, S, Callahan, D, Campagnari, C, Crook, A, D'Alfonso, M, Dietch, J, Garberson, J, Hale, D, Incandela, H, Incandela, J, Jaditz, S, Kalavase, P, Kreyer, S, Kyre, S, Lamb, J, Mc Guinness, C, Mills, C, Nguyen, H, Nikolic, M, Lowette, S, Rebassoo, F, Ribnik, J, Richman, J, Rubinstein, N, Sanhueza, S, Shah, Y, Simms, L, Staszak, D, Stoner, J, Stuart, D, Swain, S, Vlimant, J, White, D, Ulmer, KA, Wagner, SR, Bagby, L, Bhat, PC, Burkett, K, Cihangir, S, Gutsche, O, Jensen, H, Johnson, M, Luzhetskiy, N, Mason, D, Miao, T, Moccia, S, Noeding, C, Ronzhin, A, Skup, E, Spalding, WJ, Spiegel, L, Tkaczyk, S, Yumiceva, F, Zatserklyaniy, A, Zerev, E, Anghel, I, Bazterra, VE, Gerber, CE, Khalatian, S, Shabalina, E, Baringer, P, Bean, A, Chen, J, Hinchey, C, Martin, C, Moulik, T, Robinson, R, Gritsan, AV, Lae, CK, Tran, NV, Everaerts, P, Hahn, KA, Harris, P, Nahn, S, Rudolph, M, Sung, K, Betchart, B, Demina, R, Gotra, Y, Korjenevski, S, Miner, D, Orbaker, D, Christofek, L, Hooper, R, Landsberg, G, Nguyen, D, Narain, M, Speer, T, and Tsang, KV
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17. Alignment of the CMS silicon strip tracker during stand-alone commissioning
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Adam, W, Bergauer, T, Dragicevic, M, Friedl, M, Fruehwirth, R, Haensel, S, Hrubec, J, Krammer, M, Oberegger, M, Pernicka, M, Schmid, S, Stark, R, Steininger, H, Uhl, D, Waltenberger, W, Widl, E, Van Mechelen, P, Cardaci, M, Beaumont, W, De Langhe, E, De Wolf, EA, Delmeire, E, Hashemi, M, Bouhali, O, Charaf, O, Clerbaux, B, Dewulf, J, Elgammal, S, Hammad, G, De Lentdecker, G, Marage, P, Velde, CV, Vanlaer, P, Wickens, J, Adler, V, Devroede, O, De Weirdt, S, D'Hondt, J, Goorens, R, Heyninck, J, Maes, J, Mozer, M, Tavernier, S, Van Lancker, L, Van Mulders, P, Villella, I, Wastiels, C, Bonnet, J, Bruno, G, De Callatay, B, Florins, B, Giammanco, A, Gregoire, G, Keutgen, T, Kcira, D, Lemaitre, V, Michotte, D, Militaru, O, Piotrzkowski, K, Quertermont, L, Roberfroid, V, Rouby, X, Teyssier, D, Daubie, E, Anttila, E, Czellar, S, Engstrom, P, Harkonen, J, Karimaki, V, Kostesmaa, J, Kuronen, A, Lampen, T, Linden, T, Luukka, P, Maenaa, T, Michal, S, Tuominen, E, Tuominiemi, J, Ageron, M, Baulieu, G, Bonnevaux, A, Boudoul, G, Chabanat, E, Chabert, E, Chierici, R, Contardo, D, Della Negra, R, Dupasquier, T, Gelin, G, Giraud, N, Guillot, G, Estre, N, Haroutunian, R, Lumb, N, Perries, S, Schirra, F, Trocme, B, Vanzetto, S, Agram, J, Blaes, R, Drouhin, F, Ernenwein, J, Fontaine, J, Berst, J, Brom, J, Didierjean, F, Goerlach, U, Graehling, P, Gross, L, Hosselet, J, Juillot, P, Lounis, A, Maazouzi, C, Olivetto, C, Strub, R, Van Hove, P, Anagnostou, G, Brauer, R, Esser, H, Feld, L, Karpinski, W, Klein, K, Kukulies, C, Olzem, J, Ostapchuk, A, Pandoulas, D, Pierschel, G, Raupach, F, Schael, S, Schwering, G, Sprenger, D, Thomas, M, Weber, M, Wittmer, B, Wlochal, M, Beissel, F, Bock, E, Flugge, G, Gillissen, C, Hermanns, T, Heydhausen, D, Jahn, D, Kaussen, G, Linn, A, Perchalla, L, Poettgens, M, Pooth, O, Stahl, A, Zoeller, MH, Buhmann, P, Butz, E, Flucke, G, Hamdorf, R, Hauk, J, Klanner, R, Pein, U, Schleper, P, Steinbrueck, G, Bluem, P, De Boer, W, Dierlamm, A, Dirkes, G, Fahrer, M, Frey, M, Furgeri, A, Hartmann, F, Heier, S, Hoffmann, K, Kaminski, J, Ledermann, B, Liamsuwan, T, Mueller, S, Mueller, T, Schilling, F, Simonis, H, Steck, P, Zhukov, V, Cariola, P, De Robertis, G, Ferorelli, R, Fiore, L, Preda, M, Sala, G, Silvestris, L, Tempesta, P, Zito, G, Creanza, D, De Filippis, N, De Palma, M, Giordano, D, Maggi, G, Manna, N, My, S, Selvaggi, G, Albergo, S, Chiorboli, M, Costa, S, Galanti, M, Giudice, N, Guardone, N, Noto, F, Potenza, R, Saizu, MA, Sparti, V, Sutera, C, Tricomi, A, Tuve, C, Brianzi, M, Civinini, C, Maletta, F, Manolescu, F, Meschini, M, Paoletti, S, Sguazzoni, G, Broccolo, B, Ciulli, V, Focardi, RDE, Frosali, S, Genta, C, Landi, G, Lenzi, P, Macchiolo, A, Magini, N, Parrini, G, Scarlini, E, Cerati, G, Azzi, P, Bacchetta, N, Candelori, A, Dorigo, T, Kaminsky, A, Karaevski, S, Khomenkov, V, Reznikov, S, Tessaro, M, Bisello, D, De Mattia, M, Giubilato, P, Loreti, M, Mattiazzo, S, Nigro, M, Paccagnella, A, Pantano, D, Pozzobon, N, Tosi, M, Bilei, GM, Checcucci, B, Fano, L, Servoli, L, Ambroglini, F, Babucci, E, Benedetti, D, Biasini, M, Caponeri, B, Covarelli, R, Giorgi, M, Lariccia, P, Mantovani, G, Marcantonini, M, Postolache, V, Santocchia, A, Spiga, D, Bagliesi, G, Balestri, G, Berretta, L, Bianucci, S, Boccali, T, Bosi, F, Bracci, F, Castaldi, R, Ceccanti, M, Cecchi, R, Cerri, C, Cucoanes, AS, Dell'Orso, R, Dobur, D, Dutta, S, Giassi, A, Giusti, S, Kartashov, D, Kraan, A, Lomtadze, T, Lungu, GA, Magazzu, G, Mammini, P, Mariani, F, Martinelli, G, Moggi, A, Palla, F, Palmonari, F, Petragnani, G, Profeti, A, Raffaelli, F, Rizzi, D, Sanguinetti, G, Sarkar, S, Sentenac, D, Serban, AT, Slav, A, Soldani, A, Spagnolo, P, Tenchini, R, Tolaini, S, Venturi, A, Verdini, PG, Vos, M, Zaccarelli, L, Avanzini, C, Basti, A, Benucci, L, Bocci, A, Cazzola, U, Fiori, F, Linari, S, Massa, M, Messineo, A, Segneri, G, Tonelli, G, Azzurri, P, Bernardini, J, Borrello, L, Calzolari, F, Foa, L, Gennai, S, Ligabue, F, Petrucciani, G, Rizzi, A, Yang, Z, Benotto, F, Demaria, N, Dumitrache, F, Farano, R, Borgia, MA, Castello, R, Costa, M, Migliore, E, Romero, A, Abbaneo, D, Abbas, M, Ahmed, I, Akhtar, I, Albert, E, Bloch, C, Breuker, H, Butt, S, Buchmuller, O, Cattai, A, Delaere, C, Delattre, M, Edera, LM, Eppard, M, Gateau, M, Gill, K, Giolo-Nicollerat, A, Grabit, R, Honma, A, Huhtinen, M, Kloukinas, K, Kortesmaa, J, Kottelat, LJ, Leonardo, N, Ljuslin, C, Mannelli, M, Masetti, L, Marchioro, A, Mersi, S, Mirabito, L, Muffat-Joly, J, Onnela, A, Paillard, C, Pal, I, Pernot, JF, Petagna, P, Petit, P, Piccut, C, Pioppi, M, Postema, H, Ranieri, R, Ricci, D, Rolandi, G, Ronga, F, Sigaud, C, Syed, A, Siegrist, P, Tropea, P, Troska, J, Tsirou, A, Donckt, MV, Vasey, F, Alagoz, E, Amsler, C, Chiochia, V, Regenfus, C, Robmann, P, Rochet, J, Rommerskirchen, T, Schmidt, A, Steiner, S, Wilke, L, Church, I, Cole, J, Coughlan, J, Gay, A, Taghavi, S, Tomalin, I, Bainbridge, R, Cripps, N, Fulcher, J, Hall, G, Noy, M, Pesaresi, M, Radicci, V, Raymond, DM, Sharp, P, Stoye, M, Wingham, M, Zorba, O, Goitom, I, Hobson, PR, Reid, I, Teodorescu, L, Hanson, G, Jeng, G, Liu, H, Pasztor, G, Satpathy, A, Stringer, R, Mangano, B, Affolder, K, Affolder, T, Allen, A, Barge, D, Burke, S, Callahan, D, Campagnari, C, Crook, A, D'Alfonso, M, Dietch, J, Garberson, J, Hale, D, Incandela, H, Incandela, J, Jaditz, S, Kalavase, P, Kreyer, S, Kyre, S, Lamb, J, Mc Guinness, C, Mills, C, Nguyen, H, Nikolic, M, Lowette, S, Rebassoo, F, Ribnik, J, Richman, J, Rubinstein, N, Sanhueza, S, Shah, Y, Simms, L, Staszak, D, Stoner, J, Stuart, D, Swain, S, Vlimant, J, White, D, Ulmer, KA, Wagner, SR, Bagby, L, Bhat, PC, Burkett, K, Cihangir, S, Gutsche, O, Jensen, H, Johnson, M, Luzhetskiy, N, Mason, D, Miao, T, Moccia, S, Noeding, C, Ronzhin, A, Skup, E, Spalding, WJ, Spiegel, L, Tkaczyk, S, Yumiceva, F, Zatserklyaniy, A, Zerev, E, Anghel, I, Bazterra, VE, Gerber, CE, Khalatian, S, Shabalina, E, Baringer, P, Bean, A, Chen, J, Hinchey, C, Martin, C, Moulik, T, Robinson, R, Gritsan, AV, Lae, CK, Tran, NV, Everaerts, P, Hahn, KA, Harris, P, Nahn, S, Rudolph, M, Sung, K, Betchart, B, Demina, R, Gotra, Y, Korjenevski, S, Miner, D, Orbaker, D, Christofek, L, Hooper, R, Landsberg, G, Nguyen, D, Narain, M, Speer, T, Tsang, KV, Adam, W, Bergauer, T, Dragicevic, M, Friedl, M, Fruehwirth, R, Haensel, S, Hrubec, J, Krammer, M, Oberegger, M, Pernicka, M, Schmid, S, Stark, R, Steininger, H, Uhl, D, Waltenberger, W, Widl, E, Van Mechelen, P, Cardaci, M, Beaumont, W, De Langhe, E, De Wolf, EA, Delmeire, E, Hashemi, M, Bouhali, O, Charaf, O, Clerbaux, B, Dewulf, J, Elgammal, S, Hammad, G, De Lentdecker, G, Marage, P, Velde, CV, Vanlaer, P, Wickens, J, Adler, V, Devroede, O, De Weirdt, S, D'Hondt, J, Goorens, R, Heyninck, J, Maes, J, Mozer, M, Tavernier, S, Van Lancker, L, Van Mulders, P, Villella, I, Wastiels, C, Bonnet, J, Bruno, G, De Callatay, B, Florins, B, Giammanco, A, Gregoire, G, Keutgen, T, Kcira, D, Lemaitre, V, Michotte, D, Militaru, O, Piotrzkowski, K, Quertermont, L, Roberfroid, V, Rouby, X, Teyssier, D, Daubie, E, Anttila, E, Czellar, S, Engstrom, P, Harkonen, J, Karimaki, V, Kostesmaa, J, Kuronen, A, Lampen, T, Linden, T, Luukka, P, Maenaa, T, Michal, S, Tuominen, E, Tuominiemi, J, Ageron, M, Baulieu, G, Bonnevaux, A, Boudoul, G, Chabanat, E, Chabert, E, Chierici, R, Contardo, D, Della Negra, R, Dupasquier, T, Gelin, G, Giraud, N, Guillot, G, Estre, N, Haroutunian, R, Lumb, N, Perries, S, Schirra, F, Trocme, B, Vanzetto, S, Agram, J, Blaes, R, Drouhin, F, Ernenwein, J, Fontaine, J, Berst, J, Brom, J, Didierjean, F, Goerlach, U, Graehling, P, Gross, L, Hosselet, J, Juillot, P, Lounis, A, Maazouzi, C, Olivetto, C, Strub, R, Van Hove, P, Anagnostou, G, Brauer, R, Esser, H, Feld, L, Karpinski, W, Klein, K, Kukulies, C, Olzem, J, Ostapchuk, A, Pandoulas, D, Pierschel, G, Raupach, F, Schael, S, Schwering, G, Sprenger, D, Thomas, M, Weber, M, Wittmer, B, Wlochal, M, Beissel, F, Bock, E, Flugge, G, Gillissen, C, Hermanns, T, Heydhausen, D, Jahn, D, Kaussen, G, Linn, A, Perchalla, L, Poettgens, M, Pooth, O, Stahl, A, Zoeller, MH, Buhmann, P, Butz, E, Flucke, G, Hamdorf, R, Hauk, J, Klanner, R, Pein, U, Schleper, P, Steinbrueck, G, Bluem, P, De Boer, W, Dierlamm, A, Dirkes, G, Fahrer, M, Frey, M, Furgeri, A, Hartmann, F, Heier, S, Hoffmann, K, Kaminski, J, Ledermann, B, Liamsuwan, T, Mueller, S, Mueller, T, Schilling, F, Simonis, H, Steck, P, Zhukov, V, Cariola, P, De Robertis, G, Ferorelli, R, Fiore, L, Preda, M, Sala, G, Silvestris, L, Tempesta, P, Zito, G, Creanza, D, De Filippis, N, De Palma, M, Giordano, D, Maggi, G, Manna, N, My, S, Selvaggi, G, Albergo, S, Chiorboli, M, Costa, S, Galanti, M, Giudice, N, Guardone, N, Noto, F, Potenza, R, Saizu, MA, Sparti, V, Sutera, C, Tricomi, A, Tuve, C, Brianzi, M, Civinini, C, Maletta, F, Manolescu, F, Meschini, M, Paoletti, S, Sguazzoni, G, Broccolo, B, Ciulli, V, Focardi, RDE, Frosali, S, Genta, C, Landi, G, Lenzi, P, Macchiolo, A, Magini, N, Parrini, G, Scarlini, E, Cerati, G, Azzi, P, Bacchetta, N, Candelori, A, Dorigo, T, Kaminsky, A, Karaevski, S, Khomenkov, V, Reznikov, S, Tessaro, M, Bisello, D, De