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1. Endovascular thrombectomy for acute ischaemic stroke with established large infarct (TENSION): 12-month outcomes of a multicentre, open-label, randomised trial

Author

Aamodt, Anne Hege, Adamczewski, Olaf, Alektoror, Kirill, Alexander, März, Alexandrou, Maria, Alias, Quentin, Al-Kuzae, Fadha Elawi, Allard, Julien, Al-Schameri, Rahman, Álvarez, Alberto, Andersen, Grethe, AnkerlundBlaufeldt, Rolf, Antje, Riedel, Appelbohm, Hannes, Argren, Maria, Assmann, Anne, Augustin, Michael, Bach, Elke, Bar, Michal, Barleben, Maria, Baronnet, Flore, Barrios, Andrés, Bavúzová, Xénia, BayThomsen, Rikke, Becker, Sandra, Beer, Sylvia, Behme, Daniel, Bellut, Maximilian, Bendszus, Martin, Berkefeld, Joachim, Bester, Maximillian, Bode, Felix J., Boehme, Christian, Boese, Ramona, Bohmann, Ferdinand, Bonekamp, Susanne, Borggrefe, Jan, Boss, Erendira Gabriela, Boutchakova, Maria, Boxhammer, Elfi, Brandhofe, Annemarie, Breckwoldt, Michael, Brekenfeld, Casper, Brehm, Alex, Brem, Christian, Breuer, Stella, Breyer, Tobias, Brodová, Petra, Broocks, Gabriel, Brosinski, Christoph, Bubel, Nele, Búřil, Jiří, Čábal, Martin, Casado, Laura, de Celis, Elena, Chabert, Emmanuel, Charisse, Daniel, Cheng, Bastian, Chovanec, Vendelín, Cidlinsky, Peter, Cisár, Juraj, Clarençon, Fréderic, Crozier, Sophie, Čurdová, Nina, Damaskinos, Michele, Damgaard, Dorte, Daniš, Martin, Dazinger, Florian, Deb-Chatterji, Milani, Delalic, Asima, Delekta, Agnieszka, Delorme, Stephen, Deutschmann, Hannes, Diamandis, Elie, Diedrichsen, Tove, Doležalová, Irena, Dorn, Franziska, du Mesnil de Rochemont, Richard, DupontHougaard, Kristina, Ebrahimi, Taraneh, Eff, Florian, Eliášová, Ilona, Enriquez, Brian, Ergawy, Mostafa, Essig, Fabian, Falkesgaard, Maiken, Fandler-Höfler, Simon, Fernández, Andrés, Ferré, Jean-Christophe, Ferrier, Anna, Fiehler, Jens, Figlewski, Krystian, Fischer, Sebastian, Fischer, Urs, Flottmann, Fabian, Forbrig, Robert, Förch, Christian, Fromm, Annette, Fuentes, Blanca, Gaedke, Ines, Galczak, Romana, Galijasevic, Malik, Ganser, Bernhard, Gattringer, Thomas, Gawlitza, Matthias, Gelhard, Sarah, Gellißen, Susanne, Gerber, Johannes, Giannakakis, Michail Panagiotis, Gindlhuber, Karin, Gizewski, Elke R., Glodny, Bernhard, Godel, Tim, Goebell, Einar, Goldemund, David, Görtler, Michael, Goyal, Mayank, Grams, Astrid E., Gruber, Joachim, Gruber, Katharina, Günthner-Lengsfeld, Thomas, Haase, Kathrin, Hacker-Ivan, Floriana, Hallerstig, Erika, Hametner, Christian, Hanning, Uta, Haring, Jozef, Haršány, Michal, Haršány, Ján, Hartmann, Christian, Hassler, Eva Maria, Hauptmann, Kristina, Haeusler, Karl Georg, Hecker, Constantin, Hellstern, Victoria, Henkes, Hans, Hernández, Victoria, Herweh, Christian, Hilgenfeld, Tim, Hill, Michael D., Hjort, Niels, HjortJensen, Nina, Hoelter, Maya, Hoffmann, Karl-Titus, Holst, Brigitte, Holtmannspoetter, Markus, Hopf-Jensen, Silke, Hoppe, Julia, Horner, Susanne, HougaardSoerensen, Leif, Hua, Vi Tuan, Hubert, Alexander, Hurtíková, Eva, Jakubíček, Stanislava, Janjic, Tanja, Jaramillo, Kirsten, Jedlitschka, Angela, Jensen, Schiela, Jensen, Märit, Jesser, Jessica, Jestaedt, Leonie, Johnson, Sabine, Jonszta, Tomáš, Kalmar, Peter, Karabegovic, Sanja, Karen, Kollo, Kastrup, Andreas, Katja, Hopp, Keeba, Natalia, Keese, Petra, Kefaloykos, Christina, Keil, Fee, Kellert, Lars, Kellinghaus, Christoph, Kestner, Roxane-Isabelle, Kiechl, Stefan, Killer-Oberpfalzer, Monika, Klepanec, Andrej, Knispel, Casjupea, Knoflach, Michael, Kohler, Sabine, Kohlhase, Konstantin, Kollikowski, Alexander Marco, Kovář, Martin, Krajina, Antonín, Kral, Michael, Krastev, Georgi, Krause, Lars Udo, Kreidenhuber, Rudolf, Křivka, Tomáš, Krkoška, Adam, Kröger, Jan Robert, Kronlage, Moritz, Krukowski, Pawel, Kühn, Julia, Kurča, Egon, Kurka, Natalia, Kuschnerow, Michael, Lachmund, Rita, Lamprecht, Susanne, Lange, Rüdiger, Lauer, Monika, de Leciñana, Alonso, Leder, Sara, Leger, Anne, Lehnen, Nils, Lehrieder, Dominik, Leißner, Maximilian, Leitinger, Markus, Leitner, Ursula, Lenck, Stéphanie, Lenzenweger, Eva, Liebig, Thomas, Lowens, Stephan, Lunzer, Manuel, Maegerlein, Christian, Magyar, Marton, Marques, Leonardo, Matyáš, David, Maurer, Gabriele, Mauritz, Matthias, Maximilian, Thormann, Mayer-Süß, Lukas, Meckel, Stephan, Medek, Oldřich, Meissner, Julius N., Mencl, Pavel, Merkle, Andrea, Mesche, Birte, Michalski, Dominik, Mikulík, Robert, Modrau, Boris, Möhlenbruch, Markus A., Mohr, Alexander, Mönninghoff, Christoph, Moser, Tobias, Mücke, Ramona, Müller-Hülsbeck, Stefan, Müller-Thies-Broussalis, Erasmia, Mutzenbach, Sebastian, Navia, Pedro, Neuberger, Ulf, Neugebauer, Hermann, Neumann, Jens, Nguyên, Anh, Niederkorn, Kurt, Nosál', Vladimír, Novobilský, Richard, Ntoulias, Nikos, Nussbaum, Lukas, Oder, Joanna, Oldag, Andreas, Ondrejkovič, Marián, Otto, Ferdinand, Otto, Dagmar, Paech, Daniel, Pagano, Paolo, Pallesen, Lars-Peder, Panský, Michal, Papanagiotou, Panagiotis, Patrick, Samp, Paukisch, Harald, Pelz, Johann, Petersen, Inga, Petersen, Martina, Petzold, Gabor C., Pfaff, Johannes, Pfeilschifter, Waltraud, Pham, Mirko, Pichler, Alexander, Pierot, Laurent, Pikija, Slaven, PlougmannPovlsen, Jan, Polkowski, Christoph, Polomac, Nenad, Portugaller, Rupert Horst, Poulsen, Marika, Preiß, Michael, Premat, Kévin, Prestsæter, Sjur, Prieto-Pérez, Rocio, Psychogios, Marios, Puetz, Volker, Purrucker, Jan, Rai, Heike, Rauch, Maximilian, Raupach, Jan, Reimann, Gernot, Reimann, Georg, Reitz, Sarah, Renc, Ondřej, Retzlaff, Jasmin, Rigual, Ricardo, Ringleb, Peter Arthur, Rivera-Bengoa, Carlota, Rodríguez, Jorge, Rohde, Stefan, Rohler, Siegfried, Rosso, Charlotte, Roth, Christian, Röttcher, Thomas, Roubec, Martin, Roztočilová, Milada, Rudnicka, Svetlana, Ruiz, Gerardo, Ryan, Stephen, Ryckborst, Karla J., Sandvik, Simen, Schäfer, Jan-Hendrik, Schaller-Paule, Martin, Schell, Maximillian, Schellinger, Peter, Schlemm, Eckhard, Schmid, Florian, Schmidt, Christoph, Schmitz, Marie Louise, Schneider, Claus, Scholtz, Jan-Erik, Schönenberger, Silvia, Schröter, Andreas, Schwarz, Daniel, Schwarz, Stephan, Schwarzenhofer, Daniel, Seifert-Held, Thomas, Seiler, Alexander, Seker, Fatih, Shotar, Eimad, Simonsen, Claus Z., Simonsen, Maria Theresa, Sivák, Jozef, Skagen, Karolina, Skjelland, Mona, Šnajdrová, Alena, Solymosi, Lazlo, Sømark, Jesper, Sonnberger, Michael, Soršák, Jakub, Sourour, Nader, Søyland, Jogrim, Spitzer, Daniel, Sporns, Peter, Städt, Michael, Steidl, Eike, Størdal, Anne Margrethe Kaalaas, Stösser, Sebastian, Strickmann, Sarah, Strýček, Ondřej, Suškevič, Igor, Sýkora, Jan, Tennøe, Bjørn, Thaler, Daniela, Theisen, Sara, Thomalla, Götz, Trendafilov, Petar, Trenkler, Johannes, Trumm, Christoph, Tsogkas, Ioannis, Tunold, Jon-Anders, Tveit, Lars, Ulfert, Christian, Vališ, Kateřina, Vaníček, Jiří, Vassilev, Christine, Vítková, Eva, Voit-Höhne, Heinz-Leonhard, Vojtíšek, Bohuslav, Volderauer, Karoline, Vollherbst, Dominik, Vollmuth, Christoph, Volna, Kamila, Volný, Ondřej, VonWeitzel-Mudersbach, Poul, Vorčák, Martin, Wagner, Marlies, Wathle, Gaute Kjellevold, Weber, Werner, Weber, Anushe, Weiss, Viktor, Weller, Johannes M., Wenger-Alakmeh, Katharina, Weyland, Cyrill, Weymayr, Friedrich, Wießpeiner, Ulrike, Willeit, Johannes, Wittwer, Aymeric, Wollenweber, Frank, Wortmann, Ginette, Wunderlich, Silke, Xiong, Yanyan, You, Se-Jong, ZachoSpeiser, Lasse, Zamani, Mahtab, Zelenak, Kamil, Zeleňáková, Jana, Zubel, Seraphine, Subtil, Fabien, Gizewski, Elke R, Hill, Michael D, Krajina, Antonin, Simonsen, Claus Z, Zeleňák, Kamil, Blauenfeldt, Rolf A, Denis, Angélique, Gerber, Johannes C, Keil, Christiane Fee, Mikkelsen, Ronni, Möhlenbruch, Markus, Münnich, Nico, Petzold, Gabor C, Schell, Maximilian, Vollherbst, Dominik F, and Wick, Wolfgang

Published
2024
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2. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial

Author

Aamodt, Anne Hege, Adamczewski, Olaf, Alektoror, Kirill, Alexander, März, Alexandrou, Maria, Alias, Quentin, Al-Kuzae, Fadha Elawi, Allard, Julien, Al-Schameri, Rahman, Álvarez, Alberto, Andersen, Grethe, AnkerlundBlaufeldt, Rolf, Antje, Riedel, Appelbohm, Hannes, Argren, Maria, Assmann, Anne, Augustin, Michael, Bach, Elke, Bar, Michal, Barleben, Maria, Baronnet, Flore, Barrios, Andrés, Bavúzová, Xénia, BayThomsen, Rikke, Becker, Sandra, Beer, Sylvia, Behme, Daniel, Bellut, Maximilian, Bendszus, Martin, Berkefeld, Joachim, Bester, Maximillian, Bode, Felix J., Boehme, Christian, Boese, Ramona, Bohmann, Ferdinand, Bonekamp, Susanne, Borggrefe, Jan, Boss, Erendira Gabriela, Boutchakova, Maria, Boxhammer, Elfi, Brandhofe, Annemarie, Breckwoldt, Michael, Brekenfeld, Casper, Brehm, Alex, Brem, Christian, Breuer, Stella, Breyer, Tobias, Brodová, Petra, Broocks, Gabriel, Brosinski, Christoph, Bubel, Nele, Búřil, Jiří, Čábal, Martin, Casado, Laura, Celis, Elena de, Chabert, Emmanuel, Charisse, Daniel, Cheng, Bastian, Chovanec, Vendelín, Cidlinsky, Peter, Cisár, Juraj, Clarençon, Fréderic, Crozier, Sophie, Čurdová, Nina, Damaskinos, Michele, Damgaard, Dorte, Daniš, Martin, Dazinger, Florian, Deb-Chatterji, Milani, Delalic, Asima, Delekta, Agnieszka, Delorme, Stephen, Deutschmann, Hannes, Diamandis, Elie, Diedrichsen, Tove, Doležalová, Irena, Dorn, Franziska, du Mesnil de Rochemont, Richard, DupontHougaard, Kristina, Ebrahimi, Taraneh, Eff, Florian, Eliášová, Ilona, Enriquez, Brian, Ergawy, Mostafa, Essig, Fabian, Falkesgaard, Maiken, Fandler-Höfler, Simon, Fernández, Andrés, Ferré, Jean-Christophe, Ferrier, Anna, Fiehler, Jens, Figlewski, Krystian, Fischer, Sebastian, Fischer, Urs, Flottmann, Fabian, Forbig, Robert, Förch, Christian, Fromm, Annette, Fuentes, Blanca, Gaedke, Ines, Galczak, Romana, Galijasevic, Malik, Ganser, Bernhard, Gattringer, Thomas, Gawlitza, Matthias, Gelhard, Sarah, Gellißen, Susanne, Gerber, Johannes, Giannakakis, Michail Panagiotis, Gindlhuber, Karin, Gizewski, Elke R., Glodny, Bernhard, Godel, Tim, Goebell, Einar, Goldemund, David, Görtler, Michael, Goyal, Mayank, Grams, Astrid E., Gruber, Joachim, Gruber, Katharina, Günthner-Lengsfeld, Thomas, Haase, Kathrin, Hacker-Ivan, Floriana, Hallerstig, Erika, Hanning, Uta, Haring, Jozef, Haršány, Michal, Haršány, Ján, Hartmann, Christian, Hassler, Eva Maria, Hauptmann, Kristina, Häusler, Karl Georg, Hecker, Constantin, Hellstern, Victoria, Henkes, Hans, Hernández, Victoria, Herweh, Christian, Hilgenfeld, Tim, Hill, Michael D., Hjort, Niels, HjortJensen, Nina, Hoelter, Maya, Hoffmann, Karl-Titus, Holst, Brigitte, Holtmannspoetter, Markus, Hopf-Jensen, Silke, Hoppe, Julia, Horner, Susanne, HougaardSoerensen, Leif, Hua, Vi Tuan, Hubert, Alexander, Hurtíková, Eva, Jakubíček, Stanislava, Janjic, Tanja, Jaramillo, Kirsten, Jedlitschka, Angela, Jensen, Schiela, Jensen, Märit, Jesser, Jessica, Jestaedt, Leonie, Johnson, Sabine, Jonszta, Tomáš, Kalmar, Peter, Karabegovic, Sanja, Karen, Kollo, Kastrup, Andreas, Katja, Hopp, Keeba, Natalia, Keese, Petra, Kefalaykos, Christina, Keil, Fee, Kellert, Lars, Kellinghaus, Christoph, Kestner, Roxane-Isabelle, Kiechl, Stefan, Killer-Oberpfalzer, Monika, Klepanec, Andrej, Knispel, Casjupea, Knoflach, Michael, Kohler, Sabine, Kohlhase, Konstantin, Kollikowski, Alexander Marco, Kovář, Martin, Krajina, Antonín, Kral, Michael, Krastev, Georgi, Krause, Lars Udo, Kreidenhuber, Rudolf, Křivka, Tomáš, Krkoška, Adam, Kröger, Jan Robert, Kronlage, Moritz, Krukowski, Pawel, Kühn, Julia, Kurča, Egon, Kurka, Natalia, Kuschnerow, Michael, Lachmund, Rita, Lamprecht, Susanne, Lange, Rüdiger, Lauer, Monika, Leciñana, Alonso de, Leder, Sara, Leger, Anne, Lehnen, Nils, Lehrieder, Dominik, Leißner, Maximilian, Leitinger, Markus, Leitner, Ursula, Lenck, Stéphanie, Lenzenweger, Eva, Liebig, Thomas, Lowens, Stephan, Lunzer, Manuel, Maegerlein, Christian, Magyar, Marton, Marques, Leonardo, Matyáš, David, Maurer, Gabriele, Mauritz, Matthias, Maximilian, Thormann, Mayer-Süß, Lukas, Meckel, Stephan, Medek, Oldřich, Meissner, Julius N., Mencl, Pavel, Merkle, Andrea, Mesche, Birte, Michalski, Dominik, Mikulík, Robert, Modrau, Boris, Möhlenbruch, Markus A., Mohr, Alexander, Mönninghoff, Christoph, Moser, Tobias, Mücke, Ramona, Müller-Hülsbeck, Stefan, Müller-Thies-Broussalis, Erasmia, Mutzenbach, Sebastian, Navia, Pedro, Neuberger, Ulf, Neugebauer, Hermann, Neumann, Jens, Nguyên, Anh, Niederkorn, Kurt, Nosál', Vladimír, Novobilský, Richard, Ntoulias, Nikos, Nussbaum, Lukas, Oder, Joanna, Oldag, Andreas, Ondrejkovič, Marián, Otto, Ferdinand, Otto, Dagmar, Paech, Daniel, Pagano, Paolo, Pallesen, Lars-Peder, Panský, Michal, Papanagiotou, Panagiotis, Patrick, Samp, Paukisch, Harald, Pelz, Johann, Petersen, Inga, Petersen, Martina, Petzold, Gabor C., Pfaff, Johannes, Pfeilschifter, Waltraud, Pham, Mirko, Pichler, Alexander, Pierot, Laurent, Pikija, Slaven, PlougmannPovlsen, Jan, Polkowski, Christoph, Polomac, Nenad, Portugaller, Rupert Horst, Poulsen, Marika, Preiß, Michael, Premat, Kévin, Prestsæter, Sjur, Prieto-Pérez, Rocio, Psychogios, Marios, Puetz, Volker, Purrucker, Jan, Rai, Heike, Rauch, Maximilian, Raupach, Jan, Reimann, Gernot, Reimann, Georg, Reitz, Sarah, Renc, Ondřej, Retzlaff, Jasmin, Rigual, Ricardo, Ringleb, Peter Arthur, Rivera-Bengoa, Carlota, Rodríguez, Jorge, Rohde, Stefan, Rohler, Siegfried, Rosso, Charlotte, Roth, Christian, Röttcher, Thomas, Roubec, Martin, Roztočilová, Milada, Rudnicka, Svetlana, Ruiz, Gerardo, Ryan, Stephen, Ryckborst, Karla J., Sandvik, Simen, Schäfer, Jan-Hendrik, Schaller-Paule, Martin, Schell, Maximillian, Schellinger, Peter, Schlemm, Eckhard, Schmid, Florian, Schmidt, Christoph, Schmitz, Marie Louise, Schneider, Claus, Scholtz, Jan-Erik, Schönenberger, Silvia, Schröter, Andreas, Schwarz, Daniel, Schwarz, Stephan, Schwarzenhofer, Daniel, Seifert-Held, Thomas, Seiler, Alexander, Seker, Fatih, Shotar, Eimad, Simonsen, Claus Z., Simonsen, Maria Theresa, Sivák, Jozef, Skagen, Karolina, Skjelland, Mona, Šnajdrová, Alena, Solymosi, Lazlo, Sømark, Jesper, Sonnberger, Michael, Soršák, Jakub, Sourour, Nader, Søyland, Jogrim, Spitzer, Daniel, Sporns, Peter, Städt, Michael, Steidl, Eike, Størdal, Anne Margrethe Kaalaas, Stösser, Sebastian, Strickmann, Sarah, Strýček, Ondřej, Suškevič, Igor, Sýkora, Jan, Tennøe, Bjørn, Thaler, Daniela, Theisen, Sara, Thomalla, Götz, Trendafilov, Petar, Trenkler, Johannes, Trumm, Christoph, Tsogkas, Ioannis, Tunold, Jon-Anders, Tveit, Lars, Ulfert, Christian, Vališ, Kateřina, Vaníček, Jiří, Vassilev, Christine, Vítková, Eva, Voit-Höhne, Heinz-Leonhard, Vojtíšek, Bohuslav, Volderauer, Karoline, Vollherbst, Dominik, Vollmuth, Christoph, Volna, Kamila, Volný, Ondřej, VonWeitzel-Mudersbach, Poul, Vorčák, Martin, Wagner, Marlies, Wathle, Gaute Kjellevold, Weber, Werner, Weber, Anushe, Weiss, Viktor, Weller, Johannes M., Wenger-Alakmeh, Katharina, Weyland, Cyrill, Weymayr, Friedrich, Wießpeiner, Ulrike, Willeit, Johannes, Wittwer, Aymeric, Wollenweber, Frank, Wortmann, Ginette, Wunderlich, Silke, Xiong, Yanyan, You, Se-Jong, ZachoSpeiser, Lasse, Zelenak, Kamil, Zeleňáková, Jana, Zubel, Seraphine, Subtil, Fabien, Gizewski, Elke R, Hill, Michael D, Krajina, Antonin, Simonsen, Claus Z, Zeleňák, Kamil, Blauenfeldt, Rolf A, Denis, Angélique, Gerber, Johannes C, Keil, Christiane Fee, Mikkelsen, Ronni, Möhlenbruch, Markus, Münnich, Nico, Petzold, Gabor C, Schell, Maximilian, Vollherbst, Dominik F, and Wick, Wolfgang

