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5. Changes in bodyweight after initiating antiretroviral therapy close to HIV-1 seroconversion: an international cohort collaboration

Author

Pantazis, Nikos, Sabin, Caroline A, Grabar, Sophie, Van der Valk, Marc, Jarrin, Inma, van Sighem, Ard, Meyer, Laurence, Carlander, Christina, Gill, John, Volny Anne, Alain, Spire, Bruno, Tariq, Shema, Burns, Fiona, Costagliola, Dominique, Ruiz-Burga, Elisa, Touloumi, Giota, Porter, Kholoud, Moreno, Santiago, Burns, Fiona, Campo, Rafael Eduardo, Garges, Harmony, Mussini, Cristina, Pantazis, Nikos, Kamel, Moustafa, Porter, Kholoud, Sabin, Caroline, Tariq, Shema, Touloumi, Giota, Vannappagari, Vani, Anne, Alain Volny, Young, Lital, Gill, John, Carlander, Christina, Grabar, Sophie, Jarrín, Inma, Meyer, Laurence, van der Valk, Marc, Wittkop, Linda, Aisam, Agnes, Barger, Diana, Davidovich, Udi, Dos Santos, Marie, Eriksson, Lars, Fitzgerald, Eli, Karakosta, Argyro, Krentz, Hartmut, Nicholls, Emily Jay, Policek, Nicoletta, Ruiz-Burga, Elisa, Sandford, Chris, Spire, Bruno, Suárez-García, Inés, Abgrall, Sophie, Andriantsoanirina, Valerie, Avettand-Fenoel, Veronique, Bourgeois, Christine, Chaix, Marie-Laure, Cheret, Antoine, Fischer, Hugues, Goujard, Cecile, Lascoux-Combe, Caroline, Le Palec, Annie, Petrov-Sanchez, Ventzlislava, Saez-Cirion, Asier, Seng, Remonie, Stefic, Karl, Tine, Josephine, Piet, E, Gagneux-Brunon, A, Jacomet, C, Piroth, L, Benezit, F, Goussef, M, Tattevin, P, Bani Sadr, B, Lamaury, I, Bazus, H, Robineau, O, Calin, R, Katlama, J, Denis, B, Ghosn, J, Joly, V, Khuong, M A, Caby, F C, Rouveix Nordon, E, de Truchis, P, Abgrall, S, Chéret, A, Duvivier, C, Becker, A, Miailhes, P, Abel, S, Unal, G, Makinson, A, Martin-Blondel, G, Morisot, A, Bregigeon, S, Enel, P, Allavena, C, Rabier, V, Vallet, L, Marchand, L, Saïdi, T, Costagliola, D, Grabar, S, Piet, E, Andriantsoanirina, V, Rabier, V, Fischer, H, Vallet, L, Marchand T Saïdi, L, Costagliola, D, Grabar, S, Abgrall, Sophie, Tattevin, Pierre, de Truchis, Pierre, Fischer, Hughes, Grabar, Sophie, Moreno, Santiago, Jarrín, Inma, Dalmau, David, Navarro, M Luisa, González, M Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, Muñoz-Fernández, M Ángeles, Adamis, G, Chini, M, Chrysos, G, Marangos, M, Katsarou, O, Kofteridis, D, Metallidis, S, Panagopoulos, P, Papadopoulos, A, Paparizos, V, Psychogiou, M, Sambatakou, H, Sipsas, N V, Touloumi, G, Fox, Julie, Terry, Louise, Waters, Anele, Uriel, Alison, Ustianowski, Andrew, Hackney, Pamela, Fahd, Niaz, Fidler, Sarah, Ayap, Wilbert, Molina, Marcelino, Waters, Laura, Nur, Fowsiya, Fernandez, Thomas, Nugent, Diarmuid, Pinedo, Javier, Reeves, Iain, Fong, Tracy, Nicholls, Jane, Cunningham, Laura, Pangan, Jaydee, Mackintosh, Claire, and Sharp, Louise

Abstract

Understanding the reasons for and consequences of bodyweight change in people living with HIV initiating antiretroviral therapy (ART) is crucial to optimising long-term health and wellbeing. We aimed to examine bodyweight trends and associated factors among individuals with well estimated dates of HIV-1 seroconversion.