Mattia, M, Giubilato, P, Loreti, M, Mattiazzo, S, Nigro, M, Paccagnella, A, Pantano, D, Pozzobon, N, Tosi, M, Bilei, GM, Checcucci, B, Fano, L, Servoli, L, Ambroglini, F, Babucci, E, Benedetti, D, Biasini, M, Caponeri, B, Covarelli, R, Giorgi, M, Lariccia, P, Mantovani, G, Marcantonini, M, Postolache, V, Santocchia, A, Spiga, D, Bagliesi, G, Balestri, G, Berretta, L, Bianucci, S, Boccali, T, Bosi, F, Bracci, F, Castaldi, R, Ceccanti, M, Cecchi, R, Cerri, C, Cucoanes, AS, Dell'Orso, R, Dobur, D, Dutta, S, Giassi, A, Giusti, S, Kartashov, D, Kraan, A, Lomtadze, T, Lungu, GA, Magazzu, G, Mammini, P, Mariani, F, Martinelli, G, Moggi, A, Palla, F, Palmonari, F, Petragnani, G, Profeti, A, Raffaelli, F, Rizzi, D, Sanguinetti, G, Sarkar, S, Sentenac, D, Serban, AT, Slav, A, Soldani, A, Spagnolo, P, Tenchini, R, Tolaini, S, Venturi, A, Verdini, PG, Vos, M, Zaccarelli, L, Avanzini, C, Basti, A, Benucci, L, Bocci, A, Cazzola, U, Fiori, F, Linari, S, Massa, M, Messineo, A, Segneri, G, Tonelli, G, Azzurri, P, Bernardini, J, Borrello, L, Calzolari, F, Foa, L, Gennai, S, Ligabue, F, Petrucciani, G, Rizzi, A, Yang, Z, Benotto, F, Demaria, N, Dumitrache, F, Farano, R, Borgia, MA, Castello, R, Costa, M, Migliore, E, Romero, A, Abbaneo, D, Abbas, M, Ahmed, I, Akhtar, I, Albert, E, Bloch, C, Breuker, H, Butt, S, Buchmuller, O, Cattai, A, Delaere, C, Delattre, M, Edera, LM, Eppard, M, Gateau, M, Gill, K, Giolo-Nicollerat, A, Grabit, R, Honma, A, Huhtinen, M, Kloukinas, K, Kortesmaa, J, Kottelat, LJ, Leonardo, N, Ljuslin, C, Mannelli, M, Masetti, L, Marchioro, A, Mersi, S, Mirabito, L, Muffat-Joly, J, Onnela, A, Paillard, C, Pal, I, Pernot, JF, Petagna, P, Petit, P, Piccut, C, Pioppi, M, Postema, H, Ranieri, R, Ricci, D, Rolandi, G, Ronga, F, Sigaud, C, Syed, A, Siegrist, P, Tropea, P, Troska, J, Tsirou, A, Donckt, MV, Vasey, F, Alagoz, E, Amsler, C, 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Moccia, S, Noeding, C, Ronzhin, A, Skup, E, Spalding, WJ, Spiegel, L, Tkaczyk, S, Yumiceva, F, Zatserklyaniy, A, Zerev, E, Anghel, I, Bazterra, VE, Gerber, CE, Khalatian, S, Shabalina, E, Baringer, P, Bean, A, Chen, J, Hinchey, C, Martin, C, Moulik, T, Robinson, R, Gritsan, AV, Lae, CK, Tran, NV, Everaerts, P, Hahn, KA, Harris, P, Nahn, S, Rudolph, M, Sung, K, Betchart, B, Demina, R, Gotra, Y, Korjenevski, S, Miner, D, Orbaker, D, Christofek, L, Hooper, R, Landsberg, G, Nguyen, D, Narain, M, Speer, T, and Tsang, KV
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18. (565) - Role of Acquired Von Willebrand Syndrome in the Development of Bleeding Complications in Patients Treated Using Right Ventricular Microaxial Flow Pump Devices: A Retrospective Cohort Study.
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Oezkur, M., Reda, S., Rühl, H., Nils, T., Kreyer, S., Duerr, G.D., Charitos, E., Medina, M., Zimmer, S., Putensen, C., and Treede, H.
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VON Willebrand disease , *COHORT analysis , *HEART assist devices , *HEMORRHAGE , *RETROSPECTIVE studies - Published
- 2024
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19. Modular extracorporeal life support: effects of ultrafiltrate recirculation on the performance of an extracorporeal carbon dioxide removal device
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Vittorio Scaravilli, Antonio Pesenti, Alberto Zanella, Slava Belenkiy, Stefan Kreyer, Leopoldo C. Cancio, Kevin K. Chung, Katharina Linden, Jeremy W. Cannon, Andriy I. Batchinsky, Bryan S. Jordan, Scaravilli, V, Kreyer, S, Linden, K, Belenkiy, S, Jordan, B, Pesenti, A, Zanella, A, Chung, K, Cannon, J, Cancio, L, and Batchinsky, A
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Extracorporeal Circulation ,Time Factors ,Respiratory rate ,medicine.medical_treatment ,Biomedical Engineering ,Biophysics ,Hemodynamics ,Bioengineering ,Extracorporeal ,Biomaterials ,Extracorporeal Membrane Oxygenation ,Heart Rate ,Hemofiltration ,medicine ,Animals ,Chromatography ,Sheep ,Chemistry ,General Medicine ,Blood flow ,Equipment Design ,Carbon Dioxide ,Respiration, Artificial ,Breathing ,Arterial blood ,Fluid Therapy ,Female ,extradorporeal circulation, CO2 ,Blood Gas Analysis ,Respiratory Insufficiency ,Respiratory minute volume - Abstract
The combination of extracorporeal carbon dioxide removal (ECCO2R) and hemofiltration is a possible therapeutic strategy for patients needing both lung and renal support. We tested the effects of the recirculation of ultrafiltrate on membrane lung (ML) CO2 removal (VCO2ML). Three conscious, spontaneously breathing sheep were connected to a commercially produced ECCO2R device (Hemolung; Alung Technologies, Pittsburgh, PA) with a blood flow of 250 ml/min and a gas flow of 10 L/min. A hemofilter (NxStage, NxStage Medical, Lawrence, MA) was interposed in series after the ML. Ultrafiltrate flow was generated and recirculated before the ML. We tested four ultrafiltrate flows (0, 50, 100, and 150 ml/min) for 25 min each, eight times per animal, resulting in 24 randomized test repetitions. We recorded VCO2ML, hemodynamics and ventilatory variables, and natural lung CO2 transfer (VCO2NL) and collected arterial and circuitry blood samples. VCO2ML was unchanged by application of ultrafiltrate recirculation (40.5 ± 4.0, 39.7 ± 4.2, 39.8 ± 4.2, and 39.2 ± 4.1 ml/min, respectively, at ultrafiltrate flow of 0, 50, 100, and 150 ml/min). Minute ventilation, respiratory rate, VCO2NL, and arterial blood analyses were not affected by ultrafiltrate recirculation. In the tested configuration, ultrafiltrate recirculation did not affect VCO2ML. This modular technology may provide a suitable platform for coupling CO2 removal with various forms of blood purification.
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- 2014
20. Performance studies of the CMS Strip Tracker before installation
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Roberto Castello, P. Siegrist, Sukanta Dutta, A. Syed, J. Rochet, Pierre Marage, C. Mc Guinness, L. Quertermont, A. Bonnevaux, M. Galanti, S. Butt, Renato Potenza, M. Nigro, R. Brauer, A. Zatserklyaniy, Boris Mangano, Fabrizio Palla, C. Maazouzi, A. C. Kraan, A. Profeti, Kevin Burkett, M. Costa, Dario Bisello, Ariella Cattai, Frank Hartmann, Alin Titus Serban, Laura Borrello, V. Roberfroid, S. Steiner, P. Van Mechelen, Frederic Jean Ronga, Filippo Bosi, Jean-Laurent Agram, P. Sharp, Michael Wlochal, M. Cardaci, A. Linn, F. Maletta, Otilia Militaru, P. Cariola, M. Ceccanti, Donato Creanza, E. Skup, A. Satpathy, S. Schmid, Corrinne Mills, R. Stark, T. Affolder, J. Heyninck, Duong Nguyen, J. Lamb, Volker Adler, N. Luzhetskiy, E. Anttila, G. Martinelli, G. Guillot, G. De Robertis, D. Uhl, Nuno Leonardo, N. Estre, L. Simms, C. Avanzini, M. Wingham, R. Hamdorf, V. Radicci, T. Boccali, Christopher Martin, Josef Hrubec, E. A. De Wolf, J. L. Bonnet, C. Regenfus, Stephen Robert Wagner, A. Basti, S. Schael, Jorgen D'Hondt, Krzysztof Piotrzkowski, Geoffrey Hall, Finn Rebassoo, Guido Tonelli, Sebastiano Albergo, C. Cerri, D. Pandoulas, S. Hänsel, Pascal Vanlaer, Frank Raupach, Salvatore My, S. Reznikov, S. Linari, Othmane Bouhali, David Mason, F. Calzolari, Joe Incandela, W. Beaumont, Wolfgang Waltenberger, Ghislain Grégoire, Piergiulio Lenzi, Th. Hermanns, G. Maggi, Maurizio Biasini, C. Genta, Henrik Jeldtoft Jensen, R. Hooper, K. V. Tsang, B. Checcucci, Simone Gennai, Burton Betchart, A. Kuronen, N. De Filippis, L. Perchalla, T. Rommerskirchen, L. Zaccarelli, S. Kreyer, M. Pernicka, J. Chen, A. Furgeri, G. Magazzu, F. Manolescu, H. Postema, Devis Pantano, Teimuraz Lomtadze, M. Eppard, G. Gelin, S. Korjenevski, Nicola Pozzobon, I. Pal, R. Frühwirth, Max Weber, Alessandro Paccagnella, A. Onnela, N. Lumb, Matthew Scott Rudolph, P. Blüm, Mia Tosi, M. De Mattia, Y. Gotra, E. Delmeire, G. Segneri, Giuseppe Zito, Y. Shah, F. Didierjean, D. Benedetti, Olivier Devroede, Giovanni Petrucciani, Achim Stahl, F. Ambroglini, I. M. Anghel, Ettore Focardi, Gordon H. Hanson, Leonard Spiegel, Nicola Bacchetta, F. Dumitrache, S. Elgammal, M. Preda, Jonathan Fulcher, Tapio Lampén, L. Berretta, Dieter Jahn, C. Hinchey, Tommaso Dorigo, Markus Friedl, C. Ljuslin, Oliver Gutsche, T. Moulik, Horst Breuker, Lutz Feld, G. Baulieu, C. Sigaud, N. Rubinstein, T. Dupasquier, M. Fahrer, G. A. Lungu, Panja-Riina Luukka, M. Loreti, Robert Klanner, G. Dirkes, D. Heydhausen, Kristian Allan Hahn, I. Villella, Andrey Ostapchuk, Livio Fanò, D. Rizzi, P. Steck, L. Masetti, Ivan Reid, Ijaz Ahmed, A. S. Giolo-Nicollerat, S. Burke, K. Affolder, S. Moccia, Stefano Mersi, S. Tkaczyk, David Stuart, A. Moggi, Peter Schleper, S. Michal, Keith Ulmer, Philip Baringer, Jorma Tuominiemi, Piero Giorgio Verdini, Nicholas Cripps, Pierre Juillot, S. Cihangir, N. Giudice, Alexander Schmidt, Th. Müller, T. Speer, Gabriele Balestri, Gero Flucke, E. Bock, V. E. Bazterra, J. D. Richman, John A Coughlan, R. Stringer, C. Noeding, L. Benucci, M. De Palma, Daniel E. Hale, D. Ricci, F. Mariani, Veikko Karimäki, Oliver Pooth, M. Giorgi, C. Kukulies, Gaelle Boudoul, Gian Mario Bilei, G. De Lentdecker, Alexander Dierlamm, Lorenzo Foà, Otman Charaf, Roberto Dell'Orso, L. Kottelat, Roberto Chierici, Giancarlo Mantovani, Oliver Buchmuller, N. Magini, G. Bagliesi, J. Olzem, Vincent Lemaitre, A. Kaminsky, D. Michotte, G. Sala, M. Marcantonini, Piero Giubilato, J. Kostesmaa, T. Lindén, Jochen Kaminski, E. Butz, Georg Steinbrück, F. Raffaelli, M. A. Saizu, R. Ranieri, G. Kaussen, Barbara Clerbaux, M. Brianzi, Georgios Anagnostou, S. Giusti, Nhan Viet Tran, Jan Troska, Robert Bainbridge, Claude Amsler, Peter R Hobson, Domenico Giordano, M. Massa, Cristina Tuve, E. Zerev, Alberto Messineo, B. Trocme, John H. Wickens, Jean-Marie Brom, Meenakshi Narain, C. Vander Velde, M. Noy, J. Ribnik, Mark Pesaresi, H. Incandela, Alessia Tricomi, R. Robinson, S. Heier, I. Goitom, O. Zorba, A. Macchiolo, A. S. Cucoanes, D. Callahan, F. Drouhin, A. Crook, Philip Harris, U. Pein, Jaakko Härkönen, M. A. Borgia, Vitaliano Ciulli, Paolo Azzurri, U. Cazzola, P. Buhmann, Ulrich Goerlach, N. Guardone, L. Teodorescu, Elizaveta Shabalina, D. Kartashov, S. Taghavi, P. Van Hove, S. Vanzetto, Duccio Abbaneo, Andrea Rizzi, M. Oberegger, A. K. Honma, S. Frosali, C. Wastiels, I. Church, R. Strub, Eric Christian Chabert, C. Olivetto, A. Bocci, A. Candelori, Andrea Venturi, Rino Castaldi, Th. Keutgen, Valery Zhukov, Steve Nahn, Marco Meschini, R. Grabit, M. Gateau, Mariarosaria D'Alfonso, S. De Weirdt, S. Müller, D. Kcira, C. Bloch, X. Rouby, Alice Bean, Katja Klein, D. Sentenac, Derek Barge, E. Widl, B. Broccolo, Laurent Mirabito, J. Dietch, Steven Lowette, J. Hosselet, Regina Demina, Sandor Czellar, D. White, Johannes Hauk, Paolo Petagna, Serena Mattiazzo, G. Pierschel, Z. C. Yang, Peter Robmann, Paolo Spagnolo, B. Florins, Daniel Teyssier, Jean-Charles Fontaine, Andromachi Tsirou, A. Marchioro, Francisco Yumiceva, Karl Heinz Hoffmann, M. Thomas, A. Ronzhin, Attilio Santocchia, M. Frey, I. Akhtar, Francois Vasey, Karl Gill, M. Delattre, Marko Dragicevic, J. Stoner, C. K. Lae, V. Postolache, Geng-Yuan Jeng, H. Esser, F. Noto, D. Sprenger, Natale Demaria, J.D. Berst, Marvin Johnson, P. Van Mulders, M. Pioppi, Ernesto Migliore, Hans-Jürgen Simonis, G. Petragnani, Andrea Giammanco, S. Sanhueza, Gregory Habib Hammad, J. F. Pernot, H. Liu, Jean-Roch Vlimant, J. Muffat-Joly, G. Schwering, P. Tropea, Stefaan Tavernier, W. De Boer, Luigi Fiore, Cecilia Elena Gerber, M. H. Zoeller, Roberto Covarelli, Ian R Tomalin, P. Tempesta, J. P. Ernenwein, D. Orbaker, B. Ledermann, R. Farano, A. Soldani, R. Goorens, J. P Dewulf, G. Sanguinetti, E. Scarlini, S. Swain, Didier Contardo, S. Kyre, William J Spalding, Salvatore Costa, D. C. Miner, G. Parrini, E. De Langhe, L. Van Lancker, B. Caponeri, J. Kortesmaa, E. Babucci, Didar Dobur, F. Schirra, Paolo