Published
2023
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3. Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design

Author

Wachter, Rolf, Gröschel, Klaus, Wasser, Katrin, Uhe, Tobias, Schäbitz, Wolf-Rüdiger, Köhrmann, Martin, Dichgans, Martin, Gröschel, Sonja, Uphaus, Timo, Hahn, Marianne, Zuhorn, Frederic, Wulff, Leonard, Plümer, Jorge, Kok, Lena, Janz, Marcel, Kitsiou, Alkisti, Gehmeyr, Julian, Dabbagh, Alhuda, Huber, Charlotte, Pelz, Johann, Wartenberg, Katja, Michalski, Dominik, Seidel, Mirko, Flissakowski, Oscar, Goschenhofer, Anna, Hussain, Rabia-Basari, Kim, Ina, Kinze, Stephan, Kroneberger, Christian, Lingnau, Michale, Lischewski, Dennis, Muhn, Florian, Rogge, Witold, Schieffer, Miriam, Setayesh-Roonizi, Anuscheh, Sparenberg, Paul, Schertel, Jill Marie, Ringleb, Peter, Purrucker, Jan, Berberich, Anne, Heyse, Miriam, Ungerer, Matthias, Bauer, Gregor, Reichardt, Christine, Etgen, Thorleif, Ebel, Bernhard, Milanković-Eberl, Dragana, Schwarte, Olav, Höcherl, Constanze, Asch, Eric-Manuel, Bojtschuk, Luisa, Frey, Maximilian, Dlouhy, Tomas, Ertl, Michael, Zickler, Philipp Patrick, Beier, Barbara, Braadt, Lino-Dominic, Gabrielyan, Inessa, Kermer, Pawel, Kaste, Matthias, Anter, Ahmed, Stirbulescu, Corina, Meleshchenco, Nataliia, Burgholte, Friederike, Lüers, Claus, Steiner, Thorsten, Cierpinski, Mari-Carmen, Lichti, Bethke, Florian, Bonowski, Lars, Eid, Hassan Abou, Vajda-Medina, Esteban, Probst, Mareike, Essa, Hisham, Frank, Benedikt, Stolte, Benjamin, Milles, Lennart, Soda, Hassan, Hiermann, Erich, Rascher, Renate Weinhardt Alexandra, Stan, Marius, Kääb, Stefan, Kellert, Lars, Dimitriadis, Konstantinos, Kopczak, Anna, Küster, Bettina, Sinner, Moritz, Steiger, Ignaz, Kaffe, Maria, Clauß, Sebastian, Janowitz, Daniel, Thaler, Raffael, Schellinger, Peter, Glahn, Jörg, Schubert, Jan, Jenniges, Simone, Markmann-Boenke, Silke, Putzer, Anne-Sophie, Straeten, Michael Schwarze Vera, Wiemer, Marcus, Kallmünzer, Bernd, Macha, Kosmas, Haupenthal, David, Balk, Stefanie, Kossel, Clara-Sophie, Häusler, Georg, Lehrieder, Dominik, Cidlinsky, Peter, Hametner, Christian, Vogl, Christine, Fischer, Thomas, Huttelmaier, Moritz, Nordbeck, Octavian Maniuc Peter, von Hardenberg, Albrecht, Jünemann, Martin, Braun, Tobias, Viard, Maxime, Gerner, Stefan, Omar, AlHaj, Genau, Sonja, Olbricht, Linus, Wassenberg, Matthias, Langguth, Niklas, Fräbel, Christian, Baumgart, Romy, Kalra, Love-Preet, Diel, Norma, Hoffmann, Frank, Kraft, Andrea, Schönmuth, Bettine, Giebler, Anja, Weber, Lorenz, Grond, Martin, Birringer, Jan, Lichte-Schneider, Sandra, Hütwohl, Daniela, Krause, Lars Udo, Petersen, Martina, Althaus, Katharina, Kirchmeier, Konstantin, Novikova, Liubov, Müller, Susanne, Schellong, Sebastian, Brudzinski, Mirko, Gerk, Ulrich, Palisch, Holger, Heinzel, Frank R., Fett, Jana, Suntha, Avinash, Burian, Katja, Schmitz, Bettina, Gutwinski, Anna, Angermüller, Veronika, Alhammoud, Tameem, Cakiroglu, Hüsniye, Bach, Ullrich, Nabavi, Darius, Offermann, Jens, Crome, Olaf, Dimitrijeski, Boris, Meincke, Carsten, Hamann, Gerhard, Alber, Burkhard, Müller, Robert, Pallesen, Lars-Peder, Pütz, Volker, Hartmann, Christian, Berrouschot, Jörg, Stoll, Anett, Keilitz, Janina, Klunk, Dietrich, Voigt, Roman, Kastrup, Andreas, Schröter, Andreas, Schmucker, Johannes, Pfeilschifter, Waltraud, Krämer, Christoffer, Wiemers, Milena, Simon, Micha, Finke, Alexander, Weiß, Christian, Hobohm, Carsten, Naupold, Katrin, Bley-Renning, Karen, Winter, Sabrina, Poli, Sven, Mengel, Annerose, Poli, Khouloud, Expósito, Alexandra Gómez, Mbroh, Joshua, Tieck, Maria, Rosenkranz, Michael, Boskamp, Stefan, Ritter, Nicolas, Seibel, Lena, Schöps, Christian, Ketzler, Rebecca, Nägele, Herbert, Sydow, Karsten, Kurka, Natalia, Schäfer, Jan Hendrik, Charisse, Daniel, Gruber, Katharina, Kohlhase, Konstantin, Lieschke, Franziska, Operhalski, Felix, Seiler, Alexander, Petzold, Gabor, Bode, Felix Jürgen, Stösser, Sebastian, Meißner, Julius, Ebrahimi, Taraneh, Nordsiek, Julia, Beckonert, Niklas, Weissenborn, Karin, Große, Gerrit Maximilian, Worthmann, Hans, Hennemann, Ann-Katrin, Jochmann, Svenja, Gründahl, Julius, Al-Ayoubi, Jana, Ernst, Johanna, Bähr, Oliver, Gruber, Herbert, Benesch, Sonka, Pollinger, Thomas, Alachkar, Nawar, Busch, Sonia, Butz, Steffi, Forkmann, Mathias, Mahnkopf, Christian, Mischke, Thomas, Schnupp, Steffen, Thomalla, Götz, Deb-Chatterji, Milani, Cheng, Bastian, Gelderblom, Mathias, Hoppe, Julia, Jensen, Märit, Schell, Maximilian, Schlemm, Eckhard, Marquardt, Lars, Kazarians, Haiko, Rheingans, Pia Franziska, Hötzer, Kai, Rose, Dietmar, Neumann-Haefelin, Tobias, Berthel, Jörg, Alijaj, Lirim, Krug, Joachim, Niethammer, Margit, Szöllösi, Géza-Attila, Obermann, Marc, Adochitei, Nicoletta, Strik, Herwig, Lenz, Arne, Steigerwald, Frank, Müller, Jörg, Honermann, Martin, Burgstaller, Marian Christoph, Kollmar, Rainer, Rashid, Maryam, Ganai, Ahmad Ajaz, Ossendorf, Saric, Majda, Tischer, Karl-Heinz, Toluli, Adela, Wollenweber, Frank Arne, Rahban, Laya, Silva, Thais Portugal, Lee, Miri, Grosch, Matthias Julius, Minnerup, Jens, Liman, Jan, Nückel, Martin, Böhm, Magdalena, Weber-Krüger, Mark, Brachmann, Johannes, Laufs, Ulrich, Gelbrich, Götz, Petroff, David, Prettin, Christiane, Schellinger, Peter D., Hamann, Gerhard F., Mende, Meinhard, and Wagner, Marcus

Published
2023
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4. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial

Author

Alonso, Angelika, Arquizan, Caroline, Barreau, Xavier, Beaujeux, Rémy, Behme, Daniel, Boeckh-Behrens, Tobias, Boehme, Christian, Boix, Martí, Boulouis, Grégoire, Bricout, Nicolas, Broc, Nicolas, Cereda, Carlo W., Chabert, Emmanuel, Cho, Tae-Hee, Cianfoni, Alessandro, Costalat, Vincent, Denier, Christian, Di Maria, Frederico, du Mesnil de Rochemont, Richard, Fearon, Patricia, Ferrier, Anna, Fischer, Sebastian, Gauberti, Maxime, Gaudron, Marie, Gimenez, Laetitia, Globas, Christoph, Görtler, Michael, Goyal, Mayank, Hilker-Roggendorf, Ruediger, Hill, Michael D., Hua, Vi Tuan, Humbertjean, Lisa, Jansen, Olav, Jung, Simon, Kägi, Georg, Kelly, Michael E., Kleffner, Ilka, Knoflach, Michael, Nedeltchev, Krassen, Krause, Lars Udo, Lappalainen, Kimmo, Lefebvre, Margaux, Leyon, Joe, Liao, Liang, Liegey, Jean-Sebastien, Loehr, Christian, Michel, Patrik, Nannoni, Stefania, Nicholson, Patrick, Nico, Lorena, Obadia, Michael, Ognard, Julien, Ogungbemi, Ayokunle, Olivot, Jean-Marc, Escalard, Simon, Pasi, Marco, Peeling, Lissa, Perez, Jane, Petersen, Martina, Piechowiak, Eike, Raposo, Roberto, Räty, Silja, Reitz, Sarah C., Remollo, Sebastià, Remonda, Luca, Rennie, Ian, Requena, Manuel, Riabikin, Alexander, Riva, Roberto, Rouchaud, Aymeric, Rosi, Andrea, Rubiera, Marta, Spelle, Laurent, Schnieder, Marlena, Schaafsma, Joanna D., Schubert, Tilman, Schulz, Jörg B., Siddiqui, Mohammed, Soize, Sébastien, Sonnberger, Michael, Touze, Emmanuel, Triquenot, Aude, Turc, Guillaume, Vieira, Lucy, Ben Hassen, Wagih, Wagner, Judith N., Wasser, Katrin, Weber, Johannes, Wenz, Holger, Weisenburger-Lile, David, Wodarg, Fritz, Wolff, Valérie, Wunderlich, Silke, Fischer, Urs, Kaesmacher, Johannes, Strbian, Daniel, Eker, Omer, Cognard, Christoph, Plattner, Patricia S, Bütikofer, Lukas, Mordasini, Pasquale, Deppeler, Sandro, Pereira, Vitor M, Albucher, Jean François, Darcourt, Jean, Bourcier, Romain, Benoit, Guillon, Papagiannaki, Chrysanthi, Ozkul-Wermester, Ozlem, Sibolt, Gerli, Tiainen, Marjaana, Gory, Benjamin, Richard, Sébastien, Liman, Jan, Ernst, Marielle Sophie, Boulanger, Marion, Barbier, Charlotte, Mechtouff, Laura, Zhang, Liqun, Marnat, Gaultier, Sibon, Igor, Nikoubashman, Omid, Reich, Arno, Consoli, Arturo, Lapergue, Bertrand, Ribo, Marc, Tomasello, Alejandro, Saleme, Suzana, Macian, Francisco, Moulin, Solène, Pagano, Paolo, Saliou, Guillaume, Carrera, Emmanuel, Janot, Kevin, Hernández-Pérez, María, Pop, Raoul, Schiava, Lucie Della, Luft, Andreas R, Piotin, Michel, Gentric, Jean Christophe, Pikula, Aleksandra, Pfeilschifter, Waltraud, Arnold, Marcel, Siddiqui, Adnan H, Froehler, Michael T, Furlan, Anthony J, Chapot, René, Wiesmann, Martin, Machi, Paolo, Diener, Hans-Christoph, Kulcsar, Zsolt, Bonati, Leo H, Bassetti, Claudio L, Mazighi, Mikael, Liebeskind, David S, Saver, Jeffrey L, and Gralla, Jan

Published
2022
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5. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial

Author

Bendszus, Martin, primary, Fiehler, Jens, additional, Subtil, Fabien, additional, Bonekamp, Susanne, additional, Aamodt, Anne Hege, additional, Fuentes, Blanca, additional, Gizewski, Elke R, additional, Hill, Michael D, additional, Krajina, Antonin, additional, Pierot, Laurent, additional, Simonsen, Claus Z, additional, Zeleňák, Kamil, additional, Blauenfeldt, Rolf A, additional, Cheng, Bastian, additional, Denis, Angélique, additional, Deutschmann, Hannes, additional, Dorn, Franziska, additional, Flottmann, Fabian, additional, Gellißen, Susanne, additional, Gerber, Johannes C, additional, Goyal, Mayank, additional, Haring, Jozef, additional, Herweh, Christian, additional, Hopf-Jensen, Silke, additional, Hua, Vi Tuan, additional, Jensen, Märit, additional, Kastrup, Andreas, additional, Keil, Christiane Fee, additional, Klepanec, Andrej, additional, Kurča, Egon, additional, Mikkelsen, Ronni, additional, Möhlenbruch, Markus, additional, Müller-Hülsbeck, Stefan, additional, Münnich, Nico, additional, Pagano, Paolo, additional, Papanagiotou, Panagiotis, additional, Petzold, Gabor C, additional, Pham, Mirko, additional, Puetz, Volker, additional, Raupach, Jan, additional, Reimann, Gernot, additional, Ringleb, Peter Arthur, additional, Schell, Maximilian, additional, Schlemm, Eckhard, additional, Schönenberger, Silvia, additional, Tennøe, Bjørn, additional, Ulfert, Christian, additional, Vališ, Kateřina, additional, Vítková, Eva, additional, Vollherbst, Dominik F, additional, Wick, Wolfgang, additional, Thomalla, Götz, additional, Adamczewski, Olaf, additional, Alektoror, Kirill, additional, Alexander, März, additional, Alexandrou, Maria, additional, Alias, Quentin, additional, Al-Kuzae, Fadha Elawi, additional, Allard, Julien, additional, Al-Schameri, Rahman, additional, Álvarez, Alberto, additional, Andersen, Grethe, additional, AnkerlundBlaufeldt, Rolf, additional, Antje, Riedel, additional, Appelbohm, Hannes, additional, Argren, Maria, additional, Assmann, Anne, additional, Augustin, Michael, additional, Bach, Elke, additional, Bar, Michal, additional, Barleben, Maria, additional, Baronnet, Flore, additional, Barrios, Andrés, additional, Bavúzová, Xénia, additional, BayThomsen, Rikke, additional, Becker, Sandra, additional, Beer, Sylvia, additional, Behme, Daniel, additional, Bellut, Maximilian, additional, Bendszus, Martin, additional, Berkefeld, Joachim, additional, Bester, Maximillian, additional, Bode, Felix J., additional, Boehme, Christian, additional, Boese, Ramona, additional, Bohmann, Ferdinand, additional, Borggrefe, Jan, additional, Boss, Erendira Gabriela, additional, Boutchakova, Maria, additional, Boxhammer, Elfi, additional, Brandhofe, Annemarie, additional, Breckwoldt, Michael, additional, Brekenfeld, Casper, additional, Brehm, Alex, additional, Brem, Christian, additional, Breuer, Stella, additional, Breyer, Tobias, additional, Brodová, Petra, additional, Broocks, Gabriel, additional, Brosinski, Christoph, additional, Bubel, Nele, additional, Búřil, Jiří, additional, Čábal, Martin, additional, Casado, Laura, additional, Celis, Elena de, additional, Chabert, Emmanuel, additional, Charisse, Daniel, additional, Chovanec, Vendelín, additional, Cidlinsky, Peter, additional, Cisár, Juraj, additional, Clarençon, Fréderic, additional, Crozier, Sophie, additional, Čurdová, Nina, additional, Damaskinos, Michele, additional, Damgaard, Dorte, additional, Daniš, Martin, additional, Dazinger, Florian, additional, Deb-Chatterji, Milani, additional, Delalic, Asima, additional, Delekta, Agnieszka, additional, Delorme, Stephen, additional, Diamandis, Elie, additional, Diedrichsen, Tove, additional, Doležalová, Irena, additional, du Mesnil de Rochemont, Richard, additional, DupontHougaard, Kristina, additional, Ebrahimi, Taraneh, additional, Eff, Florian, additional, Eliášová, Ilona, additional, Enriquez, Brian, additional, Ergawy, Mostafa, additional, Essig, Fabian, additional, Falkesgaard, Maiken, additional, Fandler-Höfler, Simon, additional, Fernández, Andrés, additional, Ferré, Jean-Christophe, additional, Ferrier, Anna, additional, Figlewski, Krystian, additional, Fischer, Sebastian, additional, Fischer, Urs, additional, Forbig, Robert, additional, Förch, Christian, additional, Fromm, Annette, additional, Gaedke, Ines, additional, Galczak, Romana, additional, Galijasevic, Malik, additional, Ganser, Bernhard, additional, Gattringer, Thomas, additional, Gawlitza, Matthias, additional, Gelhard, Sarah, additional, Gerber, Johannes, additional, Giannakakis, Michail Panagiotis, additional, Gindlhuber, Karin, additional, Gizewski, Elke R., additional, Glodny, Bernhard, additional, Godel, Tim, additional, Goebell, Einar, additional, Goldemund, David, additional, Görtler, Michael, additional, Grams, Astrid E., additional, Gruber, Joachim, additional, Gruber, Katharina, additional, Günthner-Lengsfeld, Thomas, additional, Haase, Kathrin, additional, Hacker-Ivan, Floriana, additional, Hallerstig, Erika, additional, Hanning, Uta, additional, Haršány, Michal, additional, Haršány, Ján, additional, Hartmann, Christian, additional, Hassler, Eva Maria, additional, Hauptmann, Kristina, additional, Häusler, Karl Georg, additional, Hecker, Constantin, additional, Hellstern, Victoria, additional, Henkes, Hans, additional, Hernández, Victoria, additional, Hilgenfeld, Tim, additional, Hill, Michael D., additional, Hjort, Niels, additional, HjortJensen, Nina, additional, Hoelter, Maya, additional, Hoffmann, Karl-Titus, additional, Holst, Brigitte, additional, Holtmannspoetter, Markus, additional, Hoppe, Julia, additional, Horner, Susanne, additional, HougaardSoerensen, Leif, additional, Hubert, Alexander, additional, Hurtíková, Eva, additional, Jakubíček, Stanislava, additional, Janjic, Tanja, additional, Jaramillo, Kirsten, additional, Jedlitschka, Angela, additional, Jensen, Schiela, additional, Jesser, Jessica, additional, Jestaedt, Leonie, additional, Johnson, Sabine, additional, Jonszta, Tomáš, additional, Kalmar, Peter, additional, Karabegovic, Sanja, additional, Karen, Kollo, additional, Katja, Hopp, additional, Keeba, Natalia, additional, Keese, Petra, additional, Kefalaykos, Christina, additional, Keil, Fee, additional, Kellert, Lars, additional, Kellinghaus, Christoph, additional, Kestner, Roxane-Isabelle, additional, Kiechl, Stefan, additional, Killer-Oberpfalzer, Monika, additional, Knispel, Casjupea, additional, Knoflach, Michael, additional, Kohler, Sabine, additional, Kohlhase, Konstantin, additional, Kollikowski, Alexander Marco, additional, Kovář, Martin, additional, Krajina, Antonín, additional, Kral, Michael, additional, Krastev, Georgi, additional, Krause, Lars Udo, additional, Kreidenhuber, Rudolf, additional, Křivka, Tomáš, additional, Krkoška, Adam, additional, Kröger, Jan Robert, additional, Kronlage, Moritz, additional, Krukowski, Pawel, additional, Kühn, Julia, additional, Kurka, Natalia, additional, Kuschnerow, Michael, additional, Lachmund, Rita, additional, Lamprecht, Susanne, additional, Lange, Rüdiger, additional, Lauer, Monika, additional, Leciñana, Alonso de, additional, Leder, Sara, additional, Leger, Anne, additional, Lehnen, Nils, additional, Lehrieder, Dominik, additional, Leißner, Maximilian, additional, Leitinger, Markus, additional, Leitner, Ursula, additional, Lenck, Stéphanie, additional, Lenzenweger, Eva, additional, Liebig, Thomas, additional, Lowens, Stephan, additional, Lunzer, Manuel, additional, Maegerlein, Christian, additional, Magyar, Marton, additional, Marques, Leonardo, additional, Matyáš, David, additional, Maurer, Gabriele, additional, Mauritz, Matthias, additional, Maximilian, Thormann, additional, Mayer-Süß, Lukas, additional, Meckel, Stephan, additional, Medek, Oldřich, additional, Meissner, Julius N., additional, Mencl, Pavel, additional, Merkle, Andrea, additional, Mesche, Birte, additional, Michalski, Dominik, additional, Mikulík, Robert, additional, Modrau, Boris, additional, Möhlenbruch, Markus A., additional, Mohr, Alexander, additional, Mönninghoff, Christoph, additional, Moser, Tobias, additional, Mücke, Ramona, additional, Müller-Thies-Broussalis, Erasmia, additional, Mutzenbach, Sebastian, additional, Navia, Pedro, additional, Neuberger, Ulf, additional, Neugebauer, Hermann, additional, Neumann, Jens, additional, Nguyên, Anh, additional, Niederkorn, Kurt, additional, Nosál', Vladimír, additional, Novobilský, Richard, additional, Ntoulias, Nikos, additional, Nussbaum, Lukas, additional, Oder, Joanna, additional, Oldag, Andreas, additional, Ondrejkovič, Marián, additional, Otto, Ferdinand, additional, Otto, Dagmar, additional, Paech, Daniel, additional, Pallesen, Lars-Peder, additional, Panský, Michal, additional, Patrick, Samp, additional, Paukisch, Harald, additional, Pelz, Johann, additional, Petersen, Inga, additional, Petersen, Martina, additional, Petzold, Gabor C., additional, Pfaff, Johannes, additional, Pfeilschifter, Waltraud, additional, Pichler, Alexander, additional, Pikija, Slaven, additional, PlougmannPovlsen, Jan, additional, Polkowski, Christoph, additional, Polomac, Nenad, additional, Portugaller, Rupert Horst, additional, Poulsen, Marika, additional, Preiß, Michael, additional, Premat, Kévin, additional, Prestsæter, Sjur, additional, Prieto-Pérez, Rocio, additional, Psychogios, Marios, additional, Purrucker, Jan, additional, Rai, Heike, additional, Rauch, Maximilian, additional, Reimann, Georg, additional, Reitz, Sarah, additional, Renc, Ondřej, additional, Retzlaff, Jasmin, additional, Rigual, Ricardo, additional, Rivera-Bengoa, Carlota, additional, Rodríguez, Jorge, additional, Rohde, Stefan, additional, Rohler, Siegfried, additional, Rosso, Charlotte, additional, Roth, Christian, additional, Röttcher, Thomas, additional, Roubec, Martin, additional, Roztočilová, Milada, additional, Rudnicka, Svetlana, additional, Ruiz, Gerardo, additional, Ryan, Stephen, additional, Ryckborst, Karla J., additional, Sandvik, Simen, additional, Schäfer, Jan-Hendrik, additional, Schaller-Paule, Martin, additional, Schell, Maximillian, additional, Schellinger, Peter, additional, Schmid, Florian, additional, Schmidt, Christoph, additional, Schmitz, Marie Louise, additional, Schneider, Claus, additional, Scholtz, Jan-Erik, additional, Schröter, Andreas, additional, Schwarz, Daniel, additional, Schwarz, Stephan, additional, Schwarzenhofer, Daniel, additional, Seifert-Held, Thomas, additional, Seiler, Alexander, additional, Seker, Fatih, additional, Shotar, Eimad, additional, Simonsen, Claus Z., additional, Simonsen, Maria Theresa, additional, Sivák, Jozef, additional, Skagen, Karolina, additional, Skjelland, Mona, additional, Šnajdrová, Alena, additional, Solymosi, Lazlo, additional, Sømark, Jesper, additional, Sonnberger, Michael, additional, Soršák, Jakub, additional, Sourour, Nader, additional, Søyland, Jogrim, additional, Spitzer, Daniel, additional, Sporns, Peter, additional, Städt, Michael, additional, Steidl, Eike, additional, Størdal, Anne Margrethe Kaalaas, additional, Stösser, Sebastian, additional, Strickmann, Sarah, additional, Strýček, Ondřej, additional, Suškevič, Igor, additional, Sýkora, Jan, additional, Thaler, Daniela, additional, Theisen, Sara, additional, Trendafilov, Petar, additional, Trenkler, Johannes, additional, Trumm, Christoph, additional, Tsogkas, Ioannis, additional, Tunold, Jon-Anders, additional, Tveit, Lars, additional, Vaníček, Jiří, additional, Vassilev, Christine, additional, Voit-Höhne, Heinz-Leonhard, additional, Vojtíšek, Bohuslav, additional, Volderauer, Karoline, additional, Vollherbst, Dominik, additional, Vollmuth, Christoph, additional, Volna, Kamila, additional, Volný, Ondřej, additional, VonWeitzel-Mudersbach, Poul, additional, Vorčák, Martin, additional, Wagner, Marlies, additional, Wathle, Gaute Kjellevold, additional, Weber, Werner, additional, Weber, Anushe, additional, Weiss, Viktor, additional, Weller, Johannes M., additional, Wenger-Alakmeh, Katharina, additional, Weyland, Cyrill, additional, Weymayr, Friedrich, additional, Wießpeiner, Ulrike, additional, Willeit, Johannes, additional, Wittwer, Aymeric, additional, Wollenweber, Frank, additional, Wortmann, Ginette, additional, Wunderlich, Silke, additional, Xiong, Yanyan, additional, You, Se-Jong, additional, ZachoSpeiser, Lasse, additional, Zelenak, Kamil, additional, Zeleňáková, Jana, additional, and Zubel, Seraphine, additional

Published
2023
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6. Interaction between intravenous thrombolysis and clinical outcome between slow and fast progressors undergoing mechanical thrombectomy: a post-hoc analysis of the SWIFT-DIRECT trial.

Author

Marnat, Gaultier, Kaesmacher, Johannes, Buetikofer, Lukas, Sibon, Igor, Saleme, Suzana, Pop, Raoul, Henon, Hilde, Michel, Patrik, Mazighi, Mikaël, Kulcsar, Zsolt, Janot, Kevin, Machi, Paolo, Pikula, Aleksandra, Gentric, Jean-Christophe, Hernández-Pérez, María, Krause, Lars Udo, Turc, Guillaume, Liebeskind, David S., Gralla, Jan, and Fischer, Urs

Subjects
STATISTICS, INTRAVENOUS therapy, CONFIDENCE intervals, ISCHEMIC stroke, INTRACRANIAL hemorrhage, THROMBOLYTIC therapy, THROMBECTOMY, DESCRIPTIVE statistics, DATA analysis, ODDS ratio, TISSUE plasminogen activator, SECONDARY analysis
Abstract

Background In proximal occlusions, the effect of reperfusion therapies may differ between slow or fast progressors. We investigated the effect of intravenous thrombolysis (IVT) (with alteplase) plus mechanical thrombectomy (MT) versus thrombectomy alone among slow versus fast stroke progressors. Methods The SWIFT-DIRECT trial data were analyzed: 408 patients randomized to IVT+MT or MT alone. Infarct growth speed was defined by the number of points of decay in the initial Alberta Stroke Program Early CT Score (ASPECTS) divided by the onset-to-imaging time. The primary endpoint was 3-month functional independence (modified Rankin scale 0-2). In the primary analysis, the study population was dichotomized into slow and fast progressors using median infarct growth velocity. Secondary analysis was also conducted using quartiles of ASPECTS decay. Results We included 376 patients: 191 IVT+MT, 185 MT alone; median age 73 years (IQR 65-81); median initial National Institutes of Health Stroke Scale (NIHSS) 17 (IQR 13-20). The median infarct growth velocity was 1.2 points/hour. Overall, we did not observe a significant interaction between the infarct growth speed and the allocation to either randomization group on the odds of favourable outcome (P=0.68). In the IVT+MT group, odds of any intracranial hemorrhage (ICH) were significantly lower in slow progressors (22.8% vs 36.4%; OR 0.52, 95% CI 0.27 to 0.98) and higher among fast progressors (49.4% vs 26.8%; OR 2.62, 95% CI 1.42 to 4.82) (P value for interaction <0.001). Similar results were observed in secondary analyses. Conclusion In this SWIFT-DIRECT subanalysis, we did not find evidence for a significant interaction of the velocity of infarct growth on the odds of favourable outcome according to treatment by MT alone or combined IVT+MT. However, prior IVT was associated with significantly reduced occurrence of any ICH among slow progressors whereas this was increased in fast progressors. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Effect of anesthetic strategies on distal stroke thrombectomy in the anterior and posterior cerebral artery

Author

Meyer, Lukas, primary, Stracke, Christian Paul, additional, Broocks, Gabriel, additional, Wallocha, Marta, additional, Elsharkawy, Mohamed, additional, Sporns, Peter B, additional, Piechowiak, Eike I, additional, Kaesmacher, Johannes, additional, Maegerlein, Christian, additional, Hernandez Petzsche, Moritz Roman, additional, Zimmermann, Hanna, additional, Naziri, Weis, additional, Abdullayev, Nuran, additional, Kabbasch, Christoph, additional, Behme, Daniel, additional, Thormann, Maximilian, additional, Maus, Volker, additional, Fischer, Sebastian, additional, Möhlenbruch, Markus A, additional, Weyland, Charlotte Sabine, additional, Langner, Soenke, additional, Ernst, Marielle, additional, Jamous, Ala, additional, Meila, Dan, additional, Miszczuk, Milena, additional, Siebert, Eberhard, additional, Lowens, Stephan, additional, Krause, Lars Udo, additional, Yeo, Leonard LL, additional, Tan, Benjamin Y Q, additional, Gopinathan, Anil, additional, Gory, Benjamin, additional, Galvan Fernandez, Jorge, additional, Schüller Arteaga, Miguel, additional, Navia, Pedro, additional, Raz, Eytan, additional, Shapiro, Maksim, additional, Arnberg, Fabian, additional, Zeleňák, Kamil, additional, Martínez-Galdámez, Mario, additional, Alexandrou, Maria, additional, Kastrup, Andreas, additional, Papanagiotou, Panagiotis, additional, Dorn, Franziska, additional, Kemmling, André, additional, Psychogios, Marios-Nikos, additional, Andersson, Tommy, additional, Chapot, René, additional, Fiehler, Jens, additional, and Hanning, Uta, additional

