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278 results on '"Krauss-Etschmann S"'

1. Serum Levels of Autoantibodies Against Extracellular Antigens and Neutrophil Granule Proteins Increase in Patients with COPD Compared to Non-COPD Smokers

Author

Ma A, Wen L, Yin J, Hu Y, Yue X, Li J, Dong X, Gupta Y, Ludwig RJ, Krauss-Etschmann S, Riemekasten G, Petersen F, and Yu X

Subjects
chronic obstructive pulmonary disease, autoimmunity, autoantibody profile, neutrophil granule proteins, lactorferrin., Diseases of the respiratory system, RC705-779
Abstract

Aiping Ma,1,* Lifang Wen,2,* Junping Yin,3 Yi Hu,4 Xiaoyang Yue,3 Jiurong Li,1 Xiaoru Dong,2 Yask Gupta,5 Ralf J Ludwig,5 Susanne Krauss-Etschmann,3,6 Gabriela Riemekasten,7 Frank Petersen,3 Xinhua Yu2,3 1Department of Respiratory Medicine, The First Affiliated Hospital, School of Medicine, Xiamen University, Xiamen, People’s Republic of China; 2Xiamen-Borstel Joint Laboratory of Autoimmunity, The Medical College of Xiamen University; 3Priority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany; 4Department of Clinical Laboratory, The First Affiliated Hospital, School of Medicine, Xiamen University, Xiamen, People’s Republic of China; 5Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany; 6Institute for Experimental Medicine, Christian-Albrechts-Universitaetzu Kiel, Kiel, Germany; 7Department of Rheumatology, University of Lübeck, Lübeck 23538, Germany*These authors contributed equally to this workCorrespondence: Xinhua YuPriority Area Asthma and Allergy, Research Center Borstel, Borstel 23845, GermanyTel +49 453 7188 2520Email xinhuayu@fz-borstel.deBackground: Chronic obstructive pulmonary disease (COPD) is a highly prevalent disease leading to irreversible airflow limitation and is characterized by chronic pulmonary inflammation, obstructive bronchiolitis and emphysema. Etiologically, COPD is mediated by toxic gases and particles, eg, cigarette smoke, while the pathogenesis of the disease is largely unknown. Several lines of evidence indicate a link between COPD and autoimmunity but comprehensive studies are lacking.Methods: By using a protein microarray assaying more than 19,000 human proteins we determined in this study the autoantibody profiles of COPD and non-COPD smokers. The discovery cohort included 5 COPD patients under acute exacerbation (AECOPD) and 5 age- and gender-matched non-COPD smokers. One putative candidate autoantibody, anti-lactoferrin IgG, was further investigated by using immunoblotting with a large validation cohort containing 124 healthy controls, 92 patients with AECOPD and 52 patients with stable COPD.Results: We show that i) autoantigens targeted by autoantibodies with higher titers in COPD patients were enriched in extracellular regions, while those with lower titers in COPD patients were enriched in intracellular compartments. ii) levels of IgG autoantibodies against many neutrophil granule proteins were significantly higher in COPD patients than in non-COPD smokers. Furthermore, increased levels of anti-lactoferrin antibodies in COPD patients were confirmed in a cohort with a large number of samples.Conclusion: The comprehensive autoantibody profiles from COPD patients established in this study demonstrated for the first time a shift in the cellular localization of antigens targeted by autoantibodies in COPD.Keywords: chronic obstructive pulmonary disease, autoimmunity, autoantibody profile, neutrophil granule proteins, lactoferrin

Published
2020

3. Antiviral CD8+ T cell immune responses are impaired by cigarette smoke and in COPD

Author

Wang, Y, primary, Chen, J., additional, Wang, X., additional, Schmalen, A., additional, Haines, S., additional, Wolff, M., additional, Stoleriu, M. G., additional, Nowak, J., additional, Nakayama, M., additional, Krauss-Etschmann, S., additional, Dmitrieva, A., additional, Frankenberger, M., additional, Hofer, T. P., additional, Noessner, E., additional, Moosmann, A., additional, Behr, J., additional, Milger, K., additional, Deeg, C. A., additional, Hauck, S. M., additional, Adler, H., additional, Kammerl, I. E., additional, and Meiners, S., additional

Published
2023
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7. Operational definition of Active and Healthy Ageing (AHA): A conceptual framework

Author

Bousquet, Jean, Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Mañas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Andersen Ranberg, K., Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Augé, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougère, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeande, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O’Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.