Lariccia, M. Ageron, N. Manna, S. Bianucci, Manfred Krammer, T. Miao, Kevin Sung, Thomas Bergauer, Roberto Cecchi, P Petit, Vincenzo Chiochia, Claudio Campagnari, Teppo Mäenpää, Mika Huhtinen, F. Benotto, C. Piccut, C. Paillard, R. Della Negra, Abdenour Lounis, M. Poettgens, A. Slav, L. Christofek, L. M. Edera, Bruno Wittmer, Joris Maes, Lucia Silvestris, Franco Ligabue, M. Vander Donckt, M. Tessaro, Joanne Cole, F. Bracci, Hien Nguyen, Eija Tuominen, L. Wilke, Roberto Tenchini, Pieter Everaerts, P. Graehling, T. Liamsuwan, Marcel Vos, S. Jaditz, R. Haroutunian, G. Landi, Simone Paoletti, Greg Landsberg, E. Daubie, D. Staszak, M. Nikolic, P. Mammini, H. Steininger, Francesco Fiori, F. P. Schilling, R. Ferorelli, Eric Chabanat, L. Gross, Stephane Perries, Raffaello D'Alessandro, F. Beissel, Gabriella Pasztor, S. Karaevski, Matthias Ulrich Mozer, Massimiliano Chiorboli, Giovanna Selvaggi, Günter Flügge, Wolfgang Adam, Patrizia Azzi, N. Giraud, P. Kalavase, Andrei Gritsan, S. Khalatian, Markus Stoye, E. Alagoz, V. Sparti, L. Servoli, Carlo Civinini, J. Garberson, Shreya Sarkar, E. Albert, Giacomo Sguazzoni, P. Engström, S. Tolaini, Alessandra Romero, Waclaw Karpinski, Alessandro Giassi, M. Abbas, Pushpalatha C Bhat, Gigi Rolandi, C. Gillissen, V. Khomenkov, Marcello Mannelli, C. M. Sutera, F. Palmonari, David Mark Raymond, Christophe Delaere, Giuseppe Benedetto Cerati, Kostas Kloukinas, A. Allen, Daniele Spiga, M. Hashemi, Giacomo Bruno, L. Bagby, R. Blaes, B. De Callatay, Jacopo Bernardini, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), informatique, Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Groupe de Recherche en Physique des Hautes Energies (GRPHE), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), European Organization for Nuclear Research (CERN), CMS, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Adam, W., Bergauer, T., Dragicevic, M., Friedl, M., Fruehwirth, R., Haensel, S., Hrubec, J., Krammer, M., Oberegger, M., Pernicka, M., Schmid, S., Stark, R., Steininger, H., Uhl, D., Waltenberger, W., Widl, E., Van Mechelen, P., Cardaci, M., Beaumont, W., de Langhe, E., de Wolf, E. A., Delmeire, E., Hashemi, M., Bouhali, O., Charaf, O., Clerbaux, B., Dewulf, J. P., Elgammal, S., Hammad, G., de Lentdecker, G., Marage, P., Velde C., Vander, Vanlaer, P., Wickens, J., Adler, V., Devroede, O., De Weirdt, S., D'Hondt, J., Goorens, R., Heyninck, J., Maes, J., Mozer, M., Tavernier, S., Van Lancker, L., Van Mulders, P., Villella, I., Wastiels, C., Bonnet, J. L., Bruno, G., De Callatay, B., Florins, B., Giammanco, A., Gregoire, G., Keutgen, T. h., Kcira, D., Lemaitre, V., Michotte, D., Militaru, O., Piotrzkowski, K., Quertermont, L., Roberfroid, V., Rouby, X., Teyssier, D., Daubie, E., Anttila, E., Czellar, S., Engstrom, P., Harkonen, J., Karimaki, V., Kostesmaa, J., Kuronen, A., Lampen, T., Linden, T., Luukka, P. R., Maenpaa, T., Michal, S., Tuominen, E., Tuominiemi, J., Ageron, M., Baulieu, G., Bonnevaux, A., Boudoul, G., Chabanat, E., Chabert, E., Chierici, R., Contardo, D., Della Negra, R., Dupasquier, T., Gelin, G., Giraud, N., Guillot, G., Estre, N., Haroutunian, R., Lumb, N., Perries, S., Schirra, F., Trocme, B., Vanzetto, S., Agram, J. L., Blaes, R., Drouhin, F., Ernenwein, J. P., Fontaine, J. C., Berst, J. D., Brom, J. M., Didierjean, F., Goerlach, U., Graehling, P., Gross, L., Hosselet, J., Juillot, P., Lounis, A., Maazouzi, C., Olivetto, C., Strub, R., Van Hove, P., Anagnostou, G., Brauer, R., Esser, H., Feld, L., Karpinski, W., Klein, K., Kukulies, C., Olzem, J., Ostapchuk, A., Pandoulas, D., Pierschel, G., Raupach, F., Schael, S., Schwering, G., Sprenger, D., Thomas, M., Weber, M., Wittmer, B., Wlochal, M., Beissel, F., Bock, E., Flugge, G., Gillissen, C., Hermanns, T., Heydhausen, D., Jahn, D., Kaussen, G., Linn, A., Perchalla, L., Poettgens, M., Pooth, O., Stahl, A., Zoeller, M. H., Buhmann, P., Butz, E., Flucke, G., Hamdorf, R., Hauk, J., Klanner, R., Pein, U., Schleper, P., Steinbrueck, G., Bluem, P., De Boer, W., Dierlamm, A., Dirkes, G., Fahrer, M., Frey, M., Furgeri, A., Hartmann, F., Heier, S., Hoffmann, K. H., Kaminski, J., Ledermann, B., Liamsuwan, T., Mueller, S., Mueller, T. h., Schilling, F. P., Simonis, H. J., Steck, P., Zhukov, V., Cariola, P., De Robertis, G., Ferorelli, R., Fiore, L., Preda, M., Sala, G., Silvestris, L., Tempesta, P., Zito, G., Creanza, D., De Filippis, N., De Palma, M., Giordano, D., Maggi, G., Manna, N., My, S., Selvaggi, G., Albergo, S., Chiorboli, M., Costa, S., Galanti, M., Giudice, N., Guardone, N., Noto, F., Potenza, R., Saizu, M. A., Sparti, V., Sutera, C., Tricomi, A., Tuve, C., Brianzi, M., Civinini, C., Maletta, F., Manolescu, F., Meschini, M., Paoletti, S., Sguazzoni, G., Broccolo, B., Ciulli, V., D'Alessandro, R., Focardi, E., Frosali, S., Genta, C., Landi, G., Lenzi, P., Macchiolo, A., Magini, N., Parrini, G., Scarlini, E., Cerati, G., Azzi, P., Bacchetta, N., Candelori, A., Dorigo, T., Kaminsky, A., Karaevski, S., Khomenkov, V., Reznikov, S., Tessaro, M., Bisello, D., De Mattia, M., Giubilato, P., Loreti, M., Mattiazzo, S., Nigro, M., Paccagnella, A., Pantano, D., Pozzobon, N., Tosi, M., Bilei, G. M., Checcucci, B., Fano, L., Servoli, L., Ambroglini, F., Babucci, E., Benedetti, D., Biasini, M., Caponeri, B., Covarelli, R., Giorgi, M., Lariccia, P., Mantovani, G., Marcantonini, M., Postolache, V., Santocchia, A., Spiga, D., Bagliesi, G., Balestri, G., Berretta, L., Bianucci, S., Boccali, T., Bosi, F., Bracci, F., Castaldi, R., Ceccanti, M., Cecchi, R., Cerri, C., Cucoanes, A. S., Dell'Orso, R., Dobur, D., Dutta, S., Giassi, A., Giusti, S., Kartashov, D., Kraan, A., Lomtadze, T., Lungu, G. A., Magazzu, G., Mammini, P., Mariani, F., Martinelli, G., Moggi, A., Palla, F., Palmonari, F., Petragnani, G., Profeti, A., Raffaelli, F., Rizzi, D., Sanguinetti, G., Sarkar, S., Sentenac, D., Serban, A. T., Slav, A., Soldani, A., Spagnolo, P., Tenchini, R., Tolaini, S., Venturi, A., Verdini, P. G., Vos, M., Zaccarelli, L., Avanzini, C., Basti, A., Benucci, L., Bocci, A., Cazzola, U., Fiori, F., Linari, S., Massa, M., Messineo, A., Segneri, G., Tonelli, G., Azzurri, P., Bernardini, J., Borrello, L., Calzolari, Federico, Foa, L., Gennai, S., Ligabue, Franco, Petrucciani, G., Rizzi, A., Yang, Z., Benotto, F., Demaria, N., Dumitrache, F., Farano, R., Borgia, M. A., Castello, R., Costa, M., Migliore, E., Romero, A., Abbaneo, D., Abbas, M., Ahmed, I., Akhtar, I., Albert, E., Bloch, C., Breuker, H., Butt, S., Buchmuller, O., Cattai, A., Delaere, C., Delattre, M., Edera, L. M., Eppard, M., Gateau, M., Gill, K., Giolo Nicollerat, A. S., Grabit, R., Honma, A., Huhtinen, M., Kloukinas, K., Kortesmaa, J., Kottelat, L. J., Leonardo, N., Ljuslin, C., Mannelli, M., Masetti, L., Marchioro, A., Mersi, S., Mirabito, L., Muffat Joly, J., Onnela, A., Paillard, C., Pal, I., Pernot, J. F., Petagna, P., Petit, P., Piccut, C., Pioppi, M., Postema, H., Ranieri, R., Ricci, D., Rolandi, Luigi, Ronga, F., Sigaud, C., Syed, A., Siegrist, P., Tropea, P., Troska, J., Tsirou, A., Donckt M., Vander, Vasey, F., Alagoz, E., Amsler, C., Chiochia, V., Regenfus, C., Robmann, P., Rochet, J., Rommerskirchen, T., Schmidt, A., Steiner, S., Wilke, L., Church, I., Cole, J., Coughlan, J., Gay, A., Taghavi, S., Tomalin, I., Bainbridge, R., Cripps, N., Fulcher, J., Hall, G., Noy, M., Pesaresi, M., Radicci, V., Raymond, D. M., Sharp, P., Stoye, M., Wingham, M., Zorba, O., Goitom, I., Hobson, P. R., Reid, I., Teodorescu, L., Hanson, G., Jeng, G. Y., Liu, H., Pasztor, G., Satpathy, A., Stringer, R., Mangano, B., Affolder, K., Affolder, T., Allen, A., Barge, D., Burke, S., Callahan, D., Campagnari, C., Crook, A., D'Alfonso, M., Dietch, J., Garberson, J., Hale, D., Incandela, H., Incandela, J., Jaditz, S., Kalavase, P., Kreyer, S., Kyre, S., Lamb, J., Mc Guinness, C., Mills, C., Nguyen, H., Nikolic, M., Lowette, S., Rebassoo, F., Ribnik, J., Richman, J., Rubinstein, N., Sanhueza, S., Shah, Y., Simms, L., Staszak, D., Stoner, J., Stuart, D., Swain, S., Vlimant, J. R., White, D., Ulmer, K. A., Wagner, S. R., Bagby, L., Bhat, P. C., Burkett, K., Cihangir, S., Gutsche, O., Jensen, H., Johnson, M., Luzhetskiy, N., Mason, D., Miao, T., Moccia, S., Noeding, C., Ronzhin, A., Skup, E., Spalding, W. J., Spiegel, L., Tkaczyk, S., Yumiceva, F., Zatserklyaniy, A., Zerev, E., Anghel, I., Bazterra, V. E., Gerber, C. E., Khalatian, S., Shabalina, E., Baringer, P., Bean, A., Chen, J., Hinchey, C., Martin, C., Moulik, T., Robinson, R., Gritsan, A. V., Lae, C. K., Tran, N. V., Everaerts, P., Hahn, K. A., Harris, P., Nahn, S., Rudolph, M., Sung, K., Betchart, B., Demina, R., Gotra, Y., Korjenevski, S., Miner, D., Orbaker, D., Christofek, L., Hooper, R., Landsberg, G., Nguyen, D., Narain, M., Speer, T., Tsang, K. V., Härkönen, J., Karimäki, V., Lampén, T., Lindén, T., Mäenpää, T., University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), and Helsinki Institute of Physics
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Chiller ,Physics - Instrumentation and Detectors ,Physics::Instrumentation and Detectors ,Silicon Detectors ,CMS ,education ,Monte Carlo method ,FOS: Physical sciences ,114 Physical sciences ,01 natural sciences ,Large detector systems for particle and astroparticle physics ARXIV EPRINT ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,Data acquisition ,Particle tracking detectors ,0103 physical sciences ,Electronics ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Detectors and Experimental Techniques ,010306 general physics ,Instrumentation ,Mathematical Physics ,Physics ,Large Hadron Collider ,010308 nuclear & particles physics ,business.industry ,Large detector systems for particle and astroparticle physics ,Emphasis (telecommunications) ,Detector ,Electrical engineering ,Instrumentation and Detectors (physics.ins-det) ,Coolant ,CMS strip tracker ,business ,performance - Abstract
In March 2007 the assembly of the Silicon Strip Tracker was completed at the Tracker Integration Facility at CERN. Nearly 15% of the detector was instrumented using cables, fiber optics, power supplies, and electronics intended for the operation at the LHC. A local chiller was used to circulate the coolant for low temperature operation. In order to understand the efficiency and alignment of the strip tracker modules, a cosmic ray trigger was implemented. From March through July 4.5 million triggers were recorded. This period, referred to as the Sector Test, provided practical experience with the operation of the Tracker, especially safety, data acquisition, power, and cooling systems. This paper describes the performance of the strip system during the Sector Test, which consisted of five distinct periods defined by the coolant temperature. Significant emphasis is placed on comparisons between the data and results from Monte Carlo studies., Comment: 40 pages, 39 figures
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- 2009
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21. Prevalence and prognostic relevance of invasive fungal disease during veno-arterial ECMO: A retrospective single-center study.