Published
2024
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9. Retention Among North American HIV-Infected Persons in Clinical Care, 2000–2008

Author

Rebeiro, Peter, Althoff, Keri N, Buchacz, Kate, Gill, John, Horberg, Michael, Krentz, Hartmut, Moore, Richard, Sterling, Timothy R, Brooks, John T, Gebo, Kelly A, Hogg, Robert, Klein, Marina, Martin, Jeffrey, Mugavero, Michael, Rourke, Sean, Silverberg, Michael J, Thorne, Jennifer, and Gange, Stephen J

Subjects
Public Health, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, HIV/AIDS, Prevention, Infectious Diseases, Substance Misuse, Behavioral and Social Science, Sexually Transmitted Infections, Clinical Research, 8.1 Organisation and delivery of services, Good Health and Well Being, Adult, Anti-Retroviral Agents, Canada, Cohort Studies, Female, HIV Infections, Humans, Male, Middle Aged, Patient Compliance, Regression Analysis, Risk Factors, United States, retention, churn, HIV clinical care, North America, HRSA HAB, National HIV/AIDS Strategy, North American AIDS Cohort Collaboration on Research and Design, Public Health and Health Services, Virology, Clinical sciences, Epidemiology, Public health
Abstract

BackgroundRetention in care is key to improving HIV outcomes. The goal of this study was to describe 'churn' in patterns of entry, exit, and retention in HIV care in the United States and Canada.MethodsAdults contributing ≥1 CD4 count or HIV-1 RNA (HIV-lab) from 2000 to 2008 in North American AIDS Cohort Collaboration on Research and Design clinical cohorts were included. Incomplete retention was defined as lack of 2 HIV-laboratories (≥90 days apart) within 12 months, summarized by calendar year. Beta-binomial regression models were used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) of factors associated with incomplete retention.ResultsAmong 61,438 participants, 15,360 (25%) with incomplete retention significantly differed in univariate analyses (P < 0.001) from 46,078 (75%) consistently retained by age, race/ethnicity, HIV risk, CD4, antiretroviral therapy use, and country of care (United States vs. Canada). From 2000 to 2004, females (OR = 0.82, CI: 0.70 to 0.95), older individuals (OR = 0.78, CI: 0.74 to 0.83 per 10 years), and antiretroviral therapy users (OR = 0.61, CI: 0.54 to 0.68 vs. all others) were less likely to have incomplete retention, whereas black individuals (OR = 1.31, CI: 1.16 to 1.49, vs. white), those with injection drug use HIV risk (OR = 1.68, CI: 1.49 to 1.89, vs. noninjection drug use), and those in care longer (OR = 1.09, CI: 1.07 to 1.11 per year) were more likely to have incomplete retention. Results from 2005 to 2008 were similar.DiscussionFrom 2000 to 2008, 75% of the North American AIDS Cohort Collaboration on Research and Design population was consistently retained in care with 25% experiencing some changes in status or churn. In addition to the programmatic and policy implications, the findings of this study identify patient groups who may benefit from focused retention efforts.

Published
2013

13. Managing HIV infection in patients older than 50 years

Author

McMillan, Jacqueline M., Krentz, Hartmut, Gill, M. John, and Hogan, David B.

Subjects
United States. Centers for Disease Control and Prevention -- Management, Elderly patients -- Care and treatment, HIV patients -- Care and treatment, Highly active antiretroviral therapy, HIV infections -- Prevention -- Care and treatment, HIV -- Prevention -- Care and treatment, Antiretroviral agents, Company business management, Health
Abstract

Antiretroviral therapy has extended the life expectancy of people living with HIV, (1-4) although disparities remain. Patients who are not white, who begin antiretroviral therapy with CD4 cell counts below [...]