Published
2023
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8. Interaction between intravenous thrombolysis and clinical outcome between slow and fast progressors undergoing mechanical thrombectomy: a post-hoc analysis of the SWIFT-DIRECT trial

Author

Marnat, Gaultier, primary, Kaesmacher, Johannes, additional, Buetikofer, Lukas, additional, Sibon, Igor, additional, Saleme, Suzana, additional, Pop, Raoul, additional, Henon, Hilde, additional, Michel, Patrik, additional, Mazighi, Mikaël, additional, Kulcsar, Zsolt, additional, Janot, Kevin, additional, Machi, Paolo, additional, Pikula, Aleksandra, additional, Gentric, Jean-Christophe, additional, Hernández-Pérez, María, additional, Krause, Lars Udo, additional, Turc, Guillaume, additional, Liebeskind, David S, additional, Gralla, Jan, additional, and Fischer, Urs, additional

Published
2023
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9. Thrombectomy versus Medical Management for Isolated Anterior Cerebral Artery Stroke: An International Multicenter Registry Study

Author

Meyer, Lukas, Stracke, Paul, Broocks, Gabriel, Elsharkawy, Mohamed, Sporns, Peter, Piechowiak, Eike I, Kaesmacher, Johannes, Maegerlein, Christian, Hernandez Petzsche, Moritz Roman, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Diamandis, Elie, Thormann, Maximilian, Maus, Volker, Fischer, Sebastian, Möhlenbruch, Markus, Weyland, Charlotte S, Ernst, Marielle, Jamous, Ala, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard, Tan, Benjamin, Gopinathan, Anil, Arenillas-Lara, Juan F, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zeleňák, Kamil, Martínez-Galdámez, Mario, Alexandrou, Maria, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, André, Dorn, Franziska, Psychogios, Marios, Andersson, Tommy, Chapot, René, Fiehler, Jens, and Hanning, Uta

Subjects
610 Medizin und Gesundheit
Abstract

Background Evidence supporting a potential benefit of thrombectomy for distal medium vessel occlusions (DMVOs) of the anterior cerebral artery (ACA) is, to the knowledge of the authors, unknown. Purpose To compare the clinical and safety outcomes between mechanical thrombectomy (MT) and best medical treatment (BMT) with or without intravenous thrombolysis for primary isolated ACA DMVOs. Materials and Methods Treatment for Primary Medium Vessel Occlusion Stroke, or TOPMOST, is an international, retrospective, multicenter, observational registry of patients treated for DMVO in daily practice. Patients treated with thrombectomy or BMT alone for primary ACA DMVO distal to the A1 segment between January 2013 and October 2021 were analyzed and compared by one-to-one propensity score matching (PSM). Early outcome was measured by the median improvement of National Institutes of Health Stroke Scale (NIHSS) scores at 24 hours. Favorable functional outcome was defined as modified Rankin scale scores of 0-2 at 90 days. Safety was assessed by the occurrence of symptomatic intracerebral hemorrhage and mortality. Results Of 154 patients (median age, 77 years; quartile 1 [Q1] to quartile 3 [Q3], 66-84 years; 80 men; 94 patients with MT; 60 patients with BMT) who met the inclusion criteria, 110 patients (median age, 76 years; Q1-Q3, 67-83 years; 50 men; 55 patients with MT; 55 patients with BMT) were matched. DMVOs were in A2 (82 patients; 53%), A3 (69 patients; 45%), and A3 (three patients; 2%). After PSM, the median 24-hour NIHSS point decrease was -2 (Q1-Q3, -4 to 0) in the thrombectomy and -1 (Q1-Q3, -4 to 1.25) in the BMT cohort (P = .52). Favorable functional outcome (MT vs BMT, 18 of 37 [49%] vs 19 of 39 [49%], respectively; P = .99) and mortality (MT vs BMT, eight of 37 [22%] vs 12 of 39 [31%], respectively; P = .36) were similar in both groups. Symptomatic intracranial hemorrhage occurred in three (2%) of 154 patients. Conclusion Thrombectomy appears to be a safe and technically feasible treatment option for primary isolated anterior cerebral artery occlusions in the A2 and A3 segment with clinical outcomes similar to best medical treatment with and without intravenous thrombolysis. © RSNA, 2023 Supplemental material is available for this article. See also the editorial by Zhu and Wang in this issue.

Published
2023
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10. Effect of anesthetic strategies on distal stroke thrombectomy in the anterior and posterior cerebral artery

Author

Meyer, Lukas, Stracke, Christian Paul, Broocks, Gabriel, Wallocha, Marta, Elsharkawy, Mohamed, Sporns, Peter B, Piechowiak, Eike I, Kaesmacher, Johannes, Maegerlein, Christian, Hernandez Petzsche, Moritz Roman, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Thormann, Maximilian, Maus, Volker, Fischer, Sebastian, Mo¨hlenbruch, Markus A, Weyland, Charlotte Sabine, Langner, Soenke, Ernst, Marielle, Jamous, Ala, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard LL, Tan, Benjamin Y Q, Gopinathan, Anil, Gory, Benjamin, Galvan Fernandez, Jorge, Schu¨ller Arteaga, Miguel, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zeleňák, Kamil, Martínez-Galdámez, Mario, Alexandrou, Maria, Kastrup, Andreas, Papanagiotou, Panagiotis, Dorn, Franziska, Kemmling, André, Psychogios, Marios-Nikos, Andersson, Tommy, Chapot, René, Fiehler, Jens, and Hanning, Uta

Abstract

BackgroundNumerous questions regarding procedural details of distal stroke thrombectomy remain unanswered. This study assesses the effect of anesthetic strategies on procedural, clinical and safety outcomes following thrombectomy for distal medium vessel occlusions (DMVOs).MethodsPatients with isolated DMVO stroke from the TOPMOST registry were analyzed with regard to anesthetic strategies (ie, conscious sedation (CS), local (LA) or general anesthesia (GA)). Occlusions were in the P2/P3 or A2–A4 segments of the posterior and anterior cerebral arteries (PCA and ACA), respectively. The primary endpoint was the rate of complete reperfusion (modified Thrombolysis in Cerebral Infarction score 3) and the secondary endpoint was the rate of modified Rankin Scale score 0–1. Safety endpoints were the occurrence of symptomatic intracranial hemorrhage and mortality.ResultsOverall, 233 patients were included. The median age was 75 years (range 64–82), 50.6% (n=118) were female, and the baseline National Institutes of Health Stroke Scale score was 8 (IQR 4–12). DMVOs were in the PCA in 59.7% (n=139) and in the ACA in 40.3% (n=94). Thrombectomy was performed under LA±CS (51.1%, n=119) and GA (48.9%, n=114). Complete reperfusion was reached in 73.9% (n=88) and 71.9% (n=82) in the LA±CS and GA groups, respectively (P=0.729). In subgroup analysis, thrombectomy for ACA DMVO favored GA over LA±CS (aOR 3.07, 95% CI 1.24 to 7.57, P=0.015). Rates of secondary and safety outcomes were similar in the LA±CS and GA groups.ConclusionLA±CS compared with GA resulted in similar reperfusion rates after thrombectomy for DMVO stroke of the ACA and PCA. GA may facilitate achieving complete reperfusion in DMVO stroke of the ACA. Safety and functional long-term outcomes were comparable in both groups.

Published
2024
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11. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial

Author

Fischer, Urs, primary, Kaesmacher, Johannes, additional, Strbian, Daniel, additional, Eker, Omer, additional, Cognard, Christoph, additional, Plattner, Patricia S, additional, Bütikofer, Lukas, additional, Mordasini, Pasquale, additional, Deppeler, Sandro, additional, Pereira, Vitor M, additional, Albucher, Jean François, additional, Darcourt, Jean, additional, Bourcier, Romain, additional, Benoit, Guillon, additional, Papagiannaki, Chrysanthi, additional, Ozkul-Wermester, Ozlem, additional, Sibolt, Gerli, additional, Tiainen, Marjaana, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Liman, Jan, additional, Ernst, Marielle Sophie, additional, Boulanger, Marion, additional, Barbier, Charlotte, additional, Mechtouff, Laura, additional, Zhang, Liqun, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Nikoubashman, Omid, additional, Reich, Arno, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Ribo, Marc, additional, Tomasello, Alejandro, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Moulin, Solène, additional, Pagano, Paolo, additional, Saliou, Guillaume, additional, Carrera, Emmanuel, additional, Janot, Kevin, additional, Hernández-Pérez, María, additional, Pop, Raoul, additional, Schiava, Lucie Della, additional, Luft, Andreas R, additional, Piotin, Michel, additional, Gentric, Jean Christophe, additional, Pikula, Aleksandra, additional, Pfeilschifter, Waltraud, additional, Arnold, Marcel, additional, Siddiqui, Adnan H, additional, Froehler, Michael T, additional, Furlan, Anthony J, additional, Chapot, René, additional, Wiesmann, Martin, additional, Machi, Paolo, additional, Diener, Hans-Christoph, additional, Kulcsar, Zsolt, additional, Bonati, Leo H, additional, Bassetti, Claudio L, additional, Mazighi, Mikael, additional, Liebeskind, David S, additional, Saver, Jeffrey L, additional, Gralla, Jan, additional, Alonso, Angelika, additional, Arquizan, Caroline, additional, Barreau, Xavier, additional, Beaujeux, Rémy, additional, Behme, Daniel, additional, Boeckh-Behrens, Tobias, additional, Boehme, Christian, additional, Boix, Martí, additional, Boulouis, Grégoire, additional, Bricout, Nicolas, additional, Broc, Nicolas, additional, Cereda, Carlo W., additional, Chabert, Emmanuel, additional, Cho, Tae-Hee, additional, Cianfoni, Alessandro, additional, Costalat, Vincent, additional, Denier, Christian, additional, Di Maria, Frederico, additional, du Mesnil de Rochemont, Richard, additional, Fearon, Patricia, additional, Ferrier, Anna, additional, Fischer, Sebastian, additional, Gauberti, Maxime, additional, Gaudron, Marie, additional, Gimenez, Laetitia, additional, Globas, Christoph, additional, Görtler, Michael, additional, Goyal, Mayank, additional, Hilker-Roggendorf, Ruediger, additional, Hill, Michael D., additional, Hua, Vi Tuan, additional, Humbertjean, Lisa, additional, Jansen, Olav, additional, Jung, Simon, additional, Kägi, Georg, additional, Kelly, Michael E., additional, Kleffner, Ilka, additional, Knoflach, Michael, additional, Nedeltchev, Krassen, additional, Krause, Lars Udo, additional, Lappalainen, Kimmo, additional, Lefebvre, Margaux, additional, Leyon, Joe, additional, Liao, Liang, additional, Liegey, Jean-Sebastien, additional, Loehr, Christian, additional, Michel, Patrik, additional, Nannoni, Stefania, additional, Nicholson, Patrick, additional, Nico, Lorena, additional, Obadia, Michael, additional, Ognard, Julien, additional, Ogungbemi, Ayokunle, additional, Olivot, Jean-Marc, additional, Escalard, Simon, additional, Pasi, Marco, additional, Peeling, Lissa, additional, Perez, Jane, additional, Petersen, Martina, additional, Piechowiak, Eike, additional, Raposo, Roberto, additional, Räty, Silja, additional, Reitz, Sarah C., additional, Remollo, Sebastià, additional, Remonda, Luca, additional, Rennie, Ian, additional, Requena, Manuel, additional, Riabikin, Alexander, additional, Riva, Roberto, additional, Rouchaud, Aymeric, additional, Rosi, Andrea, additional, Rubiera, Marta, additional, Spelle, Laurent, additional, Schnieder, Marlena, additional, Schaafsma, Joanna D., additional, Schubert, Tilman, additional, Schulz, Jörg B., additional, Siddiqui, Mohammed, additional, Soize, Sébastien, additional, Sonnberger, Michael, additional, Touze, Emmanuel, additional, Triquenot, Aude, additional, Turc, Guillaume, additional, Vieira, Lucy, additional, Ben Hassen, Wagih, additional, Wagner, Judith N., additional, Wasser, Katrin, additional, Weber, Johannes, additional, Wenz, Holger, additional, Weisenburger-Lile, David, additional, Wodarg, Fritz, additional, Wolff, Valérie, additional, and Wunderlich, Silke, additional

Published
2022
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12. Aspiration Versus Stent Retriever Thrombectomy for Distal, Medium Vessel Occlusion Stroke in the Posterior Circulation: A Subanalysis of the TOPMOST Study

Author

Meyer, Lukas, Stracke, Paul, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter, Piechowiak, Eike, I, Kaesmacher, Johannes, Maegerlein, Christian, Petzsche, Moritz Roman Hernandez, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Mohlenbruch, Markus, Weyland, Charlotte S., Langner, Sonke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard, Tan, Benjamin, Gopinathan, Anil, Gory, Benjamin, Galvan-Fernandez, Jorge, Schuller, Miguel, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, Andre, Psychogios, Marios, Andersson, Tommy, Chapot, Rene, Fiehler, Jens, Hanning, Uta, Meyer, Lukas, Stracke, Paul, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter, Piechowiak, Eike, I, Kaesmacher, Johannes, Maegerlein, Christian, Petzsche, Moritz Roman Hernandez, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Mohlenbruch, Markus, Weyland, Charlotte S., Langner, Sonke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard, Tan, Benjamin, Gopinathan, Anil, Gory, Benjamin, Galvan-Fernandez, Jorge, Schuller, Miguel, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, Andre, Psychogios, Marios, Andersson, Tommy, Chapot, Rene, Fiehler, Jens, and Hanning, Uta

Abstract

Background: The optimal endovascular strategy for reperfusing distal medium-vessel occlusions (DMVO) remains unknown. This study evaluates angiographic and clinical outcomes of thrombectomy strategies in DMVO stroke of the posterior circulation. Methods: TOPMOST (Treatment for Primary Medium Vessel Occlusion Stroke) is an international, retrospective, multicenter, observational registry of patients treated for DMVO between January 2014 and June 2020. This study analyzed endovascularly treated isolated primary DMVO of the posterior cerebral artery in the P2 and P3 segment. Technical feasibility was evaluated with the first-pass effect defined as a modified Thrombolysis in Cerebral Infarction Scale score of 3. Rates of early neurological improvement and functional modified Rankin Scale scores at 90 days were compared. Safety was assessed by the occurrence of symptomatic intracranial hemorrhage and intervention-related serious adverse events. Results: A total of 141 patients met the inclusion criteria and were treated endovascularly for primary isolated DMVO in the P2 (84.4%, 119) or P3 segment (15.6%, 22) of the posterior cerebral artery. The median age was 75 (IQR, 62-81), and 45.4% (64) were female. The initial reperfusion strategy was aspiration only in 29% (41) and stent retriever in 71% (100), both achieving similar first-pass effect rates of 53.7% (22) and 44% (44; P=0.297), respectively. There were no significant differences in early neurological improvement (aspiration: 64.7% versus stent retriever: 52.2%; P=0.933) and modified Rankin Scale rates (modified Rankin Scale score 0-1, aspiration: 60.5% versus stent retriever 68.6%; P=0.4). In multivariable logistic regression analysis, the time from groin puncture to recanalization was associated with the first-pass effect (adjusted odds ratio, 0.97 [95% CI, 0.95-0.99]; P<0.001) that in turn was associated with early neurological improvement (aOR, 3.27 [95% CI, 1.16-9.21]; P<0.025). Symptomatic intracranial hemorrh

Published
2022

13. Outcome After Thrombectomy and Intravenous Thrombolysis in Patients With Acute Ischemic Stroke: A Prospective Observational Study

Author

Minnerup, Jens, Wersching, Heike, Teuber, Anja, Wellmann, Jürgen, Eyding, Jens, Weber, Ralph, Reimann, Gernot, Weber, Werner, Krause, Lars Udo, Kurth, Tobias, Berger, Klaus, Homberg, V., Petrovitch, A., Heuser, L., Mönnigs, P., Krogias, C., Wallner, B., Hennigs, S., Ahlers, A., Sahl, H., Ranft, A., Dobis, C., Brassel, F., Nolden-Koch, M., Schmitt, H., Chapot, R., Nordmeyer, H., Schlamann, M., Weimar, C., Busch, F., Busch, E.W., Sigges, E., Ruf, H., Wohlfahrt, K., Karatschai, R., Klein, B., Höhle, T., Haass, A., Nasreldein, A., Büchele, B., Gahn, G., Sterker, M., Hantel, T., Krämer, C., Henningsen, H., Adelt, I., König, M., Schmidt, C., Hofmann, A., Niederstadt, T., Unrath, M., Rehfeldt, T., Fauser, B., Pfeiffer, A., Lowens, S., Stögbauer, F., Staudacher, T., Erdmann, P., Grotemeyer, K.H., Spüntrup, E., Bücke, P., Wienecke, P., Faiss, J., Wolzik-Großmann, M., Brune, N., Isenmann, S., Thomas, C., and Mucha, D.

