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Your search keyword '"Kressner, Ulf"' showing total 26 results
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26 results on '"Kressner, Ulf"'

2. Conversions in laparoscopic surgery for rectal cancer

Author

van der Pas, Martijn H. G. M., Deijen, Charlotte L., Abis, Gabor S. A., de Lange-de Klerk, Elly S. M., Haglind, Eva, Fürst, Alois, Lacy, Antonio M., Cuesta, Miguel A., Bonjer, Hendrik J., d’Hoore, André, Birch, Dan, DeGara, Chris, Jamieson, Chris, Peiman, Poornoroozy, Jensen, Karl Juul, Bulut, Orhan, Jess, Per, Rosenberg, Jacob, Harvald, Thomas, Ovesen, Henrik, Iesalnieks, Igors, Agha, Ayman, Jaeger, Christina, Kreis, Martin, Kasparek, Michael, Fürst, Alois, Liebig-Hoerl, Gudrun, Kim, Seon Hahn, Bonjer, Jaap, van der Peet, Donald, Cuesta, Miguel, van der Pas, Martijn, Buunen, Mark, Abis, Gabor, Deijen, Charlotte, de Lange-de Klerk, Elly, Hop, Wim, Neijenhuis, Peter, Coene, Peter Paul, van der Harst, Edwin, van ‘t Riet, Yvonne, Bemelman, Willem, Gerhards, Michael, Prins, Hubert, Targarona, Eduardo, Balague, Carmen, Martinez, Carmen, Osorio, Juan Franco, Molina, Garcia, Lacy, Antonio, Delgado, Salvadora, Lujan, Juan, Valero, Graciela, Alonso-Poza, Alfredo, Losadar, Manual, Argudo, Salvador, Lackberg, Zoltan, Skullman, Stefan, Kurlberg, Goran, Haglind, Eva, Andersson, John, Angenete, Eva, Ekelund, Jan, Kressner, Ulf, Matthiessen, Peter, and For the COLOR II study group

Published
2017
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8. Definition of candidate low risk APC alleles in a Swedish population

Author

Zhou, Xiao-Lei, Eriksson, Ulrika, Werelius, Barbro, Kressner, Ulf, Sun, Xiao-Feng, Lindblom, Annika, Zhou, Xiao-Lei, Eriksson, Ulrika, Werelius, Barbro, Kressner, Ulf, Sun, Xiao-Feng, and Lindblom, Annika

Abstract

Many families experience an apparently inherited increased risk of colorectal cancer (CRC) similar to the known syndromes familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). Besides these high-risk syndromes, approximately 10% of all CRC cases come from families with 2 affected 1st-degree relatives, and even 1st-degree relatives to a single case of CRC are at increased risk. Risk subjects from these families frequently show polyps at colonoscopy, which suggests the APC gene as a good candidate susceptibility gene for these attenuated polypotic syndromes. We used the sensitive DHPLC technique to search for possible predisposing germline mutations in the entire APC gene in 91 risk subjects from these high- and low-risk syndromes with unknown predisposing genes. Most exons were also screened for mutations in 96 normal controls and 96 colorectal cancer cases. In our study we probably have identified the most common APC variants in a Swedish population. Among 30 germline variants identified, 1 clearly pathogenic nonsense mutation and 11 putative pathogenic variants (10 missense and one 3′ UTR) were found in 20 index patients (22%). Twelve silent as well as 5 intronic variants were considered nonpathogenic. Two of the missense variants found here, E1317Q and D1822V, have previously been related to a difference in risk of colorectal cancer. One variant, 8636C>A, located within the 3′ UTR region of the APC gene, was suggested to constitute an additional low risk allele with a similar relative risk as the Jewish 11307K mutation (OR = 1.8, 9S% CI, 0.96-3.40). The question of whether all the other variants confer an increased colorectal cancer risk warrants future large association studies. © 2004 Wiley-Liss, Inc.

Published
2004
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9. Genes with Relevance for Early to Late Progression of Colon Carcinoma Based on Combined Genomic and Transcriptomic Information from the Same Patients

Author

Lagerstedt, Kristina K., primary, Kristiansson, Erik, additional, Lönnroth, Christina, additional, Andersson, Marianne, additional, IresjÖ, Britt-Marie, additional, Gustafsson, Annika, additional, Hansson, Elisabeth, additional, Kressner, Ulf, additional, Nordgren, Svante, additional, Enlund, Fredrik, additional, and Lundholm, Kent, additional

Published
2010
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20. Enzymatic Mutation Detection in the P53 Gene