Published
2018
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16. Effect of Immediate Initiation of Antiretroviral Treatment in HIV-Positive Individuals Aged 50 Years or Older

Author

Lodi, Sara, Costagliola, Dominique, Sabin, Caroline, del Amo, Julia, Logan, Roger, Abgrall, Sophie, Reiss, Peter, van Sighem, Ard, Jose, Sophie, Blanco, Jose-Ramon, Hernando, Victoria, Bucher, Heiner C., Kovari, Helen, Segura, Ferran, Ambrosioni, Juan, Gogos, Charalambos A., Pantazis, Nikos, Dabis, Francois, Vandenhende, Marie-Anne, Meyer, Laurence, Seng, Rémonie, Gill, M. John, Krentz, Hartmut, Phillips, Andrew N., Porter, Kholoud, Grinsztejn, Beatriz, Pacheco, Antonio G., Muga, Roberto, Tate, Janet, Justice, Amy, and Hernán, Miguel A.

Published
2017
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26. Domestic violence screening: prevalence and outcomes in a Canadian HIV population

Author

Siemieniuk, Reed A.C., Krentz, Hartmut B., Gish, Jessica A., and Gill, M. John

Subjects
Victims of crimes -- Health aspects, Family violence -- Influence, HIV infection -- Risk factors, HIV infection -- Diagnosis, HIV infection -- Research, Health
Abstract

There is a strong association between domestic violence victimization and HIV infection. This may lead to poor health outcomes including mental health disorders and reduced access to care. A standardized domestic violence screening interview was incorporated into ongoing care in the large and diverse population living with HIV in Southern Alberta, Canada. Results from May through December 2009 are reported, including the prevalence and outcomes of abuse. Thirty-four percent of 853 patients screened reported abuse. Of these, 16% reported abuse in their current relationship, 58% in a previous relationship, and 57% reported a history of childhood abuse. High-risk groups for abuse included females (43%), gay/bisexual males (35%), and Aboriginals (61%). We found an association between a history of domestic violence and delayed access to care (p < 0.05), missed appointments (p < 0.001), and an increased use of clinic resources such as social work (p < 0.0001) and psychiatry (p DOI: 10.1089/apc.2010.0235

Published
2010

33. 2. Futile or Fertile? Lessons Learned from a Novel Geriatric Rehabilitation Curriculum