Published
2015
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9. Early priming of asthma and respiratory allergies: Future aspects of prevention: A statement by the European Forum for Education and Research in Allergy and Airway Disease (EUFOREA) and the EAACI-Clemens von Pirquet Foundation

Author

Wahn U, Lau S, Eigenmann P, Melen E, Krauss-Etschmann S, Lex C, Matricardi P, Schaub B, Halken S, Ege M, Jackson D, Hamelmann E, Szépfalusi Z, Garcia AN, and von Mutius E

Subjects
risk factors for allergy, prediction of asthma, asthma prevention, Allergy prevention
Abstract

In order to summarize recent research on the prevention of allergies-particularly asthma-and stimulate new activities for future initiatives, a virtual workshop sponsored by the EAACI Clemens von Pirquet foundation and EUFOREA was held in October 2021. The determinants of the "allergic march" as well as the key messages from intervention studies were reviewed by an international faculty of experts. Several unmet needs were identified, and a number of priorities for future studies were proposed.

Published
2022

10. Developmental determinants in non-communicable chronic diseases and ageing

Author

Bousquet, J, Anto, J M, Berkouk, K, Gergen, P, Antunes, J Pinto, Augé, P, Camuzat, T, Bringer, J, Mercier, J, Best, N, Bourret, R, Akdis, M, Arshad, S H, Bedbrook, A, Berr, C, Bush, A, Cavalli, G, Charles, M A, Clavel-Chapelon, F, Gillman, M, Gold, D R, Goldberg, M, Holloway, J W, Iozzo, P, Jacquemin, S, Jeandel, C, Kauffmann, F, Keil, T, Koppelman, G H, Krauss-Etschmann, S, Kuh, D, Lehmann, S, Carlsen, K C Lodrup, Maier, D, Méchali, M, Melén, E, Moatti, J P, Momas, I, Nérin, P, Postma, D S, Ritchie, K, Robine, J M, Samolinski, B, Siroux, V, Slagboom, P E, Smit, H A, Sunyer, J, Valenta, R, Van de Perre, P, Verdier, J M, Vrijheid, M, Wickman, M, Yiallouros, P, and Zins, M

Published
2015
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11. The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

Author

Lopez-Cervantes, JP, Lonnebotn, M, Jogi, NO, Calciano, L, Kuiper, IN, Darby, MG, Dharmage, SC, Gomez-Real, F, Hammer, B, Bertelsen, RJ, Johannessen, A, Wuertz, AML, Knudsen, TM, Koplin, J, Pape, K, Skulstad, SM, Timm, S, Tjalvin, G, Krauss-Etschmann, S, Accordini, S, Schluenssen, V, Kirkeleit, J, Svanes, C, Lopez-Cervantes, JP, Lonnebotn, M, Jogi, NO, Calciano, L, Kuiper, IN, Darby, MG, Dharmage, SC, Gomez-Real, F, Hammer, B, Bertelsen, RJ, Johannessen, A, Wuertz, AML, Knudsen, TM, Koplin, J, Pape, K, Skulstad, SM, Timm, S, Tjalvin, G, Krauss-Etschmann, S, Accordini, S, Schluenssen, V, Kirkeleit, J, and Svanes, C

Abstract

Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept.

Published
2021

14. Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease.

Author

Gosens, R, Hiemstra, PS, Adcock, IM, Bracke, KR, Dickson, RP, Hansbro, PM, Krauss-Etschmann, S, Smits, HH, Stassen, FRM, Bartel, S, Gosens, R, Hiemstra, PS, Adcock, IM, Bracke, KR, Dickson, RP, Hansbro, PM, Krauss-Etschmann, S, Smits, HH, Stassen, FRM, and Bartel, S

Abstract

Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community.

Published
2020

22. Distinct 'asthma' phenotypes of four mouse strains correlate with different responses to house dust mite (HDM) allergens

Author

Lund, J., Bartel, S., Orinska, Z., Lunding, L., Kull, S., Baines, J., Jappe, U., and Krauss-Etschmann, S.

