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1. Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial

Author

Bankundiye, Gloriose, Boyd Barr, Dana, Burrowes, Vanessa, Bussalleu, Alejandra, Campbell, Devan, Canuz, Eduardo, Castañaza, Adly, Clark, Maggie, Crocker, Mary, De León, Oscar, Dusabimana, Ephrem, Elon, Lisa, Espinoza, Juan G, Pineda Fuentes, Irma, Ghosh, Ahana, Goodman, Dina, Gupton, Savannah, Hamid, Sarah, Harvey, Steven, Hengstermann, Mayari, Hennessee, Ian, Herrera, Phabiola, Howard, Marjorie, Howards, Penelope P., Jaacks, Lindsay, Kearns, Katherine, Kremer, Jacob, Laws, Margaret A., Lenzen, Pattie, Liao, Jiawen, Lovvorn, Amy, Mbabazi, Jane, McPeek, Julia N., Meyers, Rachel, Miranda, J. Jaime, Mollinedo, Erick, Monroy, Libny, Mukhopadhyay, Krishnendu, Mutariyani, Bernard, Naeher, Luke P., Nambajimana, Abidan, Natesan, Durairaj, Nizam, Azhar, Ntivuguruzwa, Jean de Dieu, Piedrahita, Ricardo, Puttaswamy, Naveen, Puzzolo, Elisa, Quinn, Ashlinn, Rajamani, Karthikeyan D., Rajkumar, Sarah, Ramasami, Rengaraj, Ramirez, Alexander, Ryan, P. Barry, Saidam, Sudhakar, Sakas, Zoe, Sambandam, Sankar, Sarnat, Jeremy, Smith, Kirk, Swearing, Damien, Toenjes, Ashley, Underhill, Lindsay, Uwizeyimana, Jean D, Valdes, Viviane, Verma, Amit, Warnock, Megan, Ye, Wenlu, Young, Bonnie, Younger, Ashley, Monroy-Alarcón, Libny Y., Castañaza Gonzalez de Durante, Adly, López-Ortega, Claudia, Gonzalez, Maria F., Sowrirajan, Lakshminarayanan, Paramanandam, Shanthi P., Shanmugavadivu, K, Sudharsanan, V, Seshadri, Suresh, Yupanqui-Fredes, Adhemir E., Hancco-Gomez, Mario, Apaza, Ronald, Persivale-Calle, Juan F., Quispe, Elizabeth, Leon-Ponce, Carlos, Villar-Gonzales, Victor, Andrade-Salas, Rebeca, Herrera, Jhon E., Ramos-Mamani, Luzdelia, Lopez, Yessica, Quiza, Giovanna, Hinojosa, Yadel, Gomez-Quispe, Madeluz, Frisancho-Parada, Gery, Mendoza-Apaza, Danielle I., Quispe-Flores, Luz R., Xavier, Niyitegeka F, Utfimana, Grace, Tuzayisenga, Elie, Nkurunziza, Valens, Checkley, William, Thompson, Lisa M, Hossen, Shakir, Nicolaou, Laura, Williams, Kendra N, Hartinger, Stella M, Chiang, Marilu, Balakrishnan, Kalpana, Garg, Sarada S, Thangavel, Gurusamy, Aravindalochanan, Vigneswari, Rosa, Ghislaine, Mukeshimana, Alexie, Ndagijimana, Florien, McCracken, John P, Diaz-Artiga, Anaité, Sinharoy, Sheela S, Waller, Lance, Wang, Jiantong, Jabbarzadeh, Shirin, Chen, Yunyun, Steenland, Kyle, Kirby, Miles A, Ramakrishnan, Usha, Johnson, Michael, Pillarisetti, Ajay, McCollum, Eric D, Craik, Rachel, Ohuma, Eric O, Dávila-Román, Victor G, de las Fuentes, Lisa, Simkovich, Suzanne M, Peel, Jennifer L, Clasen, Thomas F, and Papageorghiou, Aris T

Published
2024
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2. Exposure–response relationships for personal exposure to fine particulate matter (PM2·5), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial

Author

Balakrishnan, Kalpana, Steenland, Kyle, Clasen, Thomas, Chang, Howard, Johnson, Michael, Pillarisetti, Ajay, Ye, Wenlu, Naeher, Luke P, Diaz-Artiga, Anaite, McCracken, John P, Thompson, Lisa M, Rosa, Ghislaine, Kirby, Miles A, Thangavel, Gurusamy, Sambandam, Sankar, Mukhopadhyay, Krishnendu, Puttaswamy, Naveen, Aravindalochanan, Vigneswari, Garg, Sarada, Ndagijimana, Florien, Hartinger, Stella, Underhill, Lindsay J, Kearns, Katherine A, Campbell, Devan, Kremer, Jacob, Waller, Lance, Jabbarzadeh, Shirin, Wang, Jiantong, Chen, Yunyun, Rosenthal, Joshua, Quinn, Ashlinn, Papageorghiou, Aris T, Ramakrishnan, Usha, Howards, Penelope P, Checkley, William, and Peel, Jennifer L

Published
2023
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3. Comparing Performance and Reliability of Collocated Enhanced Children's MicroPEM (ECM) on Gravimetric and Nephelometric PM2.5 Personal Exposure Samples in Field Measurements in Rural Guatemala.

Author

Mollinedo, Erick, McCracken, John P., Johnson, Michael, Piedrahita, Ricardo, Pillarisetti, Ajay, Waller, Lance A., Wang, Jiantong, Thompson, Lisa M., Diaz-Artiga, Anaite, de Leon, Oscar, Ramirez, Alexander, Polanco, Alejandro, Campbell, Devan, Kearns, Katherine A., Kremer, Jacob, Nicolaou, Laura, Clark, Maggie L., Balakrishnan, Kalpana, Rosa, Ghislaine, and Peel, Jennifer L.

Subjects
AIR pollution measurement, STANDARD deviations, INTRACLASS correlation, PARTICULATE matter, GRAVIMETERS (Geophysical instruments)
Abstract

Traditional gravimetric instruments used for personal air pollution exposure measurements are often cumbersome and noisy and do not offer real‐time assessment capability. The Enhanced Children's MicroPEM (ECM) is a comparatively lightweight and quiet instrument designed to capture both integrated filter‐based gravimetric samples and real‐time continuous (nephelometric) particulate matter with an aerodynamic diameter of 2.5 μm or less (PM2.5) concentrations. We assessed the performance and reliability of collocated ECMs in a subset of pregnant women participating in a randomized controlled trial in Guatemala to test a liquefied petroleum gas (LPG) cookstove (intervention) versus biomass (control) for cooking. We compared average daily (24 h) PM2.5 concentrations for the paired gravimetric (n = 219) and paired adjusted nephelometric (n = 221) samples using Spearman correlation and Bland–Altman agreement; we also assessed reliability based on the intraclass correlation coefficient (ICC) and root mean square error (RMSE). Median PM2.5 gravimetric concentrations were 93.5 μg/m3 (interquartile range (IQR) = 52.6–160.5) and 21.4 μg/m3 (IQR = 12.0–32.0) in the control and LPG intervention groups, respectively; the median adjusted nephelometric concentrations were 83.7 μg/m3 (IQR = 47.6–148.9) and 22.6 μg/m3 (IQR = 17.5–29.7) in the control and LPG groups, respectively. Spearman correlations were higher in the control arm (0.91) than in the LPG intervention arm (0.67) in the gravimetric comparisons. The same trend was observed for adjusted nephelometric measurements in the control (0.92) and intervention arms (0.75). ICC values were high in both gravimetric (0.93) and nephelometric (0.95) collocations. Small differences in RMSE were observed for the gravimetric (26.69 μg/m3) and nephelometric collocations (31.76 μg/m3). Our findings demonstrate strong reliability between collocated ECMs for both gravimetric and adjusted nephelometric PM2.5 personal exposure samples in rural Guatemala. Trial Registration: ClinicalTrials.gov identifier: NCT02944682 [ABSTRACT FROM AUTHOR]

Published
2025
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4. Exposure Contrasts of Women Aged 40–79 Years during the Household Air Pollution Intervention Network Randomized Controlled Trial

Author

Ye, Wenlu, Campbell, Devan, Johnson, Michael, Balakrishnan, Kalpana, Peel, Jennifer L., Steenland, Kyle, Underhill, Lindsay J., Rosa, Ghislaine, Kirby, Miles A., Díaz-Artiga, Anaité, McCracken, John, Thompson, Lisa M., Clark, Maggie L., Waller, Lance A., Chang, Howard H., Wang, Jiantong, Dusabimana, Ephrem, Ndagijimana, Florien, Sambandam, Sankar, Mukhopadhyay, Krishnendu, Chiang, Marilu, Hartinger, Stella M, Nicolaou, Laura, Williams, Kendra, Piedrahita, Ricardo, Kearns, Katherine A., Kremer, Jacob, Ghosh, Ahana, Rosenthal, Joshua P., Checkley, William, Clasen, Thomas, Naeher, Luke, and Pillarisetti, Ajay