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Poth JM, Schmandt M, Schewe JC, Lehmann F, Kreyer S, Kohistani Z, Bakhtiary F, Hischebeth G, Putensen C, Weller J, and Ehrentraut SF
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- Humans, Male, Female, Retrospective Studies, Middle Aged, Prevalence, Prognosis, Adult, Germany epidemiology, Invasive Fungal Infections epidemiology, Invasive Fungal Infections mortality, Length of Stay, Aged, Risk Factors, Invasive Pulmonary Aspergillosis epidemiology, Invasive Pulmonary Aspergillosis mortality, Extracorporeal Membrane Oxygenation, Hospital Mortality
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Purpose: To assess the prevalence and relevance of invasive fungal disease (IFD) during veno-arterial (V-A) extracorporeal membrane oxygenation (ECMO)., Methods: Retrospective analysis from January 2013 to November 2023 of adult V-A ECMO cases at a German University Hospital. Parameters relating to IFD, demographics, length of stay (LoS), days on ECMO and mechanical ventilation, prognostic scores and survival were assessed. Multivariable logistic regression analyses with IFD and death as dependent variables were performed. Outcome was assessed after propensity score matching IFD-patients to non-IFD-controls., Results: 421 patients received V-A ECMO. 392 patients with full electronic datasets were included. The prevalence of IFD, invasive candidiasis and probable invasive pulmonary aspergillosis was 4.6%, 3.8% and 1.0%. Severity of acute disease, pre-existing moderate-to-severe renal disease and continuous kidney replacement therapy were predictive of IFD. In-hospital mortality (94% (17/18) compared to 67% (252/374) in non-IFD patients (p = 0.0156)) was predicted by female sex, SOFA score at admission, SAVE score and IFD (for IFD: OR: 8.31; CI: 1.60-153.18; p: 0.044). There was no difference in outcome after matching IFD-cases to non-IFD-controls., Conclusions: IFD are detected in about one in 20 patients on V-A ECMO, indicating mortality >90%. However, IFD do not contribute to prognosis in this population., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2024
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22. Fit-for-Future: Lessons Learned from the COVID-19 Pandemic in Primary Extracorporeal Membrane Oxygenation (ECMO) Transports of Acute Respiratory Distress Syndrome (ARDS) Patients.
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Muenster S, Schumacher S, Schmandt M, Kreyer S, Poth JM, Putensen C, Schewe JC, and Ehrentraut SF
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(1) Background: The COVID-19 pandemic presented significant challenges in managing acute respiratory distress syndrome (ARDS), with extracorporeal membrane oxygenation (ECMO) being a critical but resource-intensive intervention. (2) Methods: This retrospective study analyzed veno-venous (VV) ECMO therapy in ARDS patients before and during the pandemic at a high-volume ECMO center in Germany. The study used a reduced ECMO team (one medical and one nursing specialist) to optimize patient care with limited resources, aiming to offer insights for future pandemic management. Data from 181 adult patients (age ≥ 18) with severe ARDS were analyzed: 57 pre-pandemic and 124 during the pandemic. (3) Results: Despite increased isolation measures during the pandemic (25% pre-COVID-19 vs. 79% during COVID-19, p < 0.0001), there was no significant change in transportation mode (ground vs. air) or ECMO implantation times at local hospitals. Similarly, time and distance for primary ECMO transport remained unchanged between the two periods. Complication rates related to ECMO circuit placement and prolonged transport were also insignificant across groups. However, ECMO therapy duration (median 12 days pre-COVID-19 vs. 19 days during COVID-19, p < 0.0001) and hospital stays (median 3 days pre-COVID-19 vs. 7 days during COVID-19, p < 0.01) were longer during the pandemic. Mortality rates were also higher during the pandemic (49% pre-COVID-19 vs. 65% during COVID-19, p < 0.05). (4) Conclusions: In conclusion, a reduced ECMO team proved to be an effective resource-saving strategy that maintained high-quality care with low complication rates, despite the additional challenges posed by pandemic-related isolation measures.
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- 2024
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23. Estimation of Cardiac Output Under Veno-Venous Extracorporeal Membrane Oxygenation: Comparing Thermodilution Methods to 3D Echocardiography.
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Linden K, Schmandt M, Muders T, Theuerkauf N, Schewe JC, Herberg U, Putensen C, Ehrentraut SF, and Kreyer S
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Thermodilution methods to determine cardiac output (CO) may be affected by veno-venous extracorporeal membrane oxygenation (ECMO). We compared CO estimations by pulmonary arterial thermodilution using a pulmonary arterial catheter (COPAC), transpulmonary thermodilution (COTPTD), and three-dimensional echocardiography (3DEcho) (CO3DEcho) in 18 patients under veno-venous ECMO. Comparisons between CO3DEcho and COPAC, and COTPTD were performed using correlation statistics and Bland-Altman analysis. Blood flow on ECMO support ranged from 4.3 to 5.8 L/min (median 4.9 L/min). Cardiac output measured with three-dimensional echocardiography was 5.2 L/min (3.8/5.9), COPAC was 7.3 L/min (5.9/7.9), and COTPTD was 7.3 L/min (6/8.2) (median [25%/75% percentile]). Bland-Altman analysis of CO3DEcho and COPAC revealed a mean bias of -2.06 L/min, with limits of agreement from -4.16 to 0.04 L/min. Bland-Altman analysis of CO3DEcho and COTPTD revealed a mean bias of -2.22 L/min, with limits of agreement from -4.18 to -0.25 L/min. We found a negative mean bias and negative limits of agreement between CO3DEcho and COPAC/COTPTD. We concluded an influence on the estimation of CO by thermodilution under ECMO most likely due to loss of indicator resulting in an overestimation of CO. Clinicians should consider this when monitoring thermodilution-based CO under ECMO., Competing Interests: Disclosure: The authors have no conflicts of interest to report., (Copyright © ASAIO 2024.)
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- 2024
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24. Analysis of Patients with Severe ARDS on VV ECMO Treated with Inhaled NO: A Retrospective Observational Study.
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Muenster S, Nadal J, Schewe JC, Ehrentraut H, Kreyer S, Putensen C, and Ehrentraut SF
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(1) Background : This retrospective study focused on severe acute respiratory distress syndrome (ARDS) patients treated with veno-venous (VV) extracorporeal membrane oxygenation (ECMO) and who inhaled nitric oxide (NO) for pulmonary arterial hypertension (PAH) and/or right ventricular failure (RV failure). (2) Methods : Out of 662 ECMO-supported patients, 366 received VV ECMO, including 48 who inhaled NO. We examined the NO's indications, dosing, duration, and the ability to lower PAH. We compared patients with and without inhaled NO in terms of mechanical ventilation duration, ECMO weaning, organ dysfunction, in-hospital mortality, and survival. (3) Results : Patients received 14.5 ± 5.5 ppm NO for 3 days with only one-third experiencing decreased pulmonary arterial pressure. They spent more time on VV ECMO, had a higher ECMO weaning failure frequency, and elevated severity scores (SAPS II and TIPS). A Kaplan-Meier analysis revealed reduced survival in the NO group. Multiple variable logistic regression indicated a twofold increased risk of death for ARDS patients on VV ECMO with NO. We observed no increase in continuous renal replacement therapy. (4) Conclusions : This study suggests that persistent PAH and/or RV failure is associated with poorer outcomes in severe ARDS patients on VV-ECMO, with an inhaled NO responder rate of only 30%, and it does not impact acute kidney failure rates.
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- 2024
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25. COVID-19 Is an Independent Risk Factor for Detrimental Invasive Fungal Disease in Patients on Veno-Venous Extracorporeal Membrane Oxygenation: A Retrospective Study.
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Poth JM, Schewe JC, Lehmann F, Weller J, Schmandt MW, Kreyer S, Muenster S, Putensen C, and Ehrentraut SF
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Invasive fungal disease (IFD) is associated with the mortality of patients on extracorporeal membrane oxygenation (ECMO). Several risk factors for IFD have been identified in patients with or without ECMO. Here, we assessed the relevance of coronavirus disease (COVID-19) for the occurrence of IFD in patients on veno-venous (V-V) ECMO for respiratory failure. In a retrospective analysis of all ECMO cases between January 2013 and December 2022 (2020-2022 for COVID-19 patients), active COVID-19 and the type, timing and duration of IFD were investigated. Demographics, hospital, ICU length of stay (LoS), duration of ECMO, days on invasive mechanical ventilation, prognostic scores (Respiratory ECMO Survival Prediction (RESP) score, Charlson Comorbidity Index (CCI), Therapeutic Intervention Scoring System (TISS)-10, Sequential Organ Failure Assessment (SOFA) score and Simplified Acute Physiology Score (SAPS)-II) and length of survival were assessed. The association of COVID-19 with IFD was investigated using propensity score matching and uni- and multivariable logistic regression analyses. We identified 814 patients supported with ECMO, and 452 patients were included in further analyses. The incidence of IFD was 4.8% and 11.0% in patients without and with COVID-19, respectively. COVID-19 status represented an independent risk factor for IFD (OR 4.30; CI 1.72-10.85; p : 0.002; multivariable regression analysis). In patients with COVID-19, 84.6% of IFD was candidemia and 15.4% represented invasive aspergillosis (IA). All of these patients died. In patients on V-V ECMO, we report that COVID-19 is an independent risk factor for IFD, which is associated with a detrimental prognosis. Further studies are needed to investigate strategies of antifungal therapy or prophylaxis in these patients.
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- 2023
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26. Cardiovascular Magnetic Resonance in Survivors of Critical Illness: Cardiac Abnormalities Are Associated With Acute Kidney Injury.