Subjects
respiratory tract diseases
Abstract

Background: Asthma is a heterogeneous disease comprising different phenotypes. The corresponding “endotypes” are currently insufficiently understood thus hampering the development of personalized treatments. As a first step in this direction, models for experimental asthma reflecting different asthma phenotypes and endotypes need to be developed. Thus, we aimed to develop a murine model for the investigation of different responses to single Der p allergens. Method: Female mice of four different strains were obtained from Jackson Laboratory. Experimental asthma was induced by intranasal administration of 20 μg HDM extract (D. pteronyssinus extract, Greer, USA) three times weekly/ three weeks. Asthma phenotypes were evaluated by lung function measurements, histology, gene expression, immune cell infiltration, cytokine levels in broncho‐alveolar lavage (BAL) and total and allergen specific IgE in sera. Results: Higher airway resistance, elevated levels of BAL cell and eosinophil numbers, increased levels of IgE in sera and goblet cell hyperplasia were observed in all HDM treated animals in contrast to PBS‐treated controls. Initial tests measuring single anti‐Der p‐IgE reactivities (Der p 1, Der p 2, Der p 7, Der p 20, Der p 21, Der p 23) revealed distinct sensitization patterns for the different strains. The gene expression levels of MUC5B (fold‐change to control A/J: 7.5; BALB/cJ: 3.5; C57Bl/6J: 4.1; C3H/HeJ: 8.5) and CCL11(foldchange to control A/J: 72.7; BALB/cJ: 8.1; C57Bl/6J: 21.1; C3H/HeJ: 21.1) showed differences among the four strains. Combining all these results allowed us to characterize distinct “asthma” phenotypes, ranging from low eosinophilic, Th2 low (“low susceptible”) over an “intermediate susceptible” Th17 high to a mainly eosinophilic, Th2‐dominated phenotype with pronounced changes in lung histology (“high susceptible”). Conclusion: Applying the same HDM treatment in four different mouse strains resulted in distinct asthma phenotypes and showed for the very first time different sensitization patterns. In future studies, we will investigate the mechanisms underlying these different responses to different single Der p allergens and if possible investigate these in human asthma patients as well.

Published
2018

25. microRNA cluster 106a~363 is involved in T-Helper 17 (Th17) cell differentiation

Author

Kaestle, M., Bartel, S., Geillinger-Kästle, K., Irmler, M., Beckers, J., Ryffel, B., Eickelberg, O., and Krauss-Etschmann, S.

Subjects
Ror α, Nfat5, Rorγt, T Helper Cell Differentiation, Th17, Mir-106a, Mir-18b, Mir-363a-3p, Microrna
Abstract

T-helper cell 17 (Th17) mediated inflammation is associated with various diseases including autoimmune encephalitis, inflammatory bowel disease and lung diseases such as chronic obstructive pulmonary disease and asthma. Differentiation into distinct Th subtypes needs to be tightly regulated to ensure an immunological balance. As microRNAs (miRNAs) are critical regulators of signaling pathways, we aimed to identify specific miRNAs implicated in controlling Th17 differentiation. We were able to create a regulatory network model of murine Th cell differentiation by combining Affymetrix mRNA and miRNA arrays and in-silico analysis. In this model, the miR-212~132 and miR-182~183 clusters were significantly up-regulated upon Th17 differentiation, while the entire miR-106~363 cluster was down regulated and predicted to target well-known Th17 cell differentiation pathways. In-vitro transfection of miR-18b, miR-106 and miR-363 into primary murine CD4(+) lymphocytes decreased expression of retinoid-related orphan receptor c (Rorc), Rora, Il17a and Il17f, and abolished secretion of Th17 mediated Il17-a. Moreover, we demonstrated target site-specific regulation of the Th17 transcription factors Rora and nuclear factor of activated T-cells (Nfat) 5 by miR-18b, miR-106a and miR-363-3p through luciferase reporter assays. Here, we provide evidence that miRNAs are involved in controlling the differentiation and function of T-helper cells, offering useful tools to study and modify Th17 mediated inflammation.

Published
2017

26. Father's environment before conception and asthma risk in his children: A multi-generation analysis of the respiratory health In Northern Europe study

Author

Svanes, C., Koplin, J., Skulstad, S.M., Johannessen, A., Bertelsen, R.J., Benediktsdottir, B., Bråbäck, L., Elie Carsin, A., Dharmage, S., Dratva, J., Forsberg, B., Gislason, T., Heinrich, J., Holm, M., Janson, C., Jarvis, D., Jõgi, R., Krauss-Etschmann, S., Lindberg, E., Macsali, F., Malinovschi, A., Modig, L., Norbäck, D., Omenaas, E., Waatevik Saure, E., Sigsgaard, T., Skorge, T.D., Svanes, O., Torén, K., Torres, C., Schlünssen, V., and Gómez Real, F.