Abstract

Exposure to household air pollution has been linked to adverse health outcomes among women aged 40–79. Little is known about how shifting from biomass cooking to a cleaner fuel like liquefied petroleum gas (LPG) could impact exposures for this population. We report 24-h exposures to particulate matter (PM2.5), black carbon (BC), and carbon monoxide (CO) among women aged 40 to <80 years participating in the Household Air Pollution Intervention Network trial. 209 participants were randomized to the intervention and received an LPG stove and continuous fuel supply; controls used biomass (n= 209). Exposures were measured up to six times; we used mixed-effects models to estimate differences between intervention and control groups. Preintervention exposures between groups were comparable; median postintervention exposures were 62% (76.3 vs 29.3 μg/m3), 73% (10.4 vs 2.8 μg/m3), and 57% (1.4 vs 0.6 ppm) lower for PM2.5, BC, and CO among LPG users than for controls. Reductions were similar across countries; 70% of PM2.5exposures after intervention were below the annual WHO interim target I (IT-1) value of 35 μg/m3. We provide evidence that implementing an LPG intervention can reduce air pollution exposure over an 18-month period to at or below the annual WHO IT-1 guideline.

Published
2025
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6. Factors Determining Black Carbon Exposures among Pregnant Women Enrolled in the HAPIN Trial

Author

Campbell, Devan A., primary, Johnson, Michael, additional, Piedrahita, Ricardo, additional, Pillarisetti, Ajay, additional, Waller, Lance A., additional, Kearns, Katherine A., additional, Kremer, Jacob, additional, Mollinedo, Erick, additional, Sarnat, Jeremy A., additional, Clark, Maggie L., additional, Underhill, Lindsay J., additional, McCracken, John P., additional, Diaz-Artiga, Anaité, additional, Steenland, Kyle, additional, Rosa, Ghislaine, additional, Kirby, Miles A., additional, Balakrishnan, Kalpana, additional, Sambandam, Sankar, additional, Mukhopadhyay, Krishnendu, additional, Sendhil, Saritha, additional, Natarajan, Amudha, additional, Ndagijimana, Florien, additional, Dusabimana, Ephrem, additional, Thompson, Lisa M., additional, Checkley, William, additional, Nicolaou, Laura, additional, Hartinger, Stella, additional, Peel, Jennifer L., additional, Clasen, Thomas F., additional, and Naeher, Luke P., additional

Published
2024
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7. Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial

Author

Checkley, William, primary, Thompson, Lisa M, additional, Hossen, Shakir, additional, Nicolaou, Laura, additional, Williams, Kendra N, additional, Hartinger, Stella M, additional, Chiang, Marilu, additional, Balakrishnan, Kalpana, additional, Garg, Sarada S, additional, Thangavel, Gurusamy, additional, Aravindalochanan, Vigneswari, additional, Rosa, Ghislaine, additional, Mukeshimana, Alexie, additional, Ndagijimana, Florien, additional, McCracken, John P, additional, Diaz-Artiga, Anaité, additional, Sinharoy, Sheela S, additional, Waller, Lance, additional, Wang, Jiantong, additional, Jabbarzadeh, Shirin, additional, Chen, Yunyun, additional, Steenland, Kyle, additional, Kirby, Miles A, additional, Ramakrishnan, Usha, additional, Johnson, Michael, additional, Pillarisetti, Ajay, additional, McCollum, Eric D, additional, Craik, Rachel, additional, Ohuma, Eric O, additional, Dávila-Román, Victor G, additional, de las Fuentes, Lisa, additional, Simkovich, Suzanne M, additional, Peel, Jennifer L, additional, Clasen, Thomas F, additional, Papageorghiou, Aris T, additional, Bankundiye, Gloriose, additional, Boyd Barr, Dana, additional, Burrowes, Vanessa, additional, Bussalleu, Alejandra, additional, Campbell, Devan, additional, Canuz, Eduardo, additional, Castañaza, Adly, additional, Clark, Maggie, additional, Crocker, Mary, additional, De León, Oscar, additional, Dusabimana, Ephrem, additional, Elon, Lisa, additional, Espinoza, Juan G, additional, Pineda Fuentes, Irma, additional, Ghosh, Ahana, additional, Goodman, Dina, additional, Gupton, Savannah, additional, Hamid, Sarah, additional, Harvey, Steven, additional, Hengstermann, Mayari, additional, Hennessee, Ian, additional, Herrera, Phabiola, additional, Howard, Marjorie, additional, Howards, Penelope P., additional, Jaacks, Lindsay, additional, Kearns, Katherine, additional, Kremer, Jacob, additional, Laws, Margaret A., additional, Lenzen, Pattie, additional, Liao, Jiawen, additional, Lovvorn, Amy, additional, Mbabazi, Jane, additional, McPeek, Julia N., additional, Meyers, Rachel, additional, Miranda, J. Jaime, additional, Mollinedo, Erick, additional, Monroy, Libny, additional, Mukhopadhyay, Krishnendu, additional, Mutariyani, Bernard, additional, Naeher, Luke P., additional, Nambajimana, Abidan, additional, Natesan, Durairaj, additional, Nizam, Azhar, additional, Ntivuguruzwa, Jean de Dieu, additional, Piedrahita, Ricardo, additional, Puttaswamy, Naveen, additional, Puzzolo, Elisa, additional, Quinn, Ashlinn, additional, Rajamani, Karthikeyan D., additional, Rajkumar, Sarah, additional, Ramasami, Rengaraj, additional, Ramirez, Alexander, additional, Ryan, P. Barry, additional, Saidam, Sudhakar, additional, Sakas, Zoe, additional, Sambandam, Sankar, additional, Sarnat, Jeremy, additional, Smith, Kirk, additional, Swearing, Damien, additional, Toenjes, Ashley, additional, Underhill, Lindsay, additional, Uwizeyimana, Jean D, additional, Valdes, Viviane, additional, Verma, Amit, additional, Warnock, Megan, additional, Ye, Wenlu, additional, Young, Bonnie, additional, Younger, Ashley, additional, Monroy-Alarcón, Libny Y., additional, Castañaza Gonzalez de Durante, Adly, additional, López-Ortega, Claudia, additional, Gonzalez, Maria F., additional, Sowrirajan, Lakshminarayanan, additional, Paramanandam, Shanthi P., additional, Shanmugavadivu, K, additional, Sudharsanan, V, additional, Seshadri, Suresh, additional, Yupanqui-Fredes, Adhemir E., additional, Hancco-Gomez, Mario, additional, Apaza, Ronald, additional, Persivale-Calle, Juan F., additional, Quispe, Elizabeth, additional, Leon-Ponce, Carlos, additional, Villar-Gonzales, Victor, additional, Andrade-Salas, Rebeca, additional, Herrera, Jhon E., additional, Ramos-Mamani, Luzdelia, additional, Lopez, Yessica, additional, Quiza, Giovanna, additional, Hinojosa, Yadel, additional, Gomez-Quispe, Madeluz, additional, Frisancho-Parada, Gery, additional, Mendoza-Apaza, Danielle I., additional, Quispe-Flores, Luz R., additional, Xavier, Niyitegeka F, additional, Utfimana, Grace, additional, Tuzayisenga, Elie, additional, and Nkurunziza, Valens, additional

Published
2024
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8. Post-birth exposure contrasts for children during the Household Air Pollution Intervention Network randomized controlled trial

Author

Pillarisetti, Ajay, primary, Ye, Wenlu, additional, Balakrishnan, Kalpana, additional, Rosa, Ghislaine, additional, Díaz-Artiga, Anaité, additional, Underhill, Lindsay J., additional, Steenland, Kyle, additional, Peel, Jennifer L., additional, Kirby, Miles A., additional, McCracken, John, additional, Waller, Lance, additional, Chang, Howard, additional, Wang, Jiantong, additional, Dusabimana, Ephrem, additional, Ndagijimana, Florien, additional, Sambandam, Sankar, additional, Mukhopadhyay, Krishnendu, additional, Kearns, Katherine A., additional, Campbell, Devan, additional, Kremer, Jacob, additional, Rosenthal, Joshua, additional, Ghosh, Ahana, additional, Clark, Maggie, additional, Checkley, William, additional, Clasen, Thomas, additional, Naeher, Luke, additional, Piedrahita, Ricardo, additional, and Johnson, Michael, additional

Published
2023
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9. Associations between pre-natal exposures to fine particulate matter (PM2.5), carbon monoxide, and black carbon and birthweight in the multi-country Household Air Pollution Intervention Network (HAPIN) trial

