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3. Association of Pharmacologic Treatment of Urgency Urinary Incontinence With Sleep Quality and Daytime Sleepiness

Author

Warsi, Qurratul A, Huang, Alison J, Hess, Rachel, Arya, Lily A, Richter, Holly E, Bradley, Catherine S, Rogers, Rebecca G, Myers, Deborah L, Johnson, Karen C, Winkelman, William D, Gregory, W Thomas, Kraus, Stephen R, Schembri, Michael, Brown, Jeanette S, Stone, Katie L, and Subak, Leslee L

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Research, Urologic Diseases, Behavioral and Social Science, Sleep Research, Aging, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Benzhydryl Compounds, Double-Blind Method, Female, Humans, Middle Aged, Muscarinic Antagonists, Self Report, Sleep, Treatment Outcome, Urinary Bladder, Overactive, Urinary Incontinence, Urge, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

ObjectiveTo evaluate the association between pharmacologic therapy for urgency urinary incontinence (UUI) and sleep quality.MethodsWe conducted a planned secondary data analysis of sleep outcomes in a previously conducted multicenter, double-blind, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence among community-dwelling women self-diagnosed using the 3-Incontinence Questions questionnaire. Participants (N=645) were assigned randomly to 4-8 mg antimuscarinic therapy daily or placebo. At baseline and 12 weeks, participants completed a validated voiding diary to evaluate incontinence and voiding symptoms, the Pittsburgh Sleep Quality Index to evaluate sleep quality, and the Epworth Sleepiness Scale to evaluate daytime sleepiness.ResultsMean (SD) age was 56 (±14) years, 68% were white, and 57% had poor sleep quality (Pittsburgh Sleep Quality Index score greater than 5). Mean frequency of any urinary incontinence and UUI was 4.6 and 3.9 episodes/d, respectively. After 12 weeks, women randomized to the antimuscarinic group reported greater decrease compared with the placebo group in UUI frequency (0.9 episodes/d; P

Published
2018

7. Urinary incontinence management costs are reduced following Burch or sling surgery for stress incontinence

Author

Subak, Leslee L, Goode, Patricia S, Brubaker, Linda, Kusek, John W, Schembri, Michael, Lukacz, Emily S, Kraus, Stephen R, Chai, Toby C, Norton, Peggy, Tennstedt, Sharon L, and Network, Urinary Incontinence Treatment

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Urologic Diseases, Clinical Research, Renal and urogenital, Diapers, Adult, Female, Humans, Incontinence Pads, Laundering, Menstrual Hygiene Products, Middle Aged, Multivariate Analysis, Postoperative Period, Suburethral Slings, Surveys and Questionnaires, United States, Urinary Incontinence, Stress, Urologic Surgical Procedures, costs, cost analysis, urinary incontinence, urinary incontinence costs, Urinary Incontinence Treatment Network, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

ObjectiveThe objective of the study was to estimate the effect of Burch and fascial sling surgery on out-of-pocket urinary incontinence (UI) management costs at 24 months postoperatively and identify predictors of change in cost among women enrolled in a randomized trial comparing these procedures.Study designResources used for UI management (supplies, laundry, dry cleaning) were self-reported by 491 women at baseline and 24 months after surgery, and total out-of-pocket costs for UI management (in 2012 US dollars) were estimated. Data from the 2 surgical groups were combined to examine the change in cost for UI management over 24 months. Univariate and bivariate changes in cost were analyzed using the Wilcoxon signed rank test. Predictors of change in cost were examined using multivariate mixed models.ResultsAt baseline mean (±SD) age of participants was 53 ± 10 years, and the frequency of weekly UI episodes was 23 ± 21. Weekly UI episodes decreased by 86% at 24 months (P < .001). The mean weekly cost was $16.60 ± $27.00 (median $9.39) at baseline and $4.57 ± $15.00 (median $0.10) at 24 months (P < .001), a decrease of 72%. In multivariate analyses, cost decreased by $3.38 ± $0.77 per week for each decrease of 1 UI episode per day (P < .001) and was strongly associated with greater improvement in Urogenital Distress Inventory and Incontinence Impact Questionnaire scores (P < .001) and decreased 24-hour pad weight (P < .02).ConclusionFollowing Burch or fascial sling surgery, the UI management cost at 24 months decreased by 72% ($625 per woman per year) and was strongly associated with decreasing UI frequency. Reduced out-of-pocket expenses may be a benefit of these established urinary incontinence procedures.