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Isaak A, Pomareda I, Mesropyan N, Kravchenko D, Endler C, Bischoff L, Pieper CC, Kuetting D, Attenberger U, Zimmer S, Putensen C, Schewe JC, Kreyer S, and Luetkens JA
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- Male, Humans, Adult, Contrast Media, Critical Illness, Gadolinium, Magnetic Resonance Imaging, Cine, Fibrosis, Magnetic Resonance Spectroscopy, Survivors, Cardiomyopathies diagnostic imaging, Cardiomyopathies etiology, Cardiomyopathies pathology, Heart Defects, Congenital, Acute Kidney Injury diagnosis, Acute Kidney Injury etiology
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Background The objective of this study was to investigate cardiac abnormalities in intensive care unit (ICU) survivors of critical illness and to determine whether temporary acute kidney injury (AKI) is associated with more pronounced findings on cardiovascular magnetic resonance. Methods and Results There were 2175 patients treated in the ICU (from 2015 until 2021) due to critical illness who were screened for study eligibility. Post-ICU patients without known cardiac disease were prospectively recruited from March 2021 to May 2022. Participants underwent cardiovascular magnetic resonance including assessment of cardiac function, myocardial edema, late gadolinium enhancement, and mapping including extracellular volume fraction. Student t test, Mann-Whitney U test, and χ
2 tests were used. There were 48 ICU survivors (46±15 years of age, 28 men, 29 with AKI and continuous kidney replacement therapy, and 19 without AKI) and 20 healthy controls who were included. ICU survivors had elevated markers of myocardial fibrosis (T1: 995±31 ms versus 957±21 ms, P <0.001; extracellular volume fraction: 24.9±2.5% versus 22.8±1.2%, P <0.001; late gadolinium enhancement: 1% [0%-3%] versus 0% [0%-0%], P <0.001), more frequent focal late gadolinium enhancement lesions (21% versus 0%, P =0.03), and an impaired left ventricular function (eg, ejection fraction: 57±6% versus 60±5%, P =0.03; systolic longitudinal strain: 20.3±3.7% versus 23.1±3.5%, P =0.004) compared with healthy controls. ICU survivors with AKI had higher myocardial T1 (1002±33 ms versus 983±21 ms; P =0.046) and extracellular volume fraction values (25.6±2.6% versus 23.9±1.9%; P =0.02) compared with participants without AKI. Conclusions ICU survivors of critical illness without previously diagnosed cardiac disease had distinct abnormalities on cardiovascular magnetic resonance including signs of myocardial fibrosis and systolic dysfunction. Findings were more abnormal in participants who experienced AKI with necessity of continuous kidney replacement therapy during their ICU stay. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT05034588.- Published
- 2023
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27. Sensitive and simultaneous quantification of 16 neurotransmitters and metabolites in murine microdialysate by fast liquid chromatography-tandem mass spectrometry.
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Becker S, Schulz A, Kreyer S, Dreßler J, Richter A, and Helmschrodt C
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- Animals, Mice, Chromatography, Liquid, Neurotransmitter Agents, gamma-Aminobutyric Acid, Serotonin, Tandem Mass Spectrometry
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The sensitive and simultaneous measurement of multiple neurotransmitters in microdialysate (MD) of freely moving mice is a prerequisite to study neurochemical imbalances in specific brain regions. The quantitative analysis of 16 neurotransmitters and metabolites, including serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), melatonin (ME), dopamine (DA), levodopa (l-DOPA), 3-methoxytyramine (3-MT), norepinephrine (NE), epinephrine (EP), homovanillinic acid (HVA), acetylcholine (ACh), deoxy carnitine (iso-ACh), choline (Ch), and ɣ-aminobutyric acid (GABA), adenosine (ADE), glutamine (Gln), and glutamic acid (Glu) was achieved within a chromatographic separation time of 6.5 min by the application of a biphenyl column coupled to an API-QTrap 5500 (AB SCIEX) mass spectrometer. Optimized chromatographic separation as well as high sensitivity allow the simultaneous analysis and precise quantification of 16 neurotransmitters and metabolites in artificial cerebrospinal fluid (CSF). Sample preparation procedure consisted of simply adding isotopically labeled internal standard solution to the microdialysis sample. The limits of detection in aCSF ranged from 0.025 pg (Ch) to 9.75 pg (Gln) and 85.5 pg (HVA) on column. Recoveries were between 83 and 111% for neurotransmitter concentrations from 0.6 to 45 ng/ml or 200 ng/ml with a mean intra-day and inter-day coefficient of variation of 7.6% and 11.2%, respectively. Basal extracellular concentrations of the following analytes: 5-HT, 5-HIAA, ME, DA, 3-MT, HVA, ACh, iso-ACh, Ch, GABA, ADE, Gln, and Glu were determined in the striatum of mice with a MD flow rate of 0.5 μl/min. This LC-MS/MS method leads to an accurate quantification of ACh and its isobaric structure iso-ACh, which were detected in the MD samples at ratios of 1:8.6. The main advantage of the high sensitivity is the miniaturization of the MD protocol with short sample collection times and volumes down to 5 μl, which makes this method suitable for pharmacological intervention and optogenetic studies to detect neurochemical changes in vivo., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2023
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28. Monitoring of Cerebral Oxygen Saturation in Interhospital Transport of Patients Receiving Extracorporeal Membrane Oxygenation.
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Schewe JC, Schumacher S, Erdfelder F, Ehrentraut SF, Weißbrich C, Lehmann F, Kögl F, Muders T, Thudium M, Putensen C, and Kreyer S
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- Adult, Humans, Oxygen, Oxygen Saturation, Pulmonary Gas Exchange, Extracorporeal Membrane Oxygenation methods, Respiratory Distress Syndrome therapy
- Abstract
Extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome (ARDS) is used to achieve oxygenation and protect lung ventilation. Near infrared spectroscopy (NIRS) measures cerebral regional tissue oxygenation (rSO 2 ) and may contribute to patient safety during interhospital transport under ECMO support. We evaluated 16 adult ARDS patients undergoing interhospital ECMO transport by measuring cerebral rSO 2 before and after initiation of ECMO support and continuously during transport. To compare peripheral oxygen saturation (SpO 2 ) measurement with rSO 2 , both parameters were analyzed. NIRS monitoring for initiation of ECMO and interhospital transport under ECMO support was feasible, and there was no significant difference in the percentage of achievable valid measurements over time between cerebral rSO 2 (88.4% [95% confidence interval {CI}, 81.3-95.0%]) and standard SpO 2 monitoring 91.7% (95% CI, 86.1-94.2%), p = 0.68. No change in cerebral rSO 2 was observed before 77% (73.5-81%) (median [interquartile range {IQR}]) and after initiation of ECMO support 78% (75-81%), p = 0.2. NIRS for cerebral rSO 2 measurement is feasible during ECMO initiation and interhospital transport. Achievement of valid measurements of cerebral rSO 2 was not superior to SpO 2 . In distinct patients ( e.g. , shock), measurement of cerebral rSO 2 may contribute to improvement of patient safety during interhospital ECMO transport., Competing Interests: Disclosure: J.C.S. and T.M. have received lecture honoraria and travel grants from Maquet Getinge, Germany. S.S. has received travel support from Maquet Getinge, Germany. All other authors declare no conflict of interest., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO.)
- Published
- 2023
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29. Role of acquired von Willebrand syndrome in the development of bleeding complications in patients treated with Impella RP devices.
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Oezkur M, Reda S, Rühl H, Theuerkauf N, Kreyer S, Duerr GD, Charitos E, Silaschi M, Medina M, Zimmer S, Putensen C, and Treede H
- Subjects
- Aged, Blood Coagulation drug effects, Blood Coagulation Tests, Female, Heart Failure etiology, Heart Failure therapy, Humans, Male, Middle Aged, Partial Thromboplastin Time, Treatment Outcome, von Willebrand Diseases etiology, von Willebrand Diseases therapy, Anticoagulants administration & dosage, Heart-Assist Devices, Hemorrhage etiology, Hemorrhage therapy, von Willebrand Diseases complications
- Abstract
Axial flow pumps are standard treatment in cases of cardiogenic shock and high-risk interventions in cardiology and cardiac surgery, although the optimal anticoagulation strategy remains unclear. We evaluated whether laboratory findings could predict bleeding complications and acquired von Willebrand syndrome (avWS) among patients who were treated using axial flow pumps. We retrospectively evaluated 60 consecutive patients who received Impella devices (Impella RP: n = 20, Impella CP/5.0: n = 40; Abiomed Inc., Danvers, USA) between January 2019 and December 2020. Thirty-two patients (53.3%) experienced major or fatal bleeding complications (Bleeding Academic Research Consortium score of > 3) despite intravenous heparin being used to maintain normal activated partial thromboplastin times (40-50 s). Extensive testing was performed for 28 patients with bleeding complications (87.5%). Relative to patients with left ventricular support, patients with right ventricular support were less likely to develop avWS (87.5% vs. 58.8%, p = 0.035). Bleeding was significantly associated with avWS (odds ratio [OR]: 20.8, 95% confidence interval [CI]: 3.3-128.5; p = 0.001) and treatment duration (OR: 1.3, 95% CI 1.09-1.55; p = 0.003). Patients with avWS had longer Impella treatment than patients without avWS (2 days [1-4.7 days] vs. 7.3 days [3.2-13.0 days]). Bleeding complications during Impella support were associated with avWS in our cohort, while aPTT monitoring was not sufficient to prevent bleeding complications. A more targeted anticoagulation monitoring might be needed for patients who receive Impella devices., (© 2021. The Author(s).)
- Published
- 2021
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30. Assessment of spontaneous breathing during pressure controlled ventilation with superimposed spontaneous breathing using respiratory flow signal analysis.
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Kreyer S, Baker WL, Scaravilli V, Linden K, Belenkiy SM, Necsoiu C, Muders T, Putensen C, Chung KK, Cancio LC, and Batchinsky AI
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- Animals, Continuous Positive Airway Pressure, Female, Humans, Lung, Sheep, Tidal Volume, Respiration, Respiration, Artificial
- Abstract
Integrating spontaneous breathing into mechanical ventilation (MV) can speed up liberation from it and reduce its invasiveness. On the other hand, inadequate and asynchronous spontaneous breathing has the potential to aggravate lung injury. During use of airway-pressure-release-ventilation (APRV), the assisted breaths are difficult to measure. We developed an algorithm to differentiate the breaths in a setting of lung injury in spontaneously breathing ewes. We hypothesized that differentiation of breaths into spontaneous, mechanical and assisted is feasible using a specially developed for this purpose algorithm. Ventilation parameters were recorded by software that integrated ventilator output variables. The flow signal, measured by the EVITA® XL (Lübeck, Germany), was measured every 2 ms by a custom Java-based computerized algorithm (Breath-Sep). By integrating the flow signal, tidal volume (V
T ) of each breath was calculated. By using the flow curve the algorithm separated the different breaths and numbered them for each time point. Breaths were separated into mechanical, assisted and spontaneous. Bland Altman analysis was used to compare parameters. Comparing the values calculated by Breath-Sep with the data from the EVITA® using Bland-Altman analyses showed a mean bias of - 2.85% and 95% limits of agreement from - 25.76 to 20.06% for MVtotal . For respiratory rate (RR) RRset a bias of 0.84% with a SD of 1.21% and 95% limits of agreement from - 1.53 to 3.21% were found. In the cluster analysis of the 25th highest breaths of each group RRtotal was higher using the EVITA®. In the mechanical subgroup the values for RRspont and MVspont the EVITA® showed higher values compared to Breath-Sep. We developed a computerized method for respiratory flow-curve based differentiation of breathing cycle components during mechanical ventilation with superimposed spontaneous breathing. Further studies in humans and optimizing of this technique is necessary to allow for real-time use at the bedside., (© 2020. The Author(s).)- Published
- 2021
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31. Measurement of Electrical Impedance Tomography-Based Regional Ventilation Delay for Individualized Titration of End-Expiratory Pressure.
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Muders T, Hentze B, Kreyer S, Wodack KH, Leonhardt S, Hedenstierna G, Wrigge H, and Putensen C
- Abstract
Rationale: Individualized positive end-expiratory pressure (PEEP) titration might be beneficial in preventing tidal recruitment. To detect tidal recruitment by electrical impedance tomography (EIT), the time disparity between the regional ventilation curves (regional ventilation delay inhomogeneity [RVDI]) can be measured during controlled mechanical ventilation when applying a slow inflation of 12 mL/kg of body weight (BW). However, repeated large slow inflations may result in high end-inspiratory pressure (P
EI ), which might limit the clinical applicability of this method. We hypothesized that PEEP levels that minimize tidal recruitment can also be derived from EIT-based RVDI through the use of reduced slow inflation volumes., Methods: Decremental PEEP trials were performed in 15 lung-injured pigs. The PEEP level that minimized tidal recruitment was estimated from EIT-based RVDI measurement during slow inflations of 12, 9, 7.5, or 6 mL/kg BW. We compared RVDI and PEI values resulting from different slow inflation volumes and estimated individualized PEEP levels., Results: RVDI values from slow inflations of 12 and 9 mL/kg BW showed excellent linear correlation ( R2 = 0.87, p < 0.001). Correlations decreased for RVDI values from inflations of 7.5 ( R2 = 0.68, p < 0.001) and 6 ( R2 = 0.42, p < 0.001) mL/kg BW. Individualized PEEP levels estimated from 12 and 9 mL/kg BW were comparable (bias -0.3 cm H2 O ± 1.2 cm H2 O). Bias and scatter increased with further reduction in slow inflation volumes (for 7.5 mL/kg BW, bias 0 ± 3.2 cm H2 O; for 6 mL/kg BW, bias 1.2 ± 4.0 cm H2 O). PEI resulting from 9 mL/kg BW inflations were comparable with PEI during regular tidal volumes., Conclusions: PEEP titration to minimize tidal recruitment can be individualized according to EIT-based measurement of the time disparity of regional ventilation courses during slow inflations with low inflation volumes. This sufficiently decreases PEI and may reduce potential clinical risks.- Published
- 2021
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32. Secondary ARDS Following Acute Pancreatitis: Is Extracorporeal Membrane Oxygenation Feasible or Futile?