Author

Balakrishnan, Kalpana, primary, Steenland, Kyle, additional, Clasen, Thomas, additional, Chang, Howard, additional, Johnson, Michael, additional, Pillarisetti, Ajay, additional, Naeher, Luke, additional, Rosa, Ghislaine, additional, Kirby, Miles, additional, Diaz-Artiga, Anaite, additional, McCracken, John, additional, Thompson, Lisa, additional, Thangavel, Gurusamy, additional, Sambandam, Sankar, additional, Mukhopadhyay, Krishnendu, additional, Puttaswamy, Naveen, additional, Aravindalochanan, Vigneswari, additional, Garg, Sarada, additional, Hartinger, Stella, additional, Underhill, Lindsay, additional, Ndagijimana, Florien, additional, Kearns, Katherine, additional, Campbell, Devan, additional, Kremer, Jacob, additional, Waller, Lance, additional, Jabbarzadeh, Shirin, additional, Wang, Jean, additional, Chen, Yunyun, additional, Papageorghiou, Aris, additional, Howards, Penelope, additional, Ramakrishnan, Usha, additional, Rosenthal, Joshua, additional, Checkley, William, additional, and Peel, Jennifer, additional

Published
2022
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10. Resources and Geographic Access to Care for Severe Pediatric Pneumonia in Four Resource-limited Settings

Author

Simkovich, Suzanne M., primary, Underhill, Lindsay J., additional, Kirby, Miles A., additional, Crocker, Mary E., additional, Goodman, Dina, additional, McCracken, John P., additional, Thompson, Lisa M., additional, Diaz-Artiga, Anaité, additional, Castañaza-Gonzalez, Adly, additional, Garg, Sarada S., additional, Balakrishnan, Kalpana, additional, Thangavel, Gurusamy, additional, Rosa, Ghislaine, additional, Peel, Jennifer L., additional, Clasen, Thomas F., additional, McCollum, Eric D., additional, Checkley, William, additional, Aravindalochanan, Vigneswari, additional, Barr, Dana B., additional, Burrowes, Vanessa, additional, Campbell, Devan, additional, Canuz, Eduardo, additional, Chang, Howard, additional, Chen, Yunyun, additional, Chiang, Marilú, additional, Clark, Maggie L., additional, Craik, Rachel, additional, Dávila-Román, Victor, additional, Fuentes, Lisa de las, additional, Léon, Oscar De, additional, Dusabimana, Ephrem, additional, Elon, Lisa, additional, Espinoza, Juan Gabriel, additional, Fuentes, Irma S. Pineda, additional, Gupton, Savannah, additional, Hardison, Meghan, additional, Hartinger, Stella, additional, Harvey, Steven A., additional, Hengstermann, Mayari, additional, Herrera, Phabiola, additional, Hossen, Shakir, additional, Howards, Penelope, additional, Jaacks, Lindsay, additional, Jabbarzadeh, Shirin, additional, Johnson, Michael A., additional, Jones, Abigail, additional, Kearns, Katherine, additional, Kremer, Jacob, additional, Laws, Margaret, additional, Lenzen, Patricia M., additional, Liao, Jiawen, additional, Lovvorn, Amy, additional, Majorin, Fiona, additional, McPeek, Julia, additional, Meyers, Rachel M., additional, Miranda, J. Jaime, additional, Mollinedo, Erick, additional, Moulton, Lawrence, additional, Mukhopadhyay, Krishnendu, additional, Naeher, Luke, additional, Nambajimana, Abidan, additional, Ndagijimana, Florien, additional, Nizam, Azhar, additional, Ntivuguruzwa, Jean de Dieu, additional, Papageorghiou, Aris, additional, Piedrahita, Ricardo, additional, Pillarisetti, Ajay, additional, Puttaswamy, Naveen, additional, Puzzolo, Elisa, additional, Quinn, Ashlinn, additional, Rajkumar, Sarah, additional, Ramakrishnan, Usha, additional, Reardon, Davis, additional, Rosenthal, Joshua, additional, Ryan, P. Barry, additional, Sakas, Zoe, additional, Sambandam, Sankar, additional, Sarnat, Jeremy, additional, Sinharoy, Sheela, additional, Smith, Kirk R., additional, Steenland, Kyle, additional, Swearing, Damien, additional, Toenjes, Ashley K., additional, Uwizeyimana, Jean Damascene, additional, Valdes, Viviane, additional, Verma, Amit, additional, Waller, Lance, additional, Warnock, Megan, additional, Williams, Kendra, additional, Ye, Wenlu, additional, and Young, Bonnie, additional

Published
2022
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12. Exposure contrasts of pregnant women during the Household Air Pollution Intervention Network randomized controlled trial