Author

Sider, Cody, Lee, Ben, Taneja, Karishma, Morgenstern, Jason, Evans, Alison, Naqvi, Raza, Brymer, Chris, Perrella, Andrew, Chau, Vicky, Cuperfain, Ari, Marshall, Cecelia, Tsokas, Mario, Chiu, Karen, Zhao, Qiannan, Sheng, Dade, Iaboni, Andrea, Radcliffe, Sarah, Giangregorio, Aidan, Ioannidis, George, Kennedy, Courtney, Lamarche, Larkin, Oliver, Doug, Dolovich, Lisa, Haney, Erin, Papioann, Alexandra, Franco, Bryan, Heckman, George, Dupuis, Sherry, Loiselle, Lisa, Boscart, Veronique, Lee, Linda, Sivarajah, Lavan, Borhan, ASM, Negm, Ahmed, Marr, Sharon, Patterson, Christopher, Misiaszek, Brian, Woo, Tricia, Papaioannou, Alexandra, Norman, Richard, Sinha, Samir, Cheung, Evelyn, Costa, Andrew, Osborne, Alyson, Kane, Sheri-Lynn, Burrell, Alishya, Chahine, Saad, Diachun, Laura, Goldlist, Kady, Ehrlich, April, Cioltan, Hannah Stocker, Wendel, Christopher, Pang, Rui Wen, Evans, Kevin, Mohler, Jane, Fain, Mindy, Bastron, Robert, Stanton, Mark, Reich, Krista, Tang, Andrew, Paget, Michael, McLaughlin, Kevin, Kwan, Emily, Chabot, Julia, Beauchet, Oliver, Fung, Shek, Peretz, Isabelle, Haque, Nihal, Dasgupta, Monidipa, von Maltzahn, Maia, Alston, Jillian, Stall, Nathan, Habeeb, Yaser, Gandell, Dov, Norris, Mireille, Liu, Barbara, Searle, Samuel, Rodger, Alison, Walsh, Steve, Nemiroff, Leah, Haroon, Babar, Rockwood, Kenneth, Klair, Amandeep Kiddy, Haddad, Taleen, Huang, Allen, Tharmalingam, Surenthar, Takaoka, Alyson, Shears, Melissa, Millen, Tina, Holding, Amanda, Clarke, France, Sean, Bagshaw, Li, Guowei, Cook, Deborah, Pieruccini-Faria, Frederico, Muir-Hunter, Susan, Fischer, Hadas, Fung, Kinwah, Bronskill, Susan, Austin, Peter, Matlow, Jeremy, Quinn, Kieran, Mitchell, Susan, Bell, Chaim, Rochon, Paula, Turner, Justin, Tannenbaum, Cara, Sathiyamoorthy, Thrmiga, Ali, Amanda, Kloseck, Marita, Lee, Justin, Muratov, Sergei, Tarride, Jean-Eric, Paterson, Michael, Gomes, Tara, Mbuagbaw, Lawrence, Thavorn, Kednapa, Khuu, Wayne, Holbrook, Anne, Nicholson, Kathryn, Terry, Amanda, Fortin, Martin, Williamson, Tyler, Thind, Amardeep, De Jesus, Marcos Barrera, Bhullar, Ashley, Tate, Robert, St. John, Philip, Torbiak, Lindsay, Tyas, Suzanne, Menec, Verena, Griffith, Lauren, St. John, Phillip, Watt, Jennifer, Crilly, Richard, Wong-Pack, Matthew, Ringer, Thom, Miller, Patricia, Sztramko, Richard, Vastis, Peter, Abu-Ghazaleh, Nadine, Abyad, Abdulrazak, Alibhai, Shabbir M. H., Loucks, Allison, Jin, Rana, Puts, Martine, Alsaad, Saad Mohammad, Brignardello-Petersen, Romina, Thabane, Lehana, Veroniki, Areti-Angeliki, Adachi, Rick, Richardson, Julie, Cameron, Ian, Bakouni, Hamzah, Vasiliadis, Helen-Maria, Basu, Monisha, Borrie, Michael, Morais, Jose, Hogan, David, Molnar, Frank, Fruetel, Karen, Beauchet, Olivier, Launay, Cyrille, Allali, Gilles, Chen, Szu-Yu Tina, Kushner-Kow, Janet, Yu, Sung-Hsun, Chu, Karen, Seifer, Colette, Chuen, Victoria, Prashad, Rashmi, Beker, Lyndsay, Schlegel, Kimberly, Coulter, Corinne, Davies, Jasmine, Whitlock, Jennifer, Gutmanis, Iris, Park, Grace, Garm, Antonina (Annette), Song, Xiaowei, Hammami, Sonia, Hajem, Said, Hammami, Mohamed, Yaich, Amine, Kechida, Malek, Klii, Rym, Kochtali, Ines, Peel, Alexandrea, Harkness, Karen, Berry, Elizabeth, Smith, Stuart, Ross, Heather, Haslam-Larmer, Lynn, Convery, Catherine, Crawford, Lindsay, Hubble, Gerry, Valleau, Ellen, Hewston, Patricia, Deshpande, Nandini, Ho, Joanne, Carayannopoulos, Kallirroi Laiya, Bukhari, Rida, Cameron, Colleen, Nagge, Jeff, Jantzi, Micaela, Hirdes, John, Giangregorio, Lora, Pickard, Laura, Adachi, Jonathan