Published
2016
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14. Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke

Author

Meyer, Lukas, Stracke, Christian Paul, Jungi, Noël, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter, Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Möhlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Sönke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard, Tan, Benjamin Yong-Qiang, Anil, Gopinathan, Gory, Benjamin, Galván, Jorge, Arteaga, Miguel Schüller, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenák, Kamil, Martinez-Galdamez, Mario, Fischer, Urs, Kastrup, Andreas, Roth, Christian, Papanagiotou, Panagiotis, Kemmling, André, Gralla, Jan, Psychogios, Marios-Nikos, Andersson, Tommy, Chapot, Rene, Fiehler, Jens, Kaesmacher, Johannes, Hanning, Uta, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Bern University Hospital [Berne] (Inselspital), Alfried Krupp Krankenhaus [Essen], University Hospital Basel [Basel], Klinikums rechts der Isar, University-Hospital Munich-Großhadern [München], University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein (UKSH), Kiel University, Universitätsklinikum Köln (Uniklinik Köln), University Medical Center Göttingen (UMG), Universitätsklinikum Knappschaftskrankenhaus [Bochum], Heidelberg University Hospital [Heidelberg], University Medical Center Rostock, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], National University Health System [Singapore] (NUHS), Yong Loo Lin School of Medicine [Singapore], Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Hospital Clinico Universitario de Valladolid [Castilla y León, Spain] (HCUV), Hospital Universitario La Paz, New York University Langone Medical Center (NYU Langone Medical Center), NYU System (NYU), Karolinska University Hospital [Stockholm], Jessenius Medical Faculty [Commenius University, Slovaquie] (JFMED), Commenius University in Bratislava - Univerzita Komenského, Klinikum Bremen-Mitte, National and Kapodistrian University of Athens (NKUA), and Karolinska Institutet [Stockholm]

Subjects
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2021
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15. Thrombectomy for secondary distal, medium vessel occlusions of the posterior circulation: seeking complete reperfusion

Author

Meyer, Lukas, primary, Stracke, Christian Paul, additional, Wallocha, Marta, additional, Broocks, Gabriel, additional, Sporns, Peter B, additional, Piechowiak, Eike I, additional, Kaesmacher, Johannes, additional, Maegerlein, Christian, additional, Dorn, Franziska, additional, Zimmermann, Hanna, additional, Naziri, Weis, additional, Abdullayev, Nuran, additional, Kabbasch, Christoph, additional, Behme, Daniel, additional, Jamous, Ala, additional, Maus, Volker, additional, Fischer, Sebastian, additional, Möhlenbruch, Markus, additional, Weyland, Charlotte Sabine, additional, Langner, Soenke, additional, Meila, Dan, additional, Miszczuk, Milena, additional, Siebert, Eberhard, additional, Lowens, Stephan, additional, Krause, Lars Udo, additional, Yeo, Leonard LL, additional, Tan, Benjamin YQ, additional, Gopinathan, Anil, additional, Gory, Benjamin, additional, Arenillas, Juan F, additional, Navia, Pedro, additional, Raz, Eytan, additional, Shapiro, Maksim, additional, Arnberg, Fabian, additional, Zeleňák, Kamil, additional, Martínez-Galdámez, Mario, additional, Kastrup, Andreas, additional, Papanagiotou, Panagiotis, additional, Kemmling, Andre, additional, Psychogios, Marios N, additional, Andersson, Tommy, additional, Chapot, René, additional, Fiehler, Jens, additional, and Hanning, Uta, additional

Published
2021
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16. Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke The TOPMOST Study

Author

Meyer, Lukas, Stracke, Christian Paul, Jungi, Noel, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter B., Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Moehlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Soenke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard L. L., Tan, Benjamin Yong-Qiang, Anil, Gopinathan, Gory, Benjamin, Galvan, Jorge, Arteaga, Miguel Schueller, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Fischer, Urs, Kastrup, Andreas, Roth, Christian, Papanagiotou, Panagiotis, Kemmling, Andre, Gralla, Jan, Psychogios, Marios-Nikos, Andersson, Tommy, Chapot, Rene, Fiehler, Jens, Kaesmacher, Johannes, Hanning, Uta, Meyer, Lukas, Stracke, Christian Paul, Jungi, Noel, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter B., Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Moehlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Soenke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard L. L., Tan, Benjamin Yong-Qiang, Anil, Gopinathan, Gory, Benjamin, Galvan, Jorge, Arteaga, Miguel Schueller, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Fischer, Urs, Kastrup, Andreas, Roth, Christian, Papanagiotou, Panagiotis, Kemmling, Andre, Gralla, Jan, Psychogios, Marios-Nikos, Andersson, Tommy, Chapot, Rene, Fiehler, Jens, Kaesmacher, Johannes, and Hanning, Uta

Abstract

This case-control study analyzes the clinical, functional, and safety outcomes associated with endovascular therapy for patients with posterior circulation distal, medium vessel occlusion. Question Is mechanical thrombectomy for ischemic stroke attributed to primary distal occlusion of the posterior cerebral artery of the P2 or P3 segment safe, technically feasible, and associated with clinical benefits compared with standard medical treatment alone? Findings In this case-control study of 184 patients, endovascular treatment appeared to be safe (symptomatic intracerebral hemorrhage) and technically feasible (proportion of successful recanalization) and showed early clinical treatment benefits on the National Institutes of Health Stroke Scale, compared with standard medical treatment alone. Meaning Results of this study suggest that, among patients who experienced stroke attributed to primary distal occlusion of the posterior cerebral artery of the P2 or P3 segment, mechanical thrombectomy is a reasonable, safe and technically feasible therapy option. Importance Clinical evidence of the potential treatment benefit of mechanical thrombectomy for posterior circulation distal, medium vessel occlusion (DMVO) is sparse. Objective To investigate the frequency as well as the clinical and safety outcomes of mechanical thrombectomy for isolated posterior circulation DMVO stroke and to compare them with the outcomes of standard medical treatment with or without intravenous thrombolysis (IVT) in daily clinical practice. Design, Setting, and Participants This multicenter case-control study analyzed patients who were treated for primary distal occlusion of the posterior cerebral artery (PCA) of the P2 or P3 segment. These patients received mechanical thrombectomy or standard medical treatment (with or without IVT) at 1 of 23 comprehensive stroke centers in Europe, the United States, and Asia between January 1, 2010, and June 30, 2020. All patients who met the inclusion criteria w

Published
2021

17. Emergency Intracranial Stenting in Acute Stroke: Predictors for Poor Outcome and for Complications

Author

Stracke, Christian Paul, primary, Fiehler, Jens, additional, Meyer, Lukas, additional, Thomalla, Götz, additional, Krause, Lars Udo, additional, Lowens, Stephan, additional, Rothaupt, Jan, additional, Kim, Byung Moon, additional, Heo, Ji Hoe, additional, Yeo, Leonard L.L., additional, Andersson, Tommy, additional, Kabbasch, Christoph, additional, Dorn, Franziska, additional, Chapot, Rene, additional, and Hanning, Uta, additional

Published
2020
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19. Intracranial Stenting After Failed Thrombectomy in Patients With Moderately Severe Stroke: A Multicenter Cohort Study

Author

Meyer, Lukas, Fiehler, Jens, Thomalla, Goetz, Krause, Lars Udo, Lowens, Stephan, Rothaupt, Jan, Kim, Byung Moon, Heo, Ji Hoe, Yeo, Leonard, Andersson, Tommy, Kabbasch, Christoph, Dorn, Franziska, Chapot, Rene, Stracke, Christian Paul, Hanning, Uta, Meyer, Lukas, Fiehler, Jens, Thomalla, Goetz, Krause, Lars Udo, Lowens, Stephan, Rothaupt, Jan, Kim, Byung Moon, Heo, Ji Hoe, Yeo, Leonard, Andersson, Tommy, Kabbasch, Christoph, Dorn, Franziska, Chapot, Rene, Stracke, Christian Paul, and Hanning, Uta

Abstract

Background and Purpose: Recently, acute intracranial stenting (ICS) has gained more interest as a potential bailout strategy for large vessel occlusions (LVO) that are refractory to thrombectomy. However, there are currently no reports on ICS in patients with moderately severe stroke discussing the question if implementing a permanent stent is feasible and leads to improved recanalization after failed thrombectomy. Methods: We analyzed a large multicenter database of patients receiving ICS for anterior circulation LVO after failed thrombectomy. Inclusion criteria were defined as: Moderately severe stroke (National Institute Health Stroke Scale (NIHSS) <= 9 on admission), anterior circulation LVO, acute ICS after failed stent retriever MT. Primary endpoint was the rate of improved successful recanalization after ICS defined as a modified Thrombolysis In cerebral Infarction (mTICI) score >= 2b. Favorable neurological outcome was defined as an early neurological improvement (ENI) of 4 points or reaching 0 with respect to baseline NIHSS. Results: Forty-one patients met the inclusion criteria. A median of 2 retrievals were performed (IQR 1-4) prior decision-making for ICS. ICS led in 90.2% (37/41) of cases to a final mTICI >= 2b with significant improvement (p < 0.001) after the last retrieval attempt. The median NIHSS decreased (p = 0.178) from 7 (IQR 3.5-8) on admission to 2.5 (IQR 0-8.25) at discharge. ENI was observed in 47.4% (18/38). sICH occurred in 4.8% (2/41). Conclusion: ICS after failed thrombectomy appears to effectively improve recanalization rates in patients with moderately severe strokes. Thus, ICS should be considered also for patients with baseline NIHSS <= 9 if thrombectomy fails.

Published
2020

20. Emergency Intracranial Stenting in Acute Stroke: Predictors for Poor Outcome and for Complications

Author

Stracke, Christian Paul, Fiehler, Jens, Meyer, Lukas, Thomalla, Goetz, Krause, Lars Udo, Lowens, Stephan, Rothaupt, Jan, Kim, Byung Moon, Heo, Ji Hoe, Yeo, Leonard L. L., Andersson, Tommy, Kabbasch, Christoph, Dorn, Franziska, Chapot, Rene, Hanning, Uta, Stracke, Christian Paul, Fiehler, Jens, Meyer, Lukas, Thomalla, Goetz, Krause, Lars Udo, Lowens, Stephan, Rothaupt, Jan, Kim, Byung Moon, Heo, Ji Hoe, Yeo, Leonard L. L., Andersson, Tommy, Kabbasch, Christoph, Dorn, Franziska, Chapot, Rene, and Hanning, Uta

Abstract

Background Stent-retriever thrombectomy is the first-line therapy in acute stroke with intracranial large vessel occlusion. In case of failure of stent-retriever thrombectomy, rescue stent angioplasty might be the only treatment option to achieve permanent recanalization. This study aims at identifying predictors for poor outcome and complications in a large, multicenter cohort receiving rescue stent angioplasty. Methods and Results We performed a retrospective analysis of patients with large vessel occlusion who were treated with rescue stent angioplasty after stent-retriever thrombectomy between 2012 and 2018 in 7 neurovascular centers. We defined 2 binary outcomes: (1) functional clinical outcome (good modified Rankin Scale, 0-2; and poor modified Rankin Scale, 4-6) and (2) early symptomatic intracerebral hemorrhage. Impacts of clinical, radiological, and interventional parameters on outcomewere assessed in uni- and multivariable logistic regression models. Two hundred ten patients were included with target vessels located within the anterior circulation (136 of 210; 64.8%) and posterior circulation (74 of 210; 35.2%). Symptomatic intracerebral hemorrhage occured in 22 patients, 86.4% (19 of 22) after anterior and 13.6% (3 of 22) after posterior circulation large vessel occlusion. Good functional outcome was observed in 44.8% (73 of 163). A higher National Institutes of Health Stroke Scale on admission (adjusted odds ratio, 1.10; P=0.002), a higher premorbid modified Rankin Scale (adjusted odds ratio, 2.02; P=0.049), and a modified Thrombolysis in Cerebral Infarction score of 0 to 2a after stenting (adjusted odds ratio, 23.24; P<0.001) were independent predictors of poor functional outcome. Conclusions Use of rescue stent angioplasty can be considered for acute intracranial large vessel occlusion in cases after unsuccessful stent-retriever thrombectomy. Likelihood of symptomatic intracerebral hemorrhage is higher in anterior circulation stroke.

Published
2020

21. Intracranial Stenting After Failed Thrombectomy in Patients With Moderately Severe Stroke: A Multicenter Cohort Study

Author

Meyer, Lukas, primary, Fiehler, Jens, additional, Thomalla, Götz, additional, Krause, Lars Udo, additional, Lowens, Stephan, additional, Rothaupt, Jan, additional, Kim, Byung Moon, additional, Heo, Ji Hoe, additional, Yeo, Leonard, additional, Andersson, Tommy, additional, Kabbasch, Christoph, additional, Dorn, Franziska, additional, Chapot, René, additional, Stracke, Christian Paul, additional, and Hanning, Uta, additional

Published
2020
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22. Intracranial bailout stenting with the Acclino (Flex) Stent/NeuroSpeed Balloon Catheter after failed thrombectomy in acute ischemic stroke: a multicenter experience

Author

Stracke, Christian Paul, primary, Meyer, Lukas, additional, Fiehler, Jens, additional, Leischner, Hannes, additional, Bester, Maxim, additional, Buhk, Jan Hendrik, additional, Thomalla, Goetz, additional, Krause, Lars Udo, additional, Lowens, Stephan, additional, Rothaupt, Jan, additional, Chapot, René, additional, and Hanning, Uta, additional

Published
2019
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23. Thrombectomy for secondary distal, medium vessel occlusions of the posterior circulation: seeking complete reperfusion

Author

Meyer, Lukas, Stracke, Christian Paul, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter B, Piechowiak, Eike I, Kaesmacher, Johannes, Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Mo¨hlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Soenke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard LL, Tan, Benjamin YQ, Gopinathan, Anil, Gory, Benjamin, Arenillas, Juan F, Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zeleňák, Kamil, Martínez-Galdámez, Mario, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, Andre, Psychogios, Marios N, Andersson, Tommy, Chapot, René, Fiehler, Jens, and Hanning, Uta

Abstract

BackgroundWhether to approach distal occlusions endovascularly or not in medium-sized vessels secondary to proximal large vessel occlusion stroke remains unanswered.ObjectiveTo investigates the technical feasibility and safety of thrombectomy for secondary posterior circulation distal, medium vessel occlusions (DMVO).MethodsTOPMOST (Treatment fOr Primary Medium vessel Occlusion STroke) is an international, retrospective, multicenter, observational registry of patients treated for distal cerebral artery occlusions. This study subanalysis endovascularly treated occlusions of the posterior cerebral artery in the P2 and P3 segment secondary preprocedural or periprocedural thrombus migration between January 2014 and June 2020. Technical feasibility was evaluated with the modified Thrombolysis in Cerebral Infarction (mTICI) scale. Procedural safety was assessed by the occurrence of symptomatic intracranial hemorrhage (sICH) and intervention-related serious adverse events.ResultsAmong 71 patients with secondary posterior circulation DMVO who met the inclusion criteria, occlusions were present in 80.3% (57/71) located in the P2 segment and in 19.7% (14/71) in the P3 segment. Periprocedural migration occurred in 54.9% (39/71) and preprocedural migration in 45.1% (32/71) of cases. The first reperfusion attempt led in 38% (27/71) of all cases to mTICI 3. On multivariable logistic regression analysis, increased numbers of reperfusion attempts (adjusted odds ratio (aOR)=0.39, 95% CI 0.29 to 0.88, p=0.009) and preprocedural migration (aOR=4.70, 95% CI,1.35 to 16.35, p=0.015) were significantly associated with mTICI 3. sICH occurred in 2.8% (2/71).ConclusionThrombectomy for secondary posterior circulation DMVO seems to be safe and technically feasible. Even though thrombi that have migrated preprocedurally may be easier to retract, successful reperfusion can be achieved in the majority of patients with secondary DMVO of the P2 and P3 segment.