Author

Johnson, Michael, primary, Pillarisetti, Ajay, additional, Piedrahita, Ricardo, additional, Balakrishnan, Kalpana, additional, Peel, Jennifer L., additional, Steenland, Kyle, additional, Underhill, Lindsay J., additional, Rosa, Ghislaine, additional, Kirby, Miles A., additional, Díaz-Artiga, Anaité, additional, McCracken, John, additional, Clark, Maggie L., additional, Waller, Lance, additional, Chang, Howard, additional, Wang, Jiantong, additional, Dusabimana, Ephrem, additional, Ndagijimana, Florien, additional, Sambandam, Sankar, additional, Mukhopadhyay, Krishnendu, additional, Kearns, Katherine, additional, Campbell, Devan, additional, Kremer, Jacob, additional, Rosenthal, Joshua, additional, Checkley, William, additional, Clasen, Thomas, additional, and Naeher, Luke, additional

Published
2021
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13. Compensating control participants when the intervention is of significant value: Experience in Guatemala, India, Peru and Rwanda

Author

Quinn, Ashlinn K, Williams, Kendra, Thompson, Lisa M, Rosa, Ghislaine, Diaz-Artiga, Anaite, Thangavel, Gurusamy, Balakrishnan, Kalpana, Miranda, J Jaime, Rosenthal, Joshua P, Clasen, Thomas F, Harvey, Steven A, Aravindalochanan, Vigneswari, Barr, Dana Boyd, Burrowes, Vanessa, Campbell, Devan, Campbell, Julia McPeek, Canuz, Eduardo, Castanaza, Adly, Chang, Howard, Checkley, William, Chen, Yunyun, Chiang, Marilu, Clark, Maggie L, Craik, Rachel, Crocker, Mary, Davila-Roman, Victor, de la Fuentes, Lisa, De Leon, Oscar, Dusabimana, Ephrem, Elon, Lisa, Gabriel Espinoza, Juan, Pineda Fuentes, Irma Sayury, Garg, Sarada, Goodman, Dina, Gupton, Savannah, Hardison, Megan, Hartinger, Stella, Herrera, Phabiola, Hossen, Shakir, Jaacks, Lindsay, Jabbarzadeh, Shirin, Johnson, Michael A, Jones, Abigail, Kearns, Katherine, Kirby, Miles, Kremer, Jacob, Laws, Margaret, Liao, Jiawen, Lovvorn, Amy, Majorin, Fiona, McCollum, Eric, McCracken, John, Meyers, Rachel, Mollinedo, Erick, Moulton, Lawrence, Mukhopadhyay, Krishnendu, Naeher, Luke, Nambajimana, Abidan, Ndagijimana, Florien, Nizam, Azhar, Ntivuguruzwa, Jean de Dieu, Papageorghiou, Aris, Peel, Jennifer, Piedrahita, Ricardo, Pillarisetti, Ajay, Puttaswamy, Naveen, Puzzolo, Elisa, Rajkumar, Sarah, Ramakrishnan, Usha, Reardon, David, Ryan, P Barry, Sakas, Zoe, Sambandam, Sankar, Sarnat, Jeremy, Simkovich, Suzanne, Sinharoy, Sheela, Smith, Kirk R, Steenland, Kyle, Swearing, Damien, Toenjes, Ashley, Underhill, Lindsay, Uwizeyimana, Jean Damascene, Valdes, Viviane, Verma, Amit, Waller, Lance, Warnock, Megan, Young, Bonnie, Investigators, HAPIN, Investigators, HAPIN, and Papageorghiou, A

Subjects
purl.org/pe-repo/ocde/ford#3.03.05 [https], Cash and cash equivalents, Control (management), 010501 environmental sciences, 01 natural sciences, Liquefied petroleum gas, Household economics, law.invention, compensation, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, purl.org/pe-repo/ocde/ford#3.03.02 [https], law, 030212 general & internal medicine, Socioeconomics, 0105 earth and related environmental sciences, 2. Zero hunger, Practice, Health Policy, Public Health, Environmental and Occupational Health, multi-country trial, ethics, Local community, Intervention (law), Stove, Business, randomised controlled trial
Abstract