Published
2014

8. Long-term efficacy and safety of questionnaire-based initiation of urgency urinary incontinence treatment

Author

Hess, Rachel, Huang, Alison J, Richter, Holly E, Ghetti, Chiara C, Sung, Vivian W, Barrett-Connor, Elizabeth, Gregory, W Thomas, Pinkerton, JoAnn V, Bradley, Catherine S, Kraus, Stephen R, Rogers, Rebecca G, Subak, Leslee L, Johnson, Karen C, Arya, Lily A, Schembri, Michael, and Brown, Jeanette S

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Urologic Diseases, Clinical Research, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Aged, 80 and over, Benzhydryl Compounds, Female, Humans, Middle Aged, Muscarinic Antagonists, Patient Satisfaction, Surveys and Questionnaires, Urinary Incontinence, primary care, treatment, urgency urinary incontinence, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

ObjectiveThe objective of the study was to determine the longer-term efficacy and safety of initiating treatment for urgency-predominant urinary incontinence (UUI) in women diagnosed using a simple questionnaire rather than an extensive evaluation.Study designWomen completing a 12 week randomized controlled trial of fesoterodine therapy for UUI diagnosed by questionnaire were invited to participate in a 9 month, open-label continuation study. UUI and voiding episodes were collected using voiding diaries. Participant satisfaction was measured by questionnaire. Safety was assessed by the measurement of postvoid residual volume and adverse event monitoring; if necessary, women underwent a specialist evaluation. The longitudinal changes in UUI and voiding episodes were evaluated using linear mixed models adjusting for baseline.ResultsOf the 567 women completing the randomized trial, 498 (87.8%) took at least 1 dose of medication during this open-label study. Compared with the baseline visit in the randomized trial, fesoterodine was associated with a reduction in total incontinence episodes per day and urgency incontinence episodes per day at the end of the open-label study (adjusted mean [SE], 4.6 [0.12] to 1.2 [0.13] and 3.9 [0.11] to 0.9 [0.11], respectively, P < .0001 for both). Most women were satisfied with treatment (89%, 92%, and 93% at 3, 6, and 9 months, respectively). Twenty-six women experienced 28 serious adverse events, 1 of which was considered possibly treatment related. Twenty-two women had a specialist evaluation: 5 women's incontinence was misclassified by the 3 Incontinence Questions; none experienced harm because of misclassification.ConclusionUsing a simple validated questionnaire to diagnose and initiate treatment for UUI in community-dwelling women is safe and effective, allowing timely treatment by primary care practitioners.

Published
2013

9. Attitudes and the Prediction of Behavior: A Meta-analysis.

Author

Kraus, Stephen J.

Abstract

The relationship between attitudes and behavior has been a topic of considerable debate. Accordingly, this paper reports a meta-analysis of 83 attitude-behavior studies. The analysis suggests that attitudes significantly predict future behavior (combined p<<.000000000001); the average attitude-behavior correlation (ABC) is r=.38. Methodologically, ABCs are higher for studies using: (1) self-report measures of behavior; (2) primarily non-students as subjects; or (3) attitude and behavior measures of corresponding levels of specificity. Substantively, ABCs tend to be higher when the attitude is formed by direct experience, the attitude is held with certainty, the subject is a low self-monitor, or the situation increases self-focused attention. The limitations and future directions of attitude-behavior research are discussed. (Author/TE)

Published
1990

10. Process for development of multicenter urodynamic studies

Author

Nager, Charles W, Albo, Michael E, Fitzgerald, Mary P, McDermott, Susan M, Kraus, Stephen, Richter, Holly E, and Zimmern, Philippe

Abstract

OBJECTIVES To describe our experiences with a continuous quality improvement process for the standardization of multicenter urodynamic studies (UDSs) in a multi-institutional network. Multicenter UDSs can have considerable variations in testing procedures, training, equipment, and reviewer biases. METHODS A quality control process was developed that included protocol development, certification of modynamic testers, central review to assess compliance with protocol and quality, protocol modifications, standardization of equipment and signal configuration, development of an electronic signal repository, and the development of UDS Interpretation Guidelines. RESULTS We describe our experience and process in the development and implementation of a standardized UDS protocol in a multicenter surgical trial for stress urinary incontinence. The process included our protocol development, quality control measures, standardization processes, electronic signal repository, and the need for UDS Interpretation Guidelines. A urodynamic testing procedures protocol was implemented successfully by 20 urodynamic testers at nine continence treatment centers. The protocol provides explicit and detailed guidelines for equipment, calibration, patient position, specific annotations, lay language bladder sensation parameters, visual leak point pressure techniques, modifications for prolapse, and data recording. A UDS Interpretation Guidelines document provides specific suggestions for validity and plausibility determination, expected ranges of urodynamic variables, and reasonable agreement of measuring systems. Both documents are available to urodynamic investigators on the Urinary Incontinence Treatment Network website (http://WWW.Llitn.net/resourcesforphysicians.htm). CONCLUSIONS Multicenter UDSs require a continuous quality improvement process and the development of UDS testing procedures and interpretation guidelines. (c) 2007 Elsevier Inc.