Subjects
Asthma, Epidemiology, Epigenesis, Occupational Exposure, Smoking
Abstract

BACKGROUND: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests that paternal environment before conception also impacts child health. We aimed to investigate the association between children's asthma risk and parental smoking and welding exposures prior to conception. METHODS: In a longitudinal, multi-country study, parents of 24 168 offspring aged 2-51 years provided information on their life-course smoking habits, occupational exposure to welding and metal fumes, and offspring's asthma before/after age 10 years and hay fever. Logistic regressions investigated the relevant associations controlled for age, study centre, parental characteristics (age, asthma, education) and clustering by family. RESULTS: Non-allergic early-onset asthma (asthma without hay fever, present in 5.8%) was more common in the offspring with fathers who smoked before conception {odds ratio [OR] = 1.68 [95% confidence interval (CI) = 1.18-2.41]}, whereas mothers' smoking before conception did not predict offspring asthma. The risk was highest if father started smoking before age 15 years [3.24 (1.67-6.27)], even if he stopped more than 5 years before conception [2.68 (1.17-6.13)]. Fathers' pre-conception welding was independently associated with non-allergic asthma in his offspring [1.80 (1.29-2.50)]. There was no effect if the father started welding or smoking after birth. The associations were consistent across countries. CONCLUSIONS: Environmental exposures in young men appear to influence the respiratory health of their offspring born many years later. Influences during susceptible stages of spermatocyte development might be important and needs further investigation in humans. We hypothesize that protecting young men from harmful exposures may lead to improved respiratory health in future generations.

Published
2017

27. Cigarette smoking and microbiome composition; lessons from both epidemiology and experimental models

Author

Gaede K, Kovacevic D, Pfeiffer S, Schloter M, Krauss-Etschmann S, and Herzmann C

Subjects
Global and Planetary Change, medicine.medical_specialty, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Pollution, Cigarette smoking, Environmental health, medicine, Microbiome, business, Composition (language)
Published
2019

28. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma

Author

Bartel, S., Schulz, N., Alessandrini, F., Schamberger, A., Pagel, P., Theis, F., Milger, K., Noessner, E., Stick, S., Kicic, Anthony, Eickelberg, O., Freishtat, R., Krauss-Etschmann, S., Bartel, S., Schulz, N., Alessandrini, F., Schamberger, A., Pagel, P., Theis, F., Milger, K., Noessner, E., Stick, S., Kicic, Anthony, Eickelberg, O., Freishtat, R., and Krauss-Etschmann, S.

Abstract

Asthma is highly prevalent, but current therapies cannot influence the chronic course of the disease. It is thus important to understand underlying early molecular events. In this study, we aimed to use microRNAs (miRNAs)-which are critical regulators of signaling cascades-to identify so far uncharacterized asthma pathogenesis pathways. Therefore, deregulation of miRNAs was assessed in whole lungs from mice with ovalbumin (OVA)-induced allergic airway inflammation (AAI). In silico predicted target genes were confirmed in reporter assays and in house-dust-mite (HDM) induced AAI and primary human bronchial epithelial cells (NHBE) cultured at the air-liquid interface. We identified and validated the transcription factor cAMP-responsive element binding protein (Creb1) and its transcriptional co-Activators (Crtc1-3) as targets of miR-17, miR-144, and miR-21. Sec14-like 3 (Sec14l3)-a putative target of Creb1-was down-regulated in both asthma models and in NHBE cells upon IL13 treatment, while it's expression correlated with ciliated cell development and decreased along with increasing goblet cell metaplasia. Finally, we propose that Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli. This study shows that miRNA profiles can be used to identify novel targets that would be overlooked in mRNA based strategies.