The Household Air Pollution Intervention Network (HAPIN) trial is a randomised controlled trial in Guatemala, India, Peru and Rwanda to assess the health impact of a clean cooking intervention in households using solid biomass for cooking. The HAPIN intervention—a liquefied petroleum gas (LPG) stove and 18-month supply of LPG—has significant value in these communities, irrespective of potential health benefits. For control households, it was necessary to develop a compensation strategy that would be comparable across four settings and would address concerns about differential loss to follow-up, fairness and potential effects on household economics. Each site developed slightly different, contextually appropriate compensation packages by combining a set of uniform principles with local community input. In Guatemala, control compensation consists of coupons equivalent to the LPG stove’s value that can be redeemed for the participant’s choice of household items, which could include an LPG stove. In Peru, control households receive several small items during the trial, plus the intervention stove and 1 month of fuel at the trial’s conclusion. Rwandan participants are given small items during the trial and a choice of a solar kit, LPG stove and four fuel refills, or cash equivalent at the end. India is the only setting in which control participants receive the intervention (LPG stove and 18 months of fuel) at the trial’s end while also being compensated for their time during the trial, in accordance with local ethics committee requirements. The approaches presented here could inform compensation strategy development in future multi-country trials.

Published
2020

14. Developing Visual Messages to Support Liquefied Petroleum Gas Use in Intervention Homes in the Household Air Pollution Intervention Network (HAPIN) Trial in Rural Guatemala

Author

Hengstermann, Mayarí, primary, Díaz-Artiga, Anaité, additional, Otzóy-Sucúc, Roberto, additional, Laura Maria Ruiz-Aguilar, Ana, additional, Thompson, Lisa M., additional, Aravindalochanan, Vigneswari, additional, Balakrishnan, Kalpana, additional, Barr, Dana Boyd, additional, Burrowes, Vanessa, additional, Campbell, Devan, additional, Campbell, Julia McPeek, additional, Canuz, Eduardo, additional, Castañaza, Adly, additional, Chang, Howard, additional, Checkley, William, additional, Chen, Yunyun, additional, Chiang, Marilú, additional, Clark, Maggie L., additional, Clasen, Thomas, additional, Craik, Rachel, additional, Crocker, Mary, additional, Davila-Roman, Victor, additional, de las Fuentes, Lisa, additional, De Léon, Oscar, additional, Diaz-Artiga, Anaité, additional, Dusabimana, Ephrem, additional, Elon, Lisa, additional, Espinoza, Juan Gabriel, additional, Fuentes, Irma Sayury Pineda, additional, Garg, Sarada, additional, Goodman, Dina, additional, Gupton, Savannah, additional, Hardison, Meghan, additional, Hartinger, Stella, additional, Harvey, Steven A., additional, Hengstermann, Mayari, additional, Herrera, Phabiola, additional, Hossen, Shakir, additional, Howards, Penelope, additional, Jaacks, Lindsay, additional, Jabbarzadeh, Shirin, additional, Johnson, Michael A., additional, Jones, Abigail, additional, Kearns, Katherine, additional, Kirby, Miles, additional, Kremer, Jacob, additional, Laws, Margaret, additional, Liao, Jiawen, additional, Lovvorn, Amy, additional, Majorin, Fiona, additional, McCollum, Eric, additional, McCracken, John, additional, Meyers, Rachel, additional, Miranda, J. Jaime, additional, Mollinedo, Erick, additional, Moulton, Lawrence, additional, Mukhopadhyay, Krishnendu, additional, Naeher, Luke, additional, Nambajimana, Abidan, additional, Ndagijimana, Florien, additional, Nizam, Azhar, additional, de Dieu Ntivuguruzwa, Jean, additional, Papageorghiou, Aris, additional, Peel, Jennifer, additional, Piedrahita, Ricardo, additional, Pillarisetti, Ajay, additional, Puttaswamy, Naveen, additional, Puzzolo, Elisa, additional, Quinn, Ashlinn, additional, Rajkumar, Sarah, additional, Ramakrishnan, Usha, additional, Reardon, Davis, additional, Rosa, Ghislaine, additional, Rosenthal, Joshua, additional, Ryan, P. Barry, additional, Sakas, Zoe, additional, Sambandam, Sankar, additional, Sarnat, Jeremy, additional, Simkovich, Suzanne, additional, Sinharoy, Sheela, additional, Smith, Kirk R., additional, Steenland, Kyle, additional, Swearing, Damien, additional, Thangavel, Gurusamy, additional, Toenjes, Ashley, additional, Underhill, Lindsay, additional, Uwizeyimana, Jean Damascene, additional, Valdes, Viviane, additional, Verma, Amit, additional, Waller, Lance, additional, Warnock, Megan, additional, Williams, Kendra, additional, Ye, Wenlu, additional, and Young, Bonnie, additional

Published
2021
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24. Post-birth exposure contrasts for children during the Household Air Pollution Intervention Network randomized controlled trial.

