1. Radon and lung cancer in the pooled uranium miners analysis (PUMA): highly exposed early miners and all miners.
- Author
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Kelly-Reif, Kaitlin, Bertke, Stephen, Rage, Estelle, Demers, Paul, Fenske, Nora, Deffner, Veronika, Kreuzer, Michaela, Samet, Jonathan, Schubauer-Berigan, Mary, Tomasek, Ladislav, Wiggins, Charles, Laurier, Dominique, Zablotska, Lydia, and Richardson, David
- Subjects
Cancer ,Miners ,Radiation ,Radon ,Humans ,Male ,Middle Aged ,Radon ,Uranium ,Cohort Studies ,Occupational Exposure ,Neoplasms ,Radiation-Induced ,Apoptosis Regulatory Proteins ,Lung Neoplasms ,Occupational Diseases - Abstract
OBJECTIVES: Radon is a ubiquitous occupational and environmental lung carcinogen. We aim to quantify the association between radon progeny and lung cancer mortality in the largest and most up-to-date pooled study of uranium miners. METHODS: The pooled uranium miners analysis combines 7 cohorts of male uranium miners with 7754 lung cancer deaths and 4.3 million person-years of follow-up. Vital status and lung cancer deaths were ascertained between 1946 and 2014. The association between cumulative radon exposure in working level months (WLM) and lung cancer was modelled as the excess relative rate (ERR) per 100 WLM using Poisson regression; variation in the association by temporal and exposure factors was examined. We also examined analyses restricted to miners first hired before 1960 and with
- Published
- 2023