Published
2017

29. Relationship between genome and epigenome - challenges and requirements for future research

Author

Almouzni, G., Altucci, L., Amati, B., Ashley, N., Baulcombe, D., Beaujean, N., Bock, C., Bongcam-Rudloff, E., Bousquet, J., Braun, S., Bressac-de Paillerets, B., Bussemakers, M., Clarke, L., Conesa, A., Estivill, X., Fazeli, A., Grgurevic, N., Gut, I., Heijmans, B.T., Hermouet, S., Houwing-Duistermaat, J., Iacobucci, I., Ilas, J., Kandimalla, R., Krauss-Etschmann, S., Lasko, P., Lehmann, S., Lindroth, A., Majdic, G., Marcotte, E., Martinelli, G., Martinet, N., Meyer, E., Miceli, C., Mills, K., Moreno-Villanueva, M., Morvan, G., Nickel, D., Niesler, B., Nowacki, M., Nowak, J., Ossowski, S., Pelizzola, M., Pochet, R., Potocnik, U., Radwanska, M., Raes, J., Rattray, M., Robinson, M.D., Roelen, B., Sauer, S., Schinzer, D., Slagboom, E., Spector, T., Stunnenberg, H.G., Tiligada, E., Torres-Padilla, M.E., Tsonaka, R., Soom, A. van, Vidakovic, M., Widschwendter, M., Dynamique du noyau, Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Dip. Patologia generale, Seconda Università di Napoli, Università degli studi di Napoli Federico II, University of Cambridge [UK] (CAM), Biologie du Développement et Reproduction (BDR), Institut National de la Recherche Agronomique (INRA), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria, Swedish University of Agricultural Sciences (SLU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centro de Genomica, Instituto Valenciano de Investigaciones Agrarias, Universitat Pompeu Fabra [Barcelona], Institute of Biomedicine and Translational Medicine, Department of Pathophysiology, University of Tartu, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Molecular Mechanisms of Chronic Inflammation in Hematological Diseases ( CRCINA - Département INCIT - Equipe 16), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Comprehensive Pneumology Center, Ludwig Maximilians University and Helmholtz Zentrum Muenchen, Member of the German Research Center for Lung Research, Großhadern, Germany, McGill University, GeoBiosphere Science Centre, Lund University [Lund], Biologie Cellulaire et Moleculaire du Transport des Nutriments, Université Henri Poincaré - Nancy 1 (UHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Langues et Civilisations Orientales (Inalco), School of biosciences and biotechnology, Università di Camerino (UNICAM), Haematology Research Group, Queen's University [Belfast] (QUB)-CCRCB, University of Konstanz, Institute of Cell Biology, University of Bern, University of Bern, Laboratoire de Parasitologie, Université Libre de Bruxelles [Bruxelles] (ULB), Vrije Universiteit [Brussels] (VUB), Faculty of Life Sciences [Manchester], University of Manchester [Manchester], Max Planck Institute for Molecular Genetics (MPIMG), Max-Planck-Gesellschaft, Section Molecular Epidemiology, Leiden University Medical Center (LUMC), Centre for Molecular Life Sciences (NCMLS), Department of Molecular Biology, Radboud university [Nijmegen], Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique (CNRS), Department of Gynaecological Oncology, Institute for Women's Health, University College of London [London] (UCL), Dynamique du noyau [Institut Curie], Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Biologie du développement et reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Centro de Genómica - Centre de Genòmica [IVIA], Instituto Valenciano de Investigaciones Agrarias - Institut Valencià d'Investigacions Agraries - Valencian Institute for agricultural Research (IVIA), Universitat Pompeu Fabra [Barcelona] (UPF), Molecular Mechanisms of Chronic Inflammation in Hematological Diseases (CRCINA-ÉQUIPE 16), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), McGill University = Université McGill [Montréal, Canada], Università degli Studi di Camerino (UNICAM), Université libre de Bruxelles (ULB), Vrije Universiteit Brussel (VUB), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), LS Voortplanting Inwendige Ziekten, Sub Celbiologisch lab., Biology of Reproductive Cells, ES/FAH BRC, Almouzni, G, Altucci, Lucia, Amati, B, Ashley, N, Baulcombe, D, Beaujean, N, Bock, C, Bongcam Rudloff, E, Bousquet, J, Braun, S, Paillerets, Bb, Bussemakers, M, Clarke, L, Conesa, A, Estivill, X, Fazeli, A, Grgurević, N, Gut, I, Heijmans, Bt, Hermouet, S, Houwing Duistermaat, J, Iacobucci, I, Ilaš, J, Kandimalla, R, Krauss Etschmann, S, Lasko, P, Lehmann, S, Lindroth, A, Majdič, G, Marcotte, E, Martinelli, G, Martinet, N, Meyer, E, Miceli, C, Mills, K, Moreno Villanueva, M, Morvan, G, Nickel, D, Niesler, B, Nowacki, M, Nowak, J, Ossowski, S, Pelizzola, M, Pochet, R, Potočnik, U, Radwanska, M, Raes, J, Rattray, M, Robinson, Md, Roelen, B, Sauer, S, Schinzer, D, Slagboom, E, Spector, T, Stunnenberg, Hg, Tiligada, E, Torres Padilla, Me, Tsonaka, R, Soom, Av, Vidaković, M, Widschwendter, M., University of Naples Federico II = Università degli studi di Napoli Federico II, École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Università degli Studi di Camerino = University of Camerino (UNICAM), Universität Bern [Bern] (UNIBE), Radboud University [Nijmegen], and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Epigenomics, [SDV]Life Sciences [q-bio], MESH: Epigenomics, programme de recherche scientifique, Epigenesis, Genetic, Epigenome, Biologie de la reproduction, MESH: Epigenesis, Genetic, epidrugs, génération, DNA METHYLATION, ComputingMilieux_MISCELLANEOUS, Reproductive Biology, évolution de la maladie, Genome, MESH: Genomics, Biologie du développement, DEATH, Genomics, Development Biology, CANCER, MESH: Research, impact environnemental, Technology Platforms, genome, epigenome, microbiome, environment, STEM-CELLS, epigenetic, Biotechnology, durée de vie, programme européen, facteur génétique, INHIBITION, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Environment, maladie, ddc:570, Correspondence, Genetics, Humans, cancer, MESH: Genome, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Veterinary Sciences, Microbiome, MESH: Humans, Research, santé publique, 570 Life sciences, biology, sensibilité aux maladies, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Understanding the links between genetic, epigenetic and non-genetic factors throughout the lifespan and across generations and their role in disease susceptibility and disease progression offer entirely new avenues and solutions to major problems in our society. To overcome the numerous challenges, we have come up with nine major conclusions to set the vision for future policies and research agendas at the European level. ispartof: BMC Genomics vol:15 issue:1 pages:487-487 ispartof: location:England status: published