Author

Pillarisetti A, Ye W, Balakrishnan K, Rosa G, Díaz-Artiga A, Underhill LJ, Steenland K, Peel JL, Kirby MA, McCracken J, Waller L, Chang H, Wang J, Dusabimana E, Ndagijimana F, Sambandam S, Mukhopadhyay K, Kearns KA, Campbell D, Kremer J, Rosenthal J, Ghosh A, Clark M, Checkley W, Clasen T, Naeher L, Piedrahita R, and Johnson M

Abstract

Exposure to household air pollution is a leading cause of ill-health globally. The Household Air Pollution Intervention Network (HAPIN) randomized controlled trial evaluated the impact of a free liquefied petroleum gas stove and fuel intervention on birth outcomes and maternal and child health. As part of HAPIN, an extensive exposure assessment was conducted. Here, we report on PM 2.5 and CO exposures of young children (≤ 15 months old) reconstructed using a Bluetooth-beacon based time-activity monitoring system coupled with microenvironmental pollutant monitors. Median (IQR) exposures to PM 2.5 were 65.1 (33 - 128.2) µg/m 3 in the control group and 22.9 (17.2 - 35.3) µg/m3 in the intervention group; for CO, median (IQR) exposures were 1.1 (0.3 - 2.9) ppm and 0.2 (0 - 0.7) ppm for control and intervention group, respectively. Exposure reductions were stable over time and consistent with previous findings for the children's mothers. In the intervention group, 75% of children's reconstructed exposures were below the WHO interim target guideline value of 35 µg/m 3 , while 26% were below the standard in the control group. Our findings suggest that an LPG fuel and stove intervention can substantially reduce children's exposure to household air pollution.

Published
2023
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25. Exposure Contrasts of Pregnant Women during the Household Air Pollution Intervention Network Randomized Controlled Trial.

Author

Johnson M, Pillarisetti A, Piedrahita R, Balakrishnan K, Peel JL, Steenland K, Underhill LJ, Rosa G, Kirby MA, Díaz-Artiga A, McCracken J, Clark ML, Waller L, Chang HH, Wang J, Dusabimana E, Ndagijimana F, Sambandam S, Mukhopadhyay K, Kearns KA, Campbell D, Kremer J, Rosenthal JP, Checkley W, Clasen T, and Naeher L

Subjects
Carbon Monoxide, Female, Humans, Particulate Matter, Pregnancy, Pregnant People, Soot, Air Pollution, Petroleum
Abstract

Background: Exposure to PM 2.5 arising from solid fuel combustion is estimated to result in ∼ 2.3 million premature deaths and 91 million lost disability-adjusted life years annually. Interventions attempting to mitigate this burden have had limited success in reducing exposures to levels thought to provide substantive health benefits., Objectives: This paper reports exposure reductions achieved by a liquified petroleum gas (LPG) stove and fuel intervention for pregnant mothers in the Household Air Pollution Intervention Network (HAPIN) randomized controlled trial., Methods: The HAPIN trial included 3,195 households primarily using biomass for cooking in Guatemala, India, Peru, and Rwanda. Twenty-four-hour exposures to PM 2.5 , carbon monoxide (CO), and black carbon (BC) were measured for pregnant women once before randomization into control ( n = 1,605 ) and LPG ( n = 1,590 ) arms and twice thereafter (aligned with trimester). Changes in exposure were estimated by directly comparing exposures between intervention and control arms and by using linear mixed-effect models to estimate the impact of the intervention on exposure levels., Results: Median postrandomization exposures of particulate matter (PM) with aerodynamic diameter ≤ 2.5 μ m ( PM 2.5 ) in the intervention arm were lower by 66% at the first (71.5 vs. 24.1   μ g / m 3 ), and second follow-up visits (69.5 vs. 23.7   μ g / m 3 ) compared to controls. BC exposures were lower in the intervention arm by 72% (9.7 vs. 2.7   μ g / m 3 ) and 70% (9.6 vs. 2.8   μ g / m 3 ) at the first and second follow-up visits, respectively, and carbon monoxide exposure was 82% lower at both visits (1.1 vs. 0.2  ppm ) in comparison with controls. Exposure reductions were consistent over time and were similar across research locations., Discussion: Postintervention PM 2.5 exposures in the intervention arm were at the lower end of what has been reported for LPG and other clean fuel interventions, with 69% of PM 2.5 samples falling below the World Health Organization Annual Interim Target 1 of 35   μ g / m 3 . This study indicates that an LPG intervention can reduce PM 2.5 exposures to levels at or below WHO targets. https://doi.org/10.1289/EHP10295.

Published
2022
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