Published
2007

21. sj-pdf-1-imr-10.1177_03000605221098176 - Supplemental material for Evaluating and understanding combination therapy decision drivers for the treatment of overactive bladder in the United States

Author

Kraus, Stephen R., Li, Junlong, Kristy, Rita M., Lockefeer, Amy, Yang, Hongbo, Zhou, Mo, and Walker, David R.

Subjects
111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-imr-10.1177_03000605221098176 for Evaluating and understanding combination therapy decision drivers for the treatment of overactive bladder in the United States by Stephen R. Kraus, Junlong Li, Rita M. Kristy, Amy Lockefeer, Hongbo Yang, Mo Zhou and David R. Walker in Journal of International Medical Research

Published
2022
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29. Syphilis

Author

Lossick, Joseph G., Kraus, Stephen J., Evans, Alfred S., editor, and Brachman, Philip S., editor

Published
1991
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30. The AUA/SUFU Guideline on Adult Neurogenic Lower Urinary Tract Dysfunction: Treatment and Follow-up

Author

Ginsberg, David A., primary, Boone, Timothy B., additional, Cameron, Anne P., additional, Gousse, Angelo, additional, Kaufman, Melissa R., additional, Keays, Erick, additional, Kennelly, Michael J., additional, Lemack, Gary E., additional, Rovner, Eric S., additional, Souter, Lesley H., additional, Yang, Claire C., additional, and Kraus, Stephen R., additional

Published
2021
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31. The AUA/SUFU Guideline on Adult Neurogenic Lower Urinary Tract Dysfunction: Diagnosis and Evaluation

Author

Ginsberg, David A., primary, Boone, Timothy B., additional, Cameron, Anne P., additional, Gousse, Angelo, additional, Kaufman, Melissa R., additional, Keays, Erick, additional, Kennelly, Michael J., additional, Lemack, Gary E., additional, Rovner, Eric S., additional, Souter, Lesley H., additional, Yang, Claire C., additional, and Kraus, Stephen R., additional

Published
2021
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43. Retropubic versus transobturator midurethral slings for stress incontinence

Author

Richter, Holly E., Albo, Michael E., Zyczynski, Halina M., Kenton, Kimberly, Norton, Peggy A., Sirls, Larry T., Kraus, Stephen R., Chai, Toby C., Lemack, Gary E., Dandreo, Kimberly J., Varner, R. Edward, Menefee, Shawn, Ghetti, Chiara, Brubaker, Linda, Nygaard, Ingrid, Khandwala, Salil, Rozanski, Thomas A., Johnson, Harry, Schaffer, Joseph, Stoddard, Anne M., Holley, Robert L., Nager, Charles W., Moalli, Pamela, Mueller, Elizabeth, Arisco, Amy M., Corton, Marlene, Tennstedt, Sharon, Chang, T. Debuene, Gormley, E. Ann, and Litman, Heather J.

Subjects
Urinary stress incontinence -- Care and treatment, Prostatectomy -- Comparative analysis, Prostatectomy -- Health aspects
Abstract

The study aims to evaluate and compare the efficacy of retropubic versus transobturator midurethral slings as a form of treatment for stress incontinence. The results indicate that both methods had similar effectiveness; however, the need to discuss the complications associated with both procedures with patients considering treatment is highlighted.

Published
2010

50. Burch colposuspension versus fascial sling to reduce urinary stress incontinence

Author

Albo, Michael E., Richter, Holly E., Brubaker, Linda, Norton, Peggy, Kraus, Stephen R., Zimmern, Philippe E., Chai, Toby C., Zyczynski, Halina, Diokno, Ananias C., Tennstedt, Sharon, Nager, Charles, Lloyd, Keith L., FitzGerald, MaryPat, Lemack, Gary E., Johnson, Harry W., Leng Wendy, Mallett, Veronica, Stoddard, Anne M., Menefee, Shawn, Varner, Edward R., Kenton, Kimberly, Moalli, Pam, Sirls, Larry, Dandreo, Kimberly J., Kusek, John W., Nyberg, Leroy M., and Steers, William

Subjects
Urinary stress incontinence -- Care and treatment, Urinary organs -- Surgery, Urinary organs -- Research, Urinary organs -- Usage
Abstract

Trials were performed to compare the efficacy and safety of the pubovaginal sling by using autologous rectus fascia and Burch colposuspension procedures 24 months after surgery. The autologous fascial sling showed a higher rate of successful treatment of stress incontinence but also greater morbidity than the Burch colposuspension.

Published
2007

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