D., Dobbs, Bonnie, Charles, Lesley, Chan, Karenn, Jamieson, Jeffrey, Tian, Peter, Slayter, Jeremy, McGibbon, Chris, McCollum, Alexander, Yetman, Linda, Oakley, Heather, Gionet, Sharron, McCloskey, Rose, Jarrett, Pamela, Mumbere-Bamusemba, David, Morais, José, Breton, Marie Claude, Farrell, Barbara, Giguère, Anik, Laurin, Danielle, Morin, Michèle, Sirois, Caroline, Tourigny, André, Marcotte, Martine, Kröger, Edeltraut, Sirois, Marie-Josée, Carmichael, Pierre-Hugues, Reeve, Emily, Kouladjian, Lisa, Veillette, Nathalie, Émond, Marcel, Dionne, Clermont, Aubin, Michèle, Bélanger, Richard, Foldes-Busque, Guillaume, Guillaumie, Laurence, Pluye, Pierre, Ware, Mark, Kueper, Jacqueline K., Montero-Odasso, Manuel, Speechley, Mark, Lanoue, Derek, Byszewski, Anna, Parsons, Robert, Lee, Jennifer, Chen, Andrea, Locklin, Jason, Patel, Tejal, Slonim, Karen, Hillier, Loretta M., Donaldson, Lindsay, Linda, Linda, Hillier, Loretta, McDermott, Miranda, Legere, Laura, McNeill, Susan, Blain, Julie, Lam, Robert, Rey, Michelle, Lemay, Geneviève, Leblond, Sara, Antoun, Thérèse, Carreau, Louise, Bouattane, El Moustafa, Joanisse, John, Lessard, Linda, Filion, Mélanie, Lesley, Charles, Parmar, Jasneet, Bremault-Phillips, Suzette, Lori, Sacry, Bryan, Slugett, Lew, Brendan, Keller, Denise, Ho, Joanne M.W., Parker, Shelley, Zeh, Wendy, Wong, Ken, Tsang, Ada, Contreras, Jesika, Ryan, David, Schwartz, Rhonda, Straus, Sharon, Liu, Barbara A., Jackson, Linda, Scarfone, Valerie, Madden, Kenneth, Cuff, Darcye, Meneilly, Graydon, Mah, Jasmine, Rhee, Glara Gaeun, Peel, Jacinta, Rocker, Adam, Weiss, Daniel, Tsang, Phillip, Mah, Greta, Chu, Patrick, Chan, Gabriel, Mandas, Roula, Olanubi, Timmy, Lum, Marlene, Heitner, Renee, Dellaposta, Felina, McGeachie, Mary Ellen, Chu, Dominic, Chang, Feng, McCormack, Norma, Woollard, Susan, McMillan, Jacqueline, Gill, John, Krentz, Hartmut, Mehta, Nishila, Rodrigues, Craig, Lamba, Manpreet, Wu, Wei, Herrmann, Nathan, Gill, Sudeep, Chan, An Wen, Mason, Robin, Day, Suzanne, Milan, Raymond, Berbich, Djamal, Naglie, Gary, Sanford, Sarah, Bédard, Michel, Tuokko, Holly, Mazer, Barbara, Porter, Michelle, Moorhouse, Paige, Polgar, Jan, Rapoport, Mark J., Naqvi, Syed, Dawood, Ryhana, O’Neill, Meagan, Mina, Daniel Santa, Sabiston, Catherine, Tomlinson, George, O’Donnell, Denis, Hazzan, Afeez A., Navare, Hrishi, Broadhurst, Daphne, Simpson, Diane, Loeb, Mark, Bon, Trevor, Plotnikov, Galina, Gorelic, Oleg, Bracha, Lior, Tishler, Moshe, Izhakian, Shimon, Prorok, Jeanette, McMillan, Colleen, Oremus, Mark, Stolee, Paul, Rosario, Carla, Jang, Raymond, Bezjak, Andrea, Yokom, Daniel, Alibhai, Shabbir M.H., Rozanski, Gabriela, Tang, Ada, Gourlay, Julie, Jack, Kelsey, Nowak, Christina, Sattar, Schroder, Spoelstra, Sandra, Bethell, Jennifer, Andrew, Melissa, Ayala, Ana Patricia, Ploeg, Jenny, Deangelis, Carlo, Elliott, Jacobi, Frank, Chris, Sidani, Souraya, McGilton, Katherine, Schuck, Sheena, Truter, Karen, Peters, Kayleen, Scotchmer, Emma, Sekhon, Harmehr, Skrastins, Emily, Ishigami, Yoko, Kirkland, Susan, Barhoumi, Amel, Robert, Tate, Lauren, Griffith, Thébeau, Annette, Tessier, Daniel, Trottier, Lise, Tran, Hang, Pereira, José, Teeple, Lori, Downer, Kathryn, Varughese, Jobin, Marcella, Jill, David, Henderson, Mary-Lou, Kelley, Robert, Benoît, Drake, Colleen, Grossman, Daphna, Vasudev, Akshya, Forchuk, Cheryl, Burhan, Amer, Booth, Richard, Hoch, Jeff, Isaranuwatchai, Wanrudee, Rudnick, Abraham, Seth, Puneet, Flint, Alistair, Rej, Soham, Reiss, Jeffrey, Von Maltzahn, Maia, Wong, Camilla, Tanzini, Rosa Maria, Gulasingam, Pauline, Cheng, Susanna, Haq, Rashida, Yang, Samantha, Johnson, Keia, Sheiban, Linda, Yu, Maggie Yongci, Jeffs, Lianne, Yung, Donald, Ewa, Vivian, and Turley, Nathan