Published
2022
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24. Interlaboratory variability of Ki67 staining in breast cancer

Author

Focke, Cornelia M., Bürger, Horst, van Diest, Paul J., Finsterbusch, Kai, Gläser, Doreen, Korsching, Eberhard, Decker, Thomas, Anders, M., Bollmann, R., Eiting, Fr, Friedrich, K., Habeck, J. O., Haroske, G., Hinrichs, B., Behrens, A., Krause, Lars Udo, Braun-Lang, U., Lorenzen, J., Minew, N., Mlynek-Kersjes, M., Nenning, H., Packeisen, J., Poche-de Vos, F., Reyher-Klein, S., Rothacker, D., Schultz, M., Sturm, U., Tawfik, M., Berghäuser, K. H., Böcker, W, Cserni, G., Habedank, S., Lax, S., Moinfar, F., Regitnig, P., Reiner-Concin, A., Rüschoff, J., Varga, Z., Woziwodski, J., and German Breast Screening Pathology Initiative

Subjects
Subtyping, Cancer Research, Breast cancer, St Gallen consensus, Oncology, Proliferation, Journal Article, Variability, Immunohistochemistry, Ki67
Abstract

Background Postanalytic issues of Ki67 assessment in breast cancers like counting method standardisation and interrater bias have been subject of various studies, but little is known about analytic variability of Ki67 staining between pathology labs. Our aim was to study interlaboratory variability of Ki67 staining in breast cancer using tissue microarrays (TMAs) and central assessment to minimise preanalytic and postanalytic influences. Methods Thirty European pathology labs stained serial slides of a TMA set of breast cancer tissues with Ki67 according to their routine in-house protocol. The Ki67-labelling index (Ki67-LI) of 70 matched samples was centrally assessed by one observer who counted all cancer cells per sample. We then tested for differences between the labs in Ki67-LI medians by analysing variance on ranks and in proportions of tumours classified as luminal A after dichotomising oestrogen receptor–positive cancers into cancers showing low (

Published
2017

25. The Changing Landscape for Stroke Prevention in AF Findings From the GLORIA-AF Registry Phase 2

Author

Huisman, Menno V., Rothman, Kenneth J., Paquette, Miney, Teutsch, Christine, Diener, Hans-Christoph, Dubner, Sergio J., Halperin, Jonathan L., Chang Sheng, Ma, Zint, Kristina, Elsaesser, Amelie, Bartels, Dorothee B., Lip, Gregory Y. H., Abban, Dzifa, Abdul, Nasser, Abelson, Mark, Ackermann, Alan, Adams, Fran, Adams, Luthando, Adragão, Pedro, Ageno, Walter, Aggarwal, Rajesh, Agosti, Sergio, Marin, Javier Aguila, Aguilar, Francisco, Aguilar Linares, Julio Alberto, Aguinaga, Luis, Ahmad, Zia, Ainsworth, Paul, Al Ghalayini, Kamal, Al Ismail, Saad, Alasfar, Abdelfatah, Alawwa, Abdul, Al-Dallow, Raed, Alderson, Lisa, Alexopoulos, Dimitrios, Ali, Abdullah, Ali, Malik, Aliyar, Pareed, Al-Joundi, Tammam, Al Mahameed, Soufian, Almassi, Hossein, Almuti, Khalid, Al-Obaidi, Mohamed, Alshehri, Mohamed, Altmann, Ute, Alves, Alvaro Rabelo, Al-Zoebi, Ayham, Amara, Walid, Amelot, Mathieu, Amjadi, Nima, Ammirati, Fabrizio, Andrawis, Nabil, Angoulvant, Denis, Annoni, Giorgio, Ansalone, Gerardo, Antonescu, Sorin Alexandru, Ariani, Mehrdad, Arias, Juan Carlos, Armero, Sébastien, Arora, Rohit, Arora, Chander, Ashcraft, William, Aslam, M. Shakil, Astesiano, Alfredo, Audouin, Philippe, Augenbraun, Charles, Aydin, S., Azar, Rabih, Azim, Abul, Aziz, Shahid, Backes, Luciano Marcelo, Baig, Mirza, Bains, Suchdeep, Bakbak, Asaad, Baker, Seth, Bakhtiar, Karim, Bala, Richard, Banayan, Jonathan, Bandh, Stellan, Bando, Shigenobu, Banerjee, Subhash, Bank, Alan, Barbarash, Olga, Barón, Gonzalo, Barr, Craig, Barrera, Carlos, Barton, John, Kes, Vanja Basic, Baula, Giovanni, Bayeh, Hamid, Bazargani, Nooshin, Behrens, Steffen, Bell, Alan, Benezet-Mazuecos, Juan, Benhalima, Bouziane, Berdagué, Philippe, Berg van den, B. J., Bergen van, P. F. M. M., Berngard, Edvard, Bernstein, Richard, Berrospi, Percy, Berti, Sergio, Bertomeu, Vicente, Berz, Andrea, Bettencourt, Paulo, Betzu, Robert, Beyer-Westendorf, Jan, Bhagwat, Ravi, Black, Toby, Blanco Ibaceta, Jorge Hugo, Bloom, Stephen, Blumberg, Edwin, Mario, Bo, Bockisch, Valerie, Bøhmer, Ellen, Bongiorni, Maria Grazia, Boriani, Giuseppe, Bosch, Ralph, Boswijk, D. J., Bott, Jochen, Bottacchi, Edo, Kalan, Marica Bracic, Brandes, Axel, Bratland, Bjørn, Brautigam, Donald, Breton, Nicolas, Brouwers, P. J. A. M., Browne, Kevin, Bruguera, Jordi, Brunehaut, Myriam, Brunschwig, Claude, Buathier, Hervé, Buhl, Aurélie, Bullinga, John, Butcher, Kenneth, Cabrera Honorio, Jose Walter, Caccavo, Alberto, Cadinot, Didier, Cai, Shanglang, Calvi, Valeria, Camm, John, Candeias, Rui, Capo, James, Capucci, Alessandro, Cardoso, Juliano Novaes, Duarte Vera, Yan Carlos, Carlson, Brian, Carvalho, Paula, Cary, Susanna, Casanova, Rene, Casu, Gavino, Cattan, Simon, Cavallini, Claudio, Cayla, Guillaume, Cha, Tae Joon, Cha, Kwang Soo, Chaaban, Said, Chae, Jei Keon, Challappa, Krishnan, Chand, Sunil, Chandrashekar, Harinath, Chang, Mark, Charbel, Paul, Chartier, Ludovic, Chatterjee, Kausik, Cheema, Aamir, Chen, Shih-Ann, Chevallereau, Pierre, Chiang, Fu-Tien, Chiarella, Francesco, Chih-Chan, Lin, Cho, Yong Keun, Choi, Dong Ju, Chouinard, Guy, Danny, Null, Chow, Hoi Fan, Chrysos, Dimitrios, Chumakova, Galina, José Roberto Chuquiure Valenzuela, Eduardo Julián, Cieza-Lara, Tomas, Nica, Violeta Cindea, Ciobotaru, Vlad, Cislowski, David, Citerne, Olivier, Claus, Matthias, Clay, Anthony, Clifford, Piers, Cohen, Serge, Cohen, Andrew, Colivicchi, Furio, Collins, Rónán, Compton, Steve, Connors, Sean, Conti, Alberto, Buenostro, Gabriel Contreras, Coodley, Gregg, Cooper, Martin, Corbett, Lynn, Corey, Oran, Coronel, Julián, Corrigan, John, Cotrina Pereyra, Rosa Ysabel, Cottin, Yves, Coutu, Benoit, Cracan, Aurel, Crean, Peter, Crenshaw, James, Crijns, H. J. G. M., Crump, Charles, Cucher, Fred, Cudmore, David, Cui, Lianqun, Culp, John, Darius, Harald, Dary, Patrick, Dascotte, Olivier, Dauber, Ira, Davee, Thomas, Davies, Ruth, Davis, Gershan, Davy, Jean-Marc, Dayer, Mark, De La Briolle, Axel, de Mora, Manuel, De Teresa, Eduardo, De Wolf, Luc, Decoulx, Eric, Deepak, Sasalu, Defaye, Pascal, Del-Carpio Munoz, Freddy, Brkljacic, Diana Delic, Deluche, Laurent, Destrac, Sylvain, Deumite, N. Joseph, Di Legge, Silvia, Dibon, Olivier, Diemberger, Igor, Dillinger, Jean, Dionísio, Pedro, Naydenov, Stefan, Dotani, Imran, Dotcheva, Elena, D'Souza, Anthony, Dubrey, Simon, Ducrocq, Xavier, Dupljakov, Dmitry, Duthinh, Vuong, Dutra, Oscar Pereira, Dutta, Dipankar, Duvilla, Nathalie, Johnny, Dy, Dziewas, Rainer, Eaton, Charles, Eaves, William, Ebinger, Matthew, Eck van, J. W. M., Edwards, Tim, Egocheaga, Isabel, Ehrlich, Clifford, Eisenberg, Steven, El Hallak, Abdel, El Jabali, Adnan, El Mahmoud, Rami, El Shahawy, Mahfouz, Eldadah, Zayd, Elghelbazouri, Fouad, Elhag, Omar, El-Hamdani, Mehiar, Elias, Darlene, Ellery, Adam, El-Sayed, Hassan, Elvan, A., Erickson, Bernard, Espaliat, Eric, Essandoh, Louis, Everington, Tamara, Evonich, Rudolph, Ezhov, Andrey, Fácila, Lorenzo, Farsad, Ramin, Fayard, Maxime, Fedele, Francesco, Gomes Ferreira, Luis Gustavo, Ferreira, Daniel, Santos, José Ferreira, Ferrier, Anna, Finsen, Alexandra, First, Brian, Fisher, Raymond, Floyd, John, Folk, Thomas, Fonseca, Catarina, Fonseca, Luisa, Forman, Steven, Forsgren, Magnus, Foster, Malcolm, Foster, Nathan, Frais, Michael, Frandsen, Brad, Frappé, Thierry, Freixa, Ramon, French, William, Freydlin, Marina, Frickel, Siegfried, Fruntelata, Ana Gabriela, Fujii, Shigeru, Fujino, Yusuke, Fukunaga, Hiroshi, Furukawa, Yutaka, Gabelmann, Matthias, Gabris, Michael, Gadsbøll, Niels, Galin, Pavel, Galinier, Michel, Ganim, Ricky, Garcia, Ronnie, Quintana, Antonio Garcia, Gartenlaub, Olivier, Genz, Conrad, Georger, Frédéric, Georges, Jean-Louis, Georgeson, Steven, Ghanbasha, Ali, Giedrimas, Evaldas, Gierba, Mariusz, Gillespie, Eve, Giniger, Alberto, Gkotsis, Alexandros, Gmehling, Joachim, Gniot, Jacek, Goethals, Peter, Goldberg, Ronald, Goldmann, Britta, Goldscher, David, Golitsyn, Sergey, Gomez Lopez, Efrain Alonso, Gomez Mesa, Juan Esteban, Gonzalez, Efrain, Cocina, Emilio Gonzalez, Juanatey, Carlos Gonzalez, Gorbunov, Vladimir, Gordon, Brian, Gorka, Hervé, Gornick, Charles, Gorog, Diana, Goss, Franz, Götte, Andreas, Goube, Pascal, Goudevenos, Ioannis, Goulden, Dudley, Graham, Brett, Grande, Angel, Greco, Cesare, Green, Martin, Greer, Gerald, Gremmler, Uwe, Grena, Paul, Grinshstein, Yuriy, Grond, Martin, Gronda, Edoardo, Grondin, Francois, Grönefeld, Gerian, Groot de, J. R., Guardigli, Gabriele, Guarnieri, Thomas, Caiedo, Carolina Guevara, Guignier, Alexandre, Gulizia, Michele, Gumbley, Michael, Gupta, Dhiraj, Hack, Terrence, Haerer, Winfried, Hakas, Joseph, Hall, Christian, Hampsey, James, Hananis, Georgios, Hanbali, Basel, Handel, Franklin, Hargrove, Joe, Hargroves, David, Harris, Kenneth, Hartley, David, Haruna, Tetsuya, Hata, Yoshiki, Hayek, Emil, Healey, Jeff, Hearne, Steven, Heggelund, Geir, Hemels, M. E. W., Hemery, Yann, Henein, Sam, Henz, Benhur, Her, Sung-Ho, Hermany, Paul, Hernandes, Mauro Esteves, Higashino, Yorihiko, Hill, Michael, Hisadome, Tetsuo, Hishida, Eiji, Hitchcock, James, Hoffer, Etienne, Hoghton, Matthew, Holmes, Clare, Hong, Suk Keun, Houppe Nousse, Marie-Paule, Howard, Victor, Hsu, Li Fern, Huang, Chi-Hung, Huckins, David, Huehnergarth, Kier, Huizenga, A., Huntley, Richard, Hussein, Gamal, Hwang, Gyo-Seung, Igbokidi, Oyidie, Iglesias, Ignacio, Ikpoh, Margaret, Imberti, Davide, Ince, Hüseyin, Indolfi, Ciro, Ionova, Tatiana, John, Ip, Irles, Didier, Iseki, Harukazu, Ismail, Younus, Israel, Noah, Isserman, Steven, Iteld, Bruce, Ivanchura, Galina, Iyer, Ramakrishnan, Iyer, Venkat, Iza Villanueva, Ruben Omar, Jackson-Voyzey, Ewart, Jaffrani, Naseem, Jäger, Frank, Jain, Manish, James, Martin, Jamon, Yann, Jang, Sung Won, Pereira Jardim, Cesar Augusto, Jarmukli, Nabil, Jeanfreau, Robert, Jenkins, Ronald, Jiang, Xianyan, Jiang, Heng, Jiang, Tiemin, Jiang, Nan, Jimenez, Javier, Jobe, Robert, Joffe, Ian, Johansson, Bengt, Jones, Nick, Moura Jorge, Jose Carlos, Jouve, Bernard, Jundi, Mayar, Jung, Werner, Jung, Byung Chun, Jung, Kyung Tae, Kabbani, Samer, Kabour, Ameer, Kafkala, Chrystalenia, Kajiwara, Koji, Kalinina, Larisa, Kampus, Priit, Kanda, Junji, Kapadia, Shaival, Karim, Amin, Karolyi, Laszlo, Kashou, Hisham, Kastrup, Andreas, Katsivas, Apostolos, Kaufman, Elizabeth, Kawai, Kazuya, Kawajiri, Kenji, Kazmierski, John, Keeling, Phil, Kerfes, Galal Ali, Kerr Saraiva, José Francisco, Ketova, Galina, Khaira, Ajit, Khalid, Muhammad, Khludeeva, Elena, Khripun, Aleksey, Kim, Doo Il, Kim, Dae Kyeong, Kim, Nam Ho, Kim, Ki Seok, Kim, Young-Hoon, Kim, Jin bae, Kim, June Soo, Kim, Jeong Su, Kinova, Elena, Klein, Alexander, Kleinschnitz, Christoph, Kmetzo, James, Kneller, G. Larsen, Knezevic, Aleksandar, Koch, Stanley, Koenig, Kai, Angela Koh, Su Mei, Köhrmann, Martin, Koons, Jay, Korabathina, Ravikiran, Korennova, Olga, Koschutnik, Martin, Kosinski, Edward, Kovacic, Dragan, Kowalczyk, Jacek, Koziolova, Natalya, Kragten, J. A., Krause, Lars Udo, Kreidieh, Imad, Krenning, B. J., Krishnaswamy, Kannappan, Krysiak, Waldemar, Kuck, Karl-Heinz, Kumar, Somnath, Kümler, Thomas, Kuniss, Malte, Kuo, Jen-Yuan, Küppers, Achim, Kurrelmeyer, Karla, Kwan, Tak, Kyo, Eisho, Labovitz, Arthur, Lacroix, Alain, Lam, Andy, Lanas Zanetti, Fernando Tomas, Landau, Charles, Landini, Giancarlo, Lang, Wilfried, Larsen, Torben Bjerregaard, Laske, Volker, Lavandier, Karine, Law, Nicki, Lee, Moon Hyoung, Lee, Daniel, Leitão, Ana, Lejay, Dominique, Lelonek, Malgorzata, Lenarczyk, Radoslaw, Leprince, Patrick, Lequeux, Benoit, Leschke, Matthias, Ley, Nicolas, Zicheng, Li, Yansheng, Li, Xiaodong, Li, Zhanquan, Li, Weihua, Li, Liang, Jianqiu, Lieber, Ira, Lillestol, Michael, Limon Rodriguez, Ramon Horacio, Lin, Hailong, Lip, Gregory, Litchfield, Jennifer, Liu, Zhitao, Liu, Xuebo, Liu, Yalin, Liu, Feng, Liu, Wenhui, Llamas Esperon, Guillermo Antonio, Llisterri, Jose Luis, Ted, Lo, Eric, Lo, Lobos, Jose Maria, Lodde, Bernhard-Paul, Loiselet, Philippe, López-Sendón, José, Lorga Filho, Adalberto Menezes, Lori, Ido, Luo, Ming, Lupovitch, Steven, Lyrer, Philippe, Zuhairy, Hamed M., Changsheng, Ma, Genshan, Ma, Hong, Ma, Madariaga, Irene, Maeno, Koji, Magnin, Dominique, Mahmood, Shahid, Mahood, Karen, Maid, Gustavo, Mainigi, Sumeet, Makaritsis, Konstantinos, Maldonado Villalon, José Arturo, Malhotra, Rohit, Malik, Amir, Mallecourt, Catherine, Mallik, Rajiv, Manning, Rickey, Manolis, Athanasios, Mantas, Ioannis, Manzur Jattin, Fernando Gabriel, Marcionni, Niccolo', Marín, Francisco, Santana, Antonio Martín, Martinez, Jorge, Martinez, Luis, Maskova, Petra, Hernández, Norberto Matadamas, Matskeplishvili, Simon, Matsuda, Katsuhiro, Mavri, Alenka, May, Erik, Mayer, Nolan, Mazon, Pilar, Mcclure, John, Mccormack, Terry, Mcgarity, William, Mcguire, Michael, Mcintyre, Hugh, Mclaughlin, Paul, Mclaurin, Brent, Medina Palomino, Feliz Alvaro, Mehta, Paresh, Mehzad, Reza, Meinel, Andreas, Melandri, Francesco, Mena, Amparo, Meno, Hirosi, Menzies, Dhananjai, Metcalf, Kneale, Meyer, Beat, Miarka, Jacek, Mibach, Frank, Michalski, Dominik, Michel, Patrik, Chreih, Rami Mihail, Mikdadi, Ghiath, Mikhail, Magdy, Mikus, Milan, Milicic, Davor, Militaru, Constantin, Miller, Gary, Milonas, Christos, Minescu, Bogdan, Mintale, Iveta, Miralles, Aurélien, Mirault, Tristan, Mistry, Dinesh, Mitchell, George, Miu, Nicoleta Violeta, Miyamoto, Naomasa, Moccetti, Tiziano, Mohammed, Akber, Nor, Azlisham Mohd, Molina de Salazar, Dora Ines, Molon, Giulio, Molony, David, Mondillo, Sergio, Mont, Lluis, Moodley, Rajendra, Moore, Roger, Ribeiro Moreira, Dalmo Antonio, Mori, Kiyoo, Moriarty, Andrew, Morka, Jacek, Moschos, Nikitas, Mota Gomes, Marco Antônio, Mousallem, Nicolas, Moya, Angel, Mügge, Andreas, Mulhearn, Thomas, Muller, Jean-Joseph, Muresan, Carmen Manuela, Muse, Derek, Musial, Wlodzimierz, Musumeci, Francesco, Nadar, Venkatesh, Nageh, Thuraia, Nair, Priya, Nakagawa, Hidemitsu, Nakamura, Yuichiro, Nakayama, Toru, Nam, Ki-Byeong, Napalkov, Dmitry, Natarajan, Indira, Nayak, Hemal, Nechvatal, Libor, Neiman, James, Nerheim, Pamela, Neuenschwander, Fernando Carvalho, Nishida, Kunihiro, Nizov, Alexey, Novikova, Tatiana, Novo, Salvatore, Nowalany-Kozielska, Ewa, Nsah, Emmanuel, Nunez Fragoso, Juan Carlos, Nyvad, Ole, de Los Rios Ibarra, Manuel Odin, O'Donnell, Martin, O'Donnell, Philip, Dong Jin, Oh, Yong Seog, Oh, Daniel Oh, Chia Theng, O'Hara, Gilles, Oikonomou, Kostas, Olalla, Juan Jose, Olivari, Zoran, Oliver, Richard, Olympios, Christoforos, Osborne, John, Osca, Joaquin, Osman, Raed, Osunkoya, Abayomi, Padanilam, Benzy, Panchenko, Elizaveta, Pandey, A. Shekhar, Vicenzo de Paola, Angelo Amato, Paraschos, Alexander, Pardell, Herbert, Park, Hyung Wook, Park, Jong Sung, Parkash, Ratika, Parker, Ian, Parrens, Eric, Parris, Robert, Passamonti, Enrico, Patel, Jaydutt, Patel, Rajesh, Pentz, William H., Persic, Viktor, Perticone, Francesco, Peters, Patrick, Petkar, Sanjiv, Pezo, Luis Felipe, Pham, David, Cao Phai, Gérald Phan, Phlaum, Stephen, Pineau, Julien, Pineda-Velez, Armando, Pini, Riccardo, Pinter, Arnold, Pinto, Fausto, Pirelli, Salvatore, Pivac, Nediljko, Pizzini, Attilia Maria, Pocanic, Darko, Calin Podoleanu, Cristian Gheorghe, Polanczyk, Carisi Anne, Polasek, Petr, Poljakovic, Zdravka, Pollock, Stewart, Polo, Jose, Poock, James, Poppert, Holger, Porro, Yamile, Pose, Antonio, Poulain, François, Poulard, Jean-Ernst, Pouzar, Joe, Povolny, Petr, Pozzer, Domingo, Pras, Athanasios, Prasad, Neeraj, Prevot, Sébastien, Protasov, Konstantin, Prunier, Laurent, Puleo, John, Pye, Maurice, Qaddoura, Fatma, Quedillac, Jean-Michel, Raev, Dimitar, Rahimi, Sidiqullah, Raisaro, Arturo, Rama, Bhola, Ranadive, Nandkishore, Randall, Katie, Ranjith, Naresh, Raposo, Nuno, Rashid, Haroon, Raters, Christa, Rauch-Kroehnert, Ursula, Rebane, Thomas, Regner, Stefan, Renzi, Michael, Reyes Rocha, Miguel Agustin, Reza, Shabbir, Ria, Luigi, Richter, Dimitrios, Rickli, Hans, Rickner, Kyle, Rieker, Werner, Rigo, Fausto, Ripoll, Tomas, Fonteles Ritt, Luiz Eduardo, Roberts, Douglas, Pascual, Carlos Rodríguez, Briones, Ignacio Rodriguez, Reyes, Humberto Rodriguez, Roelke, Marc, Roman, Mark, Romeo, Francesco, Ronner, E., Ronziere, Thomas, Rooyer, F. A., Rosenbaum, David, Roth, Sherryn, Rozkova, Nadezda, Rubacek, Miroslav, Rubalcava, Frank, Rubanenko, Olesya, Rubin, Andrew, Borret, Mariano Ruiz, Rybak, Karin, Sabbour, Hani, Morales, Oscar Saenz, Sakai, Tetsuo, Salacata, Abraham, Salecker, Ilsbe, Salem, Adrien, Salfity, Marwan, Salguero, Rafael, Salvioni, Alessandro, Samson, Mercedes, Sanchez, Gregorio, Sandesara, Chirag, Saporito, Wladmir Faustino, Sasaoka, Taishi, Sattar, Payman, Savard, Daniel, Scala, Pierre-Jean, Scemama, Jacques, Schaupp, Thierry, Schellinger, Peter, Scherr, Carlos, Schmitz, Karl-Heinz, Schmitz, Bettina, Schmitz, Lisa, Schnitzler, Robert, Schnupp, Steffen, Schoeniger, Peter, Schön, Norbert, Schuster, Stefan, Schwimmbeck, Peter, Seamark, Clare, Seebass, Ruediger, Seidl, Karl-Heinz, Seidman, Barry, Sek, Jaroslaw, Sekaran, Lakshmanan, Seko, Yoshinori, Sepulveda Varela, Pablo Andres, Sevilla, Begoña, Shah, Vinay, Shah, Anil, Shah, Neerav, Shah, Aman, Shanes, Jeffrey, Sharareh, Ali, Sharma, Vijay Kumar, Shaw, Louise, Shimizu, Yutaka, Shimomura, Hideki, Shin, Dong Gu, Shin, Eun-Seok, Shite, Junya, Shoukfeh, Mohammad, Shoultz, Charles, Silver, Frank, Sime, Iveta, Simmers, T. A., Singal, Dinesh, Singh, Narendra, Siostrzonek, Peter, Sirajuddin, Mohiburrahman, Skeppholm, Mika, Smadja, Didier, Smith, Richard, Smith, David, Soda, Hassan, Sofley, C. Wilson, Sokal, Adam, Sotolongo, Rodolfo, de Souza, Olga Ferreira, Sparby, Jon Arne, Spinar, Jindrich, Sprigings, David, Spyropoulos, Alex, Stakos, Dimitrios, Steinberg, Alon, Steinwender, Clemens, Stergiou, Georgios, Stites, H. William, Stoikov, Anastas, Strasser, Ruth, Streb, Witold, Styliadis, Ioannis, Guohai, Su, Xi, Su, Suarez, Rafael Martin, Sudnik, Wanda, Sueyoshi, Atsushi, Sukles, Kai, Sun, Li, Suneja, Randeep, Svensson, Peter, Ziekenhuis, Antonius, Szavits-Nossan, Janko, Taggeselle, Jens, Takagi, Yuichiro, Takhar, Amrit, Tallet, Julio, Tamm, Angelika, Tanaka, Shozo, Tanaka, Katsumi, Tang, Aylmer, Tang, Sherman, Tassinari, Tiziana, Tayama, Shinji, Tayebjee, Muzahir, Tebbe, Ulrich, Teixeira, Jose, Tesloianu, Dan Nicolae, Tessier, Pascal, The, S. H. K., Thevenin, Jérome, Thomas, Harold, Timsit, Serge, Topkis, Robert, Torosoff, Mikhail, Touze, Emmanuel, Traissac, Thalie, Trendafilova, Elina, Troyan, Barry, Tsai, Wenchi Kevin, Tse, Hung Fat, Tsutsui, Hiroshi, Tsutsui, Takashi, Tuininga, Y. S., Turakhia, Minang, Turk, Samir, Turner, Wayne, Tveit, Arnljot, Twiddy, Shannon, Tytus, Richard, Ukrainski, Gerald, Valdovinos Chavez, Salvador Bruno, Van De Graaff, Eric, Vanacker, Peter, Vardas, Panagiotis, Vargas, Michael, Vassilikos, Vassilios, Vazquez, Juan, Venkataraman, Asok, Verdecchia, Paolo, Vester, Ernst Günter, Vial, Hubert, Vinereanu, Dragos, Vlastaris, Anthony, Vogel, Craig, vom Dahl, Jürgen, von Mering, Matthias, Vora, Kishor, Wakefield, Paul, Walia, Jasjit, Walter, Thomas, Wang, Mingsheng, Wang, Ningfu, Wang, Feng, Wang, Xinhua, Wang, Zulu, Wang, Kuo-Yang, Watanabe, Kouki, Wei, Jeanne, Weimar, Christian, Weinrich, Renate, Wen, Ming-Shien, Wheelan, Kevin, Wicke, Jens, Wiemer, Marcus, Wild, Beate, Wilke, Andreas, Willems, Stephan, Williams, Marcus, Williams, David, Winkler, Andreas, Wirtz, Jost Henner, Witzenbichler, Bernhard, Wong, Danny H. K., Lawrence Wong, Ka Sing, Wong, Brian, Wozakowska-Kaplon, Beata, Zhaohui, Wu, Shulin, Wu, Wyatt, Nell, Yong, Xu, Xiangdong, Xu, Yamada, Akira, Yamamoto, Kazuya, Yamanoue, Hiroki, Yamashita, Takeshi, Bryan Yan, Ping Yen, Yang, Yanmin, Yang, Tianlun, Yao, Jing, Yarlagadda, Chakri, Yeh, Kuo-Ho, Yotov, Yoto, Yvorra, Serge, Zahn, Ralf, Zamorano, José, Zanini, Roberto, Zarich, Stuart, Zebrack, James, Zenin, Sergei, Zeuthen, Elisabeth Louise, Zhang, Xingwei, Zhang, Quansan, Zhang, Dadong, Zhang, Donghui, Zhang, Huanyi, Zhao, Shuiping, Zhao, Xinwen, Zheng, Yang, Zheng, Qiangsun, Zhou, Jing, Zhou, Jian, Zimmermann, Sergio Luiz, Zimmermann, Rainer, Zukerman, L. Steven, and Zwaan van der, C.