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Schmandt M, Glowka TR, Kreyer S, Muders T, Muenster S, Theuerkauf NU, Kalff JC, Putensen C, Schewe JC, and Ehrentraut SF
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Objective: To assess the feasibility of extracorporeal membrane oxygenation (ECMO) or life support (ECLS) as last resort life support therapy in patients with acute pancreatitis and subsequent secondary acute respiratory distress syndrome (ARDS)., Methods: Retrospective analysis from January 2013, to April 2020, of ECMO patients with pancreatitis-induced ARDS at a German University Hospital. Demographics, hospital and ICU length of stay, duration of ECMO therapy, days on mechanical ventilation, fluid balance, need for decompressive laparotomy, amount of blood products, prognostic scores (CCI (Charlson Comorbidity Index), SOFA (Sequential Organ Failure Assessment), RESP(Respiratory ECMO Survival Prediction), SAVE (Survival after Veno-Arterial ECMO)), and the total known length of survival were assessed., Results: A total of n = 495 patients underwent ECMO. Eight patients with acute pancreatitis received ECLS (seven veno-venous, one veno-arterial). Five (71%) required decompressive laparotomy as salvage therapy due to abdominal hypertension. Two patients with acute pancreatitis (25%) survived to hospital discharge. The overall median length of survival was 22 days. Survivors required less fluid in the first 72 h of ECMO support and showed lower values for all prognostic scores., Conclusion: ECLS can be performed as a rescue therapy in patients with pancreatitis and secondary ARDS, but nevertheless mortality remains still high. Thus, this last-resort therapy may be best suited for patients with fewer pre-existing comorbidities and no other organ failure.
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- 2021
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33. CT fatty muscle fraction as a new parameter for muscle quality assessment predicts outcome in venovenous extracorporeal membrane oxygenation.
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Faron A, Kreyer S, Sprinkart AM, Muders T, Ehrentraut SF, Isaak A, Fimmers R, Pieper CC, Kuetting D, Schewe JC, Attenberger U, Putensen C, and Luetkens JA
- Subjects
- Adult, Aged, Disease-Free Survival, Female, Humans, Male, Middle Aged, Retrospective Studies, Survival Rate, Adipose Tissue diagnostic imaging, Extracorporeal Membrane Oxygenation, Models, Biological, Muscle, Skeletal diagnostic imaging, Respiratory Distress Syndrome diagnostic imaging, Respiratory Distress Syndrome mortality, Respiratory Distress Syndrome therapy, Tomography, X-Ray Computed
- Abstract
Impaired skeletal muscle quality is a major risk factor for adverse outcomes in acute respiratory failure. However, conventional methods for skeletal muscle assessment are inapplicable in the critical care setting. This study aimed to determine the prognostic value of computed tomography (CT) fatty muscle fraction (FMF) as a biomarker of muscle quality in patients undergoing extracorporeal membrane oxygenation (ECMO). To calculate FMF, paraspinal skeletal muscle area was obtained from clinical CT and separated into areas of fatty and lean muscle based on densitometric thresholds. The cohort was binarized according to median FMF. Patients with high FMF displayed significantly increased 1-year mortality (72.7% versus 55.8%, P = 0.036) on Kaplan-Meier analysis. A multivariable logistic regression model was built to test the impact of FMF on outcome. FMF was identified as a significant predictor of 1-year mortality (hazard ratio per percent FMF, 1.017 [95% confidence interval, 1.002-1.033]; P = 0.031), independent of anthropometric characteristics, Charlson Comorbidity Index, Simplified Acute Physiology Score, Respiratory Extracorporeal Membrane Oxygenation Survival Prediction Score, and duration of ECMO support. To conclude, FMF predicted 1-year mortality independently of established clinical prognosticators in ECMO patients and may have the potential to become a new muscle quality imaging biomarker, which is available from clinical CT.
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- 2020
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34. Individualized Positive End-expiratory Pressure and Regional Gas Exchange in Porcine Lung Injury.
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Muders T, Luepschen H, Meier T, Reske AW, Zinserling J, Kreyer S, Pikkemaat R, Maripu E, Leonhardt S, Hedenstierna G, Putensen C, and Wrigge H
- Subjects
- Animals, Female, Lung Injury diagnostic imaging, Male, Swine, Tidal Volume physiology, Lung Injury metabolism, Lung Injury therapy, Positive-Pressure Respiration methods, Pulmonary Gas Exchange physiology, Respiratory Mechanics physiology
- Abstract
Background: In acute respiratory failure elevated intraabdominal pressure aggravates lung collapse, tidal recruitment, and ventilation inhomogeneity. Low positive end-expiratory pressure (PEEP) may promote lung collapse and intrapulmonary shunting, whereas high PEEP may increase dead space by inspiratory overdistension. The authors hypothesized that an electrical impedance tomography-guided PEEP approach minimizing tidal recruitment improves regional ventilation and perfusion matching when compared to a table-based low PEEP/no recruitment and an oxygenation-guided high PEEP/full recruitment strategy in a hybrid model of lung injury and elevated intraabdominal pressure., Methods: In 15 pigs with oleic acid-induced lung injury intraabdominal pressure was increased by intraabdominal saline infusion. PEEP was set in randomized order: (1) guided by a PEEP/inspired oxygen fraction table, without recruitment maneuver; (2) minimizing tidal recruitment guided by electrical impedance tomography after a recruitment maneuver; and (3) maximizing oxygenation after a recruitment maneuver. Single photon emission computed tomography was used to analyze regional ventilation, perfusion, and aeration. Primary outcome measures were differences in PEEP levels and regional ventilation/perfusion matching., Results: Resulting PEEP levels were different (mean ± SD) with (1) table PEEP: 11 ± 3 cm H2O; (2) minimal tidal recruitment PEEP: 22 ± 3 cm H2O; and (3) maximal oxygenation PEEP: 25 ± 4 cm H2O; P < 0.001. Table PEEP without recruitment maneuver caused highest lung collapse (28 ± 11% vs. 5 ± 5% vs. 4 ± 4%; P < 0.001), shunt perfusion (3.2 ± 0.8 l/min vs. 1.0 ± 0.8 l/min vs. 0.7 ± 0.6 l/min; P < 0.001) and dead space ventilation (2.9 ± 1.0 l/min vs. 1.5 ± 0.7 l/min vs. 1.7 ± 0.8 l/min; P < 0.001). Although resulting in different PEEP levels, minimal tidal recruitment and maximal oxygenation PEEP, both following a recruitment maneuver, had similar effects on regional ventilation/perfusion matching., Conclusions: When compared to table PEEP without a recruitment maneuver, both minimal tidal recruitment PEEP and maximal oxygenation PEEP following a recruitment maneuver decreased shunting and dead space ventilation, and the effects of minimal tidal recruitment PEEP and maximal oxygenation PEEP were comparable.
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- 2020
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35. Extensive Therapeutic Drug Monitoring of Colistin in Critically Ill Patients Reveals Undetected Risks.
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Ehrentraut SF, Muenster S, Kreyer S, Theuerkauf NU, Bode C, Steinhagen F, Ehrentraut H, Schewe JC, Weber M, Putensen C, and Muders T
- Abstract
(1) Background: With the rise of multi-/pan-drug resistant (MDR/PDR) pathogens, the less utilized antibiotic Colistin has made a comeback. Colistin fell out of favor due to its small therapeutic range and high potential for toxicity. Today, it is used again as a last resort substance in treating MDR/PDR pathogens. Although new guidelines with detailed recommendations for Colistin dosing are available, finding the right dose in critically ill patients with renal failure remains difficult. Here, we evaluate the efficiency of the current guidelines' recommendations by using high resolution therapeutic drug monitoring of Colistin. (2) Methods: We analyzed plasma levels of Colistin and its prodrug colisthimethate sodium (CMS) in 779 samples, drawn from eight PDR-infected ICU patients, using a HPLC-MS/MS approach. The impact of renal function on proper Colistin target levels was assessed. (3) Results: CMS levels did not correlate with Colistin levels. Over-/Underdosing occurred regardless of renal function and mode of renal replacement therapy. Colistin elimination half-time appeared to be longer than previously reported. (4) Conclusion: Following dose recommendations from the most current guidelines does not necessarily lead to adequate Colistin plasma levels. Use of Colistin without therapeutic drug monitoring might be unsafe and guideline adherence does not warrant efficient target levels in critically ill patients.
- Published
- 2020
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36. 1 H-NMR Metabolomics Identifies Significant Changes in Metabolism over Time in a Porcine Model of Severe Burn and Smoke Inhalation.
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Hendrickson C, Linden K, Kreyer S, Beilman G, Scaravilli V, Wendorff D, Necsoiu C, Batchinsky AI, Cancio LC, Chung KK, and Lusczek ER
- Abstract
Burn injury initiates a hypermetabolic response leading to muscle catabolism and organ dysfunction but has not been well-characterized by high-throughput metabolomics. We examined changes in metabolism over the first 72 h post-burn using proton nuclear magnetic resonance (
1 H-NMR) spectroscopy and serum from a porcine model of severe burn injury. We sought to quantify the changes in metabolism that occur over time in response to severe burn and smoke inhalation in this preliminary study. Fifteen pigs received 40% total body surface area (TBSA) burns with additional pine bark smoke inhalation. Arterial blood was drawn at baseline (pre-burn) and every 24 h until 72 h post-injury or death. The aqueous portion of each serum sample was analyzed using1 H-NMR spectroscopy and metabolite concentrations were used for principal component analysis (PCA). Thirty-eight metabolites were quantified in 39 samples. Of these, 31 showed significant concentration changes over time ( p < 0.05). PCA revealed clustering of samples by time point on a 2D scores plot. The first 48 h post-burn were characterized by high concentrations of histamine, alanine, phenylalanine, and tyrosine. Later timepoints were characterized by rising concentrations of 2-hydroxybutyrate, 3-hydroxybutyrate, acetoacetate, and isovalerate. No significant differences in metabolism related to mortality were observed. Our work highlights the accumulation of organic acids resulting from fatty acid catabolism and oxidative stress. Further studies will be required to relate accumulation of the four organic carboxylates identified in this analysis to outcomes from burn injury.- Published
- 2019
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37. Interprofessional two-man team approach for interhospital transport of ARDS-patients under extracorporeal membrane oxygenation: a 10 years retrospective observational cohort study.
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Ehrentraut SF, Schroll B, Lenkeit S, Ehrentraut H, Bode C, Kreyer S, Kögl F, Lehmann F, Muders T, Scholz M, Strater C, Steinhagen F, Theuerkauf NU, Weißbrich C, Putensen C, and Schewe JC
- Subjects
- Adolescent, Adult, Aged, Anesthesiologists organization & administration, Cohort Studies, Female, Germany, Hospitals, University, Humans, Male, Middle Aged, Nursing Staff, Hospital organization & administration, Retrospective Studies, Young Adult, Extracorporeal Membrane Oxygenation methods, Patient Care Team organization & administration, Patient Transfer organization & administration, Respiratory Distress Syndrome therapy
- Abstract
Background: Extra Corporeal Membrane Oxygenation (ECMO) has become an accepted treatment option for severely ill patients. Due to a limited availability of ECMO support therapy, patients must often be transported to a specialised centre before or after cannulation. According to the ELSO guidelines, an ECMO specialist should be present for such interventions. Here we describe the safety and efficacy of a reduced team approach involving one anaesthesiologist, experienced in specialised intensive care medicine, and a specialised critical care nurse., Methods: This study is a 10 years retrospective, single institution analysis of all data collected between January 2007 and December 2016 from the medical records at the University Hospital Bonn, Germany., Results: The Bonner mobile ECMO team was deployed in 170 cases for on-site evaluation for ECMO support therapy. 4 (2.4%) patients died prior to arrival or during the implementation of ECMO support. Of the remaining 166 patients, 126 were cannulated at the referring site, 40 were transported without ECMO. Of those, 21 were subsequently cannulated out our centre. 19 patients never received ECMO treatment. The primary indication for ECMO treatment was ARDS (159/166 patients). Veno-venous ECMO was initiated in 137, whilst 10 patients received veno-arterial ECMO treatment. Mean transportation time was 75 ± 36 min, and mean transport distance was 56 ± 57 km. In total, 26 complications were observed, three being directly transport-related. The overall survival was 55%., Conclusions: Initiation of extracorporeal membrane oxygenation and subsequent transport can be safely and efficiently performed by a two-man team with good outcome.
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- 2019
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38. Hemorrhage under veno-venous extracorporeal membrane oxygenation in acute respiratory distress syndrome patients: a retrospective data analysis.
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Kreyer S, Muders T, Theuerkauf N, Spitzhüttl J, Schellhaas T, Schewe JC, Guenther U, Wrigge H, and Putensen C
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Background: Despite being still invasive and challenging, technical improvement has resulted in broader and more frequent application of extracorporeal membrane oxygenation (ECMO), to prevent hypoxemia and to reduce invasiveness of mechanical ventilation (MV). Heparin-coated ECMO-circuits are currently standard of care, in addition to heparin based anticoagulation (AC) regimen guided by activated clotting time (ACT) or activated partial thromboplastin time (aPTT). Despite these advances, a reliable prediction of hemorrhage is difficult and the risk of hemorrhagic complication remains unfortunately high. We hypothesized, that there are coagulation parameters that are indices for a higher risk of hemorrhage under veno-venous (VV)-ECMO therapy., Methods: Data from 36 patients with severe respiratory failure treated with VV-ECMO at a University Hospital intensive care unit (ICU) were analyzed retrospectively. Patients were separated into two groups based on severity of hemorrhagic complications and transfusion requirements. The following data were collected: demographics, hemodynamic data, coagulation samples, transfusion requirements, change of ECMO-circuit during treatment and adverse effects, including hemorrhage and thrombosis., Results: In this study 74 hemorrhagic events were observed, one third of which were severe. Patients suffering from severe hemorrhage had a lower survival rate on VV-ECMO (43% vs . 91%; P=0.002) and in ICU (36% vs . 86%; P=0.002). SAPS II, factor VII and X were different between mild and severe hemorrhage group., Conclusions: Severe hemorrhage under VV-ECMO is associated with higher mortality. Only factor VII and X differed between groups. Further clinical studies are required to determine the timing of initiation and targets for AC therapies during VV-ECMO., Competing Interests: Conflicts of Interest: Part of these data has been presented in form of abstracts at the American Thoracic Society international conference 2010 (New Orleans) and at the European Society of Intensive Care Medicine annual congress 2010 (Barcelona).