Subjects
Abstracts, Geriatrics and Gerontology, Gerontology
Published
2017
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34. sj-pdf-1-std-10.1177_0956462420945948 - Supplemental material for Missed opportunities within healthcare for an earlier diagnosis of HIV

Author

Powell, Maria, Krentz, Hartmut B, Eagles, Matthew E, and M John Gill

Subjects
110309 Infectious Diseases, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-std-10.1177_0956462420945948 for Missed opportunities within healthcare for an earlier diagnosis of HIV by Maria Powell, Hartmut B Krentz, Matthew E Eagles and M John Gill in International Journal of STD & AIDS

Published
2020
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39. Uptake Success and Cost Savings from Switching to a Two-Drug Antiretroviral Regimen.

Author

Krentz, Hartmut B., Campbell, Shayna, Lahl, Morgan, and Gill, M. John

Subjects
*THERAPEUTICS, *HIV infections, *HIV-positive persons, *MEDICAL quality control, *PATIENT aftercare, *COMBINATION drug therapy, *HIV integrase inhibitors, *COST control, *RETROSPECTIVE studies, *DRUG resistance, *PATIENTS' attitudes, *TREATMENT effectiveness, *LAMIVUDINE, *DESCRIPTIVE statistics, *PATIENT safety
Abstract

The emergence of dual therapy for antiretroviral (ARV)-experienced persons living with HIV (PWH) offers the opportunity to reduce lifetime exposure to unnecessary ARV drugs while maintaining viral suppression and reducing the cost of care. Our objective, using retrospective analysis of a quality care initiative, was to examine in routine clinical practice the clinical impact of switching PWH stable on a three-drug to a two-drug single-tablet formulation (STF) ARV regimen. We also examined the cost implications of this STF adjustment. Between January 1, 2020 and January 1, 2021 eligible patients (i.e., virally suppressed, no active hepatitis B infection, no documented nucleoside reverse transcriptase inhibitors/integrase strand transfer inhibitor resistance) were offered, on a convenience basis and as part of routine care, the opportunity to adjust their current three-drug STF to a two-drug STF (dolutegarvair/lamivudine). The acceptance, clinical efficacy, safety, tolerability, and cost of treatment were measured for patients who switched in 2020. Of 989 eligible PWH, 408 were approached and 391 (39.5%) switched to two-drug regimen; 99% remained on the two-drug STF at year's end (median 240 days follow-up). Only 2/391 patients who switched lost viral control. The total ARV drug cost for all 989 patients decreased by 10.3% generating an actual savings of $1,596,666 among patients approached and switched in 2020. Patient interest and uptake in switching to two-drug STF was substantial and resulted in few discontinuations for any reason. It provided significant and immediate cost savings within the first year. Our results bring clarity to discussions on whether using two-drug regimens would be practical and acceptable in nonclinical trial settings. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS

Author

Krentz Hartmut B, Siemieniuk Reed A, Vivithanaporn Pornpun, Lee Kathy, Maingat Ferdinand, Gill M John, and Power Christopher