Published
2014

30. Impairment of immunoproteasome function by cigarette smoke and in COPD

Author

Kammerl, I.E., Dann, A., Mossina, A., Brech, D., Lukas, C., Vosyka, O., Nathan, P., Conlon, T.M., Wagner, D.E., Overkleeft, H.S., Prasse, A., Rosas, I.O., Straub, T., Krauss-Etschmann, S., Königshoff, M., Preissler, G., Winter, H., Lindner, M., Hatz, R.A., Behr, J., Heinzelmann, K., Yildirim, A.Ö., Nößner, E., Eickelberg, O., and Meiners, S.

Subjects
Mhc Class I Antigen Presentation, Alveolar Macrophages, Cigarette Smoke, Immunoproteasome, respiratory system, respiratory tract diseases
Abstract

RATIONALE: Chronic obstructive pulmonary disease patients and in particular smokers are more susceptible to respiratory infections contributing to acute exacerbations of disease. The immunoproteasome is a specialized type of proteasome destined to improve major histocompatibility complex (MHC) class I-mediated antigen presentation for the resolution of intracellular infections. OBJECTIVES: To characterize immunoproteasome function in COPD and its regulation by cigarette smoke. METHODS: Immunoproteasome expression and activity were determined in bronchoalveolar lavage (BAL) and lungs of human donors, COPD, and IPF patients, as well as in cigarette smoke-exposed mice. Smoke-mediated alteration of immunoproteasome activity and MHC I surface expression were analysed in human blood-derived macrophages. Immunoproteasome-specific MHC I antigen presentation was evaluated in spleen and lung immune cells that had been smoke-exposed in vitro or in vivo. MEASUREMENTS AND MAIN RESULTS: Immunoproteasome and MHC I mRNA expression was reduced in BAL cells of COPD patients and in isolated alveolar macrophages of COPD and IPF patients. Exposure of immune cells to cigarette smoke extract in vitro reduced immunoproteasome activity and impaired immunoproteasome-specific MHC I antigen presentation. In vivo, acute cigarette smoke exposure dynamically regulated immunoproteasome function and MHC I antigen presentation in mouse BAL cells. End-stage COPD lungs showed markedly impaired immunoproteasome activities. CONCLUSIONS: We here show for the first time that the activity of the immunoproteasome is impaired by cigarette smoke resulting in reduced MHC I antigen presentation. Regulation of immunoproteasome function by cigarette smoke may thus alter adaptive immune responses and add to prolonged infections and exacerbations in COPD and IPF.

Published
2016

42. Operational definition of Active and Healthy Ageing (AHA) : A conceptual framework

Author

Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., Zins, M., Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.