- Published
- 2017
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39. Effects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS.
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Hering R, Kreyer S, and Putensen C
- Subjects
- Acidosis, Respiratory physiopathology, Animals, Cardiac Output physiology, Hemodynamics physiology, Respiratory Distress Syndrome physiopathology, Respiratory Mechanics physiology, Swine, Treatment Outcome, Acidosis, Respiratory therapy, Disease Models, Animal, Regional Blood Flow physiology, Respiration, Artificial methods, Respiratory Distress Syndrome therapy
- Abstract
Background: Lung protective mechanical ventilation with limited peak inspiratory pressure has been shown to affect cardiac output in patients with ARDS. However, little is known about the impact of lung protective mechanical ventilation on regional perfusion, especially when associated with moderate permissive respiratory acidosis. We hypothesized that lung protective mechanical ventilation with limited peak inspiratory pressure and moderate respiratory acidosis results in an increased cardiac output but unequal distribution of blood flow to the different organs of pigs with oleic-acid induced ARDS., Methods: Twelve pigs were enrolled, 3 died during instrumentation and induction of lung injury. Thus, 9 animals received pressure controlled mechanical ventilation with a PEEP of 5 cmH
2 O and limited peak inspiratory pressure (17 ± 4 cmH2 O) versus increased peak inspiratory pressure (23 ± 6 cmH2 O) in a crossover-randomized design and were analyzed. The sequence of limited versus increased peak inspiratory pressure was randomized using sealed envelopes. Systemic and regional hemodynamics were determined by double indicator dilution technique and colored microspheres, respectively. The paired student t-test and the Wilcoxon test were used to compare normally and not normally distributed data, respectively., Results: Mechanical ventilation with limited inspiratory pressure resulted in moderate hypercapnia and respiratory acidosis (PaCO2 71 ± 12 vs. 46 ± 9 mmHg, and pH 7.27 ± 0.05 vs. 7.38 ± 0.04, p < 0.001, respectively), increased cardiac output (140 ± 32 vs. 110 ± 22 ml/min/kg, p<0.05) and regional blood flow in the myocardium, brain and spinal cord, adrenal and thyroid glands, the mucosal layers of the esophagus and jejunum, the muscularis layers of the esophagus and duodenum, and the gall and urinary bladders. Perfusion of kidneys, pancreas, spleen, hepatic arterial bed, and the mucosal and muscularis blood flow to the other evaluated intestinal regions remained unchanged., Conclusions: In this porcine model of ARDS mechanical ventilation with limited peak inspiratory pressure resulting in moderate respiratory acidosis was associated with an increase in cardiac output. However, the better systemic blood flow was not uniformly directed to the different organs. This observation may be of clinical interest in patients, e.g. with cardiac, renal and cerebral pathologies.- Published
- 2017
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40. Platelet and coagulation function before and after burn and smoke inhalation injury in sheep.
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Prat NJ, Herzig MC, Kreyer S, Montgomery RK, Parida BK, Linden K, Scaravilli V, Belenkiy SM, Cancio LC, Batchinsky AI, and Cap AP
- Subjects
- Animals, Burns therapy, Decision Support Techniques, Disease Models, Animal, Female, Flow Cytometry, Hemostasis, Platelet Aggregation, Platelet Count, Resuscitation methods, Sheep, Smoke Inhalation Injury therapy, Thrombelastography, Blood Coagulation Tests, Blood Platelets physiology, Burns blood, Smoke Inhalation Injury blood
- Abstract
Background: Smoke inhalation and burn injury remain a major source of morbidity and mortality. There is known dysregulation of hemostasis in burn patients, but either hypercoagulation or hypocoagulation states are reported. Sheep are an established animal model for studying burn pathology and provide robust data on hemostatic function at baseline and after injury., Methods: After an IACUC-approved protocol, 15 sheep were anesthetized and subjected to a 40% full thickness burn with smoke inhalation. Blood was sampled at baseline, 1 day postinjury (early effects) and days 2, 3, and 4 (late effects) after injury. Assays at each timepoint assessed: hemostatic function by thromboelastography (TEG), platelet counts and function by flow cytometry and aggregometry, coagulation protein levels, and free hemoglobin. Data were analyzed by the Wilcoxon paired test (nonparametric) with significance set at less than 0.05., Results: By 24 hours postinjury, platelet counts had dropped, whereas the percent activated platelets increased. Absolute platelet functional response to the agonist adenosine diphosphate (ADP) decreased, whereas response to collagen showed no significant difference. On a per platelet basis, ADP response was unchanged, whereas the collagen response was elevated. Prothrombin time and activated partial thromboplastin time were prolonged. TEG parameters decreased significantly from baseline. Fibrinogen and factor V were trending up; coagulation proteins ATIII, factors IX and X were decreased.Late effects were followed in six animals. At day 4, platelet counts remained depressed compared with baseline with a nadir at day 2; responses to agonist on a per platelet basis remained the same for ADP and stayed elevated for collagen. Platelets continued to have elevated activation levels. Fibrinogen and factor V remained significantly elevated, whereas TEG parameters and prothrombin time, factors IX and X returned to near baseline levels., Conclusion: Coagulation parameters and hemostasis are dysregulated in sheep after smoke inhalation and burn. By 24 hours, sheep were hypocoagulable and subsequently became hypercoagulable by day 4. These results suggest a three-stage coagulopathy in burn injuries with a known early consumptive hypercoagulable state which is followed by a relatively hypocoagulable state with increased bleeding risk and then a return to a relatively unknown hypercoagulability with increased susceptibility to thrombotic disorders.
- Published
- 2017
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41. Extracorporeal Carbon Dioxide Removal Enhanced by Lactic Acid Infusion in Spontaneously Breathing Conscious Sheep.
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Scaravilli V, Kreyer S, Belenkiy S, Linden K, Zanella A, Li Y, Dubick MA, Cancio LC, Pesenti A, and Batchinsky AI
- Subjects
- Animals, Consciousness physiology, Infusions, Intravenous, Respiratory Mechanics physiology, Sheep, Carbon Dioxide blood, Consciousness drug effects, Extracorporeal Circulation methods, Lactic Acid administration & dosage, Lactic Acid blood, Respiratory Mechanics drug effects
- Abstract
Background: The authors studied the effects on membrane lung carbon dioxide extraction (VCO2ML), spontaneous ventilation, and energy expenditure (EE) of an innovative extracorporeal carbon dioxide removal (ECCO2R) technique enhanced by acidification (acid load carbon dioxide removal [ALCO2R]) via lactic acid., Methods: Six spontaneously breathing healthy ewes were connected to an extracorporeal circuit with blood flow 250 ml/min and gas flow 10 l/min. Sheep underwent two randomly ordered experimental sequences, each consisting of two 12-h alternating phases of ALCO2R and ECCO2R. During ALCO2R, lactic acid (1.5 mEq/min) was infused before the membrane lung. Caloric intake was not controlled, and animals were freely fed. VCO2ML, natural lung carbon dioxide extraction, total carbon dioxide production, and minute ventilation were recorded. Oxygen consumption and EE were calculated., Results: ALCO2R enhanced VCO2ML by 48% relative to ECCO2R (55.3 ± 3.1 vs. 37.2 ± 3.2 ml/min; P less than 0.001). During ALCO2R, minute ventilation and natural lung carbon dioxide extraction were not affected (7.88 ± 2.00 vs. 7.51 ± 1.89 l/min, P = 0.146; 167.9 ± 41.6 vs. 159.6 ± 51.8 ml/min, P = 0.063), whereas total carbon dioxide production, oxygen consumption, and EE rose by 12% each (223.53 ± 42.68 vs. 196.64 ± 50.92 ml/min, 215.3 ± 96.9 vs. 189.1 ± 89.0 ml/min, 67.5 ± 24.0 vs. 60.3 ± 20.1 kcal/h; P less than 0.001)., Conclusions: ALCO2R was effective in enhancing VCO2ML. However, lactic acid caused a rise in EE that made ALCO2R no different from standard ECCO2R with respect to ventilation. The authors suggest coupling lactic acid-enhanced ALCO2R with active measures to control metabolism.
- Published
- 2016
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42. Early Utilization of Extracorporeal CO2 Removal for Treatment of Acute Respiratory Distress Syndrome Due to Smoke Inhalation and Burns in Sheep.
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Kreyer S, Scaravilli V, Linden K, Belenkiy SM, Necsoiu C, Li Y, Putensen C, Chung KK, Batchinsky AI, and Cancio LC
- Subjects
- Animals, Female, Hemodynamics, Oxygen blood, Partial Pressure, Respiration, Artificial methods, Respiratory Distress Syndrome blood, Respiratory Distress Syndrome etiology, Secondary Prevention methods, Severity of Illness Index, Sheep, Domestic, Burns complications, Carbon Dioxide blood, Extracorporeal Circulation methods, Respiratory Distress Syndrome therapy, Smoke Inhalation Injury complications
- Abstract
Introduction: In thermally injured patients, inhalation injury is often associated with acute respiratory distress syndrome (ARDS), and is an independent predictor of increased morbidity and mortality. Extracorporeal CO2 removal (ECCO2R) therapy offers new possibilities in protective mechanical ventilation in ARDS patients. We performed an early application of ECCO2R in mild-to-moderate ARDS in sheep ventilated in BiPAP mode. Our aim was to investigate its effect on severity of the lung injury., Material and Methods: Non-pregnant farm-bred ewes (n = 15) were anesthetized and injured by a combination of wood-bark smoke inhalation and a 40% total body surface area full-thickness burn, and were observed for 72 h or death. The animals were randomized to a Hemolung group (n = 7) or a Control group (n = 8) at time of ARDS onset. ECCO2R was performed in the Hemolung group after onset of ARDS.Histopathology, CT scans, systemic and pulmonary variables, and CO2 removal were examined., Results: Early application of ECCO2R therapy with Hemolung in spontaneously breathing sheep decreased PaCO2 significantly, while the device removed about 70 mL of CO2 per minute. This did not result in lower minute ventilation in the Hemolung group. Lungpathology and CT scans did not show a difference between groups., Conclusion: In an ovine model of ARDS due to smoke inhalation and burn injury, early institution of ECCO2R in spontaneously breathing animals was effective in removing CO2 and in reducing PaCO2. However, it had no effect on reducing the severity of lung injury or mortality. Further studies are necessary to detail the interaction between extracorporeal CO2 removal and pulmonary physiology.
- Published
- 2016
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43. Enhanced Extracorporeal CO2 Removal by Regional Blood Acidification: Effect of Infusion of Three Metabolizable Acids.
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Scaravilli V, Kreyer S, Linden K, Belenkiy S, Pesenti A, Zanella A, Cancio LC, and Batchinsky AI
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- Acetic Acid metabolism, Acetic Acid pharmacology, Acidosis, Respiratory drug therapy, Acidosis, Respiratory surgery, Animals, Blood Gas Analysis, Calcium metabolism, Carbon Dioxide metabolism, Citric Acid metabolism, Citric Acid pharmacology, Female, Hemodynamics, Lactic Acid metabolism, Lactic Acid pharmacology, Sheep, Acidosis, Respiratory blood, Calcium blood, Carbon Dioxide blood, Carboxylic Acids pharmacology, Extracorporeal Circulation methods, Respiration, Artificial methods
- Abstract
Acidification of blood entering a membrane lung (ML) with lactic acid enhances CO2 removal (VCO2ML). We compared the effects of infusion of acetic, citric, and lactic acids on VCO2ML. Three sheep were connected to a custom-made circuit, consisting of a Hemolung device (Alung Technologies, Pittsburgh, PA), a hemofilter (NxStage, NxStage Medical, Lawrence, MA), and a peristaltic pump recirculating ultrafiltrate before the ML. Blood flow was set at 250 ml/min, gas flow (GF) at 10 L/min, and recirculating ultrafiltrate flow at 100 ml/min. Acetic (4.4 M), citric (0.4 M), or lactic (4.4 M) acids were infused in the ultrafiltrate at 1.5 mEq/min, for 2 hours each, in randomized fashion. VCO2ML was measured by the Hemolung built-in capnometer. Circuit and arterial blood gas samples were collected at baseline and during acid infusion. Hemodynamics and ventilation were monitored. Acetic, citric, or lactic acids similarly enhanced VCO2ML (+35%), from 37.4 ± 3.6 to 50.6 ± 7.4, 49.8 ± 5.6, and 52.0 ± 8.2 ml/min, respectively. Acids similarly decreased pH, increased pCO2, and reduced HCO3 of the post-acid extracorporeal blood sample. No significant effects on arterial gas values, ventilation, or hemodynamics were observed. In conclusion, it is possible to increase VCO2ML by more than one-third using any one of the three metabolizable acids.
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- 2015
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44. Modular extracorporeal life support: effects of ultrafiltrate recirculation on the performance of an extracorporeal carbon dioxide removal device.