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Anti-epileptic drugs (AEDs) are frequently prescribed to persons with HIV/AIDS receiving combination antiretroviral therapy (cART) although the extent of AED use and their interactions with cART are uncertain. Herein, AED usage, associated toxicities and immune consequences were investigated. Methods HIV replication was analysed in proliferating human T cells during AED exposure. Patients receiving AEDs in a geographically-based HIV care program were assessed using clinical and laboratory variables in addition to assessing AED indication, type, and cumulative exposures. Results Valproate suppressed proliferation in vitro of both HIV-infected and uninfected T cells (p <0.05) but AED exposures did not affect HIV production in vitro. Among 1345 HIV/AIDS persons in active care between 2001 and 2007, 169 individuals were exposed to AEDs for the following indications: peripheral neuropathy/neuropathic pain (60%), seizure/epilepsy (24%), mood disorder (13%) and movement disorder (2%). The most frequently prescribed AEDs were calcium channel blockers (gabapentin/pregabalin), followed by sodium channel blockers (phenytoin, carbamazepine, lamotrigine) and valproate. In a nested cohort of 55 AED-treated patients receiving cART and aviremic, chronic exposure to sodium and calcium channel blocking AEDs was associated with increased CD4+ T cell levels (p <0.05) with no change in CD8+ T cell levels over 12 months from the beginning of AED therapy. Conclusions AEDs were prescribed for multiple indications without major adverse effects in this population but immune status in patients receiving sodium or calcium channel blocking drugs was improved.

Published
2010
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48. Additional file 1: of Increasing incidence of syphilis among patients engaged in HIV care in Alberta, Canada: a retrospective clinic-based cohort study

Author

Raynell Lang, Read, Ron, Krentz, Hartmut, Ramazani, Soheil, Mingkai Peng, Gratrix, Jennifer, and M. Gill

Abstract

Table S1. Characteristics of HIV+ patients regularly followed at the Southern Alberta Clinic between 1/1/2006 and 12/31/2016 comparing patients in four groups: syphilis positive (reference group), repeat syphilis positive, syphilis positive not on ART, syphilis positive not HIV Virologically suppressed (VL > 40 copies/mL). 1Indigenous includes Aboriginal, Metis and Inuit; ACB includes African, Caribbean, Black; Other includes IndoAsian, Hispanic, East Asian, and other. 2MSM = self-reported men who have sex with men identification; HET = self-reported heterosexual identification; PWID = self-reported intravenous drug use identification; Other HIV Risk factor behavior includes: blood transfusions, hemophiliac, neonatal, postnatal infection, unknown or not reported. 3History of Cigarette Smoking-Current or Past; History of Alcohol Abuse- > 14 drinks/week or binge drinking; History of Recreational Drug Use –Current or Past; History of Intimate Partner Violence-Current or Past. (DOCX 24 kb)

Published
2018
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50. Reporting on patients living with HIV "disengaging from care". Who is actually "lost to follow-up"?

Author

Krentz, Hartmut B., McPhee, Paul, Arbess, Gordon, Jackson, Linda, Stewart, Ann M., Bois, Daniel, and Rourke, Sean B.

Subjects
*DIAGNOSIS of HIV infections, *CONTINUUM of care, *HEALTH promotion, *HEALTH status indicators, *HIV-positive persons, *HOSPITALS, *PATIENT compliance, *PATIENT monitoring, *DISEASE management, *PATIENTS' attitudes
Abstract

Retention in care remains an important concern for health care providers. However, accurately identifying who is or is not retained in care can be problematic. Not all patients believed to be engaged in care are actually in care, and not all patients believed to be disengaged are truly disengaged. Identifying the status of individuals within populations is important for clinical, administrative and surveillance concerns. As part of the Linkage and Retention in Care Project at St Michael's Hospital in Toronto, Canada, we investigated the status of patients diagnosed with HIV. Detailed investigation determined who was actually Lost-to-Follow-Up (i.e., disengaged from care >12 months) and who had disengaged for known reasons. This approach determined more precisely who was currently followed in care and who was not, and to target efforts to contact and reengage patients more effectively. This study illustrates the importance of accurately monitoring populations enhancing disease management. [ABSTRACT FROM AUTHOR]

Published
2021
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