Subjects
oral anticoagulation, cross-sectional studies, registries, antithrombins, registry, stroke, internationality, prospective studies, aged, cardiology and cardiovascular medicine, female, male, fibrinolytic agents, middle aged, dabigatran, atrial fibrillation, humans
Published
2017

26. Intracranial bailout stenting with the Acclino (Flex) Stent/NeuroSpeed Balloon Catheter after failed thrombectomy in acute ischemic stroke: a multicenter experience.

Author

Stracke, Christian Paul, Meyer, Lukas, Fiehler, Jens, Leischner, Hannes, Bester, Maxim, Buhk, Jan Hendrik, Thomalla, Goetz, Krause, Lars Udo, Lowens, Stephan, Rothaupt, Jan, Chapot, René, and Hanning, Uta

Subjects
MORTALITY risk factors, CEREBRAL hemorrhage, CATHETERIZATION, CEREBRAL ischemia, CONFIDENCE intervals, CONVALESCENCE, MEDICAL cooperation, MEDICAL records, NEUROSURGERY, PATIENT safety, RESEARCH, RISK assessment, SURGICAL stents, STROKE, THROMBOSIS, VEIN surgery, TREATMENT effectiveness, RETROSPECTIVE studies, ACUTE diseases, FUNCTIONAL assessment, ACQUISITION of data methodology, ODDS ratio, NIH Stroke Scale, DISEASE risk factors, OLD age
Abstract

Background and purpose To report on the feasibility, safety, and outcome of acute intracranial stenting (ICS) with the Acclino (Flex) Stent and NeuroSpeed Balloon Catheter in cases of failed mechanical thrombectomy (MT) for acute ischemic stroke (AIS). Methods We retrospectively reviewed the data of patients treated with acute bailout stenting after failed MT in three large neurointerventional centers using exclusively the Acclino (Flex) Stent and the NeuroSpeed Balloon Catheter. Functional outcome was assessed by the rate of major early neurological recovery (mENR) at 24 hours and at 90days with the modified Rankin Scale (mRS). Safety evaluation included symptomatic intracranial hemorrhage (sICH), mortality, and intervention-related serious adverse events (SAEs). Results 50 patients with a median age of 71 years met the inclusion criteria and 52% (26/50) of the occluded vessels were located within the anterior circulation. mENR was observed in 38.8% and 90-day favorable outcome (mRS ≤2) was 40.6% (13/32). Higher NIH Stroke Scale scores on admission were significantly associated with poor functional outcome (mRS ≥3) at 90 days (adjusted OR 1.28; 95% CI 1.07 to 1.53; p=0.007). sICH occurred in two cases of the study population. There were no intervention-related SAEs. Conclusion Intracranial bailout stenting with the Acclino (Flex) Stent and the NeuroSpeed Balloon Catheter after failed MT is a feasible and effective recanalization method for atherosclerotic stenosis-based stroke that is associated especially with low rates of sICH. [ABSTRACT FROM AUTHOR]

Published
2020
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27. Interlaboratory variability of Ki67 staining in breast cancer

Author

Pathologie mortuarium en obductie, UMC Utrecht, Pathologie, Cancer, Focke, Cornelia M., Bürger, Horst, van Diest, Paul J., Finsterbusch, Kai, Gläser, Doreen, Korsching, Eberhard, Decker, Thomas, Anders, M., Bollmann, R., Eiting, Fr, Friedrich, K., Habeck, J. O., Haroske, G., Hinrichs, B., Behrens, A., Krause, Lars Udo, Braun-Lang, U., Lorenzen, J., Minew, N., Mlynek-Kersjes, M., Nenning, H., Packeisen, J., Poche-de Vos, F., Reyher-Klein, S., Rothacker, D., Schultz, M., Sturm, U., Tawfik, M., Berghäuser, K. H., Böcker, W, Cserni, G., Habedank, S., Lax, S., Moinfar, F., Regitnig, P., Reiner-Concin, A., Rüschoff, J., Varga, Z., Woziwodski, J., German Breast Screening Pathology Initiative, Pathologie mortuarium en obductie, UMC Utrecht, Pathologie, Cancer, Focke, Cornelia M., Bürger, Horst, van Diest, Paul J., Finsterbusch, Kai, Gläser, Doreen, Korsching, Eberhard, Decker, Thomas, Anders, M., Bollmann, R., Eiting, Fr, Friedrich, K., Habeck, J. O., Haroske, G., Hinrichs, B., Behrens, A., Krause, Lars Udo, Braun-Lang, U., Lorenzen, J., Minew, N., Mlynek-Kersjes, M., Nenning, H., Packeisen, J., Poche-de Vos, F., Reyher-Klein, S., Rothacker, D., Schultz, M., Sturm, U., Tawfik, M., Berghäuser, K. H., Böcker, W, Cserni, G., Habedank, S., Lax, S., Moinfar, F., Regitnig, P., Reiner-Concin, A., Rüschoff, J., Varga, Z., Woziwodski, J., and German Breast Screening Pathology Initiative

Published
2017

28. Outcome after Thrombectomy and Intravenous Thrombolysis in Patients with Acute Ischemic Stroke: A Prospective Observational Study

Author

Projectafdeling functional imaging, MS VPG/Gynaecologie, Brain, Circulatory Health, Child Health, Minnerup, Jens, Wersching, Heike, Teuber, Anja, Wellmann, Jürgen, Eyding, Jens, Weber, Ralph, Reimann, Gernot, Weber, Werner, Krause, Lars Udo, Kurth, Tobias, Berger, Klaus, Homberg, V., Petrovitch, A., Heuser, L., Mönnigs, P., Krogias, C., Wallner, B., Hennigs, S., Ahlers, A., Sahl, H., Ranft, A., Dobis, C., Brassel, F., Nolden-Koch, M., Schmitt, H., Chapot, R., Nordmeyer, H., Schlamann, M., Weimar, C., Busch, F., Busch, E. W., Sigges, E., Ruf, H., Wohlfahrt, K., Karatschai, R., Klein, B., Höhle, T., Haass, A., Nasreldein, A., Büchele, B., Gahn, G., Sterker, M., Hantel, T., Krämer, C., Henningsen, H., Adelt, I., König, M., Schmidt, C., Hofmann, A., Niederstadt, T., Unrath, M., Rehfeldt, T., Fauser, B., Pfeiffer, A., Lowens, S., Stögbauer, F., Staudacher, T., Erdmann, P., Grotemeyer, K. H., Spüntrup, E., Bücke, P., Wienecke, P., Faiss, J., Wolzik-Großmann, M., Brune, N., Isenmann, S., Thomas, C., Mucha, D., Projectafdeling functional imaging, MS VPG/Gynaecologie, Brain, Circulatory Health, Child Health, Minnerup, Jens, Wersching, Heike, Teuber, Anja, Wellmann, Jürgen, Eyding, Jens, Weber, Ralph, Reimann, Gernot, Weber, Werner, Krause, Lars Udo, Kurth, Tobias, Berger, Klaus, Homberg, V., Petrovitch, A., Heuser, L., Mönnigs, P., Krogias, C., Wallner, B., Hennigs, S., Ahlers, A., Sahl, H., Ranft, A., Dobis, C., Brassel, F., Nolden-Koch, M., Schmitt, H., Chapot, R., Nordmeyer, H., Schlamann, M., Weimar, C., Busch, F., Busch, E. W., Sigges, E., Ruf, H., Wohlfahrt, K., Karatschai, R., Klein, B., Höhle, T., Haass, A., Nasreldein, A., Büchele, B., Gahn, G., Sterker, M., Hantel, T., Krämer, C., Henningsen, H., Adelt, I., König, M., Schmidt, C., Hofmann, A., Niederstadt, T., Unrath, M., Rehfeldt, T., Fauser, B., Pfeiffer, A., Lowens, S., Stögbauer, F., Staudacher, T., Erdmann, P., Grotemeyer, K. H., Spüntrup, E., Bücke, P., Wienecke, P., Faiss, J., Wolzik-Großmann, M., Brune, N., Isenmann, S., Thomas, C., and Mucha, D.