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Scaravilli V, Kreyer S, Linden K, Belenkiy S, Jordan B, Pesenti A, Zanella A, Chung K, Cannon J, Cancio LC, and Batchinsky AI
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- Animals, Blood Gas Analysis, Equipment Design, Female, Fluid Therapy methods, Heart Rate, Hemodynamics, Hemofiltration instrumentation, Respiration, Artificial instrumentation, Respiratory Insufficiency therapy, Sheep, Time Factors, Carbon Dioxide chemistry, Extracorporeal Circulation methods, Extracorporeal Membrane Oxygenation methods
- Abstract
The combination of extracorporeal carbon dioxide removal (ECCO2R) and hemofiltration is a possible therapeutic strategy for patients needing both lung and renal support. We tested the effects of the recirculation of ultrafiltrate on membrane lung (ML) CO2 removal (VCO2ML). Three conscious, spontaneously breathing sheep were connected to a commercially produced ECCO2R device (Hemolung; Alung Technologies, Pittsburgh, PA) with a blood flow of 250 ml/min and a gas flow of 10 L/min. A hemofilter (NxStage, NxStage Medical, Lawrence, MA) was interposed in series after the ML. Ultrafiltrate flow was generated and recirculated before the ML. We tested four ultrafiltrate flows (0, 50, 100, and 150 ml/min) for 25 min each, eight times per animal, resulting in 24 randomized test repetitions. We recorded VCO2ML, hemodynamics and ventilatory variables, and natural lung CO2 transfer (VCO2NL) and collected arterial and circuitry blood samples. VCO2ML was unchanged by application of ultrafiltrate recirculation (40.5 ± 4.0, 39.7 ± 4.2, 39.8 ± 4.2, and 39.2 ± 4.1 ml/min, respectively, at ultrafiltrate flow of 0, 50, 100, and 150 ml/min). Minute ventilation, respiratory rate, VCO2NL, and arterial blood analyses were not affected by ultrafiltrate recirculation. In the tested configuration, ultrafiltrate recirculation did not affect VCO2ML. This modular technology may provide a suitable platform for coupling CO2 removal with various forms of blood purification.
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- 2014
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45. The effect of pumpless extracorporeal CO2 removal on regional perfusion of the brain in experimental acute lung injury.
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Kreyer S, Muders T, Luepschen H, Kricklies C, Linden K, Soehle M, Zinserling J, Putensen C, and Wrigge H
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- Acidosis physiopathology, Acute Lung Injury chemically induced, Animals, Blood Gas Analysis, Cardiac Output physiology, Hemodynamics physiology, Hydrochloric Acid, Hydrogen-Ion Concentration, Hypercapnia etiology, Microspheres, Respiratory Mechanics physiology, Swine, Acute Lung Injury physiopathology, Carbon Dioxide analysis, Cerebrovascular Circulation physiology, Extracorporeal Membrane Oxygenation adverse effects, Hypercapnia physiopathology
- Abstract
Background: Lung-protective mechanical ventilation with low tidal volumes (V(T)) is often associated with hypercapnia (HC), which may be unacceptable in patients with brain injury. CO2 removal using a percutaneous extracorporeal lung assist (pECLA) enables normocapnia despite low V(T), but its effects on regional cerebral blood flow (rCBF) remain ambiguous. We hypothesized that reversal of HC by pECLA impairs rCBF in a porcine lung injury model., Methods: Lung injury was induced in 9 anesthetized pigs by hydrochloric acid aspiration. rCBF and systemic hemodynamics were measured by colored microsphere technique and transpulmonary-thermodilution during a randomized sequence of 4 experimental situations: pECLA shunt-on (1) with HC and (2) without HC, pECLA shunt-off (3) with HC and (4) without HC., Results: HC increased rCBF (P<0.05). CO2 removal with pECLA resulting in normocapnia, decreased rCBF to levels comparable to those without pECLA and normocapnia. HC resulted in increased cardiac output (+25.5%). Cardiac output was highest during HC with pECLA shunt (+44.9%). During pECLA with CO2 removal, cardiac output (+38.1%) decreased compared with pECLA without CO2 removal, but stayed higher than during normocapnia/no pECLA shunt (P<0.05)., Conclusions: In this animal model, mechanical ventilation with low V(T) was associated with HC and increased rCBF. CO2 removal by pECLA restored normocapnia, reduced rCBF to levels of normocapnia, but required a higher systemic blood flow for the perfusion of the pECLA device. If these results could be transferred to patients, extracorporeal CO2 removal might be an option for treatment of combined lung and brain injury in condition of a sufficient cardiac flow reserve.
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- 2013
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46. [Alveolar ventilation and recruitment under lung protective ventilation].
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Putensen C, Muders T, Kreyer S, and Wrigge H
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- Blood Pressure, Continuous Positive Airway Pressure, Humans, Intermittent Positive-Pressure Ventilation, Lung Injury physiopathology, Monitoring, Physiologic, Positive-Pressure Respiration adverse effects, Positive-Pressure Respiration methods, Respiration, Artificial adverse effects, Respiratory Distress Syndrome physiopathology, Tomography, X-Ray Computed, Lung Injury prevention & control, Respiration, Artificial methods, Respiratory Distress Syndrome therapy
- Abstract
Goal of mechanical ventilation is to improve gas exchange and reduce work of breathing without contributing to further lung injury. Besides providing adequate EELV and thereby arterial oxygenation PEEP in addition to a reduction in tidal volume is required to prevent cyclic alveolar collapse and tidal recruitment and hence protective mechanical ventilation. Currently, there is no consensus if and if yes at which price alveolar recruitment with high airway pressures should be intended ("open up the lung"), or if it is more important to reduce the mechanical stress and strain to the lungs as much as possible ("keep the lung closed"). Potential of alveolar recruitment differs from patient to patient but also between lung regions. Potential for recruitment depends probably more on regional lung mechanics - especially on lung elastance - than on the underlying disease. Based on available data neither high PEEP nor other methods used for alveolar recruitment could demonstrate a survival benefit in patients with ARDS. These results may support an individualized titration of PEEP or other manoeuvres used for recruitment taking into consideration the regional effects. Bedside imaging techniques allowing titration of PEEP or other manoeuvres to prevent end-expiratory alveolar collapse (tidal recruitment) and inspiratory overinflation may be a promising development.
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- 2008
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47. [Lung protective ventilation - protective effect of adequate supported spontaneous breathing].
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Putensen C, Muders T, Kreyer S, and Wrigge H
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- Germany, Humans, Practice Guidelines as Topic, Practice Patterns, Physicians', Respiration, Artificial adverse effects, Respiration, Artificial methods, Respiratory Distress Syndrome etiology, Respiratory Distress Syndrome prevention & control
- Abstract
Based on available data, it can be suggested that spontaneous breathing during ventilator support has not to be suppressed even in patients with severe pulmonary dysfunction if no contraindications are present. Experimental data do not support the contention that spontaneous breathing aggravates ventilator-induced lung injury. During spontaneous breathing increase in PTP is maximal in the depended lung areas in adjunct to the diaphragm and causes recruitment of initially atelectatic lung areas thereby avoiding cyclic alveolar collapse and reopening. This should result in a lung protective effect of adequate supported spontaneous breathing. Clinical data supported this belief demonstrating improvement in pulmonary gas exchange, systemic blood flow, and oxygen supply to the tissue and a decrease in days on ventilator support and duration of stay in the intensive care unit.
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- 2008
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48. Spontaneous breathing during airway pressure release ventilation in experimental lung injury: effects on hepatic blood flow.
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Hering R, Bolten JC, Kreyer S, Berg A, Wrigge H, Zinserling J, and Putensen C
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- Animals, Cardiac Output physiology, Cross-Over Studies, Liver Circulation physiology, Oleic Acid, Oxygen blood, Respiration, Respiratory Distress Syndrome chemically induced, Respiratory Distress Syndrome physiopathology, Swine, Continuous Positive Airway Pressure, Liver blood supply, Respiratory Distress Syndrome therapy
- Abstract
Objective: Positive pressure ventilation can affect systemic haemodynamics and regional blood flow distribution with negative effects on hepatic blood flow. We hypothesized that spontaneous breathing (SB) with airway pressure release ventilation (APRV) provides better systemic and hepatic blood flow than APRV without SB., Design: Animal study with a randomized cross-over design., Setting: Animal laboratory of Bonn University Hospital., Subjects: Twelve pigs with oleic-acid-induced lung injury., Interventions: APRV with or without SB in random order. Without SB, either the upper airway pressure limit or the ventilator rate was increased to maintain constant pH and PaCO2., Measurements and Results: Systemic haemodynamics were determined by double-indicator dilution, organ blood flow by coloured microspheres. Systemic blood flow was best during APRV with SB. During APRV with SB blood flow (ml g(-1) min(-1)) was 0.91+/-0.26 (hepatic arterial), 0.29+/-0.05 (stomach), 0.64+/-0.08 (duodenum), 0.62+/-0.10 (jejunum), 0.53+/-0.07 (ileum), 0.53+/-0.07 (colon), 0.46+/-0.09 (pancreas) and 3.59+/-0.55 (spleen). During APRV without SB applying high P(aw) it decreased to 0.13+/-0.01 (stomach), 0.37+/-0.03 (duodenum), 0.29+/-0.03 (jejunum), 0.31+/-0.05 (ileum), 0.32+/-0.03 (colon) and 0.23+/-0.04 (pancreas) p<0.01, respectively. During APRV without SB applying same Paw limits it decreased to 0.18+/-0.03 (stomach, p<0.01), 0.47+/-0.06 (duodenum, p<0.05), 0.38+/-0.05 (jejunum, p<0.01), 0.36+/-0.03 (ileum, p<0.05), 0.39+/-0.05 (colon, p<0.05), and 0.27+/-0.04 (pancreas, p<0.01). Arterial liver blood flow did not change significantly when SB was abolished (0.55+/-0.11 and 0.63+/-0.11, respectively)., Conclusions: Maintaining SB during APRV was associated with better systemic and pre-portal organ blood flow. Improvement in hepatic arterial blood flow was not significant.
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- 2008
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49. Effects of spontaneous breathing during airway pressure release ventilation on respiratory work and muscle blood flow in experimental lung injury.
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Hering R, Zinserling J, Wrigge H, Varelmann D, Berg A, Kreyer S, and Putensen C
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- Animals, Blood Pressure, Catheterization, Central Venous, Disease Models, Animal, Electrocardiography, Esophagus physiopathology, Hemodynamics, Pressure, Swine, Wounds and Injuries physiopathology, Exhalation physiology, Inhalation physiology, Lung Injury, Respiratory Muscles physiopathology
- Abstract
Study Objectives: To evaluate the effects of spontaneous breathing at ambient airway pressure (Paw) and during airway pressure release ventilation (APRV) on respiratory work and respiratory muscle blood flow (RMBF) in experimental lung injury., Design: Prospective experimental study., Setting: Research laboratory of a university hospital., Subjects: Twelve hemodynamically stable, analgosedated, and tracheotomized domestic pigs., Measurements: Respiratory work was estimated by the inspiratory pressure time product (PTPinsp) of esophageal pressure, and RMBF was measured with colored microspheres. Lung injury was induced with IV boli of oleic acid. The first set of measurements was performed before induction of lung injury while pigs were breathing spontaneously at ambient Paw, the second after induction of lung injury while breathing spontaneously at ambient Paw, and the third with lung injury and spontaneous breathing with APRV., Results: After induction of lung injury PTPinsp increased from 138 +/- 14 to 214 +/- 32 cm H2O s/min when pigs breathed spontaneously at ambient Paw (p < 0.05) and returned to 128 +/- 27 cm H2O s/min during APRV. While systemic hemodynamics and blood flow to the psoatic and intercostal muscles did not change, diaphragmatic blood flow increased from 0.34 +/- 0.05 before to 0.54 +/- 0.08 mL/g/min after induction of lung injury and spontaneous breathing at ambient Paw (p < 0.05) and returned to 0.32 +/- 0.05 mL/g/min during APRV (p < 0.05 vs spontaneous breathing at ambient Paw [lung injury])., Conclusion: Respiratory work and RMBF are increased in acute lung injury when subjects breathe spontaneously at ambient Paw. Supporting spontaneous breathing with APRV decreases respiratory work and RMBF to physiologic values.
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- 2005
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50. Effects of spontaneous breathing during airway pressure release ventilation on intestinal blood flow in experimental lung injury.
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Hering R, Viehöfer A, Zinserling J, Wrigge H, Kreyer S, Berg A, Minor T, and Putensen C
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- Animals, Blood Gas Analysis, Carbon Dioxide blood, Heart Rate physiology, Pulmonary Gas Exchange physiology, Regional Blood Flow physiology, Swine, Tidal Volume physiology, Intestines blood supply, Lung Injury, Respiration, Artificial, Respiratory Mechanics physiology
- Abstract
Background: In critical illness, the gut is susceptible to hypoperfusion and hypoxia. Positive-pressure ventilation can affect systemic hemodynamics and regional blood flow distribution, with potentially deleterious effects on the intestinal circulation. The authors hypothesized that spontaneous breathing (SB) with airway pressure release ventilation (APRV) provides better systemic and intestinal blood flow than APRV without SB., Methods: Twelve pigs with oleic acid-induced lung injury received APRV with and without SB. When SB was abolished, either the tidal volume or the ventilator rate was increased to maintain pH and arterial carbon dioxide tension constant as compared to APRV with SB. Systemic hemodynamics were determined by double indicator dilution. Blood flow to the intestinal mucosa-submucosa and muscularis-serosa was measured using colored microspheres., Results: Systemic blood flow increased during APRV with SB. During APRV with SB, mucosal-submucosal blood flow (ml. g-1. min-1) was 0.39 +/- 0.21 in the stomach, 0.76 +/- 0.35 in the duodenum, 0.71 +/- 0.35 in the jejunum, 0.71 +/- 0.59 in the ileum, and 0.63 +/- 0.21 in the colon. During APRV without SB and high tidal volumes, it decreased to 0.19 +/- 0.03 in the stomach, 0.42 +/- 0.21 in the duodenum, 0.37 +/- 0.10 in the jejunum, 0.3 +/- 0.14 in the ileum, and 0.41 +/- 0.14 in the colon (P < 0.001, respectively). During APRV without SB and low tidal volumes, the respective mucosal-submucosal blood flows decreased to 0.24 +/- 0.10 (P < 0.01), 0.54 +/- 0.21 (P < 0.05), 0.48 +/- 0.17 (P < 0.01), 0.43 +/- 0.21 (P < 0.01), and 0.50 +/- 0.17 (P < 0.001) as compared to APRV with SB. Muscularis-serosal perfusion decreased during full ventilatory support with high tidal volumes in comparison with APRV with SB., Conclusion: Maintaining SB during APRV was associated with better systemic and intestinal blood flows. Improvements were more pronounced in the mucosal-submucosal layer.
- Published
- 2003
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