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160 results on '"Krasnova, Irina N."'

7. Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice

Author

Universidad de Sevilla. Departamento de Fisiología, National Institutes of Health. United States, Mejías Estévez, Rebeca María, Rodríguez Gotor, Juan J., Niwa, Minae, Krasnova, Irina N., Adamczyk, Abby, Han, Mei, Wang, Tao, Universidad de Sevilla. Departamento de Fisiología, National Institutes of Health. United States, Mejías Estévez, Rebeca María, Rodríguez Gotor, Juan J., Niwa, Minae, Krasnova, Irina N., Adamczyk, Abby, Han, Mei, and Wang, Tao

Abstract

Novelty-seeking behaviors and impulsivity are personality traits associated with several psychiatric illnesses including attention deficits hyperactivity disorders. The underlying neural mechanisms remain poorly understood. We produced and characterized a line of knockout mice for zdhhc15, which encodes a neural palmitoyltransferase. Genetic defects of zdhhc15 were implicated in intellectual disability and behavioral anomalies in humans. Zdhhc15-KO mice showed normal spatial learning and working memory but exhibited a significant increase in novelty-induced locomotion in open field. Striatal dopamine content was reduced but extracellular dopamine levels were increased during the habituation phase to a novel environment. Administration of amphetamine and methylphenidate resulted in a significant increase in locomotion and extracellular dopamine levels in the ventral striatum of mutant mice compared to controls. Number and projections of dopaminergic neurons in the nigrostriatal and mesolimbic pathways were normal. No significant change in the basal palmitoylation of known ZDHHC15 substrates including DAT was detected in striatum of zdhhc15 KO mice using an acyl-biotin exchange assay. These results support that a transient, reversible, and novelty-induced elevation of extracellular dopamine in ventral striatum contributes to novelty-seeking behaviors in rodents and implicate ZDHHC15-mediated palmitoylation as a novel regulatory mechanism of dopamine in the striatum.

Published
2021

24. Compulsive drug use is associated with imbalance of orbitofrontal- and prelimbic-striatal circuits in punishment-resistant individuals.

Author

Yuzheng Hu, Salmeron, Betty Jo, Krasnova, Irina N., Hong Gu, Hanbing Lu, Antonello Bonci, Jean L. Cadet, Elliot A. Stein, and Yihong Yang

Subjects
SUBSTANCE abuse, PATHOLOGICAL psychology, METHAMPHETAMINE abuse, LABORATORY rats, BRAIN stimulation
Abstract

Substance use disorders (SUDs) impose severe negative impacts upon individuals, their families, and society. Clinical studies demonstrate that some chronic stimulant users are able to curtail their drug use when faced with adverse consequences while others continue to compulsively use drugs. The mechanisms underlying this dichotomy are poorly understood, which hampers the development of effective individualized treatments of a disorder that currently has no Food and Drug Administration-approved pharmacological treatments. In the present study, using a rat model of methamphetamine self-administration (SA) in the presence of concomitant foot shocks, thought to parallel compulsive drug taking by humans, we found that SA behavior correlated with alterations in the balance between an increased orbitofrontal cortex-dorsomedial striatal "go" circuit and a decreased prelimbic cortex-ventrolateral striatal "stop" circuit. Critically, this correlation was seen only in rats who continued to self-administer at a relatively high rate despite receiving foot shocks of increasing intensity. While the stop circuit functional connectivity became negative after repeated SA in all rats, "shockresistant" rats showed strengthening of this negative connectivity after shock exposure. In contrast, "shock-sensitive" rats showed a return toward their baseline levels after shock exposure. These results may help guide novel noninvasive brain stimulation therapies aimed at restoring the physiological balance between stop and go circuits in SUDs. [ABSTRACT FROM AUTHOR]

Published
2019
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25. Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii

Author

Kannan, Geetha, primary, Crawford, Joshua A., additional, Yang, ChunXia, additional, Gressitt, Kristin L., additional, Ihenatu, Chinezimuzo, additional, Krasnova, Irina N., additional, Cadet, Jean Lud, additional, Yolken, Robert H., additional, Severance, Emily G., additional, and Pletnikov, Mikhail V., additional

Published
2016
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28. Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia-related endophenotypes

Author

Brown, P. Leon, Shepard, Paul D., Elmer, Greg I., Stockman, Sara, McFarland, Rebecca, Mayo, Cheryl L., Cadet, Jean Lud, Krasnova, Irina N., Greenwald, Martin, Schoonover, Carrie, and Vogel, Michael W.

Subjects
Male, Serotonin, Neuronal Plasticity, Endophenotypes, Dopamine, Neurogenesis, Cytarabine, Hippocampus, Article, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Norepinephrine, Schizophrenia, 3,4-Dihydroxyphenylacetic Acid, Animals, skin and connective tissue diseases, Maze Learning
Abstract

Adult rats exposed to the DNA-methylating agent methylazoxymethanol on embryonic day 17 show a pattern of neurobiological deficits that model some of the neuropathological and behavioral changes observed in schizophrenia. Although it is generally assumed that these changes reflect targeted disruption of embryonic neurogenesis, it is unknown whether these effects generalise to other antimitotic agents administered at different stages of development. In the present study, neurochemical, behavioral and electrophysiological techniques were used to determine whether exposure to the antimitotic agent Ara-C later in development recapitulates some of the changes observed in methylazoxymethanol (MAM)-treated animals and in patients with schizophrenia. Male rats exposed to Ara-C (30 mg/kg/day) at embryonic days 19.5 and 20.5 show reduced cell numbers and heterotopias in hippocampal CA1 and CA2/3 regions, respectively, as well as cell loss in the superficial layers of the pre- and infralimbic cortex. Birth date labeling with bromodeoxyuridine reveals that the cytoarchitectural changes in CA2/3 are a consequence rather that a direct result of disrupted cortical neurogenesis. Ara-C-treated rats possess elevated levels of cortical dopamine and DOPAC (3,4-didyhydroxypheylacetic acid) but no change in norepinephrine or serotonin. Ara-C-treated rats are impaired in their ability to learn the Morris water maze task and showed diminished synaptic plasticity in the hippocampocortical pathway. These data indicate that disruption of neurogenesis at embryonic days 19.5 and 20.5 constitutes a useful model for the comparative study of deficits observed in other gestational models and their relationship to cognitive changes observed in schizophrenia.

Published
2012

34. CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat

Author

Krasnova, Irina N., primary, Chiflikyan, Margarit, additional, Justinova, Zuzana, additional, McCoy, Michael T., additional, Ladenheim, Bruce, additional, Jayanthi, Subramaniam, additional, Quintero, Cynthia, additional, Brannock, Christie, additional, Barnes, Chanel, additional, Adair, Jordan E., additional, Lehrmann, Elin, additional, Kobeissy, Firas H., additional, Gold, Mark S., additional, Becker, Kevin G., additional, Goldberg, Steven R., additional, and Cadet, Jean Lud, additional

Published
2013
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40. Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology

Author

Abazyan, Bagrat, primary, Nomura, Jun, additional, Kannan, Geetha, additional, Ishizuka, Koko, additional, Tamashiro, Kellie L., additional, Nucifora, Frederick, additional, Pogorelov, Vladimir, additional, Ladenheim, Bruce, additional, Yang, Chunxia, additional, Krasnova, Irina N., additional, Cadet, Jean Lud, additional, Pardo, Carlos, additional, Mori, Susumu, additional, Kamiya, Atsushi, additional, Vogel, Michael W., additional, Sawa, Akira, additional, Ross, Christopher A., additional, and Pletnikov, Mikhail V., additional

Published
2010
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