Published
2016

29. Thrombectomy for secondary distal, medium vessel occlusions of the posterior circulation: seeking complete reperfusion

Author

Meyer, Lukas, Stracke, Christian Paul, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter B., Piechowiak, Eike, I, Kaesmacher, Johannes, Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Moehlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Soenke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard L. L., Tan, Benjamin Y. Q., Gopinathan, Anil, Gory, Benjamin, Arenillas, Juan F., Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, Andre, Psychogios, Marios N., Andersson, Tommy, Chapot, Rene, Fiehler, Jens, Hanning, Uta, Meyer, Lukas, Stracke, Christian Paul, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter B., Piechowiak, Eike, I, Kaesmacher, Johannes, Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Moehlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Soenke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard L. L., Tan, Benjamin Y. Q., Gopinathan, Anil, Gory, Benjamin, Arenillas, Juan F., Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, Andre, Psychogios, Marios N., Andersson, Tommy, Chapot, Rene, Fiehler, Jens, and Hanning, Uta

Abstract

Background Whether to approach distal occlusions endovascularly or not in medium-sized vessels secondary to proximal large vessel occlusion stroke remains unanswered. Objective To investigates the technical feasibility and safety of thrombectomy for secondary posterior circulation distal, medium vessel occlusions (DMVO). Methods TOPMOST (Treatment fOr Primary Medium vessel Occlusion STroke) is an international, retrospective, multicenter, observational registry of patients treated for distal cerebral artery occlusions. This study subanalysis endovascularly treated occlusions of the posterior cerebral artery in the P2 and P3 segment secondary preprocedural or periprocedural thrombus migration between January 2014 and June 2020. Technical feasibility was evaluated with the modified Thrombolysis in Cerebral Infarction (mTICI) scale. Procedural safety was assessed by the occurrence of symptomatic intracranial hemorrhage (sICH) and intervention-related serious adverse events. Results Among 71 patients with secondary posterior circulation DMVO who met the inclusion criteria, occlusions were present in 80.3% (57/71) located in the P2 segment and in 19.7% (14/71) in the P3 segment. Periprocedural migration occurred in 54.9% (39/71) and preprocedural migration in 45.1% (32/71) of cases. The first reperfusion attempt led in 38% (27/71) of all cases to mTICI 3. On multivariable logistic regression analysis, increased numbers of reperfusion attempts (adjusted odds ratio (aOR)=0.39, 95% CI 0.29 to 0.88, p=0.009) and preprocedural migration (aOR=4.70, 95% CI,1.35 to 16.35, p=0.015) were significantly associated with mTICI 3. sICH occurred in 2.8% (2/71). Conclusion Thrombectomy for secondary posterior circulation DMVO seems to be safe and technically feasible. Even though thrombi that have migrated preprocedurally may be easier to retract, successful reperfusion can be achieved in the majority of patients with secondary DMVO of the P2 and P3 segment.

30. Thrombectomy for secondary distal, medium vessel occlusions of the posterior circulation: seeking complete reperfusion

Author

Meyer, Lukas, Stracke, Christian Paul, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter B., Piechowiak, Eike, I, Kaesmacher, Johannes, Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Moehlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Soenke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard L. L., Tan, Benjamin Y. Q., Gopinathan, Anil, Gory, Benjamin, Arenillas, Juan F., Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, Andre, Psychogios, Marios N., Andersson, Tommy, Chapot, Rene, Fiehler, Jens, Hanning, Uta, Meyer, Lukas, Stracke, Christian Paul, Wallocha, Marta, Broocks, Gabriel, Sporns, Peter B., Piechowiak, Eike, I, Kaesmacher, Johannes, Maegerlein, Christian, Dorn, Franziska, Zimmermann, Hanna, Naziri, Weis, Abdullayev, Nuran, Kabbasch, Christoph, Behme, Daniel, Jamous, Ala, Maus, Volker, Fischer, Sebastian, Moehlenbruch, Markus, Weyland, Charlotte Sabine, Langner, Soenke, Meila, Dan, Miszczuk, Milena, Siebert, Eberhard, Lowens, Stephan, Krause, Lars Udo, Yeo, Leonard L. L., Tan, Benjamin Y. Q., Gopinathan, Anil, Gory, Benjamin, Arenillas, Juan F., Navia, Pedro, Raz, Eytan, Shapiro, Maksim, Arnberg, Fabian, Zelenak, Kamil, Martinez-Galdamez, Mario, Kastrup, Andreas, Papanagiotou, Panagiotis, Kemmling, Andre, Psychogios, Marios N., Andersson, Tommy, Chapot, Rene, Fiehler, Jens, and Hanning, Uta

Abstract

Background Whether to approach distal occlusions endovascularly or not in medium-sized vessels secondary to proximal large vessel occlusion stroke remains unanswered. Objective To investigates the technical feasibility and safety of thrombectomy for secondary posterior circulation distal, medium vessel occlusions (DMVO). Methods TOPMOST (Treatment fOr Primary Medium vessel Occlusion STroke) is an international, retrospective, multicenter, observational registry of patients treated for distal cerebral artery occlusions. This study subanalysis endovascularly treated occlusions of the posterior cerebral artery in the P2 and P3 segment secondary preprocedural or periprocedural thrombus migration between January 2014 and June 2020. Technical feasibility was evaluated with the modified Thrombolysis in Cerebral Infarction (mTICI) scale. Procedural safety was assessed by the occurrence of symptomatic intracranial hemorrhage (sICH) and intervention-related serious adverse events. Results Among 71 patients with secondary posterior circulation DMVO who met the inclusion criteria, occlusions were present in 80.3% (57/71) located in the P2 segment and in 19.7% (14/71) in the P3 segment. Periprocedural migration occurred in 54.9% (39/71) and preprocedural migration in 45.1% (32/71) of cases. The first reperfusion attempt led in 38% (27/71) of all cases to mTICI 3. On multivariable logistic regression analysis, increased numbers of reperfusion attempts (adjusted odds ratio (aOR)=0.39, 95% CI 0.29 to 0.88, p=0.009) and preprocedural migration (aOR=4.70, 95% CI,1.35 to 16.35, p=0.015) were significantly associated with mTICI 3. sICH occurred in 2.8% (2/71). Conclusion Thrombectomy for secondary posterior circulation DMVO seems to be safe and technically feasible. Even though thrombi that have migrated preprocedurally may be easier to retract, successful reperfusion can be achieved in the majority of patients with secondary DMVO of the P2 and P3 segment.

31. Thrombectomy versus Medical Management for Isolated Anterior Cerebral Artery Stroke: An International Multicenter Registry Study.

Author

Meyer L, Stracke P, Broocks G, Elsharkawy M, Sporns P, Piechowiak EI, Kaesmacher J, Maegerlein C, Hernandez Petzsche MR, Zimmermann H, Naziri W, Abdullayev N, Kabbasch C, Diamandis E, Thormann M, Maus V, Fischer S, Möhlenbruch M, Weyland CS, Ernst M, Jamous A, Meila D, Miszczuk M, Siebert E, Lowens S, Krause LU, Yeo L, Tan B, Gopinathan A, Arenillas-Lara JF, Navia P, Raz E, Shapiro M, Arnberg F, Zeleňák K, Martínez-Galdámez M, Alexandrou M, Kastrup A, Papanagiotou P, Kemmling A, Dorn F, Psychogios M, Andersson T, Chapot R, Fiehler J, and Hanning U

Subjects
Male, Humans, Aged, Retrospective Studies, Treatment Outcome, Thrombectomy methods, Stroke diagnostic imaging, Stroke drug therapy, Stroke surgery, Brain Ischemia etiology, Infarction, Anterior Cerebral Artery etiology
Abstract

Background Evidence supporting a potential benefit of thrombectomy for distal medium vessel occlusions (DMVOs) of the anterior cerebral artery (ACA) is, to the knowledge of the authors, unknown. Purpose To compare the clinical and safety outcomes between mechanical thrombectomy (MT) and best medical treatment (BMT) with or without intravenous thrombolysis for primary isolated ACA DMVOs. Materials and Methods Treatment for Primary Medium Vessel Occlusion Stroke, or TOPMOST, is an international, retrospective, multicenter, observational registry of patients treated for DMVO in daily practice. Patients treated with thrombectomy or BMT alone for primary ACA DMVO distal to the A1 segment between January 2013 and October 2021 were analyzed and compared by one-to-one propensity score matching (PSM). Early outcome was measured by the median improvement of National Institutes of Health Stroke Scale (NIHSS) scores at 24 hours. Favorable functional outcome was defined as modified Rankin scale scores of 0-2 at 90 days. Safety was assessed by the occurrence of symptomatic intracerebral hemorrhage and mortality. Results Of 154 patients (median age, 77 years; quartile 1 [Q1] to quartile 3 [Q3], 66-84 years; 80 men; 94 patients with MT; 60 patients with BMT) who met the inclusion criteria, 110 patients (median age, 76 years; Q1-Q3, 67-83 years; 50 men; 55 patients with MT; 55 patients with BMT) were matched. DMVOs were in A2 (82 patients; 53%), A3 (69 patients; 45%), and A3 (three patients; 2%). After PSM, the median 24-hour NIHSS point decrease was -2 (Q1-Q3, -4 to 0) in the thrombectomy and -1 (Q1-Q3, -4 to 1.25) in the BMT cohort ( P = .52). Favorable functional outcome (MT vs BMT, 18 of 37 [49%] vs 19 of 39 [49%], respectively; P = .99) and mortality (MT vs BMT, eight of 37 [22%] vs 12 of 39 [31%], respectively; P = .36) were similar in both groups. Symptomatic intracranial hemorrhage occurred in three (2%) of 154 patients. Conclusion Thrombectomy appears to be a safe and technically feasible treatment option for primary isolated anterior cerebral artery occlusions in the A2 and A3 segment with clinical outcomes similar to best medical treatment with and without intravenous thrombolysis. © RSNA, 2023 Supplemental material is available for this article. See also the editorial by Zhu and Wang in this issue.

Published
2023
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32. Aspiration Versus Stent Retriever Thrombectomy for Distal, Medium Vessel Occlusion Stroke in the Posterior Circulation: A Subanalysis of the TOPMOST Study.

Author

Meyer L, Stracke P, Wallocha M, Broocks G, Sporns P, Piechowiak EI, Kaesmacher J, Maegerlein C, Hernandez Petzsche MR, Dorn F, Zimmermann H, Naziri W, Abdullayev N, Kabbasch C, Behme D, Jamous A, Maus V, Fischer S, Möhlenbruch M, Weyland CS, Langner S, Meila D, Miszczuk M, Siebert E, Lowens S, Krause LU, Yeo L, Tan B, Gopinathan A, Gory B, Galván-Fernández J, Schüller M, Navia P, Raz E, Shapiro M, Arnberg F, Zeleňák K, Martínez-Galdámez M, Kastrup A, Papanagiotou P, Kemmling A, Psychogios M, Andersson T, Chapot R, Fiehler J, and Hanning U

Subjects
Aged, Female, Humans, Intracranial Hemorrhages etiology, Male, Retrospective Studies, Stents adverse effects, Thrombectomy adverse effects, Treatment Outcome, Arterial Occlusive Diseases, Brain Ischemia therapy, Endovascular Procedures adverse effects, Ischemic Stroke, Stroke diagnostic imaging, Stroke etiology, Stroke surgery
Abstract

Background: The optimal endovascular strategy for reperfusing distal medium-vessel occlusions (DMVO) remains unknown. This study evaluates angiographic and clinical outcomes of thrombectomy strategies in DMVO stroke of the posterior circulation., Methods: TOPMOST (Treatment for Primary Medium Vessel Occlusion Stroke) is an international, retrospective, multicenter, observational registry of patients treated for DMVO between January 2014 and June 2020. This study analyzed endovascularly treated isolated primary DMVO of the posterior cerebral artery in the P2 and P3 segment. Technical feasibility was evaluated with the first-pass effect defined as a modified Thrombolysis in Cerebral Infarction Scale score of 3. Rates of early neurological improvement and functional modified Rankin Scale scores at 90 days were compared. Safety was assessed by the occurrence of symptomatic intracranial hemorrhage and intervention-related serious adverse events., Results: A total of 141 patients met the inclusion criteria and were treated endovascularly for primary isolated DMVO in the P2 (84.4%, 119) or P3 segment (15.6%, 22) of the posterior cerebral artery. The median age was 75 (IQR, 62-81), and 45.4% (64) were female. The initial reperfusion strategy was aspiration only in 29% (41) and stent retriever in 71% (100), both achieving similar first-pass effect rates of 53.7% (22) and 44% (44; P =0.297), respectively. There were no significant differences in early neurological improvement (aspiration: 64.7% versus stent retriever: 52.2%; P =0.933) and modified Rankin Scale rates (modified Rankin Scale score 0-1, aspiration: 60.5% versus stent retriever 68.6%; P =0.4). In multivariable logistic regression analysis, the time from groin puncture to recanalization was associated with the first-pass effect (adjusted odds ratio, 0.97 [95% CI, 0.95-0.99]; P <0.001) that in turn was associated with early neurological improvement (aOR, 3.27 [95% CI, 1.16-9.21]; P <0.025). Symptomatic intracranial hemorrhage occurred in 2.8% (4) of all cases., Conclusions: Both first-pass aspiration and stent retriever thrombectomy for primary isolated posterior circulation DMVO seem to be safe and technically feasible leading to similar favorable rates of angiographic and clinical outcome.

Published
2022
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33. Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke: The TOPMOST Study.

Author

Meyer L, Stracke CP, Jungi N, Wallocha M, Broocks G, Sporns PB, Maegerlein C, Dorn F, Zimmermann H, Naziri W, Abdullayev N, Kabbasch C, Behme D, Jamous A, Maus V, Fischer S, Möhlenbruch M, Weyland CS, Langner S, Meila D, Miszczuk M, Siebert E, Lowens S, Krause LU, Yeo LLL, Tan BY, Anil G, Gory B, Galván J, Arteaga MS, Navia P, Raz E, Shapiro M, Arnberg F, Zelenák K, Martinez-Galdamez M, Fischer U, Kastrup A, Roth C, Papanagiotou P, Kemmling A, Gralla J, Psychogios MN, Andersson T, Chapot R, Fiehler J, Kaesmacher J, and Hanning U

Subjects
Administration, Intravenous, Aged, Aged, 80 and over, Brain Ischemia diagnostic imaging, Brain Ischemia epidemiology, Case-Control Studies, Cerebrovascular Disorders diagnostic imaging, Cerebrovascular Disorders epidemiology, Cerebrovascular Disorders therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Stroke diagnostic imaging, Stroke epidemiology, Brain Ischemia therapy, Posterior Cerebral Artery diagnostic imaging, Stroke therapy, Thrombectomy methods, Thrombolytic Therapy methods
Abstract

Importance: Clinical evidence of the potential treatment benefit of mechanical thrombectomy for posterior circulation distal, medium vessel occlusion (DMVO) is sparse., Objective: To investigate the frequency as well as the clinical and safety outcomes of mechanical thrombectomy for isolated posterior circulation DMVO stroke and to compare them with the outcomes of standard medical treatment with or without intravenous thrombolysis (IVT) in daily clinical practice., Design, Setting, and Participants: This multicenter case-control study analyzed patients who were treated for primary distal occlusion of the posterior cerebral artery (PCA) of the P2 or P3 segment. These patients received mechanical thrombectomy or standard medical treatment (with or without IVT) at 1 of 23 comprehensive stroke centers in Europe, the United States, and Asia between January 1, 2010, and June 30, 2020. All patients who met the inclusion criteria were matched using 1:1 propensity score matching., Interventions: Mechanical thrombectomy or standard medical treatment with or without IVT., Main Outcomes and Measures: Clinical end point was the improvement of National Institutes of Health Stroke Scale (NIHSS) scores at discharge from baseline. Safety end point was the occurrence of symptomatic intracranial hemorrhage and hemorrhagic complications were classified based on the Second European-Australasian Acute Stroke Study (ECASSII). Functional outcome was evaluated with the modified Rankin Scale (mRS) score at 90-day follow-up., Results: Of 243 patients from all participating centers who met the inclusion criteria, 184 patients were matched. Among these patients, the median (interquartile range [IQR]) age was 74 (62-81) years and 95 (51.6%) were female individuals. Posterior circulation DMVOs were located in the P2 segment of the PCA in 149 patients (81.0%) and in the P3 segment in 35 patients (19.0%). At discharge, the mean NIHSS score decrease was -2.4 points (95% CI, -3.2 to -1.6) in the standard medical treatment cohort and -3.9 points (95% CI, -5.4 to -2.5) in the mechanical thrombectomy cohort, with a mean difference of -1.5 points (95% CI, 3.2 to -0.8; P = .06). Significant treatment effects of mechanical thrombectomy were observed in the subgroup of patients who had higher NIHSS scores on admission of 10 points or higher (mean difference, -5.6; 95% CI, -10.9 to -0.2; P = .04) and in the subgroup of patients without IVT (mean difference, -3.0; 95% CI, -5.0 to -0.9; P = .005). Symptomatic intracranial hemorrhage occurred in 4 of 92 patients (4.3%) in each treatment cohort., Conclusions and Relevance: This study suggested that, although rarely performed at comprehensive stroke centers, mechanical thrombectomy for posterior circulation DMVO is a safe, and technically feasible treatment option for occlusions of the P2 or P3 segment of the PCA compared with standard medical treatment with or without IVT.

Published
2021
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