Published
2015

43. Developmental determinants in non-communicable chronic diseases and ageing

Author

Cardiometabolic Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J, Anto, J M, Berkouk, K, Gergen, P, Antunes, J Pinto, Augé, P, Camuzat, T, Bringer, J, Mercier, J, Best, N, Bourret, R, Akdis, M, Arshad, S H, Bedbrook, A, Berr, C, Bush, A, Cavalli, G, Charles, M A, Clavel-Chapelon, F, Gillman, M, Gold, D R, Goldberg, M, Holloway, J W, Iozzo, P, Jacquemin, S, Jeandel, C, Kauffmann, F, Keil, T, Koppelman, G H, Krauss-Etschmann, S, Kuh, D, Lehmann, S, Carlsen, K C Lodrup, Maier, D, Méchali, M, Melén, E, Moatti, J P, Momas, I, Nérin, P, Postma, D S, Ritchie, K, Robine, J M, Samolinski, B, Siroux, V, Slagboom, P E, Smit, H A, Sunyer, J, Valenta, R, Van de Perre, P, Verdier, J M, Vrijheid, M, Wickman, M, Yiallouros, P, Zins, M, Cardiometabolic Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J, Anto, J M, Berkouk, K, Gergen, P, Antunes, J Pinto, Augé, P, Camuzat, T, Bringer, J, Mercier, J, Best, N, Bourret, R, Akdis, M, Arshad, S H, Bedbrook, A, Berr, C, Bush, A, Cavalli, G, Charles, M A, Clavel-Chapelon, F, Gillman, M, Gold, D R, Goldberg, M, Holloway, J W, Iozzo, P, Jacquemin, S, Jeandel, C, Kauffmann, F, Keil, T, Koppelman, G H, Krauss-Etschmann, S, Kuh, D, Lehmann, S, Carlsen, K C Lodrup, Maier, D, Méchali, M, Melén, E, Moatti, J P, Momas, I, Nérin, P, Postma, D S, Ritchie, K, Robine, J M, Samolinski, B, Siroux, V, Slagboom, P E, Smit, H A, Sunyer, J, Valenta, R, Van de Perre, P, Verdier, J M, Vrijheid, M, Wickman, M, Yiallouros, P, and Zins, M

Published
2015

44. Operational definition of Active and Healthy Ageing (AHA): A conceptual framework

Author

Cardiometabolic Health, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., Zins, M., Cardiometabolic Health, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.

Published
2015

45. Exosomal microRNA-17 and-21 in murine experimental and human paediatric asthma

Author

Bartel, S., Schulz, N., Schamberger, A., Alessandrini, F., Noessner, E., Stick, S., Kicic, Anthony, Eickelberg, O., Freishtat, R., Krauss-Etschmann, S., Bartel, S., Schulz, N., Schamberger, A., Alessandrini, F., Noessner, E., Stick, S., Kicic, Anthony, Eickelberg, O., Freishtat, R., and Krauss-Etschmann, S.

Published
2015

47. Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease

Author

Krauss-Etschmann, S., Bush, A., Bellusci, S., Brusselle, G.G., Dahlén, S.E., Dehmel, S., Eickelberg, O., Gibson, G., Hylkema, M.N., Knaus, P., Königshoff, M., Lloyd, C.M., Macciarini, P., Mailleux, A., Marsland, B.J., Postma, D.S., Roberts, G., Samakovlis, C., Stocks, J., Vandesompele, J., Wjst, M., and Holloway, J.

Subjects
respiratory tract diseases
Abstract

Despite intensive research efforts, the aetiology of the majority of chronic lung diseases (CLD) in both, children and adults, remains elusive. Current therapeutic options are limited, providing only symptomatic relief, rather than treating the underlying condition, or preventing its development in the first place. Thus, there is a strong and unmet clinical need for the development of both, novel effective therapies and preventative strategies for CLD. Many studies suggest that modifications of prenatal and/or early postnatal lung development will have important implications for future lung function and risk of CLD throughout life. This view represents a fundamental change of current pathophysiological concepts and treatment paradigms, and holds the potential to develop novel preventative and/or therapeutic strategies. However, for the successful development of such approaches, key questions, such as a clear understanding of underlying mechanisms of impaired lung development, the identification and validation of relevant preclinical models to facilitate translational research, and the development of concepts for correction of aberrant development, all need to be solved. Accordingly, a European Science Foundation Exploratory Workshop was held where clinical, translational and basic research scientists from different disciplines met to discuss potential mechanisms of developmental origins of CLD, and to identify major knowledge gaps in order to delineate a roadmap for future integrative research.

Published
2013

48. Identification of a plasma mi RNA biomarker signature for allergic asthma: A translational approach.

Author

Milger, K., Götschke, J., Krause, L., Nathan, P., Alessandrini, F., Tufman, A., Fischer, R., Bartel, S., Theis, F. J., Behr, J., Dehmel, S., Mueller, N. S., Kneidinger, N., and Krauss‐Etschmann, S.

