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Your search keyword '"Krawczak, M. (Michael)"' showing total 2 results
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2 results on '"Krawczak, M. (Michael)"'

1. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level

Author

Pattaro, C. (Cristian), Grandi, A. (Alessandro) de, Vitart, V. (Veronique), Hayward, C. (Caroline), Franke, A. (Andre), Aulchenko, Y.S. (Yurii), Johansson, A. (Åsa), Wild, S.H. (Sarah), Melville, S.A. (Scott), Isaacs, A.J. (Aaron), Polasek, O. (Ozren), Ellinghaus, D. (David), Kolcic, I. (Ivana), Nöthlings, U. (Ute), Zgaga, L. (Lina), Zemunik, T. (Tatijana), Gnewuch, C. (Carsten), Schreiber, S. (Stefan), Campbell, S. (Susan), Hastie, N. (Nick), Boban, M. (Mladen), Meitinger, T. (Thomas), Oostra, B.A. (Ben), Riegler, P. (Peter), Minelli, C. (Cosetta), Wright, A.F. (Alan), Campbell, H. (Harry), Duijn, C.M. (Cornelia) van, Gyllensten, U. (Ulf), Wilson, J.F. (James), Krawczak, M. (Michael), Rudan, I. (Igor), Pramstaller, P.P. (Peter Paul), Pattaro, C. (Cristian), Grandi, A. (Alessandro) de, Vitart, V. (Veronique), Hayward, C. (Caroline), Franke, A. (Andre), Aulchenko, Y.S. (Yurii), Johansson, A. (Åsa), Wild, S.H. (Sarah), Melville, S.A. (Scott), Isaacs, A.J. (Aaron), Polasek, O. (Ozren), Ellinghaus, D. (David), Kolcic, I. (Ivana), Nöthlings, U. (Ute), Zgaga, L. (Lina), Zemunik, T. (Tatijana), Gnewuch, C. (Carsten), Schreiber, S. (Stefan), Campbell, S. (Susan), Hastie, N. (Nick), Boban, M. (Mladen), Meitinger, T. (Thomas), Oostra, B.A. (Ben), Riegler, P. (Peter), Minelli, C. (Cosetta), Wright, A.F. (Alan), Campbell, H. (Harry), Duijn, C.M. (Cornelia) van, Gyllensten, U. (Ulf), Wilson, J.F. (James), Krawczak, M. (Michael), Rudan, I. (Igor), and Pramstaller, P.P. (Peter Paul)

Abstract

Background: Serum creatinine (SCR) is the most important biomarker for a quick and non-invasive assessment of kidney function in population-based surveys. A substantial proportion of the inter-individual variability in SCR level is explicable by genetic factors.Methods: We performed a meta-analysis of genome-wide association studies of SCR undertaken in five population isolates ('discovery cohorts'), all of which are part of the European Special Population Network (EUROSPAN) project. Genes showing the strongest evidence f

Published
2010
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2. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

Author

Estrada Gil, K. (Karol), Krawczak, M. (Michael), Schreiber, S. (Stefan), Duijn, K. (Kate) van, Stolk, L. (Lisette), Meurs, J.B.J. (Joyce) van, Liu, F. (Fan), Penninx, B.W.J.H. (Brenda), Smit, J.H. (Jan), Vogelzangs, N. (Nicole), Hottenga, J.J. (Jouke Jan), Willemsen, G.A.H.M. (Gonneke), Geus, E.J.C. (Eco) de, Lorentzon, M. (Mattias), Eller-Eberstein, H. (Huberta) von, Lips, P. (Paul), Schoor, N. (Natascha), Pop, V.J.M. (Victor), Keijzer, J. (Jules) de, Hofman, A. (Albert), Aulchenko, Y.S. (Yurii), Oostra, B.A. (Ben), Ohlsson, C. (Claes), Boomsma, D.I. (Dorret), Uitterlinden, A.G. (André), Rivadeneira Ramirez, F. (Fernando), Kayser, M.H. (Manfred), Estrada Gil, K. (Karol), Krawczak, M. (Michael), Schreiber, S. (Stefan), Duijn, K. (Kate) van, Stolk, L. (Lisette), Meurs, J.B.J. (Joyce) van, Liu, F. (Fan), Penninx, B.W.J.H. (Brenda), Smit, J.H. (Jan), Vogelzangs, N. (Nicole), Hottenga, J.J. (Jouke Jan), Willemsen, G.A.H.M. (Gonneke), Geus, E.J.C. (Eco) de, Lorentzon, M. (Mattias), Eller-Eberstein, H. (Huberta) von, Lips, P. (Paul), Schoor, N. (Natascha), Pop, V.J.M. (Victor), Keijzer, J. (Jules) de, Hofman, A. (Albert), Aulchenko, Y.S. (Yurii), Oostra, B.A. (Ben), Ohlsson, C. (Claes), Boomsma, D.I. (Dorret), Uitterlinden, A.G. (André), Rivadeneira Ramirez, F. (Fernando), and Kayser, M.H. (Manfred)

Abstract

Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (Pcombined= 3.4 × 10-9). Notably, a second SNP (rs6718438) located ∼450 bp away and in strong LD (r2= 0.77) with rs6717918 was previously found to be suggestive of a height association in 29 820 individuals of mainly northwestern European ancestry, and the over-expression of a nearby natriuretic peptide precursor type C (NPPC) gene, has been associated with overgrowth and skeletal anomalies. We also found a SNP (rs10472828) located on 5p14 near the natriuretic peptide receptor 3 (NPR3) gene, encoding a receptor of the NPPC ligand, to be associated with body height (Pcombined= 2.1 × 10-7). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height.

Published
2009
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