Author

Inganäs, Mats, primary, Byding, Sara, primary, Eckersten, Ann, primary, Eriksson, Solveig, primary, Hultman, Tomas, primary, Jorsback, Anneli, primary, Löfman, Esfir, primary, Sabounchi, Fariba, primary, Kressner, Ulf, primary, Lindmark, Gudrun, primary, and Tooke, Nigel, primary

Published
2000
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23. Mutation analyses of KRAS exon 1 comparing three different techniques: temporal temperature gradient electrophoresis, constant denaturant capillaryelectrophoresis and allele specific polymerase chain reaction

Author

Bjørheim, Jens, primary, Lystad, Sigrid, additional, Lindblom, Annika, additional, Kressner, Ulf, additional, Westring, Sophia, additional, Wahlberg, Siobhan, additional, Lindmark, Gudrun, additional, Gaudernack, Gustav, additional, Ekstrøm, Per, additional, Røe, Janne, additional, Thilly, William G., additional, and Børresen-Dale, Anne-Lise, additional

Published
1998
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24. EP.

Author

Gustafsson, Annika, Hansson, Elisabeth, Kressner, Ulf, Nordgren, Svante, Andersson, Marianne, Wang, Wenhua, Lönnroth, Christina, and Lundholm, Kent

Abstract

The importance of prostaglandins in tumor growth and progression is well recognized, including antineoplastic activities by cyclooxygenase (COX) inhibitors. Variation in treatment response to COX inhibition has questioned differences in expression of cell surface and nuclear membrane receptors among tumors with different disease progression. The purpose of this study was to evaluate whether EP [ABSTRACT FROM AUTHOR]

Published
2007
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25. HIP FRACTURES IN WOMEN WITH BREAST CANCER

Author

ADAMI, HANS-OLOV, primary, ZACK, MATTHEW, additional, KRESSNER, ULF, additional, PERSSON, INGEMAR, additional, BERGLUND, AGNETA, additional, NAESSEN, TORD, additional, and BERGKVIST, LEIF, additional

Published
1990
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26. EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality.

Author

Gustafsson A, Hansson E, Kressner U, Nordgren S, Andersson M, Wang W, Lönnroth C, and Lundholm K

Subjects
Adult, Aged, Aged, 80 and over, Colorectal Neoplasms genetics, Colorectal Neoplasms metabolism, Cyclooxygenase 1 genetics, Cyclooxygenase 1 metabolism, Cyclooxygenase 2 genetics, Cyclooxygenase 2 metabolism, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Multivariate Analysis, PPAR gamma metabolism, Prognosis, Prostaglandin-Endoperoxide Synthases metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Receptors, Prostaglandin E metabolism, Receptors, Prostaglandin E, EP1 Subtype, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP3 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Reverse Transcriptase Polymerase Chain Reaction, Colorectal Neoplasms pathology, PPAR gamma genetics, Prostaglandin-Endoperoxide Synthases genetics, Receptors, Prostaglandin E genetics
Abstract

The importance of prostaglandins in tumor growth and progression is well recognized, including antineoplastic activities by cyclooxygenase (COX) inhibitors. Variation in treatment response to COX inhibition has questioned differences in expression of cell surface and nuclear membrane receptors among tumors with different disease progression. The purpose of this study was to evaluate whether EP(1-4) subtype, PPAR gamma receptor and COX-1/COX-2 expression in colorectal cancer are related to tumor-specific mortality. Reverse transcription-polymerase chain reaction and immunohistochemistry were used to demonstrate expression and protein appearance in tumor tissue compared with normal colon tissue. EP(1) and EP(2) subtype receptor protein was highly present in tumor cells, EP(3) occurred occasionally and EP(4) was not visible. PPAR gamma, EP(2) and EP(4) mRNA were significantly higher in normal colon tissue compared with tumor tissue, without any distinct relationship to Dukes A-D tumor stage. Multivariate analyses indicated that increased tumor tissue EP(2) and COX-2 expression predicted poor survival (p<0.001). COX-1 expression was significantly higher than COX-2 expression in normal colon tissue. Average COX-2 mRNA was not increased in tumor tissue compared with normal colon. However, most tumor cells stained positive for COX-2 protein, which was low or undetectable in normal mucosa cells. COX-1 protein was preferentially visible in stroma. EP(1-4) subtype receptor mRNAs were generally positively correlated to both COX-1 and COX-2 in tumor tissue, but not in normal colon. Our results imply that both prostaglandin production (COX-2) and signaling via EP(1-4) subtype receptors, particularly EP(2), predict disease-specific mortality in colorectal cancer., ((c) 2007 Wiley-Liss, Inc.)

Published
2007
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