Subjects
ANIMAL disease models, ASTHMA, MICRORNA, PHENOTYPES, GENE expression
Abstract

Background Asthma is a heterogeneous chronic disease with different phenotypes and treatment responses. Thus, there is a high clinical need for molecular disease biomarkers to aid in differentiating these distinct phenotypes. As Micro RNAs (mi RNAs), that regulate gene expression at the post-transcriptional level, are altered in experimental and human asthma, circulating mi RNAs are attractive candidates for the identification of novel biomarkers. This study aimed to identify plasmatic mi RNA-based biomarkers of asthma, through a translational approach. Methods We prescreened mi RNAs in plasma samples from two different murine models of experimental asthma (ovalbumin and house dust mite); mi RNAs deregulated in both models were further tested in a human training cohort of 20 asthma patients and 9 healthy controls. Candidate mi RNAs were then validated in a second, independent group of 26 asthma patients and 12 healthy controls. Results Ten mi RNA ratios consisting of 13 mi RNAs were differentially regulated in both murine models. Measuring these mi RNAs in the training cohort identified a biomarker signature consisting of five mi RNA ratios (7 mi RNAs). This signature showed a good sensitivity and specificity in the test cohort with an area under the receiver operating characteristic curve ( AUC) of 0.92. Correlation of mi RNA ratios with clinical characteristics further revealed associations with FVC % predicted, and oral corticosteroid or antileukotriene use. Conclusion Distinct plasma mi RNAs are differentially regulated both in murine and in human allergic asthma and were associated with clinical characteristics of patients. Thus, we suggest that mi RNA levels in plasma might have future potential to subphenotype patients with asthma. [ABSTRACT FROM AUTHOR]

Published
2017
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50. Operative definition of active and healthy ageing (AHA): Meeting report. Montpellier October 20–21, 2014

Author

Bousquet, J., primary, Kuh, D., additional, Bewick, M., additional, Strandberg, T., additional, Farrell, J., additional, Pengelly, R., additional, Joel, M.E., additional, Rodriguez Mañas, L., additional, Mercier, J., additional, Bringer, J., additional, Camuzat, T., additional, Bourret, R., additional, Bedbrook, A., additional, Kowalski, M.L., additional, Samolinski, B., additional, Bonini, S., additional, Brayne, C., additional, Michel, J.P., additional, Venne, J., additional, Viriot-Durandal, P., additional, Alonso, J., additional, Avignon, A., additional, Bousquet, P.J., additional, Combe, B., additional, Cooper, R., additional, Hardy, R., additional, Iaccarino, G., additional, Keil, T., additional, Kesse-Guyot, E., additional, Momas, I., additional, Ritchie, K., additional, Robine, J.M., additional, Thijs, C., additional, Tischer, C., additional, Vellas, B., additional, Zaidi, A., additional, Alonso, F., additional, Andersen Ranberg, K., additional, Andreeva, V., additional, Ankri, J., additional, Arnavielhe, S., additional, Arshad, S.H., additional, Augé, P., additional, Berr, C., additional, Bertone, P., additional, Blain, H., additional, Blasimme, A., additional, Buijs, G.J., additional, Caimmi, D., additional, Carriazo, A., additional, Cesario, A., additional, Coletta, J., additional, Cosco, T., additional, Criton, M., additional, Cuisinier, F., additional, Demoly, P., additional, Fernandez-Nocelo, S., additional, Fougère, B., additional, Garcia-Aymerich, J., additional, Goldberg, M., additional, Guldemond, N., additional, Gutter, Z., additional, Harman, D., additional, Hendry, A., additional, Heve, D., additional, Illario, M., additional, Jeandel, C., additional, Krauss-Etschmann, S., additional, Krys, O., additional, Kula, D., additional, Laune, D., additional, Lehmann, S., additional, Maier, D., additional, Malva, J., additional, Matignon, P., additional, Melen, E., additional, Mercier, G., additional, Moda, G., additional, Nizinkska, A., additional, Nogues, M., additional, O’Neill, M., additional, Pelissier, J.Y., additional, Poethig, D., additional, Porta, D., additional, Postma, D., additional, Puisieux, F., additional, Richards, M., additional, Robalo-Cordeiro, C., additional, Romano, V., additional, Roubille, F., additional, Schulz, H., additional, Scott, A., additional, Senesse, P., additional, Slagter, S., additional, Smit, H.A., additional, Somekh, D., additional, Stafford, M., additional, Suanzes, J., additional, Todo-Bom, A., additional, Touchon, J., additional, Traver-Salcedo, V., additional, Van Beurden, M., additional, Varraso, R., additional, Vergara, I., additional, Villalba-Mora, E., additional, Wilson, N., additional, Wouters, E., additional, and Zins, M., additional

Published
2015
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